200841886 八、本案若有化學式時，請揭示纖顯示發明特徵的化學式: 2N02" + H+- 2NO + H2〇 九、發明說明： 【發明所屬之技術領域】 ‘本發明涉及一種生髮用品和保健品，特別涉及一種以一氧化氮爲基礎的健髮、防 脫髮、生髮和美容的生髮配製品。 [先前技術] 隨著人類生活水準的提高，人們對自己的外在形象越來越重視。但由於現在人們的 • 工作和生活節奏加快，腦力思考負荷的加重以及其他原因，致使脫髮的現象越來越 普遍’而脫髮妨礙了美觀，令不少人感到痛苦，甚至嚴重影響到了一些人的正常生 活。 脫髮基本上可以分爲暫時性脫髮和永久性脫髮兩種。暫時性脫髮大多由於發高燒、 營養不良、或是某些帶炎症的皮膚^、慢性消耗性疾病，以及內分泌失調各種原因 使毛囊血液供應減少’或者局部神經調節功能發生障礙，以致毛囊暫時性營養不良 而產生脫髮現象。而永久性脫髮亦可稱爲男性禿頭，較爲常見，是由於毛囊長時間 受損而造成的。 脫髮的根本原因是毛囊受損，即毛囊在不同程度上的萎縮造成了脫髮，其中最爲常 見的脂溢性脫髮正是因爲頭蟎分解皮脂將毛囊堵住，無法向毛髮輸送營養所至。 根據硏究表明：正常人頭皮血流量約9倍於身體其他部位，但脫髮禿頭的患者，頭 皮血流量與正常人對照相比爲13. 7 : 53. 7，差別極爲顯著。 而如今市場上生髮產品，大多只是通過刺激毛細血管，增加毛囊供氧量，供毛髮生 • 長，但毛囊本身機制並沒有得到很好的改善，因此容易產生賴藥性。 自從1987年發現哺'乳動物血管內皮細胞能合成內源性一氧化氮以來，一氧化氮這 個簡單的雙原子分子自由基便開始向世人展示其無窮的魅力，被美國《Science》 雜誌評爲1992年的“明星分子” （Molecule of the Year)。時隔5年，美國科 學家Ignarro，Murad和Fuchgott等由於對“一氧化氮作爲心血管系統的信號分 子”的傑出工作而榮膺1998年度的諾貝爾醫學獎。他們的硏究揭示了氣體分子在 生物體中的信號傳導作用，從而激起了全球醫學界、生物學界以及化學界對一氧化 氮的硏究熱潮。200841886 VIII. If there is a chemical formula in this case, please disclose the chemical formula showing the characteristics of the invention: 2N02" + H+- 2NO + H2〇9, invention description: [Technical field of invention] The present invention relates to a hair growth product and a health care product, In particular, it relates to a hair growth preparation based on nitric oxide for hair growth, hair loss prevention, hair growth and beauty. [Prior Art] With the improvement of human living standards, people pay more and more attention to their external image. However, because people's work and life rhythm is accelerating, brain power is thinking about the increase of load and other reasons, the phenomenon of hair loss is becoming more and more common. And hair loss hinders the appearance, which makes many people feel painful and even seriously affects some people. Normal life. Hair loss can be basically divided into temporary hair loss and permanent hair loss. Temporary hair loss is mostly caused by high fever, malnutrition, or some skin with inflammation, chronic wasting disease, and endocrine disorders, which reduce the blood supply of hair follicles or local neuromodulation disorders, resulting in temporary nutrition of hair follicles. Poor and undiscovered. Permanent hair loss can also be called male baldness, which is more common because of long-term damage to hair follicles. The root cause of hair loss is hair follicle damage, that is, hair follicle atrophy caused by hair loss to varying degrees. The most common seborrheic alopecia is caused by the decomposition of sebum by the head lice to block the hair follicle and the inability to deliver nutrients to the hair. According to the study, the normal human scalp blood flow is about 9 times that of other parts of the body, but in patients with alopecia, the scalp blood flow is 13.7: 53.7, and the difference is extremely significant. However, most of the products produced on the market today only stimulate the capillaries, increase the oxygen supply of the hair follicles, and the hair supply is long. However, the mechanism of the hair follicle itself has not been well improved, so it is easy to produce drugs. Since 1987, when it was discovered that vascular endothelial cells can synthesize endogenous nitric oxide, nitric oxide, a simple diatomic molecular free radical, has begun to show its infinite charm to the world, which was rated by the US magazine Science. 1992 "Molecule of the Year". After a lapse of five years, American scientists Ignarro, Murad, and Fuchgott won the 1998 Nobel Prize in Medicine for their outstanding work on "Nitric Oxide as a Signaling Signal for the Cardiovascular System." Their research reveals the signal transduction of gas molecules in living organisms, which has aroused the enthusiasm for nitric oxide in the medical, biological and chemical worlds.
一氧化氮是一種血管舒張成份，可讓讓血管放鬆，進而加大血液流量，促進血液循 環，即有增力Π局部的血液循環和氧氣供給的功能。一氧化氮是一種非常小的親脂分 子，通過旁分泌作用經生物膜屏障迅速擴散，到達鄰近不同的靶細胞內，並與細胞 中的鳥苷酸環化酶的亞鐵血紅蛋白部分相連，引起酶啓動，使三磷酸鳥苷轉化爲環 磷酸鳥苷(cGMP)的轉化率增加50 — 200倍，導致細胞內cGMP增加。cGMP進而啓 動GMP依賴性蛋白激酶或直接作用於細胞膜上的鈣離子通道，引起鈣離子外流或力口 速細胞內游離鈣的結合，從而使平滑肌細胞舒張和血管擴張，在此過程中，cGMP 4 200841886 起著第二信使的作用。同時，GMP也可抑制血小板聚集以及血/Jx®在血管內皮表面 的粘附。由於一氧化氮合成參與了幾種病原的非特異性防禦。巨噬細胞等在啓動時 或在某些病理條件下可大量合成釋放一氧化氮，發生細胞毒作用，抑制靶細胞線粒 體中TCA、電子傳遞和細胞DNA合成等途徑對細菌、真菌和腫瘤細胞產生殺傷作用， 促進組織急性炎症反應，參與組織損傷和傷口癒合，從而引起組織損傷和（或）細 胞壞死，殺傷細菌、病毒、寄生蟲和腫瘤細胞等。 一氧化氮是一種血管舒張成份，可讓讓血管放鬆，進而加大血液流量，促進血液循 環，SP有增加局部的血液循環和氧氣供給的功能，同時，因爲一氧化氮對細菌、真 菌、寄生蟲、瘤細胞有殺傷作用。而作爲脫髮元兇的頭蟎是一種寄生在頭皮上的微 小動物，它們寄生在人類的毛囊裏，以皮脂爲食物，並且分泌解脂酵素，侵飩皮脂 腺，阻塞毛囊。最常見的是糠秕孢子菌，真菌的一種，引發JI旨溢性脫髮的原因之一。 目前，尙未見基於一氧化氮的生髮用品的報導。 【發明內容】 本發明的目的是提供一種通過一氧化氮促進腦部毛細血管的舒張，來增加毛囊的 — 供血供氧量，同時對毛囊進行清理、修復，徹底改善毛囊自身和周圍環境，增強頭 部毛髮整體生長狀況，並且不會產生賴藥性的健髮、防脫髮、生髮和美容的生髮配 製品。 、 本發明是以如下技術方案實現的： 本發明是基於一氧化氮能夠改善毛囊品質的保健用品和特殊類生髮用品，由氮 劑和酸劑構成。 其中：氮劑以亞硝酸鹽或者含有亞硝酸鹽的植物萃取液爲原料；酸劑以有機酸或無 機酸爲原料。當氮劑和酸劑結合時，便可局部可控制的釋放有效成分一一氧化氮。 本發明的雙劑型生發配製品及其製造流程： 本發明的氮劑: 本發明用於生髮用品中的氮劑爲亞硝酸鹽或者經過濃縮的富含亞硝酸鹽的植物 提液，配以相應的基質輔料進行混和，乳化，滅菌，灌裝爲不同劑型、不同功效的生 髮產品。其中，亞硝酸鹽優選亞硝酸鈉。 # 本發明的酸劑： 本發明用於生髮用品的酸劑爲有機酸，如：一水檸檬酸、馬來酸等或者無機酸， 如硼酸等，配以相應的基質輔料進行混和，攪拌，滅菌，灌裝爲不同劑型、不同功效 的生發配製品。 上述的氮劑和酸劑所用的基質輔料與現有的生髮產品使用的成份基本上是相同 的。例如使用硬脂酸、·矽油、二甲基矽氧院等作柔軟劑，使用甘油、透明質酸、小麥 胚芽油、丙二醇等作保濕劑，使用十六醇、十八醇、單硬脂酸甘油酯、乙二胺四醋酸 二鈉、十八烷氧基三甲基砂烷(與)硬脂醇、鋁澱粉丁二酸辛烯酯等作乳化劑，使用羥 乙基纖維素、白油、黃原膠、氫化蓖麻油、肉豆蔻酸辛基十二烷醇酯等作增稠劑，使 用布羅波爾、尼泊金甲酯、尼泊金丙酯等作防腐劑，使用綠茶香精等作香料，使用 VE乙酸酯作抗氧劑；使用西洋參、紅花、薄荷等提取液爲中藥提取物等。基晳中各 成分的用量也大體與現有的生髮用品相同。 本發明產品的主劑、基質用量按重量百分比的範圍： 1、氮劑 (1)活性成分亞硝酸鹽（亞硝酸鈉或者含亞硝酸鹽的植物濃縮液）〇·〇1 %〜1 ·〇% 5 200841886 . (2)生髮用品基質： 1〜90% (3)餘量是水； 2、酸劑 (1) 活性成分抗壞血酸、馬來酸、一7jc檸檬酸、硼酸中的一種或多種〇·〇1%〜2·0 % (2) 生髮用品基質： 1-90% ⑶餘量是水。 還可含有其他常用生髮用品成份，如：中和劑、表面活性劑、蠟、防曬劑、維生素類、 抗皺活性成分等 用法用量： 該生髮用品分爲兩部分，氮劑和酸劑。 ^潔脫髮處頭皮，擦乾脫髮處頭皮後，將豆粒大小的氮劑均勻塗抹到脫髮處頭皮， 再將豆粒大小的酸劑均勻塗抹到脫髮處頭皮，同時用手指在脫髮區做輕度按摩，以增加 液劑的滲透，促進吸收，利於發揮效果。 使用注意事項： 響 在使用該生髮用品時，將酸劑和氮劑接觸，並儘量保證先塗氮劑於皮膚再塗酸劑。 這是因爲： 卜酸劑和氮劑接觸後便可在局部釋放一氧化氮，避免細菌感染，達到消炎、提高皮膚 局部免疫力、止脫髮效果的同時，又可舒張局部血管、疏通毛囊、促進毛髮的生長。 2、由於酸劑近外界，酸劑具有還原能力，降低了新產生的一氧化氮被氧化的可能性。 * 貯藏: 密閉，置陰涼乾燥處保存。 【實施方式】 實施例僅爲本發明的較佳實施例而已，當不能以此限定本發明的範圍。大體上依本 • 發明申請專利範圍所作的均等變化與修飾，即在各種生髮產品中溶入一氧化氮生成技 術，製得的不同組成配方、不同劑型的生髮產品，皆應仍屬本發明專利涵蓋的範圍內。 所列實施例均爲本發明產品的最佳組方之一，用量按重量百分比記，其中氮劑的有 效成分除所舉亞硝酸鈉外也可用含亞硝酸鹽的菠菜提取液等的植物提取液。 方案一：適用于美容、健髮 -7 y 酸】 m 成分名稱（％) 用量（％) 成分名稱（％) 用量（％) 亞硝酸鈉 0.04 抗壞血酸 0.04 I EDTA ^ 0.2 水楊酸 0.5 200841886 甘油 3.0 丙二醇 0.1 羥乙基纖維素 0.1 羥乙基纖維素 0.1 香精_ 0.1 香精 0.1 去離子水 餘量 去離子水 餘量 方案二:針對由於工作、生活壓力大，精神緊張而大量掉髮的人群： NS !1 酸3 m 成分皂稱（％) 用量（％) 成分名Μ (%) 用量（柘） 亞硝酸鈉 0.2 抗壞血酸 0.4 薄荷醇 0.2 橄攬油 5.0 辣椒酊 0.2 甘草酸 0.1 液體石蠟 10.0 乙醇 50.0 尼泊金甲酯 0.1 尼泊金甲酯 0.1 香精 0.1 香精 0.1 去離子水 餘量 去離子水 餘量 方案三··適用於稍禿人群： N劑 酸劑 成分名稱（％) 用量（％) 成分名稱（％) 用量（％) 亞硝酸鈉 0.4 抗壞血酸 0.8 生物素 0.005 硼酸 5.0 D—泛醇 0.2 維生素E煙酸酯 0.01 樟腦 0.1 濃縮甘油 50.0 尼泊金丙酯 0.1 尼泊金丙酯 0.1 薄荷香精 0.1 薄荷香精 0.1 去離子水 餘量 1去離子水 餘量 方案四：適用於秕糠性脫髮症（重在消炎）: N剤 | 酸劑 成分名稱（％) 用量（％) 成分名稱（％) 用量（％) 亞硝酸鈉 0.6 抗壞血酸 1 200841886 長壓定 0.005 L 一胱氨酸 0.01 固體石蠟 3.0 尿囊素 0.03 尼泊金丁酯 0.1 水楊酸脂矽烷醇C 0.1 薄荷香精 0.1 尼泊金丁酯 0.1 去離子水 餘量 薄荷香精 0.1 去離子水 滕里 方案五:適用于脫髮較嚴重人群（俗稱地中海): NS 3 酸】 削 成分名稱（％) 用量（％) 成分名稱（％) 用量（％) 亞硝酸鈉 1 抗壞血酸 1.5 葡萄籽油 3.0 馬來酸 0.6 乙醇 2.0 液體石蠟 10.0 尼泊金乙酯 0.1 尼泊金乙酯 0.1 香精 0.1 香精 0.1 去離子水 餘量 去離子水 餘量 方案六：適用于全禿人群： a 酸】 削 成分名稱（％) 用量（％) 成分名稱（％) 用量（％) 亞硝酸鈉 2 抗壞血酸 1.2 胎盤水溶膠 15.0 異丙醇 21.7 乙醇 22.0 羥乙基纖維素 0.4 尼泊金乙酯 0.1 脂肪醇 50.0 香精 0.1 尼泊金乙酯 0.1 羥乙基纖維素 0.4 香精 0.1 去離子水 滕里 去離子水 餘量 方案七：適用於脂溢織 ΝΙ « _ II 酸! _ 成分名稱（％) 用量（％) 1成分名稱（％) 用量（％) 亞硝酸鈉 1.8 I 抗壞血酸 2.0 200841886 Γ 0.15 VB6 0.15 腺苷三磷酸鹽 0.01 水楊酸 0.2 肌醇 0.1 薄荷醇 0.1 尼泊金乙酯 0.1 尼泊金乙酯 0.1 香精 0.1 香精 0.1 1去離子水 餘里 去離子水 餘量 以上實施例所列氮劑和酸劑的製備過程均爲：按表中所列從上至下的順序，將各組 分依次加入水中，混和攪拌，使其完全溶解，然後靜置使溶液變澄清，在無菌狀態下進 行分裝。 【圖式簡單說明】 圖1爲生髮用品包括兩個體系：以含有亞硝酸鹽爲原料的氮劑②和以維生素C、有 機酸或無機酸爲原料的酸劑①，當二者聯合作用於脫髮處頭部皮膚組織⑧，可以產 生適量的N0④ 【主要元件符號說明】 ① 代表含有以維生素C、有機酸或無機酸爲原料的酸劑； ② 代表含有有亞硝酸鹽的氮劑； ③ 代表脫髮處頭部皮膚組織； ④ 代表一氧化氮Nitric oxide is a vasodilating component that allows blood vessels to relax, thereby increasing blood flow and promoting blood circulation, which is a function of boosting blood circulation and oxygen supply. Nitric oxide is a very small lipophilic molecule that rapidly diffuses through the biofilm barrier by paracrine action, reaches adjacent target cells, and is linked to the ferrous hemoglobin portion of the guanylate cyclase in the cell, causing The enzyme is initiated to increase the conversion of guanosine triphosphate to c-guanosine monophosphate (cGMP) by 50-200 fold, resulting in an increase in intracellular cGMP. cGMP then initiates a GMP-dependent protein kinase or a calcium channel that acts directly on the cell membrane, causing calcium ion efflux or intracellular free calcium binding, thereby allowing smooth muscle cell relaxation and vasodilation, in the process, cGMP 4 200841886 plays the role of the second messenger. At the same time, GMP also inhibits platelet aggregation and adhesion of blood/Jx® to the vascular endothelium. Nitric oxide synthesis is involved in the non-specific defense of several pathogens. Macrophages, etc., can synthesize and release nitric oxide at the initiation or under certain pathological conditions, and cause cytotoxicity, inhibiting TCA, electron transport and cellular DNA synthesis in target cell mitochondria, producing bacteria, fungi and tumor cells. Its killing effect promotes acute inflammatory reaction of tissues, participates in tissue damage and wound healing, thereby causing tissue damage and/or cell necrosis, killing bacteria, viruses, parasites and tumor cells. Nitric oxide is a vasodilating component that allows blood vessels to relax, thereby increasing blood flow and promoting blood circulation. SP has the function of increasing local blood circulation and oxygen supply, and at the same time, because of nitric oxide against bacteria, fungi, and parasitic Insects and tumor cells have a killing effect. The head lice, which is the culprit of hair loss, is a tiny animal that is parasitic on the scalp. They are parasitic in human hair follicles, feed on sebum, secrete lipolytic enzymes, invade sebaceous glands, and block hair follicles. The most common one is Pityrosporum, one of the fungi, which causes one of the causes of JI-induced alopecia. At present, there are no reports of nitric oxide-based hair growth products. SUMMARY OF THE INVENTION The object of the present invention is to provide a kind of nitric oxide to promote the relaxation of blood vessels in the brain, thereby increasing the blood supply and oxygen supply of the hair follicle, and simultaneously cleaning and repairing the hair follicle, thoroughly improving the hair follicle itself and the surrounding environment, and enhancing The overall growth of the head hair, and does not produce hair growth, hair loss prevention, hair growth and cosmetic hair growth preparations. The present invention is achieved by the following technical solutions: The present invention is a health care product and a special hair care product based on nitric oxide capable of improving the quality of hair follicles, and is composed of a nitrogen agent and an acid agent. Among them: the nitrogen agent is made up of nitrite or a plant extract containing nitrite; the acid agent is made of an organic acid or an inorganic acid. When the nitrogen agent and the acid agent are combined, the active ingredient, nitric oxide, can be released locally and in a controlled manner. The two-part type hair growth preparation of the invention and the manufacturing process thereof: The nitrogen agent of the invention: The nitrogen agent used in the hair growth product of the invention is nitrite or concentrated nitrite-rich plant extract with corresponding The matrix excipients are mixed, emulsified, sterilized, and filled into hair growth products of different dosage forms and different functions. Among them, the nitrite is preferably sodium nitrite. The acid agent of the present invention is an organic acid used in the hair growth product, such as: citric acid monohydrate, maleic acid, etc. or inorganic acid, such as boric acid, etc., mixed with the corresponding matrix auxiliary materials, and stirred. Sterilize and fill the hair growth preparations with different dosage forms and different functions. The matrix adjuvants used in the above nitrogen and acid agents are substantially the same as those used in existing hair growth products. For example, stearic acid, eucalyptus oil, dimethyl oxime or the like is used as a softening agent, and glycerin, hyaluronic acid, wheat germ oil, propylene glycol or the like is used as a humectant, and cetyl alcohol, stearyl alcohol, and monostearic acid are used. Glycerin, disodium edetate, octadecyloxytrimethyl sane (and) stearyl alcohol, aluminum starch octyl octyl acrylate, etc. as emulsifier, using hydroxyethyl cellulose, white oil, Xanthan gum, hydrogenated castor oil, octyldodecanol myristate, etc. as a thickener, using bromopol, methylparaben, propylparaben, etc. as a preservative, using green tea flavor, etc. For the fragrance, VE acetate is used as an antioxidant; and an extract such as American ginseng, safflower or peppermint is used as a traditional Chinese medicine extract. The amount of each component in Kiwi is also generally the same as that of existing hair care products. The dosage of the main agent and the substrate of the product of the invention is in the range of percentage by weight: 1. Nitrogen agent (1) active ingredient nitrite (sodium nitrite or plant concentrate containing nitrite) 〇·〇1%~1 ·〇 % 5 200841886 . (2) Hair care product base: 1~90% (3) The balance is water; 2. Acid agent (1) One or more of the active ingredients ascorbic acid, maleic acid, a 7jc citric acid, boric acid ·〇1%~2·0 % (2) Hair care product base: 1-90% (3) The balance is water. It can also contain other commonly used hair care ingredients, such as: neutralizers, surfactants, waxes, sunscreens, vitamins, anti-wrinkle active ingredients, etc. Dosage: The hair products are divided into two parts, nitrogen and acid. ^ Clean the hair on the scalp, dry the scalp of the hair loss, evenly spread the nitrogen of the bean size to the scalp of the hair loss, then evenly spread the sour bean size to the scalp of the hair loss, while using the finger to do a light massage in the hair loss area In order to increase the penetration of the liquid agent, promote absorption, and facilitate the effect. Precautions for use: When using the hair care product, contact the acid agent and the nitrogen agent, and try to ensure that the nitrogen agent is applied to the skin before the acid is applied. This is because: After the acid agent and the nitrogen agent are in contact, the nitric oxide can be released locally to avoid bacterial infection, and the anti-inflammatory, skin local immunity and hair loss effect can be achieved, and the local blood vessels can be relaxed, the hair follicle can be cleared, and the hair follicle can be promoted. Hair growth. 2. Because the acid agent is close to the outside, the acid agent has the reducing ability, which reduces the possibility of newly generated nitric oxide being oxidized. * Storage: Store in a cool, dry place. [Embodiment] The embodiments are merely preferred embodiments of the present invention, and the scope of the present invention is not limited thereto. In general, according to the scope of the invention patent application, the equal variation and modification, that is, the nitric oxide production technology is dissolved in various hair growth products, and the different composition formulas and different dosage forms of the hair growth products are still the patents of the present invention. Covered by the scope. The listed examples are all one of the best compositions of the product of the present invention, and the dosage is recorded by weight percentage, wherein the active ingredient of the nitrogen agent can be extracted from plants such as spinach extract containing nitrite in addition to sodium nitrite. liquid. Solution 1: Applicable to beauty, health -7 y acid] m ingredient name (%) dosage (%) ingredient name (%) dosage (%) sodium nitrite 0.04 ascorbic acid 0.04 I EDTA ^ 0.2 salicylic acid 0.5 200841886 glycerol 3.0 Propylene glycol 0.1 hydroxyethyl cellulose 0.1 hydroxyethyl cellulose 0.1 Fragrance _ 0.1 Fragrance 0.1 Deionized water balance Deionized water balance Option 2: For people who have a large amount of hair loss due to work and life stress, nervousness: NS !1 Acid 3 m Ingredients Soap (%) Dosage (%) Ingredient name % (%) Dosage (柘) Sodium nitrite 0.2 Ascorbic acid 0.4 Menthol 0.2 Olive oil 5.0 Capsicum 0.2 Glycyrrhizic acid 0.1 Liquid paraffin 10.0 Ethanol 50.0 Ni Potassium methyl ester 0.1 Nipagin methyl ester 0.1 Fragrance 0.1 Fragrance 0.1 Deionized water balance Deionized water balance scheme III·Applicable to slightly bald people: N agent acid ingredient name (%) Dosage (%) Ingredient name (%) Dosage (%) Sodium nitrite 0.4 Ascorbic acid 0.8 Biotin 0.005 Boric acid 5.0 D-Panthenol 0.2 Vitamin E Nicotinate 0.01 Camphor 0.1 Concentrated Glycerin 50.0 Nipagin C 0.1 propyl paraben 0.1 Mint essence 0.1 Mint essence 0.1 Deionized water balance 1 Deionized water balance Option 4: Suitable for spastic alopecia (heavier in anti-inflammatory): N剤 | Acid ingredient name (%) Dosage (%) Ingredient name (%) Dosage (%) Sodium nitrite 0.6 Ascorbic acid 1 200841886 Long press 0.005 L Cysteine 0.01 Solid paraffin 3.0 Allantoin 0.03 Parabens 0.1 Salicyl sulphate C 0.1 Mint Flavor 0.1 Nipa Gold Butadiene 0.1 Deionized Water Balance Mint Flavor 0.1 Deionized Water Tengli Scheme 5: Suitable for people with severe hair loss (commonly known as the Mediterranean): NS 3 acid] Name of ingredients (%) Usage (% Ingredient name (%) Dosage (%) Sodium nitrite 1 Ascorbic acid 1.5 Grape seed oil 3.0 Maleic acid 0.6 Ethanol 2.0 Liquid paraffin 10.0 Nipagin ethyl ester 0.1 Nipagin ethyl ester 0.1 Fragrance 0.1 Fragrance 0.1 Deionized water balance Deionized Water Balance Scheme 6: Applicable to all bald people: a Acid】 Shaved ingredient name (%) Dosage (%) Ingredient name (%) Dosage (%) Sodium nitrite 2 Ascorbic acid 1.2 Placenta hydrosol 15.0 Isopropanol 21.7 Ethanol 22.0 Hydroxyethyl cellulose 0.4 Nipagin ethyl ester 0.1 Fatty alcohol 50.0 Fragrance 0.1 Nipagin ethyl ester 0.1 Hydroxyethyl cellulose 0.4 Fragrance 0.1 Deionized water Tengli deionized water Balance 7: Apply to lipid raft ΝΙ « _ II acid! _ ingredient name (%) dosage (%) 1 ingredient name (%) dosage (%) sodium nitrite 1.8 I ascorbic acid 2.0 200841886 Γ 0.15 VB6 0.15 adenosine Triphosphate 0.01 Salicylic acid 0.2 Inositol 0.1 Menthol 0.1 Nipagin ethyl ester 0.1 Nipagin ethyl ester 0.1 Fragrance 0.1 Fragrance 0.1 1 Deionized water Residual deionized water balance Nitrogen and acid listed in the above examples The preparation process of the agent is as follows: in the order from top to bottom listed in the table, the components are sequentially added to the water, mixed and stirred to completely dissolve, and then allowed to stand to make the solution clear, and the mixture is sterilized under aseptic conditions. . BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 shows a hair growth product comprising two systems: a nitrogen agent containing nitrite as a raw material 2 and an acid agent 1 using vitamin C, an organic acid or a mineral acid as a raw material, when the two are used in combination Hair tissue at the head of the hair loss 8 can produce an appropriate amount of N04 [Main component symbol description] 1 represents an acid agent containing vitamin C, organic acid or inorganic acid as raw material; 2 represents a nitrogen agent containing nitrite; 3 represents Hair tissue at the head of the hair loss; 4 represents nitric oxide