201124152 六、發明說明： 【發明所屬之技術領域】 本發明隸屬一種草藥萃取液之藥理用途。特定言 之’本發明揭示逋陳‘（了/⑽^)、雞蛋 反（PhmwHcicicutifolia)反澳洲茶樹（Mela〖eucaaltemif〇Ha) 複方或含該專之醫藥組成物於治療自體免疫失調疾病上 之用途，如用於治療乾癖。 【先前技術】201124152 VI. Description of the invention: [Technical field to which the invention pertains] The invention belongs to the pharmacological use of a herbal extract. Specifically, the present invention discloses a compound of 逋陈' (//10)^, PhmwHcicicutifolia anti-Australian tea tree (Mela eucaaltemif〇Ha) or a pharmaceutical composition containing the specific composition for treating autoimmune disorders. Use, such as for the treatment of cognac. [Prior Art]
按，乾癬又稱為銀屑病、牛皮癖，是一種自體免疫 失凋引發的慢性皮膚病，不具傳染性，並不會經由皮膚 接觸或其他管道傳染給別人。乾癖是皮膚的表皮代謝周 期異常縮短，不正常的快速增生所致，正常人約5〇〜6〇 天脫一次皮，乾癬表皮約7天就換一層，角質層常有角 化不全的現象，而有銀白的鱗屑。臨床上，可見角質增 =所引起的表皮增厚，異位性皮膚炎和正常皮膚有明顯 分界線的大小不一的紅色圓形斑塊，上方有數層銀白色 厚鱗屑，可以用指曱輕輕地抠下來，下面的皮膚會有一 點一點的小出血，並不會癢或是會微癢。 乾癬的病因尚未完全明瞭，目前只能夠控制，不容 ^根治。一般多認為是基因遺傳的疾病，和τ淋巴細 ^介導的發纽應有關，也可能是纽祕&問題，加 一些内在、外在誘因所引起。若是在遺傳因素背景下， 患乾癬’則子女有10%❺機會得此病；雙 去二ϊϊί’則30%子女可能罹患本病。發作時，患 =全身各躲都可μ贱乡且料皮屑和紅斑，最 位包括-頭皮、耳後、臉部、軀幹、肚臍周 ，、下月部、四肢（伸侧）、手肘、手掌、膝部、腳掌、 生殖器及指甲；甚至還會出現掉髮、關節炎等嚴重薇狀； 201124152 筚值常會偏高。輕微和中度乾癬的治療包括 固: ’ t局部潤滑乳霜、局部用藥、含有皮質類 、煤焦油或恩酚和謹慎的日光浴。若這些藥 Ιϊίί,ί夠的5益，可用紫外線(ofuv00)或合併使 二：抗乾癖藥，抗代謝產物或免疫抑制劑可用於 對一般治療不反應的麻煩或慢性病例。 也此’乾癖的治療用藥開發亦以前述的作用機制或 代5射特性進行。如美國專利案Να 4,210, 633(1980年7 月1日公佈）係採用一種含弗安奈德（flurandren〇lide)Press, cognac, also known as psoriasis, psoriasis, is a chronic skin disease caused by autoimmune infertility, is not contagious, and will not be transmitted to others through skin contact or other channels. Dry sputum is the abnormal shortening of the epidermal metabolic cycle of the skin, which is caused by abnormal rapid proliferation. The normal person takes about 5 〇 to 6 〇 days to take off the skin, and the dry epidermis is changed for about 7 days. The stratum corneum often has parakeratosis. And there are silvery scales. Clinically, it can be seen that the keratin is increased by the thickening of the epidermis, the atopic dermatitis and the normal skin have a clear dividing line of red circular plaques of different sizes, and there are several layers of silver-white thick scaly above, which can be lightly pointed Gently rubbing it down, the skin below will have a little bit of small bleeding, it will not itch or itchy. The cause of cognac is not fully understood. At present, it can only be controlled and cannot be cured. It is generally considered to be a genetically inherited disease, which is related to the tau lympho-mediated priming, and may also be caused by new and external causes. In the context of genetic factors, if you have cognac, then 10% of your children will have the chance to get the disease; if you go to 2ϊϊ, then 30% of the children may have the disease. At the time of the attack, the affected body can hide all the viscera and erythema, including the scalp, the back of the ear, the face, the trunk, the navel, the lower part of the moon, the extremities (extension), and the elbow. , palms, knees, soles, genitals and nails; even hair loss, arthritis and other serious verrucous; 201124152 筚 value will often be high. Treatments for mild and moderate dryness include: solidified creams, topical medications, corticoids, coal tar or phenol and cautious sunbathing. If these drugs are Ιϊίί, ί, 5 benefits, UV (ofuv00) or combined with 2: anti-dry drugs, anti-metabolites or immunosuppressants can be used in troublesome or chronic cases that do not respond to general treatment. The development of therapeutic drugs for dryness is also carried out by the aforementioned mechanism of action or by means of a 5-shot characteristic. For example, the US patent case Να 4,210, 633 (published on July 1, 1980) uses a flurandren〇lide
，膜巧成組合物來治療乾癖。膜形成成份為聚乙烯醇及 聚乙烯吡咯烷酮。而法國專利案N〇. 2539係有關以浸滲 類皮質激素之薄塑膠膜例如：乙烯聚合物，聚醯胺或聚 酯治療乾癬。又澳洲專利案No. 62189〇7係有關以一種 包含煤焦油及彈性載體材料之醫藥組合物來治療乾癬。 至於德國公告案Να 297329係有關一種治療局部乾癬之 醫藥組合物，其中包含丙烯酸酯及/或曱基丙烯酸酯之共 聚物作為活性劑。該組合物係呈均勻噴液施用，形成二 層彈性膜/另PCT申請案Να 92/04019係有關以6-甲 氧基-2-萘基乙酸局部治療乾癬之用途。pCT申請案 91/02538係有關治療哺乳動物角質化組織（例如：乾癖） 之組合物，其中包含一種膜形成蛋白質，可相容之還原 劑，反應性鋅鹽及至少一種膜形成聚合物。再者美國^ 利案No. 4, 826, 677(1989年5月2日公佈）係有關一種 治療乾癖之液體調配物，其含有蒽三醇（dith~ranol)勺 散在膜形成聚合物中。而歐洲專利申請書No. 223671 有關一種包含皮質類固醇與激動劑之抗乾癬組合 物。該組合物可施用形成膜。 、口 前述藥劑之治療結果通常需維持數個月之久方可達 到，但患者反而變得灰心及疏忽，因此無法達到治療效 201124152 果。 始終之未知成分，因此 於西醫所用之解剖及診斷以使不同 彿）的傳統方法ί（亦即將草藥在水中煮 能需要組合十種或多猶二樂。用於此種治療之處方可 不同之功能。、iiii療疾病之不同現象及症狀上有 活性，而㈣制人類疾病有可接受性臨床 效治療西方單—治療法二中幫=病樂的處方可有 及複:使用顯現反應之疾病為該等具有不明 ϊΐϊΐ 、病。特別的例子為敏感性_，盆中在 持，僅立中^其為终多R媒介物所弓1發及維 夕，、中數為已知。某些係關於抗原-抗體反庳。每 ί义被ϊ=ί經界定。單一治療劑如非類ί醇i 几ΐ人柰/、與特定發炎媒介物如***素相互 敏性濕疹無效。另一方面’皮質類固醇具有 ^種樂力作用及對濕療有效。因此，顯然嚴重之過敏 濕疹之治療需要對多種病理損害作同時性的攻擊，可处 關係至細胞内及體液内免疫過程。高皮質類固醇及上 免疫抑制劑具有對如此攻擊之所需活性之廣泛態 時二其用途因具毒性而受限制。已知治療濕疹用之^統 中藥似乎保有皮質類固醇及免疫抑制劑之必要活性而未 具毒性。 而 種選自草藥及其Pinyin均等物或以其Materia Medica名稱命名之草藥的中藥處方已被用以有效治療過 201124152 敏性濕疹及乾癬。用於過敏性濕疹孩童之如此藥方之臨 床效用被Sheehan等人敘述於BritishJournal of Dermatology (1992) 126 P.179-184 及用於成人者被 Sheehan 等人敘述於 The Lancet(1992)July 4th ρρ 13-17。製傷用於治療過敏性濕療及其他皮膚炎症之該等 10種草藥之萃取液的特別方法被敘述於GB-A-2254783。 事實上’已知上述10種草藥之煎煮液有效，含多數 草藥之複合藥方的使用是昂貴的，因此在能不危及有效 性或安全性的情況下，希望能簡化藥方。 【發明内容】 鲁 本發明揭示茵陳蒿（d、雞蛋 化 i Plumeria acutifolia)反無洲茶樹 Q Melaleuca alternifolia) 之複方或萃取液於治療乾癖上的藥學組成物。 發明簡述 一方面，本發明提供一種茵陳蒿（如化而此咕 77mm6)、雞蛋花（p/wwenvj沉故办如）及之複方，其能治 療乾癬。 另一方面，本發明提供一種治療乾癬之藥學組成 鲁 物’其包含則述之每陳萬（J你ciz/wY/izW·? 7%謂6 )、雞 蛋化（Plumeria acut(_a)、澳洲茶樹（MeIa!euca ahemif〇!ia) 複方或萃取液及可選擇地醫藥上可接受之賦形劑β 為使貴審查委員能進一步了解本發明的構成、特 徵及其他目的，以下乃舉本發明之較佳實施例，並配合 圖式詳細說明如后，同時讓熟悉該項技術領域者能夠具 體實施。 【實施方式】 本發明係種因陳蒿（ 201124152The membrane is a composition to treat dryness. The film forming components are polyvinyl alcohol and polyvinylpyrrolidone. The French patent case N〇. 2539 relates to the treatment of cognac with a thin plastic film impregnated with corticosteroids such as ethylene polymer, polyamine or polyester. Further, Australian Patent No. 62189〇7 relates to the treatment of cognac by a pharmaceutical composition comprising coal tar and an elastic carrier material. As for the German publication Να 297329, a pharmaceutical composition for treating topical dryness comprising a copolymer of acrylate and/or methacrylate as an active agent. The composition is applied as a uniform spray to form a two layer elastic film/other PCT application Να 92/04019 relates to the topical treatment of cognac with 6-methoxy-2-naphthylacetic acid. The pCT application 91/02538 is a composition for treating mammalian keratinized tissue (e.g., cognac) comprising a film forming protein, a compatible reducing agent, a reactive zinc salt, and at least one film forming polymer. Further, U.S. Patent No. 4,826,677 (published May 2, 1989) relates to a liquid formulation for treating dryness, which contains a dith-ranol scoop dispersed in a film-forming polymer. . European Patent Application No. 223671 relates to an anti-drying composition comprising a corticosteroid and an agonist. The composition can be applied to form a film. The treatment results of the above-mentioned drugs usually last for several months, but the patients become discouraged and negligent, so the therapeutic effect cannot be achieved. Always unknown ingredients, so the traditional methods used in Western medicine to anatomy and diagnosis to make different Buddhas) (ie, the herbs can be combined in water to cook ten or more kinds of music. For this treatment can be different Function, iiii treatment of different phenomena and symptoms of disease, and (4) human disease has acceptable clinical efficacy treatment of Western single treatment - two treatments = sick music prescriptions can be repeated: use the disease For these, there are unclear and sick cases. The special case is sensitivity _, the pot is held in the pot, only the middle is ^ it is the end of the R medium, the bow and the eve, the median is known. It is related to antigen-antibody 庳 庳 每 每 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一 单一In terms of 'corticosteroids', it has a lot of action and is effective for moist treatment. Therefore, it is obvious that the treatment of severe allergic eczema requires simultaneous attack on a variety of pathological damages, which can be related to intracellular and humoral immune processes. Corticosteroids and The immunosuppressive agent has a broad state of activity required for such an attack, and its use is limited by toxicity. It is known that the traditional Chinese medicine for treating eczema seems to retain the necessary activity of corticosteroids and immunosuppressants without Toxic. A prescription for Chinese medicine selected from herbs and its Pinyin equivalents or herbs named after its Materia Medica has been used to effectively treat 201124152 sensitizing eczema and dryness. It is used in children with allergic eczema. Clinical utility is described by Sheehan et al. in British Journal of Dermatology (1992) 126 P. 179-184 and used by adults by Sheehan et al. in The Lancet (1992) July 4th ρρ 13-17. Injury for the treatment of allergies A special method for extracting these 10 kinds of herbs for moist treatment and other skin inflammations is described in GB-A-2254783. In fact, it is known that the above 10 kinds of herbal decoctions are effective, and the combination of most herbs is used. It is expensive, so it is desirable to simplify the prescription without jeopardizing the effectiveness or safety. [Summary of the Invention] Luben's invention reveals the wormwood (d, egg i plume) A ria acutifolia) a pharmaceutical composition of a compound or extract of Q Melaleuca alternifolia) for the treatment of dryness. SUMMARY OF THE INVENTION In one aspect, the present invention provides a compound of Artemisia scoparia (such as 咕77mm6), Frangipani (p/wwenvj, such as the Office), and a combination thereof, which can treat dryness. In another aspect, the present invention provides a pharmaceutical composition for treating dryness, which includes the description of each of Chen Wan (J you ciz/wY/izW·? 7% said 6), eggification (Plumeria acut (_a), Australia Tea tree (MeIa!euca ahemif〇!ia) compound or extract and optionally pharmaceutically acceptable excipient β. To enable the reviewing committee to further understand the composition, features and other objects of the present invention, the following is the present invention. The preferred embodiment is described in detail with reference to the drawings, and can be implemented by those skilled in the art. [Embodiment] The present invention is based on Chen Art (201124152).
Thumb )、雞蛋花（)及澳洲茶樹 (Me/a/ewcc! a/ierm/o/zi)複方或萃取液及彼於乾癖上之 用途’隨附本發明具體實施例僅用於方便進行描述，並 非限制本發明，當可在不離開本發明之申請專利範圍 内，根據本發明之具體實施例的設計與需求而進行變化。Thumb), Plumeria () and Australian tea tree (Me/a/ewcc! a/ierm/o/zi) compound or extract and its use on a cognac 'with the specific embodiment of the invention is only for convenience The description is not intended to limit the invention, and may be varied in accordance with the design and needs of the specific embodiments of the invention, without departing from the scope of the invention.
本發明係一種利用天然本草植物組成之用以治療乾 癬的中草藥複方，該用以治療乾癬的中草藥複方包含有 西蘇％ ( Artemisia capillaris Thumb )、$隹蛋炎 Q piumeria cicuiifolia)及澳洲茶樹（Melaieuca altemifolia)等中萆藥組成 等中草藥所組成： ~ 其中茵陳蒿（如纪)佔複方總重 的5%〜21%，而雞蛋花佔複方總重 的65%〜90%，至於澳洲茶樹（她/此wcm/妙m/0^) ^複 方總重的4%〜16% ; 又本發明複方各成分的藥效、作用依據中醫典 “本草備要”記載為；其中 〃日 因陳高（Jr/em/s/a 77½^^ )，味苦、性平、微 寒。入脾、胃膽經。功效，就是清利濕熱，消退黃疫， 亦可用於濕瘡瘙癢、浸流黃水等症。 、一 而雞蛋花（尸flew所>/& )別稱緬振子、印卢+ f ιί角樹、番仔花、番花、大季花，屬夾竹桃科振 屬植物之一。其具有很強的抗真菌作用，對陽性和阶性 細菌以及結核都有明顯抑制效果。雞蛋花甙對陰性g 性細菌也有顯著抑制作用。其作用为清熱解毒，利濕、 止咳。用於預防中暑、腸炎、細菌性痢疾、消 潤肺解毒之功效等。 不良、 至於澳洲茶樹（崩a/eucaa/termfo/ia)具有消毒劑性 201124152 3許地2制許多普遍存在的致病細菌和黴菌。對 菌性、活絡人體***感染、癖等。具有很強的抗 體。 龙疾系統、激勵白血球防止細菌侵入人 再者本發明複方巾以雞蛋花 i Plumeria acutifo丨ia)爲 u 、几真菌與抑制細菌。另以澳洲茶樹（⑶ β =办诏）與茵陳蒿（加論·“巧―）為臣， 可抑濕瘡瘙疼、活絡人體免疾系統。 、同時諸藥能清利濕熱、抗菌仰菌，共同治療乾癖， Ψ 進而組構成-用以治療乾癬的中草藥複方。 、本^明中草藥複方可以典型的萃取、濃縮技術斜對 ^方生藥【原藥材】或各別成分生藥【原藥材】萃取、’ 濃縮後混合成藥粉而得，該藥粉亦可由生藥【原藥衬 直接碾碎成粉末而得，且包含其量為可有效治療、減 或抑制乾癬之中草藥複方，以及藥學上可選擇地醫藥上 可接受之賦形劑，而調製成經皮投遞之軟膏、乳霜、 劑或貼片等劑型。 藉此，可以理解到本發明為一創意極佳之創作，除 了有效解決習式者所面臨的問題’更大幅增進功效，且 在相同的技術領域中未見相同或近似的產品創作或公開 使用，同時具有功效的增進，故本發明已符合發明專利 有關「新穎性」與「進步性」的要件，乃依法提出申靖 發明專利。 【圖式簡單說明】 益 【主要元件符號說明】 無The invention relates to a Chinese herbal compound composed of natural herbal plants for treating cognac, and the Chinese herbal compound for treating cognac comprises Artemisia capillaris Thumb, Q piumeria cicuiifolia and Australian tea tree (Melaieuca) Altemifolia) and other Chinese herbal medicines such as Chinese herbal medicines: ~ Among them, Yinchenhao (Ruji) accounts for 5%~21% of the total weight of the compound, while the plumeria flower accounts for 65%~90% of the total weight of the compound. As for the Australian tea tree ( She/this wcm/miao m/0^) ^ 4% ~ 16% of the total weight of the compound; and the efficacy and effect of the ingredients of the compound of the present invention are recorded according to the "preparatives of the herbal medicine" of the Chinese medicine code; (Jr/em/s/a 771⁄2^^ ), bitter taste, flatness, slightly cold. Into the spleen, stomach and gallbladder. The effect is to clear the heat and dampness, to eliminate the yellow plague, and also to use it for itching, immersion and yellow water. One, the frangipani (corpse flew>>/&) is also known as the Burmese vibrator, Inlu + f ιί horn tree, sage flower, scented flower, big season flower, is one of the plants of the oleander family. It has a strong antifungal effect and has significant inhibitory effects on both positive and grading bacteria and tuberculosis. Egg buds also have a significant inhibitory effect on negative g-like bacteria. Its role is to clear away heat and detoxification, dampness, and cough. It is used to prevent heatstroke, enteritis, bacterial dysentery, and to eliminate lung and detoxification. Poor, as for the Australian tea tree (a/eucaa/termfo/ia) has disinfectant properties 201124152 3 Xu 2 2 many common pathogenic bacteria and mold. For bacteria, active vaginal infections, convulsions, etc. Has a strong antibody. Dragon disease system, stimulating white blood cells to prevent bacterial invasion. In addition, the compound towel of the present invention uses plum blossom i Plumeria acutifo丨ia) as u, several fungi and inhibit bacteria. In addition, the Australian tea tree ((3) β = 诏 诏) and Yin Chen worm (plus theory · "Qiao") as the minister, can suppress the sore and sore, and activate the human body disease-free system. At the same time, the various drugs can clear the damp heat, antibacterial Bacteria, co-therapy for cognac, Ψ and then group - a Chinese herbal compound for the treatment of cognac. This Chinese herbal compound can be extracted and concentrated in a typical way. It can be used as a raw material (original medicinal material) or a separate ingredient. 】 Extraction, 'concentrated and mixed into a powder, the powder can also be obtained from the crude drug directly pulverized into a powder, and the amount is effective to treat, reduce or inhibit the dry herbal Chinese herbal compound, and pharmaceutically acceptable Selecting a pharmaceutically acceptable excipient to prepare a dosage form such as a transdermally delivered ointment, cream, lotion or patch. It can be understood that the present invention is an excellent creation, in addition to effective treatment. The problem faced by the formulae 'is greatly enhanced the efficacy, and the same or similar product creation or public use is not seen in the same technical field, and the efficiency is improved, so the invention has met the invention patent. The requirements for "novelty" and "progressiveness" are based on the application of Shenjing invention patents. [Simple description of the diagram] Benefits [Main component symbol description] None