TW200633717A - Process for and intermediates in the preparation of canfosfamide and its salts, pharmaceutical compositions containing some intermediates, and their use as anticancer agents - Google Patents

Process for and intermediates in the preparation of canfosfamide and its salts, pharmaceutical compositions containing some intermediates, and their use as anticancer agents

Info

Publication number: TW200633717A
Authority: TW; Taiwan
Prior art keywords: intermediates; canfosfamide; salts; preparation; pharmaceutical compositions
Prior art date: 2004-12-21

Application number

TW094141102A

Other languages

English (en)

Inventor

William A Boulanger

Steven J Collier

Stephen A Eastham

Dennis L Edie

Ronan Y Guevel

Abad Pedro E Hernandez

R Jason Herr

Hans J Kjaersgaard

Harold Meckler

Robert E Polomski

Steven R Schow

Pavel E Zhichkin

Original Assignee

Telik Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-21

Filing date

2005-11-23

Publication date

2006-10-01

2005-11-23 Application filed by Telik Inc filed Critical Telik Inc

2006-10-01 Publication of TW200633717A publication Critical patent/TW200633717A/zh

Links

239000000543 intermediate Substances 0.000 title abstract 4
239000002246 antineoplastic agent Substances 0.000 title abstract 2
OJLHWPALWODJPQ-QNWVGRARSA-N canfosfamide Chemical compound ClCCN(CCCl)P(=O)(N(CCCl)CCCl)OCCS(=O)(=O)C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)N[C@@H](C(O)=O)C1=CC=CC=C1 OJLHWPALWODJPQ-QNWVGRARSA-N 0.000 title abstract 2
229950000772 canfosfamide Drugs 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

TW094141102A 2004-12-21 2005-11-23 Process for and intermediates in the preparation of canfosfamide and its salts, pharmaceutical compositions containing some intermediates, and their use as anticancer agents TW200633717A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11/018,391 US8198247B2 (en)	2004-12-21	2004-12-21	Process for and intermediates in the preparation of canfosfamide and its salts

Publications (1)

Publication Number	Publication Date
TW200633717A true TW200633717A (en)	2006-10-01

Family

ID=36216909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW094141102A TW200633717A (en)	2004-12-21	2005-11-23	Process for and intermediates in the preparation of canfosfamide and its salts, pharmaceutical compositions containing some intermediates, and their use as anticancer agents

Country Status (15)

Country	Link
US (2)	US8198247B2 (zh)
EP (1)	EP1827605B1 (zh)
JP (1)	JP5060306B2 (zh)
KR (1)	KR20070089795A (zh)
CN (1)	CN101080251B (zh)
AR (1)	AR052167A1 (zh)
AU (1)	AU2005319579B2 (zh)
BR (1)	BRPI0519141A2 (zh)
CA (1)	CA2587088A1 (zh)
EA (1)	EA016052B1 (zh)
IL (1)	IL182835A0 (zh)
MX (1)	MX2007007215A (zh)
TW (1)	TW200633717A (zh)
WO (1)	WO2006068769A1 (zh)
ZA (1)	ZA200704318B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4521488B2 (ja) *	2008-08-21	2010-08-11	福美森重	線維筋痛症候群の治療剤並びに筋攣縮による疼痛の治療剤
US8324426B2 (en)	2008-08-28	2012-12-04	Telik, Inc.	Formulations of canfosfamide and their preparation
US20100056825A1 (en) *	2008-08-28	2010-03-04	Telik, Inc.	Formulations of canfosfamide and their preparation
CA2733732A1 (en) *	2011-02-25	2012-08-25	Telik, Inc.	Formulations of canfosfamide and their preparation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5556942A (en) *	1991-04-29	1996-09-17	Terrapin Technologies, Inc.	Glutathione S-transferase-activated compounds
US6627732B1 (en) *	1998-04-16	2003-09-30	Teijin Limited	Glutathione derivatives and their dosage forms
US6417397B1 (en) *	1999-10-04	2002-07-09	The Regents Of The University Of California, San Diego	N-substituted alkylamino acids for use as amino-protecting groups
UA74574C2 (en)	2000-05-02	2006-01-16	Telik Inc	Bis (n,n'-bis(2-halogenethyl)amino)phosphodiamates, a method for producing thereof (variants), a pharmaceutical composition containing them, and a method for the treatment of tumors
US6506739B1 (en)	2001-05-01	2003-01-14	Telik, Inc.	Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
DE602006003064D1 (en) *	2005-01-06	2008-11-20	Telik Inc	Tripeptid- und tetrapeptid-thioether

2004
- 2004-12-21 US US11/018,391 patent/US8198247B2/en not_active Expired - Fee Related
2005
- 2005-11-23 CA CA002587088A patent/CA2587088A1/en not_active Abandoned
- 2005-11-23 MX MX2007007215A patent/MX2007007215A/es active IP Right Grant
- 2005-11-23 KR KR1020077012351A patent/KR20070089795A/ko active IP Right Grant
- 2005-11-23 WO PCT/US2005/042693 patent/WO2006068769A1/en active Application Filing
- 2005-11-23 CN CN2005800428600A patent/CN101080251B/zh not_active Expired - Fee Related
- 2005-11-23 AU AU2005319579A patent/AU2005319579B2/en not_active Ceased
- 2005-11-23 EP EP05852166.7A patent/EP1827605B1/en active Active
- 2005-11-23 TW TW094141102A patent/TW200633717A/zh unknown
- 2005-11-23 BR BRPI0519141-6A patent/BRPI0519141A2/pt not_active IP Right Cessation
- 2005-11-23 JP JP2007548240A patent/JP5060306B2/ja not_active Expired - Fee Related
- 2005-11-23 EA EA200701180A patent/EA016052B1/ru not_active IP Right Cessation
- 2005-12-15 AR ARP050105289A patent/AR052167A1/es not_active Application Discontinuation
2007
- 2007-04-26 IL IL182835A patent/IL182835A0/en unknown
- 2007-05-25 ZA ZA200704318A patent/ZA200704318B/xx unknown
2012
- 2012-03-23 US US13/429,065 patent/US8334266B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20060135409A1 (en)	2006-06-22
CA2587088A1 (en)	2006-06-29
AU2005319579B2 (en)	2011-07-21
JP2008524327A (ja)	2008-07-10
EA016052B1 (ru)	2012-01-30
AU2005319579A1 (en)	2006-06-29
JP5060306B2 (ja)	2012-10-31
US8198247B2 (en)	2012-06-12
WO2006068769A1 (en)	2006-06-29
ZA200704318B (en)	2008-09-25
BRPI0519141A2 (pt)	2008-12-30
AR052167A1 (es)	2007-03-07
MX2007007215A (es)	2007-08-14
US20120238772A1 (en)	2012-09-20
EP1827605A1 (en)	2007-09-05
EP1827605B1 (en)	2014-03-26
CN101080251B (zh)	2012-08-29
IL182835A0 (en)	2007-08-19
US8334266B2 (en)	2012-12-18
EA200701180A1 (ru)	2008-04-28
KR20070089795A (ko)	2007-09-03
CN101080251A (zh)	2007-11-28

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