TW200824662A - Limited reuse assembly for ophthalmic injection device - Google Patents

Limited reuse assembly for ophthalmic injection device Download PDF

Info

Publication number
TW200824662A
TW200824662A TW096138456A TW96138456A TW200824662A TW 200824662 A TW200824662 A TW 200824662A TW 096138456 A TW096138456 A TW 096138456A TW 96138456 A TW96138456 A TW 96138456A TW 200824662 A TW200824662 A TW 200824662A
Authority
TW
Taiwan
Prior art keywords
assembly
actuator
interface
controller
pair
Prior art date
Application number
TW096138456A
Other languages
Chinese (zh)
Inventor
Bruno Dacquay
Cesario Dos Santos
James Foster
Casey Lind
Raffi Pinedjian
Robert Sanchez
Original Assignee
Alcon Mfg Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/832,364 external-priority patent/US20070270744A1/en
Application filed by Alcon Mfg Ltd filed Critical Alcon Mfg Ltd
Publication of TW200824662A publication Critical patent/TW200824662A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A61M5/445—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media the media being heated in the reservoir, e.g. warming bloodbags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6027—Electric-conductive bridges closing detection circuits, with or without identifying elements, e.g. resistances, zener-diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1413—Modular systems comprising interconnecting elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Prostheses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A limited reuse assembly for an ophthalmic medical device has an actuator with a shaft, a power source for providing power to the actuator, a controller for controlling the actuator, a mechanical linkage interface, and a housing. The mechanical linkage interface is coupled to the actuator shaft and has a mating surface on one end. The housing at least partially encloses the power source, the controller, and the actuator. The limited reuse assembly is attachable to and removable from a disposable injection device.

Description

200824662 九、發明說明： 【發明戶斤屬之技術領域】 相關申請案 此申請案係主張2006年10月16日提申的美國專利申& 案60/9215497、2006年10月16曰提申的美國專利申锖: 60/921，498、及2006年10月16日提申的美國專利申:; 60/921，499之優先權，且身為及2〇〇6年5月17日提申的:: 專利申請案11/435,906之部分接續案。 、果國 發明背景 10 15 20 本發明有關一單次使用醫療骏置且更特別有關一一 式眼用藥物輸送裝置，其具有-含有―經改良的柱塞3 及密封件之可拋棄式梢端。 干 L· 眼睛後段的數種疾病及狀況會威脅視力。年齡相關险 斑點退化(ARMD)、脈絡膜新生金管 如，糖尿病性視網膜病變、玻璃體視網膜病變）、視網 (譬如巨細胞病毒(CMV)視網膜炎）' 葡萄膜炎、主立、人 斑部水 腫、青光眼、及神經病變係為數項範例。 可將藥物注射至眼中藉以治療這些及其他疾病。此等 注射通常利用一習知注射器及針頭以人工進 J。弟1圖為一 用來將藥物注射至眼中之先前技藝注射器的立體圖。第^圖 中，注射器包括一針頭105，——路厄轂11〇，—〜 ° — 至115，一柱 基120，-柱塞軸125，及-姆指靠座⑽。如通常所知，受 注射藥物位居室115中。姆㈣座13吐的推押係造成柱塞 5 200824662 120經由針頭105驅出藥物。 使用此注射器時，外科醫師需以針頭穿刺眼組織，穩 定固持住注射器，且致動注射器柱塞(在有或無護士幫助下) 以將流體注射至眼中。因為注射器上的游標尺對於小注射 5容積而言並不精密，所注射容積通常未以精確方式被控 制。流體流率未受控制。游標尺讀取亦受到視差誤差。可 能由於“不穩定，，注射而發生組織損害。當針頭自眼睛移除 時’亦可能發生藥物逆流。 已致力控制小量液體的輸送。一種市售的液體配送器 10係為得自羅德島普羅旺斯的FED公司（FED Inc·)之 ULTRA™確動位移配送器。uutra配送器通常用來配送小 置工業黏劑。其利用一習知注射器及一定製配送梢端。注 射器梢端利用一電步進馬達及一致動流體被致動。俄亥俄 州克利夫蘭的帕可漢那芬公司（Parker200824662 IX. Description of the invention: [Technical field of invention of the family] Related application This application claims to be filed on October 16, 2006, US Patent Application & 60/9215497, October 16, 2006 U.S. Patent Application No. 60/921,498, and US Patent Application No. 60/921,499, filed on Oct. 16, 2006, and which is filed on May 17, 2002. Shen's: Part of the patent application 11/435,906. BACKGROUND OF THE INVENTION The present invention relates to a single use medical device and more particularly to a one-way ophthalmic drug delivery device having a disposable tip containing an improved plunger 3 and a seal end. Dry L· Several diseases and conditions in the posterior segment of the eye can threaten vision. Age-related risk spot degeneration (ARMD), choroidal neonatal gold tube such as diabetic retinopathy, vitreoretinopathy, and visual network (such as cytomegalovirus (CMV) retinitis) uveitis, main, human edema, Glaucoma, and neuropathy are several examples. Drugs can be injected into the eye to treat these and other diseases. Such injections are typically performed manually using a conventional syringe and needle. Figure 1 is a perspective view of a prior art syringe for injecting a drug into the eye. In the figure, the syringe includes a needle 105, a luer hub 11 〇, - ° ° - to 115, a column base 120, a - plunger shaft 125, and a thumb socket (10). As is generally known, the injectable drug is located in chamber 115. The pushing of the 13th spit causes the plunger 5 200824662 120 to drive the drug out through the needle 105. When using this syringe, the surgeon needs to puncture the ocular tissue with a needle, securely hold the syringe, and actuate the syringe plunger (with or without the help of a nurse) to inject fluid into the eye. Because the vernier scale on the syringe is not precise for small injections of 5 volumes, the injected volume is usually not controlled in an accurate manner. The fluid flow rate is not controlled. The vernier scale reading is also subject to parallax error. Probably due to "unstable, tissue damage due to injection. Drug reversal may occur when the needle is removed from the eye." Efforts have been made to control the delivery of small amounts of liquid. A commercially available liquid dispenser 10 is derived from Rhodes. Ful Inc. (FED Inc.) ULTRATM Actuator Displacement Dispenser. Uutra Dispenser is commonly used to dispense small industrial adhesives. It utilizes a conventional syringe and a custom dispensing tip. Electric stepper motor and consistent fluid are actuated. Parker Hannover, Cleveland, Ohio (Parker

Hannifin Corporation) 15係分銷加州聖地牙哥的歐羅拉儀器公司（Aurora Instmments LLC)製造之一用於藥物發現應用的小量液體 配送器。帕可/歐羅拉配送器利用一壓電_電性配送機構。瑞 士的且梭梅公司（Ypsomed，Inc.)生產主要用於患者胰島素 或激素自行注射之一產品線的注射筆及自動化注射器。此 2〇產品線包括簡單可拋棄式筆及電控制式機動化注射器。 美國專利案6,290,690揭露一在手術期間於一流體/流 體父換中將一黏性流體（譬如矽氧油）注射至眼中同時自眼 目月吸出第二黏性流體（譬如氟化複液體）以修護視網膜脫離 或撕裂之眼用系統。該系統包括一含有一柱塞之習知注射 200824662 器。注射器的一端流體式耦合至一用於提供恆定氣動壓 以致動柱塞之氣動壓力源。注射器另一 ^ 、卜、 田官件流體式 编合至一灌注插管以輸送待注射黏性流體。 5Hannifin Corporation) The 15 Series distributes a small volume of liquid dispensers for drug discovery applications manufactured by Aurora Instmments LLC of San Diego, California. The Parco/Eurora dispenser utilizes a piezoelectric-electrical dispensing mechanism. Ypsomed, Inc. produces injection pens and automated syringes for use in one of the patient's insulin or hormone self-injection lines. This 2-inch product line includes simple disposable pens and electrically controlled motorized syringes. U.S. Patent No. 6,290,690 discloses the application of a viscous fluid (such as a sulphuric acid) to the eye during a fluid/fluid parent exchange during surgery to simultaneously aspirate a second viscous fluid (such as a fluorinated complex liquid) from the eye to repair. An eye system that protects the retina from detachment or tear. The system includes a conventional injection 200824662 containing a plunger. One end of the injector is fluidly coupled to a pneumatic pressure source for providing a constant pneumatic pressure to actuate the plunger. The other syringe, the fluid, is fluidly coupled to a perfusion cannula to deliver the viscous fluid to be injected. 5

10 希望具有—用於將一藥物注射至眼中之可攜式手件， 其包括-可附接至及移除自—可重覆使用總成之相對較便 宜的梢端分段。將包括電子件及—驅動機構等較昂責組件 放置在可重覆使用絲巾同時將錢崎料在梢=總成 中之作料改良-藥物輸送祕的效率及成本效益。希望 具有一含有用於注射程序的組件及機能之可重:使用= 成。亦希望具有—可拋棄式梢端分段，討容易地附接至 可重覆使用總成以供注射，然後在注射之後容易地移除及10 It is desirable to have a portable handpiece for injecting a drug into the eye, which includes - a relatively inexpensive tip segment that can be attached to and removed from the reusable assembly. The more cost-effective components, including electronic components and drive mechanisms, can be placed on the reusable silk scarves while improving the efficiency of the drug delivery in the tip = assembly. It is desirable to have a component that contains the components and functions for the injection procedure: use =. It is also desirable to have a disposable tip segment that can be easily attached to a reusable assembly for injection and then easily removed after injection and

棄置°此系、统提供優於先前技藝崎^的許多利益。 【發明内容】 I 發明概要Disposal of this system provides many advantages over the prior art. SUMMARY OF THE INVENTION I Summary of the Invention

與本發明原理呈現一致之一實施例中，本發明為一有 限重覆使用總成，其具有-包含一轴之致動器，一用於將 二率提供至致動ϋ之功率源，_料控制致動器之控制 斋:-機械連桿介面，及-殼體。機械連桿介面·合至致 加動二軸且在一端上具有一對接表面。殼體至少部份地包圍 力率源控制斋、及致動器。有限重覆使用總成可附接至 及移除自一可拋棄式注射裝置。 與本發明原理呈現一致之另一實施例中，本發明為一 有限重覆使用總成，其具有一包含一軸之致動器，一用於 等力率提供至致動器之功率源，一用於控制致動器之控制 7 200824662 器，-機械連桿介面，一殼體，及一指示器。機械連桿介 面柄合至致動器軸且在_端上具有一對接表面。殼體至少 部份地包圍功率源、控制器、及致動器。指示器設置於殼 體上且提供有關該有限重覆使用總成的一狀態之資訊。控 5制器控制致動器的操作以使致動器驅動致動器輛以將一劑 - 量的一物質輸送至一眼中。 w 明瞭解上述一般描述及下列詳細描述只是示範性及說 馨明性且預定提供所主張之本發明的進一步說明。下文描述 及本發明的貫行係提出且提議本發明之額外優點及目的。 10圖式簡單說明 被併入本說明書且構成其一部份之圖式係顯示本發明 _ 的數項實施例且連同該描述用來說明本發明之原理。 、 第1圖為一先前技藝注射器之立體圖； 第2圖為根據本發明的一實施例之包括一可拋棄式梢 15端分段及一有限重覆使用總成之眼用醫療裝置的圖式； • 第3圖為根據本發明原理之一有限重覆使用總成的另 一實施例； 、 第4圖為根據本發明原理之一有限重覆使用總成的另 一實施例之橫剖視圖； 20 第5圖為根據本發明的一實施例之一可拋棄式梢端分 段及一有限重覆使用總成的橫剖視圖； 第6圖為根據本發明的一實施例之一用於_眼用醫療 裴置之可拋棄式梢端分段的橫剖視圖； 弟7圖為根據本發明的一實施例之一用於一眼用醫療 8 200824662 裝置之可抛棄式梢端分段的橫剖視圖； 第8圖為根據本發明的-實施例之—可拋棄式梢端分 橫剖視圖及一有限重覆使用總成的部份圖· 第9A圖為根據本發明的一實施例 、 用於一眼用醫療 5衣置之可拋棄式梢端分段的橫剖視圖； 第9B圖為第9A圖的實施例之端視圖； 第1〇Α-1_為可被包括在根據本發明的實施例中之 四個不同電路的示意圖。 第11圖為根據本發縣理之-有限重€使㈣成_ 10 視圖， 第12圖為根據本發明的-實施例之一有限重覆使用總 成的橫剖視圖； 第13圖為根據本發明的-實施例之一有限重覆使用總 成的橫剖視圖； 15 第14及15®為根據本發明原歡兩★總成的橫剖視 圖， 第16圖為根據本發明原理之-有限重覆使用總成、梢 端分段、及一充電基底的橫剖視圖； 第17A及17B圖為根據本發明原理之一用於將一物質 20 注射至一眼中之方法的流程圖； 第18圖為根據本發明原理之一有關將—物質注射至一 眼中之方法的流程圖； 第19圖為根據本發明原理之一有關將〜物質注射至一 眼中之方法的流程圖； 9 200824662 第20圖為根據本發明原理之一有關將一物質注射至一 眼中之方法的流程圖。 【實施方式3 較佳實施例之詳細說明 5 現在詳細參照本發明的示範性實施例，其範例顯示於 - 圖中。若可能則在各圖中使用相同編號來代表相同或相似 的部份。 _ 第2圖為根據本發明的一實施例之一包括一可拋棄式 梢端分段及一有限重覆使用總成之眼用醫療裝置的圖式。 1〇第2圖中，醫療裝置包括一梢端分段205及一有限重覆使用 總成250。梢端分段2〇5包括一針頭210，一殼體215，及一 . 選用性燈光275。有限重覆使用總成250包括一殼體255，一 開關270，一鎖機構265，及一螺紋式部分260。 梢端分段205能夠被連接至及移除自有限重覆使用總 15成250。此實施例中，梢端分段205具有一位於殼體215的一 φ 内部表面上之螺紋式部分，其螺接至有限重覆使用總成250 ‘ 的螺紋式部分260上。此外，鎖機構265將梢端分段215固接 至有限重覆使用總成250。鎖機構265可為一按鈕、一滑動 開關、或一懸臂式機構的形式。其他用於將梢端分段205連 20接至有限重覆使用總成25〇之機構、諸如包含彼此對接的結 構性特徵結構者通常係為該技藝已知且位於本發明範圍 内。 針頭210適可將一諸如藥物等物質輸送至一眼中。針頭 210可為任何常見的已知組態。較佳將針頭2⑺設計成使其 10 200824662 熱性特徵有助於特定藥物輸送應用。譬如，當將輸送—經 加熱藥物時，針頭210可能為相對較短(數公厘）長度(對於= 性用途）以便利藥物的妥當輸送。 開關270適可將一輸入提供至系統。譬如，可利用開關 5 270來啟⑽、統或接通_溫度控職置。其他制、按紐、 “ 或使用者導引式控制輪入通常係為已知且可能配合使用有 限重覆使用總成250及/或梢端分段2〇5。 _ 當梢端分段205就緒可供使用時，選用性燈光275亮 起。選用性燈光275可自殼體215突起，或者其可被圍堵於 10殼體内’在該例中，選用性燈光275可經由殼體215的一 無色部分被看見。其他實施例中，選用性燈光275可由一指 示器取代，諸如一液晶顯示器、分段式顯示器、或用於指 示可拋棄式梢端分段205狀態或狀況之其他裝置。譬如，選 用性燈光275可明滅脈動以指示其他狀態，諸如但不限於一 15 系統錯誤、完全充電的電池、充電不足的電池或梢端分段 ^ 205及有限重覆使用總成250之間的錯誤連接。雖然顯示位 於梢端分段205上，選用性燈光275或一額外指示器可設置 ^ 於有限重覆使用總成250上。 w 第3圖為根據本發明原理之一有限重覆使用總成的另 20 一實施例。有限重覆使用總成250包括一按鈕308、一顯示 器320、及一殼體330。可拋棄式梢端分段205附接至有限重 覆使用總成250之端340。按鈕308被致動以將一輸入提供至 系統。如同開關270，按鈕308可啟動一溫度控制裝置或引 發一柱塞的致動。顯示器320係為一液晶顯示器、分段式顯 11 200824662 示器、或用於指示可拋棄式梢端分段205或有限重覆使用總 成250的狀態或狀況之其他裝置。 第4圖為根據本發明原理之一有限重覆使用總成的另 一實施例之橫剖視圖。第4圖中，功率源5〇5、介面517、致 5 動器515、及致動器軸510設置於殼體255中。殼體255的頂 部份具有一螺紋式部分260。鎖機構265、開關270、按崔丑 308、及指示器306、307皆設置於殼體255上。 功率源505通常為一諸如鋰離子電池等可再充電式電 池，但可採用其他類型電池。此外，任何其他類型功率胞 10 元係適合功率源505。功率源505將功率提供至系統，且更 特別提供至致動器515。功率源505亦將功率提供至一連接 至有限重覆使用總成250之梢端分段。在此例中，功率源505 可將功率提供至一設置於梢端分端中之溫度控制裝置（未 圖示）。選用性地，功率源505可經由一門或其他類似特徵 15 結構(未圖示）自殼體255移除。 介面517通常為一可容許功率自功率源505流至致動器 515之電導體。亦可出現如介面517之其他介面以將％率提 供至系統的其他部份。 致動器軸510連接至致動器515且被其驅動。致動器515 20 通常為一步進馬達或能夠將致動器軸510移動確切距離之 其他類型馬達。一實施例中，致動器軸510經由機械連桿連 接至一梢端分段藉以將一藥物輸送至一眼中。在此例中， 致動器515為一可確切地移動軸510之步進馬達以將一確切 數量的藥物輸送至眼中。致動器515譬如藉由用於接合致動 12 200824662 器515外表面之籤片被固接至殼體255的一内部表面。 其他實施例中，致動器515為一線性致動器或線性驅動 器。在此例中，致動器515可為一彈簧或彈簧驅動式機構， 一具有一旋轉感測器之耦合至一線性傳動器的齒輪式DC 5馬達，或一具有一線性感測器之耦合至一線性傳動器的DC 馬達，或一線性步進馬達。亦可對於致動器515使用如旋轉 永久性磁鐵馬達之其他類型馬達。 鎖機構265、開關270、及按紐308皆設置於殼體255上 使其可由手操縱。同理，指示器306、307設置於殼體255上 10 使其可被觀視。鎖機構265、開關270、按鈕308、及指示器 306、307亦經由設置於殼體255中的介面（未圖示）連接至一 控制器（未圖示）。 弟5圖為根據本發明的一貫施例之一可抛棄式梢端分 段及一有限重覆使用總成的橫剖視圖。第5圖顯示梢端分段 15 205如何與有限重覆使用總成250形成介面。第5圖的實施例 中，梢端分段205包括總成555、柱塞介面420、柱塞415、 配送室殼體425、梢端分段殼體215、溫度控制裝置450、熱 感測器460、針頭210、配送室405、介面530、及梢端介面 連接器453。有限重覆使用總成250包括機械連桿介面545、 20 致動器軸510、致動器515、功率源505、控制器305、有限 重覆使用總成殼體255、介面535、及有限重覆使用總成介 面連接器553。 梢端分段205中，柱塞介面420設置於柱塞415的一端 上。柱塞415的另一端形成配送室405的一端。柱塞415適可 13 200824662 滑動於配送室405内。柱塞415的外表面流體式密封至配送 室殼體425的内表面。配送室殼體425圍繞配送室4〇5。一般 而吕，配送室殼體425具有一圓柱形狀。因此，配送室 亦具有一圓柱形狀。梢端分段205中，總成555包括任何數 5 量的組件，如下述。 針頭210流體式箱合至配送室4〇5。在此例中，一被圍 堵於配送室405中的物質可穿過針頭21〇且進入一眼中。溫 度控制裝置450至少部份地圍繞配送室殼體425。在此例 中’溫度控制裝置450適可加熱及/或冷卻配送室殼體425及 10被圍堵於配送室405中的任何物質。介面530使溫度控制裝 置450連接於梢端介面連接器453。 梢端分段205的組件、包括配送室殼體425、溫度控制 裝置450、及柱塞415係至少部份地被梢端分段殼體215包 圍。與本發明原理呈現一致之一實施例中，柱塞415被密封 15至配送室殼體425内部表面。此密封係防止被圍堵於配送室 405中之任何物質的污染。對於醫療用途，希望有此密封。 此密封可設置於柱塞415或配送室殼體425上的任何點。 有限重覆使用總成250中，功率源505將功率提供至致 動器515。一位於功率源505與致動器515之間的介面（未圖 20示）係作為一用於將功率提供至致動器515之導管。致動器 515連接至致動器軸51〇。當致動器515為一步進馬達時，致 動器軸510與致動器515為一體。機械連桿介面545連接至致 動器軸510。此組態中，隨著致動器515使致動器軸51〇往上 移向針頭210，機械連桿介面545亦往上移向針頭210。本發 200824662 明的其他實施例中，機械連桿介面545及致動器軸51〇為單 一組件。易言之’一連接至致動器515之軸係包括身為單_ 總成之致動器轴51 〇及機械連桿介面545。 控制器305經由介面535連接至有限重覆使用總成介面 5連接器553。有限重覆使用總成553設置於與機械連桿介面 . 545相鄰之有限重覆使用總成殼體255的一頂表面上。利用 ^ 此方式，有限重覆使用總成介面連接器553及機械連桿介面 • 545兩者適可分別被連接於梢端介面連接器453及柱塞介面 420。 10 挂制器305及致動器515係由一介面（未圖示）所連接。此 介面（未圖示）可容許控制器305控制致動器515的操作。此 外，一位於功率源505與控制器305之間的介面（未圖示）可容 σ午控制305控制功率源505的插作。在此例中，控制哭305 可在功率源505身為可再充電式電池時控制功率源5〇5的充 15 電及放電。 • 控制器3〇5通常為能夠進行邏輯功能之一具有功率、輸 • 入及輸出銷針的積體電路。不同實施例中，控制器3〇5為一 目標式裝置控制器。在此例中，控制器3〇5進行目標在於一 諸如溫度控制裝置或功率供應器等特定裝置或組件之一特 2〇定控制功能。譬如，一溫度控制裝置控制器具有用於控制 一溫度控制裝置之基本機能。其他實施例中，控制器305為 一微處理器。在此例中，控制器3〇5可被程式化使其可運作 來控制裝置的不只一組件。其他案例中，控制器3〇5並非可 程式化微處理器，而是身為一構形為可控制用於進行不同 15 200824662 功能的不同組件之特定用途控制器。雖在第5圖中描繪為一 組件’控制！§3G5可由許多不同組件或積體電路製成。 梢端分段205適可對接於或附接至有限重覆使用總成 250。第5圖的實施例中，設置於柱塞415的一絲面上之柱 5塞介面420適可對接於接近有限重覆使用總成殼體255的一 頂表面之機械連桿介面545。此外，梢端介面連接器453適 可連接於有限重覆使用總成介面連接器553。當梢端分段 205利用此方式連接至有限重覆使用總成25〇時，致動器515 及致動器軸510適可驅動柱塞415往上朝向針頭21〇。此外， 1〇 一介面形成於控制器305與溫度控制裝置45〇之間。一信號 可經由介面535、有限重覆使用總成介面連接器553、梢端 介面連接器453、及介面530從控制器3〇5通至溫度控制裝置 450 〇 操作中，當梢端分段205連接至有限重覆使用總成25〇 15日守，控制器305控制致動器515的操作。當致動器515被致動 日寸，致動器軸510往上移向針頭21〇。轉而言之，對接於柱 塞介面420之機械連桿介面545係移動柱塞415往上朝向針 頭210。一設置於配送室405中之物質隨後經由針頭21〇被驅 出。 20 此外，控制器305控制溫度控制裴置450的操作。溫度 控制裝置450適可加熱及/或冷卻配送室殼體425及其内容 物。因為配送室殼體425至少具部份熱傳導性，加熱或冷卻 配送室殼體425將可加熱或冷卻位於配送室4〇5中的一物 質。溫度資訊可經由介面530、梢端介面連接器453、有限 16 200824662 重覆使用總成介面連接器553、及介面535從熱感測器460轉 移回到控制器305。可利用此溫度資訊來控制溫度控制裝置 450的操作。當溫度控制裝置45〇為一加熱器，控制器3〇5控 制被送到溫度控制裝置450之電流量。送到溫度控制裝置 5 450之電流愈大’則其變得愈熱。利用此方式，控制器305 可利用來自熱感測器460的資訊使用一回饋迴路以控制溫 度控制裝置450的操作。可使用諸如比例積分微分(ΡΠ))控 制器等任何適當類型的控制演算法來控制溫度控制裝置 450的操作。 10 第6圖為根據本發明的一實施例之一眼用醫療裝置的 一可拋棄式梢端分段之橫剖視圖。第6圖中，可拋棄式梢端 分段205包括殼體215、針頭210、柱塞415、柱塞介面420、 配送室405、配送室殼體425、總成555、溫度控制裝置450、 熱感測器460、選用性路厄430、梢端介面連接器451、452 15及453、及介面461、462及463。可拋棄式梢端分段205操作 作為一可拋棄式注射裝置。 第6圖的實施例中，柱塞415設置於配送室殼體425中。 配送室405被配送室殼體425及柱塞415包圍。柱塞415形成 與配送室殼體425内部表面之一流體密封。針頭210流體式 20 輕合至配送室405。利用此方式，一位於配送室405中之物 質可被柱塞415接觸且推出針頭210外。針頭210可被一選用 性路厄430固接至可拋棄式梢端分段205且可被永久性附 接。溫度控制裝置450設置於配送室殼體425上且至少部份 地圍繞配送室405。殼體215在可拋棄式梢端分段205上形成 17 200824662 一外皮。 本發明的不同實施例中，溫度控制裝置450為 一加熱及 或、"P衣ϊ /里度控制裝置45〇熱性接觸於配送室殼體 口此/皿度控制裝置450能約改變配送室秘中的物質 5 溫度。 - 細中，柱塞415包括一 G環。〇環密封抵住配送室殼 • 體425的—内部表面。利用此方式，維持-無菌密封因此防 • 止配送室405中物質的污染。柱塞415可由諸如玻璃、不錄 鋼、或聚合物等任何適當材料製成。〇環通常由橡膠或聚合 10物製成。亦可使用其他類型密封。譬如，柱塞415可包含一 沿柱塞415的-周邊設置之環狀環使得環狀環接觸配送室 _ 425内部表面。此環狀環可將柱塞密封抵住配送室425内部 表面。在此例中，環狀環可與柱塞415為一體，且柱塞415 可由橡膠或一聚合物製成。柱塞介面42〇可為任何適當的形 15狀。譬如，柱塞介面可如圖示實質呈碗形，或可實質呈扁 # 平、圓錐形、或球形。其亦可包括一唇或其他類似的特徵 結構。 梢端介面連接器451、452及453用來在梢端分段2〇5與 一有限重覆使用總成之間提供一連接。介面46丨將熱感測器 20 460連接至梢端介面連接器451。介面462將溫度控制裝置 450連接至梢端介面連接器452。介面463將總成555連接至 梢端介面連接器453。 總成5 5 5可包括數個不同組件的任何者。>實施例中， 總成555含有一當加熱按鈕被啟動時或可拋棄式梢端分段 18 200824662 205使用後被燒燬之熔絲。利用此方式，熔絲防止可拋棄式 梢端分段205重覆使用。另一實施例中，總成555包括一儲 存有關可抛棄式梢端分段205類型的資訊、劑量資訊、溫度 資訊、柱塞運動資訊、或用於識別可拋棄式梢端分段2〇5的 ^ 5 一特徵或可拋棄式梢端分段205操作方式之任何其他類型 — 資訊之$己憶體裝置。其他實施例中，總成205包括一硬配線 式記憶體裝置，如一NAND快閃1C，一RFID標籤，一可儲 存^料代表物之硬配線式電路，如並聯連接之一系列的溶 絲及電阻器或其他類型裝置。 10 一通常為藥物之將被輸送至眼中的物質係設置於配送 室405中。利用此方式，藥物被配送室殼體425内表面及柱 基415的一面所接觸。溫度控制裝置450係熱性接觸於配送 室殼體425。利用此方式，溫度控制裝置45〇適可控制配送 ’ 室405内容物的溫度。 15 本發明的不同實施例中，溫度控制裝置4 5 〇加熱_位於 ❿ 配达室40 5中之相變化合物。此相變化合物攜載一將被注射 • ㈣中之藥物…相變化合物在較低溫度處於固體或半固 體狀態而在較高溫度為較液體狀態。此物質可被温度控制 • 裝置45G加熱至-較液體狀態且注射至眼中在其中形成__ 20隨時間錢的大丸。同理，可使用_反_化合物。 凝膠化合物在較高溫度處於固體或半固體狀態而在較低、田 度為較液體狀態。此化合物可藉由溫度控制裝置45〇冷卻: 一較液體狀紅注射錄中在其巾形成-隨_侵餘的大 丸。因此’溫度控職置45G可為—用於加熱配送室奶中 19 200824662 的一物質之裝置或一用於冷卻配送室405中的一物質之裝 置（或兩者的一組合）。被輸送至眼中之後，一相變化合物或 反凝膠化合物係隨時間侵蝕而在一延長時間期間提供一數 S樂物°利用一相變化合物或反凝膠化合物係以較少注射 5提供較好的藥物劑量。 熱感測器460提供溫度資訊以輔助控制溫度控制裝置 450的操作。熱感測器460可設置為接近配送室殼體425及測 置接近配送室殼體425之一溫度。熱感測器460亦可設置為 熱性接觸於配送室殼體425，在該例中其測量配送室殼體 10 425的一溫度。其他實施例中，熱感測器46〇測量的溫度係 可與配送室405中的物質溫度相關聯。易言之，可使用配送 室殼體425的一溫度測量來計算位居配送室405中的物質溫 度。因為配送室殼體425及其他物質的熱性特徵為已知，且 溫度控制裝置450的溫度可被控制，以一指定時間期間施加 15溫度控制裝置將導致配送室405中物質溫度之一可計算變 化。熱感測器460可為可提供溫度資訊之一數量的不同裝置 之任何者。譬如，熱感測器46〇可為一熱電偶或一具有隨溫 度變化的電阻之電阻性裝置。 本發明的一實施例中，位於配送室4〇5中的物質係為一 20預先衣載至配送室内之樂物。在此例中，可拋棄式梢端分 丰又205適宜作為單次使用消耗性產品。此可拋棄式產品可以 一所裝設藥物劑量在一工廠組裝。 當一樂物預先裝載至配送室4〇5内時，可預先裝载一設 定數量的藥物。譬如，100微升的一藥物可被裝載至配送室 20 200824662 405内，且可配送最高達到100微升的任何數量。有關配送 至205中的樂物3:之資Λ及其他劑量資訊可儲存在總成555 中。在此例中，柱基415可移動一精密距離以將一精密劑量 的藥物從配送室405輸送經過針頭21〇、及進入一眼中。這 5 提供劑量化的彈性及組裝的容易度。 第7圖為根據本發明的一實施例之一用於眼用醫療裝 置之可拋棄式梢端分段的橫剖視圖。第7圖中，可拋棄式梢 端分段205包括殼體215、針頭210、柱塞415、柱塞介面420、 配送室405、配送室激體425、總成555、溫度控制裝置450、 10 熱感測器460、選用性路厄430、梢端介面連接器452及453、 介面462及463、及鎖機構471。 弟7圖的實施例具有如第6圖實施例的運作。第7圖的梢 端分段205之不同組件具有與第6圖類似組件相同之特徵及 貫質相同的操作方式。鎖機構471可用來將梢端分段205附 15接至一有限重覆使用總成。一位於一有限重覆使用總成上 之如鎖機構265的對接機構係附接至鎖機構471且將梢端分 段205固接至一有限重覆使用總成。In one embodiment consistent with the principles of the present invention, the present invention is a finite overlap use assembly having an actuator including one axis and a power source for providing a second rate to the actuation port, Control of the actuator control: - mechanical linkage interface, and - housing. The mechanical link interface is brought together to move the two shafts and has a mating surface on one end. The housing at least partially surrounds the force source control and the actuator. The limited repeat assembly can be attached to and removed from a disposable injection device. In another embodiment consistent with the principles of the present invention, the present invention is a finite overlap use assembly having an actuator including a shaft, a power source for equal force rate being provided to the actuator, Control for controlling the actuator 7 200824662, - mechanical linkage interface, a housing, and an indicator. The mechanical linkage shank is coupled to the actuator shaft and has a mating surface on the _ end. The housing at least partially surrounds the power source, controller, and actuator. The indicator is disposed on the housing and provides information regarding a state of the limited reuse assembly. The controller controls the operation of the actuator to cause the actuator to drive the actuator to deliver a dose of a substance to an eye. The above general description and the following detailed description are merely exemplary and are intended to be illustrative of the invention. The additional features and objects of the present invention are set forth and suggested by the following description and the present disclosure. BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in FIG 1 is a perspective view of a prior art syringe; FIG. 2 is a diagram of an ophthalmic medical device including a disposable tip 15 segment and a finite overlap assembly in accordance with an embodiment of the present invention; Figure 3 is another embodiment of a finite overlap assembly in accordance with the principles of the present invention; and Figure 4 is a cross-sectional view of another embodiment of a finite overlap assembly in accordance with the principles of the present invention; 20 is a cross-sectional view of a disposable tip segment and a finite overlap assembly in accordance with an embodiment of the present invention; FIG. 6 is a view of one embodiment of the present invention for use in an eye Cross-sectional view of a disposable tip segment of a medical device; Figure 7 is a cross-sectional view of a disposable tip segment for an ophthalmic medical 8 200824662 device in accordance with an embodiment of the present invention; 8 is a cross-sectional view of a disposable tip end and a partial view of a finite overlap assembly according to an embodiment of the present invention. FIG. 9A is an illustration for an ophthalmic medical treatment according to an embodiment of the present invention. 5 cross-sectional view of the disposable tip segment of the garment ; An end view of an embodiment of a first graph of FIG. 9A 9B; a second 1〇Α-1_ is a schematic diagram according to an embodiment of the present invention, four different circuits may be included. Figure 11 is a cross-sectional view of a finite overlap assembly according to one embodiment of the present invention, according to the present invention - a limited weight (4) into a view, and a twelfth view; EMBODIMENT - EMBODIMENT A cross-sectional view of a finite overlap assembly; 15 14th and 15th are cross-sectional views of a two-in-one assembly according to the present invention, and Figure 16 is a finite overlap in accordance with the principles of the present invention. A cross-sectional view of the assembly, the tip segment, and a charging substrate; FIGS. 17A and 17B are flow diagrams of a method for injecting a substance 20 into an eye in accordance with one or more principles of the present invention; One of the principles of the present invention relates to a method of injecting a substance into an eye; Figure 19 is a flow chart showing a method of injecting a substance into an eye in accordance with one of the principles of the present invention; 9 200824662 Figure 20 is based on One of the principles of the present invention relates to a flow chart of a method of injecting a substance into an eye. [Embodiment 3] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Reference is now made in detail to the exemplary embodiments of the invention Where possible, the same reference numbers will be used in the drawings to represent the same or similar parts. Figure 2 is a diagram of an ophthalmic medical device including a disposable tip segment and a finite overlap assembly in accordance with an embodiment of the present invention. In Fig. 2, the medical device includes a tip end segment 205 and a limited repeat use assembly 250. The tip segment 2〇5 includes a needle 210, a housing 215, and a selective light 275. The finite overlap assembly 250 includes a housing 255, a switch 270, a lock mechanism 265, and a threaded portion 260. The tip section 205 can be connected to and removed from a total of 15 to 250 from limited reuse. In this embodiment, the tip section 205 has a threaded portion on a φ inner surface of the housing 215 that is threaded onto the threaded portion 260 of the finite overlap assembly 250'. In addition, the lock mechanism 265 secures the tip end section 215 to the limited repeat use assembly 250. The lock mechanism 265 can be in the form of a button, a slide switch, or a cantilevered mechanism. Other mechanisms for attaching the tip segments 205 to the finite overlap assembly 25, such as those comprising structural features that are butted to each other, are generally known in the art and are within the scope of the present invention. The needle 210 is adapted to deliver a substance such as a drug to one eye. Needle 210 can be of any conventional known configuration. Needle 2 (7) is preferably designed such that its thermal characteristics of 200824662 contribute to a particular drug delivery application. For example, when the drug is to be delivered - the drug 210 may be of relatively short (several mm) length (for sexual use) to facilitate proper delivery of the drug. Switch 270 is adapted to provide an input to the system. For example, switch 5 270 can be used to activate (10), turn on or turn on the temperature control position. Other systems, buttons, or user-guided control wheels are generally known and may be used with limited reuse assembly 250 and/or tip segments 2〇5. _ When tip segment 205 When ready for use, the optional light 275 illuminates. The optional light 275 can protrude from the housing 215 or it can be enclosed within the 10 housing. In this example, the optional light 275 can be via the housing 215. A colorless portion is seen. In other embodiments, the optional light 275 can be replaced by an indicator such as a liquid crystal display, a segmented display, or other means for indicating the status or condition of the disposable tip segment 205. For example, the optional light 275 can illuminate the pulse to indicate other conditions, such as, but not limited to, a 15 system error, a fully charged battery, a undercharged battery or tip segment ^ 205, and a finite overlap assembly 250 The wrong connection. Although shown on the tip segment 205, an optional light 275 or an additional indicator can be placed on the finite overlap assembly 250. w Figure 3 is a finite overlap in accordance with the principles of the present invention. Use assembly In another embodiment, the limited repetitive use assembly 250 includes a button 308, a display 320, and a housing 330. The disposable tip segment 205 is attached to the end 340 of the limited repetitive use assembly 250. Button 308 is actuated to provide an input to the system. Like switch 270, button 308 can activate a temperature control device or initiate actuation of a plunger. Display 320 is a liquid crystal display, segmented display 12 200824662, or Other means for indicating the state or condition of the disposable tip segment 205 or the finite overlap assembly 250. Figure 4 is a cross-sectional view of another embodiment of the finite overlap assembly in accordance with the principles of the present invention. In Fig. 4, power source 5〇5, interface 517, actuator 5, and actuator shaft 510 are disposed in housing 255. The top portion of housing 255 has a threaded portion 260. Locking mechanism 265, switch 270, press Cui 308, and indicators 306, 307 are all disposed on the housing 255. The power source 505 is typically a rechargeable battery such as a lithium ion battery, but other types of batteries can be used. Any other type of power cell 10 A power source 505 is suitable. Power source 505 provides power to the system, and more particularly to actuator 515. Power source 505 also provides power to a tip segment that is coupled to limited reuse assembly 250. In this example, power source 505 can provide power to a temperature control device (not shown) disposed in the tip end. Alternatively, power source 505 can be configured via a door or other similar feature 15 (not shown) The interface 517 is typically an electrical conductor that allows power to flow from the power source 505 to the actuator 515. Other interfaces, such as interface 517, may also be present to provide % rate to other portions of the system. . The actuator shaft 510 is coupled to and driven by the actuator 515. Actuator 515 20 is typically a stepper motor or other type of motor capable of moving actuator shaft 510 a precise distance. In one embodiment, the actuator shaft 510 is coupled to a tip end segment via a mechanical linkage to deliver a drug to an eye. In this example, actuator 515 is a stepper motor that can move shaft 510 exactly to deliver an exact amount of drug into the eye. Actuator 515 is secured to an interior surface of housing 255, for example, by a tab for engaging the outer surface of actuator 12 200824662. In other embodiments, actuator 515 is a linear actuator or linear actuator. In this example, the actuator 515 can be a spring or spring-driven mechanism, a geared DC 5 motor having a rotary sensor coupled to a linear actuator, or a coupled to a linear sensor A linear actuator DC motor, or a linear stepper motor. Other types of motors, such as rotating permanent magnet motors, may also be used with actuator 515. The lock mechanism 265, the switch 270, and the button 308 are all disposed on the housing 255 so that they can be manipulated by hand. Similarly, the indicators 306, 307 are disposed on the housing 255 so that they can be viewed. Lock mechanism 265, switch 270, button 308, and indicators 306, 307 are also coupled to a controller (not shown) via an interface (not shown) disposed in housing 255. Figure 5 is a cross-sectional view of a disposable tip segment and a finite overlap assembly in accordance with a consistent embodiment of the present invention. Figure 5 shows how the tip segment 15 205 forms an interface with the finite overlap assembly 250. In the embodiment of Figure 5, the tip section 205 includes an assembly 555, a plunger interface 420, a plunger 415, a dispensing chamber housing 425, a tip segment housing 215, a temperature control device 450, a thermal sensor. 460, needle 210, delivery chamber 405, interface 530, and tip interface connector 453. The finite overlap assembly 250 includes a mechanical linkage interface 545, 20 actuator shaft 510, an actuator 515, a power source 505, a controller 305, a finite overlap assembly housing 255, an interface 535, and a finite weight The assembly interface connector 553 is overwritten. In the tip section 205, a plunger interface 420 is disposed on one end of the plunger 415. The other end of the plunger 415 forms one end of the delivery chamber 405. The plunger 415 is adapted to slide in the delivery chamber 405 13 200824662. The outer surface of the plunger 415 is fluidly sealed to the inner surface of the dispensing chamber housing 425. The dispensing chamber housing 425 surrounds the dispensing chamber 4〇5. In general, the delivery chamber housing 425 has a cylindrical shape. Therefore, the distribution room also has a cylindrical shape. In the tip section 205, the assembly 555 includes any number of components, as described below. The needle 210 is fluidly coupled to the dispensing chamber 4〇5. In this case, a substance enclosed in the dispensing chamber 405 can pass through the needle 21 and into one eye. The temperature control device 450 at least partially surrounds the dispensing chamber housing 425. In this example, the temperature control device 450 is adapted to heat and/or cool any of the contents of the dispensing chamber housings 425 and 10 that are enclosed in the dispensing chamber 405. Interface 530 connects temperature control device 450 to tip interface connector 453. The components of the tip section 205, including the dispensing chamber housing 425, the temperature control device 450, and the plunger 415 are at least partially surrounded by the tip segment housing 215. In one embodiment consistent with the principles of the present invention, the plunger 415 is sealed 15 to the interior surface of the dispensing chamber housing 425. This seal prevents contamination of any material trapped in the dispensing chamber 405. For medical use, this seal is desirable. This seal can be placed at any point on the plunger 415 or the delivery chamber housing 425. In the limited reuse assembly 250, the power source 505 provides power to the actuator 515. An interface between the power source 505 and the actuator 515 (not shown in Figure 20) serves as a conduit for providing power to the actuator 515. Actuator 515 is coupled to actuator shaft 51A. When the actuator 515 is a stepping motor, the actuator shaft 510 is integral with the actuator 515. Mechanical linkage interface 545 is coupled to actuator shaft 510. In this configuration, as the actuator 515 moves the actuator shaft 51 up toward the needle 210, the mechanical linkage interface 545 also moves up the needle 210. In other embodiments of the present invention, the mechanical linkage interface 545 and the actuator shaft 51 are a single assembly. It is to be understood that the shaft that is coupled to the actuator 515 includes an actuator shaft 51 and a mechanical linkage interface 545 that are a single assembly. Controller 305 is coupled via interface 535 to a finite overlap use assembly interface 5 connector 553. The finite overlap assembly 553 is disposed on a top surface of the assembly housing 255 adjacent to the mechanical linkage interface 545. Using this approach, the finite overlap assembly interface connector 553 and the mechanical linkage interface 545 are suitably coupled to the tip interface connector 453 and the plunger interface 420, respectively. The hanger 305 and the actuator 515 are connected by an interface (not shown). This interface (not shown) may allow controller 305 to control the operation of actuator 515. In addition, an interface (not shown) between the power source 505 and the controller 305 can accommodate the interpolation of the power source 505. In this example, the control cry 305 can control the charging and discharging of the power source 5〇5 when the power source 505 is a rechargeable battery. • Controller 3〇5 is usually an integrated circuit that has power, input and output pins for one of the logic functions. In various embodiments, controller 3〇5 is a target device controller. In this example, the controller 3〇5 performs a control function that is targeted at a specific device or component such as a temperature control device or a power supply. For example, a temperature control device controller has basic functions for controlling a temperature control device. In other embodiments, controller 305 is a microprocessor. In this example, controller 3〇5 can be programmed to operate to control more than one component of the device. In other cases, controller 3〇5 is not a programmable microprocessor, but rather a special purpose controller that is configured to control different components for different 15200824662 functions. Although depicted in Figure 5 as a component 'control! §3G5 can be made from many different components or integrated circuits. The tip section 205 is adapted to be docked or attached to the limited repeat use assembly 250. In the embodiment of Fig. 5, the post 5 plug interface 420 disposed on a face of the plunger 415 is adapted to abut the mechanical link interface 545 of a top surface of the finite overlap assembly assembly housing 255. In addition, the tip interface connector 453 is adapted to be coupled to a finite overlap assembly interface connector 553. When the tip section 205 is coupled to the finite overlap assembly 25 利用 in this manner, the actuator 515 and the actuator shaft 510 are adapted to drive the plunger 415 upwardly toward the needle 21 〇. Further, an interface is formed between the controller 305 and the temperature control device 45A. A signal can be passed from the controller 3〇5 to the temperature control device 450 via the interface 535, the finite overlap assembly interface connector 553, the tip interface connector 453, and the interface 530, when the tip segment 205 The controller 305 controls the operation of the actuator 515 by connecting to the finite overlap use assembly. When the actuator 515 is actuated, the actuator shaft 510 is moved up to the needle 21A. In other words, the mechanical linkage interface 545 that is docked to the plunger interface 420 moves the plunger 415 upwardly toward the needle 210. A substance disposed in the dispensing chamber 405 is then ejected via the needle 21 〇. Further, the controller 305 controls the operation of the temperature control device 450. The temperature control device 450 is adapted to heat and/or cool the delivery chamber housing 425 and its contents. Because the dispensing chamber housing 425 is at least partially thermally conductive, heating or cooling the dispensing chamber housing 425 will heat or cool a material located in the dispensing chamber 4〇5. Temperature information can be transferred from thermal sensor 460 back to controller 305 via interface 530, tip interface connector 453, finite 16 200824662, overlay assembly interface connector 553, and interface 535. This temperature information can be utilized to control the operation of temperature control device 450. When the temperature control unit 45 is a heater, the controller 3〇5 controls the amount of current sent to the temperature control unit 450. The greater the current delivered to the temperature control device 5 450, the hotter it becomes. In this manner, controller 305 can utilize a feedback loop from the information from thermal sensor 460 to control the operation of temperature control device 450. Any suitable type of control algorithm, such as a proportional integral derivative (ΡΠ) controller, can be used to control the operation of temperature control device 450. 10 is a cross-sectional view of a disposable tip segment of an ophthalmic medical device in accordance with an embodiment of the present invention. In Fig. 6, the disposable tip segment 205 includes a housing 215, a needle 210, a plunger 415, a plunger interface 420, a dispensing chamber 405, a dispensing chamber housing 425, an assembly 555, a temperature control device 450, and heat. Sensor 460, optional luer 430, tip interface connectors 451, 452 15 and 453, and interfaces 461, 462 and 463. The disposable tip segment 205 operates as a disposable injection device. In the embodiment of Fig. 6, the plunger 415 is disposed in the delivery chamber housing 425. The delivery chamber 405 is surrounded by the delivery chamber housing 425 and the plunger 415. The plunger 415 is formed in fluid tight contact with one of the interior surfaces of the dispensing chamber housing 425. The needle 210 fluid 20 is lightly coupled to the dispensing chamber 405. In this manner, a substance located in the dispensing chamber 405 can be contacted by the plunger 415 and pushed out of the needle 210. The needle 210 can be secured to the disposable tip segment 205 by an optional luer 430 and can be permanently attached. The temperature control device 450 is disposed on the dispensing chamber housing 425 and at least partially surrounds the dispensing chamber 405. The housing 215 forms a 2008 200824662 outer skin on the disposable tip segment 205. In various embodiments of the present invention, the temperature control device 450 is a heating and/or "P"/Rid control device 45 is in thermal contact with the delivery chamber housing port. The / degree control device 450 can change the delivery chamber. The substance 5 temperature in the secret. - In the middle, the plunger 415 includes a G ring. The ankle ring seals against the interior of the delivery chamber housing 425. In this way, the maintenance-sterile seal thus prevents contamination of the contents of the dispensing chamber 405. The plunger 415 can be made of any suitable material such as glass, stainless steel, or polymer. The anthracene ring is usually made of rubber or polymerized material. Other types of seals can also be used. For example, the plunger 415 can include an annular ring disposed along the periphery of the plunger 415 such that the annular ring contacts the interior surface of the dispensing chamber 425. This annular ring seals the plunger against the interior surface of the dispensing chamber 425. In this case, the annular ring may be integral with the plunger 415, and the plunger 415 may be made of rubber or a polymer. The plunger interface 42A can be any suitable shape. For example, the plunger interface can be substantially bowl-shaped as shown, or can be substantially flat, flat, conical, or spherical. It may also include a lip or other similar feature. Tip interface connectors 451, 452, and 453 are used to provide a connection between the tip end segment 2〇5 and a limited repetitive use assembly. Interface 46A connects thermal sensor 20 460 to tip interface connector 451. Interface 462 connects temperature control device 450 to tip interface connector 452. Interface 463 connects assembly 555 to tip interface connector 453. Assembly 555 can include any of a number of different components. > In an embodiment, assembly 555 includes a fuse that is burned when the heated button is activated or the disposable tip segment 18 200824662 205 is used. In this manner, the fuse prevents the disposable tip segment 205 from being used repeatedly. In another embodiment, assembly 555 includes information relating to the type of disposable tip segment 205, dose information, temperature information, plunger motion information, or for identifying disposable tip segments 2〇5 ^ 5 A feature or any other type of disposable tip segment 205 operation - the $$ memory device of the information. In other embodiments, the assembly 205 includes a hard-wired memory device, such as a NAND flash 1C, an RFID tag, a hard-wired circuit that can store a representative of the material, such as a series of filaments connected in parallel. Resistor or other type of device. A substance, usually a drug to be delivered to the eye, is placed in the dispensing chamber 405. In this manner, the drug is contacted by the inner surface of the delivery chamber housing 425 and one side of the column base 415. Temperature control device 450 is in thermal contact with dispensing chamber housing 425. In this manner, the temperature control device 45 is adapted to control the temperature of the contents of the dispensing chamber 405. In a different embodiment of the invention, the temperature control device 45 〇 heats the phase change compound located in the ❿ distribution chamber 40 5 . This phase change compound carries a drug that will be injected. (4) The phase change compound is in a solid or semi-solid state at a lower temperature and a liquid state at a higher temperature. This material can be temperature controlled. • Device 45G is heated to a liquid state and injected into the eye where the pellets of __20 are formed over time. For the same reason, _anti-compounds can be used. The gel compound is in a solid or semi-solid state at a higher temperature and a liquid state at a lower, field. This compound can be cooled by a temperature control device 45: a more liquid-like red injection recorded in its towel-formed-with-invading pellet. Thus, the temperature control unit 45G can be a device for heating a dispensing chamber milk 19 200824662 or a device for cooling a substance in the dispensing chamber 405 (or a combination of the two). After being delivered to the eye, a phase change compound or anti-gel compound provides corrosion over time and provides a number of S music during an extended period of time using a phase change compound or an inverse gel compound to provide less injection 5 Good drug dosage. Thermal sensor 460 provides temperature information to assist in controlling the operation of temperature control device 450. Thermal sensor 460 can be disposed proximate to dispensing chamber housing 425 and measuring a temperature near one of dispensing chamber housings 425. Thermal sensor 460 can also be configured to be in thermal contact with dispensing chamber housing 425, which in this example measures a temperature of dispensing chamber housing 10 425. In other embodiments, the temperature measured by the thermal sensor 46 can be correlated to the temperature of the substance in the delivery chamber 405. In other words, a temperature measurement of the dispensing chamber housing 425 can be used to calculate the temperature of the material in the dispensing chamber 405. Because the thermal characteristics of the dispensing chamber housing 425 and other materials are known, and the temperature of the temperature control device 450 can be controlled, applying a temperature control device during a specified time period will result in a changeable calculation of one of the material temperatures in the dispensing chamber 405. . Thermal sensor 460 can be any of a number of different devices that can provide one of the temperature information. For example, thermal sensor 46A can be a thermocouple or a resistive device having a temperature varying resistance. In one embodiment of the invention, the material located in the dispensing chamber 4〇5 is a piece of music that is pre-loaded into the dispensing chamber. In this case, the disposable tip divider 205 is suitable as a single use consumable product. This disposable product can be assembled in a factory with a dose of drug installed. When a piece of music is preloaded into the delivery chamber 4〇5, a set amount of the medicine can be preloaded. For example, 100 microliters of a drug can be loaded into the delivery room 20 200824662 405 and can be dispensed in any amount up to 100 microliters. Information about the distribution of music to the 205 and other dose information can be stored in assembly 555. In this example, the post 415 can be moved a precise distance to deliver a precise dose of medication from the dispensing chamber 405 through the needle 21 and into one eye. This 5 provides dose flexibility and ease of assembly. Figure 7 is a cross-sectional view of a disposable tip segment for an ophthalmic medical device in accordance with one embodiment of the present invention. In Fig. 7, the disposable tip segment 205 includes a housing 215, a needle 210, a plunger 415, a plunger interface 420, a dispensing chamber 405, a dispensing chamber 425, an assembly 555, temperature control devices 450, 10 Thermal sensor 460, optional luer 430, tip interface connectors 452 and 453, interfaces 462 and 463, and lock mechanism 471. The embodiment of Figure 7 has the operation of the embodiment of Figure 6. The different components of the tip segment 205 of Figure 7 have the same features and similar quality of operation as the components of Figure 6. A lock mechanism 471 can be used to attach the tip end segment 205 to a limited repetitive use assembly. A docking mechanism, such as lock mechanism 265, on a limited repetitive use assembly is attached to lock mechanism 471 and secures tip section 205 to a limited reuse assembly.

第8圖為根據本發明的一實施例之一有限重覆使用總 成的部分圖及一可拋棄式梢端分段的橫剖視圖。第7圖中， 20可拋棄式梢端分段205包括殼體215、針頭210、柱塞415、 柱塞介面420、配送室405、配送室殼體425、RFID標籤1110、 溫度控制裝置450、梢端介面連接器452、及介面462。一有 限重覆使用總成的部分圖係描繪機械連桿介面545、致動器 軸510、介面535、有限重覆使用總成介面連接器552、RFID 21 200824662 讀取器1120、及RFID介面1130。 第8圖的實施例具有如第6及7圖實施例的運作。第8圖 .的梢端分段20 5之不同組件具有與第6及7圖的類似組件相 同之特徵及實質相同操作方式。然而，第8圖的實施例係使 5 用一RFID系統而非一配線式總成555以儲存及轉移資訊。 RFID讀取器1120設置為接近與機械連桿介面545相鄰之一 有限重覆使用總成頂部。RFID標籤設置於梢端分段205底 部。RFID讀取器1120設計為可自RFID標籤1110讀取資訊。 RFID介面1130連接至控制器3〇5(未圖示）。 10 RFID標籤1110係構形為可容納有第5至7圖實施例中總 成555所可容納者之相同類型資訊。利用此方式，RFID標籤 1110為另一類型記憶體。然而，如時常所習知，RFID標籤 1110不需要對於RFID讀取器1120之一配線式連接。利用此 方式，梢端分段205(RFID標籤1110)與一有限重覆使用總成 15 (RFID讀取器1120)之間可建立一無線式連接。 一類型的RFID系統亦即一被動rFID系統中，RFID^ 籤1110不具有功率供應器。取而代之，被動^^仍標籤對其 功率仰賴RFID讀取器1120產生的電磁場。RFID讀取器112〇 所產生及RFID讀取器天線（未圖示）所發射之電磁場係在 20 RFID標籤1110中誘發一小電流。此小電流可容許RFID標籤 iiio操作。此被動系統中，rFID標籤設計成可自RFID讀取 器1120發射的電磁場收集功率且發送一由RFm讀取器ιΐ2〇 接收之往外信號。 操作中，RFID讀取器天線(未圖示)發送一*RFm讀取 22 200824662 器1120產生之信號。RFID標籤天線（未圖示）接收此信號且 在RFID標籤111 〇中誘發一小電流。此小電流對sRFID標籤 1110供應功率。RFID標籤1110隨後可經由其RFID標籤天線 發送一信號至RFID讀取器天線及RFID讀取器1120本身。利 5用此方式，RFH)標籤1110及RFID讀取器1120可在一射頻連 結上彼此導通。RFID 1110經由RFID標籤天線發送諸如劑量 資訊或梢端分段資訊等資訊至RFID讀取器1120。此資訊被 RFID讀取器1120接收。利用此方式，資訊可從梢端分段2〇5 轉移至有限重覆使用總成。RFID讀取器120可以一類似方式 10將資訊發送至RFID標籤1110。譬如，rfid讀取器1120可在 RFID頌取1120發射的射頻信號上發送諸如劑量資訊等資 訊。RFID標籤1120接收此含有該資訊之射頻信號。处1〇標 籤1110隨後可儲存此資訊。 雖然第8圖的實施例描述為具有—RFn)系統，可使用 15任何其他類型的無線系統在一有限重覆使用總成250與梢 端分段205之間轉移資訊。譬如，可使用一藍芽協定在一有 限重覆使用總成250與梢端分段205之間建立一導通連結。 資訊隨後可在此導通連結上被轉移於一有限重覆使用總成 250與一梢端分段205之間。用來轉移資訊之其他實施例係 20包括一紅外線協定、802.11、火線(fire wire)、或其他無線 協定。 一實施例中，RFID標籤1110 (或總成555)含有劑量資 訊。有關對於配送室405所含藥物的適當藥物劑量之資訊係 可被包含在RFID標籤1110 (或總成555)上。在此例中，控制 23 200824662 器305可自RFID標籤1110 (或總成555)讀取劑量資訊且以適 合輸送適當劑量的方式來操作致動器515。譬如，配送室405 内可包含100微升。RFID標籤1110 (或總成555)上可能儲存 有陳述將20微升劑量輸送至眼中之資訊。在此例中，控制 5器305自RFID標籤1110 (或總成555)讀取劑量資訊(應將20 微升輸送至眼中）。控制器305隨後可操作致動器515以輸送 20微升劑量。控制器3〇5可造成致動器515將致動器軸510及 機械連桿介面545移動一與20微升劑量相關之設定距離。在 此例中，柱塞415移動此設定距離故只有2〇微升藥物自針頭 1 〇 210驅出及進入·—眼中。 與本發明原理呈現一致之另一實施例中，控制器3〇5 可計异一柱塞415所必須移動以輸送所想要劑量之距離。譬 如，若藉由控制器305自RFID標籤1110(或總成555)讀取對 應於20微升樂物劑量之劑量資訊，則控制器3〇5可使用此資 15訊來計算柱塞415必須移動之一適當距離。因為配送室405 的谷積及裝載於配送室405中之一藥物容積為已知，可藉由 控制器305來計算柱塞415必須移動以輸送該所想要劑量之 -距離。當配送室405具有-圓柱形時，可利用圓柱的橫剖 面積(及-IS形的面積)乘以配送室高度來計算配送室的容 積。可使用此簡單數學式來計算配送室4〇5總容積。因為配 送室405的橫剖面積對於任何給定應用皆為㈣，可對於任 何劑量量計算出對應於柱塞415移行距離之高度。 譬如，假設1〇〇微升藥物被裝载至配送室4〇5内且配送 室405的橫剖面積為十。當配送室4〇5為一圓柱形狀，該圓 24 200824662 柱的高度亦為10。為了輸送對應於配送室405總容積的20% 之20微升劑量，需將柱塞415往上移向針頭210—段身為二 之距離。易言之，一20微升劑量對應於配送室405總容積的 20%。在此例中，柱塞415應往上移向針頭210—段等於配 5送室405總高度的20%之距離。控制器305隨後可控制致動 ‘ 器515使得致動器軸510將柱塞415往上移動配送室405總高 ^ 度的20%之一距離。 • 此外，控制器305可讀取有關柱塞415應被移動藉以適 §地輸送樂物劑ΐ的速率之資訊。在此例中，控制器305 10自RFID標籤111〇(或總成555)讀取有關藥物輸送速率之資 訊且使用該資訊來操作致動器515以該速率來驅動柱塞 。 415。柱塞415移動的速率可為固定或可變。部分應用中， 可能想要比其他應用中更快地移動柱塞415。譬如，當配送 至405中所§樂物為應在注射至眼中前加熱之藥物時，可能 15希望以使經加熱藥物不會冷卻及堵塞針頭210的速率來驅 • 動柱塞415。其他應用中，可能希望緩慢移動柱塞415藉以 改良配送室405中的一藥物輸送。 RFID 111〇(或總成555)亦可包括有關一藥物輸送之任 何其他類型資訊。譬如，RFID標籤111〇(或總成555)可包括 20有關配送室405中所含藥物類型、該藥物的不同特徵、或一 適當劑里或该樂物的一適當輸送的其他特徵之資訊。此 外，RFID標籤111〇(或總成555)可含有安全性資訊、有關梢 端分段205適當操作之資訊、或有關梢端分段或有限重覆使 用總成之任何其他資訊。 25 200824662 與本發明原理呈現一致之另一實施例中，可由施用藥 物的醫療專業人員選擇一劑量。在此例中，一設置於有限 重覆使用總成250或梢端分段2〇5上之輸入裝置（未圖示)可 使醫師能夠選擇所想要的藥物劑量。在此例中，控制器3〇5 5接收所想要的藥物劑量且操作致動器515以將柱塞415移動 所需要的距離以輸送所想要的劑量。可簡單地藉由添加一 額外輸入裝置來實行此使用者可選擇式劑量方案。 可能希望在RFID標籤111 〇(或總成555)上包括劑量資 訊藉以車父不易發生劑量化錯誤。在此例中，數個不同藥物 10輸送梢端分段205可能在工廠製造及裝載有一藥物。劑量資 訊亦可在工廠被裝載於RFID標籤111〇(或總成555)上。在此 例中，可製造及運送各在配送室405内含有相同藥物量但在 RFID標籤111〇(或總成555)上儲存有不同劑量資訊之數個 不同梢端分段。醫師隨後可訂購在rFID標籤111〇(或總成 15 555)上具有所需要劑量資訊之梢端分段205。包裝可被清楚 地標示以識別劑量資訊使得適當劑量施用至一患者。 第9A圖為根據本發明的一實施例之一用於眼用醫療裝 置的可拋棄式梢端分段之橫剖視圖。第9圖中，可拋棄式梢 端分段205包括殼體215、針頭210、柱塞415、柱塞軸417、 2〇柱塞介面420、配送室405、配送室殼體425、總成555、溫 度控制裝置450、熱感測器460、選用性路厄430、梢端介面 連接器452及453、介面462及463、及籤片472及473。 第9圖的梢端分段205之不同組件具有與第5至8圖的類 似組件相同之特徵及與相同的操作方式。第9圖的實施例包 26 200824662 括兩個驗接合-有限域使_射的槽之籤片472及 473。這兩籤片472及473***槽中之後，梢端總成2〇5旋轉 將其鎖固在-有限重覆使用總成上的定位中。兩鐵片Μ及 473可此為不同形狀或尺寸藉以在梢端分段2〇5與有限重覆 5使用總成之間提供-適當介面。當兩鐵片仍及仍具有不 同形狀或尺寸時，則梢端分段4〇5只以一定向配合於一有限 重復使用總成上。本發明的其他實施例中，不同形狀或尺 寸的籤片可在不同有限重覆使用總成上配合使用不同形狀 或尺寸的槽。利用此方式，一數量的不同有限重覆使用總 10成可製有不同形狀或尺寸的槽以容納具有互補形狀或尺寸 籤片之梢端分段205。 此外，第9圖的實施例包括一連接至柱塞4i5之柱塞軸 417。此實施例中，柱塞415可被重疊模製於柱塞軸417上。 柱基軸417概王圓柱形狀且具有比其遠及近端呈更小直徑 15之中間直徑。柱塞介面420身為位於柱塞軸417近端上之一 表面。柱塞軸417通常由一諸如不銹鋼等剛性材料製造。柱 基415由橡勝或k合物材料製成。本發明的另一實施例中， 柱塞軸417的遠端具有一可供柱塞415施加其上之唇。柱塞 415可被壓入配合至柱塞軸417上且被柱塞軸417遠端上的 20 一唇扣持於定位。這可容許更容易作組裝。若不將柱塞415 重疊模製於一軸上，柱塞415可製成為一分離部份且被推押 至柱塞軸417遠端上。柱塞介面420可具有任何適當形狀。 第9B圖為第9A圖的梢端分段之端視圖。圖描繪最遠 離針頭210之梢端分段205端。此端與一有限重覆使用總成 27 200824662 形成介面。描緣殼體215、柱塞介面、梢端介面連接器 451、452、453、454、455及456、籤片 472及473、及對準 槽 481。 第则，的實施例中，柱塞介面的_端並非完全圓 5形。其具有-設計成對準於一具有一類似橫剖面形狀的機 械連桿介面之扁平部分。此選用性特徵結構設計成可容許 一梢端分段及一有限重覆使用總成作適當對準。本發明的 其他實施例中，柱塞介面420—端的橫剖視圖為圓形。 弟9B圖的貫施例亦包括一選用性對準槽以辅助一 10梢端分段適當地對準於一有限重覆使用總成。對準槽481與 一有限重覆使用總成上之一對準銷（第^圖顯示為581)形成 介面。本發明的另一實施例中，籤片472及473具有不同尺 寸。或者’戴片472及473可具有不同形狀。兩鐵片472及473 亦藉由與第11圖的槽572及573形成介面來輔助一梢端分段 對準於一有限重覆使用總成。 與本發明原理呈現一致之一實施例中，一梢端分段放 置在一有限重覆使用總成上以使籤片472及473***槽572 及5 7 3内。梢端分段隨後相對於有限重覆使用總成旋轉使得 籤片472及473被扣持在槽572及573中。對準銷581及對準槽 20 481隨後被適當地對準。 連接器451、452、453、454、455及456將一梢端分段 電性連結至一有限重覆使用總成。連接器451、452、453、 454、455及456在一有限重覆使用總成上分別與類似連接器 551、552、553、554、557及556形成介面（如第11圖所示）。 28 200824662 這些連接器提供一供信號穿過一梢端分段與一有限重覆使 用總成間之路徑。 弟10A-10D圖為可被包括在本發明實施例中之四個不 同電路的示意圖。第10A圖顯示用於溫度控制裝置450之許 5多不同組態的一者。第10A圖中，溫度控制裝置450連接至 連接器452及455。功率及/或控制信號經由連接器452及455 被提供至溫度控制裝置450。 第10B圖顯示用於熱感測器460之許多組態的一者。第 10B圖中，熱感測器460連接至連接器451及454。經由連接 10器451及454自熱感測器460接收信號。 第10C圖顯示用於一熔絲ion之許多不同組態的一 者。熔絲1011可被包含在總成555内或可如第l〇C圖所示實 行。第10C圖中，熔絲1〇11被連接於連接器453及456之間。 此實施例中，熔絲1011用來確保梢端總成身為單次使用裝 I5置。當加熱按鈕被啟動時或可拋棄式梢端分段2〇5使用之後 熔絲1011被燒燬。如上述，一有限重覆使用總成中的一控 制器係偵測經連接梢端分段何時已被使用且導引一增大電 流穿過熔絲loii因此燒燬溶絲。當溶絲ion被燒燦時，梢 端分段不再可操作而必須棄置。 20 第1圖顯示用於總成555之許多組態的一者。第i〇d 圖中，總成555連接至連接器453及456。功率及/或控制信 號經由連接器453及456被提供至總成555。 可實行連接器451、452、453、454、4M及456的許多 其他組悲。譬如，雖顯示六個連接器，可實行任何數量的 29 200824662 連接器。亚且’可在一梢端分段中包含不同電路的任何組 合。 、第=圖為根據本發明原理之-有限重覆使用總成的端 視圖。第11圖所示的有限重覆使用總成之端係與第9B圖所 示的梢成之端形成介面。弟11圖描繪的有限重覆使用 總成之端視圖顯示殼體255、機械連桿介面545、有限重覆 使用總成介面連接器55卜552、553、554、557及556、槽 572及573、及對準銷581。 第Η圖的實施例中，機械連桿介面545的一端並非完全 10圓形。其具有_設計成可對準於一具有類似橫剖面形狀的 柱塞介面之扁平部分。此選用性特徵結構設計成可容許一 梢端分段及一有限重覆使用總成適當對準。本發明的其他 貫施例中，機械連桿介面545的一端之橫剖視圖為圓形。 第11圖的實施例亦包括一選用性對準槽581以辅助一 15梢端分段適當對準於一有限重覆使用總成。對準銷581與一 梢端分段上之一對準槽（第9Β圖所示的481)形成介面。本發 明的其他實施例中，槽572及573具有不同尺寸。或者，槽 572及573可具有不同形狀。兩槽572及573亦藉由與第9B圖 所示之梢端分段的籤片472及473形成介面來辅助一梢端分 20段對準於一有限重覆使用總成。 連接器551、552、553、554、.557及556將一梢端分段 電性連結至一有限重覆使用總成。連接器551、552、553、 554、557及556與；一梢端分段上之連接器451、452、453、 454、455及456形成介面（如第9Β圖所示)。這些連接器提供 30 200824662 一供信號穿過一梢端分段與一有限重覆使用總成間之路 徑。 第12圖為根據本發明的一實施例之一有限重覆使用總 成的橫剖視圖。第12圖中，有限重覆使用總成250包括機械 5 連桿介面545、致動器轴510、致動器515、功率源505、控 制器305、有限重覆使用總成殼體255、介面535、有限重覆 使用總成介面連接器551、位移感測器1215、功率源控制器 444、及電感性元件1225。 * . 位移感測器1215測量致動器軸510的運動。位移感測器 10可能為一光學旋轉編碼器、一線性編碼器、一電流感測電 路（霍爾感測器）、一旋轉電位計、或一線性電位計、及其他。 其他實施例中，位移感測器能夠偵測致動器515是否動彈不 得。譬如，一霍爾感測器可偵測藉由致動器515之一增加電 流吸取，其指示出動彈不得的狀況。位移感測器1215亦可 15測量來自致動器515之背電動勢。位移感測器1215可包含單 一組件或多重組件。與本發明原理呈現一致之一實施例 中，位移感測器1215包括一用於測量致動器軸510移行距離 之裝置及一用於偵測致動器515是否動彈不得之裝置。 .位移感測器1215測量致動器軸51〇的位置。因為機械連 20桿介面545連接至致動器轴51〇,位移感測器1215亦測量其 位置。此位移感測器1215可用來決定是否輸送一完整劑 里。若位移感測器1215偵測出致動器軸51〇已移行一對應於 機械連桿介面545及柱塞415運動之特定距離，則已知已自 針頭210驅出一特定劑量。在將一藥物輸送至眼中之案例 31 200824662 中’位移感測器1215提供有關致動器軸510運動之資訊，其 可用來決定是否已輸送完整劑量。 部分案例中，致動器515可能動彈不得，故無法將致動 器軸510、機械連桿介面545、及柱塞415驅動適當距離以輸 5送一完整劑量的藥物至一眼中。在此例中，位移感測器1215 測里致動器軸510、機械連桿介面545、及柱塞415已移行之 距離。可自此距離資訊計算出一輸送藥物量。譬如，當配 送室405為圓柱形時，其橫剖面積為已知。位移感測器1215 所測量的距離隨後變成圓柱高度，且可容易計算出位移的 10容積（譬如藉由控制器305)。可經由^諸如顯示器320等顯示 器連同一動彈不得的指示來導通此輸送量（第3圖）。 位移感測器1215亦可提供在藥物輸送製程中為有用之 其他貧訊。譬如，當一梢端分段連接至一有限重覆使用總 成時，致動器軸510可被抽出或帶到一歸始位置以供連接一 15梢端分段。位移感測器1215可測量致動器軸51〇至此歸始位 置之運動。致動器轴510可放置在一歸始位置中以容許一梢 端分段被附接至一有限重覆使用總成或在輸送一藥物之 前。一實施例中，致動器515被啟動以將一藥物輸送至眼中 之前，可利用自位移感測器1215讀取的資訊來確認致動器 20 軸510位於一歸始位置中。 第12圖的實施例亦包括功率源控制器444及電感性元 件1225。當功率源505譬如為一可再充電式電池時，這兩個 組件控制功率源505的充電。功率源控制器444包括可進行 有關充電、監測、及維護功率源5015之數個不同功能的任 32 200824662 心者之包路。其他實施例中，功率源444可實行或整合於控 制器305中。 本發明的一實施例中，功率源控制器444(或控制器 3〇5依案例而定)係計數有限重覆使用總成250已使用之次 5數片數抵達一預定安全使用次數之後，有限重覆使用總 成250_除。或者，功率源控制器444(或控制㈣$，依 案例而定）計數功率源5〇5已充電的次數（功率源5〇5已承受 的充電循環數）。當計數抵達一預定低限值時，有限重覆使 用總成250被解除。本發明的其他實施例中，功率源控制器 10 444(或控制器305，依案例而定)偵測功率源5〇5的失效狀況 或其他不安全狀況並防止進一步使用有限重覆使用總成 250。 為了充電功率源505，當放置成接近一充電基底（未圖 不）中的另一電感性元件時在電感性元件1225中誘發一電 15 流。此誘發電流將功率源505充電。 第13圖為根據本發明的一實施例之一有限重覆使用總 成的橫剖視圖。第12圖中，有限重覆使用總成250包括機械 連桿介面545、致動器軸510、致動器515、功率源505、控 制器305、有限重覆使用總成殼體255、介面535、有限重覆 20使用總成介面連接器551、位移感測器1215、功率源控制器 444、及充電接觸部1235 〇 第13圖的實施例中，接觸部1235與一充電基底（未圖示) 上的接觸部形成介面以將功率提供至功率源505。一實施例 中，接觸部1235為諸如具有對接站的可攜式電子裝置所使 33 200824662 用之一 USB型連接。一實施例中，採用一 Molex®CradleConTM連接器。亦可使用其他類型連接器。 第14及15圖為根據本發明原理之兩次總成的橫剖視 圖。這些次總成各描繪從致動器515至針頭21〇之路徑。第 5 14圖描繪一剛性地連接至致動器軸510之機械連桿介面 - 545，而第15圖描繪一具有一球關節805之機械連桿介面 • 545。使用球關節805可辅助機械連桿介面545對準於柱塞介 面 420。 第14圖中，致動器515具有一剛性地連接至機械連桿介 ίο面545之致動為轴51〇。機械連桿介面對接於柱塞介面42〇。 柱塞415配置於配送室殼體425内且密封抵住配送室殼體 425的一内侧表面。配送室4〇5被配送室殼體425的一内部表 面及柱塞415的遠面所接壤。溫度控制裝置45〇至少部份地 圍繞配送室殼體425。針頭21〇流體式耦合至配送室4〇5。 15 第15圖中，致動為515具有一經由一球關節被連接至軸 φ 810之致動器軸510。機械連桿介面545經由球關節8〇5可旋 • 轉地連接至軸810。機械連桿介面對接於柱塞介面420。柱 基415配置於配送室殼體425内且密封抵住配送室殼體425 一 的一内侧表面。配送室405被配送室殼體425的一内部表面 20及柱塞415的遠面所接壤。溫度控制裝置450至少部份地圍 繞配送室殼體425。針頭210流體式耦合至配送室4〇5。 第14及15圖中，致動器515驅動致動器軸51〇往上(在朝 向針碩210的一方向中）。轉而言之，機械連桿介面545亦被 往上驅動。當機械連桿介面545對接於柱塞介面420時，柱 34 200824662 塞420亦被移動往上。一圍堵於配送室4〇5中之物質經由針 頭210被驅出。利用此方式，動作及力量自致動器軸51〇被 轉移至機械連桿介面545至柱塞415。 當配送室405含有一將被輸送至一眼中的藥物時，第14 5至15圖的組態在自眼睛移除針頭時消除逆流。柱塞415的動 作係位於單一方向（使配送室405中的藥物驅出之方向）中。 當機械連桿介面545在一遠離針頭210的方向中移動時，譬 如藥物已注射至眼中之後，柱塞415保持在定位中。因為柱 塞415未剛性地連接至機械連桿介面545，當機械連桿介面 10 545縮回時柱塞415並未縮回。 弟16圖為弟13圖的有限重覆使用總成及一充電基底之 橫剖視圖。第16圖中，有限重覆使用總成250的一底表面與 充電基底1615形成介面。當有限重覆使用總成250休止於充 電基底1615中時，功率源505可被充電。被充電之後，有限 15重覆使用總成250可自充電基底1615被移除。本發明的一實 施例中，具有一經附接梢端分段205之有限重覆使用總成 250被放置在充電基底1615中且一位居配送室405中的物質 被溫度控制裝置450加熱或冷卻。利用此方式，充電基底 1615提供用於溫度控制裝置450之功率。當位居配送室405 20中的物質已抵達適當溫度(如從熱感測器460的資訊所決定) 時，具有經附接梢端分段205之有限重覆使用總成250可自 充電基底被移除。當有限重覆使用總成250及經附接梢端分 段205自充電基底1615移除時，這節省了用於注射製程之功 率源505。 35 200824662 弟17A及17B圖為根據本發明原理之一用於將一物質 注射至一眼中之方法的流程圖。17〇5中，辨識一梢端分段 及一有限重覆使用總成之間的一連接。第171〇中，識別連 接至有限重覆使用總成之梢端分段類型。譬如，可識別— 5藥物輸送梢端分段或藥物輸送梢端分段類型。可藉由自梢 端分段讀取資訊、譬如藉由自記憶體或RFID標籤讀取資訊 來發生此識別。1715中，自梢端分段接收劑量資訊。就像 有關梢端分段類型之資訊，劑量資訊可由一控制器、Rf出 讀取器、或有限重覆使用總成中的類似裝置自梢端分段中 10 的一記憶體裝置讀取。Figure 8 is a cross-sectional view of a portion of a finite overlap assembly and a disposable tip segment in accordance with an embodiment of the present invention. In Fig. 7, the 20 disposable tip segment 205 includes a housing 215, a needle 210, a plunger 415, a plunger interface 420, a delivery chamber 405, a delivery chamber housing 425, an RFID tag 1110, a temperature control device 450, Tip interface connector 452, and interface 462. A partial diagram of a finite reuse assembly depicts a mechanical linkage interface 545, an actuator shaft 510, an interface 535, a finite overlap assembly interface connector 552, an RFID 21 200824662 reader 1120, and an RFID interface 1130. . The embodiment of Figure 8 has the operation of the embodiment of Figures 6 and 7. The different components of the tip segment 20 5 of Figure 8 have the same features and substantially the same mode of operation as the similar components of Figures 6 and 7. However, the embodiment of Figure 8 uses an RFID system rather than a wiring assembly 555 to store and transfer information. The RFID reader 1120 is disposed proximate to the mechanical linkage interface 545, one of which finitely overlaps the use of the assembly top. The RFID tag is placed at the bottom of the tip section 205. The RFID reader 1120 is designed to read information from the RFID tag 1110. The RFID interface 1130 is connected to a controller 3〇5 (not shown). The RFID tag 1110 is configured to accommodate the same type of information that can be accommodated by the assembly 555 of the fifth to seventh embodiments. In this manner, the RFID tag 1110 is another type of memory. However, as is conventionally known, the RFID tag 1110 does not require a wire-to-wire connection for one of the RFID readers 1120. In this manner, a wireless connection can be established between the tip segment 205 (RFID tag 1110) and a limited reuse assembly 15 (RFID reader 1120). In one type of RFID system, i.e., a passive rFID system, the RFID tag 1110 does not have a power supply. Instead, the passive tag still has its power dependent on the electromagnetic field generated by the RFID reader 1120. The electromagnetic field generated by the RFID reader 112A and the RFID reader antenna (not shown) induces a small current in the 20 RFID tag 1110. This small current allows the RFID tag iiio to operate. In this passive system, the rFID tag is designed to collect power from the electromagnetic field emitted by the RFID reader 1120 and to transmit an outgoing signal received by the RFm reader ι2. In operation, an RFID reader antenna (not shown) transmits a signal generated by a *RFm read 22 200824662 1120. An RFID tag antenna (not shown) receives this signal and induces a small current in the RFID tag 111 〇. This small current supplies power to the sRFID tag 1110. The RFID tag 1110 can then send a signal via its RFID tag antenna to the RFID reader antenna and the RFID reader 1120 itself. In this manner, the RFH) tag 1110 and the RFID reader 1120 can be electrically connected to each other on a radio frequency connection. The RFID 1110 transmits information such as dose information or tip segmentation information to the RFID reader 1120 via the RFID tag antenna. This information is received by the RFID reader 1120. In this way, information can be transferred from the tip segment 2〇5 to the limited repetitive use assembly. The RFID reader 120 can send information to the RFID tag 1110 in a similar manner 10. For example, the rfid reader 1120 can transmit information such as dose information on the radio frequency signal transmitted by the RFID capture 1120. The RFID tag 1120 receives the radio frequency signal containing the information. The 1st tab 1110 can then store this information. Although the embodiment of Figure 8 is described as having an -RFn system, information can be transferred between a limited reuse assembly 250 and a tip segment 205 using any other type of wireless system. For example, a Bluetooth protocol can be used to establish a conductive connection between a limited reuse assembly 250 and a tip segment 205. Information can then be transferred between a limited repetitive use assembly 250 and a tip end segment 205 on this conductive link. Other embodiments for transferring information 20 include an infrared protocol, 802.11, fire wire, or other wireless protocol. In one embodiment, the RFID tag 1110 (or assembly 555) contains dose information. Information regarding the appropriate medication dosage for the medication contained in delivery chamber 405 can be included on RFID tag 1110 (or assembly 555). In this example, control 23 200824662 305 can read the dose information from RFID tag 1110 (or assembly 555) and operate actuator 515 in a manner suitable for delivering the appropriate dose. For example, the delivery chamber 405 can contain 100 microliters. Information may be stored on the RFID tag 1110 (or assembly 555) stating that 20 microliters of the dose is delivered to the eye. In this example, the controller 5 reads the dose information from the RFID tag 1110 (or assembly 555) (20 microliters should be delivered to the eye). Controller 305 can then operate actuator 515 to deliver a 20 microliter dose. The controller 3〇5 can cause the actuator 515 to move the actuator shaft 510 and the mechanical linkage interface 545 by a set distance associated with a 20 microliter dose. In this example, the plunger 415 is moved by this set distance so that only 2 microliters of drug is ejected from the needle 1 〇 210 and enters the eye. In another embodiment consistent with the principles of the present invention, the controller 3〇5 can count the distance that the different plunger 415 must move to deliver the desired dose. For example, if the controller 305 reads the dose information corresponding to the 20 microliter dose of the music from the RFID tag 1110 (or assembly 555), the controller 3〇5 can use the resource 15 to calculate the plunger 415 must be calculated. Move one of the appropriate distances. Because the volume of the dispensing chamber 405 and the volume of one of the medications contained in the dispensing chamber 405 are known, the controller 305 can be used to calculate the distance that the plunger 415 must move to deliver the desired dose. When the dispensing chamber 405 has a cylindrical shape, the volume of the dispensing chamber can be calculated by multiplying the cross-sectional area of the cylinder (and the area of the -IS shape) by the height of the dispensing chamber. This simple mathematical formula can be used to calculate the total volume of the delivery chamber 4〇5. Since the cross-sectional area of the dispensing chamber 405 is (4) for any given application, the height corresponding to the travel distance of the plunger 415 can be calculated for any dose amount. For example, assume that 1 〇〇 microliter of drug is loaded into the delivery chamber 4〇5 and the cross-sectional area of the delivery chamber 405 is ten. When the distribution chamber 4〇5 has a cylindrical shape, the height of the circle 24 200824662 column is also 10. In order to deliver a 20 microliter dose corresponding to 20% of the total volume of the dispensing chamber 405, the plunger 415 is moved up to the needle 210 to a distance of two. In other words, a 20 microliter dose corresponds to 20% of the total volume of the dispensing chamber 405. In this example, the plunger 415 should be moved upwardly toward the needle 210-segment by a distance equal to 20% of the total height of the dispensing chamber 405. The controller 305 can then control the actuation of the actuator 515 such that the actuator shaft 510 moves the plunger 415 upward by one of 20% of the total height of the dispensing chamber 405. • In addition, the controller 305 can read information about the rate at which the plunger 415 should be moved to properly transport the music agent. In this example, controller 305 10 reads information about the drug delivery rate from RFID tag 111 (or assembly 555) and uses this information to operate actuator 515 to drive the plunger at that rate. 415. The rate at which the plunger 415 moves can be fixed or variable. In some applications, it may be desirable to move the plunger 415 faster than in other applications. For example, when dispensing to 405 is a drug that should be heated prior to injection into the eye, it may be desirable to drive the plunger 415 at a rate such that the heated drug does not cool and clog the needle 210. In other applications, it may be desirable to slowly move the plunger 415 to improve delivery of a drug in the dispensing chamber 405. The RFID 111 (or assembly 555) may also include any other type of information regarding a drug delivery. For example, the RFID tag 111(R) (or assembly 555) can include information regarding the type of drug contained in the delivery chamber 405, the different characteristics of the drug, or other characteristics of an appropriate delivery in the appropriate agent or of the item. In addition, the RFID tag 111 (or assembly 555) may contain security information, information regarding proper operation of the tip segment 205, or any other information regarding the tip segment or the finite overlap assembly. 25 200824662 In another embodiment consistent with the principles of the invention, a dose can be selected by a medical professional who administers the drug. In this example, an input device (not shown) disposed on the limited reuse assembly 250 or the tip segment 2〇5 allows the physician to select the desired drug dose. In this example, controller 3〇5 5 receives the desired drug dose and operates actuator 515 to move plunger 415 a desired distance to deliver the desired dose. This user-selectable dosing regimen can be implemented simply by adding an additional input device. It may be desirable to include dose information on the RFID tag 111 (or assembly 555) so that the vehicle is less susceptible to dose errors. In this example, several different drug 10 delivery tip segments 205 may be manufactured and loaded with a drug at the factory. The dose information can also be loaded on the RFID tag 111 (or assembly 555) at the factory. In this example, a plurality of different tip segments each having the same amount of drug in the dispensing chamber 405 but having different dose information stored on the RFID tag 111 (or assembly 555) can be manufactured and shipped. The physician can then order the tip segment 205 with the desired dose information on the rFID tag 111 (or assembly 15 555). The package can be clearly labeled to identify dose information such that the appropriate dose is administered to a patient. Figure 9A is a cross-sectional view of a disposable tip segment for an ophthalmic medical device in accordance with one embodiment of the present invention. In FIG. 9, the disposable tip segment 205 includes a housing 215, a needle 210, a plunger 415, a plunger shaft 417, a second plunger interface 420, a dispensing chamber 405, a dispensing chamber housing 425, and an assembly 555. Temperature control device 450, thermal sensor 460, optional luer 430, tip interface connectors 452 and 453, interfaces 462 and 463, and signatures 472 and 473. The different components of the tip segment 205 of Figure 9 have the same features and the same mode of operation as the similar components of Figures 5-8. The embodiment package of Fig. 9 26 200824662 includes two signatures 472 and 473 of the joint-finite field. After the two tabs 472 and 473 are inserted into the slot, the tip assembly rotates 2〇5 to lock it into the positioning on the finite-repetition assembly. The two iron pieces 473 and 473 may be of different shapes or sizes to provide a suitable interface between the tip end segment 2〇5 and the finite overlap 5 use assembly. When the two iron pieces still have different shapes or sizes, the tip end segments 4〇5 are only fitted to a limited reuse assembly in a certain direction. In other embodiments of the invention, different shapes or sizes of tabs can be used with different shapes or sizes of slots on different limited repetitive use assemblies. In this manner, a number of different finite overlaps can be used to accommodate a variety of shapes or sizes of slots to accommodate tip segments 205 having complementary shapes or size signatures. Further, the embodiment of Fig. 9 includes a plunger shaft 417 coupled to the plunger 4i5. In this embodiment, the plunger 415 can be overmolded onto the plunger shaft 417. The column base shaft 417 is generally cylindrical in shape and has an intermediate diameter that is smaller than its distal and proximal ends. The plunger interface 420 is located on one of the proximal ends of the plunger shaft 417. The plunger shaft 417 is typically fabricated from a rigid material such as stainless steel. The column base 415 is made of a rubber or k composite material. In another embodiment of the invention, the distal end of the plunger shaft 417 has a lip on which the plunger 415 can be applied. The plunger 415 can be press fit into the plunger shaft 417 and held in position by a lip on the distal end of the plunger shaft 417. This allows for easier assembly. If the plunger 415 is not overmolded on a shaft, the plunger 415 can be made as a separate portion and pushed onto the distal end of the plunger shaft 417. The plunger interface 420 can have any suitable shape. Figure 9B is an end view of the tip segment of Figure 9A. The figure depicts the distal end segment 205 end of the needle 210. This end forms an interface with a finite overlap assembly 27 200824662. The rim housing 215, the plunger interface, the tip interface connectors 451, 452, 453, 454, 455 and 456, the tabs 472 and 473, and the alignment slot 481. In the second embodiment, the _ end of the plunger interface is not completely circular. It has a flat portion designed to align with a mechanical linkage interface having a similar cross-sectional shape. This optional feature is designed to allow for a tip end segment and a finite overlap assembly to be properly aligned. In other embodiments of the invention, the cross-sectional view of the 420 end of the plunger interface is circular. The embodiment of Figure 9B also includes an optional alignment slot to assist in properly aligning a 10 tip segment with a finite overlap assembly. The alignment slot 481 forms an interface with an alignment pin (shown as 581) on a finite overlap assembly. In another embodiment of the invention, the signatures 472 and 473 have different sizes. Alternatively, the wearing sheets 472 and 473 may have different shapes. The two iron pieces 472 and 473 also assist in aligning a tip end segment with a limited repetitive use assembly by forming an interface with the grooves 572 and 573 of Fig. 11. In one embodiment consistent with the principles of the present invention, a tip end segment is placed over a limited reuse assembly to allow the tabs 472 and 473 to be inserted into slots 572 and 579. The tip segment is then rotated relative to the finite overlap assembly so that the tabs 472 and 473 are held in slots 572 and 573. The alignment pin 581 and alignment slot 20 481 are then properly aligned. Connectors 451, 452, 453, 454, 455 and 456 electrically connect the tip end segments to a finite overlap assembly. Connectors 451, 452, 453, 454, 455, and 456 form interfaces with similar connectors 551, 552, 553, 554, 557, and 556, respectively, on a finite overlap assembly (as shown in Figure 11). 28 200824662 These connectors provide a path for signals to pass between a tip end segment and a finite overlap assembly. The brothers 10A-10D are diagrams of four different circuits that can be included in an embodiment of the present invention. Figure 10A shows one of the many different configurations for the temperature control device 450. In Fig. 10A, temperature control device 450 is coupled to connectors 452 and 455. Power and/or control signals are provided to temperature control device 450 via connectors 452 and 455. FIG. 10B shows one of many configurations for thermal sensor 460. In Fig. 10B, thermal sensor 460 is coupled to connectors 451 and 454. Signals are received from thermal sensor 460 via connections 451 and 454. Figure 10C shows one of many different configurations for a fuse ion. The fuse 1011 can be included in the assembly 555 or can be implemented as shown in Figure lC. In Fig. 10C, the fuse 1〇11 is connected between the connectors 453 and 456. In this embodiment, the fuse 1011 is used to ensure that the tip end body is a single use I5. The fuse 1011 is burned out when the heating button is activated or after the disposable tip segment 2〇5 is used. As described above, a controller in a finite overlap assembly detects when a connected tip segment has been used and directs an increased current through the fuse loii to thereby burn the filament. When the filaments are burned, the tip segments are no longer operational and must be disposed of. 20 Figure 1 shows one of the many configurations for the assembly 555. In the first diagram, the assembly 555 is connected to the connectors 453 and 456. Power and/or control signals are provided to assembly 555 via connectors 453 and 456. Many other groups of connectors 451, 452, 453, 454, 4M, and 456 can be implemented. For example, although six connectors are shown, any number of 29 200824662 connectors can be implemented. The sub-portion can include any combination of different circuits in a tip segment. Fig. = is an end view of a finite overlap assembly according to the principles of the present invention. The end of the finite overlap using assembly shown in Fig. 11 forms an interface with the tip end shown in Fig. 9B. The end view of the limited repetitive use assembly depicted in Figure 11 shows the housing 255, the mechanical linkage interface 545, the finite overlap assembly interface connector 55, 552, 553, 554, 557 and 556, slots 572 and 573. And alignment pin 581. In the embodiment of the second diagram, one end of the mechanical linkage interface 545 is not completely circular. It has a flat portion that is designed to be aligned with a plunger interface having a similar cross-sectional shape. This optional feature is designed to allow for proper alignment of a tip end segment and a finite overlap assembly. In other embodiments of the invention, a cross-sectional view of one end of the mechanical linkage interface 545 is circular. The embodiment of Fig. 11 also includes an optional alignment slot 581 to assist in properly aligning a 15 tip segment with a finite overlap assembly. The alignment pin 581 forms an interface with one of the alignment segments (481 shown in Fig. 9). In other embodiments of the invention, slots 572 and 573 have different sizes. Alternatively, slots 572 and 573 can have different shapes. The two slots 572 and 573 also assist in the alignment of the tip end 20 segments with a finite overlap assembly by forming an interface with the tabs 472 and 473 of the tip segment shown in Figure 9B. Connectors 551, 552, 553, 554, .557, and 556 electrically connect the tip end segments to a finite overlap assembly. Connectors 551, 552, 553, 554, 557, and 556 form interfaces with connectors 451, 452, 453, 454, 455, and 456 on a tip end segment (as shown in Figure 9). These connectors provide 30 200824662 a path between the signal passing through the tip end segment and a limited repeat use assembly. Figure 12 is a cross-sectional view of a finite overlap use assembly in accordance with an embodiment of the present invention. In Fig. 12, the finite overlap assembly 250 includes a mechanical 5-link interface 545, an actuator shaft 510, an actuator 515, a power source 505, a controller 305, a finite overlap assembly housing 255, an interface 535. The finite overlap uses the assembly interface connector 551, the displacement sensor 1215, the power source controller 444, and the inductive component 1225. The displacement sensor 1215 measures the motion of the actuator shaft 510. The displacement sensor 10 may be an optical rotary encoder, a linear encoder, a current sensing circuit (Hall sensor), a rotary potentiometer, or a linear potentiometer, among others. In other embodiments, the displacement sensor can detect if the actuator 515 is not moving. For example, a Hall sensor can detect an increase in current draw by one of the actuators 515, which indicates a condition in which the move is not possible. The displacement sensor 1215 can also measure the back electromotive force from the actuator 515. Displacement sensor 1215 can comprise a single component or multiple components. In one embodiment consistent with the principles of the present invention, the displacement sensor 1215 includes a means for measuring the travel distance of the actuator shaft 510 and a means for detecting whether the actuator 515 is movable. The displacement sensor 1215 measures the position of the actuator shaft 51A. Since the mechanical 20-pole interface 545 is coupled to the actuator shaft 51, the displacement sensor 1215 also measures its position. This displacement sensor 1215 can be used to determine whether or not to deliver a complete dose. If the displacement sensor 1215 detects that the actuator shaft 51 has moved a particular distance corresponding to the movement of the mechanical linkage interface 545 and the plunger 415, it is known that a particular dose has been expelled from the needle 210. In the case of delivering a drug to the eye 31 200824662, the 'displacement sensor 1215 provides information about the movement of the actuator shaft 510, which can be used to determine if a full dose has been delivered. In some cases, the actuator 515 may not move, so the actuator shaft 510, the mechanical linkage interface 545, and the plunger 415 cannot be driven at an appropriate distance to deliver a full dose of medication to one eye. In this example, displacement sensor 1215 measures the distance that actuator shaft 510, mechanical linkage interface 545, and plunger 415 have moved. The amount of drug delivered can be calculated from this distance information. For example, when the dispensing chamber 405 is cylindrical, its cross-sectional area is known. The distance measured by the displacement sensor 1215 then becomes a cylinder height and the volume of displacement can be easily calculated (e.g., by controller 305). This amount of conveyance can be turned on via a display such as the display 320 to the same movable state (Fig. 3). Displacement sensor 1215 may also provide other information that is useful in the drug delivery process. For example, when the tip end segment is coupled to a finite overlap use assembly, the actuator shaft 510 can be withdrawn or brought to a home position for attachment to a 15 tip segment. Displacement sensor 1215 can measure the motion of actuator shaft 51 〇 to this home position. The actuator shaft 510 can be placed in a home position to allow a tip segment to be attached to a limited reuse assembly or prior to delivery of a medicament. In one embodiment, prior to actuation of the actuator 515 to deliver a drug to the eye, information read from the displacement sensor 1215 can be utilized to confirm that the actuator 20 shaft 510 is in a home position. The embodiment of Fig. 12 also includes a power source controller 444 and an inductive component 1225. When the power source 505 is, for example, a rechargeable battery, the two components control the charging of the power source 505. Power source controller 444 includes any of the various functions that can be used to charge, monitor, and maintain several different functions of power source 5015. In other embodiments, power source 444 can be implemented or integrated into controller 305. In an embodiment of the present invention, the power source controller 444 (or the controller 3〇5, depending on the case) counts the number of times the finite number of repeated use assemblies 250 have been used for a predetermined number of safe uses. Limited reuse using assembly 250_ divided. Alternatively, power source controller 444 (or control (four) $, depending on the case) counts the number of times power source 5 〇 5 has been charged (the number of charging cycles that power source 5 〇 5 has withstood). When the count reaches a predetermined low limit, the limited repeat use assembly 250 is released. In other embodiments of the present invention, power source controller 10 444 (or controller 305, as the case may be) detects a failure condition or other unsafe condition of power source 5〇5 and prevents further use of limited reuse assembly. 250. To charge power source 505, a current 15 is induced in inductive element 1225 when placed in proximity to another inductive component in a charging substrate (not shown). This induced current charges the power source 505. Figure 13 is a cross-sectional view of a finite overlap use assembly in accordance with an embodiment of the present invention. In FIG. 12, the finite overlap assembly 250 includes a mechanical linkage interface 545, an actuator shaft 510, an actuator 515, a power source 505, a controller 305, a finite overlap assembly housing 255, and an interface 535. The finite overlap 20 uses the assembly interface connector 551, the displacement sensor 1215, the power source controller 444, and the charging contact portion 1235. In the embodiment of FIG. 13, the contact portion 1235 and a charging substrate (not shown) The contacts on the interface form an interface to provide power to the power source 505. In one embodiment, the contact portion 1235 is a USB type connection for use with a portable electronic device such as a docking station. In one embodiment, a Molex® CradleConTM connector is employed. Other types of connectors are also available. Figures 14 and 15 are cross-sectional views of two assemblies in accordance with the principles of the present invention. These secondary assemblies each depict a path from actuator 515 to needle 21〇. Figure 5 depicts a mechanical linkage interface - 545 rigidly coupled to the actuator shaft 510, while Fig. 15 depicts a mechanical linkage interface 545 having a ball joint 805. The use of ball joint 805 assists in aligning mechanical linkage interface 545 with plunger interface 420. In Fig. 14, the actuator 515 has an actuation that is rigidly coupled to the mechanical linkage 545. The mechanical link faces the plunger interface 42〇. The plunger 415 is disposed within the dispensing chamber housing 425 and seals against an inner side surface of the dispensing chamber housing 425. The dispensing chamber 4〇5 is bordered by an internal surface of the dispensing chamber housing 425 and a distal surface of the plunger 415. The temperature control device 45 is at least partially surrounding the dispensing chamber housing 425. The needle 21 is fluidly coupled to the dispensing chamber 4〇5. In Fig. 15, actuation 515 has an actuator shaft 510 that is coupled to shaft φ 810 via a ball joint. The mechanical linkage interface 545 is rotatably coupled to the shaft 810 via a ball joint 8〇5. The mechanical linkage faces the plunger interface 420. The column base 415 is disposed within the dispensing chamber housing 425 and seals against an inner side surface of the dispensing chamber housing 425. The dispensing chamber 405 is bordered by an interior surface 20 of the dispensing chamber housing 425 and a distal face of the plunger 415. Temperature control device 450 at least partially surrounds distribution chamber housing 425. The needle 210 is fluidly coupled to the dispensing chamber 4〇5. In Figs. 14 and 15, the actuator 515 drives the actuator shaft 51 upward (in a direction toward the needle 210). In other words, the mechanical linkage interface 545 is also driven upward. When the mechanical linkage interface 545 is docked to the plunger interface 420, the post 34 200824662 plug 420 is also moved upward. A substance enclosed in the dispensing chamber 4〇5 is driven out through the needle 210. In this manner, motion and force are transferred from the actuator shaft 51 to the mechanical linkage interface 545 to the plunger 415. When the dispensing chamber 405 contains a drug to be delivered to one eye, the configuration of Figures 14 to 15 eliminates backflow when the needle is removed from the eye. The action of the plunger 415 is in a single direction (the direction in which the drug in the delivery chamber 405 is driven out). When the mechanical linkage interface 545 is moved in a direction away from the needle 210, such as after the drug has been injected into the eye, the plunger 415 remains in position. Because the plunger 415 is not rigidly coupled to the mechanical linkage interface 545, the plunger 415 is not retracted when the mechanical linkage interface 10 545 is retracted. Figure 16 is a cross-sectional view of the finite overlap assembly and a charging base of the Figure 13. In Fig. 16, a bottom surface of the finite overlap assembly 250 forms an interface with the charging substrate 1615. Power source 505 can be charged when limited repetitive use assembly 250 rests in charging substrate 1615. After being charged, the limited 15 re-use assembly 250 can be removed from the self-charging substrate 1615. In one embodiment of the invention, a limited repetitive use assembly 250 having an attached tip end segment 205 is placed in the charging base 1615 and a substance in the dispensing chamber 405 is heated or cooled by the temperature control device 450. . In this manner, the charging substrate 1615 provides power for the temperature control device 450. When the substance in the dispensing chamber 405 20 has reached a suitable temperature (as determined by information from the thermal sensor 460), the limited repetitive use assembly 250 with the attached tip end segment 205 can be self-charging the substrate. Was removed. This saves power source 505 for the injection process when the limited repetitive use assembly 250 and the attached tip end segment 205 are removed from the charging substrate 1615. 35 200824662 Figures 17A and 17B are flow diagrams of a method for injecting a substance into an eye in accordance with one of the principles of the present invention. In 17〇5, a connection between the tip end segment and a finite overlap assembly is identified. In Section 171, identify the tip segment type that is connected to the finite reuse assembly. For example, identifiable - 5 drug delivery tip segmentation or drug delivery tip segmentation type. This identification can occur by reading information from the tip segment, such as by reading information from a memory or RFID tag. In 1715, dose information is received from the tip end segment. As with the information on the tip segment type, the dose information can be read from a memory device in the tip segment 10 by a controller, Rf out reader, or similar device in a finite overlap assembly.

Π20中，啟動一溫度控制裝置以更改位居配送室中之 物質的溫度。物質可如前述被加熱或冷卻。此外，加熱曳 冷卻可只發生於梢端分段及有限重覆使用總成位居一充填 基底上之時。1725中，自一接近於設有該物質的配送室之 15熱感測器接收溫度資訊。1730中，利用此溫度資訊來抑制 溫度控制裝置以調節物質的溫度。 Π35中，致動器軸被移動至一歸始位置。嬖如， 。 口 双動 器軸可完全地縮回以建立一歸始位置。歸始位置可建立對 於一位移感測器之一參考點。易言之，位移感测器可開始 20測量致動器軸自歸始位置之運動。1740中，致動器轴移動 直 到機械連桿介面（其與致動器軸為一體或與之連接)接觸 孝主塞介面為止。在此位置中，致動器軸的任何進一步運動 將導致物質自配送室之驅排。當機械連桿介面接觸於板夷 介面時，裝置可就緒用來將物質注射至眼中。此步驟發生 36 200824662 於物質注射於眼中之前使該物質可維持在一用於注射的適 S 度。譬如，物質可在梢端分段及有限重覆使用總成位 居一充電基底上之時被加熱或冷卻。當梢端分段及有限重 覆使用總成自充電基底被移除時，醫師在物質溫度落至適 5當溫度範圍外之前可具有一有限時間期間來進行注射。使 機械連桿介賴觸於柱塞介面將可容許在—短時間量中進 行注射。 10 15 20 1745中，接收一用於指示物件將被輸送至眼中之輸 入。譬如，醫師可壓抵一按鈕藉以將一信號送到控制器用 於指示致動n將被麟輯送錄f。175时，利用劑量 資訊來控制致動器的操作以騎速率來輸送適當劑量。該 物質只在其位於適當溫度範圍巾之後被輸送至眼中。1755 中’自位移感測11接收資訊。此資訊指示致動器軸已移行 多遠。致動器軸已移行的距離係與—劑量相關聯。轴已移 行愈遠，則柱塞已位移愈大，且劑量輸送愈大。176〇中， 提供所輸送劑量之-指示。譬如，可由—綠燈光或一數量 (以微升代表輸賴質之量）來——其巾已成功輸送一完 全劑量之成功注射。-不成功注射中，顯示實際輸送的物 質量。1765中，料藉由燒_端分段巾的…職來防止 重覆使用梢端分段。 第18圖為根據本發明原理之-有關將-物質注射至眼 中之方法的流㈣。㈣圖崎—啟動溫度控制裝置以加 熱或冷卻位於配送室中的物_時梢端分段及有限重覆使 用總成位居-充電站中之方法。_中，辨識-梢端分段 37 200824662 與一有限重覆使用總成之一連接。1810中，識別梢端分段 的類型。1815中，自梢端分段接收劑量資訊。1820中，決 定梢端分段及有限重覆使用總成是否位居充電基底上。若 其不位居充電基底上，則1825中，系統等待且回到1820。 5 若梢端分段及有限重覆使用總成位居充電基底上，則1830 中，溫度控制裝置被啟動以更改配送室中所含物質的一溫 度。1835中，自一熱感測器接收溫度資訊。1840中，利用 此溫度資訊來控制溫度控制裝置。 第19圖為根據本發明原理之一有關將一物質注射至一 10 眼中之方法的流程圖。第19圖描繪一有關決定是否已輸送 適當劑量之方法。1910中，以一劑量速率資訊為基礎來控 制致動器。致動器移動柱塞以輸送該物質。1920中，自位 移感測器接收指示出致動器軸已移動距離之資訊。1930 中，利用此距離資訊來決定是否已輸送一適當劑量。若致 15 動器軸已移動輸送適當劑量所需要的距離，則1940中，提 供已輸送適當劑量之一指示。若致動器軸尚未移動輸送適 當劑量所需要的距離，則1950中，以致動器軸已移動距離 為基礎來計算所輸送劑量。1960中，提供所輸送劑量之一 指示。 20 第20圖為根據本發明原理之一有關將一物質注射至眼 中之方法的流程圖。第20圖有關致動器軸已動彈不得之情 境。2010中，以一劑量及劑量速率資訊為基礎來控制致動 器。致動器移動柱塞以輸送該物質。2020中，自一動彈不 得感測器接收資料。2030中，利用此資料來決定致動器軸 38 200824662 若軸已動彈不得，則2_中，提供動彈In Π20, a temperature control device is activated to change the temperature of the substance in the dispensing chamber. The substance can be heated or cooled as previously described. In addition, heating drag cooling can only occur when the tip segment and the limited repeat assembly are placed on a filling substrate. In 1725, temperature information is received from a thermal sensor that is close to the dispensing chamber in which the substance is placed. In 1730, this temperature information is used to suppress the temperature control device to regulate the temperature of the substance. In Π35, the actuator shaft is moved to a home position. For example, . The double-acting shaft can be fully retracted to establish a home position. The home position can establish a reference point for one of the displacement sensors. In other words, the displacement sensor can begin to measure the movement of the actuator shaft from the home position. In 1740, the actuator shaft moves until the mechanical link interface (which is integral with or connected to the actuator shaft) contacts the filial plug interface. In this position, any further movement of the actuator shaft will result in the expulsion of the substance from the dispensing chamber. When the mechanical link interface is in contact with the interface, the device is ready to inject the substance into the eye. This step occurs 36 200824662 to maintain the substance at an appropriate S for injection prior to injection into the eye. For example, the material can be heated or cooled while the tip segment and the finite overlap assembly are on a charging substrate. When the tip segment and the finite overlap assembly are removed from the charging substrate, the physician may have a limited time period for the injection before the material temperature falls outside the temperature range. Incorporating the mechanical linkage to the plunger interface allows for injection in a short amount of time. In 10 15 20 1745, an input is received to indicate that the item will be delivered to the eye. For example, the physician can press a button to send a signal to the controller for indicating that the actuation n will be recorded by the lining f. At 175 hours, dose information is used to control the operation of the actuator to deliver the appropriate dose at the ride rate. The substance is delivered to the eye only after it is in the proper temperature range. In 1755, 'self-displacement sensing 11 receives information. This information indicates how far the actuator shaft has moved. The distance the actuator shaft has moved is associated with the dose. The farther the axis has moved, the greater the displacement of the plunger and the greater the dose delivery. In 176, the indication of the delivered dose is provided. For example, it can be a green light or a quantity (in microliters representing the amount of fat) - the towel has successfully delivered a full dose of successful injection. - In the case of an unsuccessful injection, the actual delivered mass is displayed. In 1765, it was expected to prevent repeated use of the tip segment by the job of burning the end segment. Figure 18 is a flow (four) of a method for injecting a substance into the eye in accordance with the principles of the present invention. (d) Tuqi—Starting the temperature control device to heat or cool the material in the distribution chamber, the tip end segment and the finite overlap use assembly in the charging station. _ Medium, Identification - Tip Segment 37 200824662 Connected to one of the finite repeat assemblies. In 1810, the type of tip segmentation is identified. In 1815, the dose information is received from the tip end segment. In the 1820, it was determined whether the tip segment and the finite overlap assembly were on the charging substrate. If it is not on the charging substrate, then in 1825, the system waits and returns to 1820. 5 If the tip segment and the finite overlap assembly are located on the charging substrate, then in 1830, the temperature control device is activated to change a temperature of the material contained in the dispensing chamber. In 1835, temperature information is received from a thermal sensor. In 1840, this temperature information is used to control the temperature control device. Figure 19 is a flow chart showing a method of injecting a substance into a 10 eye in accordance with one of the principles of the present invention. Figure 19 depicts a method for deciding whether a proper dose has been delivered. In 1910, the actuator is controlled based on a dose rate information. The actuator moves the plunger to deliver the substance. In 1920, the self-aligning sensor receives information indicating that the actuator shaft has moved. In 1930, this distance information is used to determine if an appropriate dose has been delivered. If the distance required to deliver the appropriate dose has been moved, then in 1940, an indication that one of the appropriate doses has been delivered is provided. If the actuator shaft has not moved the distance required to deliver the appropriate dose, then in 1950, the delivered dose is calculated based on the distance the actuator shaft has moved. In 1960, an indication of one of the delivered doses is provided. 20 Figure 20 is a flow diagram of a method of injecting a substance into the eye in accordance with one of the principles of the present invention. Figure 20 shows the situation where the actuator shaft has been moved. In 2010, the actuator was controlled based on a dose and dose rate information. The actuator moves the plunger to deliver the substance. In 2020, the sensor does not receive data from a moving bullet. In 2030, use this information to determine the actuator shaft. 38 200824662 If the shaft has not moved, then 2_, provide the moving bullet

不仵狀況之一指示。2050中，自—A 仅移感測器接收指示致 動-軸移動距離之資料。2〇6〇中， ^ 乂距離貧訊為基礎來提 保所輸迗劑1之一指示。若軸黑去 切 釉向未動彈不得，則2070中， 提供一已輸送適當劑量之指示。 10 15 20 併=上文，可瞭解本發明提供1於將精密容積的-物 •、匕至眼巾之城良的系統及方法。本發明提供能夠 輪送—精㈣量之單次❹、可抛棄式輸送裝置梢端分 &。梢端分段與-有限重覆使用總成形成介面。本發明在 此處以範例示範，-般熟習該技術者可作出不同修改。 雖然就單次使用藥物輸送裝置來描述本發明，本發明 涵盍任何與一電力源形成介面之單次使用醫療裝置。熟習 ϋ亥技術者將從說明書及此處所揭露的本發明之實行來得知 本發明的其他實施例。說明書及範例預定只視為示範性， 本發明的真實範圍及精神由申請專利範圍所界定。 【圖式簡單說明】 第1圖為一先前技藝注射器之立體圖； 第2圖為根據本發明的一實施例之包括一可拋棄式梢 端分段及一有限重覆使用總成之眼用醫療裝置的圖式； 第3圖為根據本發明原理之一有限重覆使用總成的另 實施例； 第4圖為根據本發明原理之一有限重覆使用總成的另 一實施例之横剖視圖； 第5圖為根據本發明的一實施例之一可抛棄式梢端分 39 200824662 段及一有限重覆使用總成的橫剖視圖； 第6圖為根據本發明的一實施例之— 裝置之可拋棄式梢端分段的橫剖視圖； 第7圖為根據本發明的一實施例之— 5 裝置之可拋棄式梢端分段的橫剖視圖； 第8圖為根據本發明的一實施例之— 段的橫剖視圖及一有限重覆使用總成的部份圖； 用於一眼用醫療 用於一眼用醫療 可抛茶式梢端分Not indicated by one of the conditions. In 2050, the self-A only shift sensor receives information indicating the movement distance of the actuator-axis. 2〇6〇, ^ 乂 is based on the poor news to ensure that one of the instructions for the transport agent 1 is. If the shaft is black and the glaze is not moving, then in 2070, an indication that the appropriate dose has been delivered is provided. 10 15 20 and above, it will be appreciated that the present invention provides a system and method for providing a precision volume of material to the eye. The present invention provides a single-twist, disposable conveyor tip that can be rotated-prepared (four). The tip segmentation and the finite overlap use the assembly to form an interface. The invention is exemplified herein by way of example, and various modifications may be made by those skilled in the art. Although the present invention has been described in terms of a single use of a drug delivery device, the present invention encompasses any single use medical device that forms an interface with a power source. Other embodiments of the present invention will be apparent to those skilled in the art from this disclosure. The specification and examples are intended to be exemplary only, and the true scope and spirit of the invention is defined by the scope of the claims. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a prior art syringe; FIG. 2 is an ophthalmic medical treatment including a disposable tip segment and a limited repetitive assembly according to an embodiment of the invention. Figure 3 is a further embodiment of a finite overlap assembly in accordance with the principles of the present invention; and Figure 4 is a cross-sectional view of another embodiment of a finite overlap assembly in accordance with the principles of the present invention. Figure 5 is a cross-sectional view of a disposable tip end 39 200824662 segment and a finite overlap assembly in accordance with an embodiment of the present invention; and Figure 6 is a view of an apparatus according to an embodiment of the present invention. A cross-sectional view of a disposable tip segment; Figure 7 is a cross-sectional view of a disposable tip segment of a device in accordance with an embodiment of the present invention; and Figure 8 is an embodiment in accordance with an embodiment of the present invention. - a cross-sectional view of the segment and a partial view of the finite reuse assembly; for one-eye medical use for one-eye medical disposable tea-type tip

第9A圖為根據本發明的一實施例之_用於一眼用醫療 裝置之可拋棄式梢端分段的橫剖視圖； 10 第9B圖為第9A圖的實施例之端視圖； 弟10A-10D圖為可被包括在根據本發明的實施例中之 四個不同電路的示意圖。 第11圖為根據本發明原理之一有限重覆使用總成的端 視圖， 第12圖為根據本發明的一實施例之一有限重覆使用總 成的橫剖視圖； 第13圖為根據本發明的一實施例之一有限重覆使用總 成的橫剖視圖； 第14及15圖為根據本發明原理之兩次總成的橫剖視 20圖； 第16圖為根據本發明原理之一有限重覆使用總成、梢 端分段、及一充電基底的橫剖視圖； 第17A及17B圖為根據本發明原理之一用於將一物質 注射至一眼中之方法的流程圖； 40 200824662 第18圖為根據本發明原理之一有關將一物質注射至一 眼中之方法的流程圖； 第19圖為根據本發明原理之一有關將一物質注射至一 眼中之方法的流程圖； 5 第20圖為根據本發明原理之一有關將一物質注射至一 眼中之方法的流程圖。 【主要元件符號說明】Figure 9A is a cross-sectional view of a disposable tip segment for an ophthalmic medical device in accordance with an embodiment of the present invention; 10 Figure 9B is an end view of the embodiment of Figure 9A; Brother 10A-10D The figure is a schematic diagram of four different circuits that can be included in an embodiment in accordance with the invention. 11 is an end view of a finite overlap assembly according to one of the principles of the present invention, and FIG. 12 is a cross-sectional view of a finite overlap assembly according to an embodiment of the present invention; FIG. 13 is a perspective view of the present invention. One of the embodiments is a cross-sectional view of the finite overlap assembly; Figures 14 and 15 are cross-sectional views of the two assemblies in accordance with the principles of the present invention; Figure 16 is a finite weight according to the principles of the present invention. A cross-sectional view of a cover assembly, a tip segment, and a charging substrate; Figures 17A and 17B are flow diagrams of a method for injecting a substance into an eye in accordance with one of the principles of the present invention; 40 200824662 Figure 18 BRIEF DESCRIPTION OF THE DRAWINGS FIG. 19 is a flow chart showing a method of injecting a substance into an eye in accordance with one of the principles of the present invention; FIG. 19 is a flow chart showing a method of injecting a substance into an eye in accordance with one of the principles of the present invention; A flow chart of a method of injecting a substance into an eye in accordance with one of the principles of the present invention. [Main component symbol description]

105,210···針頭 320…顯示器 110···路厄轂 330…殼體 115…室 340…有限重覆使用總成之端 120,415···柱塞 405…配送室 125,417…柱塞軸 420…柱塞介面 130···姆指靠座 425…配送室殼體 205···梢端區段 430…選用性路厄 215···梢端區段殼體 444…電力源控制器 250···有限重覆使用總成 450…溫度控制裝置 255···有限重覆使用總成殼體 451，452,453,454,455,456 …梢 260…螺紋式部分 端介面連接器 265,471…鎖機構 460…熱感測器 270…開關 461，462,463,517,530,535〜介面 275…選用性燈光 472,473···籤片 305…控制器 481…對準槽 306,307…指示器 505…電力源 308…按鈕 510…致動器軸 41 200824662 515···致動器 1225···電感性元件 545···機械連桿介面 1235…充電接觸部 551，552,553,554,556,557 …有 1615…充電基底 限重覆使用總成介面連接器 1705，1710，1715，1720，1725, 555…總成 1730…步驟 572,573 …槽 1735，1740，1745，1750，1755, 581…對準銷 1760，1765…步驟 805…球關節 1805，1810，1815，1825，1830, 810…轴 1835,1840…步驟 1011…熔絲 1910，1920，1930，1940，1950, 1110…RFID標籤 1960…步驟 1120…RFID讀取器 2010,2020,2030,2040,2050, 1130…RFID介面 1215…位移感測器 2060,2070…步驟 42105,210···Needle 320...Display 110···Luer hub 330... Housing 115... Chamber 340... Limited re-use of the end of the assembly 120, 415···Plunger 405...Distribution chamber 125,417...Plunger shaft 420...Column Plug interface 130··· thumb finger holder 425... delivery chamber housing 205···tip section 430...selective luer 215···tip section housing 444...power source controller 250··· Finite Repetitive Use Assembly 450... Temperature Control Device 255···Limited Repeated Use Assembly Housing 451, 452, 453, 454, 455, 456 ... Tip 260... Threaded Partial End Interface Connector 265, 471... Locking Mechanism 460... Thermal Sensor 270... Switch 461, 462, 463, 517, 530, 535 ~ interface 275... optional lighting 472, 473 · · · 305 ... controller 481 ... alignment slot 306, 307 ... indicator 505 ... power source 308 ... button 510 ... actuator shaft 41 200824662 515 · · · actuation 1225···inductive element 545···mechanical link interface 1235...charge contact 551,552,553,554,556,557 ...with 1615...charge base limited use assembly interface connector 1705,1710,1715,1720,1725, 555 ...assembly 1 730...Steps 572, 573 ... slots 1735, 1740, 1745, 1750, 1755, 581... Alignment pins 1760, 1765... Step 805... Ball joints 1805, 1810, 1815, 1825, 1830, 810... Axis 1835, 1840... Step 1011... Fuse 1910, 1920, 1930, 1940, 1950, 1110... RFID tag 1960... Step 1120... RFID reader 2010, 2020, 2030, 2040, 2050, 1130... RFID interface 1215... Displacement sensor 2060, 2070... steps 42

Claims (1)

200824662 十、申請專利範圍： 1. 一種用於一眼用手件之有限重覆使用總成，包含： 一致動器，其具有一軸； 一功率源，其用於將功率提供至該致動器； 一控制器，其用於控制該致動器； 一機械連桿介面，其耦合至該轴，該機械連桿介面 在一端上具有一對接表面；及 一殼體，其至少部份地包圍該功率源、該控制器、 及該致動器； 其中該有限重覆使用總成可附接至及移除自一可 拋棄式注射裝置。 2. 如申請專利範圍第1項之總成，進一步包含·· 一對的介面連接器，其設置於該有限重覆使用總成 的一介面表面上。 3. 如申請專利範圍第2項之總成，其中該對的介面連接器 將功率提供至一梢端分段。 4. 如申請專利範圍第2項之總成，其中該對的介面連接器 將功率提供至一溫度控制裝置。 5. 如申請專利範圍第2項之總成，其中該對的介面連接器 將該控制器連接至一熱感測器。 6. 如申請專利範圍第2項之總成，其中該對的介面連接器 將該控制器連接至一記憶體裝置。 7. 如申請專利範圍第6項之總成，其中有關一梢端分段的 一狀況之資料經由該對的介面連接器被轉移至該控制 43 200824662 器。 8.如申請專利範圍第6項之總成，其中劑量資料經由該對 的介面連接器被轉移至該控制器。 9·如申請專利範圍第8項之總成，其中使用該劑量資料以 控制該致動器。 10.如申請專利範圍第6項之總成，其中溫度資料經由該對 的介面連接器被轉移至該控制器。 11·如申請專利範圍第10項之總成，其中使用該溫度資料以 控制一溫度控制裝置。 12. 如申請專利範圍第1項之總成，進一步包含： 一動彈不得感測器，其用於偵测該致動器是否經歷 一動彈不得狀況；及 一介面，其用於將該動彈不得感測器連接至該控制 器。 13. 如申請專利範圍第1項之總成，進一步包含： - 一位移感測器，其用於測量該致動器軸移行的一距 離；及 一介面，其用於將該位移感測器連接至該控制器。 14 ·如申請專利範圍第1項之總成，其中該功率源為一電池。 15. 如申請專利範圍第1項之總成，其中該致動器為一步進 馬達。 16. 如申請專利範圍第1項之總成，其中該致動器為一彈簧 驅動式機構。 17. 如申請專利範圍第1項之總成，其中該致動器轴剛性地 44 200824662 連接至該機械連桿介面。 18. 如申請專利範圍第1項之總成，其中該致動器軸經由一 球及插座關節被耦合至該機械連桿介面。 19. 如申請專利範圍第1項之總成，進一步包含： 一功率源控制器，其用於監测該功率源之一狀況。 20. 如申請專利範圍第‘1項之總成，進一步包含： 電接觸部，其設置於該有限重覆使用總成的一底表 面上，該等電接觸部用於與一充電基底形成介面。 21. 如申請專利範圍第20項之總成，其中該等電接觸部為一 電子類型介面。 22. 如申請專利範圍第1項之總成，進一步包含： 一電感性元件，其設置為接近該有限重覆使用總成 的一底表面，該電感性元件用於與一充電基底形成介 面。 23·如申請專利範圍第1項之總成，進一步包含： 一RHD讀取器，其設置於該殼體中，該RFID讀取 器適可自一RFID標籤讀取資訊。 2屯如申請專利範圍第1項之總成，其中該控制器決定移動 該致動器軸及該機械連桿介面以輸送一劑量的一物質 之一距離。 25. 如申請專利範圍第1項之總成，其中該控制器操作該致 動器以使該致動器軸以一固定速率移動。 26. 如申請專利範圍第1項之總成，其中該控制器操作該致 動器以使該致動器軸以一可變速率移動。 45 200824662 27.如申請專利範圍第1項之總成，進-步包含： 其《又置於該殼體上’該指不器用於提供 有關該有限重覆使用總成的一狀態之資訊。 %如中請專利範圍第27項之總成，其中該指示器為一顯示 ‘ 種用於目艮用手件之有限重覆使用總成 ’包含： ， -致動器，其具有一軸； n 一功率源’其用於將功率提供至該致動器； 一控制器’其用於控制該致動器； 一機械連桿介面，其耦合至該軸，該機械連桿介面 在一端上具有一對接表面； - 一對的介面連接器，其設置於該有限重覆使用總成 的一介面表面上； 一位移感測裔，其用於測量該致動器軸移行的一距 離； • 一介面，其用於將該位移感测器連接至該控制、器； • 一殼體，其至少部份地包圍該功率源、該控制器、 及該致動器；及 -指7TT器’其設置於該殼體上，該指示器用於提供 有關該有限重覆使用總成的一狀態之資訊， 其中該控制器控制該致動器的操作以使該致動器 驅動該致動器轴以將一劑量的一物質輪送至一眼中。 30.如申請專利範圍第29項之總成，其中該對的介面連接器 將功率提供至一梢端分段。 46 200824662 31. 如申請專利範圍第29項之總成，其中該對的介面連接器 將該控制器連接至一熱感測器。 32. 如申請專利範圍第29項之總成，其中該對的介面連接器 將該控制器連接至一記憶體裝置。 33. 如申請專利範圍第32項之總成，其中有關一梢端分段的 一狀況之資料經由該對的介面連接器被轉移至該控制 34. 如申請專利範圍第32項之總成，其中劑量資料經由該對 的介面連接器被轉移至該控制器。 35. 如申請專利範圍第34項之總成，其中使用該劑量資料以 控制該致動器。 36. 如申請專利範圍第29項之總成，其中溫度資料經由該對 的介面連接器被轉移至該控制器。 37. 如申請專利範圍第36項之總成，其中使用該溫度資料以 控制一溫度控制裝置。 38. 如申請專利範圍第29項之總成，進一步包含： 一動彈不得感測器，其用於偵測該致動器是否經歷 一動彈不得狀況；及 一介面，其用於將該動彈不得感測器連接至該控制 器。 39. 如申請專利範圍第29項之總成，其中該功率源為一電 40. 如申請專利範圍第29項之總成，其中該致動器選自由一 步進馬達、一DC馬達、一具有一耦合至一線性傳動器 47 200824662 的旋轉感測器之DC馬達、及一具有一線性感測器的耦 合至一線性傳動器之DC馬達所組成的群組。 41. 如申請專利範圍第29項之總成，其中該致動器為一彈簧 驅動式機構。 42. 如申請專利範圍第29項之總成，其中該致動器軸剛性地 連接至該機械連桿介面。 43. 如申請專利範圍第29項之總成，其中該致動器軸經由一 球及插座關節被連接至該機械連桿介面。 44. 如申請專利範圍第29項之總成，進一步包含·· 一RFID讀取器，其設置於該殼體中，該RFID讀取 器適可自一 RF1D標籤讀取資訊。 45. 如申請專利範圍第29項之總成，其中該控制器操作該致 動器以使該致動器軸以一固定速率移動。 46. 如申請專利範圍第29項之總成，其中該控制器操作該致 動器以使該致動器軸以一可變速率移動。 47. 如申請專利範圍第29項之總成，其中該指示器為一顯示 器。 48200824662 X. Patent Application Range: 1. A limited repetitive use assembly for a one-handed hand piece, comprising: an actuator having a shaft; a power source for supplying power to the actuator; a controller for controlling the actuator; a mechanical linkage interface coupled to the shaft, the mechanical linkage interface having a mating surface on one end; and a housing at least partially surrounding the A power source, the controller, and the actuator; wherein the limited repetitive use assembly is attachable to and removable from a disposable injection device. 2. The assembly of claim 1, further comprising: a pair of interface connectors disposed on an interface surface of the finite overlap assembly. 3. The assembly of claim 2, wherein the pair of interface connectors provide power to a tip segment. 4. The assembly of claim 2, wherein the pair of interface connectors provide power to a temperature control device. 5. The assembly of claim 2, wherein the pair of interface connectors connect the controller to a thermal sensor. 6. The assembly of claim 2, wherein the pair of interface connectors connect the controller to a memory device. 7. The assembly of claim 6, wherein the information about a condition of the tip segment is transferred to the control via the pair of interface connectors. 8. The assembly of claim 6, wherein the dosage data is transferred to the controller via the pair of interface connectors. 9. The assembly of claim 8 wherein the dosage data is used to control the actuator. 10. The assembly of claim 6, wherein the temperature data is transferred to the controller via the pair of interface connectors. 11. The assembly of claim 10, wherein the temperature data is used to control a temperature control device. 12. If the assembly of claim 1 of the patent scope further comprises: a moving missile, the sensor is not used to detect whether the actuator is subjected to a moving state; and an interface is used for the moving missile A sensor is connected to the controller. 13. The assembly of claim 1, further comprising: - a displacement sensor for measuring a distance traveled by the actuator shaft; and an interface for the displacement sensor Connect to the controller. 14) The assembly of claim 1, wherein the power source is a battery. 15. The assembly of claim 1, wherein the actuator is a stepper motor. 16. The assembly of claim 1, wherein the actuator is a spring-driven mechanism. 17. The assembly of claim 1, wherein the actuator shaft is rigidly connected to the mechanical linkage interface 44 200824662. 18. The assembly of claim 1, wherein the actuator shaft is coupled to the mechanical linkage interface via a ball and socket joint. 19. The assembly of claim 1, further comprising: a power source controller for monitoring a condition of the power source. 20. The assembly of claim '1, further comprising: an electrical contact disposed on a bottom surface of the finite overlap assembly, the electrical contacts being configured to form an interface with a charging substrate . 21. The assembly of claim 20, wherein the electrical contacts are an electronic type interface. 22. The assembly of claim 1, further comprising: an inductive component disposed proximate to a bottom surface of the finite overlap assembly, the inductive component for forming a interface with a charging substrate. 23. The assembly of claim 1, further comprising: an RHD reader disposed in the housing, the RFID reader adapted to read information from an RFID tag. 2. The assembly of claim 1, wherein the controller determines to move the actuator shaft and the mechanical linkage interface to deliver a dose of a substance. 25. The assembly of claim 1, wherein the controller operates the actuator to move the actuator shaft at a fixed rate. 26. The assembly of claim 1, wherein the controller operates the actuator to move the actuator shaft at a variable rate. 45 200824662 27. The assembly of claim 1, wherein the step further comprises: "on the housing again" the finger is used to provide information about a state of the limited reuse assembly. %, as in the assembly of claim 27 of the patent scope, wherein the indicator is a display "a limited reuse assembly for witnessing the hand piece" includes: - an actuator having an axis; a power source 'which is used to provide power to the actuator; a controller' for controlling the actuator; a mechanical linkage interface coupled to the shaft, the mechanical linkage interface having on one end a pair of interface surfaces; - a pair of interface connectors disposed on an interface surface of the finite overlap assembly; a displacement sensing body for measuring a distance of movement of the actuator shaft; An interface for connecting the displacement sensor to the control; a housing that at least partially surrounds the power source, the controller, and the actuator; and - refers to a 7TT device Provided on the housing, the indicator is for providing information about a state of the limited reuse assembly, wherein the controller controls operation of the actuator to cause the actuator to drive the actuator shaft A dose of one substance is delivered to one eye. 30. The assembly of claim 29, wherein the pair of interface connectors provide power to a tip segment. 46 200824662 31. The assembly of claim 29, wherein the pair of interface connectors connect the controller to a thermal sensor. 32. The assembly of claim 29, wherein the pair of interface connectors connect the controller to a memory device. 33. The assembly of claim 32, wherein the information relating to a condition of the tip segment is transferred to the control via the pair of interface connectors. 34. The assembly of claim 32, The dose data is transferred to the controller via the pair of interface connectors. 35. The assembly of claim 34, wherein the dosage data is used to control the actuator. 36. The assembly of claim 29, wherein the temperature data is transferred to the controller via the pair of interface connectors. 37. The assembly of claim 36, wherein the temperature data is used to control a temperature control device. 38. The assembly of claim 29, further comprising: a moving missile sensor for detecting whether the actuator is subjected to a moving state; and an interface for not A sensor is connected to the controller. 39. The assembly of claim 29, wherein the power source is an electric 40. The assembly of claim 29, wherein the actuator is selected from the group consisting of a stepper motor, a DC motor, and a A group of DC motors coupled to a rotary actuator of a linear actuator 47 200824662, and a DC motor coupled to a linear actuator having a line of sensors. 41. The assembly of claim 29, wherein the actuator is a spring-driven mechanism. 42. The assembly of claim 29, wherein the actuator shaft is rigidly coupled to the mechanical linkage interface. 43. The assembly of claim 29, wherein the actuator shaft is coupled to the mechanical linkage interface via a ball and socket joint. 44. The assembly of claim 29, further comprising: an RFID reader disposed in the housing, the RFID reader being adapted to read information from an RF1D tag. 45. The assembly of claim 29, wherein the controller operates the actuator to move the actuator shaft at a fixed rate. 46. The assembly of claim 29, wherein the controller operates the actuator to move the actuator shaft at a variable rate. 47. The assembly of claim 29, wherein the indicator is a display. 48
TW096138456A 2006-10-16 2007-10-15 Limited reuse assembly for ophthalmic injection device TW200824662A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92149806P 2006-10-16 2006-10-16
US92149706P 2006-10-16 2006-10-16
US92149906P 2006-10-16 2006-10-16
US11/832,364 US20070270744A1 (en) 2006-05-17 2007-08-01 Limited Reuse Assembly For Ophthalmic Injection Device

Publications (1)

Publication Number Publication Date
TW200824662A true TW200824662A (en) 2008-06-16

Family

ID=44771591

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096138456A TW200824662A (en) 2006-10-16 2007-10-15 Limited reuse assembly for ophthalmic injection device

Country Status (2)

Country Link
TW (1) TW200824662A (en)
WO (1) WO2008140546A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107920892A (en) * 2015-09-16 2018-04-17 诺华股份有限公司 For being inserted into the hydraulic injector and method of intraocular lens

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017430A2 (en) * 2008-08-08 2010-02-11 Mallinckrodt Inc. Automatic injector ram homing
JP6038124B2 (en) 2011-05-06 2016-12-07 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Lockout members with different cross sections
GB201718271D0 (en) * 2017-11-03 2017-12-20 Surgical Dynamics Ltd Obstetric Forceps
EP3710089A1 (en) * 2017-11-16 2020-09-23 Amgen Inc. Autoinjector with stall and end point detection
WO2019162222A1 (en) * 2018-02-26 2019-08-29 Haselmeier Ag Dosage determination using electrical conductivity in an injection device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066276A (en) * 1988-06-21 1991-11-19 Alcon Laboratories, Inc. Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control
CA2129284C (en) * 1993-11-24 1999-03-09 Kenneth J. Niehoff Controlling plunger drives for fluid injection in animals
US5733256A (en) * 1996-09-26 1998-03-31 Micro Medical Devices Integrated phacoemulsification system
DE69913344T2 (en) * 1998-06-15 2004-10-14 Medrad, Inc. CODING SYRINGE INFORMATION
US6595979B1 (en) * 2001-07-10 2003-07-22 Myocardial Therapeutics, Inc. Methods for sterile aspiration/reinjection of bodily fluid
US7507221B2 (en) * 2004-10-13 2009-03-24 Mallinckrodt Inc. Powerhead of a power injection system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107920892A (en) * 2015-09-16 2018-04-17 诺华股份有限公司 For being inserted into the hydraulic injector and method of intraocular lens

Also Published As

Publication number Publication date
WO2008140546A8 (en) 2010-07-22
WO2008140546A3 (en) 2009-07-23
WO2008140546A2 (en) 2008-11-20

Similar Documents

Publication Publication Date Title
US7871399B2 (en) Disposable ophthalmic injection device
US7887521B2 (en) Ophthalmic injection system
CA2663524C (en) Battery operated ophthalmic hand piece with disposable end
JP2010535039A (en) Disposable ophthalmic injection device
EP2063829B1 (en) Universal rechargeable limited reuse assembly for ophthalmic hand piece
TW200824662A (en) Limited reuse assembly for ophthalmic injection device
US20100106083A1 (en) Method of Operating Ophthalmic Hand Piece with Disposable End
CA2665172C (en) Disposable ophthalmic injection device
TW200826908A (en) Disposable ophthalmic injection device
JP2010535040A (en) Limited reuse assembly for ophthalmic injection devices
TW200824739A (en) Ophthalmic injection method
TW200824664A (en) Ophthalmic injection system
EP2068792A2 (en) Limited reuse assembly for ophthalmic injection device