TW200846026A

TW200846026A - Nanocomposite pigments in a topical cosmetic application

Info

Publication number: TW200846026A
Application number: TW096148097A
Authority: TW
Inventors: Prithwiraj Maitra; John C Brahms
Original assignee: Avon Prod Inc
Priority date: 2006-12-20
Filing date: 2007-12-14
Publication date: 2008-12-01
Also published as: WO2008079760A3; WO2008079760A2; AR064461A1

Abstract

The present invention relates to nanocomposite pigments and methods for treating and improving the aesthetic appearance of a biological surface by altering the optical properties of the biological surface, thereby resulting in a natural appearance. The compositions of the invention may be topically applied to the biological surface, including but not limited to skin, in an amount effective in improving the aesthetic and natural appearance of the biological surface.

Description

200846026 九、發明說明：【發明所屬之技術領域】本發明大體而言係關於化妝品、皮膚及醫藥組合物及其用途’且更詳言之，係關於化妝品組合物及其在改善生物表面之外觀中之用途。【先前技術】在化妝品工業中對開發可局部施用於皮膚以改善皮膚外觀如此皮膚具有自然外觀之產品存在日益增加之需要。理想地’諸如皮膚之生物表面應具有顏色均一之半透明外觀，光滑且平滑之表面，無明顯缺陷。消費者關注減緩或延遲年齡或激素老化或光老化皮膚之皮膚學病徵，諸如細紋、皺紋、乾燥及皮膚下垂及其他歸因於皮膚基質進行性變性之病狀，以及關注改善由包括陽光、污染物、煙霧等之環i兄因素所損害之皮膚外觀。因此，對有助於產生無瑕自然外觀之化妝品存在需要。難以達成完美無瑕且自然之外觀，因為提供所要顏色及覆蓋之化妝品成分通常為不透明的，從而掩蓋皮膚之活力及自然半透明性。雖然可利用較不透明之顏料或粒子，但其不提供遮蔽或掩飾包括皮膚之生物表面之内或之上的瑕疵之足夠覆蓋。化妝品成分可停留於細紋及皺紋中，突出皮膚表面上之瑕疵及缺陷，產生不平滑且不自然之外觀。因此，仍對傳達消費者之皮膚具有較少皺紋及缺陷之感覺的化妝品調配物及製劑存在需要，其藉由允許最佳光折射及光反射且增加光漫射來實現前述情形。 127314.doc 200846026 目前，高效模糊細紋及皺紋以及提供覆蓋變色、老人斑及斑點以匹配年輕皮膚之自然外觀之膚色的所需遮蔽的局部皮膚產品及彩妝產品中存在技術差距。光學降低細紋及皺紋之傳統方法包括在皮膚上產生模糊或柔焦效應或藉由用在面部產生不自然塗層之不透明顏料覆蓋細紋及皺紋。此外，當傳統無機化妝品顏料連同柔焦填充劑一起添加時，模糊效應減弱且塗層產生不透明、蒼白色且不自然之外觀。對組合物及使用其改善皮膚之美學外觀之方法存在需要。因此’提供具有均一顏色、光滑且平滑生物表面而無明顯缺陷之半透明外觀之安全且有效的組合物對包括皮膚之生物表面之治療劑及產品的調配而言將為有利的。【發明内容】本發明之一目#在於提供一種#送於可接受媒劑或載劑中之足以改變生物表面之外觀的有效量之奈米複合顏料的組合物，其中該組合物控制侧向光漫射。在本發明之另一目標中，使化妝品顏料塗佈有奈米粒子。化妝品顏料核心及奈米粒子外殻物質各自可且有不同折射率以控制光漫射性質。顏料核心之折射率大於外殼: 奈米粒子外殼物質之折射率以獲得最佳側向光漫射。在又一目標中，提供一種製造奈米複合顏料之方法。本發月之另-目標在於提供具有核心及外殼之奈米複合 =料’其在皮膚上進_步產生獨特之光學效應。在又—目 ‘中提供一種改善生物表面之美學或自然外觀之方法， 127314.doc 200846026 其係藉由向該生物表面施用可有效改善生物表面之美學或自然外觀之量的具有奈米複合顏料及載劑之組合物而= 成。施用該組合物，如此減弱損害或年齡或激素老化或光老化皮膚之皮膚學病徵之外觀，諸如細紋、皺紋及皮声下 . 垂、表面缺陷及變色。或者，該組合物可在牙齒應用中局部使用以矯正牙齒之顏色或改善牙齒之外觀。本發明之該等及其他目標及優點及其等效物係由具有奈 _ 米複合顏料及其組合之組合物及使用該等局部施用之奈米複合顏料以改善包括（例如）皮膚之生物表面之美學及自然外觀的方法達成。【實施方式】根據丽述目標及本文詳述之其他細節，本發明藉由提供奈米複合顏料組合物及改善由（例如）生物表面之年齡老化過程環境損害或自然缺陷所產生之生物表面的美學外觀之了接受的媒劑克服與先前技術相關之缺點。奈米複合顏 _ 料組合物及其方法，一旦施用於生物表面或合成生物表面，就藉由增強漫射透射及反射性質改變生物表面之外觀來增強表面外觀，從而改善生物表面之美學外觀。包括、（但不限於）角質組織、皮膚、毛髮及指甲之生物表面之美、學外觀可藉由每日或當想要自然外觀時向生物表面局部施用本發明組合物來達成。本發明之奈米複合顏料改變化妝品組合物之光學性質以提供遮蔽、不透明性及覆蓋。奈米複合顏料包含塗佈或包展有奈米粒子外殼之化妝品顏料核心。化妝品組合物中所 127314.doc 200846026 存在之奈米複合顏料適於局部皮膚應用。如本文所使用之術語”奈米粒子（nanoparticle)，，係指奈米尺度之粒子，其具有約！奈米與約500奈米之間的直徑；如本文所使用之術語 "奈米粒子集（nanoparticles)”係指奈米尺度之粒子、奈米簇、簇、粒子、小粒子及奈米結構物質。適於本發明之核心之顏料的粒度在約〇 3微米至約⑺微米範圍内。核心顏料粒度更佳在約〇·3微米至約2微米範圍内。本發明中使用之較佳無機帛料為㈣通常用於個人護理或化妝品工業以提供遮蔽、覆蓋及/或顏色之顏料。在本發明之一實施例中，核心顏料物質為約〇·5微米；在本發明之另一實施例中，核心顏料物質為約1〇微米。提及核心或奈米粒子之大小意謂核心或奈米粒子之最大直線尺寸之長度。舉例而言，球形核心之大小為其直徑，且球形奈米粒子之大小為其直徑。核心顏料之折射率可為約1>38至約3 52;更佳為w 4〇至約3.50 ;更佳為約！ 42至約3 4 ;更佳為約丄6至約3 *，且尤其為約1.8至2.9。該折射率範圍内之顏料包括（但不限 =)二氧化鈦（金紅石或銳鈦礦）、氧化辞及氧化鐵。各種物質之折射率可使用折射計評估。關於折射原理之細節可見於Eugene Hecht之0ptics(第四版），2002。關於物質之折射率之細節可見於CRC Handb00k of Chemistry and，第86版，2005_2〇〇6,其整體以引用之方式併入本文中。在本發明之一實施例中，核心顏料物質為折射率為約2.$ 之一乳化欽（銳欽礦）。 127314.doc 200846026 合適的無機顏料包括（但不限於）二氧化鈦、氧化锆及氧化鈽以及氧化鋅、氧化鐵、氧化鉻、群青及鐵藍。合適的有機顏料包括（但不限於）碳黑及鋇色澱、锶色澱、鈣色澱及銘色殿。可使用產生最佳效果之本發明組合物之任何顏料物質，其非限定性實例包括金屬氧化物，例如二氧化鈦、氡化鐵及氧化鋁；就化妝品工業中使用之典型顏料而口參考 C〇smetic，Toiletry，and Fragrance Association200846026 IX. INSTRUCTIONS OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention relates generally to cosmetic, dermoal, and pharmaceutical compositions and uses thereof, and more particularly to cosmetic compositions and their use in improving the appearance of biological surfaces. Use in the middle. [Prior Art] There is an increasing need in the cosmetics industry to develop products which can be topically applied to the skin to improve the appearance of the skin so that the skin has a natural appearance. Ideally, surfaces such as skin should have a uniform, semi-transparent appearance, a smooth and smooth surface with no visible defects. Consumers are concerned with slowing or delaying dermatological signs of age or hormonal aging or photoaging skin, such as fine lines, wrinkles, dryness and sagging skin, and other conditions attributed to progressive degeneration of the skin matrix, as well as attention to improvement by including sunlight, The appearance of the skin damaged by the pollutants, smoke, etc. Therefore, there is a need for a cosmetic that contributes to the appearance of a flawless natural appearance. It is difficult to achieve a flawless and natural appearance, as the cosmetic ingredients that provide the desired color and coverage are often opaque, thereby masking the vitality and natural translucency of the skin. While less opaque pigments or particles may be utilized, they do not provide sufficient coverage to mask or mask the imperfections within or on the surface of the skin including the skin. Cosmetic ingredients can stay in fine lines and wrinkles, highlighting flaws and defects on the surface of the skin, resulting in an unsmooth and unnatural appearance. Accordingly, there remains a need for cosmetic formulations and formulations that convey less sensation of wrinkles and defects in the skin of the consumer by allowing for optimal light refraction and light reflection and increased light diffusion. 127314.doc 200846026 There is currently a technical gap in high-efficiency blurring of fine lines and wrinkles and in the provision of masking of local skin products and make-up products that provide discoloration, age spots and spots to match the natural appearance of young skin. Conventional methods of optically reducing fine lines and wrinkles include blurring or soft focus effects on the skin or covering fine lines and wrinkles by opaque pigments which produce an unnatural coating on the face. Furthermore, when conventional inorganic cosmetic pigments are added together with a soft focus filler, the blurring effect is diminished and the coating produces an opaque, pale and unnatural appearance. There is a need for compositions and methods of using them to improve the aesthetic appearance of the skin. Thus, it would be advantageous to provide a safe and effective composition that provides a translucent appearance with a uniform color, a smooth and smooth biological surface without significant defects, and for the formulation of therapeutic agents and products comprising biological surfaces of the skin. SUMMARY OF THE INVENTION One aspect of the present invention is to provide a composition of an effective amount of a nanocomposite pigment that is delivered to an acceptable vehicle or carrier sufficient to alter the appearance of the biological surface, wherein the composition controls lateral light. diffusion. In another object of the invention, the cosmetic pigment is coated with nanoparticle. The cosmetic pigment core and the nanoparticle shell material each may have different refractive indices to control light diffusion properties. The refractive index of the pigment core is greater than that of the outer shell: the refractive index of the outer shell material of the nanoparticle to obtain the best lateral light diffusion. In yet another object, a method of making a nanocomposite pigment is provided. Another month of this month is to provide a nanocomposite with a core and a shell that produces a unique optical effect on the skin. Providing a method for improving the aesthetic or natural appearance of a biological surface, in addition, to 127314.doc 200846026 by applying to the biological surface a nanocomposite pigment effective to improve the aesthetic or natural appearance of the biological surface And the composition of the carrier = =. The composition is applied to thereby attenuate the appearance of dermatological signs of damage or age or hormonal aging or photoaging skin, such as fine lines, wrinkles and skin sounds, drooping, surface defects and discoloration. Alternatively, the composition can be used locally in dental applications to correct the color of the teeth or to improve the appearance of the teeth. These and other objects and advantages of the present invention, and equivalents thereof, are obtained from compositions having nano-composite pigments and combinations thereof, and the use of such locally applied nanocomposite pigments to improve biological surfaces including, for example, skin. The method of aesthetics and natural appearance is achieved. [Embodiment] The present invention provides a nanocomposite pigment composition and an improved surface of a biological surface produced by environmental damage or natural defects of, for example, a biological surface ageing process, according to the objectives of the reference and other details detailed herein. Aesthetically accepted acceptable media overcomes the shortcomings associated with prior art. The nanocomposite composition and method, once applied to a biological surface or a synthetic biological surface, enhances the appearance of the surface by enhancing the appearance of the biological surface by enhancing the diffuse transmission and reflection properties, thereby improving the aesthetic appearance of the biological surface. The beauty of the biological surface including, but not limited to, keratinous tissue, skin, hair and nails can be achieved by topical application of the compositions of the invention to the biological surface daily or when a natural appearance is desired. The nanocomposite pigments of the present invention modify the optical properties of the cosmetic composition to provide masking, opacity and coverage. The nanocomposite pigment comprises a cosmetic pigment core coated or encased in a nanoparticle shell. 127314.doc 200846026 The presence of nanocomposite pigments is suitable for topical skin applications. The term "nanoparticle" as used herein, refers to a nanometer-sized particle having a diameter between about ! nanometers and about 500 nanometers; as used herein, the term "nanoparticles "Nanoparticles" means particles of nanometer scale, nanoclusters, clusters, particles, small particles, and nanostructured materials. Pigments suitable for the core of the present invention have a particle size in the range of from about 3 microns to about (7) microns. The core pigment preferably has a particle size in the range of from about 3 micrometers to about 2 micrometers. Preferred inorganic tanning materials for use in the present invention are (iv) pigments which are commonly used in the personal care or cosmetic industry to provide masking, coverage and/or color. In one embodiment of the invention, the core pigment material is about 5 microns; in another embodiment of the invention, the core pigment material is about 1 inch. Mention that the size of the core or nanoparticle means the length of the largest linear dimension of the core or nanoparticle. For example, the size of the spherical core is its diameter, and the size of the spherical nanoparticle is its diameter. The core pigment may have a refractive index of from about 1 > 38 to about 3 52; more preferably from w 4 至 to about 3.50; more preferably about! 42 to about 3 4 ; more preferably from about 6 to about 3 *, and especially from about 1.8 to 2.9. Pigments within this range of refractive indices include, but are not limited to, titanium dioxide (rutile or anatase), oxidized words, and iron oxides. The refractive index of various materials can be evaluated using a refractometer. Details on the principle of refraction can be found in Eugene Hecht's 0ptics (fourth edition), 2002. Details regarding the refractive index of the material can be found in CRC Handb00k of Chemistry and, 86th edition, 2005_2〇〇6, which is incorporated herein by reference in its entirety. In one embodiment of the invention, the core pigment material is one of emulsified Chin (Ruiqin) having a refractive index of about 2. 127314.doc 200846026 Suitable inorganic pigments include, but are not limited to, titanium dioxide, zirconium oxide and cerium oxide, as well as zinc oxide, iron oxide, chromium oxide, ultramarine blue and iron blue. Suitable organic pigments include, but are not limited to, carbon black and strontium lakes, strontium lakes, calcium lakes, and halls of color. Any pigment material of the composition of the invention which produces the best results can be used, non-limiting examples of which include metal oxides such as titanium dioxide, iron telluride and aluminum oxide; for the typical pigments used in the cosmetic industry, the oral reference is C〇smetic ,Toiletry,and Fragrance Association

(CTFA)公開之 International c〇smetic ㈣代心加 Dicti_w and Handbook，第 10版（2〇〇4)(INCI)。適合用作本發明之核心之有機及無機顏料大體上可為固體或具多孔性。在-實施例中，核心顏料之外表面大體上為固體且具有均-輪廓。在另—實施例中，核心顏料之外表面八有夕孔性。適合用作本發明之核心之有機及無機顏料大體上可為球形、圓柱形、橢球形、小板形，或形狀可為多面的或不規則的。在—實施例中，核心顏料大體上為球形。在另—實施财，核心顏料具有橢球之形狀。在另 -實施例中，核心顏料為立方形。在另一實施例中，核心顏t具有小板之形狀。在另-實施例中，核心顏料不規則且非對稱地成形。 ' 適於本發明之外殼之奈米粒太丰·舌^于之大小在約1奈米至約500 不未，更佳約7奈米至約3〇〇奈米· 奈米之範圍内。包含本發明、、’丁…卡至約200 匕3本么明之奈米複合顏料之 iT平均粒度之大小在約1奈米至請奈米;更= 約3°〇奈米；更佳約1〇奈米至约奈米之範圍内。 127314.doc 200846026 在本發明之一實施例中，奈米粒米。在本發明之一容浐彻由長初始粒度為約7奈發明…施二T 粒子為約20奈米。在本 4例中’奈米粒子為約50奈米。在本發明之一貝鉍例中，奈米粒子為約100奈米。之=發Γ::實施例中，外殼之奈米粒子小於核心顏料 #明之另—實施例中’外殼之奈米粒子盘核小大致相同。外殼之奈米粒子較佳小於核心顏料(CTFA) published by International c〇smetic (4) on behalf of the heart and Dicti_w and Handbook, 10th edition (2〇〇4) (INCI). Organic and inorganic pigments suitable for use as the core of the present invention can be substantially solid or porous. In an embodiment, the outer surface of the core pigment is substantially solid and has a uniform-contour. In another embodiment, the outer surface of the core pigment has a porch. Organic and inorganic pigments suitable for use as the core of the present invention may generally be spherical, cylindrical, ellipsoidal, platelet shaped, or may be multifaceted or irregular in shape. In the embodiment, the core pigment is substantially spherical. In another implementation, the core pigment has the shape of an ellipsoid. In another embodiment, the core pigment is cuboid. In another embodiment, the core face t has the shape of a small plate. In another embodiment, the core pigment is shaped irregularly and asymmetrically. The nanoparticle suitable for the outer shell of the present invention is in the range of from about 1 nm to about 500, more preferably from about 7 nm to about 3 nm. The iT average particle size of the nano-composite pigment comprising the present invention, the 'd... card to about 200 匕 3 么明在纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米From the range of 〇nami to Jonami. 127314.doc 200846026 In one embodiment of the invention, nanoparticle. In one aspect of the present invention, the initial particle size is about 7 nanometers. The invention has two T particles of about 20 nm. In the 4 cases, the 'nano particles are about 50 nm. In one of the examples of the present invention, the nanoparticles are about 100 nm. = Hair: In the embodiment, the nanoparticle of the outer shell is smaller than the core pigment. In the embodiment, the nanoparticle disk core of the outer shell is substantially the same. The nanoparticle of the outer shell is preferably smaller than the core pigment

、二•明之奈米粒子包括(但不限於)由煙霧狀二氧化石、-屬乳化物(諸如，氧化銘、氧化辞、二氧化欽或氧 )氣成之奈米粒子；或聚合奈米粒子，諸如聚（甲基丙烯酸甲酉旨KPMMA)、耐綸、聚乙婦_、聚苯乙稀㈣、 3.5，孓佳為約i.4至2 5 ’且更佳為約14至。在本發明之貝靶例中，外破奈米粒子為折射率為約146之煙霧狀氧化石夕I只知例中，外殼可包含具有不同折射率之奈米粒子之組合。聚四氟乙烯或纖維素^ H粒子之折射率可為社％至約核“物貝及外喊奈米粒子能夠改變可見光之散射特性，從而提供適用於掩飾皺紋、細紋或生物表面缺陷之化妝品組合物之柔焦或模糊效應。化妝品顏料核心之折射率與奈米粒子外殼物質之折射率之差可在約〇·2至約2範圍内。在本^明之一貝％例中，化妝品顏料核心之折射率與奈米粒子外殼物質之折射率之差為約！〇。在本發明之另一實施例中’化妝品顏料核心之折射率與奈米粒子外殼物質之折 127314.doc -11- 200846026 射率之差為約0.7。在本發明之另—實施例中，化妝品顏料核心之折射率與奈米粒子外殼物質之折射率之差為約 0.5。使用具有低折射率外殼之高才斤射率核心達成界面處光方向之急劇變化’從而增強光漫射’產生高覆蓋以及模糊效應。光之側向漫射產生模糊效應，其有助於遮蔽皮膚上之細紋及皺紋。使用具有高折射率之核心藉由核心與外殼界面處之光全内反射提供高覆蓋及模糊以及侧向光漫射。當該等奈米複合顏料用於例如粉底之局部化妝品中時，其將對細紋、皺紋及皮膚缺陷具有較高模糊效應。在本發明之貝靶例中，奈米複合顏料之折射率為約2 ;在本發明之另-實施例中，奈米複合顏料之折射率為約2· 19。不米粒子外喊與核心顏料之重量比可在約5%至約％%、更佳約20%至約80%範圍内。重量比決定外殻與核心之相對厚度，從而影響奈米複合顏料之折射率。在本發明之一實靶例中，奈米複合顏料具有4〇重量％ Ti〇2核心及6〇重量 /〇示米尺度煙務狀二氧化矽外殻；在本發明之另一實施例中，奈米複合顏料具有30重量％ ^(^及川重量％奈米尺度煙霧狀二氧化石夕外殼。構成本發明之奈米複合顏料之外殼的奈米粒子之總表面積2可在約20 m2/g至約7〇〇 m2/g、更佳約5〇 m2/g至約5〇〇 m/g、更佳約7〇 m2/g至約4〇〇瓜2^之範圍内。外殼之奈米粒子之總表面積與產生高表面積與體積比之構成外殼之個別奈米粒子的大小以及所利用之奈米粒子的體積相關。因 127314.doc -12- 200846026 此，構成外殻之奈米粒子之總表面積亦可影響奈米複合顏料之折射率。奈米粒子之總表面積支配外殼中光之多次散射。總表面積將確定外殼之密度。總表面積亦將確定個別粒子彼此間之相互作用或外殼奈米粒子與核心之相互作用0 奈米複合顏料可使用美國專利第4,978,483號及美國專利第5,271，881號（其揭示内容以引用之方式併入本文中）中所纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米纳米The particles, such as poly(methyl methacrylate, KPMMA), nylon, polyethylene, styrene, hexanol, hexanol, hexanol In the shell example of the present invention, the outer nanoparticle is a fumed oxide having a refractive index of about 146. In the case of only one example, the outer shell may comprise a combination of nanoparticles having different refractive indices. The refractive index of the polytetrafluoroethylene or cellulose H particles can be from % to about nucleus. The object and the outer nano particles can change the scattering characteristics of visible light, thereby providing a suitable for covering wrinkles, fine lines or biological surface defects. The soft focus or blurring effect of the cosmetic composition. The difference between the refractive index of the core of the cosmetic pigment and the refractive index of the outer shell material of the nanoparticle can range from about 〇·2 to about 2. In one example of the present invention, the cosmetic The difference between the refractive index of the pigment core and the refractive index of the outer shell material of the nanoparticle is about !. In another embodiment of the present invention, the refractive index of the core of the cosmetic pigment and the outer shell of the nanoparticle are 127314.doc -11 - 200846026 The difference in the luminosity is about 0.7. In another embodiment of the invention, the difference between the refractive index of the cosmetic pigment core and the refractive index of the nanoparticle shell material is about 0.5. The core of the core rate reaches a sharp change in the direction of light at the interface 'and thus enhances light diffusion' to produce high coverage and blurring effects. The lateral diffusion of light produces a blurring effect that helps to mask the skin. Fine lines and wrinkles. The use of a core with a high refractive index provides high coverage and blurring and lateral light diffusion by total internal reflection at the interface between the core and the outer shell. When such nanocomposite pigments are used in topical cosmetics such as foundations In the middle, it will have a high blurring effect on fine lines, wrinkles and skin defects. In the shell example of the present invention, the refractive index of the nanocomposite pigment is about 2; in another embodiment of the present invention, The refractive index of the rice composite pigment is about 2.19. The weight ratio of the non-rice particles to the core pigment may range from about 5% to about %%, more preferably from about 20% to about 80%. The relative thickness of the core, thereby affecting the refractive index of the nanocomposite pigment. In one of the practical examples of the present invention, the nanocomposite pigment has 4% by weight of Ti〇2 core and 6〇 weight/〇米米烟a cerium oxide shell; in another embodiment of the present invention, the nanocomposite pigment has 30% by weight (% by weight) and a weight percent nanometer scale smog-like sulphur dioxide shell. The nano-composite pigment constituting the present invention The total surface area of the nanoparticle of the outer shell 2 In the range of from about 20 m2/g to about 7 〇〇m2/g, more preferably from about 5 〇m2/g to about 5 〇〇m/g, more preferably from about 7 〇m2/g to about 4 〇〇2 The total surface area of the nanoparticle of the outer shell is related to the size of the individual nanoparticles constituting the outer shell and the volume of the nanoparticles used to produce the high surface area to volume ratio. 127314.doc -12- 200846026 The total surface area of the shell nanoparticles can also affect the refractive index of the nanocomposite pigment. The total surface area of the nanoparticle dominates the multiple scattering of light in the outer shell. The total surface area will determine the density of the outer shell. The total surface area will also determine the individual particles of each other. Inter-interactions or interactions of the outer shell nanoparticles with the core. 0 The nanocomposite pigments can be used in U.S. Patent No. 4,978,483, and U.S. Patent No. 5,271,881, the disclosure of which is incorporated herein by reference.

述之M-Cap技術及如起始原料之混合時間、溫度及組成之控制參數藉由組合膠囊化方法之凝聚、造粒及喷霧乾燥原理來製備。另夕卜，可使用靜電電荷及/或凡得瓦爾相互作用（van der Waals interaction)將奈米粒子置放於外殼物質中。、奈米複合顏料較佳藉由首先製造包含黏合劑、溶劑、奈米粒子及核心顏料之混合物來製備。隨後向混合物中添加尺乂形成於連績水相中之乳液。懸浮於乳液中之液滴在液滴以及奈米粒子、溶劑及結合聚合物之液體部分中具有核顏料物貝。驅散各液滴中之溶劑，留下固體粒子於水中 2懸子液。該等固體粒子含有核心顏料，其中奈米粒子由。聚口物與核心結合。可使用諸如噴霧乾燥之習知技術移除水，留下奈米複合顏料粉末。不米複合顏料可使用合適的溶劑製備，該等溶劑包如）H (例如，己烷、庚烷、辛烷、壬烷、癸烷、十二十烷等），環烷烴（例如，環戊烷、環己烷等）；芳煙（例如，苯、兑 f本4 )及則述者之混合物。奈米複合顏 127314.doc -13- 200846026 較佳使用諸如環己烷之揮發性溶劑製備。奈米複合顏料可使用各種黏合劑中之任-種製備。黏合劑較佳為聚合黏二劑，包括（但不限於）美國專利第4,978,483號之圖5中二二之彼等黏合劑，例如羧甲基纖維素、聚乙烯醇、聚醯胺、 . 聚氯乙烯、聚胺基甲酸酯、聚甲基丙烯酸甲酯、蠟等。聚 • 合物黏合劑較佳基於其光學特性選擇，更佳黏合劑因為當將其併入奈米複合顏料外殼時，其在光學上至少半透明= 籲 #以選擇° "至少半透明”意謂半透明或透明。透明度為允許光牙過而無顯者散射或模糊之性質。透明物質可看透；亦即，其允許清晰圖像穿過。半透明物質允許光穿過但散射，如此該物質扭曲圖像。如本文所使用，合適的黏合劑允許至少30%、較佳至少5〇%且最佳至少75%之光穿過。較佳可使用三聚氰胺或環氧樹脂聚合物作為聚合物黏合劑。圖1描繪本發明之奈米複合顏料之光漫射性質。光進入 • 自具有低折射率之奈米粒子製成之奈米複合顏料外殻。核心顏料具有比外殼高之折射率。核心與外殼之間的折射率之差將控制核心與外殼之間的界面處之光之總内反射。外 ‘ ㉟奈米纟子及核心顏料之設計及選擇τ增加大於全内反射 t臨界角之人射角，從而增強沿界面之光漫射。使用高表面積粒子增加沿界面之多次散射。藉由使用高折射率核〜，可獲得兩覆盍以及模糊效應。具有低折射率外殻之高折射率核心能夠藉由增加漫射透射使奈米複合顏料產生模糊效應，且從而改善組合物所施用之生物表面之外觀。不 127314.doc -14- 200846026 希望X理淪限制，咸信模糊及柔焦效應之效能或掩飾細紋及皺紋之能力隨漫射透射參數而變（”Quantificati〇n Soft Focus Effect"，Co㈣州以 ά 如/价以 Ul:57, 1996)。因此，產生高漫射透射之任何奈米複合顏料將有利於化妝品調配物或製劑產生模糊效應，改善化妝品所施用之生物表面之自然外觀且克服不透明、不自然且蒼白色之典型化妝品及停留於細紋及皺紋中之化妝品之缺點。本發明組合物之優點包括（但不限於）至少一種奈米複合顏料提供光學模糊及”覆蓋，，而無導致損失柔焦效應之蒼白色殘餘且無意中突出顏料停留於其中之細紋或皺紋之情況的簡單性。諸如PMMA、PE、球形二氧化矽之傳統商業柔焦物質雖然提供軟模糊，但僅具有低折射率，此產生不提供覆蓋之透明薄膜。另外，與球形聚合柔焦物質相比，奈米複合粒子具有更佳且更高效之模糊。若奈米複合顏料極其小，例如小於丨〇〇奈米或約i 〇〇奈米，則可產生亦提供紫外線（UV)防護之膜及塗層。奈米複合顏料之另一優點在於其吸收（例如）油、皮脂及水分。該專性貝在化妝品及皮膚調配物或組合物中提供其他只處，且增強諸如皮膚、嘴唇、毛髮及指甲之生物表面之美學及自然外觀。本發明之另一實施例提供奈米複合顏料組合物，其具有增強生物表面之美學及自然外觀之光學性質，同時減少或消除使用用於覆蓋之傳統顏料或染料，而產生光學模糊及漫射光透射、光散射及反射，從而減少年齡老化、光老 127314.doc •15- 200846026 化、激素老化及/或光化性老化之皮膚學病徵之外觀；減少細紋及/或皺紋之外觀；減小面部細紋及皺紋，面頰、前額上之面部皺紋，眼之間的垂直皺紋、眼上方之水平皺紋及口周圍之皺紋’木偶紋且尤其深皺紋或摺紋之顯著程度；減少細紋及/或皴紋之外觀及/或深度；改善眼眶丁細紋及/或眼眶周圍細紋之外觀；減少魚尾紋（cr〇w，s feet)2 外觀；改善再生及/或新生皮膚之外觀；減少老化皮膚之外觀，減少皮膚脆性之外觀；減少喪失葡糖胺聚糖及/或膠原之外觀；減少***失調之外觀；減少皮膚萎縮之外觀；減少色素過多之外觀；減少皮膚變色之外觀；改盖膚色、光彩、透明度及/或繃緊度之外觀；減少下垂皮膚二外觀；改善皮膚緊實度、飽滿度、柔韌度及/或柔軟^之外觀；改善原膠原及/或膠原產生之外觀；改善皮膚紋理及/或重織構化之外觀；改善皮膚屏障修復及/或功能之外觀；改善皮膚輪廓之外觀；改善皮膚光澤及/或亮度降低之外觀；改善疲勞及/或壓力之皮膚學病徵之外觀；改善環境壓力之外觀；改善細胞老化之外觀；改善皮膚脫权外觀，改善彈性及/或回彈性皮膚 . ^ Γ规，改善微循環之外觀；減少形成皮下脂肪之外觀；或其任何組合。本發明之另一實施例係關於一種改善生物表二之t法’其包含向包括(但不限於)角質組織：皮 :”外及•曰甲之生物表面施用可有效改善生物表面美學或自；、、、、外觀之量的具有本文所述、、—人紅荷倣及性質之包含太芈複a顏料的本發明組合物。不未 127314.doc •16- 200846026 使角質表面與包含奈米複合顏料之本發明組合物接觸使得在角質表面上形成膜，其中該膜產生模糊效應，改善角質表面之自然外觀。The M-Cap technique and control parameters such as mixing time, temperature and composition of the starting materials are prepared by agglomeration, granulation and spray drying of the combined encapsulation process. In addition, the nanoparticle can be placed in the outer shell material using electrostatic charge and/or van der Waals interaction. Preferably, the nanocomposite pigment is prepared by first producing a mixture comprising a binder, a solvent, nanoparticles, and a core pigment. An emulsion of the ruler formed in the continuous aqueous phase is then added to the mixture. The droplets suspended in the emulsion have a nuclear pigment in the liquid droplets as well as in the liquid portion of the nanoparticles, the solvent and the bound polymer. Disperse the solvent in each droplet, leaving the solid particles in water 2 suspension. The solid particles contain a core pigment from which the nanoparticles are composed. The poly-mouth is combined with the core. The water can be removed using conventional techniques such as spray drying to leave the nanocomposite pigment powder. The non-rice composite pigment can be prepared using a suitable solvent such as H (for example, hexane, heptane, octane, decane, decane, decanede, etc.), a cycloalkane (for example, cyclopentane). Alkane, cyclohexane, etc.); aromatic smoke (for example, benzene, f. 4) and mixtures thereof. Nanocomposite 127314.doc -13- 200846026 is preferably prepared using a volatile solvent such as cyclohexane. The nanocomposite pigment can be prepared using any of various binders. Preferably, the binder is a polymeric binder comprising, but not limited to, the binders of the second of the second of the U.S. Patent No. 4,978,483, such as carboxymethylcellulose, polyvinyl alcohol, polyamine, poly. Vinyl chloride, polyurethane, polymethyl methacrylate, wax, and the like. The polymeric binder is preferably selected based on its optical properties, and the better binder is optically at least translucent when it is incorporated into the nanocomposite pigment shell = ## to select ° "at least translucent" It means translucent or transparent. Transparency is the property of allowing the teeth to be scattered or blurred. The transparent substance can see through; that is, it allows clear images to pass through. Translucent substances allow light to pass through but scatter, so The substance distorts the image. As used herein, a suitable binder allows at least 30%, preferably at least 5%, and optimally at least 75% of the light to pass through. Preferably, a melamine or epoxy polymer can be used as the polymerization. Figure 1 depicts the light diffusing properties of the nanocomposite pigments of the present invention. Light enters • A nanocomposite pigment shell made of nanoparticles with a low refractive index. The core pigment has a higher refractive index than the outer shell. Rate. The difference in refractive index between the core and the outer shell will control the total internal reflection of light at the interface between the core and the outer shell. The design and selection of the outer '35 nm tweezers and core pigments τ increases more than total internal reflection. The angle of incidence of the critical angle, thereby enhancing light diffusion along the interface. The use of high surface area particles increases multiple scattering along the interface. By using a high refractive index core ~, two coverages and blurring effects can be obtained. The high refractive index core of the rate shell can impart a hazy effect to the nanocomposite pigment by increasing the diffuse transmission, and thereby improve the appearance of the biological surface to which the composition is applied. 127314.doc -14- 200846026 The effectiveness of the ambiguity and soft focus effect or the ability to mask fine lines and wrinkles varies with the diffuse transmission parameters ("Quantificati〇n Soft Focus Effect", Co (4) states ά as / price to Ul: 57, 1996). Thus, any nanocomposite pigment that produces high diffuse transmission will facilitate the blurring effect of cosmetic formulations or formulations, improve the natural appearance of the bio-surface to which the cosmetic is applied, and overcome the opaque, unnatural and pale typical cosmetics and stay in The shortcomings of cosmetics in fine lines and wrinkles. Advantages of the compositions of the present invention include, but are not limited to, at least one nanocomposite pigment providing optical blurring and "covering" without the pale residue of the soft focus effect and inadvertently highlighting the fine lines or wrinkles in which the pigment resides. The simplicity of the situation. Conventional commercial soft-focus substances such as PMMA, PE, spherical cerium oxide, while providing soft blur, have only a low refractive index, which produces a transparent film that does not provide coverage. In addition, with spherical polymeric soft-focus substances In contrast, nanocomposite particles have better and more efficient blur. If the nanocomposite pigment is extremely small, such as less than 丨〇〇 nanometer or about i 〇〇 nanometer, it can produce a film that also provides ultraviolet (UV) protection. And coatings. Another advantage of nanocomposite pigments is that they absorb, for example, oil, sebum, and moisture. The obligate shell provides other nuances in cosmetic and dermal formulations or compositions, and enhances such as skin, lips, Aesthetic and natural appearance of the biological surface of hair and nails. Another embodiment of the present invention provides a nanocomposite pigment composition having an enhanced biological surface The aesthetics and the optical properties of the natural appearance, while reducing or eliminating the use of traditional pigments or dyes used for covering, resulting in optical blurring and diffuse light transmission, light scattering and reflection, thereby reducing ageing, aging 127,314.doc •15- 200846026 Appearance of dermatological signs of oxidative, hormonal aging and/or actinic aging; reduction of appearance of fine lines and/or wrinkles; reduction of fine lines and wrinkles on the face, facial wrinkles on the cheeks, forehead, between the eyes Vertical wrinkles, horizontal wrinkles above the eyes, and wrinkles around the mouth. The degree of puppetry and especially deep wrinkles or creases; reduced appearance and/or depth of fine lines and/or crepe; improved fine lines and/or The appearance of fine lines around the eyelids; reducing the appearance of crows (s feet) 2; improving the appearance of regenerated and/or newborn skin; reducing the appearance of aging skin, reducing the appearance of skin fragility; reducing loss of glycosaminoglycans and / or the appearance of collagen; reduce the appearance of estrogen imbalance; reduce the appearance of skin atrophy; reduce the appearance of hyperpigmentation; reduce the appearance of skin discoloration; change the complexion, radiance The appearance of transparency and/or tightness; reduces the appearance of sagging skin; improves skin firmness, fullness, flexibility and/or softness; improves the appearance of procollagen and/or collagen; improves skin texture and / or retextured appearance; improved appearance of skin barrier repair and / or function; improved appearance of skin contour; improved skin gloss and / or reduced brightness appearance; improved appearance of fatigue and / or pressure dermatological symptoms; Improve the appearance of environmental stress; improve the appearance of cell aging; improve the appearance of skin distraction, improve elasticity and / or resilience skin. ^ Γ regulations, improve the appearance of microcirculation; reduce the appearance of subcutaneous fat; or any combination thereof. Another embodiment of the invention relates to a method for improving the biological surface of a biological method, which comprises applying, but not limited to, keratinous tissue: skin: "outside and" armor, the surface of the organism can effectively improve the aesthetics of the biological surface or self; An amount of the composition of the present invention comprising an anthraquinone a pigment having the properties described herein, and having a human red imitation and properties. No. 127314.doc •16- 200846026 Contacting the keratinous surface with a composition of the invention comprising a nanocomposite pigment results in the formation of a film on the keratinous surface wherein the film produces a hazy effect that improves the natural appearance of the keratinous surface.

生物表面可為通常施用化妝品、個人護理產品、皮膚組合物及醫藥組合物之任何表面，包括（但不限於）皮膚、嘴唇、毛髮、指甲及其類似物。施用於生物表面之組合物藉由掩飾生物表面之自然老化過程、變色、慢性及累積性損害及表面上之缺陷而改善或增強皮膚之美學外觀。本發明之實施例係關於發現組合物或調配物中之奈米複合顏料掩飾歸因於老化之細紋、皺紋、毛孔、下垂或其他病狀。因此，依本發明組合物之光學性質而定，能夠掩飾生物表面老化、皮膚學變性之病徵及生物表面之缺陷，從而改善皮膚之美學及自然外觀。本發明之一實施例係關於將奈米複合顏料組合物施用於皮膚之叉影響區之方法。較佳至少一日一次、較佳一天兩次局部施用組合物，且使組合物保持在皮膚之受影響區，其中皮膚之受影響區包括（但不限於）面部、頸部、腿及大腿、頭皮及全身。可根據特定方案施用組合物，例如，每日施用歷時-週、兩週或兩週以上，或可能設計為持續每曰使用。本發明之化裝組合物亦可設計為使用—段時間後取消，當想要時，再施用。局部組合物較佳具有改：膚、尤其老化及/或發炎皮膚之化妝及/或美學外奈米複合顏料。在另一實施例中，該組合物可具有基於組合物之總重量 127314.doc -17· 200846026 计約Ο」％至約5〇%、較佳約〇.5%至約2〇%、更佳約ι%至約 10%之量的奈米複合顏料物質，#中該 (例如)皮膚之自然及美學之外觀。改。奈米複合顏料組合物當施用、較佳以每曰施用之方式局部施用於生物表面時’可用於改善包括皮膚、嘴唇、毛髮及扣甲之生物表面之自然及美學之外觀。除載劑或媒劑外，本發明之組合物亦可包括可用於減少、減弱或掩飾與生物表面之老化、發炎及變性相關之醫學及/或化妝品病狀之活性成分的非限^性實例。如本文所使用，該等病狀通常包括（但不限於）皮膚老化（年齡老化、激素老化及/或光化性老化）、皮炎、皮膚及毛髮脆性、多毛症、紅斑痤瘡、皮膚斑點、敏感皮膚、色素過度或色素不足、皮膚菲薄、粗糙、角化、皮膚萎縮、皺紋、細紋、增生、纖維化及其任何組合。本發明之活性組分亦可用於增強皮膚之_ 般健康狀況、生命力、狀況及美學外觀。根據本發明，包含具有想要性質之奈米複合顏料之組合物可用於局部施用調配物、抗氧化劑、抗發炎劑、防曬劑、化妝品（包括化裝用品）及減少老化之皮膚病征（包括皺紋、細紋及皮膚下垂及其類似者）之調配物。同樣，根據本發明，組合物中之其他組分可以各種產品形式調配。該荨組合物可以乾傳送糸統製備’例如乳霜、洗劑、增濕劑、凝膠、調色劑、漿液、噴霧、泡沫、散劑及其類似物，尤其用於局部施用及投藥。本發明進一步提供包含奈米複合顏料之組合物，較佳用 127314.doc -18 - 200846026 於局部投藥或乾向傳送而不誘發明顯刺激。本發明組合物 j於所有皮膚類型’諸如敏感性、中性、乾性或油性，較 ’子乾!·生皮膚以及成熟皮膚敏感。在特定實施例中，該等組合物可能適於乾性皮膚。組合物施用於皮膚歷時一段足 • ^日強皮膚之自然及美學外觀的時間、组合物可每日一 :欠、兩次或兩:欠以上局部_於生物表面，該等生物表面包括（但不限於）皮膚、嘴唇及毛髮。 • 、局部組合物可調配於脂質體中，該等脂質體可包含其他 ’小加d或物質及/或更特定而言其可經改質以在投藥後到達或分留在某-位點。本發明之實施例之組合物藉由掩飾或文口至 >、一種先如所述之病狀或其組合產生對皮膚之美學外觀之改善。 ' 從業者應瞭解，包含奈米複合顏料之化妝品治療可(例如）藉由根據投與該等組合物之常規技術局部施用如本文所述之化妝品組合物來進行。局部化妝品、皮膚或醫藥組 • 合物較佳每日施用一次歷時至少1週之時間，但可包括約2 週、4週、8週、12週或12週以上之時間。化妝品組合物較佳施用於面部及頸部，但亦可施用於需要美學改善之皮膚之任何區域，其中化妝品組合物停留在皮膚之受影響區， • 且較佳不自皮膚移除或洗除。常規及通常實施之技術涵蓋向皮膚施用乳霜、洗劑、凝膠、漿液、軟膏 '化裝用品、防曬組合物或其類似物。該化妝品組合物較佳為局部停留調配物’其中亦預想喷霧作為施用形式。本發明之另一實施例涵蓋組合物，其包含適於與包括人 127314.doc -19- 200846026 類組織之活哺乳動物組織或其合成等效物接觸而幾乎不對使用者產生不利生理效應之化妝品學上、皮膚學上或醫荜學上可接受之奈米複合顏料調配物。本發明所包括之組合物可以任何化妝品學及/或皮膚學上合適的形式、較佳洗劑或乳霜形式、以及於無水或含水基質中之形式以及可噴灑液體开》式提供。本發明之組合物之其他合適的化妝產品形式包括（但不限於）（例如）乳液、乳霜、膏、唇彩、洗劑、泡沫 '面膜、漿液、調色劑、軟膏、慕斯（m〇usse)、貼片、髮膏、溶液、喷霧、蠟基棒（wax_based stick)或濕巾。另外，本發明所涵蓋之組合物可包括一或多種熟習此項技術者通常使用且瞭解之相容性化妝品上可接受之佐劑，諸如芳香劑、潤膚劑、保濕劑、防腐劑、維生素、螯合劑、增稠劑、紫蘇油或紫蘇子油（W〇〇1/66〇67， ’’Method of Treating a Skin c〇ndhi〇n"，併入本文中）及其類似物以及其他植物性藥物’諸如蘆薈、甘菊及其類似物及如以下進一步所述。本發明之奈米複合顏料可含於化妝學上、皮膚學上、生理學上及醫藥學上可接受之媒劑、介質、稀釋劑或載劑中以用於減少、改善或預防生物表面之與老化及發炎相關之皮膚病征。在包括局部施用之_實施例中，本發明之植合物包含與包括皮膚、嘴唇、毛髮及指f之哺乳動物生㈣面相谷之介質（媒劑、稀釋劑或载劑）。該等組合物可以水相、油相、醇或水性/醇基溶液、軟膏、乳霜、洗劑、凝膠、水包壤乳液或具有乳霜或凝膠、微乳液或喷霧劑之外 127314.doc -20- 200846026 觀之油包水乳液、水包油乳液、水-油-水三重乳液形式調配。水相為一或多種水溶性或水可分散成分之混合物，其在室溫（25。〇下可為液體、半固體或固體。媒劑構成於水中之懸浮液、分散液或溶液或呈於水中之懸浮液、分散液或 /谷/夜形式或為水性-醇性媒劑’其可含有增稠劑或豚凝劑。熟習此項技術者可基於熟習此項技術者具有之知識選擇適當的化妝品形式、其中所含之成分以及其製備方法。在一實施例中，該組合物可包括可含有水或水與至少一種親水性有機溶劑之混合物之水相，該有機溶劑尤其為醇’尤其含有2至5個碳原子之線性或分枝低碳一元醇，例如’乙醇或丙醇；多元醇’例如，丙二醇、山梨糖醇、甘油、雙甘油、泛醯醇或聚乙二醇及其混合物。該水相基於組合物之總重量計可佔約0.5重量％至約99.99重量％。在另一實施例中，當本發明之組合物呈乳液形式時，組合物亦可視情況包含基於組合物之總重量計較佳約〇. j重量％至約30重量％且尤其約1重量％至約20重量％之量的界面活性劑。在本發明之另一實施例中，該組合物亦可包含增稠聚合物，諸如兩親媒性聚胺基甲酸酯、聚丙烯酸均聚物或共聚物、聚酯或煙基樹脂。其他非限制性聚合物包括以下各物之均5^物或共聚物·具有1至1 8個碳原子之脂族助劑乙稀 _，諸如乙酸乙烯酯；具有1至18個碳原子之醇之丙烯酸酉旨及甲基丙烯酸酯，諸如丙烯酸曱酯、丙烯酸乙酯、丙烯 127314.doc •21- 200846026 酸丁脂、丙烯酸2-乙基己酯、甲基丙烯酸曱酯、甲基丙烯酸乙酯及甲基丙烯酸丁酯；及單及二烯系不飽和烴：包括乙烯異丁烯、苯乙烯及脂族二烯’包括丁二烯、異戊二稀及氯丁二烯。〃一本發明之一實施例進一步係關於本發明之組合物，其亦可包含含有在室溫（25^)下為液體之油溶性或油可分散成分及/或在室溫下為固體之油狀或蠟狀物質（諸如，蠟、半固體、膠狀物及其混合物）之油相。該油相亦可含有有機溶劑。在室溫下為液體之合適油狀物質，通常稱為油，包括動物來源之烴基油，諸如全氫化角鯊烯；烴基植物油，諸如 4至1〇個碳原子之脂肪酸之液體三酸甘油酯，例如，庚酸或辛酸二酸甘油酯，或油類，諸如向日葵油、玉米油、大旦油、葡萄籽油、蓖麻油、鱷梨油、辛酸/癸酸三酸甘油酉曰街射芭’由（i〇j〇ba oil);礦物或合成來源之線性或分枝烴，諸如液體石蠟及其衍生物、石油膏；合成酯及醚，尤其脂肪醇酯，即（例如）肉豆蔻酸異丙酯、棕櫚酸2_乙基己酯、硬脂酸2-辛基十二烷酯、異硬脂酸異硬脂醯酯；經基化知’諸如乳酸異硬脂酿酯、經基硬脂酸辛酯、經基硬脂酉文辛基十二烷酯、脂肪醇之庚酸酯、辛酸酯及癸酸酯；多疋醇酯，諸如丙二醇二辛酸酯、新戊二醇二庚酸酯、二乙一醇二異壬酸酯及異戊四醇酯；含有12至26個碳原子之脂肪醇，諸如辛基十二烷醇、丁基辛醇、2-己基癸醇、2_ 十一燒基十五烧醇、油醇；部分烴基氟基油及/或氟聚矽 1273l4.doc -22- 200846026 氧由聚⑦氧油冑如揮發性或非揮發性線性或環狀聚雙曱基石夕氡烧（匪s)，其在室溫下為液體或半固體，諸如環甲聚石夕氧燒及二甲聚石夕氧燒(視情況包含苯基，例如苯基Μ Μ氧其混合物。該等油通常以基於油相之重量計約〇重酱。/α $ μ Λ 里T J更里/0至約90重量％、較佳約1重量〇/〇至約80重量％之量存在。本發明之組合物之油相田相亦可包含一或多種化妝品學上可接受之有機溶劑。該等溶劑係以基於組合物之總重量計約 °，1重量％至約80重量％、較佳約!重量。Λ至約50重量％之量存在且可選自由親脂性有機溶劑、兩親媒性有機溶劑及〃此。物組成之群。本發明組合物中可使用之合適溶劑包括乙酸醋，諸如乙酸甲醋、乙酸乙酯、乙酸丁醋、乙酸戊酉旨或乙酸2-甲氧基乙醋、乙酸異丙醋；煙，諸如甲苯、二甲本、、對二甲苯、己燒或庚燒；含有至少3個碳原子之謎及其混合物。本發月之、，’且σ物可進—步包含化妝品領域通常使用之任何成分。該等成分包括㈣劑、水相增稠劑（多醣生物聚合物、合成聚合物）及脂肪相增稠劑、芳香劑、親水性及親脂性活性劑及其混合物。該等各種成分之量為化妝品領域中通常使用以達成苴褶宕曰从曰運庾，、預疋目的之1，且通常在基於組合物之總重量計約(U重量％至約2〇重量％之範圍内。該等成分之性質及其量必須與本發明組合物之製造相容。本發明之組合物亦可包含另一顆粒相，該顆粒相通常以基於組合物之總重量計約〇」重量％至約3〇重量％、較佳约 127314.doc -23- 200846026 〇.5重量％至約20重量％之量存在’且其可包含化妝品組合物中所使用之珠光劑及/或填充劑。合適的珠光劑包括塗佈二氧化鈦或氧化鐵之雲母。填充劑通常以基於組合物之總重量計約〇1重量％至約％重量°/❶、較佳約0.5重量％至約15重量％之量存在。合適的填充劑包括滑石、二氧化石夕、硬脂酸鋅、雲母、高嶺土、耐綸（尤其orgasol)粉末、聚乙烯粉末、Tefl〇_、澱粉、氮化硼、共聚物微球，諸如Expancel®(Nobel Industrie;The biosurface can be any surface to which a cosmetic, personal care product, skin composition, and pharmaceutical composition is typically applied, including but not limited to skin, lips, hair, nails, and the like. Compositions applied to biological surfaces improve or enhance the aesthetic appearance of the skin by masking the natural aging process of the biological surface, discoloration, chronic and cumulative damage, and surface defects. Embodiments of the present invention relate to the discovery that nanocomposite pigments in compositions or formulations mask the fine lines, wrinkles, pores, sagging or other conditions attributed to aging. Thus, depending on the optical properties of the composition of the present invention, it is possible to mask the aging of the biological surface, the dermatological degeneration and the defects of the biological surface, thereby improving the aesthetic and natural appearance of the skin. One embodiment of the present invention relates to a method of applying a nanocomposite pigment composition to a fork affected zone of the skin. Preferably, the composition is topically applied at least once a day, preferably twice a day, and the composition is maintained in the affected area of the skin, wherein the affected areas of the skin include, but are not limited to, the face, neck, legs and thighs, Scalp and body. The composition may be administered according to a particular regimen, e.g., daily administration for a period of weeks, weeks, two weeks, or more, or may be designed to be continued for each use. The cosmetic composition of the present invention can also be designed to be used after a period of time, and then applied when desired. The topical compositions preferably have cosmetic and/or aesthetic outer nanocomposite pigments which modify the skin, especially aged and/or inflamed skin. In another embodiment, the composition may have a total weight of 127,314.doc -17·200846026 based on the total weight of the composition, from about 5% to about 5%, preferably from about 5% to about 2%, more preferably. From about 10% to about 10% of the amount of nano-composite pigment material, #, for example, the natural and aesthetic appearance of the skin. change. The nanocomposite pigment composition can be used to improve the natural and aesthetic appearance of biological surfaces including skin, lips, hair and cingulates when applied, preferably in a topical application to a biological surface. In addition to carriers or vehicles, the compositions of the present invention may also include non-limiting examples of active ingredients that can be used to reduce, attenuate, or mask medical and/or cosmetic conditions associated with aging, inflammation, and degeneration of biological surfaces. . As used herein, such conditions generally include, but are not limited to, skin aging (age aging, hormonal aging and/or actinic aging), dermatitis, skin and hair fragility, hirsutism, rosacea, skin spots, sensitivity Skin, hyperpigmentation or hypopigmentation, thin skin, roughness, keratinization, skin atrophy, wrinkles, fine lines, hyperplasia, fibrosis, and any combination thereof. The active ingredients of the present invention can also be used to enhance the general health, vitality, condition and aesthetic appearance of the skin. According to the present invention, a composition comprising a nanocomposite pigment having a desired property can be used for topical application of a formulation, an antioxidant, an anti-inflammatory agent, a sunscreen, a cosmetic (including cosmetic products), and a skin condition for reducing aging (including wrinkles, Formulations for fine lines and sagging skin and the like. Also, according to the present invention, the other components in the composition can be formulated in various product forms. The enamel composition can be dried to produce sputum preparations such as creams, lotions, moisturizers, gels, toners, slurries, sprays, foams, powders and the like, especially for topical administration and administration. The present invention further provides a composition comprising a nanocomposite pigment, preferably 127314.doc -18 - 200846026 for topical administration or dry direction delivery without inducing significant irritation. The composition of the present invention j is sensitive to all skin types such as sensitivity, neutrality, dryness or oiliness, to the skin & mature skin. In particular embodiments, the compositions may be suitable for dry skin. The composition is applied to the skin for a period of time. • The time of the natural and aesthetic appearance of the skin is strong. The composition may be one daily: owed, twice or two: owed to the above surface _ on the biological surface, and the biological surfaces include (but Not limited to) skin, lips and hair. • The topical composition can be formulated in liposomes, which may contain other 'small additions d or substances and/or more specifically they may be modified to arrive or remain at a certain site after administration. . The compositions of the embodiments of the present invention produce an improvement in the aesthetic appearance of the skin by masking or venting to >, a condition as described above, or a combination thereof. It will be appreciated by practitioners that cosmetic treatments comprising nanocomposite pigments can be carried out, for example, by topical application of a cosmetic composition as described herein according to conventional techniques for administering such compositions. The topical cosmetic, dermo, or pharmaceutical composition is preferably administered once daily for a period of at least one week, but may include a period of about 2 weeks, 4 weeks, 8 weeks, 12 weeks, or more than 12 weeks. The cosmetic composition is preferably applied to the face and neck, but can also be applied to any area of the skin where aesthetic improvement is required, wherein the cosmetic composition remains in the affected area of the skin, and is preferably not removed or washed away from the skin. . Conventional and commonly practiced techniques encompass the application of creams, lotions, gels, serums, ointments, cosmetic products, sunscreen compositions or the like to the skin. The cosmetic composition is preferably a topical retention formulation' wherein spray is also contemplated as the form of application. Another embodiment of the present invention encompasses a composition comprising a cosmetic suitable for contact with living mammalian tissue comprising human tissue 127314.doc -19-200846026 or a synthetic equivalent thereof with little adverse physiological effects to the user. A study, dermatologically or medically acceptable nanocomposite pigment formulation. The compositions encompassed by the present invention may be provided in any cosmetically and/or dermatologically suitable form, preferably in the form of a lotion or cream, as well as in the form of an anhydrous or aqueous base, and in the form of a sprayable liquid. Other suitable cosmetic product forms of the compositions of the present invention include, but are not limited to, for example, lotions, creams, creams, lip glosses, lotions, foams' masks, serums, toners, ointments, mousses (m〇 Usse), patches, hair creams, solutions, sprays, wax-based sticks or wipes. In addition, the compositions encompassed by the present invention may include one or more compatible cosmetically acceptable adjuvants commonly used and understood by those skilled in the art, such as fragrances, emollients, moisturizers, preservatives, vitamins. , chelating agents, thickeners, perilla oil or perilla oil (W〇〇1/66〇67, ''Method of Treating a Skin c〇ndhi〇n", incorporated herein) and analogues thereof, and other plants Sex drugs such as aloe vera, chamomile and the like and as further described below. The nanocomposite pigment of the present invention may be contained in a cosmetically, dermatologically, physiologically and pharmaceutically acceptable vehicle, medium, diluent or carrier for reducing, improving or preventing biological surfaces. Skin symptoms associated with aging and inflammation. In embodiments including topical administration, the compositions of the present invention comprise a medium (media, diluent or carrier) which is associated with the skin of the skin comprising the skin, lips, hair and fingers. The compositions may be in the form of an aqueous phase, an oil phase, an alcohol or an aqueous/alcohol based solution, an ointment, a cream, a lotion, a gel, a water-carrying emulsion or a cream or gel, a microemulsion or a spray. 127314.doc -20- 200846026 View the water-in-oil emulsion, oil-in-water emulsion, water-oil-water triple emulsion form. The aqueous phase is a mixture of one or more water-soluble or water-dispersible ingredients which may be liquid, semi-solid or solid at room temperature (25. 〇, a suspension, dispersion or solution of the vehicle in water or Suspensions, dispersions or/valley/night forms in water or aqueous-alcoholic vehicles which may contain thickeners or guar coagulants. Those skilled in the art may choose appropriate knowledge based on knowledge of those skilled in the art. Cosmetic form, ingredients contained therein, and methods of making the same. In one embodiment, the composition can include an aqueous phase that can contain water or a mixture of water and at least one hydrophilic organic solvent, particularly an alcohol a linear or branched low carbon monohydric alcohol having 2 to 5 carbon atoms, such as 'ethanol or propanol; a polyhydric alcohol' such as propylene glycol, sorbitol, glycerin, diglycerin, ubiquinol or polyethylene glycol and A mixture thereof. The aqueous phase may comprise from about 0.5% by weight to about 99.99% by weight, based on the total weight of the composition. In another embodiment, when the composition of the present invention is in the form of an emulsion, the composition may optionally be based on The total weight of the composition is preferably from about 9% by weight to about 30% by weight and especially from about 1% by weight to about 20% by weight of the surfactant. In another embodiment of the invention, the composition is also A thickening polymer may be included, such as an amphiphilic polyurethane, a polyacrylic acid homopolymer or copolymer, a polyester or a smoke based resin. Other non-limiting polymers include the following: Or a copolymer; an aliphatic auxiliary having 1 to 18 carbon atoms; such as vinyl acetate; an acrylic acid having an alcohol having 1 to 18 carbon atoms and a methacrylate such as decyl acrylate, Ethyl acrylate, propylene 127314.doc • 21- 200846026 Butyl acrylate, 2-ethylhexyl acrylate, methacrylate methacrylate, ethyl methacrylate and butyl methacrylate; and mono- and diene unsaturated Hydrocarbons: including ethylene isobutylene, styrene and aliphatic dienes' including butadiene, isoprene and chloroprene. One embodiment of the invention is further related to the composition of the invention, which may also comprise Contains oil-soluble or oily liquids at room temperature (25^) An oil phase of a dispersed component and/or an oily or waxy substance (such as a wax, a semisolid, a jelly, and a mixture thereof) which is solid at room temperature. The oil phase may also contain an organic solvent. Suitable oily substances for liquids, commonly referred to as oils, including hydrocarbon-based oils of animal origin, such as perhydrosqualene; hydrocarbyl vegetable oils, liquid triglycerides of fatty acids such as 4 to 1 carbon atoms, for example, g. Acid or octanoic acid diglyceride, or oils such as sunflower oil, corn oil, dadan oil, grape seed oil, castor oil, avocado oil, caprylic acid/capric acid triglyceride, street shooter' by (i 〇j〇ba oil); linear or branched hydrocarbons of mineral or synthetic origin, such as liquid paraffin and its derivatives, petroleum jelly; synthetic esters and ethers, especially fatty alcohol esters, ie, for example, isopropyl myristate, 2-ethylhexyl palmitate, 2-octyldodecyl stearate, isostearyl isostearate; such as lactic acid isostearyl, octyl stearate , stearyl octyl octyl decyl ester, fatty alcohol heptanoate, octanoate and hydrazine Esters; polyterpene alcohol esters such as propylene glycol dicaprylate, neopentyl glycol diheptanoate, diethylene glycol diisodecanoate and isoamyl alcohol ester; fatty alcohols having 12 to 26 carbon atoms, such as Octyl dodecanol, butyl octanol, 2-hexyl decyl alcohol, 2 - eleven alkyl pentyl alcohol, oleyl alcohol; partially hydrocarbyl fluoride based oil and / or fluoropoly fluorene 1273l 4.doc -22- 200846026 oxygen By poly 7 Oxygen oils such as volatile or non-volatile linear or cyclic polybiguanide (氡s), which are liquid or semi-solid at room temperature, such as cyclomethicone and two A polychlorinated oxygen (including a phenyl group as the case may be, for example, a mixture of phenyl hydrazine and hydrazine). These oils are usually about a weight of the oil based on the weight of the oil phase. /α $ μ 里 is present in an amount of T J further / 0 to about 90% by weight, preferably about 1 weight 〇 / 〇 to about 80% by weight. The oil phase of the composition of the present invention may also comprise one or more cosmetically acceptable organic solvents. The solvents are from about 1% by weight to about 80% by weight, preferably about 10,000 parts by weight, based on the total weight of the composition. The amount is about 50% by weight and is optionally present in a lipophilic organic solvent, an amphiphilic organic solvent, and the like. a group of objects. Suitable solvents which can be used in the compositions of the invention include acetic acid vinegar, such as methyl acetate, ethyl acetate, butyl acetate, pentane acetate or 2-methoxyacetic acid acetate, isopropyl acetate; smoke, such as toluene , dimethyl, p-xylene, burned or calcined; contains at least 3 carbon atoms and their mixtures. This month's article, and the σ product can be further involved in any component commonly used in the field of cosmetics. Such ingredients include (iv) agents, aqueous thickeners (polysaccharide biopolymers, synthetic polymers) and fatty phase thickeners, fragrances, hydrophilic and lipophilic active agents, and mixtures thereof. The amounts of the various ingredients are generally used in the cosmetic field to achieve 苴宕曰宕曰、、、、庾庾庾庾庾庾 , , , , , , , , , ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( Within the scope of %, the nature and amount of such ingredients must be compatible with the manufacture of the compositions of the present invention. The compositions of the present invention may also comprise another particulate phase, which is typically based on the total weight of the composition. 〇"% by weight to about 3% by weight, preferably about 127314.doc -23-200846026 〇.5 wt% to about 20 wt%, and may include the pearlescent agent used in the cosmetic composition and/or Or a filler. Suitable pearlizing agents include mica coated with titanium dioxide or iron oxide. The filler is usually from about 1% by weight to about % by weight, based on the total weight of the composition, preferably from about 0.5% by weight to about 15% by weight. Suitable fillers include talc, silica dioxide, zinc stearate, mica, kaolin, nylon (especially orgasol) powder, polyethylene powder, Tefl〇, starch, boron nitride, Copolymer microspheres, such as Expanc El® (Nobel Industrie;

Sweden)、P〇lytrap⑧（Dow c〇rning，Inc ; Μί(11_，纽）及聚石夕氧樹脂微珠（T〇spearl®; GE Toshiba Silic_s; japan)。本發明組合物之油相可包含一或多種蠟、膠狀物或其混合物。該等蠟包括烴基蠟、氟基蠟及/或聚矽氧蠟且可為植物、礦物、動物及/或合成來源。蠟尤其具有大於25、較佳大於45 C之熔點。本發明之組合物可含有基於組合物之總重量計約〇· 1重量％至約2〇重量％之織。膠狀物通常為高分子量聚雙甲基矽氧烷（PDMS)、纖維素樹膠或多醣，且半固體物質通常為烴基化合物，諸如 (但不限於）羊毛脂及其衍生物，或者PDMS。本發明之組合物可含有以基於組合物之總重量計約0.1重量％至約20重量％、通常約〇·5重量％至約1〇重量％之膠狀物。更詳έ之，局部施用之組合物可呈用於皮膚、較佳面部 '頸部、手、足或身體之其他區域之保護性護理組合物形式。非限定性實例包括曰用乳霜或洗劑、夜用乳霜或洗劑、增濕劑、油膏、防曬霜、洗劑或油、軟膏、凝膠、體 127314.doc •24· 200846026 乳、化裝用品（粉底、古銅色化妝品）、人工曬黑組合物、脫毛劑、貼片、乳化劑或灌注或澆鑄成（例如）棒狀或盤狀之固體。奈米複合顏料在粉底產品中使用為理想的，因為其可達成高掩飾及模糊效應從而產生自然外觀之感覺。在另一實施例中，本發明之局部組合物亦可包括一或多種以下物質：皮膚渗透增強劑、潤膚劑、皮膚豐滿劑、光學漫射體、防曬劑、去死皮促進劑及抗氧化劑。關於該等及其他合適化妝品成分之細節可見於C〇smetic，Toiletry， • and Fragrance ASSOCiati〇n(CTFA)出版之 lnternationalSweden), P〇lytrap8 (Dow c〇rning, Inc; Μί(11_, New) and poly-stone resin beads (T〇spearl®; GE Toshiba Silic_s; japan). The oil phase of the composition of the invention may comprise One or more waxes, gums or mixtures thereof. The waxes include hydrocarbyl waxes, fluorine-based waxes and/or polyoxyxylene waxes and may be of plant, mineral, animal and/or synthetic origin. The waxes especially have greater than 25, more Preferably, the melting point is greater than 45 C. The composition of the present invention may contain from about 1% by weight to about 2% by weight based on the total weight of the composition. The gum is usually a high molecular weight polybismethyl decane. (PDMS), cellulosic gum or polysaccharide, and the semi-solid material is typically a hydrocarbyl compound such as, but not limited to, lanolin and its derivatives, or PDMS. The compositions of the present invention may contain, based on the total weight of the composition From about 0.1% by weight to about 20% by weight, usually from about 5% by weight to about 1% by weight, of the gel. More specifically, the topically applied composition can be applied to the skin, preferably the face 'neck Protective care composition for hands, feet or other areas of the body Non-limiting examples include creams or lotions, night creams or lotions, moisturizers, ointments, sunscreens, lotions or oils, ointments, gels, body 127314.doc •24· 200846026 Milk, cosmetic products (foundation, bronze cosmetics), artificial tanning compositions, depilatory agents, patches, emulsifiers or solids poured or cast into, for example, rods or discs. Nanocomposite pigments in foundation products Use is desirable because it achieves high masking and blurring effects to create a natural look. In another embodiment, the topical compositions of the present invention may also include one or more of the following: skin penetration enhancers, emollients Agents, skin fullness agents, optical diffusers, sunscreens, exfoliating agents and antioxidants. Details on these and other suitable cosmetic ingredients can be found in C〇smetic, Toiletry, • and Fragrance ASSOCiati〇n (CTFA) Published by lnternational

Cosmetic Ingredient Dictionary and Handbook，第 l〇版 (2004)(INCI)，第2177-2299頁，其整體以引用之方式併入本文中。潤膚劑提供增強皮膚光滑性、減少細紋及粗糙皺紋之外觀及增加水分之功能益處。非限定性實例包括肉豆蔻酸異丙酯、凡士林、羊毛脂酸異丙酯、聚矽氧（例如，甲聚石夕 _ 乳烧、一甲聚石夕氧烧）、油、礦物油、脂肪酸g旨或任何其混合物。潤膚劑較佳佔組合物之總重量之約〇·丨重量。/❻至約 50重量％。皮膚豐滿劑充當皮膚之膠原增強劑。合適且較佳之皮膚 ^ 豐滿劑之實例為軟脂醯基募肽。其他皮膚豐滿劑為膠原及/ 或葡糠胺聚糖（GAG)增強劑。皮膚豐滿劑較佳佔組合物之總重量之約0·1重量％至約20重量％。除奈米複合顏料外，涵蓋光學漫射體或柔焦物質，其改變皮膚表面光學性質，從而使得（例如）細紋或皺紋視覺上 127314.doc -25- 200846026 模糊及柔和。本發明中可使用之光學漫射體之實例包括 (但不限於)氮化爛、雲母、耐論、聚甲基丙稀酸甲醋 (糧μα)、、聚胺基曱酸8旨粉末、帛雲母、二氧切、聚石夕氧粉末、滑石、Teflon®、-夤务谷 ^ ^ 一乳化鈦、軋化鋅或任何其混 5物。光學漫射體較佳佔組合物之總重量之約“i重量。^ 至約2 0重量％。防曬劑保護皮膚以免受紫外線損害。在本發明之一說明性實施例中，防曬劑將藉由使用單一防曝劑或防嘴劑之电合提供㈣與UVB保護。本發明之組合物中可使用之防曝劑為埃文苯酮（aV〇benz_)、肉桂酸衍生物（諸如肉桂酸辛基甲氧基酯）、水揚酸辛酯、氧苯酮、非中孔性二氧化鈦、氧化辞或任何其混合物。防嘴劑可佔組合物之總重量之約1重里％至約30重量％。添加防曬劑可保護皮膚以免受紫外輻射影響。具有防曬劑之本發明之奈米複合顏料組合物對皮膚之美予外觀產生其他改善’包括至少—種下列情形：使曬傷最小化、使曬黑最小化及減少發紅。在本發明 < 一實施例中，、组合物亦可具有—或多種去死皮促進劑。本發明之組合物中可使用之去死皮促進劑之合適實例包括ex羥基酸（AHA);過氧苯甲醯；0羥基酸；酉同酸’諸如丙酮酸、2_側氧基丙酸、2_侧氧基丁酸及2_侧氧基戊酸；美國專利第5,847,〇〇3號及第5,834,513號（其揭示内容以引用之方式併人本文中）中的揭示之含氧酸；水揚酉文，尿素；或任何其混合物《一種較佳去死皮促進劑為 127314.doc -26- 200846026 乳酸或任何其混合物 3,6,9-三氧雜十一烷二酸、乙醇酸 (亦參見，INCI第2205頁）。當本發明之實施例包括去死皮促進劑時，該組合物具有以組合物之總重量計約0.1重量％至30重量％、較佳㈣量％至約！5重量％且更佳約!重量％至約1〇重量％之去死皮Cosmetic Ingredient Dictionary and Handbook, ed. (2004) (INCI), pp. 2177-2299, which is incorporated herein by reference in its entirety. Emollients provide functional benefits that enhance skin smoothness, reduce the appearance of fine lines and rough wrinkles, and increase moisture. Non-limiting examples include isopropyl myristate, petrolatum, isopropyl lanolate, polyoxyn (for example, methicillin _ milk burning, methicillin), oil, mineral oil, fatty acid g or any mixture thereof. The emollient preferably comprises about 〇·丨 of the total weight of the composition. /❻ to about 50% by weight. The skin plump agent acts as a collagen enhancer for the skin. An example of a suitable and preferred skin ^ fullness agent is a lipophylline-based peptide. Other skin plumping agents are collagen and/or glycosaminoglycan (GAG) enhancers. The skin plumping agent preferably comprises from about 0.1% by weight to about 20% by weight based on the total weight of the composition. In addition to nanocomposite pigments, it covers optical diffusers or softeners that alter the optical properties of the skin surface, making (for example) fine lines or wrinkles visually faint and soft. 127314.doc -25- 200846026 Examples of optical diffusers that can be used in the present invention include, but are not limited to, nitriding, mica, Nylon, polymethyl methacrylate (grain μα), polyamine phthalic acid 8 powder, Sericite, dioxin, poly-stone powder, talc, Teflon®, 夤谷 ^ ^ emulsified titanium, rolled zinc or any mixture thereof. The optical diffuser preferably comprises from about "i by weight to about 20% by weight of the total weight of the composition. The sunscreen protects the skin from UV damage. In an illustrative embodiment of the invention, the sunscreen will lend. Provided by the use of a single anti-amount or anti-mouthing agent to provide (iv) protection with UVB. The anti-exposure agents that can be used in the compositions of the present invention are esculine (aV〇benz_), cinnamic acid derivatives (such as cinnamic acid octyl). Methoxylate), octyl salicylate, oxybenzone, non-mesoporous titanium dioxide, oxidized or any mixture thereof. The mouth-stopping agent may comprise from about 1% by weight to about 30% by weight based on the total weight of the composition. The addition of a sunscreen protects the skin from UV radiation. The nanocomposite pigment composition of the present invention having a sunscreen provides other improvements in the appearance of the skin's appearance, including at least one of the following: minimizing sunburn and tanning Minimizing and reducing redness. In an embodiment of the present invention, the composition may also have one or more exfoliating accelerators. Suitable examples of exfoliating accelerators that can be used in the compositions of the present invention include Exoxyl Acid (AHA); benzoyl hydrazine; 0 hydroxy acid; hydrazine acid such as pyruvic acid, 2 _ oxoxypropionic acid, 2 _ oxoxybutyric acid and 2 valoxy valeric acid; Oxygenated acid disclosed in U.S. Patent No. 5,847, the disclosure of which is hereby incorporated by reference in its entirety in its entirety herein in The agent is 127314.doc -26- 200846026 lactic acid or any mixture thereof 3,6,9-trioxadecanedioic acid, glycolic acid (see also INCI page 2205). When embodiments of the invention include death In the case of a skin enhancer, the composition has from about 0.1% to about 30%, preferably from about 5% to about 5% by weight and more preferably from about 5% by weight to about 10,000% by weight based on the total weight of the composition. Exfoliating

抗氧化劑尤其用於自皮膚清除自由基以保護皮膚以免受環境攻擊者影響。本發明組合物中可使用之抗氧化劑之實 =包括具㈣㈣基官能基之化合物，諸如抗壞血酸及其何生物/g曰’ β_胡蘿蔔f ;兒茶素；薑黃；阿魏酸衍生物 (例如阿魏酸乙醋、阿魏酸鈉）；沒食子酸衍生物(例如，沒食丙醋k番祐紅素；還原酸；迷迭香酸；鞣酸；四風量黃；生育紛及其衍生4勿；尿酸或任何其混合物。其他合適的抗氧化劑為呈還原或非還原形式之具有一或多個硫醇B月t*基（SH)之^^氧化劑，諸如麵胱甘肽、硫辛酸、氣硫基乙酸及其他氫硫基化合物。抗氧化劑可為無機物，諸如亞硫酸氫鹽、偏亞硫酸氫鹽、亞硫酸鹽或其他含硫無機鹽及酸。本發明之組合物可具有組合物之總重量之較佳約 0.001重里％至約1〇重量％且更佳約〇〇1重量％至約5重量％之抗氧化劑。（亦參見，取以第2184頁）。在本發明之一實施例中，該組合物亦可具有一或多種下列化妝品及醫藥活性劑、賦形劑、成分或佐劑··麻醉劑·，抗生素’例如，紅黴素及四環素；水楊酸；抗過敏劑；抗真菌劑’防腐劑（antiSeptie);抗刺激劑；消炎劑；抗菌 127314.doc -27- 200846026 齊"止痛劑·’氧化氮合成酶抑制劑；驅昆蟲劑；自鞣劑；皮膚滲透增強劑；皮膚冷卻劑；養合劑；$色劑，包括可不經處理或經化學表面處理以改善潤濕性或—些其他性質之染料、色澱及顏料；緩和劑；潤膚劑；乳化劑；芳香劑；保濕劑；潤滑劑；護膚劑；增濕劑；pH值調節劑；防腐劑（P⑽—）；穩定劑；界面活性劑；增稠劑；成膜劑；增塑劑；黏度調節劑；維生素或任何其混合物。該等Antioxidants are especially useful for scavenging free radicals from the skin to protect the skin from environmental attackers. Antioxidants which can be used in the compositions of the invention include compounds having a (tetra) (tetra)-based functional group, such as ascorbic acid and its organism / g曰' beta-carrot f; catechin; turmeric; ferulic acid derivatives (eg Ferulic acid ethyl vinegar, sodium ferulate); gallic acid derivatives (for example, no vinegar k-bony erythropoietin; reducing acid; rosmarinic acid; citric acid; four air volume yellow; Derivatives 4; uric acid or any mixture thereof. Other suitable antioxidants are oxidizing agents having one or more thiol B* t groups (SH) in a reduced or non-reduced form, such as glutathione, sulfur Octanoic acid, thioacetic acid and other thiol compounds. The antioxidant may be an inorganic substance such as bisulfite, metabisulfite, sulfite or other sulfur-containing inorganic salt and acid. The composition of the present invention may have Preferably, the total weight of the composition is from about 0.001% by weight to about 1% by weight and more preferably from about 1% by weight to about 5% by weight of the antioxidant. (See also, page 2184.) In the present invention In one embodiment, the composition may also have one or more of the following Cosmetics and pharmaceutically active agents, excipients, ingredients or adjuvants · anesthetics ·, antibiotics 'for example, erythromycin and tetracycline; salicylic acid; anti-allergic agents; antifungal agents' antiseptants (antiSeptie); anti-irritants Anti-inflammatory agent; antibacterial 127314.doc -27- 200846026 Qi "analgesic·'Nitric oxide synthase inhibitor; insect repellent; self-tanning agent; skin penetration enhancer; skin coolant; nutrient; Including dyes, lakes and pigments which can be treated or chemically surface treated to improve wettability or some other properties; demulcents; emollients; emulsifiers; fragrances; moisturizers; lubricants; skin care agents; Wet agent; pH adjuster; preservative (P(10)-); stabilizer; surfactant; thickener; film former; plasticizer; viscosity modifier; vitamin or any mixture thereof.

各種物質之量為化妝品或醫藥領域中通常使用以達成其預定目的之量，例如其可構成組合物之總重量之約0.01%至 20% 〇調配於本發明之組合物中之活性劑之非限定性實例包括彼等對皺紋及/或細紋之治療具有作用之試劑，除所述活性劑外，諸如去角質劑’亦即，#有脫皮、去死皮或淨化性質之活性劑或可使皮膚之角質層軟化之活性劑。抗皺紋或抗細紋祕狀其他實例包括_岐類視色素。該等劑可（例如）以㈣於組合物之總重量約〇〇1重量％至5重量 %之量調配。醇酸、乳酸、蘋果酸、酒石桃酸、水揚酸及其烷基衍生 $正十一醯基水揚酸、5·正合適的羥基酸包括（例如）乙酸、檸檬酸、2-羥基烷酸、扁物，包括5-正辛醯基水揚酸、癸醯基水揚酸、5_正辛基水楊酸、5•正庚氧基水揚酸、4_ 正庚氧基水楊酸及2-羥基甲基苯f酸或其烷氧基衍生物，諸如2-羥基-3-甲氧基苯甲酸。以重量計約0,01重乳化劑通常以相對於組合物之總重量 127314.doc -28. 200846026 量％至3 0重量％及較佳以重量計約〇. 1重量％至3 〇重量％之量存在於本發明之組合物中。然而，並非所有組合物必將包括乳化劑。（參見，例如INCI第2276-2285頁）。 a適的增稠劑之非限疋性實例包括三仙膠（xanthan gum)、羥基丙基纖維素、羥基乙基纖維素、卡波姆 (carbomer)、***樹膠（gUm acaeia)、§epigel 3〇5(可獲自 Seppic Co·，France)及黏土（諸如矽酸鎂鋁）。（參見，例如 INCI第 2293-2299頁）。本發明之局部組合物可包括一或多種保濕劑且其實用性可由一或多種保濕劑增強，其諸如脲、吼p各咬酮叛酸、胺基酸、玻尿酸鈉、某些多元醇及其他具有吸濕性質之化合物。（參見INCI第2244頁）。本發明局部組合物對皮膚之一般活性及溫和性亦可藉由將pH值調節至約3·5至約7·5，最佳將pH值調節至約3·7至約5 ·6來增強。該中和較佳係用氫氧化銨、氫氧化鉀、氫氧化鈉、精胺酸或其他胺基酸及/或三乙醇胺中之一或多者來實現。例示性類視色素包括（不限於）維甲酸（例如，全反或13 _ 順）及其衍生物、視黃醇（維生素Α)及其酯，諸如視黃醇棕櫚酸醋、視黃醇乙酸酯及視黃醇丙酸酯及其鹽。本發明之奈米複合顏料可含於化妝品學或皮膚學上可接受之媒劑、介質、稀釋劑或載劑中。包含奈米複合顏料之局°卩組合物可根據此項技術已知之程序進一步調配以提供化妝πα組合物，諸如乳液、凝膠、乳霜、洗劑、面膜、調 1273l4.doc •29· 200846026 色劑、漿液、油、具有乳霜或凝膠之外觀之油包水乳液、水包油乳液、水·油-水三重乳液、微乳液、軟膏、糊劑、棒、餅、筆'噴霧劑及精油以及其他局部化妝品媒劑。亦涵蓋本發明之局部組合物可併入諸如脂質體及局部貼片、膠帶及喷霧之傳送系統中。另外，該等組合物可呈含有如上所述之離子及/或非離子脂質之泡狀分散液形式。根據此項技術中所使用之習知知識及技術調配適於該等組合物之劑量單位。實例下列實例描述本發明之特定態樣以說明本發明且為熟習此項技術者提供本發明方法之描述。該等實例不應理解為限制本發明，因為實例僅提供可用於本發明及其各種態樣之理解及實踐之特定方法學。實例1 在該實例中，使用奈米尺度煙霧狀二氧化矽調整不透明化妝品顏料之折射率以獲得最佳光漫射性質。該實例之奈米複合顏料包含核心（顏料）及外殼（奈米粒子），各自具有不同折射率。使用傳統Ti〇2顏料（約丨微米）作為核心物質，且使用奈米尺度（7 nm，初始粒度）高表面積（38〇 m2/g)煙霧狀二氧化矽作為外殼物質。該等物質提供具有極佳皮膚感覺之高效模糊性質。外殻與核心之間的折射率之差及其各自的體積分數確定光學性質。設計及選擇外殻奈米粒子及核心顏料可增加沿界面之光漫射。使用高表面積粒子增加沿界面之多次散 127314.d〇c _30· 200846026 射。圖1展不本發明之奈米複合顏料之光漫射性質之圖示描繪。光進入由具有低折射率之奈米粒子製成之奈米複合顏料外殼。The amount of each substance is an amount generally used in the cosmetic or pharmaceutical field to achieve its intended purpose, for example, it may constitute from about 0.01% to 20% of the total weight of the composition, and the active agent to be formulated in the composition of the present invention. Illustrative examples include those agents which have an effect on the treatment of wrinkles and/or fine lines, in addition to the active agents, such as exfoliating agents, ie, active agents which have peeling, exfoliating or decontaminating properties or An active agent that softens the stratum corneum of the skin. Other examples of anti-wrinkle or anti-fine lines include 岐-like retinoids. Such agents can be formulated, for example, in an amount of from about 1% to about 5% by weight based on the total weight of the composition. Alkyd, lactic acid, malic acid, tartaric acid, salicylic acid and its alkyl group derived from n-decylsalicylic acid, 5. Suitable hydroxy acids include, for example, acetic acid, citric acid, 2-hydroxyl Alkanoic acid, flat, including 5-n-octyl salicylic acid, decyl salicylic acid, 5_n-octyl salicylic acid, 5 • n-heptyloxy salicylic acid, 4_n-heptyloxysalicylic acid and 2-hydroxymethylbenzene f acid or an alkoxy derivative thereof such as 2-hydroxy-3-methoxybenzoic acid. The weight of the emulsifier of about 0,01 is usually 127,314.doc -28. 200846026% by weight to 30% by weight and preferably about 〇. 1% by weight to 3% by weight relative to the total weight of the composition. The amount is present in the compositions of the present invention. However, not all compositions will necessarily include an emulsifier. (See, for example, INCI, pages 2276-2285). Examples of non-limiting examples of suitable thickeners include xanthan gum, hydroxypropyl cellulose, hydroxyethyl cellulose, carbomer, gum arabic (gUm acaeia), §epigel 3 〇5 (available from Seppic Co., France) and clay (such as magnesium aluminum silicate). (See, for example, INCI page 2293-2299). The topical compositions of the present invention may include one or more humectants and their utility may be enhanced by one or more humectants such as urea, guanidine ketone, amino acids, sodium hyaluronate, certain polyols and others. A compound having hygroscopic properties. (See INCI page 2244). The general activity and mildness of the topical compositions of the present invention on the skin can also be enhanced by adjusting the pH to from about 3.5 to about 7.5, optimally adjusting the pH to from about 3.7 to about 5.6. . The neutralization is preferably carried out by one or more of ammonium hydroxide, potassium hydroxide, sodium hydroxide, arginine or other amino acids and/or triethanolamine. Exemplary retinoids include, without limitation, retinoic acid (eg, all-trans or 13 cis) and its derivatives, retinol (vitamin oxime) and its esters, such as retinyl palmitate, retinol B Acid esters and retinyl propionates and their salts. The nanocomposite pigments of the present invention may be contained in a cosmetically or dermatologically acceptable vehicle, medium, diluent or carrier. The composition comprising the nanocomposite pigment can be further formulated according to procedures known in the art to provide a cosmetic πα composition, such as an emulsion, a gel, a cream, a lotion, a mask, and a 1273l4.doc •29· 200846026 Toner, slurry, oil, water-in-oil emulsion with the appearance of cream or gel, oil-in-water emulsion, water-oil-water triple emulsion, microemulsion, ointment, paste, stick, cake, pen 'spray And essential oils and other topical cosmetic agents. It is also contemplated that the topical compositions of the present invention can be incorporated into delivery systems such as liposomes and topical patches, tapes and sprays. Alternatively, the compositions may be in the form of a blister dispersion containing ionic and/or nonionic lipids as described above. Dosage units suitable for the compositions are formulated according to conventional knowledge and techniques used in the art. EXAMPLES The following examples describe specific aspects of the invention to illustrate the invention and to provide a description of the method of the invention to those skilled in the art. The examples are not to be construed as limiting the invention, as the examples are only intended to provide a particular methodology of the invention and its various aspects. Example 1 In this example, the refractive index of an opaque cosmetic pigment was adjusted using nanoscale aerosolized cerium oxide to obtain optimum light diffusing properties. The nanocomposite pigment of this example comprises a core (pigment) and a shell (nanoparticle) each having a different refractive index. A conventional Ti 2 pigment (about 丨 micron) was used as a core material, and a nanometer scale (7 nm, initial particle size) high surface area (38 〇 m 2 /g) of smog-type cerium oxide was used as the outer shell material. These materials provide highly effective, fuzzy properties with excellent skin feel. The difference in refractive index between the outer shell and the core and their respective volume fractions determine the optical properties. Design and selection of shell nanoparticles and core pigments to increase light diffusion along the interface. The use of high surface area particles increases the number of scatters along the interface 127314.d〇c _30· 200846026. Figure 1 is a graphical representation of the light diffusing properties of the nanocomposite pigments of the present invention. Light enters the nanocomposite pigment shell made of nanoparticles having a low refractive index.

奈米複合顏料係使用美國專利第4,978,483號及美國專利第5,271，881號（其揭示内容以引用之方式併入本文中）中所述之M-Cap技術及如起始原料之混合時間、溫度及組成之控制參數藉由組合膠囊化方法之凝聚、造粒及喷霧乾燥原理來製備。奈米複合顏料之性質展示於下表丨中。奈米複合物可由已知使肉眼可見粒子塗佈有奈米粒子之任何方法製備。奈綠子可與聚合物結合在—起以在顏料形成塗層或可由靜電電荷使奈米粒子結合一起。表1 :奈米複合顏料之組成核心％ ('一氧化欽） 30 粒度The M-Cap technology and the mixing time and temperature of the starting materials, as described in U.S. Patent No. 4,978,483, and U.S. Patent No. 5,271,881, the disclosure of each of The control parameters of the composition are prepared by the principles of coagulation, granulation and spray drying of the combined encapsulation process. The properties of the nanocomposite pigments are shown in the following table. The nanocomposite can be prepared by any method known to coat macroscopic particles with nanoparticles. The nefer can be combined with the polymer to form a coating on the pigment or to bind the nanoparticles together by electrostatic charge. Table 1: Composition of Nanocomposite Pigments Core% ('Ig ing Chin) 30 granules

外殻％ (奈米尺度煙霧狀二氧化矽) 70 咸信模糊或柔焦效應之效能或遮蔽細紋及皺紋之能力隨漫射透射參數而變（"Quantifieati〇n 〇f此s〇ft f〇cusShell % (nanoscale smoked ruthenium dioxide) 70 The effectiveness of the ambiguous blur or soft focus effect or the ability to mask fine lines and wrinkles varies with diffuse transmission parameters ("Quantifieati〇n 〇f this s〇ft F〇cus

Effect”，C_etics & Toiletries ;第 lu 卷，1996年7月，第57頁）（其揭示内容以引用之方式併入本文中）。版他⑹ Color Research Laboratory之測角光譜光度計M〇dei GSp· 1B以透射核式使用。閃月无譖光度計 U /、处抓π八τ <丹反叩變之顏色。光源之角度在_65。$+以。@1 > τ/又你主+65〇變化且每1〇〇增量下收 127314.doc -31 · 200846026 集資料。透射模式中之光強（此處由L*值表示）隨角度而變化。強度隨光源遠離正常情況自小角度至大角度降低。將獲得半透明樣品之”鐘形曲線，，。咸信皮膚（半透明）上光漫射分布類似於傳統鐘形曲線之形狀。具有低中央峰（平坦）之鐘形曲線意謂表面下漫射程度高。猜測曲線越平坦（透射模式），表面下漫射越高，此歸因於類似於皮膚之光散射分布，給予自然外觀。當光必須穿行曲徑以到達細紋及皺紋時，廣角（+/_55。）下具有高強度之鐘形曲線為高效模糊之指示。因此，咸信模糊之效能隨廣角下透射光之強度而增加 (與正常情況相比）。Delrieu等人已開發藉由定量作為評估柔焦效能之參數之光束在膜上的擴散（側向漫射）進行之基於正向散射之類似方法（”In_Vitro Meth〇d f〇rEffect", C_etics &Toiletries; Vol., July 1996, p. 57) (the disclosure of which is incorporated herein by reference). (6) Color Research Laboratory Spectrophotometer M〇dei GSp·1B is used in transmission nucleus. Flash Moonlight luminometer U /, π 八 τ < Dan anti-deformation color. The angle of the light source is _65. $+ to. @1 > τ/ again Your main +65 〇 change and every 1 〇〇 increments 127314.doc -31 · 200846026 set data. The light intensity in the transmission mode (here represented by the L* value) varies with the angle. The intensity is away from the normal with the light source. The situation is reduced from a small angle to a large angle. A "bell curve" of the translucent sample will be obtained. The diffuse distribution of the skin (translucent) of the salty letter is similar to the shape of a traditional bell curve. A bell curve with a low central peak (flat) means a high degree of diffusion under the surface. The flatter the guess curve (transmission mode), the higher the diffusion under the surface, which is attributed to the light scattering distribution similar to the skin, giving a natural appearance. When the light must travel through the labyrinth to reach fine lines and wrinkles, the bell-shaped curve with high intensity at wide angle (+/_55.) is an indication of efficient blur. Therefore, the effectiveness of the fuzzy ambiguity increases with the intensity of the transmitted light at a wide angle (compared to normal conditions). Delrieu et al. have developed a similar method based on forward scattering by quantifying the diffusion (lateral diffusion) of a beam on a film as a parameter for evaluating soft focus performance ("In_Vitro Meth〇d f〇r

Quantification of Soft Focus Effect of Particulates"，PascalQuantification of Soft Focus Effect of Particulates", Pascal

Delrieu等人，NYSCC Scientific Meeting, New Y〇rk City， 12月8-9曰，2005)(其揭示内容以引用之方式併入本文中）。使用快速混合機與聚秒氧丙婦酸酯共合物（來自 Etsu之KP 5 50)(40%活性物（聚合物））在異十二燒中製備奈米複合顏料之實體摻合物。將溶液澆鑄於潔淨（光學透明）的玻璃板上且乾燥隔夜以形成乾燥膜，其中所得乾燥膜厚度為10微米。圖2展不聚碎氧丙婦酸I旨中2· 5(重量）％負载下羊焦物質之典型透射分布。奈米複合物（煙霧狀二氧化碎_Ti〇2)顏料 127314.doc -32- 200846026 與所使用之其他傳統上使用之軟焦點物質相比在廣角下展示較高L*值。圖3展示（+/_)55。（透射模式）丁平均L*值以及反射率資料之圖。煙霧狀二氧化矽-Ti〇2基奈米複合顏料與傳統上使用之柔焦物質（諸如，耐綸及聚乙烯）相比在可比反射率（不透明性）下展示較高L*值。圖4展示隨粒子負載而變之（+/_)55。下之平均L*值。由圖 4顯而易見，雖然柔焦效應之效能視粒子負載（重量μ而疋，但奈米複合顏料（煙霧狀二氧化矽_Ti〇2)在所有負载下證明有較高L*值。亦在彈性體凝膠基質中評估奈米複合顏料。圖5展示與其他粒子相比，彈性體凝膠基質中奈米複合顏料在（+/_) 55°下之平均l*值。在不同折射率基質中亦保持較高模糊。名專物貝之鬲模糊功效可歸於高表面積外殼以及增強界面處多次散射之大折射率差（核心與外殼）。另外，該等奈米複合顏料與耐綸相比具有極佳感覺。小二氧化矽粒子對皮膚產生滾珠效應（ball bearing effect)。雖然目W將耐綸視為工業中目前可用之最佳柔焦物質，但其缺乏良好的皮膚感覺。由便宜原料設計之奈米複合顏料證明有較高模糊功效以及極奢華之皮膚感覺。可藉由改變核心與外殼之折射率以及藉由改變核心與外殼之厚度達成多種光學性質，諸如模糊或不透明性。實例2 127314.doc -33- 200846026 表2列出本發明之兩種奈米複合顏料之性質。表2 :奈米複合顏料之組成核心％ (二氧化鈦）外殼％ (奈米尺度煙霧狀二氧化矽）粒度折射率 1 40 60 2-7微米 2.02 2 30 70 2-7微米 2.19 實例3 表3提供利用本發明之奈米複合顏料之三種原型粉底之配方。表3 :粉底原型之代表性配方奈米複合顏料(無機1102核心） 18.00 - 7 奈米複合顏料(無機氧化鐵核心） - 18 9 氯氧化絲 4 4 4 二曱聚石夕氧烧50cst 5 5 5 棕櫚酸異硬脂醯酯 4.00 4.00 4.00 乙烯基二甲聚矽氧烷/曱基倍半氧矽烷 2 2 2 二丙二醇 25 25 25 甘油 2 2 2 環曱聚矽氧烷/二曱聚矽氧烷共聚物 8 8 8 二甲聚矽氧烷共聚醇 2 2 2 環曱聚矽氧烷五聚物 10 10 10 環曱聚矽氧烷摻合物 1 1 1 水 19 19 21 (總計） 100.00 100.00 100.00 因此，本文所引用之所有專利、專利申請案、公開論文、摘要、書、參考手冊及摘要之内容其整體係以引用之 127314.doc -34- 200846026 方式併入本文以更徹底地描述本發明所屬之技術之現狀。除非另有㈣，否則本說明書及申請專利範目中所列舉之所有濃度均以重量。/。報導。 + 應理解’前述描述僅說明本發明。在不f離本發明之情況下，熟習此項技術者可設計各種替代及修改。因此，^ 發明意欲包括屬於附加申請專利範圍之範疇内之所有該替代、修改及變化。 ^ 【圖式簡單說明】圖圖1展示光與本發明之奈米複合顏料之相互作用之示音圖2展示4種奈米複合顏料之透射分布。圖3展示聚石夕氧㈣酸酉旨中柔焦、物質之（+/-)55。透射之平均L*。刀布圖4展示隨聚矽氧丙烯酸輯中粒子負载而變下之平均L·*。 ) 圖5展示彈性體-粒子摻合物之平均L*值。 1273l4.doc 35·Delrieu et al., NYSCC Scientific Meeting, New Y〇rk City, Dec. 8-9, 2005) (the disclosure of which is incorporated herein by reference). A solid blend of nanocomposite pigments was prepared in a dodecacin using a fast mixer in combination with a polysecoxyprostate complex (KP 5 50 from Etsu) (40% active (polymer)). The solution was cast on a clean (optically clear) glass plate and dried overnight to form a dried film having a dried film thickness of 10 μm. Fig. 2 shows the typical transmission distribution of the coke material under the load of 2.5% by weight in the non-aggregated acetoacetate. Nanocomposite (Smoke Dioxide _Ti〇2) Pigment 127314.doc -32- 200846026 A higher L* value is exhibited at wide angle compared to other conventionally used soft focus materials. Figure 3 shows (+/_) 55. (Transmission mode) A graph of the average L* value and reflectance data. The aerosol-like cerium oxide-Ti〇2 ketone composite pigment exhibits a higher L* value at comparable reflectance (opacity) than conventionally used soft-focus materials such as nylon and polyethylene. Figure 4 shows (+/_) 55 as a function of particle loading. The average L* value below. As is apparent from Fig. 4, although the effect of the soft focus effect is on the particle load (weight μ and 疋, the nanocomposite pigment (smoke cerium dioxide _Ti〇2) has a higher L* value under all loads. The nanocomposite pigment was evaluated in an elastomeric gel matrix. Figure 5 shows the average l* value of the nanocomposite pigment in the elastomeric gel matrix at (+/_) 55° compared to the other particles. The matrix also maintains a high degree of ambiguity. The ambiguous effect of the name 贝贝可可 can be attributed to the high surface area outer shell and the large refractive index difference (core and outer shell) of multiple scattering at the enhanced interface. In addition, these nano composite pigments and nylon Compared to the excellent feeling, small cerium oxide particles have a ball bearing effect on the skin. Although nylon is regarded as the best soft-focusing material currently available in the industry, it lacks a good skin feel. Nano-composite pigments designed from inexpensive raw materials have demonstrated high blurring and extremely luxurious skin feel. A variety of optical properties can be achieved by changing the refractive indices of the core and the shell and by varying the thickness of the core and the shell. Qualitative, such as ambiguity or opacity. Example 2 127314.doc -33- 200846026 Table 2 lists the properties of the two nanocomposite pigments of the present invention. Table 2: Composition core of nanocomposite pigment % (titanium dioxide) Nanoscale aerosolized cerium oxide) Particle size refractive index 1 40 60 2-7 micron 2.02 2 30 70 2-7 micron 2.19 Example 3 Table 3 provides formulations of three prototype foundations utilizing the nanocomposite pigments of the present invention. : representative formula of foundation prototype nano-composite pigment (inorganic 1102 core) 18.00 - 7 nano-composite pigment (inorganic iron oxide core) - 18 9 chlorine-oxidized wire 4 4 4 diterpene poly-stone oxygen 50cst 5 5 5 palm Isostearyl oxime ester 4.00 4.00 4.00 Vinyl dimethyl polyoxy siloxane / decyl sesquioxanes 2 2 2 Dipropylene glycol 25 25 25 Glycerol 2 2 2 Cyclodecyl polyoxy siloxane / Dioxane polyoxyalkylene copolymerization 8 8 8 Dimethoxane copolyol 2 2 2 Cyclodecyl polyoxyalkylene pentamer 10 10 10 Cyclodecyl polyoxy oxyalkylene blend 1 1 1 Water 19 19 21 (total) 100.00 100.00 100.00 , all patents, patent applications, and public opinions cited in this article The contents of the abstract, the book, the reference manual, and the abstract are hereby incorporated by reference in their entirety to the extent of the entire disclosure of the disclosure of the disclosure of the disclosure of All concentrations recited in the patent application are reported as weights. /. It is to be understood that the foregoing description is only illustrative of the invention. Various alternatives and modifications can be devised by those skilled in the art without departing from the invention. Therefore, the invention is intended to cover all such alternatives, modifications and variations in the scope of the appended claims. ^ [Simple Description of the Drawings] Figure 1 shows the sound of the interaction of light with the nano-composite pigment of the present invention. Figure 2 shows the transmission distribution of four kinds of nano-composite pigments. Figure 3 shows the soft focus of the polysulfate (tetra) acid, (+/-) 55. The average L* of transmission. Knife cloth Figure 4 shows the average L·* as a function of particle loading in the polyoxy acrylate series. Figure 5 shows the average L* value of the elastomer-particle blend. 1273l4.doc 35·

Claims

200846026十、申請專利範圍： I · 一種化妝品或醫藥組合物，其包含·· (a) 奈米複合顏料，其包含·· (1) 核心，及 (2) 外喊’其包含奈米粒子及黏合劑；其中該核心具有大於該等奈米粒子之折射率的折射率；及 (b) 化妝品學上或醫藥學上可接受之媒劑。如請求項1之組合物，其中該等奈米粒子為煙霧狀二氧化矽且其中該核心為二氧化鈦。如请求項1之組合物，其中該核心具有約16至3·4之折射率且其中該等奈米粒子具有約14至2·5之折射率。如π求項1之組合物，其中該核心與奈米粒子之折射率之差為約0.2至約2。如睛求項1之組合物，其中該奈米複合顏料具有折射率’其中該折射率為約2.02至約2.19。如明求項1之組合物，其中該核心為約〇·3微米至約丨〇微米。如明求項1之組合物，其中該核心為約〇·5微米至2微米。 8·如明求項7之組合物，其中該等奈米粒子之大小係在約7 nm至約3〇〇 nm範圍内。 9·如明求項7之組合物，其中該等奈米粒子之平均粒度為約7_至約3〇〇nm。 1〇·如靖求項7之組合物，其中該黏合劑係至少半透明。 II ·如’求項1之組合物，其中該奈米粒子外殻與該核心顏 2. 3. 4. 5. 6. 127314.doc 200846026 料之重量比係在約5%至約95%範圍内。 12·如請求項丨之組合物，其中構成該奈米複合顏料之外殼之該等奈米粒子的總表面積為約7〇 m2/g至約4〇〇 m2/g。 13·如凊求項10之組合物，其中該奈米複合顏料係以當局部施用於皮膚時可改善該皮膚之外觀之有效量存在。 14· 一種奈米複合顏料，其包含内核及外殼，其中該核心包含有機或無機顏料且其中該外殻包含奈米粒子及黏合劑，該核心具有一折射率且構成該外殼之該等奈米粒子具有一折射率，其中該核心之折射率大於該等奈米粒子之折射率。 15. 種奈米複合顏料，其包含内核顏料及奈米粒子與黏合之外设，該核心具有一折射率且該等奈米粒子具有一 =射率，其中該核心之折射率大於該等奈米粒子之折射率，且其中構成該奈米複合顏料之外殼之該等奈米粒子的總表面積為約2〇 m2/g至約7〇〇 m2/g。 16.200846026 X. Patent application scope: I · A cosmetic or pharmaceutical composition comprising: (a) a nano-composite pigment comprising: (1) a core, and (2) a shouting 'which contains nanoparticles and a binder; wherein the core has a refractive index greater than a refractive index of the nanoparticles; and (b) a cosmetically or pharmaceutically acceptable vehicle. The composition of claim 1 wherein the nanoparticles are fumed cerium oxide and wherein the core is titanium dioxide. The composition of claim 1 wherein the core has a refractive index of from about 16 to about 3.4 and wherein the nanoparticles have a refractive index of from about 14 to about 2.5. A composition of claim 1, wherein the difference between the refractive index of the core and the nanoparticles is from about 0.2 to about 2. The composition of claim 1, wherein the nanocomposite pigment has a refractive index < wherein the refractive index is from about 2.02 to about 2.19. The composition of claim 1, wherein the core is from about 3 micrometers to about ten micrometers. The composition of claim 1, wherein the core is from about 5 microns to about 2 microns. 8. The composition of claim 7, wherein the nanoparticles are sized from about 7 nm to about 3 Å. 9. The composition of claim 7, wherein the nanoparticles have an average particle size of from about 7 to about 3 Å. The composition of claim 7, wherein the binder is at least translucent. II. The composition of claim 1, wherein the nanoparticle shell and the core pigment 2. 3. 4. 5. 6. 127314.doc 200846026 The weight ratio of the material is in the range of about 5% to about 95%. Inside. 12. The composition of claim 1, wherein the nanoparticle constituting the outer shell of the nanocomposite pigment has a total surface area of from about 7 〇 m2/g to about 4 〇〇 m2/g. 13. The composition of claim 10, wherein the nanocomposite pigment is present in an amount effective to improve the appearance of the skin when applied topically to the skin. A nanocomposite pigment comprising a core and an outer shell, wherein the core comprises an organic or inorganic pigment and wherein the outer shell comprises nano particles and a binder, the core having a refractive index and constituting the nano shell of the outer shell The particles have a refractive index wherein the core has a refractive index greater than the refractive indices of the nanoparticles. 15. A nanocomposite pigment comprising an inner core pigment and a nanoparticle and a binder, the core having a refractive index and the nanoparticle having a refractive index, wherein the core has a refractive index greater than the nanosphere The refractive index of the rice particles, and wherein the nanoparticles constituting the outer shell of the nanocomposite pigment have a total surface area of from about 2 μm 2 /g to about 7 μm 2 /g. 16.

如明，項15之奈米複合顏料，其中構成該奈米複合顏料之外喊之該等奈米粒子的總表面積為約7〇 m2/g至約4⑼ m2/g 〇 17·如明求項!之組合物，其中該黏合劑係選自由以下各物組成之群··幾甲基纖維素、聚乙烯醇、聚醯胺、聚氯乙烯、聚胺基甲酸酯、聚甲基丙烯酸甲酯、堪、三胺、環氧樹脂及其混合物。月 18·如明求項!之組合物，其中該黏合劑為三聚氰 127314.doc 200846026 19·如請求項2之組合物，其中該黏合劑為三聚氰胺或環氧樹脂。 2〇·如請求項17之組合物，其中該核心具有約ι·4至約3乃之折射率。月长項17之組合物’其中該等奈米粒子具有約1 · 4至約 1 · 6之折射率。月求項17之組合物’其中該核心具有約1 · §至2 · $之折射率且其中該等奈米粒子具有約1.4至1.6之折射率。 23·如明求項17之組合物，其中該核心之折射率與該等奈米粒子之折射率之差為約0.2至約2。 24. 如請求項17之組合物，其中該奈米複合顏料具有折射率’其中該折射率為約2.02至約2.19。 25. 如請求項17之組合物，其中該核心為約0.3微米至約2微 26. 如明求項17之組合物，其中該等奈米粒子之大小係在約 7 nm至約3〇〇 nm範圍内。 27·如印求項17之組合物，其中該等奈米粒子之平均粒度為約7 nm至約300 nm。 28·如明求項17之組合物，其中該核心為約微米且其中該等奈米粒子之平均粒度為約7 nm。 29·如請求項17之組合物，其中該奈米粒子外殼與該核心顏料之重量比係在約5%至約95%範圍内。 3〇·如請求項17之組合物，其中構成該奈米複合顏料之外殼之該等奈米粒子的總表面積為約7〇 m2/g至約4〇〇 m2/g。 127314.doc 200846026 3!.如凊未項R組合物，其中該等奈米粒子為煙霧狀二氧化石夕，其中該核心為二氧化鈦或氧化鐵，且其中該黏合劑為二聚氰胺或環氧樹脂’且其中該奈米複合顏料具有約2.02至約2.19之折射率。 32. t請求項18之組合物，其中該㈣複合顏料係以當局部鈿用於皮膚時可改善該皮膚之外觀之有效量存在。 33. —種化妝品或醫藥組合物，其包含： (a) 奈米複合顏料，其包含·· (1) 二氧化鈦内核，及 (2) 煙霧狀二氧化石夕奈米粒子與黏合劑之外殼；及 (b) 化妝M學上或醫藥學上可接受之媒劑。 34·如請求項33之組合物，其中該黏合劑係選自由以下各物成之群缓甲基纖維素、聚乙烯醇、聚醯胺、聚氯乙烯、聚胺基甲酸酯、聚甲基丙烯酸甲酯、蠟、三聚氰胺及環氧樹脂。 :求項33之組合物，其中該黏合劑為三聚氰胺或環氧树脂。 36.如請求項33之組合物，其中該黏合劑為至少光學半透明之黏合劑。 37· 一種化妝品或醫藥組合物，其包含： (a)奈米複合顏料，其包含·· )氧化鈦内核，其中該核心為約0.5至10微米，及 ⑺煙霧狀二氧切奈米粒子與黏合劑之外殼，該等车半# π ' τ ’、、枝子之平均粒度為約111111至2〇〇11111;及 127314.doc 200846026 (b)化妝品學上或醫藥學上可接受之媒劑其中該黏合劑為光學半透明之黏其中該黏合劑為三聚氰胺或環氧 38·如請求項37之組合物合劑。 39·如請求項37之組合物樹脂。 40.ΓΓ項38之組合物，其中該奈米複合顏料係以當乃部把用於皮膚時可改善該皮膚之外觀之有效量存在。 41· 一種形成奈米複合顏料之方法，其包含·· ⑴形成奈米粒子、顏料、黏合劑及溶劑之混合物； (2) 向該混合物中添加水； ’ (3) 自該混合物中移除溶劑；及 (4) 自該混合物中移除水。 42.::求項41之方法’其中該顏料為二氧化奈米粒子為煙霧狀二氧化矽。 Μ專如明求項41之方法，其巾該黏合劑洛之雜•鉍田* , 曰田U下各物組成之群·竣甲基纖維素、聚乙稀醇、聚酿胺烯、聚胺基甲酸酯、聚甲基丙烯酸甲酯、氧樹脂及其混合物。 A 、環 44. 如請求項41之方法，其中該脂》 d為—聚虱胺或環氧樹 45. 如請求項41之方法，其中該顏料係選自由之群：二氧化鈦、氧化鍅、氡化鈽、氧化鋅組成氧化鉻、鐵藍、群青、鋇色澱、錯色；化：、澱及碳黑。巧色表、链色 127314.doc 200846026 46. ^明求項41之方法，其中該等奈米粒子係選自由以下各組成之群：煙霧狀二氧化石夕、氧化銘、氧化鋅、二氧錘、聚(甲基丙烯酸甲醋)、耐論、聚乙浠、^乙烯、聚四氣乙浠、纖維素及其混合物。 4 7 ·如請求項4 1夕ne 4 ^ , 烴、芳柄法’，、中該溶劑係選自由烷烴、環烷二矢、災及其混合物組成之群。4 8 ·如清求項4〗之方法，苴 ⑭·如請求項41之方法，：1:劑為環己烧。 ^. ，、中Μ顏料為二氧化鈦，其中該等不未粒子為煙霧狀二氧化石夕，其中該羝人、中該浴劑為環己烷，且舞合劑為三聚氰胺或環氧樹脂。 50·如明求項41之方法，其中帅黏合劑。 Μ為至少光學半透明之 ⑩ 127314.docThe nanocomposite pigment of item 15, wherein the total surface area of the nano particles constituting the nano composite pigment is about 7 〇 m 2 /g to about 4 (9) m 2 /g 〇 17 · The composition, wherein the binder is selected from the group consisting of: methine cellulose, polyvinyl alcohol, polyamine, polyvinyl chloride, polyurethane, polymethyl methacrylate Esters, cans, triamines, epoxies and mixtures thereof. The composition of claim 18, wherein the binder is melamine 127314.doc 200846026 19. The composition of claim 2, wherein the binder is melamine or an epoxy resin. The composition of claim 17, wherein the core has a refractive index of from about 1⁄4 to about 3. The composition of the term of the term 17 wherein the nanoparticles have a refractive index of from about 1/4 to about 1.6. The composition of claim 17 wherein the core has a refractive index of from about 1 § to 2 · $ and wherein the nanoparticles have a refractive index of from about 1.4 to 1.6. The composition of claim 17, wherein the difference between the refractive index of the core and the refractive index of the nanoparticles is from about 0.2 to about 2. 24. The composition of claim 17, wherein the nanocomposite pigment has a refractive index' wherein the refractive index is from about 2.02 to about 2.19. 25. The composition of claim 17, wherein the core is from about 0.3 micron to about 2 micro. 26. The composition of claim 17, wherein the nanoparticles are between about 7 nm and about 3 Å in size. Within the nm range. The composition of claim 17, wherein the nanoparticles have an average particle size of from about 7 nm to about 300 nm. 28. The composition of claim 17, wherein the core is about microns and wherein the average particle size of the nanoparticles is about 7 nm. The composition of claim 17, wherein the weight ratio of the nanoparticle shell to the core pigment is in the range of from about 5% to about 95%. The composition of claim 17, wherein the nanoparticle constituting the outer shell of the nanocomposite pigment has a total surface area of from about 7 〇 m 2 /g to about 4 〇〇 m 2 /g. 127314.doc 200846026 3!. The non-R composition, wherein the nano particles are fumed silica dioxide, wherein the core is titanium dioxide or iron oxide, and wherein the binder is melamine or ring The oxy-resin' and wherein the nano-composite pigment has a refractive index of from about 2.02 to about 2.19. 32. The composition of claim 18, wherein the (iv) composite pigment is present in an amount effective to improve the appearance of the skin when the topical mash is applied to the skin. 33. A cosmetic or pharmaceutical composition comprising: (a) a nanocomposite pigment comprising: (1) a titanium dioxide core, and (2) an outer shell of aerosolized cerium oxide nanoparticles and a binder; And (b) a cosmetically or pharmaceutically acceptable vehicle. 34. The composition of claim 33, wherein the binder is selected from the group consisting of slow methylcellulose, polyvinyl alcohol, polyamine, polyvinyl chloride, polyurethane, polymethyl Methyl acrylate, wax, melamine and epoxy resin. The composition of claim 33, wherein the binder is melamine or an epoxy resin. The composition of claim 33, wherein the binder is at least an optically translucent binder. 37. A cosmetic or pharmaceutical composition comprising: (a) a nanocomposite pigment comprising: a titanium oxide core, wherein the core is between about 0.5 and 10 microns, and (7) smog-type dioxycene nanoparticles and The outer shell of the adhesive, the semi-# π ' τ ', the average particle size of the branches is about 111111 to 2〇〇11111; and 127314.doc 200846026 (b) cosmetically or pharmaceutically acceptable agents. The adhesive is an optically translucent adhesive wherein the adhesive is melamine or epoxy 38. The composition of the composition of claim 37. 39. The composition of claim 37, a resin. 40. The composition of claim 38, wherein the nanocomposite pigment is present in an amount effective to improve the appearance of the skin when applied to the skin. 41. A method of forming a nanocomposite pigment, comprising: (1) forming a mixture of nanoparticles, a pigment, a binder, and a solvent; (2) adding water to the mixture; '(3) removing from the mixture a solvent; and (4) removing water from the mixture. 42.: The method of claim 41 wherein the pigment is a carbon dioxide nanoparticle which is fumed ceria. ΜSpecially, according to the method of Item 41, the towel is made of Luozhizao·铋田*, the group of various substances under the 曰田U, 竣methylcellulose, polyethylene glycol, polyarene, poly Carbamates, polymethyl methacrylates, oxygen resins, and mixtures thereof. A method of claim 41, wherein the lipid d is a polyamine or an epoxy tree. The method of claim 41, wherein the pigment is selected from the group consisting of titanium dioxide, cerium oxide, cerium Huatan, zinc oxide constitutes chromium oxide, iron blue, ultramarine blue, strontium lake, discoloration; chemical:, lake and carbon black. The method of claim 41, wherein the nanoparticles are selected from the group consisting of: smog-like dioxide, oxidized, zinc oxide, dioxane Hammer, poly (methyl methacrylate), Nai, Polyethylene, Ethylene, Polytetraethylene, cellulose and mixtures thereof. 4 7 · The claim 4 1 ne ne 4 ^ , a hydrocarbon, an aromatic handle method, wherein the solvent is selected from the group consisting of an alkane, a cycloalkane, a disaster, and a mixture thereof. 4 8 · The method of claim 4, 苴 14 · The method of claim 41, 1: 1: The agent is cyclohexane. The middle pigment is titanium dioxide, wherein the non-unparticles are fumed silica dioxide, wherein the bath, the bath is cyclohexane, and the dance agent is melamine or epoxy resin. 50. The method of claim 41, wherein the binder is handsome. Μ is at least optically translucent 10 127314.doc