TW200608968A - Tetrasubstituted imidazole derivatives as cannabinoid cb1 receptor modulators with a high cb1/cb2 receptor subtype selectivity - Google Patents

Tetrasubstituted imidazole derivatives as cannabinoid cb1 receptor modulators with a high cb1/cb2 receptor subtype selectivity

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Publication number
TW200608968A
TW200608968A TW094116864A TW94116864A TW200608968A TW 200608968 A TW200608968 A TW 200608968A TW 094116864 A TW094116864 A TW 094116864A TW 94116864 A TW94116864 A TW 94116864A TW 200608968 A TW200608968 A TW 200608968A
Authority
TW
Taiwan
Prior art keywords
receptor
art
relates
imidazole derivatives
disclosed
Prior art date
Application number
TW094116864A
Other languages
Chinese (zh)
Inventor
Josephus H M Lange
Hendrik C Wals
Cornelis G Kruse
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of TW200608968A publication Critical patent/TW200608968A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to 1,2,4,5-tetrasubstituted imidazole derivatives as selective cannabinoid CB1 receptor modulators, in particular CB1 receptor antagonists or inverse agonists having a high CB1/CB2 receptor subtype selectivity, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said imidazole derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of psychiatric and neurological disorders. The compounds have the general formula (1), , wherein the symbols have the meanings given in the specification.
TW094116864A 2004-05-28 2005-05-24 Tetrasubstituted imidazole derivatives as cannabinoid cb1 receptor modulators with a high cb1/cb2 receptor subtype selectivity TW200608968A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04076619 2004-05-28

Publications (1)

Publication Number Publication Date
TW200608968A true TW200608968A (en) 2006-03-16

Family

ID=34928258

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094116864A TW200608968A (en) 2004-05-28 2005-05-24 Tetrasubstituted imidazole derivatives as cannabinoid cb1 receptor modulators with a high cb1/cb2 receptor subtype selectivity

Country Status (5)

Country Link
CN (1) CN1956965B (en)
AR (1) AR052763A1 (en)
SA (1) SA05260148B1 (en)
TW (1) TW200608968A (en)
UA (1) UA85239C2 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI231757B (en) * 2001-09-21 2005-05-01 Solvay Pharm Bv 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity

Also Published As

Publication number Publication date
UA85239C2 (en) 2009-01-12
CN1956965A (en) 2007-05-02
SA05260148B1 (en) 2008-11-15
AR052763A1 (en) 2007-04-04
CN1956965B (en) 2011-03-23

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