201127424 六、發明說明： 【發明所屬之技術領域】 本發明通常關於一種清洗隱形眼鏡之領域，及更特定言 之對隱开> 眼鏡進行消毒及使其在消毒完成時適合戴入眼内 之水性過氧化氫溶液之分解。 【先前技術】 目前隱形眼鏡係常見的物品，但是由於需要清洗及存在 嚴重眼疾之風險’鏡片需要定期清洗。蛋白質及可能來自 其他來源之污染物的累積通常係鏡片佩戴者所關心的問 題，因此清洗方便且徹底相當重要。但是，鏡片之清洗通 常係耗時、需要小心處理、複雜及昂貴的過程。爲了使此 等鏡片在佩戴後得到有效清洗，重要的係將所有污染物自 鏡片表面及内部移除。 目刖，存在若干不同的可使使用者在每次佩戴之間清洗 及消毒隱形眼鏡之慣用系統及方法。可將此等慣用的清洗 及消毒系統分為「熱」&「冷」系統。熱系統需要加熱以 對fe形眼鏡騎消毒m統在環境溫度下使用化學消 毒劑以對鏡片進行消毒。 ，在冷4 f範圍内’系統係過氧化氫消毒系統。過氧化氣 消毒液y有效殺死可污染隱形眼鏡之細菌及真菌。已記錄 過氧化氫係用於隱形目&鏡以殺死任何污染微生物之有效藥 劑*所周知，過氧化氣在約3〇秒内渗透鏡片，氧化任何 存在於鏡片表面之黏蛋白且同時係對於任何存在於眼内微 生物之有效$ ’劑是’除非移除在經;肖毒之隱形眼鏡 15l252.doc 201127424 上殘留之過氧化氫’否則該過氧化氫可對眼睛產生刺激、 灼熱或創傷。因此，需要移除經消毒隱形眼鏡上殘留之過 氧化氫以能夠安全及舒適地佩戴經消毒之隱形眼鏡。 隱形眼鏡清洗之另一問題係諸多軟性鏡片係親水性，且 在常用過氧化氫溶液中消毒鏡片時間過長或過短可能導致 額外的問題。若時間過短，將不能充分清洗鏡片，而時間 過長’使鏡片變軟並減少其使用壽命。 在將鏡片戴入眼内之前，經某些無觸媒過氧化氫處理之 軟性隱形眼鏡應以等滲緩衝鹽水沖洗以移除任何殘留的過 氧化氫。在杈佳處理約6小時後，多數經無觸媒過氧化氫 處理之隱形眼鏡具有較高百萬分之過氧化氫殘留濃度。在 此等無觸媒過氧化氫處理系統中，過氧化氫濃度會高於 200 ppm或較佳⑽ppm之通常可接受之臨限值。等渗緩衝 鹽水係緩衝至pH為6.9至7]且利用〇〇〇1%硫柳汞及〇 ι%乙 胺四乙g夂一納（dls〇diUm edatate)保存之〇 85重量％氯化 鈉溶液。若特別敏感，即使極小量（諸如· ppm或較佳 ⑽ppm)過氧化氫可能導致眼部刺激。由於沖洗僅具有將 過氧化氫連續稀釋至較低濃度之作用，如目前實踐之以等 渗緩衝鹽水重複浸泡及沖洗通常不能有效移除所存在之所 有k氧化A 0此’經沖洗之軟性隱形眼鏡仍可能殘留足 以刺激佩戴者之過氧化氫之濃度。 充分沖洗亦具有其他問題。主要問題之—係其需要過多 的時間及個人關注以進行充分的沖洗步驟。對於充分浸泡 及冲洗順序而t，已發現需要四次不同的沖洗。在必須中 151252.doc 201127424 間浸泡之情況下’可接受的過程將花費約3〇分鐘或更多。 另一缺點在於沖洗步驟及順序通常非常主觀且缺乏再現 性’因此不同人之間該等沖洗步驟及順序的有效性存在較 大差異。此外’需要較大體積之鹽水溶液以進行充分沖洗 步驟，其使實踐較繁瑣及不便。 爲了增強使用者之順應性且方便使用，對單一步驟消毒 及過氧化氫中和做出諸多努力。在此方面，將圖1顯示之 經祐塗佈之三角盤（即觸媒）加至含有過氧化氫之液體水性 介質與待消毒之隱形眼鏡的容器中。此特性極大地減少了 使用者有效消毒鏡片及中和殘留的過氧化氫所需之時間及 心力。提供較佳的使用者順應性及較高的使用者眼睛安全 程度。儘管目前的過氧化物系統滿足IS〇標準，但希望增 加效力。 【發明内容】 在實例實施例中，本發明提供一種中和來自經過氧化氫 消毒之軟性隱形眼鏡的過氧化氫之方法及裝置。 在一態樣中，本發明係中和來自經過氧化氫消毒之軟性 隱形眼鏡的過氧化氫之方法。此方法包含將軟性隱形眼鏡 置於水性過氧化氫消毒液中，將經觸媒塗佈之圓盤置於水 性過氧化氫消毒液中，其中該經觸媒塗佈之圓盤具有中和 過氧化物觸媒之作用，及使隱形眼鏡維持在溶液中直至存 在於水性過氧化氫消毒液中之過氧化氫低於可導致灼熱/ 刺痛及/或角膜刺激之》辰度（諸如小於2〇〇 或較佳1〇〇 PPm) °該輻射狀圓盤較佳具有2 〇 cm2至9.0 cm2之間之表 151252.doc 201127424 面積。 在另一態樣中，本發明係關於一種過氧化氫觸媒裝置， 其影響為隱形眼鏡提供消毒之水性過氧化氫消毒液之中 和’且使隱形眼鏡在完成消毒時適合戴入眼内。該裝置包 含具有表面積約2·〇 cm2至9.0 cm2之輻射狀圓盤。該二 狀圓盤進一步包含觸媒塗層，該觸媒塗層在第-小時處理 期間將高濃度過氧化氫遞送至隱形眼鏡。 时照本文圖形料細描述，及將藉由諸多在附屬申請 專利範圍中特別指屮+ -主 子另】札出之兀素及組合瞭解本發明之此等及並 他態樣、特性及優點。庵蝽 一 -應瞭解本發明上文一般描述及下文 圖示簡單描述及本發 1月6平細描述兩者係本發明較佳實施例 之示例及解释，且不限制所主張之本發明。 【實施方式】 釔口附圖（其形成本揭示内容之部分）參照以下本發明之 述可更容易理解本發明。應瞭解本發明不限於本文 ,… 裝置、方法、條件或參數，且本文 係僅藉由舉例用於描述特定實施例之目的而 =1之本發明ι說明書中識別之任何及所有專 利及其他公開案係以引料方式併人本文中。 同樣，如包括附屬申过 之單數形式「― β專财請範圍之說明書中所使用 至少包括該特定值，2包括複數，且提及之特定數值 可表示為自「約：非本文另外明確指明。本文之範圍 約」—特定值及/或至…約另一特 當表示該範圍時，另一〜 ]」力特疋值 只把例包括自一特定值及/或至其 151252.doc s 201127424 他特定值。同樣，當葬出蚀田止— 「 碏由使用先仃5司約」使數值表示為 近似值時，將瞭解該特定值形成另一實施例。 本發明適於對所有類型之藉由該消毒方法獲益之隱形眼 鏡進行消毒。該等鏡片（例如，慣用軟性隱形眼鏡、RGP及 S·鏡片)可由任何合適的材料或材料之組合製成且可具 有任何合適的構型。 本發明之溶液包含適用於消毒 月毋目的之濃度，較佳約0.5 ㈣至約6重量更佳約2重量％至約6重量％，最佳3重 夏％及4重量％之間，或約3重量％之過氧化氫。 '如：文所使用之術語「殘留的過氧化氫濃度增加」意指 當在谷盗中與固定體積之相同過氧化氯溶液接觸時，殘留 的過氧化氫濃度相對於對照組輕射狀圓盤增加，該對昭电 輻射狀圓盤具有10.4 cm2之美柘主二〜 、 之基板表面及實質上相同的觸媒 塗層重量/表面積，盆中兮 “中該輻射狀圓盤係置於容器中以與 水性過氧化氫溶液接觸。由於圓盤之表面積比對照組輪射 狀圓盤小，將所增加之殘留過氧化氫濃度之百分率定義為 [(C6°“時所減少之表面積_C6❶分“之对”盤Vc6。分"之對照组）]><100之 比率；所減少…積係當固定體積之過氧化氯於室溫 下在塑料容器中與經觸媒塗佈之圓盤(表面積比對照組圓盤 小）接觸6G分鐘時所敎之殘留過^氫濃度。‘ 係當固定體積之相同過氧化氫溶液於室溫下在相同塑料容 器令與經相同觸媒塗佈之對照圓盤接觸6〇分鐘時所測定之 殘留過乳化氫漠度。固定體積係能夠完全浸沒觸媒且係約 至25^，較佳7cm^l8cm3，更佳8咖3至13 151252.doc 201127424 :m ’ ’別佳9 cm3至11 cm3。過氧化氫溶液包含過氧化 虱，且可包括其他用於隱形眼鏡護理液之合適成份，例如 表面活性劑、緩衝液、滲透劑。 根據本發明，術語「觸媒」意指可催化過氧化氫分解之 任何材料。該觸媒較佳係固態，及更佳係來自周期表3至 12族之過渡金屬之金屬或金屬氧化物或鑭系元素之金屬或 金屬氧化物。特別佳係鉑、鐵或鈦，更特定言之係氧化 鉑根據本發明，術語「基板」意指任何塑料材料。較佳 的塑料材料具有以下材料特性：良好的尺寸穩定性'水解 女疋性及低至無吸水性，例如，縮醛（DAin⑧， Celcon®)、CPVC、Engage⑧、⑧、 (PVDF)、Lexan®(PC)、Noryl®(PPE)、聚苯乙烯（PS)、聚 丙烯（PP)。該塑料材料更佳係Noryl@，經改質聚苯醚。可 使用s亥塑料材料藉由射出成型過程製備本發明之圓盤。本 發明之圓盤可具有光滑表面及粗糙表面。圓盤表面較佳具 有B-2至C-1，更佳具有B3級別之spi(塑料工業協會 (Society of the Plastics Industry))表面光潔度級別。 本發明大致係關於過氧化氫觸媒裝置及方法。本發明係 部分基於以下發現：當在容器中與固定體積之過氧化氫溶 液接觸時，較小的觸媒圓盤可使殘留的過氧化氫濃度相對 於對照組圓盤（具有10.4 cm2之基板表面積及實質上具有相 同的觸媒塗層重量/表面積）增加至少8〇%，較佳至少 100% ’更佳至少500%，進一步更佳1〇〇〇%，其中該輻射 狀圓盤係置於谷益中以與水性過氧化氫溶液接觸。當在塑 151252.doc 5 201127424 料容器中於室溫下使固定舻 门姑 便口疋體積之過氧化氫與具有比對昭紐 盤之表面積小之經觸媒塗佈之圓盤接觸60分鐘時’列定 ^留的過氧化氫濃度。本發明亦邹分基於以下發現：儘管 較小的觸媒圓盤可提#大Φ5掛4 ^。 杈供大巾田增加的殘留過氧化氫濃度 至1000%)(當在塑料容器中 运 τ 、至/Λ下使固定體積之過氧化 氫與具有比對照組圓盤之声而接 圓之表面積小之經觸媒塗佈之圓盤技 觸60分鐘時所測得），作是 ) 疋接觸6小時後殘留過氧化氫之濃 度降至小於200 ppm，更伟inn PP PPm，且㈣過氧化氫觸媒 裝置處理之隱形眼鏡可更舒適地戴入眼内。 本發明提供藉由縮小圓盤之表面積而改良之中和動力 學。目前市售之如表丨所示之三角盤具有約1〇4em2之表面 積與1150叫翻塗層。表！亦提供具有8 7 ‘之表面積盘 _ 始塗層之輻射狀圓# ;另—具有52咖2與649 _ 塗層之輻射狀圓盤。令人驚舒的{，在處理的第—小時及 整個清洗循環期間，較小的經始塗佈之圓盤可將濃度增加 之過氧化氫遞送至隱形眼鏡’因此導致消毒效力整體增 加。此顯示用於消毒隱形眼鏡之過氧化氫消毒液具有8爪】 至18 ml範圍内之體積。在較佳實施例中，過氧化氫消毒 液具有9.5 ml至11_5 ml範圍内之體積。在較佳實施例中， 輻射狀圓盤具有2.0 cm2至9.〇 cm2範圍内之表面積較佳 3.5 Cm2i8.5 cm2範圍内之表面積，更佳5〇邮2至65咖2 範圍内之表面積，更佳5.2 〇^至6.0 cm2範圍内之表面 積。 在較佳實施例中，輻射狀圓盤利用塑料载體且具有2〇〇 151252.doc 201127424 至1000 pg範圍内之觸媒塗層，較佳400 pg至960 範圍 内之觸媒塗層，更佳500 pg至700 pg範圍内之觸媒塗層， 特別佳600 pg至650 pg範圍内之觸媒塗層。 由塗層重量/表面積之觀點而言，在較佳實施例中，該 圓盤具有觸媒塗層重量/表面積係60 μ g/cm2至250 pg/cm2’ 較佳 90 μ§/οιη2至 135 pg/cm2’ 更佳 100 pg/cm2至 125 pg/cm ° 6小時後，殘留的過氧化物濃度仍保持在可導致灼熱/刺 痛及/或角膜刺激之濃度以下。 表1 殘留的H202濃度 表面積 實際測 量濃度 目前市售之三角盤 10.4 cm2 1小時 177 ppm 6小時 1.93 ppm 新穎(表面積改變)輻射狀圓盤 8.7 cm2 360 ppm 4.8 ppm 高度改變50%之輻射狀圓盤 5.2 cm2 1800 ppm 25 ppm 此外，本發明提供使用相對簡單及直接之塗料組合物之 經觸媒覆蓋之輻射狀圓盤，其易於製造目前的組合物且降 低使用該等組合物可能導致之潛在問題之數量。製備組合 物所使用之方法提供高度均勻之塗層，且因此相當可靠地 提供所希望之過氧化氫降解動力學。 在一廣泛態樣中，本發明係關於一種用於處理軟性隱形 眼鏡以影響該隱形眼鏡之消毒及使其在完成消毒時適合戴 入眼内之方法。該方法包含：（1)將軟性隱形眼鏡置於水性 過氧化氫溶液中；（2)將經觸媒塗佈之圓盤置於過氧化物溶201127424 VI. INSTRUCTIONS OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention generally relates to the field of cleaning contact lenses, and more particularly to the cloaking of glasses and the suitability of the lenses to be worn into the eye upon completion of sterilization. Decomposition of hydrogen peroxide solution. [Prior Art] Currently, contact lenses are common items, but because of the need to clean and the risk of serious eye diseases, the lenses need to be cleaned regularly. Accumulation of proteins and contaminants that may come from other sources is often a concern for lens wearers, so cleaning is convenient and thorough. However, lens cleaning is often a time consuming process that requires careful handling, complexity, and expense. In order for these lenses to be effectively cleaned after wearing, it is important to remove all contaminants from the lens surface and inside. It is apparent that there are a number of different conventional systems and methods that allow a user to clean and disinfect contact lenses between each wear. These conventional cleaning and disinfection systems can be divided into "hot" & "cold" systems. The thermal system requires heating to sterilize the lens by using a chemical disinfectant at ambient temperature. In the cold 4 f range, the system is a hydrogen peroxide disinfection system. Peroxide gas Disinfectant y effectively kills bacteria and fungi that can contaminate contact lenses. Hydrogen peroxide has been documented for use in stealth & mirrors to kill any effective agent that contaminates microorganisms. * It is well known that peroxidic gas penetrates the lens in about 3 seconds and oxidizes any mucin present on the surface of the lens. For any effective microbes present in the eye, the agent is 'unless removed from the hydrogen peroxide remaining on the lens; the poisonous hydrogen peroxide can cause irritation, burning or trauma to the eye. . Therefore, it is necessary to remove the residual hydrogen peroxide on the sterilized contact lens to safely and comfortably wear the sterilized contact lens. Another problem with contact lens cleaning is that many flexible lenses are hydrophilic, and sterilizing the lens in conventional hydrogen peroxide solutions for too long or too short may cause additional problems. If the time is too short, the lens will not be adequately cleaned, and the time is too long to soften the lens and reduce its service life. Soft contact lenses treated with some non-catalytic hydrogen peroxide should be rinsed with isotonic buffered saline to remove any residual hydrogen peroxide prior to wearing the lens into the eye. After about 6 hours of treatment, most of the contact lens treated with no catalyst hydrogen peroxide has a higher residual concentration of hydrogen peroxide. In such a catalyst-free hydrogen peroxide treatment system, the hydrogen peroxide concentration will be above the generally acceptable threshold of 200 ppm or preferably (10) ppm. Isotonic buffer saline was buffered to a pH of 6.9 to 7] and was stored in 〇85% by weight sodium chloride solution using 〇〇〇1% thiomersal and ι% ethylamine tetraglycidyl hydride (dls〇diUm edatate). If it is particularly sensitive, even a very small amount (such as · ppm or preferably (10) ppm) of hydrogen peroxide may cause eye irritation. Since flushing only has the effect of continuously diluting hydrogen peroxide to a lower concentration, as in the current practice, repeated soaking and rinsing with isotonic buffered saline usually does not effectively remove all of the k-oxidized A 0 present. This is a soft invisible rinse. The lens may still remain at a concentration sufficient to stimulate the wearer's hydrogen peroxide. Flushing well has other problems. The main problem is that it requires too much time and personal attention to perform adequate rinsing steps. For adequate soaking and rinsing sequences, it has been found that four different rinses are required. In the case of a immersion between 151252.doc 201127424, the acceptable process would take approximately 3 minutes or more. Another disadvantage is that the rinsing steps and sequence are often very subjective and lack reproducibility' so there is a large difference in the effectiveness of such rinsing steps and sequences between different people. In addition, a larger volume of saline solution is required to perform a sufficient rinsing step, which makes the practice cumbersome and inconvenient. In order to enhance user compliance and ease of use, many efforts have been made to neutralize single-step disinfection and hydrogen peroxide. In this regard, the coated triangular disk (i.e., catalyst) shown in Figure 1 is added to a container containing a liquid aqueous medium of hydrogen peroxide and a contact lens to be sterilized. This feature greatly reduces the time and effort required for the user to effectively disinfect the lens and neutralize residual hydrogen peroxide. Provides better user compliance and higher eye safety for the user. Although current peroxide systems meet the IS〇 standard, it is desirable to increase efficacy. SUMMARY OF THE INVENTION In an illustrative embodiment, the present invention provides a method and apparatus for neutralizing hydrogen peroxide from a hydrogen peroxide sterilized soft contact lens. In one aspect, the invention is a method of neutralizing hydrogen peroxide from a hydrogen peroxide sterilized soft contact lens. The method comprises placing a soft contact lens in an aqueous hydrogen peroxide disinfectant, and placing the catalyst coated disc in an aqueous hydrogen peroxide disinfectant, wherein the catalyst coated disc has a neutralization The role of the oxide catalyst, and maintaining the contact lens in solution until the hydrogen peroxide present in the aqueous hydrogen peroxide disinfectant is below the level that can cause burning/stinging and/or corneal irritation (such as less than 2) 〇〇 or preferably 1 〇〇 PPm) ° The radial disk preferably has a surface of 151252.doc 201127424 between 2 〇 cm 2 and 9.0 cm 2 . In another aspect, the present invention is directed to a hydrogen peroxide catalyst device that provides for the disinfection of a water-based hydrogen peroxide disinfectant solution for a contact lens and that allows the contact lens to be worn into the eye when the sterilization is completed. The apparatus comprises a radial disc having a surface area of from about 2 〇 cm 2 to 9.0 cm 2 . The two-disc further comprises a catalyst coating that delivers a high concentration of hydrogen peroxide to the contact lens during the first hour of treatment. The present invention will be described in detail in the drawings, and the various aspects, features, and advantages of the present invention will be understood by the various elements and combinations in the scope of the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS The foregoing description of the preferred embodiments of the invention and the claims [Embodiment] The present invention can be more easily understood by referring to the following description of the invention. It is to be understood that the invention is not to be construed as being limited to the details of the invention, the invention, the The case is based on the method of introduction. Similarly, if the singular form “including the singular form of the affiliation is included, the singular use of the stipulations includes at least the specific value, 2 includes the plural, and the specific value mentioned may be expressed as “from: not specified otherwise in this document. The scope of this document is "about" - a specific value and / or to ... about another special when the range is expressed, another ~ ] " force 疋 value only includes examples from a specific value and / or to its 151252.doc s 201127424 His specific value. Similarly, when the burial field is stopped - "碏" is used to approximate the value, it will be understood that the specific value forms another embodiment. The present invention is suitable for disinfecting all types of invisible eye lenses that benefit from the sterilization process. The lenses (e.g., conventional soft contact lenses, RGP and S. lenses) can be made of any suitable material or combination of materials and can have any suitable configuration. The solution of the present invention comprises a concentration suitable for disinfecting the future, preferably from about 0.5 (four) to about 6 by weight, more preferably from about 2% by weight to about 6% by weight, most preferably between 3% by weight and 4% by weight, or about 3 wt% hydrogen peroxide. 'Example: The term "increased residual hydrogen peroxide concentration" as used herein means that when in contact with a fixed volume of the same chlorine peroxide solution in the grain thief, the residual hydrogen peroxide concentration is lighter than the control group. The disc is increased, and the pair of Zhaodian radial discs have a surface of 10.4 cm2 of the main bismuth, the surface of the substrate and substantially the same catalyst coating weight/surface area, and the radiant disc in the bowl is placed in the container. In contact with the aqueous hydrogen peroxide solution, since the surface area of the disk is smaller than that of the control group, the percentage of the residual hydrogen peroxide concentration is defined as [(C6°" reduced surface area _C6❶) Divided into "the right" disk Vc6. The control group of the branch "><100 ratio; reduced...the system is coated with a fixed volume of peroxidized chlorine in a plastic container at room temperature. The residual hydrogen concentration of the disc (the surface area is smaller than that of the control disc) was contacted at 6 G minutes. ‘ Residual over-emulsified hydrogen inversion as measured by a fixed volume of the same hydrogen peroxide solution at room temperature in the same plastic container for 6 minutes with the same catalyst coated control disc. The fixed volume is capable of completely immersing the catalyst and is about 25 cm, preferably 7 cm ^ 18 cm 3 , more preferably 8 coffee 3 to 13 151252.doc 201127424 : m ' ' 别佳 9 cm3 to 11 cm3. The hydrogen peroxide solution contains cerium peroxide and may include other suitable ingredients for use in contact lens care solutions, such as surfactants, buffers, penetrants. According to the invention, the term "catalyst" means any material which catalyzes the decomposition of hydrogen peroxide. The catalyst is preferably a solid, and more preferably a metal or metal oxide or a lanthanide metal or metal oxide derived from a transition metal of Groups 3 to 12 of the periodic table. Particularly preferred is platinum, iron or titanium, more particularly oxidized platinum. According to the invention, the term "substrate" means any plastic material. Preferred plastic materials have the following material properties: good dimensional stability 'hydrolyzed virginity and low to no water absorption, for example, acetal (DAin8, Celcon®), CPVC, Engage 8, 8, (PVDF), Lexan® (PC), Noryl® (PPE), polystyrene (PS), polypropylene (PP). The plastic material is better than Noryl@, modified polyphenylene ether. The disc of the present invention can be prepared by an injection molding process using shai plastic material. The disc of the present invention can have a smooth surface and a rough surface. The disc surface preferably has a B-2 to C-1, more preferably a B3 grade spi (Society of the Plastics Industry) surface finish level. The present invention generally relates to a hydrogen peroxide catalyst device and method. The present invention is based in part on the discovery that a smaller catalyst disk can maintain a residual hydrogen peroxide concentration relative to a control disk (with a substrate of 10.4 cm2) when in contact with a fixed volume of hydrogen peroxide solution in a vessel. The surface area and substantially the same catalyst coating weight/surface area increase by at least 8%, preferably at least 100% 'more preferably at least 500%, further preferably 1%, wherein the radial disc is ligated Yu Guyi is in contact with an aqueous hydrogen peroxide solution. When in the plastic 151252.doc 5 201127424 material container, the hydrogen peroxide of the fixed sputum volume is contacted at room temperature for 60 minutes with the catalyst coated disc having a smaller surface area than the mirror plate. When the time is set, the hydrogen peroxide concentration is retained. The present invention is also based on the following findings: although a smaller catalyst disk can be raised #大Φ5挂4^.增加 Increase the residual hydrogen peroxide concentration in the large towel field to 1000%) (When the volume of hydrogen peroxide is applied to the plastic container, the fixed volume of hydrogen peroxide is combined with the surface area of the control disc. The measurement of the small catalyst-coated disc touched for 60 minutes), the concentration of residual hydrogen peroxide after 6 hours of contact reduced to less than 200 ppm, more inn PP PPm, and (iv) peroxidation The contact lens treated by the hydrogen catalyst device can be worn into the eye more comfortably. The present invention provides improved neutralization kinetics by reducing the surface area of the disk. The commercially available triangular discs as shown in Table 具有 have a surface area of about 1 〇 4 cm 2 and a 1150 coating. table! A radial circle with a surface area of 8 7 ‘the initial coating is also provided; and a radial disk with a coating of 52 coffee 2 and 649 _ is also provided. Surprisingly, a smaller, initially coated disc can deliver an increased concentration of hydrogen peroxide to the contact lens during the first hour of treatment and throughout the cleaning cycle' thus resulting in an overall increase in disinfecting efficacy. This shows that the hydrogen peroxide disinfectant used to disinfect contact lenses has a volume ranging from 8 claws to 18 ml. In a preferred embodiment, the hydrogen peroxide disinfecting solution has a volume in the range of 9.5 ml to 11_5 ml. In a preferred embodiment, the radial disk has a surface area in the range of 2.0 cm 2 to 9. 〇 cm 2 , preferably a surface area in the range of 3.5 Cm 2 i 8.5 cm 2 , more preferably a surface area in the range of 5 〇 2 to 65 咖 2 , More preferably 5.2 表面积^ to a surface area in the range of 6.0 cm2. In a preferred embodiment, the radial disk utilizes a plastic carrier and has a catalyst coating in the range of 2,151,252.doc 201127424 to 1000 pg, preferably a catalyst coating in the range of 400 pg to 960, Catalyst coatings in the range of 500 pg to 700 pg, especially catalyst coatings in the range of 600 pg to 650 pg. From the viewpoint of coating weight/surface area, in a preferred embodiment, the disk has a catalyst coating weight/surface area of 60 μg/cm 2 to 250 pg/cm 2 ' preferably 90 μ§/οιη2 to 135 Pg/cm2' more preferably from 100 pg/cm2 to 125 pg/cm ° After 6 hours, the residual peroxide concentration remains below the concentration that can cause burning/stinging and/or corneal irritation. Table 1 Residual H202 Concentration Surface Area Actual Measurement Concentration Currently commercially available triangular disc 10.4 cm2 1 hour 177 ppm 6 hours 1.93 ppm Novel (surface area change) radial disc 8.7 cm2 360 ppm 4.8 ppm Radial disc with 50% height change 5.2 cm2 1800 ppm 25 ppm Furthermore, the present invention provides a catalyst-coated radial disc that uses relatively simple and straightforward coating compositions that are easy to manufacture from current compositions and that reduce potential problems associated with the use of such compositions The number. The method used to prepare the composition provides a highly uniform coating and thus provides the desired hydrogen peroxide degradation kinetics fairly reliably. In one broad aspect, the present invention is directed to a method for treating a soft contact lens to effect sterilization of the contact lens and to fit it into the eye when the sterilization is completed. The method comprises: (1) placing a soft contact lens in an aqueous hydrogen peroxide solution; (2) placing the catalyst coated disk in a peroxide solution
S 151252.doc -11 - 201127424 液中’其中該觸媒塗佈之圓般1 圓盜具有中和過氧化物觸媒之作 用，且具有2.0 cm2至9 〇 cm2本 之表面積；及（3)使該隱形眼 鏡維持在該溶液中直至存扃夕、A於 仔在之過乳化虱低於可導致灼熱/ 刺痛及/或角膜刺激之濃度。因此，中和發生後，經消毒 之隱形眼鏡可自液體水性介質中移除並直接戴入眼内。 在另：T把例中’本發明係關於一種製備用於中和含有 過氧化氫之液體水性介質中之殘留過氧化氮之過氧化氮觸 媒糸統之方法。此方法包含至少一具有表面積約2 〇。爪2至 9.〇 cm2之物品，提供令和過氧化氫之觸媒，例如麵；及塗 佈具有過氧化氫破壞組分之物品而使其可有效中和存在於 介質中之過氧化物。 在另貝施例中，本發明係關於一種過氧化氫觸媒裝 置，其實現為隱形眼鏡提供消毒作用之水性過氧化氩消毒 液之中和且使隱形眼鏡在消毒完成時適於戴入眼内。該裝 置包含具有表面積約2.0 cm2至9.〇 cm2之輻射狀圓盤。該 輻射狀圓盤進一步包含2〇〇 至9〇〇叫之觸媒塗層，其在 處理弟小時期間，使隱形眼鏡消毒效力增強。在較佳實 施例中’該輻射狀圓盤具有2.〇 至9.〇 cm2範圍内之表 面積，更佳3·5 cm2至8.5 cm2範圍内之表面積，更佳5 〇 cm2至6.5 cm2範圍内之表面積，特別佳5 2 cm2s6 〇 cm2範 圍内之表面積。在較佳實施例中，該輻射狀圓盤具有2〇〇 至〗000叫範圍内之觸媒塗層，較佳4〇〇叫至96〇叫範圍 内之觸媒塗層，更佳5〇〇叫至700叫範圍内之觸媒塗層， 特別佳600 至650叫範圍内之觸媒塗層。在另一較佳實 15J252.doc 12 201127424 施例中’該圓盤具有觸媒塗層重量/表面積係60 Mg/cm2至 250 pg/cm2 ’ 較佳 90 pg/cm2 至 135 pg/cm2，更佳 100 pg/cm2至 125 pg/cm2。 現在參照附圖，這數個圖當中之相似參考數字表示相應 部分。圖1顯示先前技術之輻射狀觸媒圓盤15之俯視圖。 該輕射狀觸媒圓盤包含一般為中空及環形、齒輪狀主體。 該觸媒圓盤係經成形以協同安裝入圓柱形容器之底部中。 該等圓柱形容器係在此項技術中已知，且實例提供於U s 5,1 96,1 74，將其揭示内容以引用的方式併入本文中。 圖2顯不根據本發明一實例實施例之輻射狀觸媒圓盤 之俯視圖如圖所示，該輻射狀圓盤20自核心以放射狀延 伸數個臂。如所顯示之輻射狀圓盤20具有相似的一般為中 空、％幵>、齒輪形狀，但是表面積較先前技術之三角盤減 表面積減小之輻射狀圓盤與過氧化氫之反應較慢， 匕在/月洗程序初期維持較高濃度之過氧化氫，同時仍將 戔留匕氧化氫降至可導致灼熱’刺痛及/或角膜刺激之濃度 以下。圖6中顯示輻射狀觸媒圓盤之透視圖。 一二A系輻射狀觸媒圓盤之俯視圖，該圓盤具有相似的 ’’、、中二％形 '齒輪形狀，但是利用諸多改變以降低 二積而使其比先前技術之輻射狀圓盤觸媒之表面積小。 = = = =狀觸媒圓盤I此導致表面 盤4。，以使表面積進二少=肖_?輻射狀觸媒圓 有末端削為正方…二；7。在圖5中，顯示具 ，，刀削是之輻射狀觸媒圓盤5〇。此導 151252.doc •13· 201127424 致表面積為7.57 cm2 ^此等圍繞相似的核心物品之多種設 计使得能發揮本發明輻射狀圓盤之先進效用。以此方式， 可對每種不同類型之過氧化氫消毒液建議合適的輻射狀圓 盤構型。 在另一實施例中’高度減少之輻射狀觸媒圓盤6〇的表面 積減少最多。輻射狀圓盤60之高度降至輻射狀圓盤2〇高度 之5%至90%範圍内之尺寸。此導致表面積為1.967 cm2至 8‘02ό cm2。圖7顯示輻射狀圓盤之高度減少約5〇%，及此 導致表面積為5.174 cm2。在中和過氧化氫清洗溶液期間， 此減少對於圓盤過氧化物降解動力學有巨大影響。 圖8 A至8E闡述以上描述之輻射狀圓盤及循環後殘留過 氧化氫濃度之比較。顯示對於20、30、60、12〇及360分鐘 之時間增量之浸沒在Clear Care™溶液中之表面積改變之 輻射狀觸媒圓盤20至40及60各者的殘留過氧化氫濃度。最 初Clear Care™溶液中之過氧化氫濃度係約35,000 ppm。 如圖8 A所示，初始過氧化氫濃度在約20分鐘後進行快速 催化中和。20分鐘後，輕射狀圓盤20中和過氧化氫至約 2000 ppm。此係與催化中和作用減低之輻射狀圓盤30、40 及60相比。缺少2臂之輻射狀圓盤30導致過氧化氫濃度約 4000 ppm，缺少4臂之輻射狀圓盤40導致過氧化氫濃度約 4100 ppm及高度改變50%之輻射狀圓盤60導致過氧化氫濃 度約 10,000 ppm。 圖8B闡述循環30分鐘後使用20至40及60輻射狀圓盤之過 氧化氫濃度，各輻射狀圓盤之測量結果分別係約1000 I51252.doc •14- 201127424 ppm、2000 ppm、2500 ppm及 7800 ppm ° 圖8C闡述循環約60分鐘後所測得之各輻射狀圓盤2〇至5〇 之過氧化氫濃度。各輻射狀圓盤20至40及60之過氧化氫濃 度分別係約150、250、600及1750 ppm。可以看出，輻射 狀圓盤表面積之減少對中和消毒液中之過氧化氫產生較大 影響。觸媒塗佈之圓盤之表面積越小，中和作用越慢。 圖8D闡述循環120分鐘後使用20至40及60輻射狀圓盤之 過氧化氣濃度’各輻射狀圓盤之測量結果分別係約8〇 ppm ' 200 ppm、500 ppm及 650 ppm ° 圖8E表示輻射狀圓盤20至4〇及6〇循環6小時後所測試之 Clear Care ’谷液中之過氧化氫值尚度降低。輕射狀圓盤 20之殘留的過氧化氫含量係低於2〇 ppm。該結果表明當使 用Clear Care™溶液時，輻射狀圓盤2〇之殘留過氧化氫濃 度係約為先前技術三角盤15之濃度。移除2臂之輻射狀圓 盤之殘留過氧化氫濃度係約13 ppm。因此，在鏡片循環後 輻射狀圓盤20及3G將不會增加與殘留高濃度過氧化物相關 之灼熱及刺痛之風險，並將保持有效的系統。 但疋’移除4臂之輻射狀圓盤之殘留過氧化氫濃度係約 b ppm，及具有輕射狀圓盤2〇 一半厚度之輕射狀圓_ 約25 ppm。使用輻射狀圓盤4〇或輻射狀圓盤6〇應不會增加 與殘留高濃度過氧化物相關之灼熱及刺痛風險。θ 媒1氧Μ之中和速率係取決於所提供之觸 、…’員而易見的。因此，可藉由增加或降低所使用 經觸媒塗佈之輕射狀圓盤之表面積達到任何所希望的過氧S 151252.doc -11 - 201127424 In the liquid, the round 1 thief coated with the catalyst has the function of neutralizing the peroxide catalyst and has a surface area of 2.0 cm 2 to 9 〇 cm 2 ; and (3) The contact lens is maintained in the solution until the time when the emulsification is less than the concentration that can cause burning/stinging and/or corneal irritation. Thus, after neutralization occurs, the sterilized contact lens can be removed from the liquid aqueous medium and worn directly into the eye. In another embodiment, the present invention relates to a process for preparing a nitrogen peroxide catalyst system for neutralizing residual nitrogen peroxide in a liquid aqueous medium containing hydrogen peroxide. The method comprises at least one having a surface area of about 2 Torr. An article of the claws 2 to 9. 〇cm2, which provides a catalyst for the hydrogen peroxide, such as a surface; and an article coated with a hydrogen peroxide-destroying component to effectively neutralize the peroxide present in the medium . In another embodiment, the present invention relates to a hydrogen peroxide catalyst device that achieves neutralization of an aqueous argon peroxide disinfectant that provides disinfection for a contact lens and that is suitable for wearing into the eye when the sterilization is completed. . The device comprises a radial disc having a surface area of from about 2.0 cm2 to about 9. cm2. The radial disc further comprises a 2" to 9" squeegee coating which enhances the effectiveness of the contact lens disinfection during the treatment of the younger hour. In a preferred embodiment, the radial disk has a surface area in the range of 2. 〇 to 9. 〇 cm 2 , more preferably a surface area in the range of 3·5 cm 2 to 8.5 cm 2 , more preferably in the range of 5 〇 cm 2 to 6.5 cm 2 . The surface area, particularly preferably in the range of 5 2 cm 2 s6 〇 cm 2 . In a preferred embodiment, the radial disk has a catalyst coating in the range of 2 〇〇 to 10,000, preferably a catalyst coating in the range of 4 〇 to 96 ,, preferably 5 〇. It is squeaked to a catalyst coating in the range of 700, especially in the range of 600 to 650. In another preferred embodiment 15J252.doc 12 201127424, the disk has a catalyst coating weight/surface area of 60 Mg/cm 2 to 250 pg/cm 2 ', preferably 90 pg/cm 2 to 135 pg/cm 2 , more Good from 100 pg/cm2 to 125 pg/cm2. Referring now to the drawings, like reference numerals refer to the Figure 1 shows a top view of a prior art radial catalyst disk 15. The light-acting catalyst disk comprises a generally hollow and annular, gear-like body. The catalyst disc is shaped to cooperatively fit into the bottom of the cylindrical container. Such cylindrical containers are known in the art, and examples are provided in U s 5,1 96,1 74, the disclosure of which is incorporated herein by reference. 2 is a top plan view of a radial catalyst disk in accordance with an exemplary embodiment of the present invention, the radial disk 20 extending radially from the core by a plurality of arms. The radial disk 20 as shown has a similar generally hollow, %幵>, gear shape, but the surface area of the radial disk having a reduced surface area compared to prior art triangular disks has a slower reaction with hydrogen peroxide.维持 Maintain a higher concentration of hydrogen peroxide at the beginning of the / month wash procedure while still reducing the concentration of sputum sputum hydrogen peroxide below the concentration that can cause burning sting and/or corneal irritation. A perspective view of the radial catalyst disk is shown in FIG. A top view of a radial A catalyst disk having a similar '', medium, and %' shaped gear shape, but utilizing a number of changes to reduce the second product to make it more radial than prior art radial disks The surface area of the catalyst is small. = = = = Catalytic disk I This results in the surface disk 4. In order to make the surface area into two less = Xiao _? Radiation-like catalyst circle has the end cut into square ... two; In Fig. 5, the tool is shown, and the blade is a radial catalyst disk 5〇. This guide 151252.doc •13· 201127424 The surface area is 7.57 cm2 ^ These various designs around similar core items enable the advanced utility of the radial disc of the present invention. In this way, a suitable radial disk configuration can be suggested for each different type of hydrogen peroxide disinfectant. In another embodiment, the surface area of the highly reduced radial catalyst disk 6〇 is reduced the most. The height of the radial disk 60 is reduced to a size in the range of 5% to 90% of the height of the radial disk 2〇. This results in a surface area of 1.967 cm2 to 8'02ό cm2. Figure 7 shows that the height of the radial disc is reduced by about 5%, and this results in a surface area of 5.174 cm2. This reduction has a large impact on the peroxide degradation kinetics of the disc during neutralization of the hydrogen peroxide cleaning solution. Figures 8A through 8E illustrate the comparison of the radial discs described above and the residual hydrogen peroxide concentration after cycling. The residual hydrogen peroxide concentration of each of the radial catalyst disks 20 to 40 and 60 immersed in the Clear CareTM solution for a time increment of 20, 30, 60, 12 Torr and 360 minutes is shown. The concentration of hydrogen peroxide in the original Clear CareTM solution is approximately 35,000 ppm. As shown in Fig. 8A, the initial hydrogen peroxide concentration was subjected to rapid catalytic neutralization after about 20 minutes. After 20 minutes, the light-emitting disk 20 neutralized hydrogen peroxide to about 2000 ppm. This is compared to radial discs 30, 40 and 60 which have a reduced catalytic neutralization. The lack of a 2-arm radial disk 30 results in a hydrogen peroxide concentration of about 4000 ppm, and the absence of a 4-arm radial disk 40 results in a hydrogen peroxide concentration of about 4100 ppm and a height change of 50% of the radial disk 60 resulting in hydrogen peroxide. The concentration is approximately 10,000 ppm. Figure 8B illustrates the hydrogen peroxide concentration of 20 to 40 and 60 radial discs after 30 minutes of cycling. The measurement results for each radial disc are approximately 1000 I51252.doc •14-201127424 ppm, 2000 ppm, 2500 ppm and 7800 ppm ° Figure 8C illustrates the hydrogen peroxide concentration of 2 〇 to 5 各 of each radial disk measured after about 60 minutes of cycling. The concentration of hydrogen peroxide in each of the radial disks 20 to 40 and 60 is about 150, 250, 600 and 1750 ppm, respectively. It can be seen that the reduction in the surface area of the radial disk has a large effect on neutralizing the hydrogen peroxide in the disinfectant. The smaller the surface area of the catalyst coated disc, the slower the neutralization effect. Figure 8D illustrates the measurement of the peroxygen gas concentration of each of the 20 to 40 and 60 radial disks after 120 minutes of cycling. The measurement results for each radial disk are approximately 8 〇 ppm '200 ppm, 500 ppm and 650 ppm °, respectively. Figure 8E shows The hydrogen peroxide values in the Clear Care's solution tested after 6 hours of radial disc 20 to 4 Torr and 6 Torr were reduced. The residual hydrogen peroxide content of the light-radiating disc 20 is less than 2 〇 ppm. This result indicates that when the Clear CareTM solution is used, the residual hydrogen peroxide concentration of the radial disk 2 is about the concentration of the prior art triangular disk 15. The residual hydrogen peroxide concentration of the radial disc with 2 arms removed was approximately 13 ppm. Therefore, the radial discs 20 and 3G will not increase the risk of burning and stinging associated with residual high concentration peroxide after the lens is cycled, and will maintain an effective system. However, the residual hydrogen peroxide concentration of the 4-arm radial disc is about b ppm, and the light-radial circle with a light-weight disc 2〇 half thickness is about 25 ppm. The use of a radial disc 4 or a radial disc 6〇 should not increase the risk of burning and sting associated with residual high concentrations of peroxide. The θ media 1 oxime neutralization rate is easily determined by the contact provided. Thus, any desired peroxygen can be achieved by increasing or decreasing the surface area of the catalyst-coated light-emitting disc used.
S 151252.doc 15 201127424 化氫中和速率。 备，照較佳及實例實施例描述本發明時，熟習此項技術 者將瞭解如以下請求蚊義之修飾、增補及刪減之變化係 屬於如藉由以下請求項定義之本發明之範圍。 【圖式簡單說明】 圖1係先前技術三角形觸媒盤之俯視圖。 圖2係根據本發明實例實施例之輪射狀觸媒圓盤之俯視 圖3係根據本發明實例實施例之削除2臂之輻射狀觸媒圓 盤之俯視圖。 圖4係根據苯發明實例實施例之削除4臂之輻射狀觸媒圓 盤之俯視圖。 圖5係根據本發明實例實施例之經切削之觸媒輻射狀圓 盤之俯視圖。 圖6係根據本發明實例實施例之輻射狀觸媒圓盤之透視 圖。 圖7係根據本發明實例實施例之改變5〇%高度之輻射狀 觸媒圓盤之透視圖。S 151252.doc 15 201127424 Hydrogen neutralization rate. The present invention will be described with reference to the preferred embodiments of the present invention, and it is understood that the modifications, additions, and deletions of the claims are intended to be within the scope of the invention as defined by the following claims. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a plan view of a prior art triangular catalyst disk. Fig. 2 is a plan view of a wheeled catalyst disk according to an exemplary embodiment of the present invention. Fig. 3 is a plan view of a radiation catalyst disk in which two arms are removed in accordance with an exemplary embodiment of the present invention. Figure 4 is a top plan view of a four-arm radial radiation catalytic disk according to an embodiment of the benzene invention. Figure 5 is a top plan view of a cut catalyst radial disk in accordance with an example embodiment of the present invention. Figure 6 is a perspective view of a radial catalyst disk in accordance with an example embodiment of the present invention. Figure 7 is a perspective view of a radial catalyst disk having a height change of 5% according to an embodiment of the present invention.
圖8A至E係表面積改變之輻射狀觸媒圓盤在aear careTM 溶液中循環20、30 ' 60 ' 120及360分鐘後，殘留過氧化氫 濃度之條形圖。 【主要元件符號說明】 15 先前技術三角盤 20 輻射狀觸媒圓盤 151252.doc •16- 201127424 30 削除2臂之輻射狀觸媒圓盤 40 削除4臂之輻射狀觸媒圓盤 50 輻射狀觸媒圓盤 60 高度改變50%之輻射狀觸媒圓盤 151252.doc - 17-Figures 8A through E are bar graphs of residual hydrogen peroxide concentration after a radial surface-changing radial catalyst disk is circulated for 20, 30 '60' for 120 and 360 minutes in aear careTM solution. [Main component symbol description] 15 Prior art triangular disk 20 Radial catalytic disk 151252.doc •16- 201127424 30 Radiation-type catalytic disk 40 with 2 arms removed Radial catalytic disk 50 with 4 arms removed Radial Catalytic disk 60 Radial catalytic disk with a height change of 50% 151252.doc - 17-