TW200940046A - Plastic ampule - Google Patents
Plastic ampule Download PDFInfo
- Publication number
- TW200940046A TW200940046A TW97110774A TW97110774A TW200940046A TW 200940046 A TW200940046 A TW 200940046A TW 97110774 A TW97110774 A TW 97110774A TW 97110774 A TW97110774 A TW 97110774A TW 200940046 A TW200940046 A TW 200940046A
- Authority
- TW
- Taiwan
- Prior art keywords
- layer
- plastic
- colored
- liquid
- thickness
- Prior art date
Links
- 229920003023 plastic Polymers 0.000 title claims abstract description 327
- 239000004033 plastic Substances 0.000 title claims abstract description 327
- 239000003708 ampul Substances 0.000 title claims abstract description 113
- 239000010410 layer Substances 0.000 claims abstract description 485
- 239000007788 liquid Substances 0.000 claims abstract description 200
- 239000003814 drug Substances 0.000 claims abstract description 99
- -1 cyclic olefin Chemical class 0.000 claims abstract description 93
- 239000012790 adhesive layer Substances 0.000 claims abstract description 26
- 230000009477 glass transition Effects 0.000 claims abstract description 11
- 239000000126 substance Substances 0.000 claims description 87
- 239000000049 pigment Substances 0.000 claims description 72
- 229920005989 resin Polymers 0.000 claims description 61
- 239000011347 resin Substances 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 47
- 229920001169 thermoplastic Polymers 0.000 claims description 46
- 239000006097 ultraviolet radiation absorber Substances 0.000 claims description 46
- 239000004416 thermosoftening plastic Substances 0.000 claims description 44
- 229920000573 polyethylene Polymers 0.000 claims description 32
- 239000004698 Polyethylene Substances 0.000 claims description 28
- 239000004743 Polypropylene Substances 0.000 claims description 27
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims description 26
- 229920001155 polypropylene Polymers 0.000 claims description 26
- 239000006096 absorbing agent Substances 0.000 claims description 24
- 238000000071 blow moulding Methods 0.000 claims description 23
- 238000004040 coloring Methods 0.000 claims description 22
- 238000011049 filling Methods 0.000 claims description 22
- 229920000098 polyolefin Polymers 0.000 claims description 20
- 238000003860 storage Methods 0.000 claims description 18
- 238000002834 transmittance Methods 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 13
- 229920001903 high density polyethylene Polymers 0.000 claims description 12
- 239000004700 high-density polyethylene Substances 0.000 claims description 12
- 229920001971 elastomer Polymers 0.000 claims description 11
- 239000000806 elastomer Substances 0.000 claims description 10
- 230000002093 peripheral effect Effects 0.000 claims description 10
- 239000002667 nucleating agent Substances 0.000 claims description 9
- 206010036790 Productive cough Diseases 0.000 claims description 8
- 210000003802 sputum Anatomy 0.000 claims description 8
- 208000024794 sputum Diseases 0.000 claims description 8
- 239000003086 colorant Substances 0.000 claims description 5
- 238000009833 condensation Methods 0.000 claims description 5
- 230000005494 condensation Effects 0.000 claims description 5
- 239000011859 microparticle Substances 0.000 claims description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- OWQPOVKKUWUEKE-UHFFFAOYSA-N 1,2,3-benzotriazine Chemical group N1=NN=CC2=CC=CC=C21 OWQPOVKKUWUEKE-UHFFFAOYSA-N 0.000 claims 1
- 229910052797 bismuth Inorganic materials 0.000 claims 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 abstract description 46
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 abstract description 32
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 238000010828 elution Methods 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 54
- 239000000047 product Substances 0.000 description 31
- 229920000642 polymer Polymers 0.000 description 29
- 238000007789 sealing Methods 0.000 description 25
- 239000000463 material Substances 0.000 description 24
- 239000000243 solution Substances 0.000 description 24
- 229940079593 drug Drugs 0.000 description 21
- 239000005977 Ethylene Substances 0.000 description 18
- 230000003014 reinforcing effect Effects 0.000 description 18
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 17
- 230000000694 effects Effects 0.000 description 15
- 239000012964 benzotriazole Substances 0.000 description 13
- 239000007864 aqueous solution Substances 0.000 description 12
- 229930195733 hydrocarbon Natural products 0.000 description 12
- 150000002430 hydrocarbons Chemical class 0.000 description 12
- 239000011265 semifinished product Substances 0.000 description 12
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 11
- 102000015347 COP1 Human genes 0.000 description 11
- 108060001826 COP1 Proteins 0.000 description 11
- 229910044991 metal oxide Inorganic materials 0.000 description 11
- 150000004706 metal oxides Chemical class 0.000 description 11
- 238000002156 mixing Methods 0.000 description 11
- 229950003837 ozagrel Drugs 0.000 description 11
- SHZKQBHERIJWAO-AATRIKPKSA-N ozagrel Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1CN1C=NC=C1 SHZKQBHERIJWAO-AATRIKPKSA-N 0.000 description 11
- 239000004215 Carbon black (E152) Substances 0.000 description 10
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 10
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 10
- 239000010419 fine particle Substances 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 238000007599 discharging Methods 0.000 description 9
- 229920001684 low density polyethylene Polymers 0.000 description 9
- 239000004702 low-density polyethylene Substances 0.000 description 9
- 238000007142 ring opening reaction Methods 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 239000002504 physiological saline solution Substances 0.000 description 8
- 238000009825 accumulation Methods 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229920002725 thermoplastic elastomer Polymers 0.000 description 7
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 150000004678 hydrides Chemical class 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 5
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 5
- 239000000654 additive Substances 0.000 description 5
- 150000001336 alkenes Chemical class 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 229920005673 polypropylene based resin Polymers 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000011787 zinc oxide Substances 0.000 description 5
- AFFLGGQVNFXPEV-UHFFFAOYSA-N 1-decene Chemical compound CCCCCCCCC=C AFFLGGQVNFXPEV-UHFFFAOYSA-N 0.000 description 4
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 4
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 240000007594 Oryza sativa Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000004840 adhesive resin Substances 0.000 description 4
- 229920006223 adhesive resin Polymers 0.000 description 4
- 101150059062 apln gene Proteins 0.000 description 4
- 210000003298 dental enamel Anatomy 0.000 description 4
- 230000006866 deterioration Effects 0.000 description 4
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 229920001519 homopolymer Polymers 0.000 description 4
- 239000011229 interlayer Substances 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 4
- 239000000779 smoke Substances 0.000 description 4
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 3
- 101100028962 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDR1 gene Proteins 0.000 description 3
- FHKPLLOSJHHKNU-INIZCTEOSA-N [(3S)-3-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]oxypyrrolidin-1-yl]-(oxan-4-yl)methanone Chemical compound C(C)N1N=CC(=C1C)C=1N(C2=NC=NC(=C2N=1)O[C@@H]1CN(CC1)C(=O)C1CCOCC1)C FHKPLLOSJHHKNU-INIZCTEOSA-N 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical class C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 3
- 238000005227 gel permeation chromatography Methods 0.000 description 3
- 229920001179 medium density polyethylene Polymers 0.000 description 3
- 239000004701 medium-density polyethylene Substances 0.000 description 3
- 239000000155 melt Substances 0.000 description 3
- 239000012968 metallocene catalyst Substances 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 229920005678 polyethylene based resin Polymers 0.000 description 3
- 229920013716 polyethylene resin Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000001052 yellow pigment Substances 0.000 description 3
- WSSSPWUEQFSQQG-UHFFFAOYSA-N 4-methyl-1-pentene Chemical compound CC(C)CC=C WSSSPWUEQFSQQG-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 2
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 244000088415 Raphanus sativus Species 0.000 description 2
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 2
- 229910052785 arsenic Inorganic materials 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- OCKPCBLVNKHBMX-UHFFFAOYSA-N butylbenzene Chemical compound CCCCC1=CC=CC=C1 OCKPCBLVNKHBMX-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 229920000092 linear low density polyethylene Polymers 0.000 description 2
- 239000004707 linear low-density polyethylene Substances 0.000 description 2
- 239000002159 nanocrystal Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000003359 percent control normalization Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 238000009751 slip forming Methods 0.000 description 2
- 229910021653 sulphate ion Inorganic materials 0.000 description 2
- 229910052715 tantalum Inorganic materials 0.000 description 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- PMJHHCWVYXUKFD-SNAWJCMRSA-N (E)-1,3-pentadiene Chemical compound C\C=C\C=C PMJHHCWVYXUKFD-SNAWJCMRSA-N 0.000 description 1
- YIWGJFPJRAEKMK-UHFFFAOYSA-N 1-(2H-benzotriazol-5-yl)-3-methyl-8-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Chemical compound CN1C(=O)N(c2ccc3n[nH]nc3c2)C2(CCN(CC2)C(=O)c2cnc(NCc3cccc(OC(F)(F)F)c3)nc2)C1=O YIWGJFPJRAEKMK-UHFFFAOYSA-N 0.000 description 1
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 1
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 1
- KWKAKUADMBZCLK-UHFFFAOYSA-N 1-octene Chemical compound CCCCCCC=C KWKAKUADMBZCLK-UHFFFAOYSA-N 0.000 description 1
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 description 1
- QQGRFMIMXPWKPM-UHFFFAOYSA-N 2,3,4-tributylphenol Chemical compound CCCCC1=CC=C(O)C(CCCC)=C1CCCC QQGRFMIMXPWKPM-UHFFFAOYSA-N 0.000 description 1
- BLDFSDCBQJUWFG-UHFFFAOYSA-N 2-(methylamino)-1,2-diphenylethanol Chemical compound C=1C=CC=CC=1C(NC)C(O)C1=CC=CC=C1 BLDFSDCBQJUWFG-UHFFFAOYSA-N 0.000 description 1
- NCIAZCLIFWUDPR-UHFFFAOYSA-N 2-butyl-3,4,5,6-tetramethylphenol Chemical compound CCCCC1=C(C)C(C)=C(C)C(C)=C1O NCIAZCLIFWUDPR-UHFFFAOYSA-N 0.000 description 1
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical group [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- NRCMAYZCPIVABH-UHFFFAOYSA-N Quinacridone Chemical compound N1C2=CC=CC=C2C(=O)C2=C1C=C1C(=O)C3=CC=CC=C3NC1=C2 NRCMAYZCPIVABH-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229910052769 Ytterbium Inorganic materials 0.000 description 1
- JAWMENYCRQKKJY-UHFFFAOYSA-N [3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-ylmethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]methanone Chemical compound N1N=NC=2CN(CCC=21)CC1=NOC2(C1)CCN(CC2)C(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F JAWMENYCRQKKJY-UHFFFAOYSA-N 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- RKFMOTBTFHXWCM-UHFFFAOYSA-M [AlH2]O Chemical compound [AlH2]O RKFMOTBTFHXWCM-UHFFFAOYSA-M 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 125000005577 anthracene group Chemical group 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229910000420 cerium oxide Inorganic materials 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- XOVJAYNMQDTIJD-UHFFFAOYSA-N cyclopentobarbital Chemical compound C1CC=CC1C1(CC=C)C(=O)NC(=O)NC1=O XOVJAYNMQDTIJD-UHFFFAOYSA-N 0.000 description 1
- 229950000178 cyclopentobarbital Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- CRHLEZORXKQUEI-UHFFFAOYSA-N dialuminum;cobalt(2+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Al+3].[Al+3].[Co+2].[Co+2] CRHLEZORXKQUEI-UHFFFAOYSA-N 0.000 description 1
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229920006242 ethylene acrylic acid copolymer Polymers 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- NYGZLYXAPMMJTE-UHFFFAOYSA-M metanil yellow Chemical group [Na+].[O-]S(=O)(=O)C1=CC=CC(N=NC=2C=CC(NC=3C=CC=CC=3)=CC=2)=C1 NYGZLYXAPMMJTE-UHFFFAOYSA-M 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 239000002991 molded plastic Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000010137 moulding (plastic) Methods 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000002440 power-compensation differential scanning calorimetry Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000011342 resin composition Substances 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- ZHROMWXOTYBIMF-UHFFFAOYSA-M sodium;1,3,7,9-tetratert-butyl-11-oxido-5h-benzo[d][1,3,2]benzodioxaphosphocine 11-oxide Chemical compound [Na+].C1C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2OP([O-])(=O)OC2=C1C=C(C(C)(C)C)C=C2C(C)(C)C ZHROMWXOTYBIMF-UHFFFAOYSA-M 0.000 description 1
- KFZUDNZQQCWGKF-UHFFFAOYSA-M sodium;4-methylbenzenesulfinate Chemical compound [Na+].CC1=CC=C(S([O-])=O)C=C1 KFZUDNZQQCWGKF-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 229920005992 thermoplastic resin Polymers 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
200940046 九、發明說明: 【發明所屬之技術領域】 本發明係關於一種塑膠安瓿、及由具有熱塑 !所形成之著色塑膠容器’詳細而言,係關於一種用於以 雄 '封狀態容納藥液之塑膠安瓶、及用以容納易於因紫 而產生分解、劣化之藥劑之著色塑膠容器。 、 【先前技術】 :年來,用於以密封狀態容納藥液之安飯,就對衝擊之 又、操作容易度及安全性之觀點 轉變為塑膠製安瓶。 係、自玻璃製文瓶 ^膠安瓶通常以如下方式構成,具備:用以容納藥液之 ^ 容納部’與該藥液容納部連通並向—側延伸之藥液排 ’及封閉該藥液排出筒部之一側端部之頂 出筒部之脆弱部(沿著圓周方向所形 ❹ |^πα. 2 '有猎由使上述藥液排出筒部之脆弱部 裂=如’扭斷或折裂)’而用以排出藥液之排出口。 可:聚膠安瓶係由聚乙婦或聚丙婦等醫藥上許 液之揮’近年來’就抑制容納於塑膠安親之藥 特別是屬於藥液之溶劑的水分之揮發· 藥液之濃縮),或抑制塑膠中所含之調 (共)聚合物。 —而…亦研究使用環狀稀烴系 具體而言’專利文獻1中 物為聚合物成由以環狀婦煙系化合 之⑽日材料所形成之塑膠安瓶,專利文獻 97110774 5 200940046 2中記載有一種最内層由含有聚環狀烯烴之樹脂所形成之 塑膠安瓿。 又,作為塑膠安瓿之製造方法,係如專利文獻2所記 -,,已知有連續實行藉由吹塑成形將安瓿成形之步驟、向 *女瓶内填充藥液之步驟,及密封安瓶之步驟的所謂吹塑· 填充.密封(bl0w/fin/seal,BFS)法,根據該BFS法, 可一體性形成塑膠安瓿,且可將藥液無菌性地容納於塑膠 ❹安瓶内並密封。 八又,此種塑膠製容器中,為了容納易於因紫外線而產生 分解、劣化之藥劑,而研究有對形成容器之塑膠材料賦予 遮光性,例如提案有於塑膠材料中調配顏料,或調配紫外 線吸收劑。 專利文獻3中記載有一種輸液袋用著色樹脂組合物,其 特徵在於,於100重量份之熱塑性樹脂中,調配02〜 3川重量份之色指數顏料黃95及/或色指數顏料黃147而 ❹成。 又專利文獻4提案有為了防止油性食品用容器因光線 而導致黏著劣化或提高内容物之保存性,對於以聚稀煙為 主體之内外層’介隔黏著劑樹脂層而將含有紫外線吸收劑 之乙烯-乙婦醇共聚物層設為中間層,並藉由所得之積層 ' 體來形成。 專利文獻1:日本專利特開平5_293159號公報 專利文獻2:國際申請案公開w〇2〇〇4/〇93775號公報 專利文獻3:曰本專利特開平^⑼⑷號公報 97110774 6 200940046 專利文獻4:日本專利特開平9—8657〇號公報 【發明内容】 (發明所欲解決之問題) Ί而’於藉由BFS法形成塑膠安瓶之情況下,環狀烯烴 * ” /、)聚合物之層係就防止安瓿之密閉性或成形性下降 之觀點而言,較佳為用作安瓶之最内層以外之層,又,就 防^顏料或紫外線吸收劑等添加劑溶出至藥液中之觀點 ❹而5,較佳為用作較調配有該等添加劑之層更内侧之層。 因此%狀烯烴系(共)聚合物之層自然而然地用作塑膠安 瓶之中間層。 2而,中間層由環狀烯烴系(共)聚合物之層所形成之塑 膠安瓿存在如下不良情況:例如,於開封安瓿之情況下, 於扭斷或折裂而產生之開口部,殘存通常稱作「毛刺」之 細樹脂片;或由於開口部變形或損壞,而難以自塑膠安瓿 排出藥液。 〇 又,於形成容器之塑膠材料中調配顏料之情況下,為了 充分遮蔽紫外區域之波長光,而必須調配大量顏料,故存 在如下不良情況:可見區域之波長光亦被遮蔽,從而難以 見到塑膠容器之内容物。 又,於塑膠材料中調配紫外線吸收劑,而充分遮蔽紫外 區域之波長光之情況下,亦存在如下擔憂:由於調配大量 紫外線吸收劑’因此成本上升之問題易變顯著,且產生紫 外線吸收劑向塑膠材料中分散之分散性下降,或紫外線吸 收劑自塑膠材料渗出(b 1 eed)之不良情況。 97110774 7 200940046 作為提高塑膝容器之遮光性之其他方法,一般認為有辦 加塑膠厚度,但於該情況下,存在如下擔憂:容器整體^ 度增加,於塑膠容器之操作性等方面產生障礙。特別是於 -塑膠容器為安親等相對較小型容器之情況下 •因厚度增加所造成之弊病。 貝見 =發明之目的在於提供—種塑膠安瓶,其可抑制 ❹ ;:安瓶之藥液之揮發·散失、或塑谬之調配劑溶出至藥 進Γ可抑制塑膠安瓶開封時產生毛刺、或開口部 之變形·損壞。 1 之其他目的在於提供—種著色塑膠容器 疋谷納易於因紫外線而產生分解、劣, 辨視容器内部。 j且易於 (解決問題之手段) 發等人為了達成上述目的而反覆努力研究,姓果 發現由多層塑膠所形成 九、、、。果 ❹ :層―用之環狀烯煙(共)聚二上玻 之: 2為特定範圍,則可解決上述課題,進: 遂完成本發明。 研九之、、、σ果’ 即’本發明之塑膠安瓿之特徵在於 液之藥液容納部;與上述藥液容納部連通^用二谷納樂 部;上述藥液排出筒部具備沿著:周出=, 弱部;上述藥液容納部、上述藥液 壁之脆 由多層塑踢形成,該多層塑膠係具備:含; 97110774 200940046 ::中〜:内之:狀㈣ 層。 ,之内層,及積層於上述中間層外側之外 出筒= :安瓶’由於形成藥液容納部、藥液排 聚合物,因1可之中間層含有環㈣烴系(共) 失、赤. 制各、,.内於塑膠安瓿之藥液之揮發.散 或J膠之調配劑溶出至藥液中。 且’根據本發明之塑膠安瓿 弱部開裂時之作業性Κ 辰排出^之脆 刺、或開口部之變形二可抑制塑膠安親開封時產生毛 與之ΓΓ及瓶上較佳係上述多層塑膠於上述中間層 備黏著層。θ Β 34中間層與上述外層之間,分別具 下’可提高上述中間層與上述内層之黏著性, 或上述申間層與上述外層之黏著性。 == 膠安瓶較佳係進而具備:由上述藥液裤出筒 :二上述脆弱部,自上述頂部侧之外周面連續而突起於2 而部外側之掰片,或自上述頂部之外表面連續 而犬起於上述頂部外側之掰片。 疋冥 奸於該If況下’將上述掰片握持而扭轉或變曲,藉此可 樂液排出筒部於該脆弱部扭斷或折裂 之操作變得容易。 线㈣ 本發明之塑膠安瓿較佳係進而具備增強 由上述藥液排出筒部之上述脆弱部,自上述藥液容納= 97110774 9 200940046 之外周面、及上述藥液容納部之外表面分料續 上述藥液排出筒部及上述藥液容納部之外側,且相 接。 目互連 於該情況下’藉由上料強片,可提高藥液容 液排出筒部間之剛性,故扭轉或f曲掰㈣, 藥: 容納部或藥液排出筒部之變形,x,可容易且準確地j ❹ 液排出筒部之脆弱部破裂。因此,可顯著提高塑 膠安瓿之作業性。 本發明之塑膠安瓿較佳係相對於上述藥液排出筒部之 上述多層塑膠之厚度,用於使上述脆弱部裂開所需之力為 〇. 65 N.m/mm 以下。 # 藉由將用於***上述藥液排出筒部之脆弱部所需之力 設定為上述範圍,可顯著提高用以使塑膠安瓿開封之作業 性。 ’、 本發明之塑膠安瓿較佳係上述多層塑膠之内層及外層 為 (i)含有密度為0.900〜0.940 g/cm3之高壓法聚乙 烯,或者 (ϋ )含有聚丙烯系樹脂。 於上述(i )之情況下,易於調節用於使上述脆弱部開裂 所需之力,且,扭斷或折裂上述脆弱部時之感觸良好。 於上述(11)之情況下’可提高塑膠安瓿之耐熱性。 又,於上述(ii )之情況下,較佳為上述聚丙烯系樹脂係 聚丙烯、聚丙烯彈性體與成核劑之混合物。 97110774 10 200940046 於該情況下’可提高上述多層塑膠之内層及外層之柔軟 性、透明性。 本發明之塑膠安瓿較佳係上述多層塑膠之中間層為由 - 混合樹脂形成’該混合樹脂含有:玻璃轉移溫度為60〜 .80°C之環狀烯烴系(共)聚合物,及密度為0. 900〜〇. 940 g/cm3之高壓法聚乙烯、或密度為0.940〜0.970 g/cm3之 高密度聚乙烯;上述混合樹脂中之密度為0.900〜0.940 g/cm3之高壓法聚乙烯、或密度為0.940〜0.970 g/cm3之 ^ 高密度聚乙浠的含有比例為30重量%以下。 於該情況下’易於調節用於使上述脆弱部開裂所需之 力’且,可提高中間層與内層及外層之黏著性。 本發明之塑膠安親較佳係上述多層塑膠之外層為 (ώ)含有著色劑,及/或 (诗)含有紫外線吸收劑。 於上述(iii)及(lv)之情況下,可對塑膠安瓿適當賦予遮 ❹光性。 於上述(iv )之情況下,較佳為上述紫外線吸收劑係苯并 ***系紫外線吸收劑。 又,於上述(iv)之情況下,較佳為上述多層塑膠之外層 中與紫外線吸收劑進一步一同含有金屬氧化物微粒子。 為了達成上述其他目的,本發明之著色塑膠容器之特徵 ·-在於,由熱塑性多層塑膠所形成,該熱塑性多層塑膠且 備:含有顏料及紫外線吸收劑之著色層;及直接或夾持/中 間層而積層於上述著色層之-侧表面之内層;上述著色層 97110774 11 200940046 之厚度T為50〜1000 “;上述著 比例取㈣、與上述著色層之厚 積 下述:训;上述著色層令之紫外線吸收劑之積含= υϋ)、與上34著色層之厚度Tun)之積υτ,於上述 1 SPTS 150..·⑴200940046 IX. INSTRUCTIONS: [Technical Field] The present invention relates to a plastic ampule, and a colored plastic container formed by having thermoplastics. In detail, it relates to a method for accommodating a drug in a male seal state. A plastic ampule for liquids, and a colored plastic container for containing a drug which is easily decomposed and deteriorated by purple. [Prior Art]: In the past years, the rice used to hold the liquid in a sealed state has been transformed into a plastic ampule from the viewpoint of impact, ease of operation, and safety. The ampoules are usually constructed in such a manner that the accommodating portion for accommodating the medicinal liquid is connected to the medicinal liquid accommodating portion and extends to the side, and the medicine is sealed. The fragile portion of the ejector portion of the side end portion of the liquid discharge cylinder portion (shaped along the circumferential direction) ^^α. 2 'has a stalk that causes the above-mentioned liquid medicine to discharge from the fragile portion of the tube portion = as 'twisted Or fracture] and used to discharge the discharge of the liquid. Can be: Polycollage ampoules are made by the use of liquid medicines such as polymethylene or polypropylene women in recent years to suppress the volatilization of water contained in plastics, especially the solvent of the liquid medicine. ), or inhibit the (co)polymer contained in the plastic. - and ... also studied the use of cyclically dilute hydrocarbons. Specifically, the material in Patent Document 1 is a plastic ampoule formed from a material of the (10) day of the combination of a ring-type flue-cured tobacco, Patent Document 97110774 5 200940046 2 A plastic ampule formed of a resin containing a polycyclic olefin is described as the innermost layer. Further, as a method of producing a plastic ampule, as described in Patent Document 2, it is known that a step of forming an ampoule by blow molding, a step of filling a liquid in a * bottle, and a sealed ampule are known. The so-called blow molding, filling and sealing (bl0w/fin/seal, BFS) method according to the BFS method can integrally form a plastic ampule, and the medicinal solution can be aseptically contained in a plastic enamel bottle and sealed. . In addition, in such a plastic container, in order to accommodate a drug which is easily decomposed and deteriorated by ultraviolet rays, it has been studied to impart a light-shielding property to a plastic material forming a container, for example, it is proposed to formulate a pigment in a plastic material, or to dispense ultraviolet light absorption. Agent. Patent Document 3 discloses a colored resin composition for an infusion bag, characterized in that 0 to 3 parts by weight of a color index pigment yellow 95 and/or a color index pigment yellow 147 are blended in 100 parts by weight of the thermoplastic resin. Yu Cheng. Further, in the case of the patent document 4, in order to prevent the oily food container from being deteriorated by light, or to improve the preservation of the contents, the inner and outer layers which are mainly composed of the concentrated smoke are interposed with the adhesive resin layer, and the ultraviolet absorber is contained. The ethylene-ethyl chant alcohol copolymer layer was set as an intermediate layer and formed by the resulting laminated body. Patent Document 1: Japanese Laid-Open Patent Publication No. Hei No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. Japanese Patent Laid-Open Publication No. Hei 9-86-57A SUMMARY OF THE INVENTION [Problems to be Solved by the Invention] In the case of forming a plastic ampule by the BFS method, a layer of a cyclic olefin*"/) polymer From the viewpoint of preventing the sealing property or the formability of the ampoule, it is preferable to use it as a layer other than the innermost layer of the ampoule, and to prevent the elution of an additive such as a pigment or an ultraviolet absorber into the liquid medicine. And 5 is preferably used as a layer which is more inner side of the layer to which the additives are formulated. Therefore, the layer of the olefin-based (co)polymer is naturally used as an intermediate layer of the plastic ampoules. A plastic ampule formed of a layer of a cyclic olefin-based (co)polymer has the following disadvantages: for example, in the case of opening an ampoule, the opening which is generated by twisting or breaking is often referred to as "burr". Fine resin ; Or due to damage or deformation of the openings, it is difficult to discharge drug solution from the plastic ampule. Further, in the case of formulating a pigment in a plastic material forming a container, in order to sufficiently shield the wavelength light in the ultraviolet region, a large amount of pigment must be formulated, so that there is a problem that the wavelength light in the visible region is also shielded, so that it is difficult to see The contents of the plastic container. Moreover, in the case where the ultraviolet absorber is blended in the plastic material and the wavelength light in the ultraviolet region is sufficiently shielded, there is also a concern that the problem of an increase in cost is apt to become remarkable due to the large amount of the ultraviolet absorber being dispensed, and the ultraviolet absorber is generated. The dispersion of the dispersion in the plastic material is degraded, or the ultraviolet absorber is exuded from the plastic material (b 1 eed). 97110774 7 200940046 As another method of improving the light-shielding property of a plastic knee container, it is generally considered that the thickness of the plastic is increased. However, in this case, there is a concern that the overall degree of the container increases, which causes an obstacle in the operability of the plastic container. Especially in the case of - the plastic container is a relatively small container such as a relative, etc. • The disadvantage caused by the increase in thickness. Bei Jian = The purpose of the invention is to provide a kind of plastic ampoules, which can inhibit sputum;: the volatilization and loss of the ampoules, or the dissolution of the plastic sputum to the medicinal sputum can inhibit the burrs of the plastic ampoules when they are opened Or deformation or damage of the opening. The other purpose of 1 is to provide a color-colored plastic container. The glutinous rice is easily decomposed and deteriorated by ultraviolet rays, and the inside of the container is observed. j is easy (the means to solve the problem), etc. In order to achieve the above objectives, the researcher repeatedly tried hard to study, and the surname was found to be formed by multi-layer plastics. ❹ ❹ : The layer-used cyclic olefin (common) condensed on the second: 2 is a specific range, the above problems can be solved, and: 遂 completed the present invention. The invention relates to a plastic ampule of the present invention characterized by a liquid chemical storage portion; a communication with the chemical liquid storage portion; a second valley portion; the chemical liquid discharge cylinder portion is provided along : Week out =, weak part; the above liquid medicine containing portion, the brittleness of the above liquid medicine wall is formed by multi-layer plastic kicking, and the multi-layer plastic system is provided with: 97110774 200940046: Medium to: inner: shape (four) layer. , the inner layer, and the laminating outside the outer layer of the above-mentioned intermediate layer = : An bottle 'Because the formation of the chemical liquid containing portion, the liquid medicine polymer, the intermediate layer containing the ring (4) hydrocarbon system (total) loss, red. The volatilization of the liquid in the plastic ampoule. The dispersing agent of the powder or J glue is dissolved into the liquid. And 'the brittle thorn of the working Κ 排出 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆 脆An adhesive layer is provided on the intermediate layer. Between the intermediate layer of θ Β 34 and the outer layer, respectively, the adhesion between the intermediate layer and the inner layer or the adhesion between the intermediate layer and the outer layer can be improved. == The plastic ampoules are further provided with: the above-mentioned liquid trousers discharge cylinder: two fragile portions, the cymbal continuous from the outer peripheral surface of the top side and protruding from the outer side of the second portion, or the outer surface from the top portion The sepals are continuous and the dog is on the outer side of the top. In the case of the present, the above-mentioned cymbal is held by the above-mentioned cymbal to be twisted or twisted, whereby the operation of the kelly discharge cylinder to be broken or broken at the fragile portion becomes easy. (4) The plastic ampule of the present invention is further provided with the fragile portion for enhancing the discharge of the chemical liquid from the cylindrical portion, and the outer surface of the chemical liquid containing the liquid chemical storage unit is 97110774 9 200940046, and the surface of the chemical liquid containing portion is continuously distributed. The chemical liquid discharge tube portion and the chemical liquid storage portion are outside and are in contact with each other. In this case, by the feeding of strong sheets, the rigidity between the discharge of the liquid of the liquid medicine can be increased, so that the twisting or f-curving (four), medicine: deformation of the receiving part or the discharge of the liquid medicine, x It is easy and accurate to break the fragile portion of the discharge portion of the liquid. Therefore, the workability of the plastic ampule can be remarkably improved. Preferably, the plastic ampule of the present invention is used for the thickness of the multilayer plastic of the discharge portion of the chemical liquid, and the force required to rupture the fragile portion is 〇65 N.m/mm or less. # By setting the force required to disintegrate the above-mentioned liquid medicine from the fragile portion of the cylindrical portion to the above range, the workability for unsealing the plastic ampule can be remarkably improved. The plastic ampule of the present invention is preferably such that the inner layer and the outer layer of the multilayered plastic are (i) high-pressure polyethylene having a density of 0.900 to 0.940 g/cm3, or (?) containing a polypropylene resin. In the case of the above (i), it is easy to adjust the force required for cracking the fragile portion, and the feeling of twisting or breaking the fragile portion is good. In the case of the above (11), the heat resistance of the plastic ampule can be improved. Further, in the case of the above (ii), a mixture of the polypropylene resin-based polypropylene, the polypropylene elastomer and the nucleating agent is preferred. 97110774 10 200940046 In this case, the softness and transparency of the inner layer and the outer layer of the multilayered plastic can be improved. The plastic ampule of the present invention is preferably such that the intermediate layer of the above-mentioned multilayer plastic is formed of a --mixed resin. The mixed resin contains a cyclic olefin-based (co)polymer having a glass transition temperature of 60 to 80 ° C, and a density of 0. 900〜〇. 940 g/cm3 of high-pressure polyethylene, or high-density polyethylene having a density of 0.940 to 0.970 g/cm3; high-pressure polyethylene having a density of 0.900 to 0.940 g/cm3 in the above mixed resin, Or the density of 0.940 to 0.970 g/cm3 of the high-density polyacetonitrile is 30% by weight or less. In this case, it is easy to adjust the force required for cracking the above-mentioned fragile portion, and the adhesion between the intermediate layer and the inner layer and the outer layer can be improved. Preferably, the plastic enamel of the present invention is such that the outer layer of the multi-layered plastic contains a coloring agent and/or contains a ultraviolet absorbing agent. In the case of (iii) and (lv) above, the plastic ampule may be appropriately provided with a light-blocking property. In the case of the above (iv), the ultraviolet absorber is preferably a benzotriazole-based ultraviolet absorber. Further, in the case of the above (iv), it is preferable that the outer layer of the multilayered plastic further contains metal oxide fine particles together with the ultraviolet absorber. In order to achieve the above other objects, the colored plastic container of the present invention is characterized in that it is formed of a thermoplastic multilayer plastic comprising: a coloring layer containing a pigment and an ultraviolet absorber; and a direct or clamping/intermediate layer And an inner layer laminated on the side surface of the colored layer; the thickness T of the colored layer 97110774 11 200940046 is 50 to 1000"; the above ratio (4), the thickness of the colored layer is as follows: training; The product of the ultraviolet absorber contains = υϋ), and the thickness Tτ of the thickness of the upper 34 colored layer, in the above 1 SPTS 150..·(1)
5SUTS 160... (2) 20< UTS 160.·. (3) 根據本發明之著色塑膠容器,可維持對容器内部之適度 辨視性,且可有效率地遮蔽紫外區域之波長光。因此,根 據本發明,可穩定容納易於因紫外線而產生分解、劣化之 藥劑。 本發明之著色塑膠容器較佳係上述著色層之另一侧表 面為上述熱塑性多層塑膠之外側表面。即,較佳係著色層 ❹為著色塑膠容器之外層。 又,於該情況下,更佳為將上述著色層中之紫外線吸收 劑的含有比例U(重量«除以上述著色層之厚度仅以約時 之商U/T滿足下述式(4)。 U/TS 0. 004··. (4) 藉由將著色層配置於熱塑性多層塑膠之外侧表面,即, ' 藉由將著色層設為熱塑性多層塑膠之最外層,可有效率地 發揮紫外線吸收劑之吸收紫外線的效果。又,於該情況 下,藉由將著色層中之紫外線吸收劑之含有比例設定為上 97110774 12 200940046 述範圍,可防止紫外線吸收劑自熱塑性多層塑膠表面滲 出。 八於本發明之著色塑膠容器中,較佳係上述顏料為偶氮縮 合系顏料,上述紫外線吸收劑為苯并***系紫外線吸收 劑。於該情況下,對紫外區域之光線的遮蔽效果變得良好。 又於本發明之著色塑膠容器中,較佳係上述熱塑性多 層塑膠之透射率對波長200〜380 nm之光線為5%以下, 且’對波長600 nm之光線為40%以上。 本發明之著色塑膠容器較佳係於上述著色層與上述内 層之間,具備環狀烯烴聚合物層。於該情況下,可防止著 色層:所含之顏料或紫外線吸收劑移動至内層侧或著色 ,膠容器之容納物,並可防止對容納於著色塑膠容器之藥 劑產生不良影響。 著色歸容諸佳係具備:形成為有底筒狀之 〇 二谷納樂液之藥液容納部;與藥液容納部之開口端連通 :二側延伸之藥液排出筒部;及封閉藥液排出筒部之- 部的著色塑膠安瓶…上述藥液容納部之執 生夕層塑膠之厚度為3〇〇〜15〇〇 ” ^,該情況下,較佳係著色塑膠容器(著色 藉由吹塑.填充.密封(BFS)法而形 女瓶) (發明效果) =本發明之歸錢,可抑制容納㈣㈣心 之揮發.散失、或塑膠之調配劑溶出 樂液 液排出筒部之脆弱部裂開時妊,且’將藥 作業性良好,可抑制塑膠安 97110774 200940046 瓿開封時產生毛刺、或開口部之變形·損壞。 办因,、,本發明之塑膠安瓿,適合用作例如於以密封狀態 合納藥液之安瓿,特別是適合用作藉由BFS法所製作之塑 膠安瓶。 本毛月之著色塑膠容器對容器内部具有適度辨視性,且 可有效率地遮蔽自容器外部向内部人射的紫外區域之光 線。因此’本發明之著色塑膠容器適合用於容納易於因紫 外線而產生分解、劣化之藥劑的用途。 【實施方式】 处以下’參照圖式,詳細說明本發明之塑膠安瓶之實施形 係表示本發明之塑膠安瓶之 固 ® ^ 1 , π a 口凡·^一 1她形態的前視 圖。又,相對於圖1所示之塑 圓,係俯視圖,係仰视圖視 所不之塑膠安瓶10,後視圖與前視圖一 /、圖1 圖與左側視圖一同表現。 見右側視 如圖1及圖2所示,塑膠安瓿 狀之用以容納藥液之藥液a 、 · >成為有底筒 開口端Ua連通並之向部1„1;與藥液容納部Η之 pa ^ ^ ^ 傾延伸之樂液排出筒部12 .另4+ 閉樂液排出筒部12之-側端部之頂部13 .单及封 12具備沿著圓周方向 ,杲液排出筒部 於藥液容納部U中^Λ壁之㈣部U° 7 ¢- 於〆告著藥液容納部U夕击 ^之長度方向上,於與底 MI之令心轴 相對之一側端部形成有開 97110774 200940046 口端lla’於該開口端lla之附近,具有徑自底部i6侧 向開口端11 a侧(一側)變小之肩部J 7。 、二圖4所示’藥液容納部η之剖面形狀係於俯 〇中視中形成為圓形狀’但藥液容納部u之上述剖面 形狀並不限定於此’例如亦可形成為橢圓狀。 J次參照圖1及圖2,藥液排出筒部12係以如下方式 、、 之中心軸15相同之輪*由、、▲丄 “之轴方向延伸。於藥液 藥液排出筒部12t,與藥液容納部】 對之側的端部)’形成有自上:侧相 液排出筒部12之頂部13。連續’並封鎖藥 藥液排出筒部12係例如在插 11内之藥液之注射器喷嘴的用以吸取藥液容納部 喷㈣之内徑,以便:二障况下’較佳為具有與上述 佳為於藥液容納部狀態固定該喷嘴,又,較 '之軸方向上具有充分之長。度。之間’於藥液排出筒部 樂液容納部U、藥液排出筒部 成為一體,並形成用以容納及密=頂部13相互連續 又,藥液排出筒部12係於液〜之封閉區域。 na至藥液排出筒部12 ”液谷納部11之開口端 具備沿著藥液排出筒部12之::部間之大致中間部分, 部14(參照圖5)。 °方向形成為薄壁之脆弱 猎此,握持藥液容納部u、 97110774 /、樂液排出筒部12之頂部 200940046 ? f曲’藉此可易於將脆弱部Η 扭斷或折裂、***。又’藉此可開封塑膠安錢。 二:此成為如下狀態··將藥液排出筒部Μ開口,於 此產生之開口部***省略圖示之注 =藥::納…之藥液。再二= ❹ ❹ ;下,…插人至藥液排二= 容納於藥液容納部11内之藥液。 f照圖5’藥液容納部1卜藥液排出筒部12及頂部13 由夕層塑膠形成,該多層塑膠具備:例° =:Γ環㈣烴系(共)聚合物之中二= 對於中間層18,而積層於塑膠安飯1〇之内側之 積層於塑膠安瓿1〇之外侧 胃, 與内層19間之黏著層21;及配二置於中間層18 間之黏著層22。 及配置於中間層18與外層20 =者,配置於中間層18與内層19 = 間之黏著層以她 才了’略該專黏者m,而相 膠安瓶1〇之内側表面與外侧表面之 ^層…於塑 配置内層19及外層2〇。 之兩側表面’分別直接 之作環為:於二1中間層18之、玻璃轉移溫度為6°〜_ <喂狀烯烴系(此) 人 一一例如可舉出:於乙;與二 聚物、乙稀與降贿系化合物之共聚物了環戊 97110774 16 200940046 之開環聚合物、多個環戊二烯衍生物 夕备外私τ梦+ 』 心開環共表物、該等 =Ό,玻璃轉移溫度為60〜8(rc範圍者。 想“ + 環狀烯烴系(共)聚合物可單 獨使用’亦可將2種以上混合佶用。π 了 早 又,至於環狀婦烴系 二二’於上述之中’較佳為可舉出··乙烯與降福烯 系化a物之共聚物之氢化物、ί種以上之環戍 之開環(共)聚合物之氫化物。 物5SUTS 160... (2) 20< UTS 160. (3) The colored plastic container according to the present invention maintains moderate visibility to the inside of the container and can efficiently shield wavelength light in the ultraviolet region. Therefore, according to the present invention, it is possible to stably accommodate a drug which is liable to be decomposed and deteriorated by ultraviolet rays. Preferably, the colored plastic container of the present invention is such that the other side surface of the colored layer is the outer side surface of the thermoplastic multilayer plastic. That is, it is preferred that the colored layer 之外 be an outer layer of the colored plastic container. Further, in this case, it is more preferable that the content ratio U of the ultraviolet absorber in the colored layer (the weight « divided by the thickness of the colored layer only satisfies the following formula (4) at a quotient U/T. U/TS 0. 004·. (4) By arranging the colored layer on the outer surface of the thermoplastic multilayer plastic, that is, by using the colored layer as the outermost layer of the thermoplastic multilayer plastic, UV absorption can be efficiently performed. The ultraviolet absorbing effect of the agent. Further, in this case, by setting the content ratio of the ultraviolet absorbing agent in the colored layer to the range of 97110774 12 200940046, the ultraviolet absorbing agent can be prevented from oozing out from the surface of the thermoplastic multilayer plastic. In the colored plastic container of the present invention, it is preferable that the pigment is an azo condensation pigment, and the ultraviolet absorber is a benzotriazole ultraviolet absorber. In this case, the shielding effect on the light in the ultraviolet region is good. Further, in the colored plastic container of the present invention, it is preferable that the transmittance of the thermoplastic multilayer plastic is 5% or less for light having a wavelength of 200 to 380 nm, and 40% of light having a wavelength of 600 nm. The colored plastic container of the present invention is preferably provided between the colored layer and the inner layer, and has a cyclic olefin polymer layer. In this case, the colored layer can be prevented from moving to the inner layer by the pigment or ultraviolet absorber contained therein. Side or coloring, the contents of the plastic container, and can prevent adverse effects on the medicine contained in the colored plastic container. The coloring is included in the series: the liquid medicine contained in the bottomed cylinder a communicating with the open end of the liquid medicine receiving portion: the liquid medicine discharging cylinder portion extending from the two sides; and the colored plastic ampoule of the closing portion of the liquid medicine discharging portion of the liquid medicine chamber; the plastic layer of the above liquid medicine containing portion The thickness is 3〇〇15〇〇” ^, in this case, it is preferably a colored plastic container (coloring by the blow molding, filling and sealing (BFS) method to form a female bottle) (invention effect) = return of the present invention Money can inhibit the containment of (4) (four) the volatilization of the heart. Loss, or the plastic compound dissolves the liquid liquid out of the fragile part of the tube when it is cracked, and 'the drug works well, can inhibit the plastics of 97110774 200940046 when the seal is opened glitch, Deformation and damage of the opening. The plastic ampule of the present invention is suitable for use as, for example, an ampoule which is filled in a sealed state, and is particularly suitable for use as a plastic ampoules produced by the BFS method. Maoyue's colored plastic container has moderate visibility to the inside of the container, and can effectively shield the light from the outside of the container to the ultraviolet area of the inside person. Therefore, the colored plastic container of the present invention is suitable for accommodating the ultraviolet light. The use of the plastic ampoules of the present invention is described in detail below with reference to the drawings, and the embodiment of the plastic ampoules of the present invention is shown in the following paragraphs. ^1 A front view of her form. Further, with respect to the plastic circle shown in Fig. 1, it is a plan view, and the plastic ampoules 10 are viewed from the bottom view, and the rear view is shown together with the front view/, Fig. 1 and the left side view. See the right side as shown in Fig. 1 and Fig. 2, the plastic ampule-shaped liquid medicine for containing the liquid medicine a, · > becomes the open end of the bottomed tube Ua and the direction of the body 1 1; and the liquid medicine receiving portion Pa pa pa ^ ^ ^ 延伸 之 乐 乐 discharged 筒 12 . 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 另 . . . . . . . . . . . . In the liquid chemical accommodating portion U, the (four) portion U° 7 ¢- is formed in the longitudinal direction of the medicinal liquid accommodating portion U, and is formed at one end side opposite to the mandrel of the bottom MI. There is a 9710774 200940046 mouth end 11a' near the open end 11a, and has a shoulder J 7 whose diameter is smaller from the side i6 lateral opening end 11 a side (one side). The cross-sectional shape of η is formed into a circular shape in the middle view of the plan view. However, the cross-sectional shape of the chemical liquid storage portion u is not limited thereto. For example, it may be formed in an elliptical shape. J. Referring to FIG. 1 and FIG. The discharge cylinder portion 12 is extended in the axial direction of the same wheel * by , ▲ 丄 in the following manner. The top 13 of the liquid phase discharge cylinder portion 12 from the upper side is formed in the chemical liquid discharge cylinder portion 12t and the end portion of the chemical liquid storage portion. Continuously and blocking the drug solution discharge cylinder portion 12 is, for example, a syringe nozzle of the liquid medicine in the insertion 11 for sucking the inner diameter of the liquid medicine receiving portion spray (4), so that it is preferable to have the above Preferably, the nozzle is fixed in the state of the chemical liquid containing portion, and is further sufficiently longer than the 'axis direction. degree. The liquid medicine discharge portion U and the liquid medicine discharge tube portion are integrated together, and are formed to be accommodated and sealed. The top portion 13 is continuous with each other, and the liquid medicine discharge cylinder portion 12 is tied to the closed portion of the liquid solution. . Na to the chemical liquid discharge cylinder portion 12" The open end of the liquid valley portion 11 is provided along the chemical liquid discharge cylinder portion 12: a substantially intermediate portion between the portions, and a portion 14 (see Fig. 5). The ° direction is formed into a thin wall. The fragile hunting, holding the liquid container accommodating portion u, 97110774 /, the top of the liquid discharging cylinder portion 12, 200940046, can easily break the fragile portion or break and split. Kaifeng plastic money. 2: This is the following state: • The drug solution is discharged from the opening of the tube, and the opening formed here is inserted into the drug solution of the drug: nanometer: 再 = ; Next, ... inserting into the liquid medicine row 2 = the liquid medicine contained in the chemical liquid containing portion 11. f. Figure 5 'The liquid medicine containing portion 1 the liquid discharging portion 12 and the top portion 13 are formed of a layer of plastic, which Multi-layer plastics have: Example ° =: anthracene ring (four) hydrocarbon system (co) polymer two = for the intermediate layer 18, and laminated on the inner side of the plastic ampoule 1 于 layer of plastic ampule 1 〇 outside the stomach, with the inner layer 19 adhesive layers 21; and an adhesive layer 22 disposed between the intermediate layers 18; and disposed in the intermediate layer 18 and the outer layer 20, disposed in the intermediate layer 18 The inner layer 19 = the adhesive layer between the two is the only one of the adhesive layer m, and the inner side surface and the outer side surface of the plastic ampoules are arranged in the inner layer 19 and the outer layer 2 塑. 'The direct use of the ring is: in the middle layer 18 of the two, the glass transfer temperature is 6 ° ~ _ < feed olefin system (this), for example, one can be mentioned: in B; with dimer, B A copolymer of a rare and a bribery compound, a cyclopental 97110774 16 200940046, a ring-opening polymer, a plurality of cyclopentadiene derivatives, a whitish outer τ dream + 』 a heart-opening ring, a surface, a Ό, a glass The transfer temperature is 60 to 8 (the range of rc. I think that "+ cyclic olefin system (co)polymer can be used alone" can also be used in combination of two or more types. π is early, as for the female hydrocarbon system 22 The above-mentioned 'preferably' is preferably a hydrogenated product of a copolymer of ethylene and a pentane-based a substance, or a hydrogenated product of a ring-opening (co)polymer of a ring of the above or more.
:形、間層18 a寺’藉由使用如上所述之環狀稀煙系 (共)聚合物,可使塑膠安瓿之強度或抗透水能力變得更良 好’且’可對塑膠安瓿賦予抗透氣能力。 又 再者作為上述環狀烯烴系(共)聚合物之具體例,可舉 出:例如具有以通式(A)表示之重複單位、及以通式(A,) 表不之重複單位之共聚物;例如具有以通式(B)表示之重 複單位之聚合物等。 [化1]: Shape, interlayer 18 a temple' By using the ring-shaped thin smoke (co) polymer as described above, the strength or water permeability of the plastic ampule can be made better 'and' can give resistance to plastic ampoules Breathability. Further, as a specific example of the above-mentioned cyclic olefin-based (co)polymer, for example, a copolymer having a repeating unit represented by the formula (A) and a repeating unit represented by the formula (A) can be mentioned. A compound such as a polymer having a repeating unit represented by the formula (B). [Chemical 1]
[化2][Chemical 2]
^ch2ch2·)^- 97110774 (B) 17 200940046 (式(A)、式(A,)及式⑻令,、Rl·、r2 3^ch2ch2·)^- 97110774 (B) 17 200940046 (Formula (A), Equation (A,) and Equation (8) Order, Rl·, r2 3
相同或不同’表示氫、烴殘基或極性基 R及R 可分別相互鍵結而形成環1、/ R與 同或不同,表示1以上之整數,η、 乂及2相 表示〇或1以上之整數。) y相同或不同, 作為烴殘基,例如可舉出烷基,The same or different 'represents hydrogen, a hydrocarbon residue or a polar group R and R may be bonded to each other to form a ring 1, / R is the same or different, and represents an integer of 1 or more, and η, 乂 and 2 phases represent 〇 or 1 or more. The integer. y is the same or different, and examples of the hydrocarbon residue include an alkyl group.
〜6之燒基,更佳為可舉出碳數為卜4為之^出碳數W 作為極性基,例如可舉出:㈣原子(例^ 氯原子、漠原子、埃原子等。)、酯、腈"比唆基等 上有以通式⑷及(A’)表示之重複單位:,係 =公知之開環聚合方法,使1種或2種以上之單:進= ς者或者,根據常法將如此獲得之開環聚合物進行氣化而 此種聚合物’例如可購冒公 製造之商品名「Z_0R(lH Ν有限公司 ❹ S_etiC Rubber L冊右商標)」、日本合成橡和a卿 「―冊商:等…公司製造之商品名 具有以通式(B)表示之重複單位之聚合物,係藉由公知 之方法’使作為單體的1種或2種以上之降福烯系單體鱼 乙烯進行加成共聚人而埋土 ^ 腹〆、 气π者,及/或,根據常法對其進行 風化而得者。 此種聚σ物’例如可講買三井化學股份有限公司製造之 商品名「舰(註冊商標)」、TIC0M G_製造之商品名 「T0PAS(註冊商標)」等。 陶名 97110774 18 200940046 具有以上述通式(A)、(A’)及(B)表示之重複單位之聚合 物中,其氫化物均係飽和聚合物,因此除了氣體遮蔽性或 水分遮蔽性以外,於耐熱性或透明性、進而穩定性方面較 ' 優異。 - 環狀烯烴系(共)聚合物之玻璃轉移溫度(Tg),係藉由 JIS K 7121,「塑膠之轉移溫度測定方法」所記載之功 率補償示差掃描熱析儀(功率補償Dsc)所測定的中間點玻 ❿璃轉移溫度(Tmg);且用於形成中間層18之環狀烯烴系(共) 聚合物之Tg’如上所述設定為60〜8(^c,較佳為65〜8〇它 之範圍。 若環狀烯烴系(共)聚合物之Tg超過8(rc,則產生如下 不良情況:於因脆弱部14之開裂而產生之開口部上,殘 存有稱作「毛刺」之細樹脂片。又,若環狀烯烴系(共) 聚合物之Tg超過8(TC,則藉由扭斷或折裂而***脆弱部 14所需之力增加,難以使塑膠安瓿丨〇開封。相反地,若 ❿環狀烯烴系(共)聚合物之Tg低於60°C,則中間層18所 要求之水蒸氣阻隔性、或防止樹脂添加物等移動至内容液 中之效果下降,而無法達成本發明所期望之目的。 環狀烯烴系(共)聚合物之熔融流動速率(melt f 1〇w rate,MFR)並無特別限定,就塑膠安瓿之成形性或力學特 性等觀點而s,較佳為4〜30 g/l〇分鐘(26〇。〇)。 環狀烯烴系(共)聚合物之分子量並無特別限定,數量平 均分子量<Mn>較佳為1萬〜1〇萬,更佳為2萬〜5萬。再 者,平均分子量係例如藉由以環己烷為溶劑之凝膠滲透層 97110774 19 200940046 析法(GPC)分析,作為苯乙烯換算值而求得。 中間層18例如可僅由玻璃轉移溫度(Tg)為60〜80°C之 環狀烯烴系(共)聚合物形成,亦可例如由包含Tg為60〜 80°C之環狀烯烴系(共)聚合物及聚乙烯之混合樹脂形成。 作為此種混合樹脂,較佳為例如可舉出:包含Tg為60 〜80°C之環狀烯烴系(共)聚合物、及密度為〇. 900〜〇. 940 g/cm3(更佳為密度為0.920〜0.930 g/cm3)之高壓法聚乙 烯或密度為0.940〜0.970 g/cm3之高密度聚乙烯的混合 樹脂。 高壓法聚乙烯係藉由高壓法所製造之支鏈狀聚乙烯。另 一方面,尚密度聚乙烯係藉由中低壓法所製造之直鏈狀聚 乙烯,且該高密度聚乙烯例如可為乙烯之均聚物,例如亦 可為乙稀、與丙烯、丁烯—卜戊稀]、己稀_卜4_甲基戊 烯-1、辛烯-1、癸烯-1等α _烯烴類之共聚物。 ❹ 藉由使用上述混合樹脂作為形成中間層18之樹脂,可 易於設定藉由扭斷或折裂而使脆弱部14裂開所需之力, 又’可提高中間層18與鄰接於該中間層18之内層^或 外層2 0之黏著性。進而,力料 物、μ# π 在對上述%狀烯烴系(共)聚合 物混合上述咼密度聚乙烯之愔 之透明性,故較佳。^下,可充分維持混合樹脂 於上述混合樹脂中,齋择也Λ 〇. 920^ 0. 930 ;/cm3^ 為0.940〜0.970 g/cm3之古〜间壓法聚乙烯、或密度 為上述混合樹輕體之3(^、_4聚乙烯之含有比例,較佳 3〇重量%以下,更佳為5〜30重量 97110774 20 200940046 %/特佳4 5〜25重量%。若上述混合樹脂中之上述高壓法 ^婦或上述同雄、度聚乙烯之混合比例超過上述範圍,則 存在環狀烯烴系(共)聚合物所要求之上述性能變得不充 分之擔憂。 ' 作為形成内層19及外層20之樹脂,例如可舉出聚埽烴。 a =為聚烯丸並無特別限定,例如可舉出習知醫療用塑 膠了器可使用之各種聚烯烴,其中,較佳為可舉出聚乙稀 ⑩系樹脂或聚丙烯系樹脂。而且,於重視醫療用塑膠容器之 耐熱性之情況下,可較佳地使用聚丙烯系樹脂。 作為聚乙烯系樹脂’例如可舉出:高壓法(支鏈狀)低密 度聚乙烯(HP-LDPE)、直鏈狀低密度聚乙烯(LLDpE)、中密 度聚乙烯⑽PE)、高密度聚乙烯⑽pE)等均聚物,或聚乙 烯系聚物。作為聚乙烯系共聚物中之乙烯以外之共單 體’可舉出與上述相同之α_烯烴類。又,該聚乙烯系共 聚物中6稀以外之共單體之含有比例,較佳為莫耳% ❹以下,更佳為3〜20莫耳%。 、 ^ 稀系樹爿曰之性狀並無特別限定,就與含有環狀烯烴 系(八)聚5物之中間層丨8之成形性、藉由扭斷或折裂而 使脆弱部14裂開所需之力之設定容易度、及塑膠安瓿之 力學=性等觀點而言,較佳為選擇相對較低密度之聚乙稀 系樹脂,具體而言係密度為0.900〜〇.940 g/cm、較佳為 〇· 920〜〇· 930 g/cm3之範圍的高壓法聚乙 ㈣乙稀,可舉出與作為形成中間層18之:二: 者相同者。 97110774 21 200940046 聚乙烯系樹脂之熔融流動速率⑽)並無特別限定,就 與含有環狀烯烴系⑷聚合物之中間層18之成形性 塑膠安訊之力學特性等觀點而言,較佳為Q 2〜 分鐘(190°C )。 另-方面,作為聚丙烯系樹脂’例如可舉出:等規聚丙 婦、間規聚丙婦等結晶性均聚物,或含有少量共單體之結 晶性共聚物。 ° ❹ 作為上述結晶性共聚物中之丙烯以外之共單體,例如可 :出:乙烯、丁烯'卜戊烯-卜己烯+ 4-曱基戊烯-卜 辛稀小癸烤一1等^婦烴類。又,上述結晶性共聚物中 之丙婦以外之共單體之含有比例,較佳為30莫耳%以下, 更佳為、2〜30莫耳%,特佳為3〜25莫耳%。 為了對上述聚丙烯系樹脂賦予柔軟性,可較佳地使 Γο:::生體。特別是使用二茂金屬觸媒所製造之密度 . .870 g/cm3、玻璃轉移溫度(Tg)為-1(TC以下 = :性體’因兼具耐熱性、透明性及柔軟性,故較 二有If八㈣ΐ種聚丙烯彈性體,例如可購買三井化學股 刀有限Α司製造之商品名「ΝΟΤΙΟ」。 嫌其他聚丙婦彈性體,例如可舉出低結晶性聚丙 「T^MER〔^ % ’三井化學股份有限公司製造之商品名 夕卜声20= 十冊商標)」X系列等)°相對於形成内層19或 為^0 40^量’該等聚丙稀彈性體之調配比例較佳 為1 0〜40重量%。 聚丙稀糸樹脂之炫融流動速率(_)並無特別限定,就 97110774 22 200940046 與含有環狀烯烴系(共)聚合物之中間層18之成形性、 塑膠安瓿之力學特性等觀點而言,較佳為〇 2〜2〇 \More preferably, the carbon number is 6%, and the carbon number is W. The polar number is, for example, a (four) atom (for example, a chlorine atom, a desert atom, an argon atom, etc.), The ester, nitrile " fluorenyl group and the like have repeating units represented by the general formulae (4) and (A'): a system of known open-loop polymerization, one or two or more kinds of single: The gasification of the ring-opening polymer thus obtained is carried out according to the usual method, and the polymer can be purchased, for example, under the trade name "Z_0R (lH Ν Co., Ltd. ❹ S_etiC Rubber L)." And "a", "a brand of a product, which has a repeating unit of the formula (B), which is a product of the company's product, which is a method of a known method, which is used to reduce one or more kinds of monomers as a monomer. The olefinic monomeric fish, ethylene, is added and copolymerized, and the soil is buried, the belly sputum, the gas π, and/or it is weathered according to the conventional method. The poly sigma can be bought, for example, by Mitsui Chemicals. The product name "ship (registered trademark)" manufactured by the company, and the trade name "T0PAS (registered trademark) manufactured by TIC0M G_) Wait. Tao Ming 97110774 18 200940046 Among the polymers having the repeating units represented by the above formulas (A), (A') and (B), the hydrides are all saturated polymers, and therefore, in addition to gas shielding properties or moisture shielding properties It is superior in heat resistance, transparency, and stability. - The glass transition temperature (Tg) of the cyclic olefin-based (co)polymer is determined by a power-compensated differential scanning calorimeter (power compensation Dsc) described in JIS K 7121, "Method for Measuring Plastic Transfer Temperature" The intermediate point glass transition temperature (Tmg); and the Tg' of the cyclic olefin system (co)polymer used to form the intermediate layer 18 is set to 60 to 8 (^c, preferably 65 to 8) as described above. In the case where the Tg of the cyclic olefin-based (co)polymer exceeds 8 (rc), there is a problem in that an opening called "burr" remains on the opening due to the cracking of the fragile portion 14. Further, if the Tg of the cyclic olefin-based (co)polymer exceeds 8 (TC), the force required to break the fragile portion 14 by twisting or breaking increases, and it is difficult to open the plastic ampule. On the other hand, when the Tg of the cyclic olefin-based (co)polymer is less than 60 ° C, the water vapor barrier property required for the intermediate layer 18 or the effect of preventing the resin additive or the like from moving to the content liquid is lowered. The desired object of the present invention cannot be achieved. The melting of a cyclic olefin system (co)polymer The melt flow rate (melt f 1〇w rate, MFR) is not particularly limited, and is preferably from 4 to 30 g/l 〇 minutes (26 〇. 〇) in terms of the formability or mechanical properties of the plastic ampule. The molecular weight of the cyclic olefin-based (co)polymer is not particularly limited, and the number average molecular weight <Mn> is preferably 10,000 to 10,000, more preferably 20,000 to 50,000. Further, the average molecular weight is, for example, It is obtained by a gel permeation layer of 9710774 19 200940046 by a method of analysis (GPC) using cyclohexane as a solvent, and is obtained as a styrene equivalent value. The intermediate layer 18 can be, for example, only a glass transition temperature (Tg) of 60 to 80 ° C. The cyclic olefin-based (co)polymer is formed, and may be formed, for example, of a cyclic olefin-based (co)polymer having a Tg of 60 to 80 ° C and a mixed resin of polyethylene. For example, a cyclic olefin-based (co)polymer having a Tg of 60 to 80 ° C and a density of 〇 900 to 940 g/cm 3 (more preferably a density of 0.920 to 0.930 g/cm 3 ) may be mentioned. High-pressure polyethylene or a mixed resin of high-density polyethylene having a density of 0.940 to 0.970 g/cm3. a branched polyethylene produced by a high pressure method. On the other hand, a still-density polyethylene is a linear polyethylene produced by a medium-low pressure method, and the high-density polyethylene may be, for example, a homopolymer of ethylene. For example, it may be a copolymer of ethylene olefin, propylene, butene-p-pentylene, hexamethylene-4-pentene-1, octene-1, decene-1 and the like.藉 By using the above-mentioned mixed resin as the resin forming the intermediate layer 18, the force required to break the fragile portion 14 by twisting or breaking can be easily set, and the intermediate layer 18 can be raised and adjacent to the intermediate layer. The adhesion of the inner layer or the outer layer 20 of the 18 layer. Further, it is preferable that the force material and μ# π are transparent to the above-mentioned fluorene-density polyethylene in the above-mentioned % olefin-based (co)polymer. ^, can fully maintain the mixed resin in the above mixed resin, 斋 Λ Λ 920 ^ 0. 930 ; / cm 3 ^ is 0.940 ~ 0.970 g / cm 3 of the ancient ~ inter-pressure polyethylene, or the density of the above mixture The light weight of the tree 3 (^, _4 polyethylene content ratio, preferably 3 〇 wt% or less, more preferably 5 to 30 weight 97110774 20 200940046% / particularly good 4 5 to 25 wt%. If the above mixed resin When the mixing ratio of the above-mentioned high-pressure method or the above-mentioned male and polyethylene is more than the above range, the above-mentioned performance required for the cyclic olefin-based (co)polymer may be insufficient. 'As the inner layer 19 and the outer layer are formed. For example, a polyalkylene pellet is not particularly limited, and examples thereof include various polyolefins which can be used in a conventional medical plasticizer. Among them, polycondensation is preferred. Ethylene-based resin or polypropylene-based resin. When a heat-resistant plastic container for medical use is used, a polypropylene-based resin can be preferably used. Examples of the polyethylene-based resin include a high-pressure method ( Branched) low density polyethylene (HP-LDPE), straight Low-density polyethylene (LLDPE), medium density polyethylene ⑽PE), high density polyethylene ⑽pE) homopolymers, or polyethylene-based polymers. Examples of the co-monomer other than ethylene in the polyethylene-based copolymer include the same α-olefins as described above. Further, the content ratio of the comonomer other than 6 dilute in the polyethylene-based copolymer is preferably not more than mol%, more preferably 3 to 20 mol%. The nature of the rare tree mites is not particularly limited, and the fragile portion 14 is cleaved by the moldability of the intermediate layer 含有8 containing the cyclic olefin system (8) poly 5 material, by twisting or breaking. From the viewpoints of ease of setting of the required force and mechanical properties of the plastic ampule, it is preferred to select a relatively low density polyethylene resin, specifically, a density of 0.900 to 940.940 g/cm. Preferably, the high-pressure method polyethylene (tetra)ethylene in the range of 930 〇 920 〇 930 g/cm 3 is the same as the two layers forming the intermediate layer 18: two. 97110774 21 200940046 The melt flow rate (10) of the polyethylene resin is not particularly limited, and is preferably Q from the viewpoint of the mechanical properties of the molded plastic of the intermediate layer 18 containing the cyclic olefin system (4) polymer. 2 to minutes (190 ° C). In addition, examples of the polypropylene resin include, for example, a crystalline homopolymer such as an isotactic polypropylene or a syndiotactic polypropylene, or a crystalline copolymer containing a small amount of a comonomer. ° ❹ As a comonomer other than propylene in the above crystalline copolymer, for example, ethylene: butene's pentene-p-hexene + 4-decylpentene-b-sin Wait for women's hydrocarbons. Further, the content ratio of the comonomer other than the propylene compound in the crystalline copolymer is preferably 30 mol% or less, more preferably 2 to 30 mol%, particularly preferably 3 to 25 mol%. In order to impart flexibility to the above polypropylene-based resin, it is preferable to use Γο::: a raw body. In particular, the density produced by using a metallocene catalyst is .870 g/cm3, and the glass transition temperature (Tg) is -1 (TC below =: the physical body' has both heat resistance, transparency and flexibility, so (2) If there is a polypropylene elastomer of the VIII (4) type, for example, the trade name "ΝΟΤΙΟ" manufactured by Mitsui Chemicals Co., Ltd. can be purchased. For other polypropylene elastomers, for example, low crystal polyacryl "T^MER[^ % 'Mitui Chemical Co., Ltd. manufactures the product name 夕卜声20=10 copies of the trademark) "X series, etc.) ° Relative to the formation of the inner layer 19 or the amount of the above-mentioned polypropylene elastomer is preferably adjusted. It is 1 0 to 40% by weight. The swell flow rate (_) of the polypropylene resin is not particularly limited. From the viewpoints of the formability of the intermediate layer 18 containing the cyclic olefin-based (co)polymer and the mechanical properties of the plastic ampule, Preferably 〇2~2〇 \
分鐘(230°C)« g U 内層19及外層20例如可僅由聚乙婦系樹脂或聚 樹脂形成,例如亦可由聚丙烯、聚丙烯彈性體與成核劑: 混合物形成。於該情況下,可提高内層19或外層2〇 明性。 ❹ 作為成核劑,例如可舉出·· 2,2,-亞甲雙(4,6_二_第三 丁基苯基)磷酸鈉(NA-11)、雙[2,2_亞甲基_雙(4,6_二: 第三丁基苯基)磷酸]經基紹(NA-21)等鱗酸系成核劑等: 再者,内層19或外層20均不限定於單一層,例如可 述樹脂中所選擇的互不相同之樹脂所形成之層的 積層體。 ❹ 於T間層18與内層19之層間、及中間層18與外 曰 之層間,視需要可分別設置黏著層21、22。 =$成黏著層2卜22之樹脂,例如可舉出:LLDpE(特 St用二茂金屬觸媒等單點觸媒而聚合者)、聚乙稀系 該等之混合樹脂。x,黏著層形成用樹脂中,除 了^外’例如亦可舉出作為黏著用樹脂而公知的不飽 酯共聚物等。 碲丙焊U物、乙烯-乙酸乙烯 門:二V卜22之厚度並無特別限定’於所鄰接之層(中 與内層19、中間層18與外層20)之黏著中為充分 -可。具體而言’相對於所鄰接之層之厚度,較佳為 97110774 23 200940046 2〜10%左右。 等進而’於外層20中例如可調配著色劑、紫外線吸收劑 著色劑係為了降低塑膠安 安瓿之藥液產生光劣彳卜,七^之透先性、防止容納於塑膠 碉配八 $為了對塑膠安瓿賦予創作性而 可舉出:例如C.L顏料黃95、C.I.顏 "7、C.I.顏料黃 180、CI.顏 Ο ==22°、“顏料㈣等紅 =1=顏料。該等顏料可單獨❹,亦 勝配量’係根據形成外層20之樹脂厚度、塑 光性程度等而適當設定即可,並無特別 歹形成外層20之樹脂中,較佳為0.01〜0.4重 重% 0 紫外線吸㈣係為了降低㈣絲之料線透過性、防 止容納於塑膝安瓶之藥液因紫外線而產生之劣化而調配 之成分’具體而言’例如可舉出:2_(2,-羥基_5,一甲基苯 酚)苯并***(汽巴精化(CibaSpecialty股份 有限公司製造之商品名「TINUVIN(註冊商標)p」)、2_(2,一 羥基3,5雙(甲基苄基)苯酚)苯并***(汽巴精化股份 有限么司製造之商品名「(註冊商標)234」)、 2-/2’-羥基-3’-第三丁基_5’_曱基苯酚)_5—氣苯并*** (>%巴精化股份有限公司製造之商品名「TINUVIN(註冊商 標)326」)、2-(2,-羥基_3’,5’_二-第三丁基苯酚)—5_氯 97110774 24 200940046 苯并二唑(汽巴精化股份有限公司製 「Τί_ίΝ(註冊商標)327」)、2-(2, 一經基—3,,5商品名 三戊基苯酚)苯并***(汽巴精化股份有限公 ; 品名「τ副簡註冊商標)328」)、2_(2,m =之商 基丁基苯齡)苯并三峻(汽巴精化股份有限四: 品名「Π_ΙΝ(註冊商標)329」 t之商 收劑等。 T生糸盏外線吸 eThe minute (230 ° C) « g U inner layer 19 and the outer layer 20 can be formed, for example, only from a polyethylene-based resin or a poly resin, for example, a polypropylene, a polypropylene elastomer, and a nucleating agent: mixture. In this case, the visibility of the inner layer 19 or the outer layer 2 can be improved. ❹ As a nucleating agent, for example, 2,2,-methylenebis(4,6-di-t-butylphenyl)phosphate (NA-11), bis[2,2_methylene Base_bis(4,6_di: tert-butylphenyl)phosphoric acid] is a sulphate-based nucleating agent such as basal (NA-21): Further, the inner layer 19 or the outer layer 20 is not limited to a single layer. For example, a laminate of layers formed of mutually different resins selected from the resins may be mentioned. Between the layers of the T-interlayer 18 and the inner layer 19, and between the layers of the intermediate layer 18 and the outer layer, the adhesive layers 21 and 22 may be separately provided as needed. The resin of the adhesive layer 2, 22, for example, a mixed resin such as LLDpE (a polymer which is polymerized by a single catalyst such as a metallocene catalyst) or a polyethylene. In the resin for forming an adhesive layer, for example, an unsaturated ester copolymer or the like which is known as an adhesive resin may be mentioned. The U-material and the ethylene-vinyl acetate door are not particularly limited to the thickness of the adjacent layer (the middle layer 19, the intermediate layer 18 and the outer layer 20). Specifically, it is preferably about 97110774 23 200940046 2 to 10% with respect to the thickness of the adjacent layer. And so on, in the outer layer 20, for example, a coloring agent can be adjusted, and a coloring agent for the ultraviolet absorbing agent is used to reduce the quality of the plastic ampules of the plastic, and the transparency of the sputum is prevented. Plastic ampoules give creativity: for example, CL Pigment Yellow 95, CI Yan " 7, CI Pigment Yellow 180, CI. Yan Yan == 22 °, "Pigment (4), etc. Red = 1 = pigment. These pigments can be The ❹ ❹ 亦 亦 配 配 配 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 适当 ' ' ' ' ' ' ' (4) In order to reduce the permeability of the wire of the (four) wire and prevent the deterioration of the chemical solution contained in the plastic knee ampule due to ultraviolet rays, 'specifically', for example, 2_(2, -hydroxy_5) , monomethylphenol) benzotriazole (Ciba Specialty Chemicals (trade name "TINUVIN (registered trademark) p" manufactured by Ciba Specialty Co., Ltd.), 2_(2, monohydroxy 3,5 bis (methylbenzyl) Phenol) benzotriazole (made by Ciba Specialty Chemicals Co., Ltd.) Trade name "(registered trademark) 234"), 2-/2'-hydroxy-3'-t-butyl-5'-nonylphenol)_5-gas benzotriazole (>% Bajing Chemical Co., Ltd.) The company's trade name is "TINUVIN (registered trademark) 326"), 2-(2,-hydroxy_3',5'-di-t-butylphenol)-5-chloro 9710774 24 200940046 benzobisazole (steam) Bajing Chemical Co., Ltd. "Τί_ίΝ (registered trademark) 327"), 2-(2, mono-based, 3, 5, trade name triamylphenol) benzotriazole (Ciba Specialty Chemicals Co., Ltd.; "τ 副 简 registered trademark" 328"), 2_(2, m = quotient butyl benzene age) benzotris(s) (Ciba Refinery Limited 4: Product name "Π_ΙΝ (registered trademark) 329" t Receiving agent, etc.
紫外線吸收劑之調配量,係根據形成外層2G 度、塑膠錢所要求之紫外線遮蔽性程度等而適當^曰, 可’並無特別限^,例如形成外層2G之樹脂中=p 0.01〜0.4重量%。 較佳為 於形成外層20之樹脂中調配紫外線吸收劑之情況 就提高紫外線吸收劑之吸收紫外線的效率、降低紫外吸 =劑之使用量之觀點而言,更佳為調配金屬氧化物微 于0 ❹ 作為金屬氧化物微粒子之金屬氧化物,例如可舉出··氧 化鈦、氧化鋅、氧化鐵、氧化鈽、氧化鎂等。 又’金屬氧化物微粒子之平均粒徑並無特別限定,就維 持塑膠安瓶之透明性之觀點而言,較佳為5〇咖以下,更 佳為30 run以下。 金屬氧化物微粒子之調配量,係根據所使用之紫外線吸 收劑之種類或其調配量、形成外層20之樹脂厚度、塑膠 安瓿所要求之透明性或紫外線遮蔽性程度等而適當設定 即可,並無特別限定,例如形成外層20之樹脂中,較佳 97110774 25 200940046 為0.01〜0.4重量%。 別^紫L卜線吸收劑與金屬氧化物微粒子之組合,並盤特 別限定,較佳為可舉出2_(2,,基 口並厂: 基苯酚)-5-氣苯并***(上述第二丁基_5 '甲 標〜與氧化辞微粒子之組TI贿1N(註冊商 層= 層19及外層2〇之各層厚度,任- ^::::由多層塑膠所形成之層整體㈣〜灣圍 2 度之比例可根據容納於塑膠安瓶之藥液之種 類、谷納里等而進行適當設定。 ^層塑膠之厚度係根據塑膠安瓶lG之用途、所容納之 :液,種類、容納量等而適當設定即可,並無特別限定, :如:容納部η中’較料3。〇〜15。…更佳為 0 # m。多層塑踢厚度於藥液容納部11、藥液排 出同部12及頂部13之各料㈣亦可互不相同。 ❺ 使多層塑膠裂開(扭斷或折裂)之跪弱部14所需之力, 即’***脆弱部14整體所需之扭矩,就使塑膠安瓿1〇開 封時之操作性之觀點而言,較佳係設定為G.4QN.m以下, 更佳係設定為〇.〇5〜〇.4〇 N.m。 又相對於藥液排出筒部12之多層塑膠之厚度,使脆 弱邛14裂開所需之力較佳為〇·65 N 以下,更佳為 〇.〇5〜〇.65N.m/mm。於鄰接於藥液排出筒部以之脆弱部 14且夕層塑膠之厚度大致均勻的部分,將使脆弱部14裂 ,所#之力(多層塑膠之厚度之每單位長度所需之力)設 疋為上述範圍,藉此可使用以使脆弱部14裂開之操作性 97110774 26 200940046 達到良好。 二:弱部14裂開所需之力’可根據形成多層塑膠之各 開户Γ雲曰之種=而適當調整。特別是就將使脆弱部14裂 整體之=n又疋為適當值之觀點而言,係相對於多層塑膠 之厚環狀烯烴(共)聚合物所形成之中間層 厚度較佳地投為25〜,更佳為30〜儀。 ❹ ❹ =及圖2所示,藥液容納部u於其外周面23上具 二:24,該凸緣24係於夹持藥液容納部η之令心軸 且’自藥液容納部η之外;:中二軸15之軸方向延伸’ 又,藥液容納部u係於其底部16:徑方向外侧突起者。 外側突起之凸、緣25,上述外 ’具備自底部16向 之凸緣25相互連續。周面23之凸緣24與底部16 該等相互連續之2個凸緣 瓶10之製造方法而生成。今等㈣5;係由於下述塑膠安 納部U之外周面23丄=:=25形成於藥液容 並謀求維持藥液容納心之形y各納部11賦予剛性, 如圖1及圖2所示,於藥液排中 具備掰片28,該掰片之外周面26上 起’向頂部13侧連續而突起於二=之= 侧’且’向頂部13之外表面27連„。"2之外 外側。 連續而突起於頂部13之 如此,因掰片28係自 於頂部13侧、與頂部13之二:部12之脆弱部14起, a1連續而形成,故握持藥液容 97110774 27 200940046 :邛1卜樂液排出筒部12之頂部13側 轉或脊曲之情況下,藥液容納部u與藥將該專相互扭 易變形。又,Μ ★ -Γ 4 伙徘出湾部12不 藉此可扭斷或折裂藥液排出筒部ϊ9 * # u’從且準確地進行塑膠安瓶iq 辦片28具有平板部29、及形成於平板部29:圍::。 角部30,粉手η 9» +〜 丨同圍之倒 …藉二8本^ 辦方W本身之剛性得到保持,並 封塑膠安瓶1〇而握持掰 、為了開 之變形。 乃“之清况下,可抑制掰片別 又,如圖1及圓?张- ^ 外用面Μ Η,所不’於肩部17之藥液容納部!!之 夕:面23’及自脆弱部14起的藥液容納部! 二 邻1Λ部?2之外周面26上’具備分別突起於藥液排出: 口Μ 2及樂液容納部u F出同 如此,增強片31二側、且相互連接之增強片3卜 藥液排出筒部12二::::切續形成’即,跨於自 位、與藥液容納部u之:部"17起之的广 容納部η與藥液排出筒部12間之;性故可顯者提尚藥液 藉此,例如於塑膠安瓿 容納部η突起之藥液排出筒部12;易=作中,自藥液 強ΓΓ:2:有掰 確地進行塑膠安飯10之開封作用’故可容易且準 增強片31具有平板部3 倒角部33,增強片31之心及形成於平板部32周圍之 内4形成中空狀之厚壁部分(參 97110774 28 200940046 照圖7)。藉此,增強片31本身 提高增強效果,並且於為了開封塑膠安瓶= 寺护進-步 片之情況下,可抑制增強片31之變形。且,=增強 28時,手指可良好地抓住增強片。 扭轉掰月 如圖2所示’增㈣31較料形成於 平面上。於該情況下,可獲得齊整外觀,且片=同之 ❹ =二T28時,手指易於抓住增強=塑 冉者增強片31亦可形成於與辦片28 —於製造塑谬安瓶10時,掰片28及增強二二 谷納部1卜藥液排出筒部12及 σ 一樂液 塑膠安瓿1〇孫々 〇Ρ之各部同時成形。 J 可藉由將專利文獻2所記载之所士田 *充·密封法、與多層吹塑成形二 方法而製造。 口之成形 作=二::熔:=多二_成形, 層18、黏著層黏/^、中間 而,,w 次外肩20而成的多層構造半成品。繼 h鑄模夹持所得之多層半成品,形成藥液容邮 排出筒部12及增強片31之各部(吹 Ί 二對合:液模容爽r 容納部排开=頁部13及辦片28,形成具備藥液 步驟),部12及頂部13之封閉區域(密封 糟此可獲得填充密閉有藥液之塑膠安瓿10。 於以對合禱模爽持半成品時,兩個凸緣 係沿者該對合鑄模之合攏面而形成。 25 97110774 29 200940046 密閉:’塑膠安瓿之成形、藥液之填充、安瓿之 異,且I因此可依低成本製造安全性、衛生性優 細邮,特疋里藥液(省略圖示)以密封狀態被填充於藥液容 1(及藥液排出筒部12)之狀態的成形品(塑膠安瓿 - 丄u)。 多層構造半成品可根據多層吹塑成形中之常法而製 2出機或模頭之形狀、多層構造半成品之成形條件等 ❹、’…、特別限定,根據多層吹塑成形中之常法適當設定即 可。 、矛i用使用多層構造半成品之吹塑填充·密封法製 &塑膠女瓶,除了半成品之層構造不同(形成半成品之擠 $機數量或模頭構造不同)以外,可以與利用使用單層構 造半成品之BFS法製造塑膠安瓿相同之方式來進行。再 者,多層薄膜之各層既可以上述之方式相互溶接而積層, 亦可於各層之間介隔由上述黏著性樹脂所形成之層而相 ❹互黏著。 本發明之塑膠安瓿例如可廣泛用於醫療用途。 進而,參照隨附圖式,詳細說明本發明之著色塑膠容器 之實施形態。 本發明之著色塑膠容器係由熱塑性多層塑膠形成,該熱 塑性多層塑膠具備:含有顏料及紫外線吸收劑之著色層, '及直接或夾持中間層而積層於上述著色層之一側表面的 内層。 圖8係表示形成著色塑膠容器之熱塑性多層塑膠之層 97110774 30 200940046 構成之一例的剖面圖,圖g及圖丨〇係分別表示上述熱塑 性多層塑膠之層構成之其他例的剖面圖。再者,以下說明 中,通過多個層構成例,對於相同或同種部分標示相同符 號。 -· 圖8所示之熱塑性多層塑膠具備:含有顏料及紫外線吸 收劑之著色層1(H、積層於著色層1〇1之一側表面之環狀 烯烴聚合物層1〇2、積層於環狀烯烴聚合物層1〇2之與著 ❹^層ι〇ι相對側表面之聚烯烴層103。於該熱塑性多層塑 膠中,著色層101係形成著色塑膠容器之外層之層,環狀 烯烴聚合物層102係形成著色塑膠容器之中間層之層,聚 烯烴層103係形成著色塑膠容器之内層之層。 環狀烯烴聚合物層102係為了防止調配於著色層之顏 料$紫外線吸收劑移動至容納於著色塑膠容器之内容物 而5又置之層,於形成本發明之著色塑膠容器之熱塑性多層 塑膠中為任意層。 〇 ® 9所示之㉟塑性多層詩具備:含有顏料及紫外線吸 收劑之著色们01、積層於著色層101之一側表面之3層 構造的中間層104、及積層於中間層1〇4之與著色層1〇1 相對侧表面之聚烯烴層103。又,中間層104具備:環狀 .烯烴聚合物層102 ’及於環狀烯烴聚合物層102之一側表 面及他側表面分別各積層丨層、共計2層之聚烯烴層丨〇5、 .106二於該熱塑性多層塑膠中,著色層101係形成著色塑 膠容器之外層之層,聚烯烴層103係形成著色塑膠容器之 内層之層。 ^ 97110774 31 200940046 圖Π)所示之熱塑性多層 層於聚烯烴層103之一 岬k層iUd檟 劑之著色層HHm 含有顏料及紫外線吸收 ,"—積層於著色層101之與聚烯烴層103 膠中大婦煙聚合物層1〇2。於該熱塑性多層塑 :::谢層103係形成著色塑膠容器之外層之層,環 二聚合物層102係形成著色塑膠容器之内層之層。 又,著色請係形成著色塑膠容器之中間層之層層之層 門:備二 =1〇所示之熱塑性多層塑膠,均可於各層 黏者劑層。於該情況下,例如可提高著色層m與 物層102之黏著性,環狀婦烴聚合物請 :=烯^旧之黏著性,著色層⑻與中間層ι〇4之黏 =’中間層104中之環狀烯烴聚合物層102與各聚稀烴 J:i〇6之黏著性’著色層1〇1與聚稀烴層1〇3之黏 〇 於本發明中,熱塑性多層塑膠之層構成並無特別限定, 例如為了對著色塑膠容器有效率地賦予遮光性,較佳為儘 可能於著色塑膠容器之外側配置著色層101。特別是該對 策於著色塑膠容器為安瓿等相對小型容器之情況下比較 有效。 、作為形成著色層之塑膠’除了具有熱塑性之塑膠以外, 並無特別限定,具體而言,例如可舉出聚烯烴。 /作為聚烯烴,並無特別限定,例如較佳為可舉出聚乙烯 系樹脂或聚丙烯系樹脂。再者’要求著色塑膠容器具有耐 熱性之情況下,較佳為聚丙烯系樹脂。 97110774 32 200940046 作為聚乙婦系樹脂,例如可舉出:高歷法(支鍵狀)低密 度聚乙稀(iiP-LDPE)、直鏈狀低密度聚乙婦(UDpE)、中密 度聚乙烯(MDPE)、高密度聚乙烯(HDPE)等均聚物,或聚乙 婦系,、t物作為聚乙稀系共聚物中之乙稀以外之共單 體,例如可舉出:丙稀、丁烯-1、戊稀-卜己烯-卜4-甲基戊稀卜辛婦4、癸烯一i冑α 一埽烴類。又,於該聚 ❹ ❹ 乙二系共聚物中,乙烯以外之共單體之含有比例,較佳為 20莫耳%以下,更佳為3〜2〇莫耳%。 聚乙烯系樹脂之性狀並無特別限定,例如較佳為相對較 低德、度,具體而言’較佳為密度為0.910〜〇.930 g/cm3 之範圍。。又’嫁融流動速率(猶)較佳為〇·2〜2〇_分 鐘(190。〇。就提高著色塑膠容器之力學特性方面而言, 聚乙細系樹脂之該等性狀較佳,特別是於著色層與内層之 間具備環狀烯烴聚合物層之情況下較佳。 作為聚丙烯系樹脂,例如可裹屮. 而樣心……, 4規聚丙烯、間規聚 ^專均H或聚㈣系共聚物。作為聚 =丙稀以外之共單體’例如可舉出:乙稀、丁二 烯-1、己烯-1、4-甲基戊烯4、辛烯Η、癸烯4 婦烴類。又,上述絲物巾之㈣以外之 例,較佳為30莫耳%以下,更佳為 之3有比 3〜25莫耳%。 更佳為2〜3〇莫耳%,特佳為 聚丙烯系樹脂之性狀並無特別限定 特性方面而言,_為上述範圍之聚丙歸系樹力: 97110774 33 200940046 著色層與内層之間具備環狀烯烴聚合物層之情況 β又’著色層例如可由聚丙婦、聚丙烯彈性體、成核劑之 -混合物形成。於該情況下,可提高著色層之透明性。 作為成核劑,例如可舉出:2,2,_亞甲雙(4, 6-二-第三 丁基苯基)磷酸鈉(NA—u)、雙[2,2-亞甲基_雙(46一二_ 第二丁基苯基)磷酸]羥基鋁(NA_21)等磷酸系成核劑等。 ❹—顏料係4 了降低著色塑膠容器之透光性、及抑制容納於 :色塑膠容器之内容物(例如,藥劑等。)因光線(特別是 紫外線)而產生之變質而調配之成分。又,除了上述目的 以外,例如為了對著色塑膠容器賦予創作性,亦可調配顏 料。 / 作為著色層中所含之顏料,可根據容納於著色塑膠容器 j内容物種類’ ,就提高上述内容物之保存性之方面而 δ,應遮蔽之光線之波長區域,而進行適當設定。 ❹ ^體而言’容納於著色塑膠容器之内容物主要係於應遮 蔽i外區域之光線者之情況下,作為顏料,例如可舉出·· 偶氮縮合系顏料(例如,以下述式表示之c.丨.顏料黃的、 以下述式表示之匕1·顏料黃93、以下述式表示之C I.顏 料黃94、以下述式表示之C. I.顏料黃128、C. I.顏料紅 、C. I.顏料紅22〇、c·丨.顏料紅221、c.丨.顏料紅 )異弓丨木琳酮系顏料(例如,以下述式表示之ς I顏 ,黃lio'c.i·顏料黃109、C I.顏料黃139、C I.顏料 黃173、C. I·顏料橙61、c丨·顏料橙68等)、單偶氮系顏 97110774 34 200940046 料(例如,C. I.顏料黃181等)、雙偶氮系顏料(例如,c. L 顏料黃180等)、蒽酿系顏料(例如,c. I ·顏料黃147等)、 二°等°井系顏料、喹吖啶酮系顏料等有機顏料,或例如氧化 鐵、C. I.顏料藍28(鈷藍;鋁酸鈷)、C. I·顏料黃53(鈦黃; 錄黃)等無機顏料。 [化3] [化4] h3(The amount of the ultraviolet absorber is appropriately determined according to the degree of 2G of the outer layer and the degree of ultraviolet shielding required by the plastic money, and can be 'not particularly limited, for example, the resin forming the outer layer 2G = p 0.01 to 0.4 weight. %. Preferably, in the case where the ultraviolet absorber is blended in the resin forming the outer layer 20, it is preferable to adjust the metal oxide to be less than 0 from the viewpoint of improving the ultraviolet absorbing efficiency of the ultraviolet absorbing agent and reducing the amount of the ultraviolet absorbing agent. ❹ The metal oxide of the metal oxide fine particles may, for example, be titanium oxide, zinc oxide, iron oxide, cerium oxide or magnesium oxide. Further, the average particle diameter of the metal oxide fine particles is not particularly limited, and from the viewpoint of maintaining the transparency of the plastic ampoules, it is preferably 5 Å or less, more preferably 30 run or less. The amount of the metal oxide fine particles to be added may be appropriately set depending on the type of the ultraviolet absorber to be used or the amount thereof to be blended, the thickness of the resin forming the outer layer 20, the transparency required for the plastic ampule, or the degree of ultraviolet shielding property, and the like. It is not particularly limited. For example, in the resin forming the outer layer 20, it is preferably 0.0110774 25 200940046, which is 0.01 to 0.4% by weight. The combination of the violet L-line absorber and the metal oxide microparticles is particularly limited, and preferably 2_(2,, base: phenol)-5-gas benzotriazole (described above) The second butyl _5 'A standard ~ and the group of oxidized granules TI bribe 1N (Registrar layer = layer 19 and outer layer 2 〇 each layer thickness, any - ^:::: the layer formed by the multilayer plastic (4) The ratio of 2 degrees to the circumference of the bay can be appropriately set according to the type of liquid contained in the plastic ampoules, the guar, etc. The thickness of the layer plastic is based on the use of the plastic ampoules, the liquid: It is not particularly limited as long as it is appropriately set in the accommodation amount, and the like: For example, in the accommodating portion η, 'Comparatively 3' 〇 15 15 is more preferably 0 # m. The multilayer plastic kick thickness is in the chemical liquid accommodating portion 11, The materials (4) of the same portion 12 and the top portion 13 of the liquid medicine discharge may be different from each other. 所需 The force required to break the weakened portion 14 of the multilayer plastic (twist or fracture), that is, the 'dividing fragile portion 14 as a whole The required torque is preferably set to G.4QN.m or less, and more preferably set to 〇.〇5, from the viewpoint of the operability of the plastic ampule. 〇.4〇Nm. The force required to rupture the fragile crucible 14 relative to the thickness of the multi-layered plastic of the discharge portion 12 of the liquid medicine is preferably 〇·65 N or less, more preferably 〇.〇5~〇. 65 N.m/mm. The force of the fragile portion 14 is split in a portion adjacent to the fragile portion 14 of the liquid discharging portion of the chemical liquid and the thickness of the layer of the plastic layer is substantially uniform (the force per unit length of the thickness of the multilayer plastic) The required force is set to the above range, whereby the operability 97110774 26 200940046 which can be used to rupture the fragile portion 14 is good. 2: The force required for the weak portion 14 to be split can be determined according to the formation of the multilayer plastic The appropriate type of 开 曰 = = 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 The thickness of the intermediate layer formed is preferably 25~, more preferably 30~. ❹ ❹ = and as shown in Fig. 2, the liquid receiving portion u has two: 24 on the outer peripheral surface 23 thereof, the flange 24 Attached to the mandrel holding the chemical liquid containing portion η and 'outside the chemical liquid containing portion η;: extending in the axial direction of the second axis 15' The accommodating portion u is formed on the bottom portion 16 of the bottom portion 16 in the radial direction. The convex portion of the outer protrusion and the edge 25 are continuous with the flange 25 from the bottom portion 16. The flange 24 and the bottom portion 16 of the peripheral surface 23 are the same. It is produced by the method of manufacturing two flanged bottles 10 which are continuous with each other. The present invention (4) 5; is formed by the following plastic surface of the plastic portion U: 23 丄 =:=25 is formed in the liquid medicine and seeks to maintain the shape of the liquid containing the liquid. Each of the y portions 11 is provided with rigidity. As shown in Fig. 1 and Fig. 2, the sputum sheet 28 is provided with a cymbal sheet 28, and the outer peripheral surface 26 of the cymbal sheet is continuous toward the top portion 13 and protrudes on the side of the second = side. 'And' to the outer surface 27 of the top 13 is connected. "2 outside. Continuously protruding from the top portion 13, since the cymbal sheet 28 is formed from the top 13 side and the fragile portion 14 of the second portion: the portion 12 of the top portion 12, a1 is continuously formed, so that the liquid medicine capacity is held 97110774 27 200940046 : In the case where the top 13 of the bulu liquid discharge cylinder portion 12 is turned sideways or ridged, the chemical liquid accommodating portion u and the medicine are twisted and deformed. Μ Γ Γ Γ * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Formed on the flat plate portion 29: circumference::. Corner 30, powder hand η 9» +~ 丨同围倒倒... Borrowing two 8 pieces ^ The rigidity of the office W itself is maintained, and the plastic ampoules are sealed and held in order to open the deformation. It is "under the condition, it can suppress the sputum film, as shown in Figure 1 and the circle? Zhang - ^ external use Μ Η, not in the shoulder 17 of the liquid storage compartment!! On the evening: face 23' and from The liquid medicine accommodating portion of the fragile portion 14 is located on the outer peripheral surface 26 of the two adjacent portions, and is provided with a separate protrusion for the discharge of the chemical liquid: the mouth Μ 2 and the liquid accommodating portion u F are the same, and the reinforcing sheet 31 is on both sides. And the reinforcing sheets 3 connected to each other are discharged from the tubular portion 12:::: continually forming 'that is, across the self-position, and the accommodating portion u: the portion of the wide portion η of the portion " The liquid medicine is discharged from the tube portion 12; the sexual liquid can be used to raise the liquid medicine, for example, the liquid medicine discharge tube portion 12 protruding in the plastic ampoule accommodating portion η; easy to work, the self-medicated liquid is strong: 2: The opening of the plastic rice 10 is accurately performed. Therefore, the sheet 31 has the flat portion 3 chamfered portion 33, and the center of the reinforcing sheet 31 and the inner portion 4 formed around the flat portion 32 are hollow. The wall portion (refer to 97110774 28 200940046 according to Figure 7). Thereby, the reinforcing sheet 31 itself enhances the reinforcing effect, and can be suppressed in order to open the plastic ampoules = temple guard-step film The deformation of the strong piece 31. Moreover, when the weight is increased by 28, the finger can grasp the reinforcing piece well. The twisting of the moon is as shown in Fig. 2, and the addition (four) 31 is formed on the plane. In this case, a uniform appearance can be obtained. And the film = the same ❹ = two T28, the finger is easy to grasp the reinforcement = plastic reinforced sheet 31 can also be formed in the same with the film 28 - in the manufacture of plastic ampoules 10, smashed 28 and enhanced di quaternary Each part of the first liquid medicine discharge tube portion 12 and the σ-le liquid plastic ampule 1 〇 々〇Ρ 同时 同时 同时 同时 J J J J J J J J J J J J J J J J J J J J J J J J J J J Blow molding two methods to manufacture. The formation of the mouth = two:: melt: = more than two - forming, layer 18, adhesive layer adhesion / ^, the middle, w sub-shoulder 20 made of multi-layer semi-finished products. h mold clamping the obtained multi-layer semi-finished product to form each part of the liquid medicine discharge post 12 and the reinforcing sheet 31 (blowing two pairs: liquid mold cooling r housing portion discharging = page portion 13 and handling sheet 28, forming With the chemical liquid step), the closed area of the part 12 and the top 13 (the sealed case can be obtained by filling the plastic ampoule 10 with the liquid medicine sealed.) When the semi-finished product is held in the mold, the two flanges are formed along the closing faces of the pair of molds. 25 97110774 29 200940046 Sealing: 'The formation of plastic ampoules, the filling of liquid medicine, the difference in ampoules, and therefore A molded article (plastic) in which the drug solution (not shown) is filled in the sealed state in the state of the drug solution 1 (and the drug discharge tube portion 12) can be manufactured at a low cost. Ampoule - 丄u). The multilayered semi-finished product can be made according to the usual method in multi-layer blow molding, the shape of the machine or the die, the forming conditions of the multilayered semi-finished product, etc. The usual method in the middle can be set appropriately. The spear i is made of a blow molding filling and sealing method using a multi-layered semi-finished product. The plastic female bottle can be used in addition to the layer structure of the semi-finished product (the number of the semi-finished products is different or the die structure is different). The semi-finished BFS method is used to make plastic ampoules in the same way. Further, the respective layers of the multilayer film may be laminated to each other in the above-described manner, or may be adhered to each other by interposing layers formed of the above-mentioned adhesive resin. The plastic ampoules of the present invention are widely used, for example, in medical applications. Further, an embodiment of the colored plastic container of the present invention will be described in detail with reference to the accompanying drawings. The colored plastic container of the present invention is formed of a thermoplastic multilayer plastic comprising: a coloring layer containing a pigment and an ultraviolet absorber, and an inner layer laminated directly or sandwiching an intermediate layer to one side surface of the colored layer. Fig. 8 is a cross-sectional view showing an example of a structure of a thermoplastic multilayer plastic forming a colored plastic container. 97110774 30 200940046, and Fig. g and Fig. 3 are cross-sectional views showing other examples of the layer structure of the thermoplastic multilayer plastic, respectively. Further, in the following description, the same symbol is denoted by the same or the same type in a plurality of layer configuration examples. - The thermoplastic multilayer plastic shown in Fig. 8 is provided with a coloring layer 1 containing a pigment and an ultraviolet absorber (H, a cyclic olefin polymer layer laminated on one side surface of the colored layer 1〇1, 2, laminated in a ring The polyolefin layer 103 of the olefin polymer layer 1 2 opposite to the side surface of the layer ι ι. In the thermoplastic multilayer plastic, the colored layer 101 forms a layer of the outer layer of the colored plastic container, and the cyclic olefin is polymerized. The layer 102 forms a layer of the intermediate layer of the colored plastic container, and the polyolefin layer 103 forms a layer of the inner layer of the colored plastic container. The cyclic olefin polymer layer 102 is designed to prevent the pigment ultraviolet ray adsorbent disposed on the colored layer from moving to The layer contained in the colored plastic container and the layer 5 is placed in any layer of the thermoplastic multilayer plastic forming the colored plastic container of the present invention. The 35 plastic multilayer poem shown by 〇® 9 has: a pigment and an ultraviolet absorber. The coloring layer 01, the intermediate layer 104 of a three-layer structure laminated on one side surface of the colored layer 101, and the polyolefin layer 103 laminated on the opposite side surface of the intermediate layer 1〇4 with the coloring layer 1〇1. 104: a ring-shaped olefin polymer layer 102' and a layer of tantalum layer on one side surface and one side surface of the cyclic olefin polymer layer 102, respectively, and a total of two layers of polyolefin layer 丨〇5, .106 In the thermoplastic multilayer plastic, the colored layer 101 forms a layer of the outer layer of the colored plastic container, and the polyolefin layer 103 forms a layer of the inner layer of the colored plastic container. ^ 97110774 31 200940046 The thermoplastic multilayer layer shown in Fig. The coloring layer HHm of one of the 岬k layer iUd enamels contains pigment and ultraviolet absorbing, "-layered on the colored layer 101 and the polyolefin layer 103 in the polyolefin layer 103. The thermoplastic multilayer mold ::: layer 103 forms a layer of the outer layer of the colored plastic container, and the ring polymer layer 102 forms a layer of the inner layer of the colored plastic container. In addition, the coloring is to form a layer of a layer of the intermediate layer of the colored plastic container. The thermoplastic multilayer plastic shown in Table 2 = 1 , can be applied to each layer of the adhesive layer. In this case, for example, the adhesion of the colored layer m to the object layer 102 can be improved, and the cyclic hydrocarbon polymer should have the following adhesion: the adhesion of the colored layer (8) to the intermediate layer ι 4 = 'intermediate layer The adhesive of the cyclic olefin polymer layer 102 in 104 and the adhesion of each of the polythene J: i〇6, the colored layer 1〇1 and the polythene hydrocarbon layer 1〇3, in the present invention, the layer of the thermoplastic multilayer plastic The configuration is not particularly limited. For example, in order to impart light-shielding properties to the colored plastic container, it is preferable to arrange the colored layer 101 as much as possible on the outer side of the colored plastic container. In particular, it is effective in the case where the colored plastic container is a relatively small container such as an ampoule. The plastic which is a coloring layer is not particularly limited as long as it has a thermoplastic plastic, and specific examples thereof include polyolefin. The polyolefin is not particularly limited, and examples thereof include a polyethylene resin or a polypropylene resin. Further, in the case where the colored plastic container is required to have heat resistance, a polypropylene resin is preferable. 97110774 32 200940046 As the polyethylidene resin, for example, a high-calendar (supported) low-density polyethylene (iiP-LDPE), a linear low-density polyethylene (UDpE), a medium-density polyethylene ( a homopolymer such as MDPE), high-density polyethylene (HDPE), or a poly-glycol, and a t-thin as a co-monomer other than ethylene in the polyethylene-based copolymer, and examples thereof include acrylonitrile and butyl. Alkene-1, pentacene-p-hexene-Bu 4-methylpentazone 4, terpene-i胄α-anthracene hydrocarbon. Further, in the poly(fluorene) ethylene-based copolymer, the content ratio of the comonomer other than ethylene is preferably 20 mol% or less, more preferably 3 to 2 mol%. The properties of the polyethylene-based resin are not particularly limited. For example, it is preferably relatively low in degree, and specifically, the density is preferably in the range of 0.910 to 930.930 g/cm3. . Also, the rate of grafting flow (June) is preferably 〇·2~2〇_min (190. 〇. In terms of improving the mechanical properties of the colored plastic container, the properties of the polyethylene resin are better, especially It is preferable in the case where a cyclic olefin polymer layer is provided between the colored layer and the inner layer. As the polypropylene-based resin, for example, it can be wrapped in a crucible. The core of the sample is 4 gauge polypropylene, and the syndiotactic poly-specific H Or a poly(tetra) copolymer. Examples of the co-monomer other than poly-propylene include ethylene, butadiene-1, hexene-1, 4-methylpentene 4, octene fluorene, and anthracene. Further, in the case of the above-mentioned silk towel, it is preferably 30 mol% or less, more preferably 3 or more than 3 to 25 mol%. More preferably 2 to 3 mol%. %, particularly preferably, the properties of the polypropylene-based resin are not particularly limited in characteristics, and _ is the polyacrylic acid of the above range: 97110774 33 200940046 The case of having a cyclic olefin polymer layer between the colored layer and the inner layer β Further, the colored layer can be formed, for example, from a mixture of polypropylene, polypropylene elastomer, and nucleating agent. In this case, coloring can be improved. The transparency of the layer. As the nucleating agent, for example, 2,2,-methylenebis(4,6-di-t-butylphenyl)phosphate (NA-u), bis[2,2 - a nucleating agent such as a methylene _ bis ( 46 1-2 butyl butyl phenyl phosphate ) hydroxy aluminum (NA_21) or the like. ❹ - pigment system 4 reduces the light transmittance of the colored plastic container and suppresses The ingredients contained in the color plastic container (for example, pharmaceuticals, etc.) are formulated by deterioration of light (especially ultraviolet rays). In addition to the above purposes, for example, in order to impart creativity to the colored plastic container, Adjustable pigments. / As the pigment contained in the colored layer, it can be adjusted according to the type of content contained in the colored plastic container j, in order to improve the preservation of the above contents, δ, the wavelength region of the light to be shielded In the case where the contents of the colored plastic container are mainly used to shield the light in the outer region of the i, the pigment may be, for example, an azo condensation pigment (for example, the following) The expression of c. 丨. pigment yellow, by the following formula匕1·Pigment Yellow 93, C I. Pigment Yellow 94 represented by the following formula, CI Pigment Yellow 128, CI Pigment Red, CI Pigment Red 22〇, c·丨. Pigment Red 221, c.丨.Pigment red) 丨 丨 丨 琳 系 ( ( ( ( ( ( ( ( ( ( ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς ς C. I·Pigment Orange 61, c丨·Pigment Orange 68, etc.), monoazo-based pigment 97110774 34 200940046 (for example, CI Pigment Yellow 181, etc.), disazo pigment (for example, c. L Pigment Yellow 180 Etc.), brewing pigments (for example, c. I. Pigment Yellow 147, etc.), ii, etc., organic pigments such as well pigments, quinacridone pigments, or, for example, iron oxide, CI Pigment Blue 28 (cobalt blue) Inorganic pigments such as cobalt aluminate), C.I. Pigment Yellow 53 (titanium yellow; yellow). [化3] [化4] h3(
ClCl
.3 (C.I.顏料黃95).3 (C.I. Pigment Yellow 95)
Cl OC-NH CH3 {Cl OC-NH CH3 {
Cl ¢1Cl ¢1
coch3 hc-n=n HN-COCoch3 hc-n=n HN-CO
〇C-NH 0〇ch3 H3C\ HN-CO Cl〇C-NH 0〇ch3 H3C\ HN-CO Cl
(C.l.顔料黃93> 97110774 35 200940046 [化5](C.l. Pigment Yellow 93> 97110774 35 200940046 [Chem. 5]
ClCl
COCH3COCH3
N=N-CH (C.I·顏料黃94〉 [化6]N=N-CH (C.I·Pigment Yellow 94> [Chem. 6]
COCH3COCH3
N=N-CH (C.l.顏料黃128〉 97110774 36 200940046 [化7]N=N-CH (C.l. Pigment Yellow 128> 97110774 36 200940046 [Chem. 7]
其中’就有效率地遮蔽紫外區域之光線之觀點而言,顏 料較佳為偶氮縮合系黃色顏料。又,例如即便容納於著色 』膠谷器之藥劑為奥紮格雷鈉(g〇dium 〇zagrei )水溶液 之情況下,就提高抑制奥紮格雷鈉變質之效果之觀點而 言,顏料亦較佳為偶氮縮合系黃色顏料,特佳為C.I.顏 料黃9 5。 φ 雷鈉水溶液等藥劑等 成分。 紫外線吸收劑係為了降低著色塑膠容ϋ之紫外線透過 ί·生及抑制今納於著色塑膠容器之内容物(例如,奥紫格 。)因紫外線而產生之變質而調配之The pigment is preferably an azo condensation yellow pigment from the viewpoint of efficiently shielding the light in the ultraviolet region. Further, for example, even when the agent contained in the colored yoghurt is an aqueous solution of sodium zagreli (g〇dium 〇zagrei), the pigment is preferably improved from the viewpoint of improving the effect of suppressing deterioration of sodium ozagrel sodium. The azo condensation is a yellow pigment, particularly preferably CI Pigment Yellow 9 5. φ Resodium sodium solution and other ingredients. UV absorbers are formulated to reduce the UV transmission of colored plastics and to inhibit the deterioration of the contents of colored plastic containers (eg, Aegis) due to UV rays.
97110774 g 口口名「ΤΙΝϋΠΝ(註冊商 甲基苯酚)苯并***(汽巴精 37 200940046 化股份有限公司製造之商品名「TINUVIN(註冊商標)p」)、 2_(2’ -經基-3’,5’ -雙(甲基苄基)苯酚)苯并***(汽巴精 化股份有限公司製造之商品名「TINUVIN(註冊商 '標)234」)、2 — (2’_羥基~3’,5,-二-第三丁基苯酚)-5-氯 笨并二唾(汽巴精化股份有限公司製造之商品名 「TINUVIN(註冊商標)327」)、2-(2,-羥基-3,,5,_二-第 二戊基苯齡)苯并***(汽巴精化股份有限公司製造之商 ❹品名「TINUVIN(註冊商標)328」)、2_(2, 一羥基_5,_四甲 基丁基苯酚)苯并***(汽巴精化股份有限公司製造之商 品名「TINUVIN(註冊商標)329」)等苯并***系紫外線吸 收劑等。 又,例如即便容納於著色塑膠容器之藥劑為奥紮格雷鈉 (具體而言’其水溶液、單體等。)之情況τ,紫外線吸收 劑亦較佳為苯并***系,特佳為商品名「tinuvin(註冊 標)326」。 ❹進而’視需要可於著色層中調配顏料及紫外線吸收劑以 外之各種添加劑。 匕例如,就提高紫外線吸收劑之吸收紫外線的效率、降低 紫外線吸收劑之使用量之觀點而言,進而可一同含有紫外 線吸收劑,以及金屬氧化物微粒子。 、 作為金屬氧化物微粒子之金屬氧化物,例如可舉出·氧 化鈦、氧化鋅、氧化鐵、氧化筛、氧化鎮等。又 外線吸收劑與金屬氧化物微粒子之組合,並無特別限定: 列如較佳為可舉出上述商品名「ΤΙΝϋνΐΝ(註冊商標加6 97110774 38 200940046 與氧化鋅微粒子之組合。 内層係由具有熱塑性之塑膠所形成之層,具體而言,例 如,如上所述,例如可舉出聚稀烴層、環狀稀煙聚合物層 等。 作為形錢烯烴層之聚烯煙,可舉出與形成著色 膠相同者。 ❹ ❹ 作為形成環狀稀烴聚合物層之環狀烯烴聚合物,例如可 舉出:環狀烯烴與烯烴之共聚物、環狀烯烴之開環聚人 物、該等之氫化物等。具體而言,例如可舉出:乙稀與: 環戊二烯類之共聚物、乙婦與降福婦系化 f戊二締衍生物之開環聚合物、2種以上之環Η:生 物之開環共聚物、該等之氫化物。其中,較佳可舉出:乙 稀與降福婦系化合物之共聚物之氮化物、i種或2種以上 之f戊二烯衍生物之開環(共)聚合物之氫化物。 稭由設置環狀稀烴聚合物層作為内層,可防止著色層中 之顏料或紫外線吸收劑移動至著色塑膠之内容物。進而, 可提高著色塑膠容器之機械強度或防透水能力,或者對著 色塑膠容器賦予防透氣能力。 ,狀婦烴聚合物之玻璃轉移溫度㈤並無特別限定,例 如,為藉由《IIS K 71 21.1987「塑膠之轉移溫度測定方法」 二=载之功率補償示差掃描熱析儀(功率補償ds〇所測定 、中間點玻璃轉移溫度(Trag),較佳為6 65〜8〇t:。 υ更佳為 右%狀烯烴聚合物之Tg超過8(rc,則產生如下不良情 97110774 39 200940046 況:例如於著色塑膠容器為下述安瓿之情況下,於***安 瓶而產生之開口部上殘存有稱作「毛刺」之細樹脂片,或 者***所需之力變得過大。相反,若環狀烯烴聚合物之 '· Tg低於60 c ’則存在如下擔憂:防止著色層中之顏料或 •紫外線吸收劑移動之效果、或防止氣體及水蒸氣透過能力 下降。 環狀烯烴聚合物之熔融流動速率(舯趵並無特別限定, 就著色塑膠容器之成形性或力學特性等觀點而言,較佳為 4〜30 g/ΙΟ 分鐘(26〇。(:)。 環狀烯烴聚合物之分子量並無特別限定,數量平均分子 量<Mn>較佳為1萬〜丨〇萬,更佳為2萬〜5萬。再者,平 均分子量係例如藉由以環己烷為溶劑之凝膠滲透層析法 (GPC)分析,作為標準聚苯乙烯換算值而求得。 中間層係由具有熱塑性之塑膠所形成之層。作為中間層 之具體例,例如可舉出: ❹ (a)環狀烯烴聚合物層, (b) 具備環狀烯烴聚合物層’及於該環狀烯烴聚合物層 之一側表面及另一侧表面分別各積層1層、共計2層之聚 烯烴層的3層構造之積層體, (c) 著色層, : 等。 * 作為形成上述聚烯烴層之聚烯烴、或形成上述環狀烯烴 聚合物層之環狀烯烴聚合物,可舉出與上述相同者。 如上述(a)及(b)所示,即便以環狀烯烴聚合物層為中間 97110774 40 200940046 層之情況下,亦可獲得與以環狀婦煙聚合物層為内層之 =相同之作用效果。即,可獲得防止著色層中之顏料及^ 夕線吸收劑移動至著色塑膠容器之内部的效果,或提古菩 容器之強度的效果,進而,可獲得提高防止水:及 •氣體透過之能力的效果。 為了提高制之黏著性、或減輕著色塑膠容器之硬产, 可於作為中間層之環狀烯烴聚合物層中適當調配聚乙ς。 ❹ 為==生ί層塑膠之透明性之觀點而言,調配於作 =1體二聚合物層之聚乙烯’較佳為相對較高 又者/、體而5,例如較佳為密度為0. 935〜〇. 9 乙:二’相對於1〇。重量份之環狀烯煙聚合物層之 〜里聚乙烯之含有比例較佳為5〜20重量份。 ❹ 又,於著色層為形成著色塑膠容器之中間層之 ::作為形成著色層之塑膠,或著色層中所含之顏料:: 卜線吸收劑、其他添加劑,可舉出與上述相同者。、 視需要’例如亦可於上述熱塑性多層塑膠中 層、阻氣層、氧氣吸收層、密封層等層。 作為黏著層,壯可舉出:h飽和羧較 乙烯-丙烯酸共聚物、乙稀_酸: 月曰料成之層。又,作為黏著層之其他例,例如 ==度聚乙烯,特別是藉由二茂金屬等所謂 層以合之密度為—。一聚乙缔所形= 於本發明之著色塑膠容器中,著色層之厚度1可設定為 97110774 200940046 50〜1 000 。 若著色層之厚度T低於50 /zm,則難以將用以發揮本 發明之作用效果所需之充分量的顏料或紫外線吸收劑調 ·配於著色層中。相反,若著色層之厚度T超過1 000 /zm, *·則熱塑性多層塑膠整體之厚度變得過大,從而著色塑膠容 器之成形性或操作性下降。 著色層之厚度T於上述範圍内特佳為50〜4〇() ,更 ❹佳為50〜300 。特別是於著色塑膠容器為著色塑膠安 瓿之情況下,著色層之厚度τ較佳為5〇〜3〇()以m。 於本發明之著色塑膠容器中,將著色層中之顏料之含有 比例P(重量%)、與著色層之厚度τ( # m)之積ρτ,設定為 滿足下述式(1)。 1 ^ PT^ 150--(1) ❹ 2由將積ΡΤ之值設定為上述式(1)之範圍内,並且將下 述著色層中之紫外線吸收劑之含有比例ϋ(重量幻、與上 述者色層之厚度T( am)之積UT設定為下述範圍内,可維 持對容器内部之適度可見性’並且有效率地遮蔽紫外區域 之波長光。相對於此,_ PT <值低於上述範圍, 外區域之波長光之遮蔽效果不充分。相反,若ρτ之值超 過上述範圍,則難以確認著色塑膠容器内部之情況。 ?ΡΤ之值於上述範圍内特佳為5〜12〇’更佳為5〜⑽。 者=層中之著色劑之調配量,與著色層之厚度τ之關係 :,除y設定為滿足上述式⑴之範圍以外,並無特 疋’就著色層中之分散性等觀點而言,例如於著色層中^ 97110774 42 200940046 含有比例較佳為0 · 〇 1〜〇 _ 4重量%。 於本發明之著色塑膠容器中,將著色層中之紫外線吸收 劑之含有比例U(重量%)、與著色層之厚度T(/Zm)之積υτ -·設定為如下:於著色層中之顏料之含有比例ρ(重量%)、 -與著色層之厚度T(#m)之積ΡΤ超過20時滿足下述式 (2),且,上述積pT為2〇以下時滿足下述式(3)。 5SUTS 160...(2) 20< UTS 160·.. (3) ❹藉由將積υτ之值設定為上述式(2)或(3)之範圍,並將 上述積ΡΤ之值設定為上述式(1)之範圍,可維持對容器内 部之適度可見性,並且可有效率地遮蔽紫外區域之波長 光。 相對於此,若積UT之值,於積ΡΤ超過20時低於上述 式U)之範圍,或者,於積打為2〇以下時低於上述式 之範圍,則紫外區域之波長光之遮蔽效果不充分。相反, ❹若UT之值超過上述範圍,則存在如下擔憂:著色層中之 紫外線吸收劑之分散性下降。 積ΡΤ超過20之情況下,積υτ之值於上述範圍内特佳 為5〜120 ’更佳為10〜1〇〇。 =一方面,積ΡΤ為20以下之情況下,積叮之值於上 述範圍内特佳為30〜160,更佳為35〜16〇。 . 者色層中之紫外線吸收劑之調配量,與著色層之厚度τ 之關係中,除了設定為滿足上述式⑵之範圍以外,並無 特別限定,就於著色層中之分散性等觀點而言,例如於著 97110774 43 200940046 色層中之含有比例較佳為〇. 01〜0. 4重量%。 又’於著色層之他侧表面為熱塑性多層塑膠之外側表面 之情況下’即’著色層為形成著色塑膠容器之外層之層的 •情況下’較佳為將著色層中之紫外線吸收劑之含有比例 • ϋ(重量%)除以著色層之厚度T(/zm)時之商U/T,設定為滿 足下述式(4)。 U/TS 0· 004...⑷ _ 若商U/T超過上述範圍,則存在如下擔憂:紫外線吸收 劑自著色層滲出至著色塑膠容器之外部。 商U/T之值於上述範圍内特佳為〇· 0038以下,更佳為 〇.0001〜〇.〇〇38 。 於本發明之著色塑膠容器中,著色層以外之各層厚度相 對於由熱塑性多層塑膠形成之層整體,較佳為均設定於 10’之範圍。再者’各層厚度之比例,可根據容納於 夕層塑膠容器之内容物種類、容納量等而適當設定。 ❹熱塑,多層塑膠整體之厚度,根據著色塑膠容器之用 :所谷納之内容物種類、容納量等而適當設定即可,並 =別限疋’例如較佳為300〜1500 〃m,更佳為400〜 1 WO # m。 作為容納於本發明之著色塑膠容器之藥劑’並無特別限 列如較佳為可舉出奥紮格雷鈉水溶液。 如可it:之:色塑膠容器之形態,並無特別限定,例 牛出文瓶、柔軟性袋用容器、瓶等。 圖U係表示作為著色塑膠容器之—實施形態之著色塑 97110774 44 200940046 膠安親之-例的前視圖,圖12係其側視圖,圖i3係俯視 圖’圖14係仰視圖’圖15係側剖面圖。 如圖11及圖12所示’著色塑膠安瓶11〇具備·形成為 有底筒狀之用以容納藥液之藥液容納部lu、與藥液容納 部m之開口端⑴a連通並向一侧延伸之藥液排出筒部 112、及封閉藥液排出筒部112之一側端部之頂部⑴; ❹ 並且藥液排出筒部112具備沿著圓周方向形成為薄壁之 脆弱部114。 於藥液容納部111中,於沿著藥液容納部⑴之中心軸 115之長度方向上,於與底部116相對之—側端部形成有 於該開口端llla之附近,具有其徑自底部 116侧面向開口端⑴“則(一侧)變小之肩部m。 =3及圖14所示,藥液容納部lu之剖面形 俯視或仰視中形成為圓形狀,但藥液容納部⑴之 面形狀並不限定於此,例如亦可形成為橢圓狀。 ::參照圖11及圖12 ’藥液排出筒部112係以如下方 自藥液容納部lu之開口wlla連續,以與藥 :谷:部⑴之中心轴115相同之轴為中心軸,而沿著ς 二軸m之軸方向延伸。於藥液排出筒部112之一側: 端ln f液排出筒部112中’與藥液容納部111之開口 a侧相對之侧的端部),自上 封鎖藥液排出筒部112之頂部113。側^連續,形成 部==Μ係在例如***有用以吸取藥液容納 之樂液之注射器喷嘴的情況下,較佳為具有如與 97110774 45 200940046 上述喷嘴相適合之内徑,以便以穩定之狀態固定該喷嘴, 又,較佳為於藥液容納部ln與頂部113之間,於藥液排 出筒部112之轴方向上具有充分之長度。 藥液容納部ill、藥液排出筒部112及頂部113相互連 續成為一體,並形成用以容納及密封藥液之封閉區域。 又,藥液排出筒部112係於自藥液容納部丨丨丨之開口端 111a至藥液排出筒部112之一側端部間之大致中間部 分,具備沿著藥液排出筒部112之圓周方向形成為薄壁之 脆弱部114(參照圖15)。 藉此,握持藥液容納部m、藥液排出筒部ιΐ2之頂部 113侧’將該等相互扭轉或f曲,藉此可易於將脆弱部⑴ 扭斷或折裂、***。又,藉此可使著色塑膠安瓶110開封。 ❹ 又,藉此成為如下狀態:將藥液排出筒部112開口,於 :此產生之開口部***省略圖示之注射器噴嘴,從而可採 集容納於藥液容納部U1内之藥液。再者,注射器係以如 :方式進行制H如於㈣嘴之前端未附帶注射針之狀 ,下’將喷嘴***至藥液排出筒部112之開σ,從而吸取 谷納於藥液容納部111内之藥液。 如圖11及圖12所示,藥液容納部lu係於其外周面 上具備凸緣124’該凸緣124係於夾持藥液容納部iu 2心轴m而相互相對之位置上,沿著中心軸115之軸 :向:伸,且,自藥液容㈣⑴之外周面123向徑方向 ^大起者。又’藥液容納部ln於其底部116上,且備 自底部116向外側突起之凸緣125,上述外周面123^凸 97110774 46 200940046 緣124與底部116之凸緣125相互連續。 111 之2,凸緣124、125形成於藥液容納部 並m給L + 藉此可對藥液容納部111賦予剛性, 並°某求維持藥液容納部111之形狀。 如圖11及圖12所示’於藥液排出筒 112:外側起,自頂部113側連續而突起於藥液排出筒部 側且自頂部113之外表面__ 如128係自藥液排出筒部112之脆弱部⑴ :藥:::113側、與頂部113之間連續而形成,故在握 部ln、藥液排出筒部112之頂部113侧而 轉或f曲之情況下,藥液容納部⑴與藥液 ❹ 筒部m之脆弱部:從又而裂藥液排出 膠安瓶m之開封操作。 易且準確地進行著色塑 倒:二具有平板部129、及形成於平板部129周圍之 此σ 0’掰片128之内部形成中空狀之厚壁部分。藉 二:片:本身之剛性得到保持,並且於為了使著色塑 夕女瓶110開封而握持辩片 128之變形。㈣掰片128之情況下,可抑制掰片 又’:圖11及圖12所示,於肩部m之藥液容納部 二夕卜周面及自跪弱部114起的藥液容納部m 側之樂液排出筒部112之外周面126上,具備分別突起於 97110774 47 200940046 藥液排出筒部112及藥液容納部ιη之外侧,且相互連接 之增強片131。 —如此,增強片131係以如下方式連續形成,即,跨於自 藥液排出筒部I12之脆弱部114起的藥液容納部1U側之 ^、與藥液容納部U1之肩部117之間,故可顯著提高 藥液容納部111與藥液排出筒部丨12間之剛性。 #藉此,例如於著色塑膠安瓿110之輸送中或操作中,自 藥液容納部111突起之藥液排出筒部i 12不易受損。 又,將掰片128掰裂而扭斷或折裂時,手指易於抓住增 強片131,且,具有準確停止旋轉之作用,故可容易且準 確地進行著色塑膠安瓿11〇之開封操作。 立曰強片131具有平板部132、及形成於平板部132周圍 之倒j部133,增強片131之内部形成中空狀之厚壁部 分。藉此,增強片131本身之剛性得到保持,進一步提高 增強效果,並且於為了使著色塑膠安親11〇開封而握持増 ❹強片131之情況下,可抑制增強片131之變形。且,扭轉 掰片128時,手指可良好地抓住增強片1 w ^ 於製造著色塑膠安瓿110時,掰片128及增強片131可 與藥液容納部U1、藥液排出筒部112及頂部113之各部 同時成形。 ° 著色塑膠安瓿110係例如可藉由將所謂吹塑填充密 :封法、與多層吹塑成形法進行組合之成形方法而製造。 /具體而言,例如,首先將上述熱塑性多層塑膠擠出成 形,而製作各層相互熔接積層之多層構造半成品。 97110774 48 20094004697110774 g Mouth name "ΤΙΝϋΠΝ (registered supplier methylphenol) benzotriazole (commercial name "TINUVIN (registered trademark) p" manufactured by Cibafin 37 200940046 Chemical Co., Ltd.), 2_(2'-base- 3',5'-bis(methylbenzyl)phenol)benzotriazole (trade name "TINUVIN (registrar's) 234" manufactured by Ciba Specialty Chemicals Co., Ltd.), 2 - (2'-hydroxyl ~3',5,-di-t-butylphenol)-5-chloro benzophenanal (trade name "TINUVIN (registered trademark) 327" manufactured by Ciba Specialty Chemicals Co., Ltd.), 2-(2, -Hydroxy-3,5,2-di-second-pentylbenzene-aged benzotriazole (trade name "TINUVIN (registered trademark) 328" manufactured by Ciba Specialty Chemicals Co., Ltd.), 2_(2, one A benzotriazole-based ultraviolet absorber such as hydroxy-5, _tetramethylbutylphenol) benzotriazole (trade name "TINUVIN (registered trademark) 329" manufactured by Ciba Specialty Chemicals Co., Ltd.). Further, for example, even if the drug contained in the colored plastic container is ozagrel sodium (specifically, 'aqueous solution, monomer, etc.), the ultraviolet absorber is preferably a benzotriazole system, and particularly preferably a product. Name "tinuvin (registered standard) 326". Further, various additives other than the pigment and the ultraviolet absorber may be blended in the colored layer as needed. For example, from the viewpoint of improving the efficiency of absorbing ultraviolet rays of the ultraviolet absorbing agent and reducing the amount of the ultraviolet absorbing agent used, it is possible to further contain an ultraviolet absorbing agent and metal oxide fine particles together. Examples of the metal oxide of the metal oxide fine particles include titanium oxide, zinc oxide, iron oxide, an oxidation sieve, and oxidized town. Further, the combination of the external absorbent and the metal oxide fine particles is not particularly limited. The above-mentioned trade name "ΤΙΝϋνΐΝ (registered trademark plus 6 97110774 38 200940046 and zinc oxide fine particles are preferably used. The inner layer is made of thermoplastic). Specifically, for example, as described above, for example, a polythene hydrocarbon layer, a ring-shaped thin smoke polymer layer, etc. may be mentioned. Examples of the polyene smoke of the olefin layer may be exemplified and formed. The coloring gel is the same. ❹ ❹ The cyclic olefin polymer forming the cyclic thin hydrocarbon polymer layer may, for example, be a copolymer of a cyclic olefin and an olefin, a ring-opening polycondensate of a cyclic olefin, or the like. Specifically, for example, a copolymer of ethylene and a cyclopentadiene, a ring-opening polymer of a berry and a pentane derivative, and a ring of two or more kinds thereof may be mentioned. Η: a biological ring-opening copolymer, or a hydride of the above. Among them, a nitride of a copolymer of ethylene and a compound of a sulphate compound, or a type or a mixture of two or more kinds of f pentadiene is preferable. Hydride of open-loop (co)polymer The straw is provided with an annular thin hydrocarbon polymer layer as an inner layer, which prevents the pigment or ultraviolet absorber in the colored layer from moving to the content of the colored plastic. Further, the mechanical strength or water-proof ability of the colored plastic container can be improved, or the coloring can be improved. The plastic container imparts air permeability. The glass transition temperature of the hydrocarbon polymer (5) is not particularly limited. For example, it is a power compensation differential scanning method by IIS K 71 21.1987 "Transfer temperature measurement method for plastics". The analyzer (power compensation ds〇 measured, intermediate point glass transfer temperature (Trag), preferably 6 65~8〇t: υ more preferably the right % olefin polymer Tg exceeds 8 (rc, then produces as follows Unsatisfactory situation 97110774 39 200940046 Condition: For example, in the case where the colored plastic container is an ampule as described below, a fine resin sheet called "burr" remains on the opening portion which is formed by splitting the ampule, or the force required for the split becomes On the other hand, if the '· Tg of the cyclic olefin polymer is less than 60 c ', there is a concern that the effect of preventing the movement of the pigment or the ultraviolet absorber in the colored layer or preventing The gas and water vapor permeation ability is lowered. The melt flow rate of the cyclic olefin polymer (舯趵 is not particularly limited, and is preferably 4 to 30 g/min in terms of the formability or mechanical properties of the colored plastic container. (26. (:). The molecular weight of the cyclic olefin polymer is not particularly limited, and the number average molecular weight <Mn> is preferably from 10,000 to 10,000, more preferably from 20,000 to 50,000. The molecular weight is determined, for example, by gel permeation chromatography (GPC) using cyclohexane as a solvent, and is obtained as a standard polystyrene equivalent value. The intermediate layer is a layer formed of a thermoplastic plastic. Specific examples thereof include: ❹ (a) a cyclic olefin polymer layer, (b) a cyclic olefin polymer layer ′, and one side surface and the other side surface of the cyclic olefin polymer layer, respectively. a laminated body of a three-layer structure in which one layer of a polyolefin layer of two layers is laminated, (c) a colored layer, and the like. * The cyclic olefin polymer forming the polyolefin layer or the cyclic olefin polymer layer forming the above polyolefin layer may be the same as described above. As shown in the above (a) and (b), even in the case where the cyclic olefin polymer layer is the intermediate layer of 97110774 40 200940046, the same effect as that of the inner layer of the annular smoky polymer layer can be obtained. . That is, it is possible to obtain an effect of preventing the pigment and the absorbing agent in the colored layer from moving to the inside of the colored plastic container, or the effect of the strength of the tirapus container, and further, the ability to prevent water: and gas from being transmitted can be obtained. Effect. In order to improve the adhesion of the system or to reduce the hard production of the colored plastic container, the polyethylene hydride may be appropriately formulated in the cyclic olefin polymer layer as the intermediate layer. ❹ ❹ 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为 为0. 935~〇. 9 B: Two' relative to 1〇. The content ratio of the polyethylene to the olefinic polymer layer in a part by weight is preferably 5 to 20 parts by weight. Further, in the colored layer, the intermediate layer forming the colored plastic container is selected as the plastic forming the colored layer or the pigment contained in the colored layer: the line absorbent and other additives, which are the same as described above. And, if necessary, for example, a layer such as the above thermoplastic multilayer plastic layer, a gas barrier layer, an oxygen absorbing layer, a sealing layer or the like. As the adhesive layer, the strong saturated carboxy group is compared with the ethylene-acrylic acid copolymer and the ethylene-acid: the layer of the moon. Further, as another example of the adhesive layer, for example, == polyethylene, in particular, a so-called layer such as a metallocene is used as a density. A polyethylene form = In the colored plastic container of the present invention, the thickness 1 of the colored layer can be set to 97110774 200940046 50~1 000. When the thickness T of the colored layer is less than 50 /zm, it is difficult to adjust a sufficient amount of the pigment or ultraviolet absorber required for exerting the effects of the present invention to the colored layer. On the other hand, if the thickness T of the colored layer exceeds 1 000 /zm, the thickness of the thermoplastic multilayered plastic as a whole becomes too large, so that the formability or workability of the colored plastic container is lowered. The thickness T of the colored layer is particularly preferably 50 to 4 Å in the above range, and more preferably 50 to 300. In particular, in the case where the colored plastic container is a colored plastic ampule, the thickness τ of the colored layer is preferably 5 〇 to 3 〇 () in m. In the colored plastic container of the present invention, the product P ratio (P% by weight) of the pigment in the colored layer and the product ρτ of the thickness τ (#m) of the colored layer are set to satisfy the following formula (1). 1 ^ PT^ 150--(1) ❹ 2 is set within the range of the above formula (1), and the ratio of the ultraviolet absorbing agent in the colored layer described below is ϋ (weight illusion, and The product UT of the thickness T(am) of the color layer is set to the following range, and the moderate visibility to the inside of the container can be maintained' and the wavelength light of the ultraviolet region is efficiently shielded. In contrast, the value of _PT < In the above range, the shielding effect of the wavelength light in the outer region is insufficient. On the contrary, if the value of ρτ exceeds the above range, it is difficult to confirm the inside of the colored plastic container. The value of ΡΤ is particularly preferably 5 to 12 in the above range. More preferably, it is 5 to (10). The relationship between the amount of the coloring agent in the layer and the thickness τ of the coloring layer: except that y is set to satisfy the range of the above formula (1), there is no special feature in the colored layer. From the viewpoint of dispersibility and the like, for example, in the colored layer, the content of the composition is preferably from 0. 〇1 to 〇 4% by weight. In the colored plastic container of the present invention, the ultraviolet absorbing agent in the colored layer is used. The content ratio U (% by weight) and the thickness T of the coloring layer ( The product υτ -· of /Zm) is set as follows: when the product ρ (% by weight) of the pigment in the colored layer and the product ΡΤ of the thickness T (#m) of the coloring layer exceed 20, the following formula (2) is satisfied. When the product pT is 2 〇 or less, the following formula (3) is satisfied. 5SUTS 160 (2) 20 < UTS 160 (3) 设定 By setting the value of the product τ to the above formula The range of (2) or (3), and setting the value of the above accumulation to the range of the above formula (1), maintains moderate visibility to the inside of the container, and can efficiently shield the wavelength light in the ultraviolet region. Here, if the value of the product UT is lower than the range of the above formula U) when the accumulation exceeds 20, or is less than the range of the above formula when the product is 2 〇 or less, the shielding effect of the wavelength light in the ultraviolet region is obtained. insufficient. On the other hand, if the value of UT exceeds the above range, there is a concern that the dispersibility of the ultraviolet absorber in the colored layer is lowered. In the case where the accumulation exceeds 20, the value of the accumulation τ is particularly preferably 5 to 120 Å or more preferably 10 to 1 于 in the above range. On the one hand, in the case where the accumulation is less than 20, the value of the accumulation is preferably from 30 to 160, more preferably from 35 to 16, in the above range. The relationship between the amount of the ultraviolet absorbing agent in the color layer and the thickness τ of the colored layer is not particularly limited as long as it is set to satisfy the range of the above formula (2), and is based on the dispersibility in the colored layer.重量重量。 01,0. 4重量%. Further, in the case where the side surface of the colored layer is the outer surface of the thermoplastic multilayer plastic, that is, the colored layer is a layer forming the outer layer of the colored plastic container, it is preferable to use the ultraviolet absorber in the colored layer. The quotient U/T when the content ratio ϋ (% by weight) is divided by the thickness T (/zm) of the colored layer is set to satisfy the following formula (4). U/TS 0· 004 (4) _ If the U/T exceeds the above range, there is a concern that the ultraviolet absorber oozes out from the colored layer to the outside of the colored plastic container. The value of the U/T is particularly preferably 〇·0038 or less, more preferably 〇.0001~〇.〇〇38. In the colored plastic container of the present invention, the thickness of each layer other than the colored layer is preferably set to be in the range of 10' with respect to the entire layer formed of the thermoplastic multilayer plastic. Further, the ratio of the thickness of each layer can be appropriately set depending on the type of the contents of the plastic container accommodated in the layer, the capacity, and the like. ❹ Thermoplastic, the thickness of the overall thickness of the multi-layer plastic, according to the use of the colored plastic container: the content type, the capacity of the contents of the glutinous rice, etc., may be appropriately set, and the value is not limited to, for example, preferably 300 to 1500 〃m, More preferably 400~1 WO #m. The pharmaceutical agent contained in the colored plastic container of the present invention is not particularly limited as long as it is preferably an aqueous solution of sodium ozagrel. For example, the shape of the color plastic container is not particularly limited, and examples include a cow writing bottle, a flexible bag container, and a bottle. Figure U is a front view of a color plastic container as an embodiment of a color plastic 97110774 44 200940046, and Fig. 12 is a side view thereof, and Fig. i3 is a plan view "Fig. 14 is a bottom view" Fig. 15 side Sectional view. As shown in Fig. 11 and Fig. 12, the colored plastic ampule 11 is provided with a liquid chemical storage portion lu for accommodating a chemical liquid in a bottomed cylindrical shape, and communicates with the open end (1)a of the chemical liquid storage portion m. The chemical liquid discharge cylinder portion 112 that extends sideways and the top portion (1) that closes one end portion of the chemical solution discharge cylinder portion 112; and the chemical liquid discharge cylinder portion 112 includes a weak portion 114 that is formed thin in the circumferential direction. In the chemical solution accommodating portion 111, a side end portion opposite to the bottom portion 116 is formed in the vicinity of the opening end 111a along the longitudinal direction of the central axis 115 of the chemical solution accommodating portion (1), and has a diameter from the bottom portion 116. The side surface toward the open end (1) "the shoulder portion m which becomes smaller (one side). = 3 and as shown in Fig. 14, the cross section of the chemical liquid storage portion lu is formed in a circular shape in a plan view or a bottom view, but the chemical liquid containing portion (1) The surface shape is not limited thereto, and may be formed, for example, in an elliptical shape. :: Referring to Fig. 11 and Fig. 12, the chemical liquid discharge cylinder portion 112 is continuous with the opening w11a of the chemical liquid storage portion lu as follows: Valley: The axis of the central axis 115 of the part (1) is the same as the central axis, and extends along the axis of the ς two-axis m. On one side of the drug discharge cylinder portion 112: the end ln f liquid discharges the tube portion 112' with the medicine The end portion of the liquid accommodating portion 111 on the side opposite to the side of the opening a) is discharged from the top 113 of the upper portion of the sealing liquid discharge portion 112. The side portion is continuous, and the forming portion == Μ is inserted, for example, to absorb the liquid medicine. In the case of a liquid injector nozzle, it is preferably as suitable as the above nozzle of 97110774 45 200940046 In order to fix the nozzle in a stable state, it is preferable to have a sufficient length between the chemical liquid accommodating portion ln and the top portion 113 in the axial direction of the chemical liquid discharge cylinder portion 112. The chemical liquid accommodating portion ill and the medicine The liquid discharge cylinder portion 112 and the top portion 113 are continuously integrated with each other, and a closed region for accommodating and sealing the chemical liquid is formed. Further, the chemical liquid discharge cylinder portion 112 is attached to the open end 111a of the chemical liquid storage portion 至 to the medicine. A substantially intermediate portion between the one end portions of the liquid discharge cylinder portion 112 is provided with a weak portion 114 (see FIG. 15) formed in a thin wall along the circumferential direction of the chemical discharge cylinder portion 112. Thereby, the liquid medicine is accommodated. The portion m and the top 113 side of the liquid discharging cylinder portion ι 2 are twisted or bent to each other, whereby the fragile portion (1) can be easily twisted, broken or split, and the colored plastic ampule 110 can be thereby obtained. In this case, the chemical liquid is discharged from the tubular portion 112, and the injection nozzle formed therein is inserted into a syringe nozzle (not shown) to collect the chemical liquid contained in the chemical storage unit U1. Furthermore, the syringe is manufactured in the same manner as: The injection needle is not attached to the front end of the mouth of the (4), and the nozzle is inserted into the opening σ of the drug discharge cylinder portion 112, thereby sucking the liquid medicine in the liquid medicine containing portion 111. As shown in Figs. 11 and 12 The chemical solution accommodating portion lu is provided on the outer peripheral surface thereof with a flange 124' which is located at a position opposite to the mandrel m of the chemical solution accommodating portion iu 2 and along the axis of the central axis 115: To: stretch, and from the chemical liquid volume (4) (1), the outer peripheral surface 123 is increased in the radial direction. The liquid chemical receiving portion ln is on the bottom portion 116 thereof, and the flange 125 is protruded outward from the bottom portion 116, The outer peripheral surface 123^ is convex 97110774 46 200940046 The flange 124 and the flange 125 of the bottom portion 116 are continuous with each other. In the case of 111, the flanges 124 and 125 are formed in the chemical solution accommodating portion and m is supplied to L + , whereby rigidity can be imparted to the chemical solution accommodating portion 111, and the shape of the chemical solution accommodating portion 111 can be maintained. As shown in FIG. 11 and FIG. 12, the liquid medicine discharge cylinder 112 is continuous from the top 113 side and protrudes from the chemical liquid discharge cylinder side and from the outer surface of the top 113. The fragile portion (1) of the portion 112 is formed continuously between the drug:::113 side and the top portion 113. Therefore, in the case where the grip portion ln and the top 113 side of the drug solution discharge tube portion 112 are turned or f-curved, the drug solution is accommodated. Part (1) and the liquid medicine ❹ The fragile part of the tube part m: The opening operation of the ampoules m is discharged from the cleavage liquid. The coloring is easily and accurately performed: the flat portion 129 and the σ 0' cymbal 128 formed around the flat portion 129 form a hollow thick portion. Borrowing two: piece: the rigidity of itself is maintained, and the deformation of the film 128 is held in order to open the colored plastic bottle 110. (4) In the case of the cymbal sheet 128, it is possible to suppress the cymbal sheet and the liquid chemical accommodating portion m from the chemical liquid accommodating portion of the shoulder portion m and the self-weak portion 114 as shown in Figs. 11 and 12 The outer peripheral surface 126 of the side liquid discharge cylinder portion 112 is provided with reinforcing sheets 131 which are respectively protruded from the outer side of the liquid medicine discharge cylinder portion 112 and the chemical liquid storage portion 119 of the 97110774 47 200940046. In this manner, the reinforcing sheet 131 is continuously formed in such a manner as to straddle the side of the liquid chemical containing portion 1U from the fragile portion 114 of the chemical liquid discharge cylindrical portion I12 and the shoulder portion 117 of the liquid chemical containing portion U1. Therefore, the rigidity between the chemical solution accommodating portion 111 and the drug solution discharge tube portion 12 can be remarkably improved. # Thereby, for example, during the conveyance or operation of the colored plastic ampule 110, the liquid medicine discharge cylinder portion i 12 protruding from the chemical liquid accommodating portion 111 is not easily damaged. Further, when the cymbal piece 128 is split and twisted or broken, the finger easily grasps the reinforcing piece 131, and has an effect of stopping the rotation accurately, so that the opening operation of the colored plastic ampule can be easily and accurately performed. The gusset sheet 131 has a flat plate portion 132 and an inverted j portion 133 formed around the flat plate portion 132, and the inside of the reinforcing sheet 131 is formed into a hollow thick portion. Thereby, the rigidity of the reinforcing sheet 131 itself is maintained, the reinforcing effect is further enhanced, and the deformation of the reinforcing sheet 131 can be suppressed in the case where the ytterbium sheet 131 is held in order to open the colored plastic enamel. Moreover, when the cymbal piece 128 is twisted, the finger can grasp the reinforcing piece 1 w ^ well. When the colored plastic ampule 110 is manufactured, the cymbal piece 128 and the reinforcing piece 131 can be combined with the chemical liquid accommodating portion U1, the medicinal liquid discharge tube portion 112, and the top portion. Each part of 113 is formed at the same time. ° The colored plastic ampule 110 can be produced, for example, by a so-called blow molding, a sealing method, or a multilayer blow molding method. Specifically, for example, the above thermoplastic multi-layered plastic is first extruded into a shape, and a multilayered semi-finished product in which the layers are welded to each other is produced. 97110774 48 200940046
即,將如下所述之熱塑性多層塑膠進行擠出成形,而製 作各層相互熔接積層之多層構造半成品,該熱塑性多層塑 膠係具備含有顏料及紫外線吸收劑之著色層,及直接^爽 持中間層而積層於上述著色層之一侧表面之内層,將上述 著色層之厚度T設定為50〜1000 /ζιη之範圍,上述著色 層中之顏料之含有比例p(重量%)、與上述著色層之厚度 T(Am)之積PT滿足下述式(1),上述著色層中之^外線= 收劑之含有比例U(重量%)、與上述著色層之厚度τ(_ 之積UT,於上述積pT超過20時滿足下述式(2),且,上 述積ΡΤ為20以下時滿足下述式(3)。 1 s PTS 150..· (1) 5$ UTS 160.·.⑵ 20< UTS 160..· (3) 納::;以!,莫夹持所得之多層半成品,形成藥液容 步驟)1 排出筒部112及增強片131之各部(吹塑 驟Γ,= 藥液容納部111之内部填充藥液(填充步 形成具備華:二,, 之封閉區域(密料驟)卜樂液排出筒部112及頂部113 著色塑膠钱(著色=^此、,可獲得填充㈣有藥液之 、有巴塑膠容器)110。 夕層構造半成σ 作。擠出機或模頭之:::塑成形中之常法而製 並無特別限定,_=、夕層構造半成品之成形條件等 可。 據夕層吹塑成形中之常法適當設定即 97110774 49 200940046 又’利用使用多層構造半成品之吹塑 造塑膠安瓿,除了半成 真充·岔封法製 出機數旦㈣n成層構&不同(形成半成品之擠 ▲丰成^ R構造不同)以外,可以與利用使用單層構 法製造塑膠安紙相同之方式來進:層: 者夕層薄膜之各層既可以上述之再 亦可於各#之P弓入丄,丄 々及β接而積層’ 互黏著述黏著性樹脂所形成之層而相 ❹L有效率地遮蔽紫外區域之光線自著色塑膠安瓿⑴ 2夕Μ入射至内部之觀點而言,著色塑膠安瓿11〇之藥液 容納部之厚度較佳為300〜1500 #m。 著色塑膠安瓶(著色塑膠容器)110可藉由各種方法而成 形。其中,較佳為可舉出:吹塑·填充·密封法。 本發明之著色塑膠容器,係藉由以特定範圍調配顏料及 紫外線吸收劑,而不會產生滲出等問題,並可賦予如下性 能:波長200〜380 nm之光線之透射率為5%以下,且波 ❹長600 nm之光線之透射率為40%以上。藉此,本發明之 塑膠安瓶例如可廣泛用於醫療用途,特別是適於容納光劣 化性藥劑、具體而言為奥紮格雷鈉水溶液等。 以上’就本發明之實施形悲加以說明,但本發明之實施 形態並不限定於此’於不改變本發明之宗旨之範圍内,可 : 對設計進行適當變形。 -[實施例] 繼而’根據實施例及比較例說明本發明,但本發明並不 受下述實施例限定。 97110774 50 200940046 (塑膠安親之製造及開封性評價) [實施例1 -1〜1 - 6及比較例1 _ 1〜卜2 j (1)塑膠安瓿之製造 多層薄膜之形成材料,係如下所示。 C0C1 :環狀稀烴共聚物(乙烯/四環十二_巧物), 玻璃轉移溫度(Tg)為70。〇,三井化學股份有限公、司製造, 商品名「APEL(註冊商標)APL8008T」 》C0C2 ··環狀烯烴共聚物(乙烯/四環十二烯系共聚物), Tg為80°C,三井化學股份有限公司製造,商品*「ApEL(註 冊商標)APL6509T」 C0C3 :環狀烯烴共聚物(乙烯/四環十二烯系共聚物), Tg為105°C,三井化學股份有限公司製造,商品名 「APEL(註冊商標)APL6011T」 C0P1 :環狀烯烴聚合物(降萡烯系開環聚合物之氫化 物),Tg為70 c,日本瑞翁股份有限公司製造,商品名 | 「ZE0N0R(註冊商標)750R」 C0P2,環狀烯烴聚合物(降萡烯系開環聚合物之氫化 物)’ Tg為102C ’日本瑞翁股份有限公司製造,商品名 「ZE0N0R(註冊商標)1020R」 PE1 .尚壓法低密度聚乙烯,密度為〇. 928 g/cm3,宇部 丸善聚乙烯(Ube Maruzen Polyethylene)股份有限公司製 造,商品名「UBE POLYETHYLENE(註冊商標)B128H」 PE2:於PE1中調配紫外線吸收劑(2-(2,_經基-3’-第三 丁基-5’ -曱基苯酚)-5-氯苯并***’汽巴精化股份有限公 97110774 51 200940046 司製造,商品名「TINUVIN(註冊商標)326」)與氧化鋅微 粒子(平均粒徑為30 μ m),設定上述紫外線吸收劑之含 有比例為0· 218重量%,調整上述氧化鋅微粒子之含有比 例為0· 182重量%者。 PE3 :於PE1中調配紫外線吸收劑(商品名r CIBA TINUVIN(註冊商標)326」),設定上述紫外線吸收劑之含 有比例為0. 24重量%者。That is, the thermoplastic multilayer plastic described below is extrusion-molded to produce a multilayered semi-finished product in which the layers are welded to each other, the thermoplastic multilayer plastic having a coloring layer containing a pigment and an ultraviolet absorber, and directly holding the intermediate layer. The inner layer of one side surface of the colored layer is laminated, and the thickness T of the colored layer is set to be in the range of 50 to 1000 /ζη, and the content ratio of the pigment in the colored layer is p (% by weight) and the thickness of the colored layer. The product PT of T(Am) satisfies the following formula (1), and the outer line in the colored layer = the content ratio U (% by weight) of the collector, and the thickness τ of the colored layer (the product UT of _, in the above product When pT exceeds 20, the following formula (2) is satisfied, and when the above-mentioned accumulation is 20 or less, the following formula (3) is satisfied. 1 s PTS 150..· (1) 5$ UTS 160.·.(2) 20< UTS 160..· (3) Na::; to !, Mo holding the obtained multi-layer semi-finished product to form a liquid preparation step) 1 Discharging each part of the cylindrical portion 112 and the reinforcing sheet 131 (Blowing, 药 液 液111 internal filling liquid (filling step formation with Hua: two,, closed area (closed material) ) Bu Le liquid discharge tube portion 112 and top 113 color plastic money (coloring = ^,, can be filled (four) with liquid medicine, with a plastic container) 110. The layer structure is half into σ. Extruder or mold Head::: The usual method in plastic molding is not particularly limited, and _=, the molding conditions of the semi-finished structure of the eve layer structure, etc. can be appropriately set according to the usual method in the eve layer blow molding, that is, 97110774 49 200940046 The use of multi-layer construction of semi-finished products to blow plastic ampoules, in addition to the semi-finished 岔 岔 法 法 制 数 ( 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四 四The construction method of plastic paper is the same way: Layer: The layers of the film can be used for the above-mentioned ones, or the P-bends of each of them can be laminated, and the layers can be laminated with the same layer of 'adhesive resin'. The layer formed is effective to shield the light in the ultraviolet region from the viewpoint of the colored plastic ampule (1) 2 Μ Μ incident to the inside, the thickness of the liquid accommodating portion of the colored plastic ampule 11 is preferably 300 to 1500 #m Colored plastic ampoules ( The colored plastic container 110 can be formed by various methods. Among them, a blow molding, filling, and sealing method is preferable. The colored plastic container of the present invention is prepared by blending a pigment and an ultraviolet absorber in a specific range. There is no problem such as bleeding, and the following properties can be imparted: the transmittance of light having a wavelength of 200 to 380 nm is 5% or less, and the transmittance of light having a wavelength of 600 nm is 40% or more. The plastic ampoule can be widely used, for example, for medical purposes, and is particularly suitable for containing a photo-deteriorating agent, specifically an aqueous solution of sodium ozagrel. The present invention has been described with respect to the embodiments of the present invention. However, the embodiments of the present invention are not limited thereto, and the design may be appropriately modified without departing from the scope of the invention. - [Examples] The present invention will now be described based on examples and comparative examples, but the present invention is not limited by the following examples. 97110774 50 200940046 (Manufacturing and opening evaluation of plastic security) [Examples 1 -1 to 1 - 6 and Comparative Example 1 _ 1 to 2 2 (1) The material for forming a multilayer film of plastic ampoules is as follows Show. C0C1: a cyclic dilute hydrocarbon copolymer (ethylene/tetracyclotetradecene) having a glass transition temperature (Tg) of 70. 〇, manufactured by Mitsui Chemicals Co., Ltd., trade name "APEL (registered trademark) APL8008T" "C0C2 · · cyclic olefin copolymer (ethylene / tetracyclododecene copolymer), Tg 80 ° C, Mitsui Manufactured by Chemical Co., Ltd., product * "ApEL (registered trademark) APL6509T" C0C3: a cyclic olefin copolymer (ethylene/tetracyclododecene copolymer), Tg is 105 ° C, manufactured by Mitsui Chemicals Co., Ltd., "APEL (registered trademark) APL6011T" C0P1: a cyclic olefin polymer (hydride of a decene-based ring-opening polymer), Tg 70 c, manufactured by Nippon Zeon Co., Ltd., trade name | "ZE0N0R (registered) Trademark) 750R" C0P2, cyclic olefin polymer (hydride of decene-based ring-opening polymer) 'Tg is 102C 'Manufactured by Nippon Zeon Co., Ltd., trade name "ZE0N0R (registered trademark) 1020R" PE1 . Pressurized low-density polyethylene, density 〇. 928 g/cm3, manufactured by Ube Maruzen Polyethylene Co., Ltd., trade name "UBE POLYETHYLENE (registered trademark) B128H" PE2: UV-dispensed in PE1 Absorbent (2-(2,_carbyl-3'-t-butyl-5'-nonylphenol)-5-chlorobenzotriazole' Ciba Specialty Chemicals Co., Ltd. 97110774 51 200940046 Manufactured, commodity The name "TINUVIN (registered trademark) 326") and the zinc oxide fine particles (average particle diameter: 30 μm), the content ratio of the ultraviolet absorber is set to 0. 218% by weight, and the content ratio of the zinc oxide fine particles is adjusted to be 0. 182% by weight.重量重量。 The PE1 is a UV absorber (trade name r CIBA TINUVIN (registered trademark) 326), the proportion of the above-mentioned ultraviolet absorber is set to 0. 24% by weight.
❹ PE4 :高密度聚乙烯’密度為〇. 94〇 g/cm3,普瑞曼聚合 物(Prune P〇lymer)股份有限公司製造,商品名 「ULT-ZEX(註冊商標)Uz4020B」 PE5:高密度聚乙烯,密度為〇.965 g/cm3,普瑞曼聚合 物股份有限公司製造,商品名「ΝΕ〇_ΖΕχ(註冊商 標)Νζ65150Β」 ΡΕ6.藉由二茂金屬系觸媒而聚合之直鏈狀低密度聚乙 烯,岔度為0.903 g/cm3 ’普瑞曼聚合物股份有限公司製 造,商品名「Evolue(註冊商標)sp5〇1〇B」 [實施例1-1] 藉由吹塑·填充·冑封法,而製造ffil 1〜圖7所示之形 狀的容納量為2· 5 mL用之塑膠安瓶。再者,於塑膠安瓶 内,填充及密封2.5 mL之生理鹽水。 又於形成塑膠安瓶時,使用ζ恳接、生 厚度為640㈣),亨5層2用5層構造之多層塑膠(總 , 5層構造之多層塑膠係具備:由PE2 所形成之外層20(厚度Λ 9ηη 、 "* ” 又马200 Mm),形成於外層20之一 側表面且由ΡΕβ所再彡# > i 成之黏著層22(厚度為20 #m),積 97110774 52 200940046 層於外層20之黏著層22側且由COCUTU 70。〇所形成 之中間層18(厚度為200心),形成於中間層18之與外 層20之積層面的相反侧表面且由觸所形成之黏著層 、21(厚度為2〇 ")’以及積層於中間層18之黏著層a 侧且由PE1所形成之内層19(厚度為2〇〇 ")。再者,多 層塑?之總厚度及各層(中間層18、内層19、外層20、 各黏著層21、22)之厚度,表示塑膠安瓶1〇之藥液容納 —β η之厚度(以下,相同)。 [實施例1-2] 使用由C0C2(Tg為80°C)所形成之層(厚度為200 代替由coci所形成之層,來作為中間層18,除此以外, 以與實施例1 一1相同之方式,製造填充及密封有生理鹽水 之塑膠安瓿。 [實施例1-3] 使用由PE3所形成之層(厚度為2〇〇以…代替由pE2所 ❿形成之層,來作為外層2〇,並使用由c〇pi(Tg為7〇它) 所形成之層(厚度為2〇〇代替由c〇ci所形成之層, 來作為中間層18 ’除此以外’以與實施例卜1相同之方 式製&填充及达、封有生理鹽水之塑膠安親。 [實施例1-4] 使用由以3 : 1(重量比)之比例混合COClCTg為7(TC ) .與PE4之混合樹脂所形成之層(厚度為200 am),代替由 所形成之層’來作為中間们8,除此以外,以與實 知例1 1才目同之方式’製造填充及冑封有生理鹽水之塑膠 97110774 53 200940046 安瓿。 [實施例1-5] 使用由以3 . wθ 與哪之混合樹^置比)之比例混合C〇PKTg為歡) con所形成^戶1形成之層(厚度為200 口),代替由 θ 朿作為中間層18 ’除此以外,以盎實 施例1-1相同之大斗、 ^、貝 ^ _ 式’裒造填充及密封有生理鹽水之塑膠 女额1 ° / ❹ ❹ [實施例1-6] 使用由以19 : K i θ Q重ι比)之比例混合C0Pl(Tg為7〇。〇 ,、E之〜合樹脂所形成之層(厚度為2〇〇 ,抑转士 C0C1所形成之斧,上厚度為200 ""°代替由 θ來作為中間層18,除此以外,以與實 施例1 -1相同之方式,制、 安哎。 真充及密封有生理鹽水之塑膠 [比較例1-1] 代替由C0C:r:(J“ 1〇5C)所形成之層(厚度為2°0 ") 二之層’來作為中間層18,除此以外, 以與實細例1 -1相同之方戎,止 之塑膠安瓿。 Ik填充及密封有生理鹽水 [比較例1-2] 使用由c〇P2(Tg為102t)所形成之 代替由C0C1所形成之層,來:(厚度為200 1 1 r, 术作為中間層18,除此以外, 以與實鈀例1 -1相同之方式,剪 之塑膠安瓿。 製k填充及密封有生理鹽水 塑膠 將實施例Η〜Η及比較例Η〜"中所製造之 97110774 200940046 ❹ 安瓶之層構成示於表1。 [表1 ] 外層20 黏著層22 中間層18 黏著層21 内層19 總厚度(ym) 實施例1-1 PE2 200 PE6 20 /zm COC1 200 PE6 20 /zm PEI 200 //m 640 實施例1-2 實施例1-3 PE2 200 //m …丽—_ 200 β\Ά PE6 20 …ϋ…… 20 /zm C0C2 200 Aim C0P1 200 PE6 20 PE6 20 μ.\Ά PEI 200 //m …-…- 200 640 640 實施例1-4 ΡΕ2 200 PE6 20 β\& C0C1+PE4 (3:1) 200 PE6 20 PEI 200 640 實施例1-5 PE2 200 //m PE6 20 /zm C0P1+PE5 (3:1) 200 PE6 20扉 PEI 200扉 640 實施例卜6 PE2 200 /zm PE6 20 /zm C0P1+PE1 (19: 1) 200 PE6 20 /zm PEI 200 鲁♦嫌售·畤勢鲁— 640 比較例1_1 PE2 PE6 C0C3 PE6 PEI 比較例1-2 -纠-复. PE6 麗-l. PE1 " _200 ㈣ 640 .2p〇..^m ... 20 /zm 200 PE2 PE6 C0P2 200 //m 20 2ΠΠ nm (2)塑膠安瓿之開封性評價 20 am 640 ❹ 對於實施例1-1〜1-6及比較例丨—丨〜丨_2中所製造之 充及密封有生理鹽水的塑膠安瓶1〇,用夾 納部11之—對增強片31,用夹具握持藥液排出筒部Γ2 之掰片28後,以樂液容納部藥液排 心轴15為旋轉轴,旋轉掰片28,扭斷具 :: 液排出筒部12之頂部13側,從而開封塑膠8之樂 此處,使用旋轉扭矩計,測定扭斷 〇。 排出筒部12之頂部13側所裳 町月28之藥液 於表2。 斤而之力(N.m)。將測定結果示 又,開封後’於連接於藥液 ⑽11侧之藥液排出筒 97110774 55 200940046 12之開口,***用以吸取藥液容納部I〗内之生理鹽水 之注射器喷嘴,繼而,將藥液容納部11以藥液排出筒部 12之開口向下之狀態放置’觀察有無產生來自上述開口 之漏液。將其結果示於表2。 [表2] 需i力每單位厚斤需之力一 ---LN · m ]__[ N · m/mm 1 有無漏液 ❹ --^~~ --t.3MJ.-2...... "〇:4〇...............................o'1-o..............................f-…… '''·〇:35..................-............〇Λ55................-............―― …Γ'1:28"'………-----------.……〇Λ44 ...................—?---…- i^JLX-6 .一;〇:32........................................-....................―― —---— 比較例1-1 --- 比較例1-2 …………-…… ❹ 根據表2可明確,實施 ,’雖中間層18之厚度均相對較大,但相對於藥液排出 同部12之多層塑膠之厚度,可將塑膠安瓿1〇之開封 ***脆弱部14)所f之力’設定為065 下之小 值。又,開封後,並未觀察到來自藥液排 口與注射器喷嘴間之漏液。 门丨U之開 =對於此,於形成中間層18所使用之環狀烯烴系(共) 物之玻璃轉移溫度超過⑽〜啊之範圍的比較例 卜2中’相對於藥液排出筒部12之多層塑膠 =開封塑膠安瓶i。所需之力超過Ο.,—::厚 觀察到來自上述開口之漏液。 [實施例1-7〜1-9] (1)塑膠安瓿之製造 97110774 56 200940046 塑膠安瓿(多層薄臈)之 與實施例l+H中所糾/才4如下所示。再者,對 PP1·臂⑽ 相同者進行省略。 名「娜 瑞曼聚合物股份有限公司製造,商品 ❹ TPi^ . : a司製造,商品名「TAFMER(註冊商標)XM7070」 —2性彈性體(奈米結晶構造控制型聚丙烯彈性 _ 彳化干股份有限公司製造,商品名「Ν〇τ 商標)PN-3050」 E3熱塑性彈性體(奈米結晶構造控制型聚丙烯彈性 體)一井化學股份有限公司製造,商品名「N〇TI〇(註冊 商標)ΡΝ-2070」 ΤΡΕ4 .熱塑性彈性體(聚乙烯系彈性體),三井化學股份 有限公司製造,商品名「TAFMER(註冊商標)Α0585Χ」 [實施例1-7] ❹ 藉由吹塑.填充·密封法,而製造圖1〜圖7所示之形 狀的容納量為2. 5 mL用之塑膠安瓿。再者,於塑膠安瓿 内’填充及密封2. 5 mL之生理鹽水。 於形成塑膠安瓿時,使用5層構造之多層塑膠(總厚度 為520 # m),該5層構造之多層塑膠係具備:由以3 : 2(重 • 量比)之比例混合PP1與TPE2之混合樹脂'所形成之外層 '20(厚度為150 em),形成於外層20之一側表面且由以 1 : 1 (重量比)之比例混合PE6與TPE4之混合樹脂所形成 之黏著層22(厚度為1〇 /zm),積層於外層20之黏著層 97110774 57 200940046 22侧且由c〇Pl(Tg為70。〇所形成之中間層18(厚度為 2〇〇 β m) ’形成於中間層18之與外層20之積層面的相反 侧表面、且由以1 : 1 (重量比)之比例混合pE6與TPE4之 ·· 混合樹脂所形成之黏著層21(厚度為1〇 um),以及積層 、 於中間層18之黏著層21側且由以3 : 2(重量比)之比例 混合PP1與TPE2之混合樹脂所形成之内層ι9(厚度為15〇 //m)。相對於混合樹脂整體,而於上述混合樹脂中,以 ❹ 0_2重量%之比例調配成核劑(2,2,-亞甲雙(4,6-二_第三 丁基苯酚)磷酸鈉,ADEKA股份有限公司製造,品名 厂 Adekastab NA-11」)° [實施例1-8] 为別使用由以4 : 1 (重量比)之比例混合pp 1與之 混合樹脂所形成之層(厚度為15〇以…,代替由含有ρρι 及TPE2之混合樹脂所形成之層,作為外層2〇及内層i9, 除此以外’以與實施例卜7相同之方式製造填充及密封 ❹有生理鹽水之塑膠安瓿。 [實施例1-9] 分別使用由以9 : 1 (重量比)之比例混合ρρι盥τρΕι之 混合樹脂所形成之層(厚度為15〇 Mm)’代替由含有ρρι 及TPE2之混合樹脂所形成之層,來作為外層2q及内層 19,除此以外,以與實_卜7彳目同之方式,製造填充及 密封有生理鹽水之塑膠安瓿。 將實施例1 - 7〜1 - 9中所贺;I夕袖咖 主Q 甲所“之塑膠安瓿之層構成示於 表<3 0 97110774 58 200940046 [表3 ] 外層20 黏著層22 中間層18 黏著層21 内層19 總厚度(/zm) 實施例1-7 PP1+TPE2 (3:2) 150 ym PE6+TPE4 (1:1) 10 C0P1 200 PE6+TPE4 (1:1) 10 /zm PP1+TPE2 (3:2) 150 β\Ά 520 實施例1-8 PP1+TPE3 (4:1) 150 β\Ά PE6+TPE4 (1:1) 10 C0P1 200 /zm PE6+TPE4 (1:1) 10 /zm PP1+TPE3 (4:1) 150 /zm 520 ΡΡ1+ΤΡΕ1 PE6+TPE4 C0P1 200 //m PE6+TPE4 PP1+TPE1 實施例1-9 (9:1) 150 /zm (1:1) 10 /zm (1:1) 10 em (9:1) 150 520 (2)塑膠安瓿之開封性評價 對實施例1-7〜1-9中所製造之填充及密封有生理鹽水 之塑膠安瓿,進行與上述相同之開封性評價。其結果,於 實施例1 -7〜1 -9之任一例中,均可將塑膠安瓶1 〇之開封 (***脆弱部14)所需之力,設定為0.40 N.m以下(相對 於藥液排出筒部12之多層塑膠之厚度,為0.65 N.m/mm 以下)之小值。又,開封後,亦未觀察到來自藥液排出筒 部12之開口與注射器喷嘴間之漏液。 (著色塑膠安瓶之製造及物性評價) ❹ 下述實施例2-1〜2-54及比較例2〜1〜2-19中所使用之 樹脂材料、顏料及紫外線吸收劑,如下所述。 PE1 :高壓法低密度聚乙烯,密度為〇 928 g/cm3,宇部 丸善聚乙烯股份有限公司製造,商品名r Ube POLYETHYLENE(註冊商標)B128H」 PE4:高密度聚乙埽,密度為〇.94〇 g/cm3,普瑞曼聚合 •物股份有限公司製造,商品名「ULT-ZEX(註冊商 標)Uz4020B」 PE5 :高密度聚乙稀,密度為〇· 965 g/cm3,普瑞曼聚合 97110774 59 200940046 物股份有限公司製造,商品名「ΝΕ〇_ΖΕχ(註冊商 標)Νζ65150Β」 ΡΕ7 .黏著性低密度聚乙烯,密度為〇. 9〇3 ,普瑞 ·曼聚合物股份有限公司製造,商品名「Εν—(註冊商 標)SP0510B」 PP1 :聚丙烯,普瑞曼聚合物股份有限公司製造,商品 名「B205」 PP2:聚烯烴系熱塑性彈性體,三井化學股份有限公司 製造,商品名「ΝΟΤΙΟ(註冊商標)pN_3〇5〇」,與上述τρΕ2 相同。 ΡΡ3:聚烯烴系熱塑性彈性體,三井化學股份有限公司 製造,商品名「TAFMER(註冊商標)χΜ7〇7〇」,與上述τρΕΐ 相同。 C0C1 ·•環狀烯烴共聚物(乙烯/四環十二烯系共聚物),❹ PE4: High-density polyethylene 'density is 〇. 94〇g/cm3, manufactured by Prune P〇lymer Co., Ltd., trade name "ULT-ZEX (registered trademark) Uz4020B" PE5: high density Polyethylene, density 〇.965 g/cm3, manufactured by Prehman Polymer Co., Ltd., trade name "ΝΕ〇_ΖΕχ(registered trademark) Νζ65150Β" ΡΕ6. Linear chain polymerized by a metallocene catalyst Low density polyethylene with a twist of 0.903 g/cm3 'Manufactured by Preman Polymer Co., Ltd., trade name "Evolue (registered trademark) sp5〇1〇B" [Example 1-1] by blow molding The filling and sealing method is used to manufacture a plastic ampoule for the shape of the ffil 1 to the shape shown in Fig. 7 of 2.5 mL. Furthermore, in a plastic ampoule, 2.5 mL of physiological saline was filled and sealed. In the formation of plastic ampoules, the use of splicing, raw thickness of 640 (four)), Heng 5 layer 2 with a 5-layer structure of multi-layer plastic (total, 5-layer structure of the multi-layer plastic system: the outer layer 20 formed by PE2 ( The thickness Λ 9ηη , "* ” and the horse 200 Mm) are formed on one side surface of the outer layer 20 and are further 彡β 彡# > i into the adhesive layer 22 (thickness 20 #m), product 97110774 52 200940046 layer An intermediate layer 18 (having a thickness of 200 hearts) formed on the adhesive layer 22 side of the outer layer 20 and formed by COCUTU 70. is formed on the opposite side surface of the intermediate layer 18 from the layer of the outer layer 20 and is adhered by the contact. a layer, 21 (thickness of 2 〇 ")', and an inner layer 19 (thickness of 2 〇〇") laminated on the adhesive layer a side of the intermediate layer 18 and formed of PE1. Further, the total thickness of the multilayer plastic The thickness of each layer (the intermediate layer 18, the inner layer 19, the outer layer 20, and the adhesive layers 21 and 22) indicates the thickness of the chemical liquid containing the plastic ampule - β η (hereinafter, the same). [Example 1-2 Using a layer formed of C0C2 (Tg of 80 ° C) (thickness of 200 instead of the layer formed by coci) as the intermediate layer 18, except A plastic ampule filled and sealed with physiological saline was produced in the same manner as in Example 1 to 1. [Example 1-3] A layer formed of PE3 (thickness of 2 〇〇 was replaced by pE2) The layer formed by tantalum is used as the outer layer 2〇, and a layer formed by c〇pi (Tg is 7〇) is used (the thickness is 2〇〇 instead of the layer formed by c〇ci, as the intermediate layer 18' Other than the above, 'plasticized and filled with plastic saline filled and sealed in the same manner as in Example 1. [Example 1-4] Mixing COClCTg in a ratio of 3:1 (weight ratio) It is a layer formed of a mixed resin of 7 (TC) and PE4 (thickness: 200 am), instead of the layer formed by the layer 8 as the intermediate member 8, except that it is the same as the practical example 1 1 The method of 'manufacturing filled and sealed plastic with plastic saline 97110774 53 200940046 ampoule. [Example 1-5] Mixing C〇PKTg with a ratio of 3 . wθ to which mixed tree is used) Forming a layer formed by the household 1 (thickness of 200) instead of θ 朿 as the intermediate layer 18' Example 1-1 the same big bucket, ^, shell ^ _ type '裒 填充 填充 及 及 及 及 塑胶 塑胶 塑胶 塑胶 塑胶 ❹ ❹ 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 实施 ❹ ❹ The ratio of ι to) is mixed with C0Pl (Tg is 7 〇. 〇, E ~ 至 树脂 resin layer (thickness is 2 〇〇, the axe formed by S0C1, the upper thickness is 200 "" In the same manner as in Example 1-1, θ was used as the intermediate layer 18, and ampoules were prepared in the same manner as in Example 1-1. Plastic filled with normal saline and sealed [Comparative Example 1-1] Instead of the layer formed by C0C:r:(J"1〇5C) (thickness 2°0 ") 18, other than this, in the same way as the actual example 1-1, the plastic ampule is stopped. Ik is filled and sealed with physiological saline [Comparative Example 1-2] The use of c〇P2 (Tg is 102t) Instead of the layer formed by C0C1, (the thickness is 200 1 1 r, the operation is as the intermediate layer 18, except that the plastic ampule is cut in the same manner as the real palladium case 1-1. Sealed with saline plastics. The layer composition of the 97110774 200940046 ❹ 瓶 bottle made in Example Η Η Η & & & & & & & & & & [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ [ Inner layer 19 Total thickness (ym) Example 1-1 PE2 200 PE6 20 /zm COC1 200 PE6 20 /zm PEI 200 //m 640 Example 1-2 Example 1-3 PE2 200 //m ...Li-_ 200 β\Ά PE6 20 ...ϋ... 20 /zm C0C2 200 Aim C0P1 200 PE6 20 PE6 20 μ.\Ά PEI 200 //m ...-...- 200 640 640 Example 1-4 ΡΕ2 200 PE6 20 β\& C0C1+PE4 (3:1) 20 0 PE6 20 PEI 200 640 Example 1-5 PE2 200 //m PE6 20 /zm C0P1+PE5 (3:1) 200 PE6 20扉PEI 200扉640 Example b PE2 200 /zm PE6 20 /zm C0P1+ PE1 (19: 1) 200 PE6 20 /zm PEI 200 Lu ♦ Suspected 畤 鲁 — - 640 Comparative Example 1_1 PE2 PE6 C0C3 PE6 PEI Comparative Example 1-2 - Correction - Complex. PE6 Li-l. PE1 " _200 (4) 640 .2p〇..^m ... 20 /zm 200 PE2 PE6 C0P2 200 //m 20 2ΠΠ nm (2) Evaluation of the opening of plastic ampoules 20 am 640 ❹ For Examples 1-1 to 1-6 and In the comparative example 丨 丨 丨 丨 中 塑胶 塑胶 塑胶 丨 丨 丨 丨 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶 塑胶After the sheet 28, the liquid liquid accommodating portion of the liquid accommodating portion is used as a rotating shaft, and the cymbal piece 28 is rotated. The twisting device is: the liquid discharges the top portion 13 of the cylindrical portion 12, thereby opening the plastic 8 and using the rotation. Torque meter, measuring the twist 〇. The liquid medicine of the top of the discharge tube portion 12 on the side of the top 13 is shown in Table 2. The force of force (N.m). The result of the measurement is shown, after the opening, the opening of the liquid medicine discharge cylinder 97110774 55 200940046 12 connected to the side of the liquid medicine (10) 11 is inserted into the syringe nozzle for sucking the physiological saline in the liquid medicine receiving portion I, and then the medicine is taken The liquid accommodating portion 11 is placed in a state where the opening of the chemical liquid discharge cylinder portion 12 is downwardly viewed to see whether or not liquid leakage from the opening is generated. The results are shown in Table 2. [Table 2] The force required for each unit of thick force is one---LN · m ]__[ N · m/mm 1 with or without liquid leakage --^~~ --t.3MJ.-2... ... "〇:4〇..............................o'1-o..... .........................f-... '''·〇:35.............. ....-............〇Λ55................-............- ...Γ'1:28"'.........-----------.......〇Λ44 ...................—?-- -...- i^JLX-6 . One; 〇: 32.................................... ....-....................————---Comparative Example 1-1 --- Comparative Example 1-2 ............- ...... According to Table 2, it can be clearly stated that, although the thickness of the intermediate layer 18 is relatively large, the plastic ampules can be opened and the fragile portion 14 can be opened relative to the thickness of the multilayer plastic which is discharged from the same portion 12 of the liquid medicine. The force of 'f' is set to a small value of 065. Further, after the opening, no leakage from the liquid discharge port and the nozzle of the syringe was observed. In the case of the comparative example 2 in which the glass transition temperature of the cyclic olefin system (co) used in forming the intermediate layer 18 exceeds the range of (10) to ah, the liquid discharge cylinder portion 12 is Multi-layer plastic = Kaifeng plastic ampoule i. The force required exceeds Ο.,—:: Thickness The leakage from the above opening is observed. [Examples 1-7 to 1-9] (1) Manufacture of plastic ampoules 97110774 56 200940046 Plastic ampules (multilayer slabs) and the entanglements in the embodiment l+H are as follows. In addition, the same as the PP1·arm (10) is omitted. "Noruiman Polymer Co., Ltd., product ❹ TPi^ . : manufactured by A Division, trade name "TAFMER (registered trademark) XM7070" - 2 elastomers (nano crystal structure control type polypropylene elasticity _ 彳Manufactured by Dry Co., Ltd., trade name "Ν〇τ trademark" PN-3050" E3 thermoplastic elastomer (nano crystal structure control type polypropylene elastomer) manufactured by Ishii Chemical Co., Ltd., trade name "N〇TI〇( Registered trademark) ΡΝ-2070" ΤΡΕ4. Thermoplastic elastomer (polyethylene elastomer), manufactured by Mitsui Chemicals Co., Ltd., trade name "TAFMER (registered trademark) Α0585Χ" [Example 1-7] 藉 By blow molding. 5毫升的塑料瓿。 The filling and sealing method, and the shape of the shape shown in Figure 1 to Figure 7 is 2. 5 mL of plastic ampoules. Furthermore, in the plastic ampule, the filling and sealing of 2.5 mL of physiological saline. In the formation of plastic ampoules, a multi-layer plastic with a 5-layer structure (total thickness 520 # m) is used. The multi-layer plastic system of the 5-layer structure has a mixture of PP1 and TPE2 in a ratio of 3:2 (weight-to-weight ratio). The outer layer '20 (having a thickness of 150 em) formed of the mixed resin' is formed on one side surface of the outer layer 20 and is an adhesive layer 22 formed by mixing a mixed resin of PE6 and TPE 4 in a ratio of 1:1 (weight ratio) ( The thickness is 1 〇 / zm), laminated on the adhesive layer of the outer layer 20 97110774 57 200940046 22 side and formed by c〇Pl (Tg is 70. The intermediate layer 18 (thickness is 2〇〇β m) formed by ' An adhesive layer 21 (thickness of 1 μm) formed by mixing the opposite side surfaces of the layer 18 with the outer layer 20 and mixing the mixed resin of pE6 and TPE4 in a ratio of 1:1 (weight ratio), and The inner layer ι9 (thickness 15 Å/m) formed by laminating the mixed layer of PP1 and TPE 2 at a ratio of 3:2 (weight ratio) on the side of the adhesive layer 21 of the intermediate layer 18 is integrated with the mixed resin as a whole. In the above mixed resin, the nucleating agent (2,2,-methylene double (4,6-di_) is formulated in a ratio of ❹ 0-2% by weight. Tributylphenol) sodium phosphate, manufactured by ADEKA Co., Ltd., product name Adekastab NA-11") [Examples 1-8] Mixed with pp 1 in a ratio of 4:1 (by weight) for mixing A layer formed of a resin (having a thickness of 15 Å instead of a layer formed of a mixed resin containing ρρι and TPE 2 as an outer layer 2 〇 and an inner layer i9, except that a filling was performed in the same manner as in Example 7) And sealing the plastic ampoule with physiological saline. [Examples 1-9] Instead of using a layer (thickness 15 〇 Mm) formed by mixing a mixed resin of ρρι盥τρΕι in a ratio of 9:1 (weight ratio) A plastic ampule filled and sealed with physiological saline is produced in the same manner as in the case of the outer layer 2q and the inner layer 19, and the layer formed of the mixed resin of ρρι and TPE2 is used. Example 1 - 7~1 - 9 congratulations; I eve sleeve coffee main Q A "The composition of the plastic ampules is shown in the table <3 0 97110774 58 200940046 [Table 3] Outer layer 20 Adhesive layer 22 Middle layer 18 Adhesive Layer 21 Inner Layer 19 Total Thickness (/zm) Example 1-7 PP1+TPE2 (3:2) 150 ym PE6+TPE4 (1:1) 10 C0P1 200 PE6+TPE4 (1:1) 10 /zm PP1+TPE2 (3:2) 150 β\Ά 520 Example 1-8 PP1+TPE3 (4:1) 150 β\Ά PE6+TPE4 (1:1) 10 C0P1 200 /zm PE6+TPE4 (1:1) 10 /zm PP1+TPE3 (4:1) 150 /zm 520 ΡΡ1+ΤΡΕ1 PE6+ TPE4 C0P1 200 //m PE6+TPE4 PP1+TPE1 Example 1-9 (9:1) 150 /zm (1:1) 10 /zm (1:1) 10 em (9:1) 150 520 (2) Evaluation of the opening property of the plastic ampoules The plastic ampules filled and sealed with physiological saline manufactured in Examples 1-7 to 1-9 were subjected to the same opening-sealing evaluation as described above. As a result, in any of the examples 1-7 to 1-9, the force required to open the plastic ampoule 1 (the split fragile portion 14) can be set to 0.40 Nm or less (relative to the discharge of the chemical liquid). The thickness of the multilayer plastic of the tubular portion 12 is a small value of 0.65 Nm/mm or less. Further, after the opening, no liquid leakage from the opening of the chemical discharge barrel 12 and the nozzle of the syringe was observed. (Manufacturing and physical property evaluation of colored plastic ampoules) 树脂 The resin materials, pigments, and ultraviolet absorbers used in the following Examples 2-1 to 2-54 and Comparative Examples 2 to 1 to 2-19 are as follows. PE1: High-pressure method low-density polyethylene, density 〇928 g/cm3, manufactured by Ube Maruzen Polyethylene Co., Ltd., trade name r Ube POLYETHYLENE (registered trademark) B128H" PE4: high-density polyethylene, density 〇.94 〇g/cm3, manufactured by Prehman Polymers Co., Ltd., trade name "ULT-ZEX (registered trademark) Uz4020B" PE5: high-density polyethylene, density 〇·965 g/cm3, Preman's polymerization 97110774 59 200940046 Manufactured by Co., Ltd., trade name "ΝΕ〇_ΖΕχ(registered trademark)Νζ65150Β" ΡΕ7. Adhesive low-density polyethylene, density 〇. 9〇3, manufactured by Puri Man Polymer Co., Ltd., "Εν—(Registered Trademark) SP0510B" PP1: Polypropylene, manufactured by Prehman Polymer Co., Ltd., trade name "B205" PP2: Polyolefin-based thermoplastic elastomer, manufactured by Mitsui Chemicals Co., Ltd., trade name "ΝΟΤΙΟ" (registered trademark) pN_3〇5〇", which is the same as τρΕ2 above. ΡΡ3: A polyolefin-based thermoplastic elastomer, manufactured by Mitsui Chemicals Co., Ltd., trade name "TAFMER (registered trademark) χΜ7〇7〇", which is the same as τρΕΐ described above. C0C1 ·•cyclic olefin copolymer (ethylene/tetracyclododecene copolymer),
Tg為70°C,三井化學股份有限公司製造,商品名「ApEL(註 φ 冊商標)APL8〇08T」 C0P1 :環狀烯烴聚合物(降葙烯系開環聚合物之氫化 物),Tg &赃’日本瑞翁股份有限公司製造,商品名 「ZE0N0R(註冊商標)750R」 顏料:黃色顏料,C. I.顏料黃95 . 紫外線吸收劑:汽巴精化股份有限公司製造,商品名 ·. 「TINUVIN(註冊商標)326」 ^商扣名 [實施例2-1〜2-8及比較例2-1〜2-4] (1)安瓿之製造 97110774 60 200940046 利用f有表4或表5所記載之層構成之熱塑性 ^填充.在封法,而製造圖8所示之形狀的 檟為2.5 mL用)。於安瓿内,填充2.5 0.8%(w/v)奥紮格雷鈉水溶液。 表4所示之熱塑性多層塑膠之各層厚度 部(藥液容納部分)之屢声。^叙 文成之本體 例2-卜2-4之實施例2]〜2'8及比較 例中,均於外層與中間層 間層與内層之間,分別献$ & 曰〈間、及中 刀別配置由上述pE7所形 20 ”之聚乙烯層,來作為黏著層。 厚度為 ❹ 97110774 200940046 [表4]Tg is 70 ° C, manufactured by Mitsui Chemicals Co., Ltd., trade name "ApEL (registered trademark) APL8 〇 08T" C0P1: cyclic olefin polymer (hydride of decene-based ring-opening polymer), Tg &赃'Manufactured by Japan Reion Co., Ltd., trade name "ZE0N0R (registered trademark) 750R" Pigment: yellow pigment, CI pigment yellow 95. UV absorber: manufactured by Ciba Specialty Chemical Co., Ltd., trade name · "TINUVIN (registered trademark) 326" ^Deduction name [Examples 2-1 to 2-8 and Comparative Examples 2-1 to 2-4] (1) Manufacture of ampoules 97110774 60 200940046 The use of f is shown in Table 4 or Table 5. The layer is made of thermoplastic ^fill. In the sealing method, the crucible of the shape shown in Fig. 8 is used for 2.5 mL). In an ampoule, 2.5 0.8% (w/v) aqueous solution of sodium ozagrel was filled. The thickness of each layer of the thermoplastic multilayer plastic shown in Table 4 (the liquid accommodating portion) is repeated. ^ The original example of the text 2 - 2-4 of the example 2] ~ 2 '8 and the comparative example, between the outer layer and the middle layer between the inner layer and the inner layer, respectively, offer $ & 曰 <, and the middle knife Do not configure the 20" polyethylene layer formed by the above pE7 as the adhesive layer. The thickness is ❹ 97110774 200940046 [Table 4]
外層(著色層) 中間層 内層 總厚度 實施例 2-1 PE1 T=1 00 β \ά Ρ=0· 63%、ΡΤ:63 U=0. 4% > UT=40 U/T=0.004 COC1 200 β m PEI 300 β m 640 β m 實施例 2-2 ΡΕ1 Τ二200 β m Ρ = 0. 06% ' ΡΤ=12 ϋ=0. 24% ' UT = 48 U/T=0.0012 COP1 200 β m PEI 200 β m 640 β m 實施例 2-3 ΡΕ1 Τ=300 β m Ρ=0.04% 、 ΡΤ=12 U=0. 12% ' UT = 36 U/T=0.0004 C0C1+PE4 (9:1) 200 β m PEI 100 β m 640 μ m 實施例 2-4 ΡΕ1 Τ=50 β m Ρ=2.5% 、 ΡΤ=125 U=0. 1% ' UT=5 U/T=0.002 COP1+PE4 (3:1) 200 β m PEI 300 β m 590 β m 實施例 2-5 ΡΕ1 Τ=300 β m Ρ=0. 04% ' ΡΤ=12 U=0. 4% ' UT=120 U/T=0.0013 C0P1+PE4 (4:1) 200 β m PEI 100 ^ m 640 β m 實施例 2-6 ΡΕ1 Τ=1 00 ^ m Ρ=0. 04% ' ΡΤ=4 U=0.38% ' UT=38 U/T=0.0038 COC1 200 β m PEI 200 β m 540 β m 實施例 2-7 PP1+PP2C8 : 2) Τ=200 β m Ρ = 0. 13% ' ΡΤ = 26 U=0. 4% ' UT=80 U/T=0.002 COP1 200 β m , PP1+PP2 (8:2) 200 β m 640 μ, m 實施例 2-8 PP1+PP3C8 : 2) Τ=1 00 /ζ m Ρ=0. 13% ' ΡΤ = 13 U:0. 4%、UT=40 U/T=0.004 C0P1+PE4 (4:1) 250 β m PP1+PP3 (8:2) 250 β m 640 β m 97110774 62 200940046 [表5] 外層C著色層) 中間屉 内層 ik ΡΕ1 *———— 比較例 2-1 Τ=40 μ m P=0. 13% ' PT=5.2 U=0_1%、UT = 4 U/T=0.0025 COC1 200 μ. m PEI 360 ^ m 640 β m PEI --- 比較例 2-2 T=100 ^ m P:0. 1%、PT = l〇 U=0. 5%、UT = 50 U/T=0.005 C0C1 200 β m PEI 300 β m 640 [jL m PEI T=100 ^ m 比較例 2-3 P=2. 6%、PT=260 U=0. 2% ' UT = 20 U/T=0.002 C0C1 200 β m PEI 300 β m 640 β m PEI — 比較例 2-4 T=100 ^ m P=0.0035% > PT=〇.35 U=0. 13% ' UT=13 U/T=0.0013 C0C1 200 β m PEI 300 β m 640 β m ❹Outer layer (colored layer) Intermediate layer inner layer total thickness Example 2-1 PE1 T=1 00 β \ά Ρ=0· 63%, ΡΤ: 63 U=0. 4% > UT=40 U/T=0.004 COC1 200 β m PEI 300 β m 640 β m Example 2-2 ΡΕ1 Τ二200 β m Ρ = 0. 06% ' ΡΤ=12 ϋ=0. 24% ' UT = 48 U/T=0.0012 COP1 200 β m PEI 200 β m 640 β m Example 2-3 ΡΕ1 Τ=300 β m Ρ=0.04% , ΡΤ=12 U=0. 12% ' UT = 36 U/T=0.0004 C0C1+PE4 (9:1) 200 β m PEI 100 β m 640 μ m Example 2-4 ΡΕ1 Τ=50 β m Ρ=2.5%, ΡΤ=125 U=0. 1% ' UT=5 U/T=0.002 COP1+PE4 (3:1 200 β m PEI 300 β m 590 β m Example 2-5 ΡΕ1 Τ=300 β m Ρ=0. 04% ' ΡΤ=12 U=0. 4% ' UT=120 U/T=0.0013 C0P1+PE4 (4:1) 200 β m PEI 100 ^ m 640 β m Example 2-6 ΡΕ1 Τ=1 00 ^ m Ρ=0. 04% ' ΡΤ=4 U=0.38% ' UT=38 U/T=0.0038 COC1 200 β m PEI 200 β m 540 β m Example 2-7 PP1+PP2C8 : 2) Τ=200 β m Ρ = 0. 13% ' ΡΤ = 26 U=0. 4% ' UT=80 U/T =0.002 COP1 200 β m , PP1+PP2 (8:2) 200 β m 640 μ, m Example 2-8 PP1+PP3C8 : 2) Τ=1 00 /ζ m Ρ=0. 13% ' ΡΤ = 13 U: 0. 4%, UT=40 U/T=0.004 C0P1+PE4 (4:1) 250 β m PP1+PP3 (8:2) 250 β m 640 β m 97110774 62 200940046 [Table 5] Outer C colored layer) Intermediate drawer inner layer ik ΡΕ1 *———— Comparative Example 2-1 Τ=40 μ m P=0. 13% ' PT=5.2 U=0_1%, UT = 4 U/T=0.0025 COC1 200 μ. m PEI 360 ^ m 640 β m PEI --- Comparative Example 2-2 T=100 ^ m P:0. 1%, PT = l〇U=0. 5%, UT = 50 U/T=0.005 C0C1 200 β m PEI 300 β m 640 [jL m PEI T=100 ^ m Comparative Example 2-3 P=2. 6%, PT=260 U=0. 2% ' UT = 20 U/T=0.002 C0C1 200 β m PEI 300 β m 640 β m PEI — Comparative Example 2-4 T=100 ^ m P=0.0035% > PT=〇.35 U=0. 13% ' UT=13 U/T=0.0013 C0C1 200 β m PEI 300 β m 640 β m ❹
G 再者,表4、表5及以下所示之表中,形成各層之樹脂 材料係使用上述略號。對於由混合樹脂所形成之層,係如 「C0C1+PE4」般以「+」連接記載所混合之樹脂材料之略 號。連接著表示混合樹脂之略號而記載之括弧内之比率, 係混合樹脂之混合比例(重量比例)。例如,記載為 「COCHPE4(9 : 1)」之情況下,表示使用以g : i之重量 比例混合C0C1與PE4之混合樹脂。 ;又,接著形成各層之樹脂材料(混合樹脂之混合比例), 而=載該層之厚度(//111)。例如,記載為「pEi _㈣ 之:況下,表示該層係由「PElj所形成之厚度為1〇… 又,表4、表5及以 下所示之表中,「P」及Γρτ」 分 97110774 63 200940046 別表示該著色層中之顏料之含有比例P(重量%)、及顏料 之含有比例P(重量%)與厚度τ( v in)之積。「U」、「ϋτ U/T」,分別表示該著色層中之紫外線吸收劑之含有比例 ' U(重量%),紫外線吸收劑之含有比例U(重量%)與厚声 、Τ(以m)之積’及紫外線吸收劑之含有比例U(重量= 厚度T(/z m)所得之商。 ' (2)觀察安瓶之外觀變化 ❹ 對表4及表5所示之實施例2-1〜2-8及比較例24〜 2-4之安瓿,確認室溫下放置丨4日後之安瓿外觀(確認 無滲出)。 將其結果示於下述表6❶再者,比較例2_2之安瓿,因 紫外線吸收劑自容器本體滲出,故於容器表面觀察到白色 微粉末。 (3)順式體含有比例之測定Further, in the tables shown in Tables 4 and 5 and below, the above-mentioned abbreviations are used for the resin materials forming the respective layers. For the layer formed of the mixed resin, the number of the resin materials to be mixed is indicated by "+" as in "C0C1 + PE4". The ratio in the brackets indicated by the outline of the mixed resin is connected, and the mixing ratio (weight ratio) of the mixed resin is used. For example, in the case of "COCHPE4 (9: 1)", it is indicated that a mixed resin of C0C1 and PE4 is mixed in a weight ratio of g: i. Further, the resin material of each layer (mixing ratio of the mixed resin) is formed, and = the thickness of the layer (//111) is carried. For example, it is described as "pEi _ (4): In the case of the layer, the thickness formed by "PElj is 1 〇... In addition, in the table shown in Table 4, Table 5 and below, "P" and Γρτ") 97110774 63 200940046 The product of the content ratio P (% by weight) of the pigment in the colored layer, and the content ratio P (% by weight) of the pigment and the thickness τ (v in) are also indicated. "U" and "ϋτ U/T" respectively indicate the content ratio of the ultraviolet absorber in the colored layer 'U (% by weight), the content ratio of the ultraviolet absorber U (% by weight) and the thick sound, Τ (in m) The product of the 'product' and the ultraviolet absorbing agent U (weight = thickness T (/zm). ' (2) Observing the appearance change of the ampoules 实施 Example 2-1 shown in Table 4 and Table 5. The ampules of ~2-8 and Comparative Examples 24 to 2-4 were confirmed, and the appearance of the ampoule after 4 days at room temperature was confirmed (no oozing was confirmed). The results are shown in Table 6 below, and the ampule of Comparative Example 2_2, Since the ultraviolet absorber oozes out from the container body, white fine powder is observed on the surface of the container. (3) Determination of the proportion of the cis isomer
對於上述實施例及比較例(紫外線吸收劑滲出之比較例 2-2除外。)之安瓿,於照度為2000 lx(D65燈)之光源下 放置25日後,藉由高效液相層析法(high performance liqind Chr〇mat0graphy,HPLC)測定内容液中之、屬於奥 紮格雷鈉之類似物質的順式體之含有比例。 、 按以下順序進行測定。首先,採集2 5虹之樣品,將 其用流動相稀釋,使總量達到4QmL,將其製成試料溶液。 自試料溶液採集5 “,藉由下述條件中之HPLC法進 行二析又,屬於奥紮格雷鈉之類似物質的順式體之量, 係藉由自動積分法測定試料溶液之各個峰面積,藉由面積 97110774 200940046 百分比法而求得。 HPLC之測定條件,如下所述。 測定波長:220 nm ,· 官柱:YMC—Pack ODS-A A-302、150x4. 6 mm i. D.、S-5 ' β m 管柱溫度:約25°c 流動相:〇. 3%乙酸銨液/甲醇混液(4 : i) 流量:1. 0 mL/分鐘 ®測定時間:20分鐘 將測定結果示於下述表6。再者,上述分析之結果,將 順式體之含有比例超過〇· 3%者判定為不良。 (4)透光率之測定 自上述實施例及比較例(紫外線吸收劑滲出之比較例 2-2除外。)之安瓶的藥液容納部,切取透光率測定用之 樣品’使用該樣品,以分光光度計測定波長為2〇〇〜38〇 nm ❹之光線透射率、及波長為6〇〇 nm之光線透射率。 又’對於在褐色玻璃安瓿(内容積為2. 5 mL用)中填充 2. 5 mL之〇. 8%(w/v)奥紮格雷鈉水溶液者,與上述同樣地 於室溫下放置14日’測定放置後之順式體之含有比例, 將其作為對照。 將測定結果不於下述表6。 97110774 65 200940046 [表6] 實施例2-1 實施例2 9 安瓿之外觀 (有無滲出) 順式體之 含有比例 200〜380 nm 未觀察到 600 nm 02% 最大0. 1% 未觀察到 49% 0. 12% 最大2. 5% 62¾The ampules of the above examples and comparative examples (except Comparative Example 2-2 in which the ultraviolet absorber was exuded) were placed under a light source of illuminance of 2000 lx (D65 lamp) for 25 days, and then subjected to high performance liquid chromatography (high). Performance liqind Chr〇mat0graphy, HPLC) Determination of the proportion of cis isomers of similar substances belonging to sodium ozagrel in the content liquid. The measurement was performed in the following order. First, a sample of 25 rainbow was collected, which was diluted with a mobile phase to make a total amount of 4QmL, which was made into a sample solution. The sample solution was collected 5", and the amount of the cis isomer of the similar substance of sodium Ozagrel was determined by the HPLC method in the following conditions. The peak area of the sample solution was determined by an automatic integration method. It is obtained by the percentage method of the area of 9710774 200940046. The HPLC measurement conditions are as follows. Measurement wavelength: 220 nm, · Column: YMC-Pack ODS-A A-302, 150x4. 6 mm i. D., S -5 ' β m Column temperature: approx. 25°c Mobile phase: 〇. 3% ammonium acetate solution/methanol mixture (4: i) Flow rate: 1. 0 mL/min® Measurement time: 20 minutes The measurement results are shown in In the following Table 6, the results of the above analysis were judged to be poor when the content of the cis is more than 3%. (4) Measurement of light transmittance from the above examples and comparative examples (ultraviolet absorber bleed out) Except for Comparative Example 2-2.) The sample solution for the ampoules of the ampoules was cut out for the sample for measuring the transmittance. Using this sample, the light transmittance at a wavelength of 2 〇〇 to 38 〇 nm was measured by a spectrophotometer. And the transmittance of light with a wavelength of 6 〇〇 nm. Also for ampoules in brown glass (within The product is 2. 5 mL with) filled with 2.5 mL of 〇. 8% (w/v) aqueous solution of sodium ozagrel, placed at room temperature for 14 days in the same manner as above. The ratio of the content is used as a control. The measurement results are not shown in the following Table 6. 97110774 65 200940046 [Table 6] Example 2-1 Example 2 9 Appearance of ampoule (with or without exudation) Content of cis isomer 200~ 380 nm No observed 600 nm 02% Maximum 0. 1% No observed 49% 0. 12% Maximum 2. 5% 623⁄4
透光率 e 根據表6所示之結果,關於實施例2-1〜2-8之安瓿, 係順式體之增加量相較於對照之褐色玻璃安瓿為同等或 其以上之結果,相對於此,比較例2_丨及2_4之安瓿,係 相較於對照之褐色玻璃安瓿為3倍以上。 另一方面,比較例2-3之安瓿’由於6〇〇⑽之光線之 透^射率低,因此難以目視觀察内容液。 [實施例2-9〜2-16] 以:實施例Η相同之方式,使用具有表7所示之層構 =熱塑性多層塑膠,藉由吹塑.填充·密封法,而製造 圖8所示之形狀的2.5 l交钿旦^ 士 * 0 r L各納量用安瓿。於安瓿内,填 兄厶5 mL之0. 8%(w/v)奥务故雨* ^兴糸格雷鈉水溶液。 97110774 66 200940046 [表7] 外層(著色層) 中間層 内層 總厚度 PE1 T=100 ^ m COC1+PE5 PEI 300 β m 640 β m 實施例2-9 P=0. 63% ' PT = 63 U=0.4% ' UT=40 (4:1) 200 μ m - U/T=0.004 PEI 實施例 2-10 T=200 β m P=0.06% 、 PT=12 U:0. 24%、UT = 48 U/T=0.0012 COP1+PE5 (4:1) 200 β m PEI 200 β m 640 β m PEI ❹ 實施例 2-11 T=300 β m P = 0. 04% ' PT = 12 U=0. 12% ' UT = 36 U/T=0.0004 COC1+PE5 (4:1) 200 β m PEI 100 β m. 640 β m PEI 實施例 2-12 T=50 β m P=2.5% > PT=125 U=0.1% > UT=5 U/T=0.002 COP1+PE5 (4:1) 200 β m PEI 300 β m 590 β m PEI 實施例 2-13 T=300 β m P:0. 04%、PT = 12 U=0.4% 、 UT=120 U/T=0.0013 COP1+PE5 (4:1) 200 μ. m PEI 100 /z m 640 μ m PEI 實施例 2-14 T= 1 00 β m P=0. 04% ' PT = 4 U = 0. 38% > UT=38 U/T=0.0038 COC1+PE5 (4:1) 200 β m PEI 200 β m 540 μ m 實施例 2-15 PP1+PP2(8 : 2) T=200 β m COP1+PE5 PP1+PP2 640 P=0_ 13% 、 PT=26 (4:1) (8:2) U=0. 4%、UT=80 U/T=0.002 200 β m 200 β m [jL Π1 PP1+PP3(8 : 2) 實施例 2-16 T=1 00 ^ m COP1+PE5 PP1+PP3 640 β m P=0. 13%、PT=13 U=0. 4¾ ' UT=40 (4:1) 250 μ. m (8:2) 250 β m U/T=0.004 實施例2-9〜2-16係將實施例2-1〜2-8中之中間層之 形成材料,變更為C0C1或C0P1與PE5之混合樹脂(重量 67 97110774 200940046 比例4 : 1)者。 —乂 ”上述(2)相同之方式,對該實施例2 9〜216觀寮 女瓶之外觀變化’結果均未觀察到紫外線吸收劑自容器本 體滲出。 [實施例2-17及2-18]Light transmittance e According to the results shown in Table 6, with respect to the ampoules of Examples 2-1 to 2-8, the increase amount of the cis isomer is equivalent to or higher than that of the control brown glass ampoule, as opposed to Thus, the ampoules of Comparative Examples 2_丨 and 2_4 were more than 3 times larger than the brown glass ampules of the control. On the other hand, in the ampoule of Comparative Example 2-3, since the light transmittance of light of 6 〇〇 (10) was low, it was difficult to visually observe the content liquid. [Examples 2-9 to 2-16] In the same manner as in the embodiment, a layered structure = thermoplastic multilayer plastic shown in Table 7 was used, and a blow molding, filling and sealing method was used to produce the film shown in Fig. 8. The shape of the 2.5 l exchange ^ ^ 士 * 0 r L each amount with the ampoule. In the ampoules, fill in the broth 5 mL of 0. 8% (w / v) Austrian rain * ^ Xinghao Gero sodium aqueous solution. 97110774 66 200940046 [Table 7] Outer layer (colored layer) The total thickness of the inner layer of the intermediate layer PE1 T = 100 ^ m COC1 + PE5 PEI 300 β m 640 β m Example 2-9 P=0. 63% ' PT = 63 U= 0.4% ' UT=40 (4:1) 200 μ m - U/T=0.004 PEI Example 2-10 T=200 β m P=0.06% , PT=12 U:0. 24%, UT = 48 U /T=0.0012 COP1+PE5 (4:1) 200 β m PEI 200 β m 640 β m PEI 实施 Example 2-11 T=300 β m P = 0. 04% ' PT = 12 U=0. 12% 'UT = 36 U/T=0.0004 COC1+PE5 (4:1) 200 β m PEI 100 β m. 640 β m PEI Example 2-12 T=50 β m P=2.5% > PT=125 U= 0.1% > UT=5 U/T=0.002 COP1+PE5 (4:1) 200 β m PEI 300 β m 590 β m PEI Example 2-13 T=300 β m P: 0. 04%, PT = 12 U=0.4%, UT=120 U/T=0.0013 COP1+PE5 (4:1) 200 μ. m PEI 100 /zm 640 μ m PEI Example 2-14 T= 1 00 β m P=0. 04 % ' PT = 4 U = 0. 38% > UT=38 U/T=0.0038 COC1+PE5 (4:1) 200 β m PEI 200 β m 540 μ m Example 2-15 PP1+PP2 (8: 2) T=200 β m COP1+PE5 PP1+PP2 640 P=0_ 13%, PT=26 (4:1) (8:2) U=0. 4%, UT=80 U/T=0. 002 200 β m 200 β m [jL Π1 PP1+PP3(8 : 2) Example 2-16 T=1 00 ^ m COP1+PE5 PP1+PP3 640 β m P=0. 13%, PT=13 U= 0. 43⁄4 ' UT=40 (4:1) 250 μ. m (8:2) 250 β m U/T=0.004 Examples 2-9 to 2-16 are in Examples 2-1 to 2-8 The material for forming the intermediate layer is changed to C0C1 or a mixed resin of COP1 and PE5 (weight: 67 97110774 200940046, ratio 4:1). - 乂" In the same manner as in the above (2), no change in the appearance of the appearance of the female bottle of the ninth to 216 spectacles was observed. As a result, no ultraviolet ray absorbing agent was observed from the container body. [Examples 2-17 and 2-18 ]
以與實施例2-1相同之方式,使用具有表8所示之層構 =之熱塑性多層塑膠’藉由吹塑·填充.密封法,而製造 =8所示之形狀的2.5 mL容納量用安瓶。於錢内,填 充2. 5 mL之〇. 8%(w/v)奥紮格雷鈉水溶液。 以與上述⑺〜⑷相同之方式,對實施例2_17 Η之安瓶’觀察其外觀變化’測定順式體含有比例, 及測定透光率。將其結果示於表9。 [表8]In the same manner as in Example 2-1, the thermoplastic multilayer plastic having the layer structure = shown in Table 8 was used to produce a 2.5 mL capacity by the blow molding, filling, and sealing method. Ampoule. In the money, fill in 2.5 mL of 〇. 8% (w / v) aqueous solution of sodium ozagrel. In the same manner as in the above (7) to (4), the ampule content ratio was measured for the ampoules of Example 2-17, and the light transmittance was measured. The results are shown in Table 9. [Table 8]
-~~^ Μ-~~^ Μ
ΡΕ1 300 μ m PEI T=100 β m 實施例2 -17ΡΕ1 300 μ m PEI T=100 β m Example 2 -17
P=0. 25%、PT=25 U=0. 4%、UT=40 U/T:0.004 — ρεΊ COP1 200 β m 640 β πι 實施例2-18 PE1 50 // mP=0. 25%, PT=25 U=0. 4%, UT=40 U/T: 0.004 — ρεΊ COP1 200 β m 640 β πι Example 2-18 PE1 50 // m
Τ=400 β m 690 β m Ρ=0·01% 、 ΡΤ=4 C0P1 U=0. 15% ' UT=6〇 200 ^ m U/T=0.000375 97110774 68 200940046 [表9] 安瓿之外觀 順式體之 透光率 ------—__ (有無渗出) 含有比例 200〜380 nm fi f) Q n m 實施例2-17 未觀察到 0. 04% 最大0.8% ~ 58¾ 實施例2-18 未觀秦到 0. 02% 最大0. 1% 65% 對照 — 0. 15% 如表9所示,對於實施例2-17〜2-18,亦判斷為具有 與實施例2-1〜2-8相同之性能。Τ=400 β m 690 β m Ρ=0·01% , ΡΤ=4 C0P1 U=0. 15% ' UT=6〇200 ^ m U/T=0.000375 97110774 68 200940046 [Table 9] Ampoule appearance cis Transmittance of the body ------___ (with or without oozing) Content ratio 200~380 nm fi f) Q nm Example 2-17 No observed 0. 04% max. 0.8% ~ 583⁄4 Example 2 18 未0。 02% max. 0% 15% 65% Control - 0. 15% As shown in Table 9, for Examples 2-17~2-18, it is judged to have the same as Example 2-1~ 2-8 the same performance.
[實施例2-1 9〜2-24及比較例2-5〜2-1〇 J ❹ ,、只 '%,便用具有表10或表11所 不之層構成之熱塑性多層塑膠,兹 而劍m f 4由吹塑·填充·密封法’ 而製造圖8所不之形狀的2. 5 内,埴亦+ n 今納置用安瓿。於安瓿 内,填充2.5 mL之〇.8%(w/v)奥 繼而,以與上述⑵〜⑷相同^雷納水溶液。 〜2-24之安瓿,觀察其外觀變化 式,對實施例2-19 及測定透光率。將其結果示 ^定順式體含有比例’[Example 2-1 9~2-24 and Comparative Example 2-5~2-1〇J ❹ , only '%, use thermoplastic multilayer plastic having a layer of Table 10 or Table 11 The sword mf 4 is made of the shape of the shape of Fig. 8 by the blow molding, filling and sealing method', and the inner shape is also used. In the ampule, 2.5 mL of 〇.8% (w/v) is filled, followed by the same as (2) to (4) above. The ampules of ~2-24 were observed for the change in appearance, and the light transmittance was measured for Examples 2-19. The result is shown as the ratio of the cis-form body.
97110774 69 200940046 [表 1 0 ]97110774 69 200940046 [Table 1 0 ]
外層(著色層) 中間層 内層 總厚度 PE1 實施例 2-19 Τ=400 β m P=0.06% ' PT=24 U=0.05% ' UT=20 U/T=0.000125 COC1 150 β m. PEI 50 " m 640 β m PEI 比較例 2-5 T = 400 β m P=0. 0375% ' PT=15 U=0. 05% ' UT = 20 U/T=0.000125 C0C1 150 β \ά PEI 50 β m 640 β m PEI 實施例 2-20 T=400 β m P=0.35% ' PT-140 U = 0. 05% > UT=20 U/T=0.000125 C0C1+PE4 (9:1) 150 μ m PEI 50 // m 640 β m PEI 比較例 2-6 T=400 β m P = 0. 45% ' PT = 180 U=0.05% ' UT=20 U/T=0.000125 C0C1+PE4 (9:1) 150 β m PEI 50 β m 640 β m PEI 實施例 2-21 T=200 β m P=0.11% 、 PT=22 U=0.1% 、 UT=20 U/T=0.0005 C0C1 200 β m PEI 200 β m 640 β m PEI 比較例 2-7 T=200 β m P = 0. 075% ' PT=15 U=0.1% > UT=20 U/T=0.0005 C0C1 200 β m PEI 200 β m 640 β m 97110774 70 200940046[表 11]Outer layer (colored layer) Intermediate layer inner layer total thickness PE1 Example 2-19 Τ=400 β m P=0.06% ' PT=24 U=0.05% ' UT=20 U/T=0.000125 COC1 150 β m. PEI 50 " m 640 β m PEI Comparative Example 2-5 T = 400 β m P=0. 0375% ' PT=15 U=0. 05% ' UT = 20 U/T=0.000125 C0C1 150 β \ά PEI 50 β m 640 β m PEI Example 2-20 T=400 β m P=0.35% ' PT-140 U = 0. 05% > UT=20 U/T=0.000125 C0C1+PE4 (9:1) 150 μ m PEI 50 // m 640 β m PEI Comparative Example 2-6 T=400 β m P = 0. 45% ' PT = 180 U=0.05% ' UT=20 U/T=0.000125 C0C1+PE4 (9:1) 150 β m PEI 50 β m 640 β m PEI Example 2-21 T=200 β m P=0.11%, PT=22 U=0.1%, UT=20 U/T=0.0005 C0C1 200 β m PEI 200 β m 640 β m PEI Comparative Example 2-7 T=200 β m P = 0. 075% ' PT=15 U=0.1% > UT=20 U/T=0.0005 C0C1 200 β m PEI 200 β m 640 β m 97110774 70 200940046 [Table 11]
外層(著色層) 中間層 内層 總厚度 實施例 2-22 PE1 Τ = 200 β m P=0.7% ' PT=140 U = 0. 1%、UT=20 U/T=0.0005 COC1+PE4 (9:1) 200 β m PEI 200 β m 640 β m 比較例 2-8 PEI T=200 β m P=l. 0% ' PT=200 U = 0. 1% ' UT=20 U/T=0.0005 COC1+PE4 (9:1) 200 β m PEI 200 β m 640 β m 實施例 2-23 PEI T=100 β m P = 0. 25%、PT = 25 U=0.2% ' UT=20 U/T=0.002 COC1 200 β m PEI 300 β m 640 β m 比較例 2-9 PEI T=100 μ m P:0. 15%、PT=15 U=0.2% ' UT=20 U/T=0.002 C0C1 200 β m PEI 300 β m 640 β m 實施例 2-24 PEI T=100 μ m P = l. 5% > PT=150 U=0.2% ' UT=20 U/T=0.002 C0C1+PE4 (9:1) 200 β m PEI 300 β m 640 β m 比較例 2-10 PEI T = 10 0 β m P=l.8% ' PT=180 U=0. 2% ' UT=20 U/T=0.002 C0C1+PE4 (9:1) 200 β m PEI 300 β m 640 β mOuter layer (colored layer) Intermediate layer inner layer total thickness Example 2-22 PE1 Τ = 200 β m P=0.7% ' PT=140 U = 0. 1%, UT=20 U/T=0.0005 COC1+PE4 (9: 1) 200 β m PEI 200 β m 640 β m Comparative Example 2-8 PEI T=200 β m P=l. 0% ' PT=200 U = 0. 1% ' UT=20 U/T=0.0005 COC1+ PE4 (9:1) 200 β m PEI 200 β m 640 β m Example 2-23 PEI T=100 β m P = 0.25%, PT = 25 U=0.2% ' UT=20 U/T=0.002 COC1 200 β m PEI 300 β m 640 β m Comparative Example 2-9 PEI T=100 μ m P: 0.15%, PT=15 U=0.2% ' UT=20 U/T=0.002 C0C1 200 β m PEI 300 β m 640 β m Example 2-24 PEI T=100 μ m P = l. 5% > PT=150 U=0.2% ' UT=20 U/T=0.002 C0C1+PE4 (9:1) 200 β m PEI 300 β m 640 β m Comparative Example 2-10 PEI T = 10 0 β m P=l.8% ' PT=180 U=0. 2% ' UT=20 U/T=0.002 C0C1+PE4 ( 9:1) 200 β m PEI 300 β m 640 β m
[表 12 ] 安瓿之外觀 (有無滲出) 順式體之 含有比例 透光率 200〜380 nm 600 nm 實施例2-19 未觀察到 0. 28% 最大4. 3% 66% 比較例2 - 5 未觀察到 0. 38% 襄大5. 3% 66% 實施例2-20 未觀察到 0.02% 最大未滿0. 1% 42% 比較例2 - 6 未觀察到 — 最大未滿0. 1 % 27% 實施例2-21 未觀察到 0. 29% 最尖4. 3% 69% 比較例2 - 7 未觀察到 0. 40% 蠢大5. 5% 66% 實施例2-22 未觀察到 0. 03% 最大0. 3% 43% 比較例2 - 8 未觀察到 — 最人未滿0. 1 % 24% 實施例2-23 未觀察到 0. 29% 最失4. 5% 68% 比較例2-9 未觀察到 0. 41% 蠢大5. 7% 66% 實施例2-24 未觀察到 0. 03% 最大未滿0. 1% 40¾ tls較彳歹丨)2 -1 0 未觀察到 — 最大未滿0. 1% 28% 對照 — 0.15% — — 97110774 71 200940046 如表12所示,於滿足上述式(1)及上述式(3)之實施例 2_19〜2_24中,具有與實施例2-1〜2-8相同之性能,相 對於此,於未滿足上述式(3)之比較例2_5〜2_1〇中產 生如下不Mf況··順式體之含有比例增加,或可見光之透 射率下降,而難以目視觀察内容液。 [實施例2-25〜2-30] 以與實施例2 -1相因夕士上、 . 址上 门之方式’使用具有表13所示之層 ❹ 構成之熱塑性多層塑膠, ^ δ ^ ,夕膠,藉由吹塑·填充.密封法,而製 Μ 狀的2·5此容納量用安瓶。於安瓶内, 真充5mL之〇.8%(w/v)M格雷鈉水溶液。 ⑩[Table 12] Appearance of Ampoule (with or without exudation) Proportion of light content of cis-type body 200~380 nm 600 nm Example 2-19 No observed 0. 28% Maximum 4. 3% 66% Comparative Example 2 - 5 No observed 0. 38% 襄 5. 6% 66% Example 2-20 No 0.02% observed Maximum not above 0. 1% 42% Comparative Example 2 - 6 Not observed - Maximum less than 0.1% 27% Example 2-21 No observed 0. 29% Sharpest 4. 3% 69% Comparative Example 2 - 7 No observed 0. 40% Stupid 5. 5% 66% Example 2-22 Not observed 0. 03% max. 0. 3% 43% Comparative Example 2 - 8 Not observed - Most people are less than 0. 1 % 24% Example 2-23 No observed 0. 29% Most lost 4. 5% 68% Comparative Example 2-9 No observed 0. 41% Stupid 5. 7% 66% Example 2-24 No observed 0. 03% Maximum less than 0. 1% 403⁄4 tls 彳歹丨) 2 -1 0 Not observed - maximum less than 0. 1% 28% control - 0.15% - 97110774 71 200940046 As shown in Table 12, in Examples 2_19 to 2_24 satisfying the above formula (1) and the above formula (3), The performances similar to those of the examples 2-1 to 2-8 are, in contrast, the comparative examples 2_5 to 2_1 in which the above formula (3) is not satisfied. Health conditions · Mf as not to increase the content ratio of the cis form, or a decrease of visible light transmittance, it is difficult to visually observe the contents liquid. [Examples 2-25 to 2-30] In the same manner as in Example 2-1, the thermoplastic multilayer plastic having the layer ❹ shown in Table 13 was used in the manner of the door-to-door, ^ δ ^ , 夕The glue is made by the blow molding, filling and sealing method, and the ampule is used in the ampule. In the ampoules, 5 mL of 〇.8% (w/v) M-Gray sodium solution was added. 10
L 表 13 JL Table 13 J
實施例2-25 Τ=400 β m P=〇. 06% > PT = 24 U=〇. 05% ^ UT=2〇 -lZIr.0. 000125 中間層 内層 總厚度 實施例2-26 實施例2-27 PET ^=400 β m P=〇. 35% ' PT = l4n U=〇. 05%、UT=2〇u^_o〇〇mMl - T=20〇 β m P=〇. 11% ' PT=22 U=0.1% 、 UT=20 U/T=0,0005 COC1+PE5 (4:1) 150 ^ mExample 2-25 Τ=400 β m P=〇. 06% > PT = 24 U=〇. 05% ^ UT=2〇-lZIr.0. 000125 Intermediate layer inner layer total thickness Example 2-26 Example 2-27 PET ^=400 β m P=〇. 35% ' PT = l4n U=〇. 05%, UT=2〇u^_o〇〇mMl - T=20〇β m P=〇. 11% ' PT=22 U=0.1%, UT=20 U/T=0,0005 COC1+PE5 (4:1) 150 ^ m
PEI (4 : U 50 640 βΰί COC1+PE5 (4:1) 150 /z m COC1+PE5 50PEh 640PEI (4 : U 50 640 βΰί COC1+PE5 (4:1) 150 /z m COC1+PE5 50PEh 640
PEI 實施例2-28 PEI T=20〇 μ m P=〇·7% 、 PT=14〇 U=0.1% 、 UT=20 U/T=Q.0005 TEl~ 2〇Vl\ 2〇r"m 640 “ COC1+PE5 (4:1) 200 β m 20〇E!am 640 ^ m 實施例2-29 實施例2-30 T = 1 00 /z m P:〇.25%、PT=25 U=0. 2%、UT = 20 u/t=o.nn^ ΤΕΪ T=100 P = l. 5%、PT=15〇 U = 0. 2%、UT = 20 U/T=Q.002_ COC1+PE5 (4:1) 200 β m PEI β yin ,, 300 /zm 640 βΏι COC1+PE5 (4:1) 200 β m PEI c ,n 300 640 βίΆ 97110774 72 200940046 實施例2-25〜2~30係將實施例2-19〜2-24中之中間層 之形成材料’變更為C0C1與PE5之混合樹脂(重量比例4: 1)者。 以與上述(2)相同之方式,對該實施例2-25〜2-30觀察 八外觀變化’結果均未觀察到紫外線吸收劑自容器本體滲 出。 [實施例2-31〜2-33及比較例2-Π〜2-13] ❹=與實施例2]相同之方式,使用具有纟14所示之層 =熱塑性多層塑膠,藉由吹塑·填充·密封法,而製 &圖8所示之形狀的2 5 “ 9 , τ 分π置用女瓿。於安瓿内, 、充2.5 mL之〇.8%(w/v)奥紮格雷 繼而,以與上述(2)〜(4)相同之十辰 〜2-3彳 > 〜π & # u 之方式,對實施例2-31 Ζ 33之文瓿觀察其外觀變化 及制佘令上安 ^ 挪定順式體含有比例’ 及測疋透先率。將其結果示於表丨5。 97110774 73 200940046 [表 14] ^Γ¥~(著色層) 中間層 内層 總厚度 實施例2-31 m、广 /%%0 厶3 5 0 0 7 oooo 0··= -400T E 11 = =/ ΟΛ Αμα 2 • ο 11 0〇 II II 5 ΤΤ7 PU8 C0C1+PE4 (9:1) 150 β v\ £o P5 m m ^u· ο 4 比較例2-11 4 • ο ο 3 II=5 ΤΤ7 PU8 m、、ο /%%ο ΛΜ.1 5 ο 0 7. ο ο ο ο ο_·= 400Τ Ε II 11= / ρ τ ρ υ υ COC1+PE4 (9:1) 150 amPEI Example 2-28 PEI T=20〇μ m P=〇·7%, PT=14〇U=0.1%, UT=20 U/T=Q.0005 TEl~ 2〇Vl\ 2〇r"m 640 "COC1+PE5 (4:1) 200 β m 20〇E!am 640 ^ m Example 2-29 Example 2-30 T = 1 00 /zm P: 〇.25%, PT=25 U=0 2%, UT = 20 u/t=o.nn^ ΤΕΪ T=100 P = l. 5%, PT=15〇U = 0. 2%, UT = 20 U/T=Q.002_ COC1+PE5 (4:1) 200 β m PEI β yin ,, 300 /zm 640 βΏι COC1+PE5 (4:1) 200 β m PEI c , n 300 640 βίΆ 97110774 72 200940046 Example 2-25~2~30 The material for forming the intermediate layer in Examples 2-19 to 2-24 was changed to a mixed resin of COC1 and PE5 (weight ratio 4:1). In the same manner as in the above (2), the example 2 25~2-30 observed eight appearance changes' results were not observed to seep out of the ultraviolet absorber from the container body. [Examples 2-31 to 2-33 and Comparative Example 2-Π~2-13] ❹ = and Example 2 In the same way, using the layer = thermoplastic multilayer plastic shown in 纟14, by the blow molding, filling and sealing method, the shape of the shape shown in Fig. 8 is 2 5 "9, τ π π female Hey. Within the Anzhen, fill 2.5 mL of 〇.8% (w/v) Ozagray, and then the same as the above (2) ~ (4) ten minutes ~ 2-3 彳 > ~ π &# u In the manner of Example 2-31 Ζ 33, the change in appearance and the ratio of the cis-form of the 佘 ^ 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 The results are shown in Table 5. 97110774 73 200940046 [Table 14] ^Γ¥~(Colored layer) Total thickness of inner layer of intermediate layer Example 2-31 m, width/%%0 厶3 5 0 0 7 oooo 0··= -400T E 11 ==/ ΟΛ Αμα 2 • ο 11 0〇II II 5 ΤΤ7 PU8 C0C1+PE4 (9:1) 150 β v\ £o P5 mm ^u· ο 4 Comparative Example 2-11 4 • ο ο 3 II=5 ΤΤ7 PU8 m , ο /%%ο ΛΜ.1 5 ο 0 7. ο ο ο ο ο_·= 400Τ Ε II 11= / ρ τ ρ υ υ COC1+PE4 (9:1) 150 am
Eo p 5 m ^ 4 6 m ^ 實施例2-32 ❹ 比較例2-12 實施例2-33 PE1 Τ=200 β m P = 0. 005%、PT=1, U = 0. 15% ' UT = 30 U/T=Q.00075 ΤΙΊ ' T=200 β m P = 〇. 002%、PT=0. U = 0. 15% ' UT = 30 U/T=Q.00075 PET T=100 ^ m P=〇.015% 、 PT=1_ U = 0. 3%、UT = 30 U/T=0.003 C0C1+PE4 (9:1) 200 β m 4 6 m =1 1 o Eo P2 m C0C1+PE4 (9:1) 200 β m 4 6 m 1 o Eo P2 m C0C1+PE4 (9:1) 200 β m 瓜 0 4 6 m 1 o Eo P3 PEI T=100 β m P=〇.005¾ > PT=0, U=0. 3% ' UT=30 U/T=0.003 C0C1+PE4 (9:1) 200 β m PEI 300 β m 640 β m [表 15] 透光率 安瓿之外觀 順式體之 實施例 2-31 K ^ nr UA 来觀察至1 J ^ ^ PO V*} 0. 27% zuu~ oou nm 最大4. 8% buu nm 60% 比較例 2-11 来觀察萝 0. 45% 最大6. 8% 63% 實施垧 2-32 未觀察萝 0. 29% 最大4. 8% 60% 較例_ 2-12 来觀察至1 0. 5% 嘉;大6. 8% 61% 實施例. 2-33 来觀察尹 0. 28% 最大4. 8% 58¾ ίϊι較例 2-13 夫觀察至1 0. 51% 最大7. 0% 60% 對聪 15% 如表15所示’於滿足上述式(1)及上述式(2)之實施例 2 — 31〜2-33中’具有與實施例2-1〜2-8相同之性能,相 對於此,於未滿足上述式(1)之比較例2-11〜2-13中,產 生如下不良情況:順式體之含有比例增加,或可見光之透 97110774 74 200940046 射率下降’而難以目視觀察内容液。 [實施例2-34〜2-36 ] 以與實施例2-1相同之古4、 德》 ^ 之方式’使用具有表16所示之層 構成之熱塑性多層塑膠 μ 胗藉由吹塑.填充.密封法,而製 _ ^ 8所示之形狀的2.5mL容納量用安瓶。於安瓶内, 真充2‘5 mku%(w/v)奥紫格雷納水溶液。 L 表 16 ] ---- _L間層 — 内層 總厚度 2 —_丨 COC1+PE5 (4:1) 150 β m PEI 50 /z m 640 β m 0 ----- C0C1+PE5 (4:1) 200 β m PEI 200 β m 640 β in 5 C0C1+PE5 (4:1) 200 β m PEI 300 μ. m 640 β m 一丨小π見抛例w〜2-33中之中問居 實施例 2-34 Ρτ U=0. 075% ' UT=3h ——-^p^ooilis30 實施例 2-35 ?:計SosV1、Ρτ U=0. 15% n UT=3fl — -^ia〇〇iI30 實施例 2-36 LSMisV1、pT U=〇.3% ^ UT=3〇 ———_UZ1^L_003 之 1)者 3成材料,變更為C〇C1與啦之混合樹脂(重量比例4: 者。 觀 體 翁以與上述⑵相同之方式,對該實施例2-34〜2一36, =外觀變化’結果均未觀察到紫外線吸收劑自容器本 [貝施例2-37〜2-42及比較例2_14〜2_19] 一以與實施例2-1相同之方式’使用具有表”或表 2層構成之熱塑性多層塑膠,藉由吹塑.填充 而製造圖8所示之形狀的"mL容納量用安c瓶 97110774 75 200940046 内,填充2. 5 mL之0. 8%(w/v)奥紮格雷納水溶液。 繼而,以與上述(2)〜(4)相同之方式,對實施例2-37 〜2-42之安瓿,觀察其外觀變化,測定順式體含有比例, 及測定透光率。將其結果示於表19。 [表 17 ] 外層(著色層) 中間層 内層 總厚度 實施例 2-37 PE1 Τ=400 β m Ρ = 0· 1%、PT = 40 U=0.013% > UT=5. 2 U/T=0.0000325 COC1+PE4 (9:1) 150 β \ά PEI 50 // m 640 β m 比較例 2-14 ΡΕ1 Τ=400 β m Ρ=0.1% > ΡΤ=40 U = 0. 005% ' UT = 2 U/T=0.0000125 COC1+PE4 (9:1) 150 β \ά PEI 50 β m 640 β m 實施例 2-38 ΡΕ1 Τ=400 β m Ρ:0· 1%、ΡΤ = 40 U=0. 4% > UT = 160 υ/τ:ο·001 COC1+PE4 (9:1) 150 ^ m PEI 50 ^ m 640 β m 比較例 2-15 ΡΕ1 Τ=400 β m Ρ=0.1% > ΡΤ=40 U=0.5% > UT=200 U/T=0.00125 COC1+PE4 (9:1) 150 ^ m PEI 50 β m 640 β m 實施例 2-39 ΡΕ1 Τ=250 β m Ρ = 0. 16% ' ΡΤ=40 U=0.02% ' UT=5 U/T=0.00008 C0C1+PE4 (9:1) 200 β m PEI 150 μ wi 640 β m 比較例 2-16 ΡΕ1 Τ=250 β m Ρ = 0. 16% ' ΡΤ = 40 U = 0. 01%、UT = 2.5 U/T:0.00004 C0C1+PE4 (9:1) 200 β m PEI 150 β m 640 β m 97110774 76 200940046 [表 18 ] (著色層1 中間層 内層 總厚度 實施例 2-40 PE1 Τ=250 β m Ρ = 〇· 16%、PT=40 U=0.6% 、 UT=15〇 ΙΙ/Τ = 0. 0024 C0C1+PE4 (9:1) 200 β m PEI 150 μ m 640 β m 比較例 2-17 ~ρεΤ ~~ Τ=250 β m Ρ = 〇. 16% ' ΡΤ=40 U=0.8% 、 UT=2〇〇 ϋ/Τ=0.0032 COC1+PE4 (9:1) 200 β m PEI 150 β m 640 β m 實施例 2-41 τη Τ=200 β m Ρ=0. 2% ' ΡΤ=40 U=0. 03% > UT = 6 If/T=0. 00015 C0C1+PE4 (9:1) 200 β m PEI 200 β in 640 β m 比較例 2-18 ~Ffl - Τ=200 β m Ρ=0. 2% ' ΡΤ=40 ϋ=0. 01% ' UT=2 ϋ/Τ=0.00005 COC1+PE4 (9:1) 200 β m PEI 200 β m 640 β m 實施例 2-42 ΤΕΐ - Τ=200 β m Ρ=〇. 2% ' ΡΤ=40 U=0.7% ' UT=14〇 ϋ/Τ=0.0035 COC1+PE4 (9:1) 200 β m PEI 200 β m 640 β m 比較例 2-19 ΡΕ1 Τ=200 β m Ρ=〇· 2%、ΡΤ=40 U=l% ' UT=200 U/T=0.005 C0C1+PE4 (9:1) 20 0 β m PEI 200 β m 640 β m [表 19] 安瓿之外-(有無滲出 觀、 順式體之 ) 含有比例 透光率 200〜380 run 600 nm 貫施例 2-37 束觀祭至1. 0. 25% 最大4. 7% 58% 比較例 2-14 未觀察至^ 0. 32% 最大5. 5% 56¾ 實施例 2-38 未觀祭至 0. 02% 最大未滿0. 1% 57% 4較私j 2 -15 来觀秦至L __0. 02% 最大未滿0. 1 % 57% 實施例 2-39 未 11¾ 察 3£_j 0. 27% 最大4. 8¾ 56% λ較例 2-16 来觀察 0. 33% 最大5 4¾ 53% 實施例 2-40 来觀察至1 0. 02% ~~最大未滿0 1 % 56¾ 昆較你j 2-17 夫觀察至1 0. 02% 最大来湛0 1% 53% 實施例 2-41 耒觀察f丨 U. 26% 最大4 8¾ 53% 比較例 2-18 来觀察势 ... 0. 5¾ 蛊大7 9¾ 54¾ 實施例 2-42 未觀察至1 07021 最大夫潘0 1% ^9¾ 比較例 2-19 觀察到 -—--0.15¾ 如表19所示’於滿足上述式(丨)及上述式(2)之實施例 2-37〜2-42中,具有與實施例24〜2_8相同之性能,相 97110774 77 200940046 對於此,於未滿足上述式(2)之比較例2_i4〜2_i9中產 生如下不良情況:順式體之含有比例增加,或可見光之透 射率下降,而難以目視觀察内容液。 [實施例2-43〜2-48] 以與實施例2-1相同之方式,使用具有表2〇所示之層 構成之熱塑性多層塑膠,藉由吹塑.填充·密封法,而製 造圖8所不之形狀的2 5 mL容納量用安瓿。於安瓿内, 填充2.5 mL之〇.8%(w/v)奥紮格雷鈉水溶液。 [表 20]Eo p 5 m ^ 4 6 m ^ Example 2-32 ❹ Comparative Example 2-12 Example 2-33 PE1 Τ=200 β m P = 0. 005%, PT=1, U = 0. 15% ' UT = 30 U/T=Q.00075 ΤΙΊ ' T=200 β m P = 〇. 002%, PT=0. U = 0. 15% ' UT = 30 U/T=Q.00075 PET T=100 ^ m P=〇.015%, PT=1_ U = 0. 3%, UT = 30 U/T=0.003 C0C1+PE4 (9:1) 200 β m 4 6 m =1 1 o Eo P2 m C0C1+PE4 ( 9:1) 200 β m 4 6 m 1 o Eo P2 m C0C1+PE4 (9:1) 200 β m Melon 0 4 6 m 1 o Eo P3 PEI T=100 β m P=〇.0053⁄4 > PT= 0, U=0. 3% ' UT=30 U/T=0.003 C0C1+PE4 (9:1) 200 β m PEI 300 β m 640 β m [Table 15] Light transmittance Ampoule appearance cis-form implementation Example 2-31 K ^ nr UA to observe 1 J ^ ^ PO V*} 0. 27% zuu~ oou nm Maximum 4. 8% buu nm 60% Comparative Example 2-11 to observe the radish 0. 45% Maximum 6 8% 63% Implementation 垧2-32 Unobserved radish 0. 29% Maximum 4. 8% 60% Comparative _ 2-12 to observe 1 0. 5% Jia; Large 6. 8% 61% Example. 2-33 To observe Yin 0. 28% Maximum 4. 8% 583⁄4 ίϊι Comparative Example 2-13 Observed to 1 0. 51% Maximum 7. 0% 60% For Cong 15% As shown in Table 15 Formula (1) and the above formula (2) Example 2 - 31 to 2-33 'has the same performance as the examples 2-1 to 2-8, whereas in the comparative examples 2-11 to 2-13 which do not satisfy the above formula (1), The following unfavorable situation: the proportion of cis-forms increases, or the transmittance of visible light is 97110774 74 200940046, and the rate of radiation drops, and it is difficult to visually observe the content liquid. [Examples 2-34 to 2-36] In the same manner as in Example 2-1, the thermoplastic multilayer plastic material having the layer composition shown in Table 16 was used to be filled by blow molding. . Sealing method, and the 2.5 mL capacity of the shape shown in _ ^ 8 is used in ampoules. In the An's bottle, it is really filled with 2'5 mku% (w/v) aqueous solution of Ou Vilagren. L Table 16 ] ---- _L interlayer - inner layer total thickness 2 —_丨COC1+PE5 (4:1) 150 β m PEI 50 /zm 640 β m 0 ----- C0C1+PE5 (4:1 ) 200 β m PEI 200 β m 640 β in 5 C0C1+PE5 (4:1) 200 β m PEI 300 μ. m 640 β m a small π see a throwing example w~2-33 2-34 Ρτ U=0. 075% ' UT=3h ——-^p^ooilis30 Example 2-35 ?: Count SosV1, Ρτ U=0. 15% n UT=3fl — -^ia〇〇iI30 Implementation Example 2-36 LSMisV1, pT U=〇.3% ^ UT=3〇———1_ZZ1^L_003 1) The material is changed to C混合C1 and mixed resin (weight ratio 4: In the same manner as in the above (2), the results of the examples 2-34~2 to 36, = appearance change were not observed in the UV absorber from the container [Bei Shi Example 2-37~2-42 and comparison Example 2_14 to 2_19] In the same manner as in Example 2-1, a thermoplastic multilayer plastic having a watch or a two-layer structure was used, and the shape of the shape shown in Fig. 8 was produced by blow molding. The amount of the Anc bottle 97110774 75 200940046, filled with 2. 5 mL of 0. 8% (w / v) Ozagrena aqueous solution. Then, with In the same manner as described in (2) to (4), the ampules of Examples 2-37 to 2-42 were observed for changes in appearance, the ratio of cis isomers was measured, and the light transmittance was measured. The results are shown in Table 19. [Table 17] Outer layer (colored layer) Intermediate layer inner layer total thickness Example 2-37 PE1 Τ=400 β m Ρ = 0·1%, PT = 40 U=0.013% > UT=5. 2 U/T =0.0000325 COC1+PE4 (9:1) 150 β \ά PEI 50 // m 640 β m Comparative Example 2-14 ΡΕ1 Τ=400 β m Ρ=0.1% > ΡΤ=40 U = 0. 005% ' UT = 2 U/T=0.0000125 COC1+PE4 (9:1) 150 β \ά PEI 50 β m 640 β m Example 2-38 ΡΕ1 Τ=400 β m Ρ: 0· 1%, ΡΤ = 40 U=0 4% > UT = 160 υ/τ: ο·001 COC1+PE4 (9:1) 150 ^ m PEI 50 ^ m 640 β m Comparative Example 2-15 ΡΕ1 Τ=400 β m Ρ=0.1% > ΡΤ=40 U=0.5% > UT=200 U/T=0.00125 COC1+PE4 (9:1) 150 ^ m PEI 50 β m 640 β m Example 2-39 ΡΕ1 Τ=250 β m Ρ = 0. 16% ' ΡΤ=40 U=0.02% ' UT=5 U/T=0.00008 C0C1+PE4 (9:1) 200 β m PEI 150 μ wi 640 β m Comparative Example 2-16 ΡΕ1 Τ=250 β m Ρ = 0. 16% ' ΡΤ = 40 U = 0. 01%, UT = 2.5 U/T: 0.00004 C 0C1+PE4 (9:1) 200 β m PEI 150 β m 640 β m 97110774 76 200940046 [Table 18] (Colored layer 1 Intermediate layer inner layer total thickness Example 2-40 PE1 Τ=250 β m Ρ = 〇· 16 %, PT=40 U=0.6%, UT=15〇ΙΙ/Τ = 0. 0024 C0C1+PE4 (9:1) 200 β m PEI 150 μ m 640 β m Comparative Example 2-17 ~ρεΤ ~~ Τ= 250 β m Ρ = 〇. 16% ' ΡΤ=40 U=0.8%, UT=2〇〇ϋ/Τ=0.0032 COC1+PE4 (9:1) 200 β m PEI 150 β m 640 β m Example 2 41 τη Τ=200 β m Ρ=0. 2% ' ΡΤ=40 U=0. 03% > UT = 6 If/T=0. 00015 C0C1+PE4 (9:1) 200 β m PEI 200 β in 640 β m Comparative Example 2-18 ~Ffl - Τ=200 β m Ρ=0. 2% ' ΡΤ=40 ϋ=0. 01% ' UT=2 ϋ/Τ=0.00005 COC1+PE4 (9:1) 200 β m PEI 200 β m 640 β m Example 2-42 ΤΕΐ - Τ=200 β m Ρ=〇. 2% ' ΡΤ=40 U=0.7% ' UT=14〇ϋ/Τ=0.0035 COC1+PE4 (9 :1) 200 β m PEI 200 β m 640 β m Comparative Example 2-19 ΡΕ1 Τ=200 β m Ρ=〇· 2%, ΡΤ=40 U=l% ' UT=200 U/T=0.005 C0C1+PE4 (9:1) 20 0 β m PEI 200 β m 640 β m [Table 19] Outside the ampoule - (with or without exudation, cis-form) Content ratio Light rate 200~380 run 600 nm Example 2-37 bundle view to 1. 0. 25% max 4. 7% 58% Comparative example 2-14 Not observed to ^ 0. 32% max 5. 5% 563⁄4 Example 22-3 No observation to 0. 02% Maximum less than 0. 1% 57% 4 Private j 2 -15 to Guan Qin to L __0. 02% Maximum less than 0. 1 % 57% Example 2 -39 未113⁄4 察3£_j 0. 27% max 4. 83⁄4 56% λ compared to Example 2-16 to observe 0. 33% max 5 43⁄4 53% Example 2-40 to observe 1 0. 02% ~~ Maximum less than 0 1 % 563⁄4 Kun compared to your j 2-17 husband observed to 1 0. 02% maximum to Zhan 0 1% 53% Example 2-41 耒 observation f丨U. 26% maximum 4 83⁄4 53% Comparative example 2-18 to observe the potential... 0. 53⁄4 蛊大 7 93⁄4 543⁄4 Example 2-42 Not observed to 1 07021 Max Fupan 0 1% ^93⁄4 Comparative Example 2-19 Observed ----0.153⁄4 19 shows that in the embodiments 2-37 to 2-42 satisfying the above formula (丨) and the above formula (2), the performance is the same as that of the examples 24 to 2_8, and the phase is 97110774 77 200940046. In Comparative Example 2_i4 to 2_i9 of the above formula (2), the following problem occurs: the content of the cis is increased, or the transmission of visible light The rate is lowered, and it is difficult to visually observe the content liquid. [Examples 2-43 to 2-48] In the same manner as in Example 2-1, a thermoplastic multilayer plastic having a layer structure shown in Table 2A was used, and a pattern was produced by a blow molding, filling and sealing method. The volume of 2 5 mL of 8 shapes is ampoules. In an ampoule, fill 2.5 mL of 〇.8% (w/v) aqueous solution of sodium Ozagrel. [Table 20]
實施例2-43 Τ=400 β m P = 0. 1% > PT = 40 U = 0. 013% ' UT=5 2 U/T=0.〇〇〇〇3?r COC1+PE5 (4:1) 150 ^ m PEI 50 // m 640 β m 實施例2-44 PEI T=400 μ. m P=0. 1% ' PT = 40 U=0. 4%、UT=160 U/T=〇.001 COC1+PE5 (4:1) 150 β vn PEI 50 ^ m 640 β m 實施例2 - 4 5 FE1 T=250 μ. m P=0. 16%、PT=40 U=0. 02% ' UT=5 U/T=0.00008 COC1+PE5 (4:1) 200 β m PEI 150 μ m 640 β m PEI ~~- 實施例2 - 4 6 T=250 β m P=0. 16%、PT = 40 U=0. 6% ' UT = 150 U/T=0.0024 COC1+PE5 (4:1) 200 μ. m PEI 150 ^ m 640 β m PK1 實施例2 - 4 7 T=200 β m P=0. 2% > PT=40 U=0· 03%、UT:6 U/T=0.00015 COC1+PE5 (4:1) 200 β m PEI 200 β m 640 β m 實施例2 - 4 8 _________ PEI T=200 β m P=0. 2%、PT = 40 U = 0. 7% > UT = 140 U/T=0.0035 COC1+PE5 (4:1) 200 β m PEI 200 β m 640 β m ❹ 之形成材料,變更為C0C1與PE5之混合樹脂(重量比例4: 97110774 78 200940046 ❹ 1)者。 以與上述(2)相同夕士 1 〇 ^ 察其外觀變化,牡果的:式,對該實施例2-43〜2—48,觀 渗出。 、σ果均未觀察到紫外線吸收劑自容器本體 [實細例2-49〜2~5i J 以與實施例2-1相同之 構成之熱塑性多層塑膠,H’f用具有表以所示之層 造圖8所示之形狀二=容 填充2. 5 mL之〇 /、 、I用女瓿。於安瓿内, 奥紫格雷鋼 円 繼而,以與上述(2)〜( 展 〜2一51之安瓶,觀察其外觀變’對實施例2-49 及測定逯光率。將其結果示於表22。疋順式體含有比例’ [表 211Example 2-43 Τ=400 β m P = 0. 1% > PT = 40 U = 0. 013% ' UT=5 2 U/T=0.〇〇〇〇3?r COC1+PE5 (4 :1) 150 ^ m PEI 50 // m 640 β m Example 2-44 PEI T=400 μ. m P=0. 1% ' PT = 40 U=0. 4%, UT=160 U/T= 〇.001 COC1+PE5 (4:1) 150 β vn PEI 50 ^ m 640 β m Example 2 - 4 5 FE1 T=250 μ. m P=0. 16%, PT=40 U=0. 02% ' UT=5 U/T=0.00008 COC1+PE5 (4:1) 200 β m PEI 150 μ m 640 β m PEI ~~- Example 2 - 4 6 T=250 β m P=0. 16%, PT = 40 U=0. 6% ' UT = 150 U/T=0.0024 COC1+PE5 (4:1) 200 μ. m PEI 150 ^ m 640 β m PK1 Example 2 - 4 7 T=200 β m P= 0. 2% > PT=40 U=0· 03%, UT:6 U/T=0.00015 COC1+PE5 (4:1) 200 β m PEI 200 β m 640 β m Example 2 - 4 8 _________ PEI T=200 β m P=0. 2%, PT = 40 U = 0. 7% > UT = 140 U/T=0.0035 COC1+PE5 (4:1) 200 β m PEI 200 β m 640 β m ❹ The material to be formed was changed to a mixed resin of C0C1 and PE5 (weight ratio 4: 97110774 78 200940046 ❹ 1). The appearance change was observed in the same manner as in the above (2), and the appearance of the fruit was as follows: for the example 2-43 to 2-48, the exudation was observed. The σ fruit was not observed from the container body [the actual example 2-49~2~5i J was the same as the thermoplastic multilayer plastic of the composition of Example 2-1, and the H'f has a table as shown. The layer 2 is shown in Figure 8. The volume is filled with 2. 5 mL of 〇/, and I is used by niece. In the Anzheng, the Azigalel steel shovel was followed by the above (2) ~ (Exhibition ~ 2 - 51 ampoules, observing its appearance changed) to Example 2-49 and measuring the luminosity. The results are shown in Table 22. 疋 cis type contains the ratio ' [Table 211
實施例2-49 9Kc〇Pl PP1 ❹ 實施例2~5〇 實施例2 ~ 51 ΡΕ1 Τ=50 β m P=3 ' PT=150 U=0. 2% ' UT=l〇 U/T=0.004 TEl T = 1 00 仁 m P = l. 5% > PT=150 U = 0. 4%、UT=40 U/T=0.004 ΤΕΓ T=200 β m P=0. 75%、PT=150 U = 0. 7% ' UT=140 II/T = Q. 0035 300 640 200 “ni 3〇SE1“m 640 n 2〇C〇〇P- 20^m B40,m 97110774 79 200940046 [表 22]Example 2-49 9Kc〇Pl PP1 实施 Example 2~5〇 Example 2 ~ 51 ΡΕ1 Τ=50 β m P=3 ' PT=150 U=0. 2% ' UT=l〇U/T=0.004 TEl T = 1 00 仁 m P = l. 5% > PT=150 U = 0. 4%, UT=40 U/T=0.004 ΤΕΓ T=200 β m P=0. 75%, PT=150 U = 0. 7% ' UT=140 II/T = Q. 0035 300 640 200 “ni 3〇SE1“m 640 n 2〇C〇〇P- 20^m B40,m 97110774 79 200940046 [Table 22]
---~_______ υ > 1 U7& - --------- 如表 22 所示’ 2-49〜2-51中,具有與實施例2-1〜2一8相同之性能。 [實施例2-52〜2-54] ❹ 以與實施例2-1相同之方式,使用具有表㈡所示之層 構成之熱塑性多層塑膠,藉由吹塑.填充·密封法 造圖8所示之形狀的2 5此容納量用安瓶。於安瓶内, 填充2.5 mL之〇.8%(w/v)奥紮格雷鈉水溶液。 [表 23] ❹ 實施例 2-52 Jim UT = l〇 -^^004. 實施例 2-53ll&r- 實施例2-54 -^^1^0035 I3間層 C0P1+PE5 (4:1) 250 β m C0P1+PE5 (4:1) 200 β m COP1+PE5 (4:1) 200 β m PEI 300 β ηι 640 μ. m PEI 300 /z m 640 以 m PEI 200 ^ m 640 /z m 實施例2-52〜2-54係將^施例2_49〜2_51^^中間^ =成材料’變更為c0pl與PE5之混合樹脂(重量比例4: 丄)者。察同二方式’對該實施例2_52〜2-54,觀 渗出。 、、σ果均未觀察到紫外線吸收劑自容器本體 97110774 200940046 再者上述發明雖被提供作為本發明之例*實施形態, 但其只不過為例示,並非作限定性轉^上述發明所屬之 技術領域之業者所清楚的本發明之變形例,包含於下 請專利範圍内。 (產業上之可利用性) 本發明之塑膠安親 封藥液之塑膠安瓿, 法而形成之塑膠安瓿 ,例如適合作為用以無菌性容納及密 特別適合作為藉由吹塑·填充·密封 維二^之著色塑膠容器,適合作為用以對容器内部 夕μΛΓ ’且有效率地遮蔽紫外11域之光線自容器 因紫^至内#的塑膠容器’特別適合作為用以容納易於 、:而產生分解、劣化之藥劑的塑膠容器。 、 【圖式簡單說明】 本發明之塑膠安瓶之一實施形態的前視圖。 係圖1所示之塑膠安瓶之左侧視圖。 圖3係圖1所示之塑膠安瓿之俯視圖。 圖4係圖1所示之塑膠錢之仰視圖。 圖5係圖1所示之塑膠安瓶之左側剖面圖。 圖6係圖1所示之塑膠安瓿之Α-Α剖面。 圖7係严1所示之塑膠安瓶之Β-Β剖面。 :之IT:剖^ 97110774 200940046 圖10係表示形成著色塑膠容器之熱塑性多層塑膠之層 構成之進而其他例的剖面圖。 圖11係表示著色塑膠容器之一實施形態的前視圖。 圖12係圖11所示之著色塑膠容器之侧視圖。 圖13係圖11所示之著色塑膠容器之俯視圖。 圖14係圖π所示之著色塑膠容器之仰視圖。 圖15係圖11所示之著色塑膠容器之侧剖面圖。 【主要元件符號說明】 ❹ 10 塑膠安瓿 11 ' 111 藥液容納部 11 a、111 a 開口端 12 、 112 藥液排出筒部 13 、 113 頂部 14 、 114 脆弱部 15 、 115 中心軸 16 、 116 底部 17 ' 117 肩部 18 、 104 中間層 19 内層 20 外層 21 ' 22 黏著層 23 、 123 藥液容納部之 24 、 25 、 124 、 125 凸緣 26 、 126 藥液排出筒部 97110774 82 200940046 27 ' 127 頂部之外表面 28 、 128 掰片 29 、 32 、 129 、 132 平板部 -. 30、33、130、133 倒角部 、31 ' 131 增強片 101 著色層 102 環狀烯烴聚合物層 103 、 105 、 106 聚烯烴層 ® 110 著色塑膠安瓿 97110774 83---~_______ υ > 1 U7& - --------- As shown in Table 22, '2-49 to 2-51, have the same performance as Examples 2-1 to 2-8 . [Example 2-52 to 2-54] 热塑性 In the same manner as in Example 2-1, a thermoplastic multilayer plastic having a layer structure shown in Table (2) was used, and a pattern was produced by a blow molding, filling and sealing method. The shape of the display is 2 5 and the capacity is in ampoules. In an ampoule, fill 2.5 mL of 〇.8% (w/v) aqueous solution of sodium ozagrel. [Table 23] 实施 Example 2-52 Jim UT = l〇-^^004. Example 2-53ll&r- Example 2-54 -^^1^0035 I3 interlayer C0P1+PE5 (4:1) 250 β m C0P1+PE5 (4:1) 200 β m COP1+PE5 (4:1) 200 β m PEI 300 β ηι 640 μ. m PEI 300 /zm 640 in m PEI 200 ^ m 640 /zm Example 2 -52~2-54 is the case where the compound 2_49~2_51^^ intermediate ^=material is changed to the mixed resin of c0pl and PE5 (weight ratio 4: 丄). The second method was observed, and the examples 2_52 to 2-54 were observed to seep out. The ultraviolet absorbing agent is not observed from the container body 97110774 200940046. Further, although the above invention is provided as an example of the present invention, it is merely an exemplification, and is not intended to be a limitation. Variations of the invention as apparent to those skilled in the art are included in the scope of the following patent. (Industrial Applicability) The plastic ampule formed by the plastic ampule of the present invention is suitable for use as a sterilized accommodating and densely suitable as a blow molding, filling and sealing dimension. The color-colored plastic container of the second color is suitable as a plastic container for the purpose of accommodating the interior of the container and efficiently shielding the ultraviolet 11 field from the container due to the purple to internal #. A plastic container for decomposing and deteriorating chemicals. BRIEF DESCRIPTION OF THE DRAWINGS [Embodiment of the drawings] A front view of an embodiment of a plastic ampoule of the present invention. Figure 1 is a left side view of the plastic ampoules shown in Figure 1. Figure 3 is a top plan view of the plastic ampule shown in Figure 1. Figure 4 is a bottom view of the plastic money shown in Figure 1. Figure 5 is a left side cross-sectional view of the plastic ampoules shown in Figure 1. Figure 6 is a cross-section of the plastic ampule shown in Figure 1. Figure 7 is a Β-Β profile of the plastic ampoules shown in Yan. IT: Section: 97110774 200940046 Fig. 10 is a cross-sectional view showing another example of a layer of a thermoplastic multilayer plastic forming a colored plastic container. Figure 11 is a front elevational view showing an embodiment of a colored plastic container. Figure 12 is a side elevational view of the colored plastic container of Figure 11; Figure 13 is a plan view of the colored plastic container shown in Figure 11. Figure 14 is a bottom plan view of the colored plastic container shown in Figure π. Figure 15 is a side cross-sectional view of the colored plastic container shown in Figure 11. [Description of main component symbols] ❹ 10 Plastic ampule 11 ' 111 Chemical solution housing 11 a, 111 a Open end 12, 112 Chemical liquid discharge cylinder 13 , 113 Top 14 , 114 Fragile 15 , 115 Center shaft 16 , 116 Bottom 17 ' 117 Shoulder 18 , 104 Intermediate layer 19 Inner layer 20 Outer layer 21 ' 22 Adhesive layer 23 , 123 24 , 25 , 124 , 125 of the liquid medicine receiving part Flange 26 , 126 Liquid discharging cylinder part 97110774 82 200940046 27 ' 127 Top outer surface 28, 128 29 29, 32, 129, 132 flat portion - 30, 33, 130, 133 chamfered portion, 31 '131 reinforcing sheet 101 colored layer 102 cyclic olefin polymer layer 103, 105, 106 Polyolefin Layer® 110 Colored Plastic Ampoule 97110774 83
Claims (1)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006262842 | 2006-09-27 | ||
JP2006346452 | 2006-12-22 | ||
JP2007247703A JP5078523B2 (en) | 2006-09-27 | 2007-09-25 | Plastic ampules |
JP2007330744A JP5078594B2 (en) | 2006-12-22 | 2007-12-21 | Colored plastic containers |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200940046A true TW200940046A (en) | 2009-10-01 |
TWI425941B TWI425941B (en) | 2014-02-11 |
Family
ID=44867879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW97110774A TWI425941B (en) | 2006-09-27 | 2008-03-26 | Plastic ampoules and colored plastic containers |
Country Status (1)
Country | Link |
---|---|
TW (1) | TWI425941B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI615139B (en) * | 2013-06-07 | 2018-02-21 | 細川洋行股份有限公司 | Film for infusion bag and infusion bag using the film |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3219958B2 (en) * | 1995-01-13 | 2001-10-15 | 大日精化工業株式会社 | Colored resin composition for infusion bags |
WO2004093775A1 (en) * | 2003-04-23 | 2004-11-04 | Otsuka Pharmaceutical Factory, Inc. | Drug solution filling plastic ampoule and process for producing the same |
-
2008
- 2008-03-26 TW TW97110774A patent/TWI425941B/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI615139B (en) * | 2013-06-07 | 2018-02-21 | 細川洋行股份有限公司 | Film for infusion bag and infusion bag using the film |
US10172764B2 (en) | 2013-06-07 | 2019-01-08 | Hosokawa Yoko Co., Ltd. | Infusion bag film and infusion bag using infusion bag film |
Also Published As
Publication number | Publication date |
---|---|
TWI425941B (en) | 2014-02-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2266521B1 (en) | Plastic ampule | |
CN101917991B (en) | Plastic container having cyclic polyolefin layer | |
JP5078523B2 (en) | Plastic ampules | |
KR20160013067A (en) | Light-shielding sheet and container | |
JP7240435B2 (en) | Laminates and containers | |
JP5314972B2 (en) | Multilayer film and drug container using multilayer film | |
TW200940046A (en) | Plastic ampule | |
WO2019151532A1 (en) | Laminate, and plastic container | |
JP7184080B2 (en) | Laminates, containers and infusion bags | |
CN102836066B (en) | Plastic ampoule and colored plastic container | |
JP2023148790A (en) | Laminate and plastic container | |
JP2023066723A (en) | Laminate and plastic container | |
JP4016049B2 (en) | Medical multi-chamber container | |
JP2013074928A (en) | Plastic vial | |
JP2023066722A (en) | Laminate and plastic container | |
JP2022062541A (en) | Transparent moisture-absorbing film | |
JP2024509304A (en) | Flexible multilayer film with high low temperature impact strength for medical packaging | |
JP2017093861A (en) | Method for manufacturing sterilized medical multi-chamber container |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |