TW201208648A - Multi-point optical measurement device and equipment for measuring a microcirculation on a body surface - Google Patents

Multi-point optical measurement device and equipment for measuring a microcirculation on a body surface Download PDF

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TW201208648A
TW201208648A TW99128126A TW99128126A TW201208648A TW 201208648 A TW201208648 A TW 201208648A TW 99128126 A TW99128126 A TW 99128126A TW 99128126 A TW99128126 A TW 99128126A TW 201208648 A TW201208648 A TW 201208648A
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Taiwan
Prior art keywords
signal
light
optical
switch
electrically connected
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TW99128126A
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Chinese (zh)
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Tain-Song Chen
Yi-Chun Du
Ying-Jr Lin
Kai-Jie Yang
Yu-Jeng Li
jian-xing Wu
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Tain-Song Chen
Yi-Chun Du
Ying-Jr Lin
Kai-Jie Yang
Yu-Jeng Li
jian-xing Wu
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Application filed by Tain-Song Chen, Yi-Chun Du, Ying-Jr Lin, Kai-Jie Yang, Yu-Jeng Li, jian-xing Wu filed Critical Tain-Song Chen
Priority to TW99128126A priority Critical patent/TW201208648A/en
Publication of TW201208648A publication Critical patent/TW201208648A/en

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A multi-point optical measurement device and equipment for measuring a microcirculation on a body surface, it controls multiple light emitters in matrix to project infrared with different wavelength to a man body in sequence by setting a controller and a switch for fast switching, and to detect reflected light signals with multiple optical receivers through the special optical absorption property of different composition of the microvasculature on the peripheral skin of the man body, then the reflected light signals are demodulated to digital signals by a receive circuit, a signal switch, a filter amplifier circuit and the controller, then the signals are processed and analyzed by a processor. Besides, it is to show 2D testing images according to the relative space information by the property of matrix to observe the result of the measurement.

Description

201208648 六、發明說明: 【發明所屬之技術領域】 [0001] 本發明係有關於一種獲取體表微循環訊息之多點式 光電量測裝置及其設備,特別是指快速切換之陣列式排 列之光發射器與光接收器,進而依序發射與接收不同波 長之紅外光訊號,藉由分時的多點式檢測方式,進行人 體體表末梢區域微循環量測之裝置。 【先前技術·】 [0002] 近年國人罹患糖尿病的比例越來越高,相關的醫療 照護也日顯重要,尤其糖尿病屬慢性疾病,需長時間追 縱身體狀況,而其實當糖尿病患在周邊血管病變(peripheral vascular disease, PVD) 初期時 ,首先會出 現部分病徵反應到人體微循環系統,產生微循環功能的 異常。例如當病患末梢微循環狀況變差時,可能會造成 末梢組織的感染或敗血症狀,嚴重時甚至會造成截肢或 死亡。由於患者對於自身的末稍微循環狀況掌握並不容 易,且病患常伴隨交感與副交感神經失調,導致肢端末 稍感覺異常或遲鈍,更容易疏忽相關感染症狀。 為了使糖尿病患者能自我檢查或使醫護人員能快速 檢測患者之末稍微循環狀況,有藉由不同波長之紅外光 照射於人體,利用人體組織對紅外光吸收程度不一,分 析其反射之光訊號,再與正常人體之反射光訊號數值比 對後,判斷患者末梢組織微循環是否產生病變,甚至是 其病變程度,且此種方式係為非侵入式之檢測,對病患 不會造成不舒適的感覺;例如中華民國發明專利公告第 41 8081號「非侵入式血氧濃度計及其偵測方法以及波形 099128126 表單編號 A0101 第 4 頁/共 21 頁 0992049466-0 201208648 訊號之波峰波谷偵測方法」,其係以偵測探頭發出第一 波長光源及第二波長光源,再分別擷取該兩波長光源照 射受測者後,加以轉換成代表受測者金氧濃度所相對應 的第一電訊號與第二電訊號,並加以分析處理;再如中 華民國發明專利公告第1298630號「具可變結構的血液生 理信號感測裝置」,其具有一第一殼體,内含一光發射 元件以及一光接收元件,以及一第二殼體,電連接至該 第一殼體,並内含該血液生理信號感測裝置所需電路單 元的至少一部份,藉由血液對於光照的吸光度變化,而 感測生理訊號。 然而包括前述專利及過去的研究大多只針對單點的 患部量測,所以對末稍微循環評估相當主觀.,尤其這種 方式於不同量測位置有極大的差異,對於沒有量測經驗 的患者,需經過反覆訓練才得以測量正確數據。 【發明内容】 [0003] 〇 099128126 爰此,本發明主要目的在於提供一可對人體體表之 微循環進行紅外光多點式量測;進而利用多點檢測結果 形成二維造影之袭置及設備。: 根據本發明上述目的,因此本發明人基於不斷創新 研發之精神’而開發出一種獲取體表微循環訊息之多點 式光電量測裝置及其設備’包括·· 一光訊號收發單元’係設置複數光發射器及至少— 光接收器,該些光發射器係分別發射一紅外光,該任— 光接收器則接收該些紅外光之反射光;一切換開關,電 性連接該光訊號收發單元,藉以控制該些光發射器依序 發射紅外光;一接收電路,電性連接該光訊號收發單元 表單编號A0101 第5頁/共21頁 0992049466-0 201208648 ’將該任-光接收器接收之反射光光訊號轉換為電訊號 z訊號切換器,電性連接該接收電路,絲該電訊號 分類’-濾,波放大電%,電性連接該tfl號切換器係放 大該電訊號;-核心控制n,電性連接前述切換開關、 訊號切換器及遽波放大電路,該核心、控制器係控制該切 換開關之切換頻率’並控制該訊號切換器依據原反射光 光訊號之波長而分類該電訊號’亦將該渡波放大電路放 大之電訊號轉換為數位訊號;一處理單元,電性連接該 核心控制器,並將該數位訊號運算處理,產生—檢測晝 面;-顯示器,電性連接該處理單元,而輸出該檢測晝 面0201208648 VI. Description of the Invention: [Technical Field] [0001] The present invention relates to a multi-point photoelectric measuring device for acquiring body surface microcirculation information and an apparatus thereof, and more particularly to an array arrangement of fast switching The optical transmitter and the optical receiver sequentially transmit and receive infrared light signals of different wavelengths, and perform a micro-circulation measurement device for the surface area of the human body surface by means of a time-division multi-point detection method. [Previous technology] [0002] In recent years, the proportion of people suffering from diabetes is getting higher and higher, and related medical care is also becoming increasingly important. Especially diabetes is a chronic disease that requires long-term recovery of physical condition. In the early stage of the disease (peripheral vascular disease, PVD), some symptoms will first appear in the human microcirculation system, resulting in abnormal microcirculation function. For example, when the patient's peripheral microcirculatory condition deteriorates, it may cause infection or septic symptoms of the peripheral tissue, and even cause amputation or death in severe cases. It is not easy for the patient to master the slight circulation of the end, and the patient is often accompanied by sympathetic and parasympathetic disorders, resulting in a slight abnormality or dullness of the extremities, and it is easier to neglect the relevant infection symptoms. In order to enable the diabetic patients to self-examine or enable the medical staff to quickly detect the patient's slight circulation at the end, the infrared light of different wavelengths is irradiated to the human body, and the absorption of the infrared light by the human tissue is different, and the reflected optical signal is analyzed. After comparing with the reflected light signal value of the normal human body, it is judged whether the microcirculation of the peripheral tissue of the patient has a lesion or even a lesion degree, and the method is a non-invasive test, which does not cause discomfort to the patient. Feelings; for example, the Republic of China Invention Patent Bulletin No. 41 8081 "Non-invasive oximeter and its detection method and waveform 099128126 Form No. A0101 Page 4 of 21 0992049466-0 201208648 Signal peak wave valley detection method The detection probe emits a first wavelength light source and a second wavelength light source, and then respectively extracts the two wavelength light sources to illuminate the subject, and converts them into a first telecommunications corresponding to the subject's gold oxygen concentration. No. and the second electrical signal, and analyzed and processed; and, as in the Republic of China Invention Patent Notice No. 1298630, "with variable structure a blood physiological signal sensing device having a first housing containing a light emitting element and a light receiving element, and a second housing electrically connected to the first housing and containing the blood physiology At least a portion of the circuit components required by the signal sensing device sense physiological signals by changes in the absorbance of light to the light. However, most of the above-mentioned patents and past studies are only for single-point measurement of the affected part, so the slightly cyclical evaluation of the end is quite subjective. In particular, this method has great differences in different measurement positions. For patients without measurement experience, After repeated training, the correct data can be measured. SUMMARY OF THE INVENTION [0003] 0003099128126 Accordingly, the main object of the present invention is to provide a micro-circulation measurement of micro-circulation of a human body surface; device. According to the above object of the present invention, the inventors have developed a multi-point photoelectric measuring device for acquiring body surface microcirculation information based on the spirit of continuous innovation and research and the device 'including · an optical signal transceiver unit' a plurality of light emitters and at least one light receiver are disposed, wherein the light emitters respectively emit an infrared light, and the optical receiver receives the reflected light of the infrared light; and a switch is electrically connected to the optical signal The transceiver unit is configured to control the light emitters to sequentially emit infrared light; a receiving circuit electrically connected to the optical signal transceiver unit form number A0101, page 5 / total 21 pages 0992049466-0 201208648 'the light-light receiving The reflected optical signal received by the device is converted into a signal signal switch, electrically connected to the receiving circuit, and the electrical signal is classified as '-filter, wave amplified, and electrically connected to the tfl switch to amplify the electrical signal. ;-core control n, electrically connected to the aforementioned switch, signal switcher and chopper amplifier circuit, the core, the controller controls the switching frequency of the switch 'and controls the The number switcher classifies the electrical signal according to the wavelength of the original reflected light signal. The electrical signal amplified by the wave amplifying circuit is also converted into a digital signal; a processing unit is electrically connected to the core controller, and the digital signal is operated. Processing, generating - detecting the surface; - displaying, electrically connecting the processing unit, and outputting the detecting surface

其依據之技術原理係為利用光電技術,建立一套以 光體積變化描述波形(ph〇t〇piethesm〇graphy,ppG )為基礎的非侵人式光學量測***,在慢性病患中特 別是糖尿病患在大血管病變方面,會導致血管粥狀硬化 進展較一般人快速,容易造成血管狹窄與阻塞,而導致 血流減少與流速緩慢。以足部為例;,轉尿病足好發於兩 側下肢的脛動脈、腓動脈、足動脈灰小動脈,且以多段 式阻塞分佈,如果因大血管阻塞,造成末稍血管循環不 良而導致足部缺血,易引起足部潰瘍與組織壞死。透過 此系統可以監控病患血管容積變化,進而推估血管内血 液如·量與流速之改變,作為判斷末梢微循環之健康狀況 i藉此提供一簡單、輕便的可攜式系統’讓病患可以在 豕作自我的監控與照護,而藉由複數光發射器則可同時 對檢測處作多點檢測,降低檢測遺漏之機率。 099128126 進一步 表單編號A〇l〇i 該些光發射器呈至少一陣列之排列,而該 第6頁/共21頁 0992049466-0 201208648 光接收器之數量相同於光發射器陣列之數量,且該任_ 光接收器則設置於其所屬該些光發射器之陣列中央,同 時任一個光接收器與其所屬陣列之任一個光發射器距離 相同’藉此,該些光接收器可依據特定比例接收該些光 發射器所發出紅外光之反射光,而可對檢測處作較完整 而精確之檢測。 Ο 進一步,係設置一心電量測儀,其電性連接該處理 單元’而該處理單元依據該核心控制器產生之數位訊號 運算處理而產生光體積變化描述波形(PPG),該心電量 測儀則里測產生一心電圖訊.號.(ECG ):'v該處理單元進一 步由該光體積變化描述波形及心電圖訊號定義PTTp指標 、PTTf指標及Amp ratio指樨之特徵參數,作為辅助 PPG波形擷取量化參數之依據,並比對一儲存於該處理單 元之比對參數,而輸出該檢測畫面。本創作主要功效在 於: Ο [0004] 藉由快速切換陣列式排列之光發射器,可對人體末 梢組織之微循環進行多點式量測,量測較精準,可改善 因為單點式量測方式,而於檢測時產生遺漏之缺陷。 【實施方式】 綜合上述技術特徵,本發明主要功效將可於下述實 施例清楚呈現。 099128126 本發明裝置及設備之架構與使用請分別參閱第一圖 及第二圖所示’而本發明之裝置及設備係包括一光訊號 收發單元(1)、一核心控制器(2)、一切換開關(3) 、一接收電路(4)、一訊號切換器(5)、一濾波放大 電路(6) -處理單元⑺、一顯示器⑻及一心電量 表單編號A0101 第7頁/共21頁 0992049466-0 201208648 測儀(9 )。 該光訊號收發單元(1)係設置複數光發射器(11) 及至少一光接收器(1 2 ),該些光發射器(11 )係為可 發射波長為6 60nm至94 0nm之紅外光發光源,並呈至少― 陣列之排列,該任一光接收器(12)係為剛接收1C,用 於接收波長為500nm到700nm之反射光,並位於該些光發 射器(11 )之陣列中央,且該任一個光接收器(12 )與 其所屬陣列之任一個光發射器(11 )距離相同,使該些 光接收器(12)可依據特定比例接收該些光發射器(11 )所發出紅外光之反射光[請參閱第三、四圖],當該些 光發射器(11)與光接收器(12)之數量越多,並形成 越多組之陣列形式,可量測之範圍越大,所測得之數據 越精確。 使用上,係藉由該核心控制器(2)控制該切換開關 (3)以ΙΟΟΚΗζ的速度快速切換該些光發射器(11)朝 人體(A)依序發出波長約為66〇ni至940nm之紅外光, 099128126 而該核心控制器(2)係使用PIC321X675F512L單晶片 ’經由人體(A)末梢皮膚組貪内之微血管(b)不同成 分的特有光吸收特性,而反射不同波長之反射光,其原 理可概略說明如下,當一部份的紅外光光子照射到皮膚 、微血管(B)表層這些靜止的組織時,其反射光光子不 會產生都卜勒偏移效應,另一部份紅外光光子照射到微 循環中微血管(β)裡移動的紅血球(B1 )時,其散射的 紅外光頻率會因為紅血球(B1)粒子速度的影響,而產 生頻率偏移現象[請參閱第五圖],而反射光經由該任一 光接收器(12)接收後,經過該接收電路(4)將光訊號 0992049466-0 A0101 第8頁/共21頁 201208648 轉換為電訊號’由於人體(A)末梢組織不同成份之反射 光波長不盡相同,該核心控制器(2)再控制該訊號切換 器(5)依據反射光之波長而分類該電訊號,再經過該濾 波放大電路(6)適當放大該電訊號後’輪入至該核心控 制器(2),該核心控制器(2)則將該電訊號轉換為數 位訊號後,輸入至該處理單元(7),藉此求得光體積變 化描述波形[PPG],此外’再利用該心電量測儀(9)量 測產生一心電圖訊號[ECG],該處理單元(7)進一步由 PPG及ECG定義PTTp指標、PTT.fi曰仏及Amp ratio指標之 特徵參數,作為輔助PPG波形擷取量化參數之依據,該處 理單元(7)再將該些特徵參數經過處理比對正常人體( A)之比對參數[請參閱第六圖]’係為加入ECG訊號與 PPG進形同步比對之示意圖’圖中左侧係為正常人ECG波 形與左右兩腳趾PPG波形示意圖’右侧則為單邊下肢患 有PVD患者波形,其中定義ECG波形的R~peak到ρρς波 形的最高點之時間差為PTTp指標·’ ECG波雜的R_peak到 PPG波形的最低點之時間差為PTTf指標;PPG波形第一大 波振幅與第二小波振幅之比值為Amp ratio指標,藉由 定義這些特徵參數在人體肢端體表微循環評估例如足部 微循環,有良好的評估價值與意義。該顯示器(8)輸出 一比對後之檢測畫面,供使用者觀察檢測處是否正常或 產生感染病變’由於該些光發射器(11)依預先設定好 之順序將光源打入皮膚組織並接收反射的紅外光訊號, 藉此測量不同空間分部的組織循環狀況’而不需同時驅 動所有光發射器(11),也就是利用快速切換來達到區 域多通道量測之目的[請參閱第七圖’為各該光發射器( 099128126 表單編號A0101 第9頁/共21頁 0992049466-0 201208648 11 )依特定頻率快速切換之波形示意圖,圖中最上層顯 示該些光發射器(11 )發射紅外光之頻率,波峰顯示開 啟任一個該些光發器(11 )之狀態;圖中第二層、第三 層及第四層依序以下則代表各該光發射器(11),波峰 顯示其開啟發射紅外光之狀態,藉此快速切換該些光發 射器(11)依序發射紅外光],過程中會有些微接收時間 差異,但在高速切換下,仍可視為同步訊號擷取,藉此 反映測量患部當下的區域循環狀況。 而由於該些光發射器(11)呈陣列排列,可對人體 (A)末梢組織之微循環進行多點式量測,量測較精準, 可改善因為單點式量測方式,而於檢測時產生遺漏之缺 陷,同時,其反射光光訊號亦呈現陣列式,最終成像時 ,可呈現二維之檢測畫面,方便使用者觀察,而應用上 則可用於臨床上腫瘤的診斷、中醫脈像分析、腦部血量 及血氧分佈影像分析等廣泛應用,例如應用於糖尿病病 患之檢測時,由於糖尿病是屬於慢性疾病、,病患常需固 定來回醫院作診治,但有些不必要的檢查,卻常耗費病 患大量的時間,當病患利用此居家監控系統,將自己兩 腳足部的生理訊號,經系統分析並記錄下來,除了讓病 患能夠每天得到自己足部微循環的情況外,更可以將資 料經由網路傳給醫生做客觀的判斷,避免舟車勞頓,經 常來回醫院之痛苦,並可以達到及早發現及早治療的效 果。 【圖式簡單說明】 [0005] 第一圖係為本發明之裝置及設備之架構示意圖。 第二圖係為本發明之使用示意圖。 099128126 表單編號A0101 第10頁/共21頁 0992049466-0 201208648 第三圖係為本發明之光發射器及光接收器排列之示 意圖(一)。 第四圖係為本發明之光發射器及光接收器排列之示 意圖(二)。 第五圖係為紅外光光子照射紅血球粒子產生都卜勒 偏移之示意圖。 第六圖係為加入ECG訊號與PPG進形同步比對之示意 圖The technical principle is based on the use of optoelectronic technology to establish a non-invasive optical measurement system based on the description of the light volume change (ppG), especially in chronic patients. Diabetes in patients with macrovascular disease, can lead to vascular atherosclerosis progress faster than the average person, easily lead to vascular stenosis and obstruction, resulting in reduced blood flow and slow flow. Taking the foot as an example; the urethral disease occurs in the radial artery of the lower extremities of both sides, the radial artery, the arteriolar venous artery, and is blocked by a multi-segment. If the large blood vessel is blocked, the terminal vascular circulation is poor. Lead to ischemia of the foot, easy to cause foot ulcers and tissue necrosis. Through this system, the volume change of the patient's blood vessels can be monitored, and then the changes in blood volume and flow rate in the blood vessel can be estimated. As a judgment of the health status of the peripheral microcirculation, i can provide a simple and portable portable system. It can be used for self-monitoring and care, and with multiple light emitters, multiple detections can be performed at the same time to reduce the probability of detection omission. 099128126 Further Form No. A〇l〇i The light emitters are arranged in at least one array, and the number of the 6th/21st page 0992049466-0 201208648 light receivers is the same as the number of light emitter arrays, and Any optical receiver is disposed in the center of the array of optical transmitters to which it belongs, and any one of the optical receivers is at the same distance from any of the optical transmitters of the array to which it belongs. Thus, the optical receivers can receive according to a specific ratio. The light emitters emit reflected light from the infrared light, which enables a more complete and accurate detection of the detection. Ο Further, a cardiometer is electrically connected to the processing unit', and the processing unit generates a light volume change description waveform (PPG) according to the digital signal processing generated by the core controller, and the cardiac power measurement In the instrument, an ECG signal is generated. (ECG): 'v The processing unit further defines the PTTp index, the PTTf index, and the characteristic parameter of the Amp ratio index from the light volume change description waveform and the electrocardiogram signal as the auxiliary PPG waveform. The basis of the quantization parameter is captured, and the comparison picture stored in the processing unit is compared, and the detection picture is output. The main effects of this creation are: Ο [0004] By quickly switching the array of light emitters, multi-point measurement can be performed on the microcirculation of human body tissue, which is more accurate and can be improved because of single-point measurement. The way, while the detection produces a missing defect. [Embodiment] In synthesizing the above technical features, the main effects of the present invention will be clearly shown in the following embodiments. 099128126 The structure and use of the device and device of the present invention are respectively shown in the first figure and the second figure. The device and device of the present invention comprise an optical signal transceiver unit (1), a core controller (2), and a device. Switch (3), a receiving circuit (4), a signal switcher (5), a filter amplifier circuit (6) - a processing unit (7), a display (8) and a heart rate form number A0101 page 7 / 21 pages 0992049466 -0 201208648 Measurer (9). The optical signal transceiver unit (1) is provided with a plurality of light emitters (11) and at least one light receiver (11), and the light emitters (11) are infrared light having an emission wavelength of 6 60 nm to 94 0 nm. The light source is arranged in at least one of an array, and the optical receiver (12) is just received 1C for receiving reflected light having a wavelength of 500 nm to 700 nm, and is located at the center of the array of the light emitters (11). And any one of the light receivers (12) is at the same distance from any one of the light emitters (11) of the array, so that the light receivers (12) can receive the infrared emitted by the light emitters (11) according to a specific ratio. The reflected light of light [please refer to the third and fourth figures], the more the number of the light emitters (11) and the light receivers (12) are formed, and the more arrays are formed, the more the range that can be measured Large, the more accurate the measured data. In use, the core controller (2) controls the switch (3) to quickly switch the light emitters (11) at a speed of ΙΟΟΚΗζ to sequentially emit a wavelength of about 66〇ni to 940nm toward the human body (A). Infrared light, 099128126 and the core controller (2) uses the PIC321X675F512L single chip to reflect the reflected light of different wavelengths through the characteristic light absorption characteristics of different components of the microvessels (b) in the human skin (A) peripheral skin group. The principle can be roughly explained as follows. When a part of the infrared photons are irradiated to the stationary tissues of the skin and the surface of the microvessels (B), the reflected photons do not have a Doppler shift effect, and the other part of the infrared light. When photons are irradiated to the red blood cells (B1) moving in the microvessels (β) in the microcirculation, the frequency of the scattered infrared light will be frequency-shifted due to the influence of the particle velocity of the red blood cells (B1) [see the fifth figure]. After the reflected light is received by the optical receiver (12), the optical signal 0992049466-0 A0101 page 8/21 page 201208648 is converted into a telecommunication signal through the receiving circuit (4). The wavelength of the reflected light of different components is different, and the core controller (2) controls the signal switcher (5) to classify the electrical signal according to the wavelength of the reflected light, and then appropriately enlarges the signal through the filtering and amplifying circuit (6). After the electrical signal, the wheel controller is turned into the core controller (2). The core controller (2) converts the electrical signal into a digital signal and inputs it to the processing unit (7), thereby obtaining a description of the light volume change. Waveform [PPG], in addition, 'reuse the cardiometer (9) to generate an ECG signal [ECG], the processing unit (7) further defines PTTp index, PTT.fi曰仏 and Amp by PPG and ECG The characteristic parameter of the ratio indicator is used as the basis for the auxiliary PPG waveform to obtain the quantization parameter, and the processing unit (7) compares the characteristic parameters with the normal human body (A) to compare the parameters [see the sixth figure]. It is a schematic diagram of the synchronization of the ECG signal and the PPG. The left side of the figure is the normal human ECG waveform and the left and right toe PPG waveform diagram. The right side is the unilateral lower limb with PVD patient waveform, which defines the ECG waveform. R~peak to ρρς waveform The time difference between the highest point is the PTTp index · The time difference between the R_peak of the ECG wave and the lowest point of the PPG waveform is the PTTf index; the ratio of the first large wave amplitude to the second wavelet amplitude of the PPG waveform is the Amp ratio index, by defining these characteristic parameters In the human limbs surface microcirculation assessment, such as the foot microcirculation, has a good evaluation value and significance. The display (8) outputs a comparison detection screen for the user to observe whether the detection area is normal or produces an infected lesion' because the light emitters (11) drive the light source into the skin tissue and receive in a preset order. Reflected infrared light signals, thereby measuring the tissue circulation of different spatial segments' without driving all light emitters (11) at the same time, that is, using fast switching to achieve regional multi-channel measurement [see seventh Figure ' is a schematic diagram of the waveforms of each of the light emitters (099128126 Form No. A0101, page 9/21 pages 0992049466-0 201208648 11), which are rapidly switched according to a specific frequency. The uppermost layer of the figure shows that the light emitters (11) emit infrared light. The frequency of the light, the peak indicates the state of turning on any of the light emitters (11); the second layer, the third layer and the fourth layer in the figure sequentially represent each of the light emitters (11), and the peaks show Turn on the state of emitting infrared light, thereby quickly switching the light emitters (11) to sequentially emit infrared light], there will be some micro-reception time difference in the process, but under high-speed switching, it can still be regarded as the same The step signal is taken to reflect the current cycle condition of the affected part. Since the light emitters (11) are arranged in an array, multi-point measurement can be performed on the microcirculation of the human body (A), and the measurement is more accurate, which can improve the single-point measurement method and detect At the same time, the reflected light and light signals are also arrayed. When the final image is formed, a two-dimensional detection image can be presented for the user to observe, and the application can be used for clinical tumor diagnosis and Chinese medicine pulse image. Analysis, brain blood volume and blood oxygen distribution image analysis and other widely used, for example, when applied to the detection of diabetic patients, because diabetes is a chronic disease, patients often need to be fixed to and from the hospital for treatment, but some unnecessary examinations However, it often takes a lot of time for patients. When patients use this home monitoring system, they can systematically analyze and record the physiological signals of their feet and feet, in addition to allowing patients to get their own foot microcirculation every day. In addition, the data can be transmitted to the doctor through the Internet for objective judgment, avoiding the pain of the boat, often going back and forth to the hospital, and reaching early detection. The effect of treatment. BRIEF DESCRIPTION OF THE DRAWINGS [0005] The first figure is a schematic diagram of the structure of the device and device of the present invention. The second figure is a schematic diagram of the use of the present invention. 099128126 Form No. A0101 Page 10 of 21 0992049466-0 201208648 The third figure is an illustration (1) of the arrangement of the light emitter and the light receiver of the present invention. The fourth figure is the schematic (2) of the arrangement of the light emitter and the light receiver of the present invention. The fifth figure is a schematic diagram of the Doppler shift generated by infrared photon irradiation of red blood cell particles. The sixth picture is a schematic diagram of the synchronization comparison between the ECG signal and the PPG.

第七圖係為各該光發射器依特定頻率快速切換之波 形示意圖。 【主要元件符號說明】 [0006]The seventh figure is a schematic diagram of the waveform of each of the light emitters being quickly switched at a specific frequency. [Main component symbol description] [0006]

(1 ) 光訊號收發單元 ( 1 1 )光發射器 (1 2)光接收器 ( 2 ) 核心控制器 (3) 切換開關 ( 4 ) 接收電路 (5) 訊號切換器 ( 6 ) 濾波放大電路 (7) 處理單元 ( 8 ) 顯示器 (9) 心電量測儀 (A ) 人體 (B ) 微血管 (B1)紅血球 099128126 表單編號A0101 第11頁/共21頁 0992049466-0(1) Optical transceiver unit (1 1) Optical transmitter (1 2) Optical receiver (2) Core controller (3) Switch (4) Receiver circuit (5) Signal switcher (6) Filter amplifier circuit ( 7) Handling unit ( 8 ) Display (9) Heart rate meter (A ) Human body (B ) Micro blood vessel (B1) red blood cell 099128126 Form number A0101 Page 11 of 21 0992049466-0

Claims (1)

201208648 七、申請專利範圍: 1 . 一種獲取體表微循環訊息之多點式光電量測裝置,包括: -光訊號收發單元,係設置複㈣發射器及至少一光 接收器’該些光發射器係分別發射一紅外光,該任_光接 收器則接收該些紅外光之反射光; 一切換開關,電性連接該光訊號收發單元,藉以控制 該些光發射器依序發射紅外光; 接收電路%性連接該光訊號收發單元,將該任一 光接收器接收之反射光光訊號轉換备電訊號; 訊號切換器,電性連接該接收電路,並將該電訊號 分類; 一濾波放大電路,電性連接該訊鏡切換器,係放大該 電訊號; 一核心控制器’電性連接前述切換開關、訊號切換器 及濾波放大電路’該核心控制器係控制該切換開關之切換 頻率’並控制該訊號切換器依捸原反射光光訊號之波長而 分類该電訊號’亦將該濾波放#電路放大之電訊號轉換為 數位訊號。 2 ·如申請專利範圍第丨項所述之獲取體表微循環訊息之多點 式光電量測裝置’其中該些光發射器呈至少一陣列之排列 ’而該光接收器之數量相同於光發射器陣列之數量,且該 任一光接收器係設置於其所屬該些光發射器之陣列中央。 3 ·如申請專利範圍第2項所述之獲取體表微循環訊息之多點 式光電量測裝置,其中任一個光接收器與其所屬陣列之任 一個光發射器距離相同。 099128126 表單編號A0101 第丨2頁/共21頁 0992049466-0 201208648 4 . 一種獲取體表微循環訊息之多點式光電量測設備’包括: 一光訊號收發單元,係設置複數光發射器及至少一光 接收器,該些光發射器係分別發射一紅外光,該任一光接 收器則接收該些紅外光之反射光; 一切換開關’電性連接該光訊號收發單元,藉以控制 該些光發射器依序發射紅外光; 一接收電路’電性連接該光訊號收發單元,將該任一光接 收器接收之反射光光訊號轉換為電訊號; 一訊號切換器,電性連接該接收電路,並將該電訊號 〇 分類; 一濾波放大電路,電性聲接該訊號切換器,係放大該 電訊號; m鍾· 一核心控制器,電性連接前述切換開關、訊號切換器 及濾波放大電路,該核心控制器係控制該切換開關之切換 頻率,並控制該訊號切換器依據原反射光光訊號之波長而 分類該電訊號,亦將該濾波放大電路放;Ck電訊號轉換為 ..V; ... 數位訊號; 〇 一處理單元,電性連接該核心控制器,並將該數位訊 號運算處理,產生一檢測畫面; 一顯示器’電性連接該處理單元,而輸出該檢測晝面 Ο 5 .如申請專利範圍第4項所述之獲取體表微循環訊息之多點 式光電量測設備,其中該些光發射器呈至少一陣列之排列 ,而該光接收器之數量相同於光發射器陣列之數量,且該 任一光接收器係設置於其所屬該些光發射器之陣列中央。 099128126 表單編號A0101 第13頁/共21頁 0992049466-0 201208648 6 .如申請專利範圍第5項所述之獲取體表微循環訊息之多點 式光電量測設備,其中任一個光接收器與其所屬陣列之任 一個光發射器距離相同。 7 .如申請專利範圍第4項所述之獲取體表微循環訊息之多點 式光電量測設備,另設置一心電量測儀,其電性連接該處 理單元。 8 .如申請專利範圍第7項所述之獲取體表微循環訊息之多點 式光電量測設備,其中該處理單元依據該核心控制器產生 之數位訊號運算處理而產生光體積變化描述波形,該心電 量測儀則量測產生一心電圖訊號,該處理單元進一步由該 光體積變化描述波形及心電圖訊號定義PTTp指標、PTTf 指標及Amp ratio指標之特徵參數,並比對一儲存於該處 理單元之比對參數,而輸出該檢測畫面。 099128126 表單編號A0101 第14頁/共21頁 0992049466-0201208648 VII. Patent application scope: 1. A multi-point photoelectric measuring device for acquiring body surface micro-circulation information, comprising: - an optical signal transceiver unit, which is provided with a complex (four) transmitter and at least one optical receiver' Each of the devices emits an infrared light, and the optical receiver receives the reflected light of the infrared light; a switch is electrically connected to the optical transceiver unit, thereby controlling the light emitters to sequentially emit infrared light; The receiving circuit is connected to the optical signal transceiver unit in a % manner, and converts the reflected optical signal received by any of the optical receivers into a standby electrical signal; the signal switch is electrically connected to the receiving circuit, and classifies the electrical signal; and a filtering and amplifying circuit, Electrically connecting the mirror switch to amplify the electrical signal; a core controller electrically connecting the switch, the signal switch and the filter amplifier circuit. The core controller controls the switching frequency of the switch and controls The signal switcher classifies the electrical signal according to the wavelength of the original reflected light optical signal. Converted into digital signals. 2) A multi-point photoelectric measuring device for obtaining a surface microcirculation message as described in the scope of the patent application, wherein the light emitters are arranged in at least one array and the number of the light receivers is the same as the light The number of emitter arrays, and any one of the light receivers is disposed in the center of the array to which the light emitters belong. 3. A multi-point photoelectric measuring device for acquiring a surface microcirculation message as described in claim 2, wherein any one of the optical receivers is at the same distance from any of the light emitters of the array to which it belongs. 099128126 Form No. A0101 Page 2 of 21 Page 0992049466-0 201208648 4. A multi-point photoelectric measuring device for obtaining surface microcirculation messages includes: an optical signal transceiver unit that sets a plurality of light emitters and at least An optical receiver, each of which emits an infrared light, and the optical receiver receives the reflected light of the infrared light; a switch switch electrically connects the optical signal transceiver unit to control the light emission The device sequentially emits infrared light; a receiving circuit is electrically connected to the optical signal transceiver unit, and converts the reflected optical signal received by any of the optical receivers into an electrical signal; a signal switch is electrically connected to the receiving circuit, and The electric signal is classified as: a filter amplifying circuit, electrically connected to the signal switcher to amplify the electric signal; m clock · a core controller electrically connected to the switch, the signal switch and the filter amplifying circuit, The core controller controls the switching frequency of the switch, and controls the signal switch to classify according to the wavelength of the original reflected light signal The electrical signal is also inserted into the filter amplifying circuit; the Ck electrical signal is converted into a ..V; ... digital signal; a processing unit is electrically connected to the core controller, and the digital signal is processed to generate a Detecting a screen; a display is electrically connected to the processing unit, and outputting the detection surface Ο 5 . The multi-point photoelectric measuring device for obtaining a surface microcirculation message according to claim 4 of the patent application, wherein the The light emitters are arranged in at least one array, and the number of the light receivers is the same as the number of light emitter arrays, and any one of the light receivers is disposed in the center of the array to which the light emitters belong. 099128126 Form No. A0101 Page 13 of 21 0992049466-0 201208648 6. A multi-point photoelectric measuring device for acquiring surface microcirculation messages as described in claim 5, wherein any one of the optical receivers Any one of the arrays has the same distance. 7. A multi-point photoelectric measuring device for obtaining a surface microcirculation message according to item 4 of the patent application, and a core measuring device electrically connected to the processing unit. 8. The multi-point photoelectric measuring device for acquiring a surface microcirculation message according to claim 7, wherein the processing unit generates a light volume change description waveform according to the digital signal processing process generated by the core controller, The electrocardiograph measures the ECG signal, and the processing unit further defines the PTTp index, the PTTf index and the Amp ratio indicator by the optical volume change description waveform and the electrocardiogram signal, and compares and stores the characteristic parameters in the processing. The unit compares the parameters and outputs the detection screen. 099128126 Form No. A0101 Page 14 of 21 0992049466-0
TW99128126A 2010-08-23 2010-08-23 Multi-point optical measurement device and equipment for measuring a microcirculation on a body surface TW201208648A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI493169B (en) * 2013-01-18 2015-07-21 Univ Nat Cheng Kung Optical system for evaluating concentration and distribution of skin parameter and method thereof
CN109475315A (en) * 2016-12-30 2019-03-15 英华达(南京)科技有限公司 Wearable heart monitoring apparatus, cardiac monitoring systems and method
US10444067B2 (en) 2014-10-31 2019-10-15 Industrial Technology Research Institute Optical sensing apparatus and measuring method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI493169B (en) * 2013-01-18 2015-07-21 Univ Nat Cheng Kung Optical system for evaluating concentration and distribution of skin parameter and method thereof
US9345431B2 (en) 2013-01-18 2016-05-24 National Cheng Kung University Method and optical system for evaluating concentrations of components in tissue
US10444067B2 (en) 2014-10-31 2019-10-15 Industrial Technology Research Institute Optical sensing apparatus and measuring method thereof
CN109475315A (en) * 2016-12-30 2019-03-15 英华达(南京)科技有限公司 Wearable heart monitoring apparatus, cardiac monitoring systems and method
US11504040B2 (en) 2016-12-30 2022-11-22 Inventec Appliances (Jiangning) Corporation Wearable heart monitoring device, heart monitoring system and method

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