TW200616983A - Method for preparation of diarylisoxazole sulfonamide compounds and intermediates - Google Patents

Method for preparation of diarylisoxazole sulfonamide compounds and intermediates

Info

Publication number
TW200616983A
TW200616983A TW094119537A TW94119537A TW200616983A TW 200616983 A TW200616983 A TW 200616983A TW 094119537 A TW094119537 A TW 094119537A TW 94119537 A TW94119537 A TW 94119537A TW 200616983 A TW200616983 A TW 200616983A
Authority
TW
Taiwan
Prior art keywords
compound
diarylisoxazole
diaryl
diarylenamine
contacting
Prior art date
Application number
TW094119537A
Other languages
Chinese (zh)
Inventor
Leo J Letendre
Cynthia K Snoddy
George H Klemm
Jon P Lawson
Michael J Bauer
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of TW200616983A publication Critical patent/TW200616983A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The disclosure provides a method for the preparation of a diarylisoxazole sulfonamide compound comprising contacting a deoxybenzoin with a secondary amine to form a diarylenamine compound; contacting the diarylenamine compound with an acetylating agent to form an acetyl diarylenamine compound; contacting the acetyl diarylenamine compound with a source of hydroxylamine to form an diaryl isoxazolol compound; eliminating water from the diaryl isoxazolol compound to form a diaryl isoxazole compound, chlorosulfonating the diarylisoxazole compound to form a chlorosulfonyl diaryl isoxazole compound; and contacting the chlorosulfonyl diaryl isoxazole compound with a source of ammonia to form the diarylisoxazole sulfonamide compound.
TW094119537A 2004-06-14 2005-06-13 Method for preparation of diarylisoxazole sulfonamide compounds and intermediates TW200616983A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57959104P 2004-06-14 2004-06-14

Publications (1)

Publication Number Publication Date
TW200616983A true TW200616983A (en) 2006-06-01

Family

ID=34972271

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094119537A TW200616983A (en) 2004-06-14 2005-06-13 Method for preparation of diarylisoxazole sulfonamide compounds and intermediates

Country Status (3)

Country Link
AR (1) AR049301A1 (en)
TW (1) TW200616983A (en)
WO (1) WO2005123701A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103172583A (en) * 2013-03-07 2013-06-26 深圳市资福药业有限公司 Parecoxib preparation method
CN104250232A (en) * 2013-06-26 2014-12-31 四川唯拓生物医药有限公司 Preparation method of parecoxib sodium
CN104447600B (en) * 2013-09-22 2016-03-30 江苏奥赛康药业股份有限公司 A kind of Preparation Method And Their Intermediate impurity of Parecoxib sodium compound, preparation method and application
CN105085425B (en) * 2014-05-23 2018-01-30 昆药集团股份有限公司 A kind of method for preparing SC 69124
CN104193694B (en) * 2014-09-19 2016-08-24 成都欣捷高新技术开发有限公司 A kind of method preparing Parecoxib Sodium intermediate
CN105801508B (en) * 2014-12-30 2018-12-11 上海鼎雅药物化学科技有限公司 The preparation method of SC 69124
CN106146424A (en) * 2015-03-23 2016-11-23 上海医药工业研究院 A kind of preparation method of 5-methyl-3,4-diphenyl isoxazole
CN105418528B (en) * 2015-12-31 2018-08-24 山东罗欣药业集团股份有限公司 A kind of preparation method of Parecoxib Sodium
CN106008388B (en) * 2016-05-25 2018-06-26 吴兴龙 A kind of preparation method for the SC 69124 for being used to treat postoperative pain
CN106008386B (en) * 2016-05-25 2018-11-06 台州宝诚科技服务有限公司 A method of preparing the SC 69124 for treating postoperative pain
CN110305071A (en) * 2019-07-23 2019-10-08 成都通德药业有限公司 A kind of synthetic method of Parecoxib Sodium intermediate SC 69124
CN110790745A (en) * 2019-11-12 2020-02-14 青岛科技大学 Preparation method for extracting vitacoxib from waste tablets
CN111153866A (en) * 2020-01-19 2020-05-15 上海臣邦医药科技股份有限公司 Parecoxib sodium disubstituted impurity and preparation method and application thereof
CN111153865A (en) * 2020-01-19 2020-05-15 上海臣邦医药科技股份有限公司 Parecoxib sodium substituted impurity and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2212836C (en) * 1995-02-13 2003-08-12 G.D. Searle & Co. Substituted isoxazoles for the treatment of inflammation
US6673818B2 (en) * 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation

Also Published As

Publication number Publication date
WO2005123701A1 (en) 2005-12-29
AR049301A1 (en) 2006-07-12

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