TW200533758A - Methods of diagnosis - Google Patents

Methods of diagnosis Download PDF

Info

Publication number
TW200533758A
TW200533758A TW094101217A TW94101217A TW200533758A TW 200533758 A TW200533758 A TW 200533758A TW 094101217 A TW094101217 A TW 094101217A TW 94101217 A TW94101217 A TW 94101217A TW 200533758 A TW200533758 A TW 200533758A
Authority
TW
Taiwan
Prior art keywords
u95av2
protein
doc
cells
tissue
Prior art date
Application number
TW094101217A
Other languages
Chinese (zh)
Inventor
Steven Kevin Smith
David Stephen Charnock-Jones
Cristin Gregor Print
Nicola Anne Johnson
Original Assignee
Univ Cambridge Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cambridge Tech filed Critical Univ Cambridge Tech
Publication of TW200533758A publication Critical patent/TW200533758A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)

Abstract

The invention provides methods of assessing a tissue inflammatory response, comprising making a quantitative determination of the level of at least five transcripts shown in Table 1, or proteins encoded thereby, in a sample; and comparing the abundance of said transcripts or proteins so determined with the level of said transcript obtained from a control sample. Methods for diagnosis of a condition with which a tissue inflammatory response is associated are also provided, as are gene chip arrays and protein based assays suitable for use in these methods. Assay methods for determining a modulator of a tissue inflammatory response or a condition associated therewith also form part of the invention.

Description

200533758 九、發明說明： 【發明所屬之技術領域】 本發明係關於内皮細胞的基因表現輪廓，以及使用這些 輪廓來評估疾病狀況與治療。 — 【先前技術】 白血球移動至組織内’是免疫系統、黏膜表面、子宮内 膜、乳腺和卵巢之正常功能的關鍵部分。然而，亦可藉著 炎症反應刺激白血球從血管内空間移居到組織内。炎=是 • 纟體對損傷或感染的反應’且通常涉及白血球和蛋白質移 動越過内皮壁並進入組織内。 炎症反應涉及各種發送信號的分子。其中一些作用在内 皮上，引起内皮細胞互相黏附得較不緊密，並/或使其表 面有黏性，使白血球細胞通過。其他信號的作用為白血球 的化學吸引劑，或促進在白血球上之黏連分子的表現。其 他的信號則調節白血球激活和存活。 發送信號的分子包括，快釋放，的介體，其涉及增加血管 • 通透性，如組織胺。這些與晚期之，過程誘發，的介體以協 同方式產生作用。晚期的介體包括化學激動劑，其吸引白 血球至炎症區域内’以及隨後從炎症細胞中釋放並激活内 皮細胞的細胞激動素。 TNF-α、IL-1/3和IL-8是在炎症部位以高濃度發現的炎症 介體，而内皮細胞加工處理這些介體的受體（1-3)。 TNF-α疋原型的細胞激動素，最初從巨嗟細胞中分離出 來，但現在已知是由各種細胞產生，包括淋巴細胞、單核 98677.doc 200533758 細胞、嗜中性白血球、τ-細胞、肌細胞和平滑肌細胞。被 TNFw吸引的TNF受體1，在各種細胞類型中導致細胞凋零 的發動。受體結合結果亦支持Νια之激活作用，為表現 涉及炎症反應，以及增加細胞存活和提高對TNF- α _誘導 之細胞凋零的抵抗力之基因節目所需要的。在内皮細胞中 亦藉著TNF-α激活發送信號之路徑，包括磷脂醯肌醇（ρι) 激酶依賴性激酶、緊迫激活之蛋白質激酶（SApK)和促細胞 ***劑激活之蛋白質激酶（MAPK)(3, 4)。 IL-1/5是另一個原型的細胞激動素。分泌^―丨卢的主要來 源是單核細胞，但其亦由各種其他的細胞類型產生，特別 包括激活之巨噬細胞、嗜中性白血球、血小板、孓和&細 胞、天然殺手（NK)細胞、内皮細胞、sMCs(平滑肌細胞）和 纖維母細胞。IL-1/5以前驅物之形式合成，而一旦經蛋白 水解作用切開，便可激活許多在免疫力和炎症中扮演某種 角色的細胞類型。像TNF-α —樣，IL-1/5激活NF-κΒ(核因 子κΒ)存活路徑，以及MAPK階梯p42/p44、p38和Jnk(5)。 IL_8是已經與血管生成密切連接的化學激動素。IL_8的 要末源疋皁核細胞、嗜中性白血球、丁_細胞、Νκ細胞、 内皮細胞、纖維母細胞和上皮細胞。IL-8涉及白血球移動 至組織内的過程，以及炎症反應的其他方面。它的產製不 疋組成上的，而是藉著前-炎症細胞激動素來誘導。IL-8與 肝素結合，並在活體外誘導内皮細胞移動、增殖和存活 (6) ° IL-8與其受體似乎在血管生成和腫瘤進展上是關鍵性 的（75 8)。 98677.doc 200533758 炎症的分子介體，如TNF- α、IL-1和IL-8，作用在發炎 組織的標革巴細胞上，如内皮細胞、纖維母細胞和白血球。 炎症介體’如這三種的混合影響是協同的-即這些因子，一 起作用’可能與它們個別影響的總和不同。 組織的炎症反應，如在炎症疾病中代表性的，通常涉及 白血球和蛋白質異常或過量的移動至組織内。這可導致很 夕心丨生或性的炎症病症。白企球和蛋白質移動亦可在不 是原發性炎症疾病，但其中組織證實有炎症反應的狀況中 扮演某種角色。例如，動脈粥樣硬化和子宮内膜異位症之 疾病，可能依賴白血球移動至病變内。出現在猝發或心臟 病發作中的組織壞死修補，亦需要炎症反應。可由白血球 調節腫瘤生長，其從血液移動至腫瘤内。這些白血球釋放 因子直接促進腫瘤細胞生長和腫瘤血管生成。此外，白血 球移動至腫瘤内，調解對腫瘤細胞-專一之抗原的免疫反 應，具有後續的抗-腫瘤效果。因此，炎症反應在腫瘤生 長中的角色是複雜的，並涉及在刺激與抑制路徑之間的平 衡。 由於炎症反應在各種病理學狀況中的角色，對於發展評 估或治療與這類反應有關之人類醫學狀況的方法有持續的 需求。此外，炎症反應是像雌性生產和傷口癒合之生理學 過程的必要特徵。為了調節這些過程，需要調節炎症反應 的方法。 【發明内容】 我們已經分析了在人類臍靜脈内皮細胞（HuveCs)與 98677.doc 200533758 TNF-α、介白素_1/3和介白素-8之混合物接觸時發生的轉 譯本富含量上的變化。這些因子通常在炎症反應期間，以 增加的濃度出現在組織中，並在持續的期間内，由各種細 胞類型分泌。 測試衍生自許多不同個體之内皮細胞的原始細胞培養 物，以便獲得在炎症反應期Μ，在多個個體之内皮細胞中 調節的一組一致的轉錄本。使用生物-資訊演算法的新穎200533758 IX. Description of the invention: [Technical field to which the invention belongs] The present invention relates to the gene expression profiles of endothelial cells, and the use of these profiles to evaluate disease conditions and treatment. — [Prior art] White blood cells move into tissues' is a key part of the normal functioning of the immune system, mucosal surface, endometrium, breast and ovaries. However, it is also possible to stimulate the migration of white blood cells from the intravascular space into tissues through an inflammatory response. Inflammation = Yes • The response of the corpus callosum to injury or infection ’and usually involves the movement of white blood cells and proteins across the endothelial wall and into the tissue. The inflammatory response involves various molecules that send signals. Some of them act on the endothelium, causing endothelial cells to adhere less closely to each other, and / or making their surfaces sticky, allowing white blood cells to pass through. Other signals function as a chemical attractor of white blood cells or promote the expression of adhesion molecules on white blood cells. Other signals regulate white blood cell activation and survival. Signaling molecules include, fast-release mediators that are involved in increasing blood vessel permeability, such as histamine. These interact in a synergistic manner with the later, process-induced mediators. Advanced mediators include chemical agonists that attract white blood cells into the area of inflammation 'and subsequently release cytokinins from inflammatory cells and activate endothelial cells. TNF-α, IL-1 / 3, and IL-8 are inflammatory mediators found at high concentrations in the site of inflammation, and endothelial cells process the receptors for these mediators (1-3). The cytokine of the TNF-α 疋 prototype was originally isolated from macrophages, but it is now known to be produced by various cells, including lymphocytes, monocytes, 98677.doc 200533758 cells, neutrophils, τ-cells, Muscle cells and smooth muscle cells. The TNF receptor 1 attracted by TNFw causes the onset of cell death in various cell types. Receptor binding results also support the activation of Nια, which is required for the performance of genetic programs involving inflammatory responses, as well as increasing cell survival and increasing resistance to TNF-α-induced cell decay. Signaling pathways are also activated in endothelial cells via TNF-α, including phospholipids inositol (ρι) kinase-dependent kinase, urgently activated protein kinase (SApK), and mitogen-activated protein kinase (MAPK) ( 3, 4). IL-1 / 5 is another prototype of cytokinin. The main source of secretion is monocytes, but it is also produced by a variety of other cell types, including activated macrophages, neutrophils, platelets, 孓 and & cells, natural killer (NK) Cells, endothelial cells, sMCs (smooth muscle cells) and fibroblasts. IL-1 / 5 is synthesized as a precursor, and once proteolytically cleaved, it activates many cell types that play a role in immunity and inflammation. Like TNF-α, IL-1 / 5 activates the NF-κΒ (nuclear factor κΒ) survival pathway, as well as the MAPK ladder p42 / p44, p38, and Jnk (5). IL_8 is a chemokine that has been closely linked to angiogenesis. The main sources of IL-8 are saponin cells, neutrophils, T cells, Nk cells, endothelial cells, fibroblasts, and epithelial cells. IL-8 is involved in the process by which white blood cells move into tissues, as well as other aspects of the inflammatory response. Its production system is not composed, but is induced by pre-inflammatory cytokinins. IL-8 binds to heparin and induces endothelial cell migration, proliferation, and survival in vitro (6) ° IL-8 and its receptors appear to be critical in angiogenesis and tumor progression (75 8). 98677.doc 200533758 Inflammatory molecular mediators, such as TNF-α, IL-1, and IL-8, act on standard paraffin cells in inflamed tissues, such as endothelial cells, fibroblasts, and white blood cells. Inflammatory mediators such as these three mixed effects are synergistic-that is, these factors, once acting, may differ from the sum of their individual effects. Tissue inflammatory responses, as representative in inflammatory diseases, usually involve abnormal or excessive movement of white blood cells and proteins into the tissue. This can lead to severe or sexual inflammatory conditions. White globules and protein movement can also play a role in conditions that are not a primary inflammatory disease, but where the tissue confirms an inflammatory response. For example, diseases of atherosclerosis and endometriosis may rely on white blood cells to move into the lesion. Tissue necrosis repair, which occurs during a sudden or cardiac attack, also requires an inflammatory response. Tumor growth can be regulated by white blood cells, which move from the blood into the tumor. These white blood cell release factors directly promote tumor cell growth and tumor angiogenesis. In addition, white blood cells move into the tumor, mediating the immune response to tumor cell-specific antigens, and have subsequent anti-tumor effects. Therefore, the role of inflammatory responses in tumor growth is complex and involves a balance between stimulation and inhibition pathways. Because of the role of inflammatory responses in various pathological conditions, there is a continuing need to develop methods for assessing or treating human medical conditions associated with such reactions. In addition, the inflammatory response is an essential feature of physiological processes like female production and wound healing. To regulate these processes, methods for regulating the inflammatory response are needed. [Summary of the Invention] We have analyzed the rich content of translations that occur when human umbilical vein endothelial cells (HuveCs) come in contact with a mixture of 98677.doc 200533758 TNF-α, interleukin_1 / 3, and interleukin-8. Changes. These factors usually appear in tissues at increased concentrations during the inflammatory response and are secreted by various cell types over a sustained period. Primitive cell cultures derived from endothelial cells from many different individuals are tested to obtain a consistent set of transcripts that are regulated in the endothelial cells of multiple individuals during the inflammatory response phase M. Novel using bio-information algorithms

組成，包括經過修改的L〇ess標準化和CyberT演算法，分 析數據。 此外’我們分析了在獲自身體不同部分之不同内皮細胞 類型中的表現，即HUVEC、人類冠狀動脈内皮細胞 (HCAEC)和人類子宮微▲管内皮細胞⑼。發現許 多轉錄^ ’包括在鑛奶中最強調節的那些，—致地由 在所有這三種細胞類型中的炎症信號調節。 ^ ^在本毛明中，我們已經使用新穎的方法學，確認 第τ間在内皮細胞反映炎症信號時，在調節某些基因表 現上的鉍化模式’以及一組—致的基因，反映在衍生自許 多個體之内皮細月舍中沾火— 勺穴症^號而修改其轉錄本，並因此 可能對患者族群有廣泛的應用性。 、因此，、本發明提供評估（例如診斷、預後或監視）組織炎 症反應或與其有關之狀況的方法。這較應通常與許多狀 況之一有關，且其亦 —— 涉及白血球跨越内皮的移動。因 此，藉著判定組織炎齐 反應，亦可進行舆該反應有關之狀 況的判疋。再者，發現 疋叶夕轉錄本在廷些反應及由此而來 98677.doc 200533758 的狀況甲叉到调節’本身已知的與得自ests之基因兩者， 容許供應新賴的測定標乾，並為這類狀況發展新的療法。 因此’在第-項觀點中，本發明提供評估組織炎症反應 的方法，包括·· 在试樣中，進行在表i中出示之至少5個轉錄本或由其編 碼之蛋白質的含量的定量判定；並 將如此#彳定之該轉錄本或蛋白質的富含量與獲自細胞之 對照組試樣的該轉錄本或蛋白質之含量相比較。 較佳的是，該試樣包括輿ό 又在μ者中咸相信受到組織炎 症反應影響之部位的細胞，適 、 ^ 週田的疋内皮細胞，或患者的 血液、血清或尿。 在另一項觀點中，本發明袒 料月耠供適用於本發明之上述方法 中的基因晶片陣列，包括在表 中所不的至少5個轉錄本； 可視而要對該轉錄本專一的對昭 丁…、、、且，以及可視需要至少一 個基因晶片的對照組。 $ &夕 在更進-步的觀點中，本發明提供以適 上述方法巾的敎為基礎之蛋自f，^ 7 = 包括在表1中出示之那些的韓 ^ 5们由 要斟兮I ώ所、.八本、，扁碼之蛋白質；可視需 要對為蛋白貝專一的對照組；以及 定的對照組。 戈主^個§亥測 在更進一步的觀點中，太菸 x月長1仏判定組織炎症及雍式 鉍其有關之狀況的抑揚,笳t f ，心或 括： I 周即劑的測定方法，其中該方法包 a)提供由得自表1之轉錄本編碼的蛋白質； 9867^.(100 -10- 200533758 性 b)使該蛋自質與其活性之候選的抑揚 C)判定該肖€的抑揚調節劑是否能夠 調節劑接觸，· 調節該蛋白質 之活 應之候選的抑揚 調節劑接The composition, including modified Loess standardization and CyberT algorithm, analyzes the data. In addition, we analyzed the performance in different endothelial cell types obtained from different parts of the body, namely HUVEC, human coronary endothelial cells (HCAEC), and human uterine microtubule endothelial cells⑼. Many transcripts were found including those that are most strongly regulated in mineral milk-caused by inflammatory signals in all three of these cell types. ^ ^ In Ben Maoming, we have used a novel methodology to confirm the bismuth pattern in regulating the expression of certain genes when the tau reflects the inflammatory signal in endothelial cells' and a set of uniform genes, which are reflected in derived from In many individuals, the endothelium in the endothelium has been modified with a schistosomiasis ^ and its transcript has been modified, and therefore it may have wide applicability to patient populations. Accordingly, the present invention provides a method for assessing (e.g., diagnosing, prognostic, or monitoring) a tissue's inflammatory response or a condition associated therewith. This should usually be related to one of many conditions, and it also involves the movement of white blood cells across the endothelium. Therefore, by judging the tissue inflammation response, it is also possible to judge the conditions related to the response. Furthermore, it was found that the response to the transcripts of Pseudosciaena grandifolia in these reactions and the resulting conditions of 98677.doc 200533758 were forked to regulate both the genes known per se and those derived from ests, allowing the supply of Xinlai's assay targets. Dry and develop new therapies for such conditions. Therefore, in the first aspect, the present invention provides a method for assessing a tissue inflammatory response, including: quantifying a content of at least 5 transcripts or proteins encoded by the transcripts shown in Table i in a sample. And compare the rich content of the transcript or protein thus determined with the content of the transcript or protein obtained from a control sample of the cell. Preferably, the sample includes cells from a site that is believed to be affected by a tissue inflammation response in the person, sacral endothelial cells from Zhoutian, or blood, serum, or urine from a patient. In another aspect, the present invention provides a genetic wafer array suitable for use in the above method of the present invention, including at least 5 transcripts not listed in the table; a specific pair of transcripts may be considered as appropriate Zhao Ding ... ,, and, and a control group with at least one gene chip as needed. $ & In a more advanced point of view, the present invention provides eggs based on 敎 which is suitable for the above method, ^ 7 = Han including those shown in Table 1 ^ 5 I 所 所., Eight books, flat-coded protein; a control group specific to protein shellfish as needed; and a fixed control group. Gezhu ^ § Measured in a further point of view, Taiyan x month length 1 仏 determine the inflammation of the tissue and the related conditions of bismuth Yong, 笳 tf, heart or brackets: I weekly dose measurement method, The method includes a) providing a protein encoded by a transcript obtained from Table 1; 9867 ^. (100-10-200533758) b) suppressing the candidate of the egg and its activity C) determining the suppressive effect of the Xiao Whether the modulator can modulate the contact of the regulator, a candidate suppressor regulator that regulates the response of the protein

或其中該方法包括·· a) 提供培養中的内皮細胞； b) 使該細胞與該組織炎症反 觸；並 C)判定該候選的抑揚調節劑是否能夠調節至 表1之轉錄本的轉錄本之含量。 们、自 可在調節組織炎症反應之方法中， 中，使用藉著這類方法獲得的抑揚 ^動物個體 療下文討論的狀況。于的抑^即劑，而得以例如治 j其他觀點中，先前未知功能和ESTs之基因的確切、，已 穎、可能的治療介入標乾。因此，本:明提 :名碼得自表115之轉錄本之序列的載體，該序列以可 呆：之方式與轉錄該序列的啟動基因連接。這類载體可用 :蛋白質的表現上’其可以是治療劑或治療標 身^可具有直接的治療料，例如在基㈣療的應用上。 【貫施方式】 〆將在本文中提及的表j和表2分別解釋為表“或^ 一起， /表2&和2b -起’除非在前後文中分別明4地僅指定表！ 或表2的這些組成部分之一。 與組織炎症反應有關的狀況 在其第-項觀點中，本發明係關於評估組織炎症反應的 98677.d〇( -11 - 200533758 方法。如同在上文討論的，通常承認白血球涉及組織的炎 症反應火症反應可能涉及白A球跨越内皮的移動。然 而，涉及這類炎症反應的蛋白質亦可能引起白血球移動至 發炎的組織’可能參與或負責白血球的激活作用，内皮細 胞之激活作用和血營吐士、 ⑺不血g生成，或可能藉著抑制白血球或内皮 細胞之細胞凋零而影響炎症反應。 組織炎症反應通常涉及患者的狀況或疾病狀態。當在本Or wherein the method comprises: a) providing endothelial cells in culture; b) counteracting the cells with inflammation of the tissue; and C) determining whether the candidate suppressor modulator can regulate the transcripts of the transcripts of Table 1 Of content. In the methods of regulating the inflammatory response of tissues, we can use the suppression obtained by such methods to treat the conditions discussed below. In other perspectives, for example, in other perspectives, the genes of previously unknown functions and ESTs are exact, well-established, and possible therapeutic interventions. Therefore, Ben: Mingti: a vector whose name is derived from the sequence of the transcript of Table 115, which is linked in a dull manner to the promoter gene that transcribes the sequence. Such carriers are available: in the form of a protein, which can be a therapeutic agent or a therapeutic target, and can have a direct therapeutic substance, for example, in the application of basic therapy. [Implementation method] 〆 Interpret the table j and table 2 mentioned in this article as tables "or ^ together, / table 2 & and 2b-starting from" unless specified in the context, only 4 tables are specified! Or table One of these components of 2. Conditions Related to Tissue Inflammatory Responses In its first aspect, the present invention relates to the 98677.d0 (-11-200533758 method for assessing tissue inflammatory responses. As discussed above, Inflammation of white blood cells involved in tissue is generally recognized. The fire reaction may involve the movement of white blood cells across the endothelium. However, proteins involved in this type of inflammatory response may also cause white blood cells to move to inflamed tissues. 'May be involved in or responsible for the activation of white blood cells, The activation of cells and the formation of blood toast and blood gut, or may affect the inflammatory response by inhibiting the withering of white blood cells or endothelial cells. Tissue inflammatory response usually involves the patient's condition or disease state.

文中使用狀況’時，意指任何涉及、引起或與組織炎症反 應有關的疾病狀態或身體反應。 組織炎症反應可能是過度或不想要的，例如像是在炎症 疾病中的案例，如在下文中討論的那些，或可能是不充分 的像疋例如在與有缺陷之黏連蛋白質有關的狀況中，如 白血球黏連缺陷第i型和第2型（1^八〇_1和乙八〇_2)。 可藉著在内皮細胞中的改變，影響組織炎症反應和穿 透-内皮的白血球移動，例如藉著在黏連分子表現上的改 茭’其改變了白血球附著在内皮細胞上的能力，或改變了 匕子激動t „周角午之招募白血球至發炎組織。關於本發 明’在内皮細胞上的改變最好是回應炎症信號。 藉著本發明之方法評估的狀況，可以是其中改變了在炎 症反應之處或受到炎症反應影響的内皮細胞，而得以促進 炎症過程，並容許白血球移動跨越内皮的狀況。 通常在反映炎症信號時，發生白血球跨越内皮的移動。 因此，欲藉著本發明之方法評估的組織炎症反應，是其中 ♦出炎症仏號的。這類狀況的範例是炎症性疾病、血管徵 98677.doc 12 200533758 侯群動脈粥樣硬化及相關疾病、涉及腫瘤生長和慢性移 植排斥的狀況。 炎症性疾病包括炎症性腸病、牛皮癣、局部缺血的再灌 庄、成人呼吸緊迫徵候群、氣喘、過敏性鼻炎、皮膚炎、 腦膜炎、腦炎、葡萄膜炎、涉及白血球渗出的疾病、中栖 神經系統炎症性病症、阿㈣默氏症、子宮内膜異位症、 夕u生硬化症、多益、官傷害徵候群、酒精性肝炎、細菌性 肺炎、抗原-抗體複合物調解之疾肺臟的炎症（包括胸 膜炎、肺泡炎、肺炎、慢性支氣管炎、支氣管擴張、胰囊 性纖維變性和C0PD)、血管炎、結節性多動脈炎、巨細胞 動脈犬、顯微鏡下多動脈炎、子癇前症和自體免疫疾病 (如風濕性關節炎、修格蘭氏（Sj〇rgeni〇徵候群，以及腎衰 竭的多重形式’其主要歸因於針對腎臟腎小球中之内皮細 胞攻擊的自體免疫）。 在動脈粥樣硬化和相關疾病，如冠狀心臟病、周圍血管 疾病和腦血管意外中，藉著來自與斑塊結合並在内皮細胞 下之白血球的炎症信號，驅使白血球在動脈粥樣硬化斑的 部位，跨越内皮層移動至血管壁内。斑塊的不穩定性和後 續的破裂導致血栓形成和血管狹窄或閉合，可能與在斑塊 區域内之内皮細胞上的炎症影響有關。 可藉著白血球調節腫瘤生長，其從血液中移動至腫瘤 内，亚釋放直接促進腫瘤細胞生長和腫瘤血管生成的因 子。因此，癌症且特別是涉及固體腫瘤的那些亦可能是相 關的治療適應症。 98677.doc -13- 200533758 慢性移植排斥主要涉及免疫細胞跨越血管移動，p 内皮細胞攻擊的免疫，並因此適合藉著本發明之方=5 估。 這些及其他與釋放炎症信號的狀況，均可能是本發明方 法的主題。 評估組織炎症反應 在本發明中，將了解"獲自一部位（威相信是受到組織炎 症反應影響的）”之細胞的判定，涉及在從身體中移出之 後，對試樣實施的活體外方法。移出試樣的步驟，例如藉 著生檢，本身並非本發明的一部分。 此外，或作為如組織生檢之類技術以外的另一種選擇， 亦可收集體液，如血液、血清和尿，揭露在這些流體中炎 症-引起的改變。可藉著例如在試樣中，在由在表i中之序 列編碼的内皮細胞-衍生之蛋白質之富含量上的變化，證 實這類改變。 、因此’本發明提供診斷與組織炎症反應有關之狀況的方 法’包括在得自懷疑受這類狀況所苦之患者的試樣中，判 定由至少5個在表丨中之轉錄本編碼的内皮細胞_衍生之蛋 白質的富含量。 如同上文解釋的，在本發明中獲得的數據顯示，使内皮 細胞與T购、IL-W〇IL_8接觸，結果某些轉錄本產生獨 特的改變，考慮到在個體之間以及在不同内皮組織之間的 變化。這些改變可能採用反應模式的形式，或可能影響個 別的轉錄本。因此，有可能使用這些獨特的改變作為診斷 98677.doc -14- 200533758 狀況的苓考，如上文討論的那些 此外或另外，狀況的診斷、評 ^ ^ ^ 干估可旎是判定該狀況的嚴 重性或精確的臨床亞-型。亦 %认 力J月匕疋该狀況之未來過程預 ’例如監視狀況的 後的方法。而且，評估可涵蓋一段時間 治療。As used herein, "condition" means any disease state or physical response that involves, causes, or is associated with a tissue inflammation response. Tissue inflammatory responses may be excessive or unwanted, such as in cases of inflammatory diseases, such as those discussed below, or may be inadequate, such as in conditions related to defective adhesion proteins, Such as white blood cell adhesion defects type i and type 2 (1 ^ 80〇_1 and Yiba 〇_2). Changes in endothelial cells can affect tissue inflammatory response and penetration-white blood cell movement in the endothelium, for example by modifying the expression of adhesion molecules, which changes the ability of white blood cells to adhere to endothelial cells, or changes The dagger excitement „Recruitment of white blood cells to inflamed tissue at noon of the week. Regarding the present invention's change on endothelial cells is best in response to inflammatory signals. The condition assessed by the method of the present invention may be one in which changes in inflammation Where the reaction is or the endothelial cells affected by the inflammatory response, it can promote the inflammatory process and allow white blood cells to move across the endothelium. Usually, when the inflammation signal is reflected, white blood cells move across the endothelium. Therefore, the method of the present invention is intended Tissue inflammation response is evaluated, among which is the inflammation 仏. Examples of such conditions are inflammatory diseases, vascular signs 98677.doc 12 200533758 Hou Qun atherosclerosis and related diseases, involving tumor growth and chronic transplant rejection Condition: Inflammatory diseases include inflammatory bowel disease, psoriasis, ischemic reperfusion, adults Respiratory urgency syndrome, asthma, allergic rhinitis, dermatitis, meningitis, encephalitis, uveitis, diseases involving leukocyte exudation, inflammatory disorders of the mesozoic nervous system, Alzheimer's disease, endometriosis Disease, sclerosis, Duoyi, official injury syndrome, alcoholic hepatitis, bacterial pneumonia, antigen-antibody complex mediated lung inflammation (including pleurisy, alveolitis, pneumonia, chronic bronchitis, bronchiectasis , Pancreatic cystic fibrosis and COPD), vasculitis, nodular polyarteritis, giant-cell arterial dogs, polyarteritis under the microscope, preeclampsia, and autoimmune diseases (such as rheumatoid arthritis, Thugram ( Sjörgeni Syndrome, and multiple forms of renal failure, 'which is mainly due to autoimmunity against endothelial cell attacks in the renal glomeruli.) In atherosclerosis and related diseases such as coronary heart disease, peripheral In vascular diseases and cerebrovascular accidents, inflammatory signals from white blood cells that bind to plaque and under endothelial cells drive white blood cells to the site of atherosclerotic plaques Move across the endothelial layer into the blood vessel wall. Plaque instability and subsequent rupture lead to thrombosis and stenosis or closure of blood vessels, which may be related to the inflammatory effects on endothelial cells in the plaque area. Tumors can be regulated by white blood cells Growth, which moves from the blood into the tumor, sub-releasing factors that directly promote tumor cell growth and tumor angiogenesis. Therefore, cancer, especially those involving solid tumors, may also be relevant therapeutic indications. 98677.doc -13 -200533758 Chronic transplant rejection mainly involves the migration of immune cells across blood vessels, the immunity of p endothelial cells to attack, and is therefore suitable to be evaluated by the method of the present invention = 5. These and other conditions related to the release of inflammatory signals may be the method of the present invention Evaluation of Tissue Inflammatory Responses In the present invention, the determination of " cells obtained from a site (believed to be affected by a tissue inflammatory response) " will be directed to a living body performed on a sample after removal from the body外 方法。 Outside method. The procedure for removing the sample, for example by means of a biopsy, is not itself part of the invention. In addition, or as an alternative to techniques such as tissue biopsy, bodily fluids such as blood, serum, and urine can be collected to expose inflammation-induced changes in these fluids. Such changes can be confirmed by, for example, a change in the rich content of endothelial cell-derived protein encoded by the sequence in Table i in a sample. Therefore, the present invention provides a method for diagnosing a condition related to a tissue inflammation response, including determining an endothelium encoded by at least 5 transcripts in the table in a sample obtained from a patient suspected of suffering from such a condition. Cell-derived protein. As explained above, the data obtained in the present invention show that endothelial cells were brought into contact with Tmau, IL-WOIL_8, with the result that certain transcripts produced unique changes, taking into account between individuals and in different endothelial tissues Change between. These changes may take the form of response patterns or may affect individual transcripts. Therefore, it is possible to use these unique changes as a test to diagnose the condition of 98677.doc -14- 200533758, such as those discussed above. In addition or in addition, the diagnosis, evaluation of the condition ^ ^ ^ can be used to determine the severity of the condition Sexual or precise clinical subtype. It also recognizes the future process of the situation, such as the method of monitoring the situation. Moreover, the assessment can cover a period of treatment.

在其弟-項觀點中，本發明藉著比較在取自顯示炎症反 應之患者的試樣巾的轉錄本含量，與在對照組試樣中之相 同基因的轉錄本含量，提供評估组織炎症反應的方法。 如同上文討論的，該試樣可以是得自證實炎症反應之特 定組織的細胞，如内皮細胞，或者可以是含有蛋白質肢體 液’如血液、血清或尿。 以上:法的對照組試樣，通常是未受影響之細胞的試 樣—即侍自未證實組織炎症反應之組織的細胞，或咸相信 未又忒狀况衫響的細胞。較佳的是，測試和對照組試樣兩 T均是相同的細胞類型’更佳的是，測試和對照組試樣都 是内皮細胞。測試和對照組試樣最好都是相同的内皮細胞 類型，即得自相同的組織位置。 若而要，對照組試樣可取自個體的族群。在使用個體的 、羊之處可利用在得自該族群之細胞的試樣中之平均 (例如平均值或中間值）轉錄本含量進行比較。亦可使用受 y曰的組織作為對照組。通常9受影響的組織將得自從其 取知X式減樣者以外的患者。通常較佳的是，若使用受 〆曰之、、且、我作為對照組，則從其中移出該試樣之患者具 有’或相信其具有與從其中移出受試試樣之患者相同的狀 986-7.doc -15- 200533758 況。 在一些具體實施例中，本發明之方法可包括使用—個以 上的對照組；例如可將欲測試之試樣與得自相同患者之正 常或未受影響的試樣，以及得自其他患者或患者們 響試樣的轉錄本含量相比較。 心 如同上文时論的，本發明之方法交 谷許在治療之前、期間 :广視狀況。在受試試樣得自有或相信有組織炎症的 二者之處，通常該試樣最好也是在較早之相點獲自患者 的’而得以提供歷史紀錄。 力在：：:具Γ?例中，該方法容許評估特殊治療的效 之嚴=1 個時間點之單一患者中的組織炎症 生，有可能判定特殊的治療攝生法是否有確定的影 a可一種攝生法的效力，可能隨著患者戋在 的期間内有所不同。 有次在疾病過耘 ==的具體實施财，㈣檢查眾多基 夕何生自這些轉錄本之蛋白質的含 飞队 是因為我們P婉钚辑少加 不只仃本發明。這 本含的個體之間’個別基因之轉錚 改變。因此想要對數個基因 2 二1可評估至少5個’較佳的是至少H)個，而更：In its brother-item perspective, the present invention provides an assessment of tissue inflammation by comparing the transcript content of a sample towel taken from a patient showing an inflammatory response with the transcript content of the same gene in a control sample. Method of reaction. As discussed above, the sample may be a cell obtained from a specific tissue that confirms an inflammatory response, such as endothelial cells, or it may be a protein-containing limb fluid ' such as blood, serum, or urine. Above: The control sample of the method is usually a sample of unaffected cells-that is, cells that serve tissues that have not been confirmed to have an inflammatory response to the tissue, or cells that are believed not to be irritated. Preferably, both the test and control samples are of the same cell type '. More preferably, the test and control samples are both endothelial cells. The test and control samples are preferably of the same endothelial cell type, i.e. obtained from the same tissue location. If desired, the control sample may be taken from the individual's ethnic group. Where individuals and sheep are used, the average (e.g., average or median) transcript content in a sample obtained from cells from that population can be compared. A control group can also be used. Usually 9 affected tissues will be obtained from patients other than the person who learned the X-subtract. It is generally preferred that if a recipient is used, and, as a control group, the patient from whom the sample is removed has' or is believed to have the same condition as the patient from whom the test sample was removed 986 -7.doc -15- 200533758. In some embodiments, the method of the present invention may include the use of more than one control group; for example, a sample to be tested may be a normal or unaffected sample obtained from the same patient, and may be obtained from other patients or Patients compared the transcript content of the samples. Mind As mentioned above, the method of the present invention provides a wide range of conditions before and during treatment. Where the test sample is obtained from or believed to have tissue inflammation, it is usually best that the sample be obtained from the patient's earlier phase to provide a historical record. In the case of ::: In the case of Γ ?, this method allows the evaluation of the effectiveness of special treatment = 1 time point of tissue inflammation in a single patient. It is possible to determine whether the special treatment method has a certain effect. The effectiveness of a biopsy method may vary with the duration of the patient's stay. I have been working hard on the specific implementation of the disease once, and I have checked the contents of the proteins of these transcripts in many transcripts. This is because we have not added more to the invention than the invention. This individual's genes are altered between individuals. Therefore, we want to evaluate at least 5 genes for 2 2 1 genes, preferably at least 2) genes, and more:

的=少2〇個轉錄本或衍生自表i之轉錄本的而K 可個別地，或以特殊的組合，判定基因： 私度，或可判定眾多基因的表現模式。 胃的表現 在本發明的第一項觀點中，比較 所評估之轉錄本的含量 …1照組試樣中 了-因反映炎症信號而引起轉錄 98677.doc -16- 200533758 的 量 了I— » s 7向或下降。因此，有可能反映炎症信號向上_ 調節轉錄太―、 、 、本或向下-調節。對本發明而言，是否向上_調節 或向下-★思_』一 、 々即亚不重要，但與對照組多少有改變。 為了青助判定在測試和對照組試樣之間，在轉錄本 白質調節上的差異，可判定向上-或向τ_調節的特定人 這可以”倍率”增加或減少來表達。對本發明而古^ 轉錄本含量上σ在·= 20 fewer transcripts or transcripts derived from Table i and K can determine genes individually, or in special combinations: privacy, or can determine the performance patterns of many genes. Stomach manifestations In the first aspect of the present invention, the contents of the transcripts evaluated are compared ... 1 in the sample-the amount of transcription 98677.doc -16- 200533758 caused by the reflection of the inflammatory signal I— » s 7 goes down or down. Therefore, it is possible to reflect the inflammatory signal up-regulate transcription too-,-,-, or down-regulate. For the present invention, it does not matter whether it is up-regulated or down- ★ think_, it is not important, but it is somewhat different from the control group. In order to help judge the difference in transcript white matter regulation between the test and control samples, it can be judged that the specific person who is adjusted upward-or τ_ can be expressed by increasing or decreasing the "multiplier". For the present invention, the transcript content σ is

有明顯改變是：= 不重要，反而是與對照組 量上，θ Β車又重要的。在本發明中’通常在轉錄本之含 二蛋的改變’即增加或減少。對轉錄 蛋白…增加或減少的量，並沒有上 經發現在某些轉錄本之含量上有：我們已 某些蛋白質明顯的重新向上調節。…，亚可證實 節：含量的向上-或向下·調 質。在之方面 ㈣里凋即所評估之所有轉錄本或蛋白 貝“方面，更重要的是建立調節的模式。飞蛋白The obvious changes are: = not important, but in comparison with the control group, θ Β car is important. In the present invention, 'the change in the two eggs containing the transcript' is usually increased or decreased. Regarding the amount of transcribed protein ... increased or decreased, it has not been found in the content of some transcripts: we have obviously readjusted some proteins up. …, Asia can confirm the section: the content of up-or down · quenching and tempering. In this respect, all the transcripts or proteins that are evaluated are "in aspect, and more importantly, the establishment of a regulatory model. Fly protein

在本發明的一個具體實施例中， 可包括得自轉錚本，轉錄本或蛋白質 日褥綠本，或得自一或多 者。較佳的是，涉乃,士夕 蛋白貝豕族或集團 $}] ^ 5 . 在一或夕個這類蛋白質家族隹1® 士 判疋至少-個轉錄本或蛋白質之含〜 豕Λ或集團中 四、五或更多個，而更佳的是這類=:;，最好是三、 一個。 貝豕族或集團的每 通常這類集團或家族包括蛋白酶、成 細胞發送信號之蛋白質、涉及轉錄：態發生蛋白質、 細胞週期調節蛋白質、細胞通訊蛋白::的蛋白質、酵素、 貝、核蛋白、補體蛋 98677.doc -17- 200533758 白質、細胞外基質蛋白質、蛋白酵體、重金屬結合蛋白 質、TNF-受體超級家族蛋白質、HLA蛋白質、細胞黏連蛋 白質、細胞激動素/化學激動素、細胞激動素/化學激動素 受體、細胞骨架蛋白質、細胞凋零之調節劑、生長因子和 生長因子受體。 通常評估之轉錄本或蛋白質最好包括一或多個選自細胞 激動素/化學激動素、細胞激動素/化學激動素受體、細胞 骨架蛋白質、細胞外基質蛋白質、細胞凋零之調節劑、生 長因子和生長因子受體。 本發明之方法特別感興趣的是特殊轉錄本或蛋白質的調 節。可就這些本身，或以調節模式的一部分來評估之。因 此，在本發明之方法中，評估之轉錄本或蛋白質最好包括 下列的一或多個：菌落刺激因子3(粒性細胞）、菌落刺激因 子2(粒性細胞-巨噬細胞）、粒性細胞化學吸引蛋白質2、二 泛素（diubiquitin)、ELAM-1、TNF-誘導之蛋白質 6、 Exodus 1、IL-1/5、VCAM_1、ICAM-1、IAP1、TNF-可誘 導之 A20、RIPK2、MMP 10、TRAF1、JAK結合蛋白質、 雙重專一性磷酸酶4、11^6、11>_8、〇1*〇-7、乂0?-1、〇1*〇-/3、Gro-α、ENA-78、趨化因數（fractalkine)、小的可誘導 之細胞激動素亞家族A14、小的可誘導之細胞激動素家族 A5、LI7受體、類鐸（toll)/介白素1受體4、€^八八丁、^1八0-3、COX-2、Mn SOD、NO合成酶、L-犬尿胺酸水解酶、組 織因子路徑抑制劑2、昆布胺酸γ2、類·鐸受體2、天然殺 手細胞轉錄本4、TNF-α誘導之蛋白質2、陽離子胺基酸運 98677.doc -18- 200533758 載者2A、脂肪酸結合蛋白質4、tnF受體超級家族成員Ub 和TNF超級家族成員9。 更佳的是，在本發明之方法中，評估之轉錄本或蛋白質 包括下列的一或多個：菌落刺激因子3(粒性細胞）、菌落刺 激因子2(粒性細胞-巨噬細胞）、粒性細胞化學吸引蛋白質 2、一泛素、ELAM -1、TNF-誘導之蛋白質6、Exodus 1和 IL-1/5。 或者’該方法涉及判定轉錄本表現的模式，其中該轉錄 本包括至少一些在本文之表1中解釋的轉錄本。 可藉著任何適當的方法判定基因或基因們的轉錄本或蛋 白質含量。在欲檢查許多不同的基因轉錄本之處，便利的 方法是藉著試樣（直接或在產生cDNA或cRNA之後）與基因 晶片陣列的雜交作用。 在使用基因晶片技術之處，基因（當在本文中使用該名 詞時，包括表1之ESTs)全部出現在得自Affymetrix的市售 晶片上，並可根據得自製造者的草案來使用這些晶片。通 常，亦可在例如 W084/01031、WO88/1058、WO89/01157、 W093/8472、W095/18376、W095/18377、W095/24649和歐洲 專利-A-0373203中找到提供微陣列之方法及其應用，且亦 可參考此項技藝中的這些及其他文獻。 在欲檢查許多不同的蛋白質之處，便利的方法為抗體晶 片、多-標靶ELISA或蛋白質組分析。通常，亦可在例如美 國專利第6,329,209號和美國專利第2,656,508號中找到提供 蛋白質測定之方法及其應用。這類方法在此項技藝中是共 98677.doc -19- 200533758 同的。可藉著參考 http://www.marketresearch.com/map/ prod/9046ll.html獲得這類方法的更多資訊。 表1提供了基因的名稱，並可使用這些從諸如Genbank之 類的資料庫獲得它們的DNA序列與編碼蛋白質。此外，亦 可藉著在表中提供之Affymetrix整理號碼，判定在我們已 經使用之Affymetrix晶片上所使用的特殊序列，該整理號 碼是可公開獲得的，並與Genbank整理號碼直接相關。亦 藉著Genbank整理號碼提供在一些案例中的EST基因序 列。熟諳此藝者可在實行本發明時，參考Affymetrix整理 號碼或Genbank整理號碼。 表2提供在affymetrix晶片上使用的每個探針之CDNA序 列資訊，亦將其列舉在表1中。表1列舉了用來獲得在本文 中列舉之特定蛋白質/EST的探針組，而表2則提供在表1中 提及之每個探針組的cDNA序列。 在表2a和2b中，f’n”代表在每個案例中，未藉著在基因 晶片上之探針組序列探測的核酸區域。因此，為了製造盡 可能專一的陣列，僅使用全部cDNAfs中選出的區域，排除 一些介於其間的序列。排除的序列是其中已經利用” n，，置 換單一核苷酸密碼（a、g、c或t)的那些。 或者，或除此之外，可使用定量PCR方法，例如以被廣 泛應用在此項技藝中的ABI TaqMan™技術為基礎。在許多 先前技藝的公開案中描述過了 ，例如可參考 WO00/05409。PCR方法需要引子對，其按適當的距離分開 (通常50至300個鹼基），瞄準標靶基因的相反股。可按照上 98677.doc -20- 200533758 文提及的，藉著參考Genbank序列來判定引子的適當標耙 序列。 基因晶片 雖然先前技藝提供了基因晶片，其包括（作為極大陣列 的一部分）表la和lb之一或多個的基因，確認相對上較小 組的基因K評估上文討論的狀況，容許提供特別設計 過、適合用在本發明中的小晶片（訂作的基因陣列）。In a specific embodiment of the present invention, it may include derived from a transcript, a transcript or a protein, or from one or more of them. Preferably, Shiinai, Shixi protein shellfish family or group $}] ^ 5. In one or more of these protein families (1® Shi Jun) at least one transcript or protein content ~ 豕 Λ or There are four, five or more in the group, and more preferably this type =:;, preferably three or one. Each of these groups or families usually includes proteases, proteins that send signals to cells, involved in transcription: morphogenetic proteins, cell cycle regulating proteins, cell communication proteins :: proteins, enzymes, shellfish, nucleoproteins, Complement egg 98677.doc -17- 200533758 white matter, extracellular matrix protein, protease, heavy metal binding protein, TNF-receptor superfamily protein, HLA protein, cell adhesion protein, cytokinin / chemokine, cytokine / Chemokine receptors, cytoskeleton proteins, regulators of cell death, growth factors and growth factor receptors. Generally the transcript or protein to be evaluated preferably includes one or more selected from the group consisting of cytokinin / chemokine, cytokinin / chemokine receptor, cytoskeleton protein, extracellular matrix protein, regulator of cell decay, growth Factor and growth factor receptor. The method of the invention is of particular interest in the regulation of specific transcripts or proteins. These can be assessed on their own, or as part of a regulatory model. Therefore, in the method of the present invention, the transcript or protein to be evaluated preferably includes one or more of the following: colony-stimulating factor 3 (granulocyte), colony-stimulating factor 2 (granulocyte-macrophage), granulocyte Sexual cytochemistry attracts protein 2, diubiquitin, ELAM-1, TNF-induced protein 6, Exodus 1, IL-1 / 5, VCAM_1, ICAM-1, IAP1, TNF-inducible A20, RIPK2 , MMP 10, TRAF1, JAK-binding protein, dual specificity phosphatase 4, 11 ^ 6, 11 > _8, 〇1 * 〇-7, 乂 0? -1, 〇1 * 〇- / 3, Gro-α, ENA-78, chemokine (fractalkine), small inducible cytokinin subfamily A14, small inducible cytokinin family A5, LI7 receptor, toll / interleukin 1 receptor 4, ^ octadecine, ^ 180 oc-3, COX-2, Mn SOD, NO synthetase, L-kynurenine hydrolase, tissue factor pathway inhibitor 2, cuminic acid γ2, class Duo Receptor 2, natural killer cell transcript 4, TNF-α-induced protein 2, cationic amino acid 98677.doc -18- 200533758 carrier 2A, fatty acid binding protein 4, tnF receptor super home Family members Ub and TNF superfamily members9. More preferably, in the method of the present invention, the transcript or protein evaluated includes one or more of the following: colony-stimulating factor 3 (granulocyte), colony-stimulating factor 2 (granulocyte-macrophage), Granular cytochemistry attracts protein 2, ubiquitin, ELAM-1, TNF-induced protein 6, Exodus 1, and IL-1 / 5. Or'the method involves determining a pattern of transcript performance, wherein the transcript includes at least some of the transcripts explained in Table 1 herein. The transcript or protein content of a gene or genes can be determined by any suitable method. Where many different gene transcripts are to be examined, a convenient method is to hybridize the sample (directly or after the cDNA or cRNA is generated) to the gene array. Where gene wafer technology is used, genes (when the term is used herein, including the ESTs in Table 1) all appear on commercially available wafers from Affymetrix, and these wafers can be used according to the manufacturer's draft . Generally, methods and applications for providing microarrays can also be found in, for example, W084 / 01031, WO88 / 1058, WO89 / 01157, W093 / 8472, W095 / 18376, W095 / 18377, W095 / 24649, and European Patent-A-0373203 , And you can also refer to these and other literature in this art. Where many different proteins are to be examined, convenient methods are antibody wafers, multi-target ELISA or proteomic analysis. Generally, methods for providing protein assays and their applications can also be found in, for example, U.S. Patent No. 6,329,209 and U.S. Patent No. 2,656,508. This type of method is 98677.doc -19-200533758 in this art. You can learn more about these methods by referring to http://www.marketresearch.com/map/prod/9046ll.html. Table 1 provides the names of the genes, and these can be used to obtain their DNA sequences and encoded proteins from a library such as Genbank. In addition, you can also use the Affymetrix ordering number provided in the table to determine the special sequence used on the Affymetrix chip we have used. This ordering number is publicly available and directly related to the Genbank ordering number. The EST gene sequence in some cases is also provided by Genbank finishing numbers. Those skilled in the art may refer to the Affymetrix ordering number or the Genbank ordering number when practicing the present invention. Table 2 provides the CDNA sequence information for each probe used on the affymetrix wafer and is also listed in Table 1. Table 1 lists the probe sets used to obtain the specific proteins / ESTs listed herein, while Table 2 provides the cDNA sequences for each probe set mentioned in Table 1. In Tables 2a and 2b, f'n ”represents the region of the nucleic acid that was not detected by the probe set sequence on the gene chip in each case. Therefore, in order to make the array as specific as possible, only the entire cDNAfs were used. Selected regions exclude some intervening sequences. Excluded sequences are those in which a single nucleotide code (a, g, c, or t) has been replaced with "n,". Alternatively, or in addition, quantitative PCR methods can be used, such as based on ABI TaqMan ™ technology, which is widely used in this technology. Has been described in many prior art publications, see for example WO00 / 05409. The PCR method requires a pair of primers, which are separated by an appropriate distance (usually 50 to 300 bases), and target opposite strands of the target gene. The appropriate target sequence of the primer can be determined by referring to the Genbank sequence as mentioned in the above 98677.doc -20-200533758. Gene chip Although previous techniques provided a gene chip, which includes (as part of a large array) one or more of the tables la and lb, confirms that a relatively small group of genes, K, evaluates the conditions discussed above and allows for special designs The microchip (customized gene array) suitable for use in the present invention.

因此’本發明提供基因晶片，包括至少5個適合用來檢 測在表1 t顯示之至少5個轉錄本的核酸（直接或在產生 cDNA或,CRNA之後）；可視需要還有對該轉錄本專一的對 照組；並可視需要含有至少—個該基因晶片的對照組。 在該觀點的另-個具體實施例中，本發明提供基因晶片 陣列，用來檢測至少5個在表β出示的轉錄本，包括至少 5個選自表2的核冑’其能夠檢測該至少5個轉錄本的存 ^可視需要還有對該轉錄本專—的對照組，並可 還有至少一個該基因晶片的對照組。Therefore, the present invention provides a gene chip, including at least 5 nucleic acids (directly or after the production of cDNA or CRNA) suitable for detecting at least 5 transcripts shown in Table 1 t; A control group; and a control group containing at least one gene chip as required. In another specific embodiment of this point of view, the present invention provides a gene chip array for detecting at least 5 transcripts shown in Table β, including at least 5 nucleosomes selected from Table 2 which can detect the at least The storage of the 5 transcripts may optionally include a control group specific to the transcript, and there may be at least one control group of the gene chip.

基因晶片陣列包括至少5個不同的核酸 或20個不同的核酸。 1U 在理想上，在陣列中的序列數目 1轉錄本之核酸的數目（或表2序列 用Μ測表 太轰一 + i 數目）為n，對個別轉錄 ，、如組核酸的數目為n’，其中n，是從〇到2n，且在 该基因晶片上之對照組核酸的 在 測”管家”轉錄本之對照組、豐：广性對照組或檢 皮細胞t具有較高表現程度：胞轉錄本、在内 褥錄本、在欲評估之特殊内 98677.doc 21 200533758 皮類型中具有較高表現程度的轉錄本，或其類似物）是❿， 其中m是從〇到100，較佳的是從1到30，此時n+n，+m代表 在該晶片上至少50%，較佳的是至少75%，而更佳的是至 少90%的核酸。 蛋白質晶片The gene wafer array includes at least 5 different nucleic acids or 20 different nucleic acids. 1U Ideally, the number of sequences in the array 1 The number of nucleic acids in the transcript (or the number of sequences in Table 2 is too large + the number of i) is n, for individual transcription, such as the number of group nucleic acids n ' , Where n is from 0 to 2n, and the control nucleic acid on the gene chip of the "housekeeper" transcript under test, abundance: extensive control group or epidermal cell t has a higher degree of expression: cells The transcript, the inner transcript, the special transcript 98677.doc 21 200533758 in the skin type to be evaluated, or the like) is ❿, where m is from 0 to 100, preferably It is from 1 to 30, at this time n + n, + m represents at least 50%, preferably at least 75%, and more preferably at least 90% of the nucleic acids on the wafer. Protein chip

如同上文關於基因晶片所討論的，提供轉錄本和在表】 中藉此編碼的蛋白質，容許產生適當的訂作之蛋白質晶 片。可以抗體晶片之形式使用這類晶片，或可包括多-桿 革巴ELISA或蛋白質組分析。通常，可在例如美國專利第 6,329,209號和美國專利第2,656，谓號中找到提供蛋白質測 定的方法及其應用。這類方法在此項技藝中是共同的。 因此’在更進—步的觀點中，本發明提供以蛋白質為基 礎之測定’適合用在本發明上述的方法中，來評估至少5 個由包括在表1中出不的那些轉錄本編瑪之蛋白質；可視 需要還有對該蛋白質直 貝專—的對照組；並可視需要還有至少 一個該測定的對照組。 在較㈣㈣實施例中’以蛋白質為基礎之測定是抗體 晶片或EUSA’最好是多-標㈣似。 測定方法 本=月之測疋方法，可以各種格式實行，例如在蛋白 狐組份上，或在培養中的完整細胞中。 、 本發明在其第二項_ S1 ^ ^ ^ ^ 中，提供組織炎症反應或與其有 關之狀况的抑％調節劑的測定方法 . (a)提供由表丨之鱸你+ ' 之轉錄本編碼的蛋白質； 98677.doc 200533758 (b)使錢白f與其活性之候選 (Ο判定該候、, %5周即劑接觸，·並 性。，的抑揚調節劑是否能夠調節該蛋白質之活 在内皮細胞對炎症信號之反應& 處，該測定最好e # %本的向下調節之 疋取好疋針對蛋白質的活化 及判定該抑揚★月浐如θ 且5亥測疋最好涉 n周即剩是否能夠增加 體實施例中，可在該 、活植。在該具 進行収。 以mt無料的條件下 在^細胞對炎症信號之反應涉及轉 處，該測定最好是針對蛋白質活性的抑制劑，=二 好涉及判定該抑揚調節 忒利疋攻 ◦即d疋否旎夠降低蛋白質 該具體實施例中，可.1 貝之活性。在 Γ在其中該蛋白質呈右丨下杳；n 下進行測定。 貝一有正吊活性的條件 在5亥測疋方法中舌性 .^ ^ 周即的判定將視欲測定之蛋白皙 的性質而定。例如，可在疋您蛋白貝 j在该酵素之受質的存在 有酵素功能的蛋白質，使得 、/、 存右社車^ 夠調節活性之抑揚調節劑的 存在，、.，α果為較快或較慢 的天然受質或合成__ = 可以是該酵素 一 物。在任-案例中，可利用可檢 測標記標示該受質，以# e、曰* 巧用了才双 貝以便^視其轉變為終產物。 至於具有配體結合功能的蛋白質， 結合功能，以引導配體結合、i °對配體 方六^ ^ ^ ^ σ寸性之拮抗作用或激動作用的 方式，k查候k的抑揚調節劑。 至於具有DNA結合活性的所 — 蛋白貝，如轉錄調節劑，可判 疋ISi A結合或轉錄激活活性 其中抑揚調節劑能夠促進或 98677.doc -23- 200533758 降低廷類活性。例如， 人 在移動性變換測定中判定DNA結 口。或者，可將Dna與蛋白 盥聋 貝、、、口合的區域以可操作之方式 者:』連接（此外，若需要，在該dna區域和報告 間還有啟動基因區及/或轉錄開始區域），而得以 節轉Γ作用，並在發生時看到該轉錄作用的調 更2告者基因包括，例如氯黴素乙酿轉移酶，或 佺的疋螢光報告者基因，如綠螢光蛋白質。As discussed above with respect to gene chips, the provision of transcripts and the proteins encoded thereby in the table allows the generation of appropriately tailored protein chips. Such wafers may be used in the form of antibody wafers, or may include multi-rodgeba ELISA or proteomic analysis. In general, methods for providing protein assays and their applications can be found in, for example, U.S. Patent No. 6,329,209 and U.S. Patent No. 2,656. This type of method is common in this art. Therefore, 'in a more advanced point of view, the present invention provides protein-based assays' suitable for use in the above method of the present invention to evaluate at least 5 transcripts compiled from those included in Table 1 Protein; if necessary, a control group for the protein; and, if necessary, at least one control group for the measurement. In the comparative example, the 'protein based assay is an antibody chip or EUSA' is preferably multi-standard. Assay method This test method can be performed in various formats, such as on protein fox components, or in whole cells in culture. The present invention, in its second item _S1 ^ ^ ^ ^, provides a method for determining tissue inhibitors of tissue inflammation or related conditions. (A) Provide a transcript from the table Encoded protein; 98677.doc 200533758 (b) Make Qian Bai f and his candidate for activity (0 to determine the time,% 5 weeks of immediate contact, and compatibility., Whether the inhibitory modulator of the protein can regulate the activity of the protein The response of endothelial cells to inflammatory signals & where the measurement is best e #% of the down-regulation of the good, good for protein activation and determination of the inhibition In the example of whether the weekly residue can be increased, the plant can be harvested in the living plant. The harvesting is performed under the condition that the mt cell has no response to the inflammatory signal in the tumour. The determination is best directed to protein activity. Inhibitors = Erhao involves judging the inhibitory effects of regulation, that is, whether d is sufficient to reduce the protein. In this specific embodiment, the activity of .1 may be. In which the protein is in the right and lower; The measurement is performed under n. The condition of Bayi has positive hanging activity is 5 In the test method, the determination of the tongue. ^ ^ The determination of Zhou Ji will depend on the nature of the protein to be measured. For example, the protein of the enzyme function can be found in the protein substrate of the enzyme, so that, / 、 Cunyousheche ^ Presence of an inhibitor that is sufficient to regulate the activity, .., α fruit is a faster or slower natural substrate or synthesis __ = can be a substance of the enzyme. In any case, it can be Detect the substrate with a detectable label, and use #s, succinctly as the final product. As for proteins with a ligand binding function, the binding function can guide the ligand binding, i ° For the method of antagonistic or agonistic effects of the ligand square six ^ ^ ^ ^ σ sigma, k check the inhibitory regulator of k. As for the protein-shellfish that has DNA binding activity, such as a transcriptional regulator, ISi A-binding or transcription-activating activity, in which the suppressor modulator can promote or reduce the activity of the Ting class. For example, humans can determine DNA junctions in mobility shift assays. Alternatively, DNA can be used with protein deaf shellfish, ,, And the area of the mouth to be operable The way is: ”connection (in addition, if necessary, there is a promoter region and / or a transcription start region between the DNA region and the report), so that the Γ effect can be switched, and the regulation of the transcription effect can be seen when it occurs Further reporter genes include, for example, chloramphenicol beta-transferase, or tritium fluorescent reporter genes, such as green fluorescent protein.

:者’或在第三項觀點中，本發明提供組織炎症反岸或 …、有關之狀況的抑揚調節劑的測定方法，包括： (a)提供培養中的内皮細胞； ()n田胞與该狀況之候選的抑揚調節劑接觸；並 ⑷判定該候選的抑揚調節劑是否能夠調節至少一個選自 表1之轉錄本的轉錄本之含量。 在自亥方法的第一個步驟Φ 葚 中坨養内皮細胞。為了收穫及 培養細胞，可使用任何適去 ， 〜、 田的方法。關於培養内皮細胞的 技術為此項技藝中共同的。 候選的抑揚調節劑化合物可以是在藥物筛選程式中使用 的天然或合成之化學化合物。亦可使用植物、微生物或其 他生物的萃取物，其含有數個獨特或普通的組份。综合庫 技術（包括固相合成和平行合成方法學）提供了針對調節交 互作用的月匕力’測试可能極龐大數目之不同物質的有效方 法。關於天然產物、小分子和肽等等的所有方式，這類庫 及其應用為此項技藝中已知的。許多這類的庫是可從商業 上獲得的，並為了現在由太I @ g 本考X月預見之矢員型的藥物篩選程 98677.doc -24- 200533758 式而販售。 更多種類的候選之抑揚調節劑包括與蛋白質標靶結合的 抗體或其結合片段。 能夠與抗原或其他結合夥伴結合之抗體片段的實例，是 由VL、VH、C1和CH1功能部位所組成的Fab片段；由VH 和CH1功能部位所組成的Fd片段；由抗體單臂之和vh 功能部位所組成的Fv片段；由VH功能部位所組成的dAb片 &，經過分離的CDR區域和F(ab’）2片段，包括在絞鏈區藉 著二硫橋連接之兩個Fab片段的二價片段。亦包括單鏈Fv 片段可攸重組產生、表現免疫球蛋白可變功能部位的庫 中’獲彳于對蛋白質專一的抗體，例如使用λ噬菌體或絲狀 ϋ巫囷體，其在其表面上展示具有功能之免疫球蛋白結合功 月b α卩位，例如芩見W〇92/〇1〇47。這類技術容許快速地產 生對抗抗原的抗體，然後可根據本發明篩選這些抗體。 其他種類的候選分子是肽，以待抑制之蛋白質序列的片 段為基礎。特定而言，與在蛋白質中與其他蛋白質或與 DNA產生父互作用之部分_致的蛋白質片&，可能是小狀 的^數’其係作為蛋白質功能的競爭性抑制劑。這類肽的 長度可能是例如從5到2〇個胺基酸。 肽亦可提供設計模仿物的基礎。這類模仿物將以肽的分 析為基礎，判定對生物活性必要且很重要的胺基酸殘基或 側鏈的部分’以便定義藥效團，接著製造藥效團的模 型，設計在適當之三維關係中保留必要殘基或其部分的模 仿物。在此項技#中存有各種電腦協助的技術，以便更容 98677.doc -25- 200533758 易設計這類模仿物。 可建立以細胞為基礎之測定方法的組態，以便判定美因 在轉錄層面或在轉譯層面的表現。在欲測量轉錄本之處， 此=這可使用上述的本發明第一項觀點之方法，例如在基 因晶片上，藉著多重PCR或其類似物來判定之。 如同上文，在轉錄本反映炎症信號而被向下_調節之 處，該測定最好是針對增加基因表現的製劑（例如，藉著 肖加轉錄本的含量）。這類製劑可包括基因本身的㈣序 列（即匕可以疋基因治療載體）。在轉錄本反映炎症信號而 被向上-調節之處，該測定最好是降低基因表現的製劑。 可按照上述使用以細胞為基礎的測定方法來篩選候選的 抑職節劑。亦可使用它們來筛選更多種類之候選的抑揚 凋即劑，包括反義寡核苷酸。這類寡核苷酸的長度通常是 從12到25，例如大約15至20個核苷酸，並可能包括或由經 過修改之主鏈結構所組成，例如甲基膦酸醋和硫代磷酸酉旨 鲁 主鏈以便協助春核苷酸的穩定。反義募核苷酸可衍生自 標靶基因的密碼區，或得自5,或3,未轉譯區域。候選分子 可進一步包括RNAi，即短的雙股RNA分子，其為對基因 轉錄本專一的序列，或是較長的RNA序列，其可由細胞加 工成siRNA，並可將其提供給細胞，例如像DNA序列 (eliRNA或表現長干擾RNA)。它們亦可包括核酶，其專一 地瞄準轉錄本mRNA，即催化性RNA分子，其切開特殊核 酸序列的其他RNA分子。建構核酶的普通方法為此項技藝 中已知的。 9S677.doc -26 - 200533758 在本發明這此输赴μ 定方法，料蛋^ 具體實施例中，使用上述的測 調節劑。 ^性或得自表1b之轉錄本含量的抑揚 可在患者中調節組織 例如义症狀況的方法中 得的抑揚調節劑。 炎症反應及/或與其有關之狀況， 使用根據本發明之這些觀點所獲 包括組織炎症反應及 連同在藥學上可接受 因此，本發明亦提供醫藥組合物，: 'Or in a third aspect, the present invention provides a method for determining a suppressor of tissue inflammation or related conditions, including: (a) providing endothelial cells in culture; () n field cells and The candidate suppressor of this condition is contacted; and it is determined whether the candidate suppressor can regulate the content of at least one transcript selected from the transcripts of Table 1. Endothelial cells are cultured in the first step of the Zihai method Φ 葚. In order to harvest and culture cells, any suitable method can be used. Techniques for culturing endothelial cells are common in the art. Candidate modulator compounds can be natural or synthetic chemical compounds used in drug screening programs. Extracts of plants, microorganisms or other organisms can also be used, which contain several unique or common components. Comprehensive library technology (including solid-phase synthesis and parallel synthesis methodologies) provides an effective method for testing the potential for a very large number of different substances to modulate interactions. With regard to all methods of natural products, small molecules, peptides, etc., such libraries and their applications are known in the art. Many of these libraries are commercially available and are being marketed for the drug screening process 98677.doc -24- 200533758, which is currently being tested by Tai I @ g Ben Kao X Month. Further classes of candidate modulators include antibodies or binding fragments that bind to protein targets. Examples of antibody fragments capable of binding to antigens or other binding partners are Fab fragments composed of VL, VH, C1, and CH1 functional sites; Fd fragments composed of VH and CH1 functional sites; and the sum of one arm of the antibody vh Fv fragments composed of functional sites; dAb slices composed of VH functional sites & separated CDR regions and F (ab ') 2 fragments, including two Fab fragments connected by a disulfide bridge in the hinge region Bivalent fragment. Also included is a library of single-chain Fv fragments that can be recombined to produce variable functional sites of immunoglobulins and are derived from protein-specific antibodies, such as the use of lambda phages or filamentous maggots that display on their surface A functional immunoglobulin binding function bα 卩 position, see, for example, WO92 / 〇1047. Such techniques allow the rapid generation of antibodies against antigens, which can then be screened according to the invention. Other types of candidate molecules are peptides based on fragments of the protein sequence to be inhibited. In particular, a protein sheet & which is caused by a part that interacts with other proteins or with DNA in a parent, may be a small number ' which acts as a competitive inhibitor of protein function. Such peptides may be, for example, from 5 to 20 amino acids in length. Peptides can also provide the basis for designing mimics. Such mimetics will be based on the analysis of the peptides to determine the amino acid residues or side chain parts that are necessary and important for biological activity in order to define the pharmacophore, and then create a model of the pharmacophore, designed in the appropriate Mimics that retain the necessary residues or parts thereof in a three-dimensional relationship. There are various computer-assisted technologies stored in this technology #, in order to make it more suitable for 98677.doc -25- 200533758. Cell-based assays can be configured to determine the performance of Meine at the transcription or translation level. Where a transcript is to be measured, this = this can be determined using the method of the first aspect of the present invention described above, for example, on a gene chip by multiplex PCR or the like. As above, where transcripts are down-regulated to reflect inflammatory signals, the assay is best directed at agents that increase gene expression (for example, by the content of Shaw transcripts). Such preparations may include a gene sequence (i.e., a gene therapy vector). Where transcripts are up-regulated in response to inflammatory signals, the assay is preferably a preparation that reduces gene expression. Candidates can be screened as described above using cell-based assays. They can also be used to screen a wider variety of candidate stifling agents, including antisense oligonucleotides. Such oligonucleotides are typically from 12 to 25 in length, such as about 15 to 20 nucleotides, and may include or consist of modified backbone structures such as methylphosphonate and phosphorothioate The main chain is designed to assist the stability of the spring nucleotide. Antisense nucleotides can be derived from the coding region of the target gene, or from 5, or 3, untranslated regions. Candidate molecules can further include RNAi, which is a short double-stranded RNA molecule, which is a sequence specific to a gene transcript, or a longer RNA sequence, which can be processed into siRNA by a cell and provided to the cell, such as DNA sequence (eliRNA or long interfering RNA). They can also include ribozymes, which specifically target transcript mRNA, that is, catalytic RNA molecules, which cleave other RNA molecules of a particular nucleic acid sequence. Common methods for constructing ribozymes are known in the art. 9S677.doc -26-200533758 In the present invention, the determination method is used to prepare the eggs ^ In the specific embodiment, the above-mentioned measurement regulator is used. Inhibitors of the transcript content derived from Table 1b can be used in a patient to modulate tissues, such as the condition of a symptom. Inflammatory reactions and / or conditions associated therewith, obtained using these perspectives of the present invention include tissue inflammatory responses and together with pharmaceutically acceptable. Therefore, the present invention also provides pharmaceutical compositions,

/或與其有關之狀況的抑揚調節劑， 之载劑。 ^ #利用-或多個適合對個體所選擇之投藥途^的 :學上可接受之載劑，來調配抑揚調節 體 二=用的傳統無毒性固體載劑包括，例如製藥等級 ==乳糖、纖維素、纖維素衍生物、-粉、硬脂 物^石、葡萄糖、薦糖、碳酸鎂及其類似 ^。可猎者例如將抑揚調節劑和任意之佐劑溶解、分散等 ::載劑中’來製備液態的在藥學上可接受之組合物，該 载別為像是例如水、生理鹽水、含水的右旋糖、甘油、乙 醇及其類似物’藉此形成溶液或懸浮液。若需要，亦可投 與含有微量無毒性輔助物質的醫藥組合物，如濕濁劑或乳 化劑、ΡΗ緩衝製劑及其類似物，例如乙酸納、脫水山梨糖 醇早月桂酸醋、三乙醇胺、乙酸納、脫水山梨糖醇單月桂 酸醋、三乙賴油酸酯#等。製備這_ 法為熟諸此藝者已知的，或將知曉的；例：=And / or a suppressor of conditions related to it, a carrier. ^ #Using-or more suitable for the selected drug administration route ^: a scientifically acceptable carrier to formulate the yangyang regulator II = traditional non-toxic solid carriers include, for example, pharmaceutical grade == lactose, Cellulose, cellulose derivatives, -powder, stearin, stone, glucose, sucrose, magnesium carbonate and the like. The hunter can, for example, dissolve and disperse the humor modifier and any adjuvants in a :: vehicle to prepare a liquid pharmaceutically acceptable composition, such as, for example, water, physiological saline, aqueous Dextrose, glycerol, ethanol, and the like 'thereby form a solution or suspension. If necessary, pharmaceutical compositions containing trace amounts of non-toxic auxiliary substances, such as moisturizers or emulsifiers, PBS buffer preparations and the like, such as sodium acetate, sorbitan early laurate, triethanolamine, Sodium acetate, sorbitan monolaurate, triethyl oleate # and the like. The method of making this _ is known or will be known to those skilled in the art; for example: =

Remington-s Pharmaceutical Sciences, Mack Publishing 98677.doc -27- 200533758Remington-s Pharmaceutical Sciences, Mack Publishing 98677.doc -27- 200533758

Company，Easton，Pennsylvania，第 15版，1975。無論如 何，欲投與之組合物或調配物，將以有效減輕待治療個體 之症狀的用量，含有活性化合物（們）的量。 投藥路徑可視待治療之精確狀況而定，雖然因為將得自 血管系統之襯裡的内皮細胞，投與至血流中（例如藉著靜 脈内注射）是一種可能的路徑。 此外，本發明提供用在治療上之組織炎症反應及/或與 其有關之狀況的抑揚調節劑。 而且，本發明提供組織炎症反應之抑揚調節劑在製造用 來治療與該反應有關之狀況的醫藥品上的應用。 載體 確認許多先前未知功能的ESTs和其他基因，其與内皮細 胞受炎症信號調節有關，提供了在上述本發明之觀點，以 及在下文中描述之更多觀.點中有用的新筹員載體系統之基 礎0 較佳的是，將編碼在表113中列舉之轉錄本的序列以可操 之方式與控制序列連接，其能夠藉著宿主細胞提供密碼Company, Easton, Pennsylvania, 15th edition, 1975. In any event, the composition or formulation to be administered will contain the active compound (s) in an amount effective to reduce the symptoms of the individual to be treated. The route of administration may depend on the precise condition to be treated, although it is possible to administer endothelial cells obtained from the lining of the vascular system into the blood stream (for example, by intravenous injection). In addition, the present invention provides a suppressor agent for treating tissue inflammatory response and / or conditions related thereto for use in therapy. Further, the present invention provides the use of a suppressor of a tissue inflammation response for the manufacture of a pharmaceutical for treating a condition related to the response. The vector confirms many previously unknown functional ESTs and other genes, which are involved in the regulation of endothelial cells by inflammatory signals, and provides insights into the above-mentioned aspects of the present invention, as well as more aspects described below. Basis 0 Preferably, the sequences encoding the transcripts listed in Table 113 are operably linked to the control sequence, which can provide a code through the host cell

作 序列的表現，即該載體是表現載體。 、可紅作之方式連接一岡意指並列，其中所描述之組 知疋合#匕們以其想要之方式發揮功能的關係。”以可操 作之方式連接”密碼序列的對照序列，是以在可與對照序 列相容的條件下，完成密碼序列之表現的方式來連接。 適當的宿主細胞包括細菌、 和酵母菌，以及桿狀病毒系統 真核生物細胞，如哺乳動物 。可在此項技藝中獲得，表 98677.doc -28- 200533758 現異種多肽的哺乳動物細胞株，包括中國倉鼠卵巢細胞、 HeLa細胞、幼倉鼠腎臟細胞、C0S細胞及許多其他的。 載體可包括其他的序列，如啟動基因或促進子，來駕馭 ***核酸的表現，使得核酸序列以融合及/或編碼分泌信 號之核酸的形式產生多肽，以便將在宿主細胞中產生的多 肽從細胞中分泌出來。 載體可含有-或多個可選擇標記基因，例如在細菌質體The expression of the sequence, that is, the vector is a expression vector. The connection of Yigang means red tie means juxtaposition, and the group described in it is known as the relationship in which the functions are performed in the way they want. The control sequence of the "operably linked" cipher sequence is linked in such a way that the expression of the cipher sequence is completed under conditions compatible with the control sequence. Suitable host cells include bacteria, and yeasts, as well as eukaryotic cells of the baculovirus system, such as mammals. Available in this technique, Table 98677.doc -28- 200533758 mammalian cell lines with heterologous polypeptides, including Chinese hamster ovary cells, HeLa cells, baby hamster kidney cells, COS cells, and many others. The vector may include other sequences, such as a promoter or promoter, to control the expression of the inserted nucleic acid, so that the nucleic acid sequence generates a polypeptide in the form of a fusion and / or a nucleic acid encoding a secretion signal, so as to remove the polypeptide produced in the host cell Secreted. Vectors can contain-or multiple selectable marker genes, such as in bacterial plastids

中為氨节青黴素抗藥性基因，或是適合哺㈣物載體的新 黴素抗藥性基因。 載體可更進-步包括促進子序列、終止轉錄之片段、聚 腺苷酸化作用序列和其他適當的序列。 可在活體外使用載體，例如用來產生RNA或用來轉移感 染或轉化宿主細胞。亦可改造載體，以便在活體内使用， 例如在基因治療之方法中。在各種不同的宿主細胞中選殖 並表現多肽的系統’是已熟知的。載體包括基因治療載 體’例如以腺病毒為基礎之載體、腺病毒關聯病毒、逆轉 錄病毒（如HIV或MLV)，或α病毒载體。 可選擇與宿主可相容的啟動基因和其他表現調節信號， 用來α又计表現載體。例如，包括酒酵母菌和八即啟 動基因、***酵母（s.p。㈣）顧1和偷啟動基因的酵母 菌啟動基因。哺乳動物啟動基因包括金屬硫肽啟動基因， 其可反映重金屬’如鎘而被誘導。亦可使用病毒啟動基 口 Jc SV40大T抗原啟動基因或腺病毒啟動基因。所 這些啟動基因在此項技藝中均可輕易地獲得。 、 98677.doc -29- 200533758 在基因治療中用來產生由表lb之轉錄本編碼的多肽的載 體包括攜帶迷你-基因序列的載體。 可按照上述將載體轉化至適當的宿主細胞内，提供本發 月之夕肽的表現。因此，在本發明更進一步的觀點中，製 備由表lb之轉錄本編碼之多肽的方法，包括在由載體提供 編碼忒多肽之密碼序列表現的條件下，培養利用按照上述 之表現載體轉化或轉移感染的宿主細胞，並回收所表現的 夕肽亦可使用在活體外的系統來表現多肽，如網狀紅血 球溶胞產物。 貫質上經過分離之形式的藉著表lbiEST或基因編碼的 多肽或其片段，形成本發明更進一步的觀點。多肽片段的 尺寸最好是至少20個胺基酸，較佳的是從25個胺基酸至高 達全長的多肽。 本發明更進一步的觀點是核酸序列，其編碼該多肽及其 片段。可將這類核酸序列納入載體内，如上述的那些。 關於更多的細節，參見例如分子選殖··實驗室手冊 (Molecular Cloning: a Laboratory Manual):第 2版，Sambrook 專人 ’ 1989, Cold Spring Harbor Laboratory Press。在分子生物 學的最新草案（Current Protocols in Molecular Biology)， Ausubel等人編輯，j〇hn Wiley & Sons，1992 中詳細描述了 井多操縱核酸的已知技術和草案，例如在製備核酸構築 體、突變生成、定序、將DNA導入細胞内和基因表現，以 及蛋白質分析中。 在表lb之基因或EST出現在載體中之處，可在架構中將 98677.doc -30- 200533758 或可為了反義 其與轉錄開始區域連接，以便轉譯該序列 RN A的轉錄，使其為反義的方位。 實例 TNFa、IL-10和介白素_8調節轉錄本富含量Among them are ampicillin resistance genes, or neomycin resistance genes suitable for feeding vectors. Vectors may further include promoter sequences, fragments that terminate transcription, polyadenylation sequences, and other suitable sequences. Vectors can be used in vitro, for example to produce RNA or to transfer infection or transform host cells. Vectors can also be modified for use in vivo, for example in methods of gene therapy. Systems for the selection and expression of polypeptides in a variety of different host cells are well known. Vectors include gene therapy vectors ' such as adenovirus-based vectors, adenovirus-associated viruses, retroviruses (such as HIV or MLV), or alphavirus vectors. A host-compatible promoter and other expression-regulating signals can be selected for α and expression vectors. For example, they include Saccharomyces cerevisiae and Baji promoter genes, Saccharomyces cerevisiae (s.p. ㈣) Gu1, and yeast promoter genes that steal promoter genes. Mammalian promoter genes include metalthiopeptide promoter genes, which can be induced by reflecting heavy metals' such as cadmium. It is also possible to use a viral promoter Jc SV40 large T antigen promoter or an adenovirus promoter. All these promoter genes are easily available in this technique. 98677.doc -29- 200533758 The vectors used in gene therapy to produce the polypeptide encoded by the transcript of Table Ib include vectors carrying mini-gene sequences. The vector can be transformed into an appropriate host cell as described above to provide the expression of the peptide of this month. Therefore, in a further aspect of the present invention, a method for preparing a polypeptide encoded by a transcript of Table 1b includes culturing a vector for transformation or transfer using the expression vector described above under the condition that the coding sequence encoding the 忒 polypeptide is provided by a vector. Infected host cells and recovered expressed peptides can also be expressed in vitro using systems such as reticulocyte lysates. A further aspect of the present invention is formed in a qualitatively isolated form by the polypeptide or fragment thereof encoded by Table 1biEST or a gene. The size of the polypeptide fragment is preferably at least 20 amino acids, and more preferably from 25 amino acids up to the full length of the polypeptide. A further aspect of the invention is a nucleic acid sequence which encodes the polypeptide and fragments thereof. Such nucleic acid sequences can be incorporated into a vector, such as those described above. For more details, see, for example, Molecular Cloning: A Laboratory Manual: 2nd Edition, Sambrook Specialist '1989, Cold Spring Harbor Laboratory Press. Current protocols in Molecular Biology, edited by Ausubel et al., John Wiley & Sons, 1992, describe well-known techniques and drafts for manipulating nucleic acids in detail, such as in the preparation of nucleic acid constructs , Mutation generation, sequencing, DNA introduction into cells and gene expression, and protein analysis. Where the gene of Table 1b or EST appears in the vector, 98677.doc -30-200533758 may be included in the architecture or it may be linked to the transcription initiation region for antisense in order to translate the sequence RN A transcription into Antonymous orientation. Example TNFa, IL-10, and interleukin-8 regulate transcript-rich content

欲容許研究丁购L介白素ϋ表本富含量的 影響’將七個獨立的HUVEC之原始培養物與了心、介白 素W和介白素8各15毫微克/毫升的混合物_起培養 小時。然後使用從這些培養物中萃取出的⑽&製備複雜 的CRNA探針，將其與Affymetnx仍从基因晶片（一種 12,600-元件Affymetrix基因陣列晶片）雜交。 基因晶片數據的分析 整體地調整轉錄本富含量數據（"平均差異"），使每個晶 片的中間基因表現（排除對照組基因）為丨。欲確保在陣列之 間轉錄本表現程度是可比較的，在與對照組陣列比較時， 將"R”統計軟體系統的"L0ESS”功能應用在每個陣^ :對 數轉化平均差異值上.。所選出之對照組陣列，是按歐基里 德（Euclidean)距離對其他六個對照組擁有最密切類似ς的 陣列。 然後使用CyberT演算法（7.03版；滑動窗=3〇1，貝氏 (Bayes)估計值=21)，比較標準化了的轉錄本富含量。該演 算法是非成對的T-檢定，藉著在以資料組中其他轉錄^的 方差為基礎之前算入貝氏（Baysian)而加以修改（L〇ng等人 2001，J· Biol Chem 276，19937-19944)。 為了更進一步的統計分析，使用” R，，統計軟體系統和 98677.doc -31 - 200533758To allow for the study of the effect of Dinggou L interleukin ϋ surface rich content 'a mixture of seven independent HUVEC original cultures with 15 ng / ml of heart, interleukin W and interleukin 8_ Start cultivating hours. The ⑽ & extracted from these cultures was then used to prepare complex CRNA probes, which were then hybridized with Affymetnx from a gene chip (a 12,600-element Affymetrix gene array chip). Analysis of Gene Wafer Data The transcript-rich data (" average difference ") was adjusted as a whole so that the intermediate gene expression (excluding the control gene) of each wafer was 丨. To ensure that the transcript performance between the arrays is comparable, the "R" statistical software system's "L0ESS" function is applied to each array when comparing with the control array: .. The selected control array is the array that has the closest similarity to the other six control groups according to the Euclidean distance. Then the CyberT algorithm (version 7.03; sliding window = 301, Bayes estimate = 21) was used to compare the standardized transcript rich content. This algorithm is an unpaired T-test and was modified by calculating it into Baysian based on the variance of other transcriptions in the dataset (Long et al. 2001, J. Biol Chem 276, 19937 -19944). For further statistical analysis, use "R", statistical software system and 98677.doc -31-200533758

GeneSpring表現分析軟體（Silicon Genetics，Redwood City, Ca) 〇 按它們編碼之蛋白質的功能，使用GO資料庫 (www.geneontology.org)、Entrez(www.ncbi.nlm.nih.gov/entrez) 或 OMIM(www.ncbi.nlm.nih.gov:80/entrez/Omim)資料庫， 來分類個別的轉錄本。 在表中，以在7個實驗中不成對的平均值來表達倍率變 化（即治療炎症之平均值/對照組之平均值）。 在不同的内皮細胞類型中，在轉錄本含量上的差異 欲判定是否可在不同的内皮細胞類型中比較轉錄體 (transcriptome)的調節作用，我們使用人類冠狀動脈内皮 細胞（HCAEC)和人類子宮微血管内皮細胞（UtMVEC)，獲 得更多的培養物。 按照上述以炎症信號處理三種不同的細胞類型，並在三 種細胞類型的每一個中，評估轉錄本富含量的調節程度。 亦判定在三種細胞類型之間的調節模式。發現大部分的轉 錄本在全部的三種細胞類型中均受到調節，而有些僅在三 種細胞類型之兩種或一種中受到調節。 咸相信在全部三種細胞類型中均受到調節的那些轉錄 本，在本發明的各種方法中是特別有用的，因為它們可能 在影響不同器官的各種炎症狀況中是有意義的。 此外，亦發現在全部三種内皮細胞類型中，被炎症信號 調節的轉錄本，亦有在HUVEC中強烈地被炎症信號調節 的傾向。 9S677.doc -32- 200533758 一致數據 表la和lb顯示一組一致的轉錄本。是以在利用差異為二 或多個因素（按任一方向）的炎症介體處理之前和之後，其 含量具有低於0.001之貝氏P值為基礎而選出這些。根據基 因家族將這些分組。 表1顯示在HUVEC細胞，以及在HCAEC和UtMVEC細胞 中的調節程度。 ESTs 許多先前未知功能的ESTs和基因，確認與本發明有關， 在本發明之各種方法中是特別令人感興趣的，亦成為用在 治療上可能的治療劑。在表lb中概述這些。在表2b中出示 用來分離這些ESTs之探針的特定序列。 材料和方法： 内皮細胞的製備 在微血管内皮細胞生長培養基-2(EBM-MV， Biowhittaker)中培養分離自7個不同個體的HUVECs。以人 類上皮生長因子、氫基可體松、血管内皮生長因子、人類 纖維母細胞生長因子、人類重組類胰島素生長因子、抗壞 血酸、健大黴素、兩性黴素-B和FBS(5%)的專利混合物 (Microvascular BulletkitTM試劑，Biowhittaker)補充該培養 基。在繼代5時，將每個HUVEC分離株平分至兩個1 75平 方公分的培養燒瓶中，並使其生長至70%匯合。關於每個 EUVEC分離株，以含有IL-8、IL-1/5和TNF-ce各15毫微克之 雞尾酒的新鮮培養基置換一個燒瓶中的生長培養基。僅以 98677.doc -33 - 200533758 新鮮的培養基置換在重複培養物中的培養基，作為對照 組。再培養以細胞激動素-處理之HUVECs和對照組24小 時。 從Biowhittaker購得單一捐贈者-衍生之人類冠狀動脈 ECs和子宮肌層微血管ECs。培養細胞，並在與HUVECs相 同的條件下處理。 RNA萃取 使用Trizol試劑（Gibco/BRL，UK)，從每個培養物中萃取 RNA，接著通過RNeasyTM自旋管柱（Qiagen，UK)和乙醇沉 澱整理。使用Aligent2100生物分析儀，評估RNA的完整 性。 RNA的分析 根據Affymetrix草案製備生物素基化之標把cRNA，與 Affymetrix人類U95Av2晶片雜交，並使用微陣列套裝軟體 4.0或5.0版，整體地調整。GeneSpring performance analysis software (Silicon Genetics, Redwood City, Ca) 〇 Use the GO database (www.geneontology.org), Entrez (www.ncbi.nlm.nih.gov/entrez) or OMIM according to the function of the protein they encode (www.ncbi.nlm.nih.gov:80/entrez/Omim) database to classify individual transcripts. In the table, the change in magnification (ie, the average value for the treatment of inflammation / the average value for the control group) is expressed as the average of the unpaired values in the 7 experiments. Differences in transcript content among different endothelial cell types To determine whether the regulatory effects of transcriptome can be compared in different endothelial cell types, we use human coronary artery endothelial cells (HCAEC) and human uterine microvessels Endothelial cells (UtMVEC) for more cultures. Three different cell types were treated with inflammatory signals as described above, and in each of the three cell types, the degree of regulation of transcript rich content was evaluated. The mode of regulation between the three cell types was also determined. It was found that most of the transcripts were regulated in all three cell types, while some were only regulated in two or one of the three cell types. It is believed that those transcripts that are regulated in all three cell types are particularly useful in the various methods of the invention because they may be of interest in a variety of inflammatory conditions affecting different organs. In addition, it was also found that in all three endothelial cell types, transcripts regulated by inflammatory signals also tended to be strongly regulated by inflammatory signals in HUVEC. 9S677.doc -32- 200533758 Consistent data Tables la and lb show a consistent set of transcripts. These were selected on the basis that their content had a P-value of less than 0.001 before and after treatment with inflammatory mediators with a difference of two or more factors (in either direction). These are grouped by gene family. Table 1 shows the degree of regulation in HUVEC cells, as well as in HCAEC and UtMVEC cells. ESTs Many previously unknown functions of ESTs and genes have been confirmed to be relevant to the present invention, and are of particular interest in the various methods of the present invention, and have also become therapeutically possible therapeutic agents. These are summarized in Table lb. The specific sequences of the probes used to isolate these ESTs are shown in Table 2b. Materials and methods: Preparation of endothelial cells HUVECs isolated from 7 different individuals were cultured in microvascular endothelial cell growth medium-2 (EBM-MV, Biowhittaker). Human epithelial growth factor, hydrocortisone, vascular endothelial growth factor, human fibroblast growth factor, human recombinant insulin-like growth factor, ascorbic acid, gentamicin, amphotericin-B, and FBS (5%) A proprietary mixture (Microvascular Bulletkit ™ reagent, Biowhittaker) supplements the medium. At passage 5, each HUVEC isolate was bisected into two 1,75 cm2 culture flasks and allowed to grow to 70% confluence. For each EUVEC isolate, the growth medium in one flask was replaced with fresh medium containing 15 nanograms of each of IL-8, IL-1 / 5 and TNF-ce. Only the medium of 98677.doc -33-200533758 fresh medium was replaced in the repeated culture as the control group. Cytokinin-treated HUVECs and controls were recultured for 24 hours. Single donor-derived human coronary artery ECs and myometrial microvascular ECs were purchased from Biowhittaker. Cells were cultured and treated under the same conditions as HUVECs. RNA extraction RNA was extracted from each culture using Trizol reagent (Gibco / BRL, UK), followed by RNeasy ™ spin columns (Qiagen, UK) and ethanol precipitation. Use the Aligent 2100 Bioanalyzer to assess RNA integrity. RNA analysis Biotinylated cRNAs were prepared according to Affymetrix drafts, hybridized with Affymetrix human U95Av2 wafers, and overall adjusted using the Microarray Suite software version 4.0 or 5.0.

9867Tdoc 34- 200533758 1. Schraufstatter, I· U., Chung, J.r and Burgerf M. (2001) 工L-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways, American Journal of Physiology 280, L1094-L1103 2· Dinarello, C. A. (1998) Interlukin-1f interleukin-1 receptors and interleukin-1 receptor antagonist. Intern Rev Immunol 16, 457-499 3. Aggarwal^ B. B. (2000) Tumour necrosis factor receptors associated signalling molecules and their role in activation of apoptosis, JNK and NF-kB. Annals of «Rheuma亡ic Disease 5 9 (suppl) , i6_il6 4. Madger L. A,, and Poberf J. S. (2001) TNF Signalling in9867Tdoc 34- 200533758 1. Schraufstatter, I.U., Chung, Jr and Burgerf M. (2001) Engineering L-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways, American Journal of Physiology 280, L1094-L1103 2 Dinarello, CA (1998) Interlukin-1f interleukin-1 receptors and interleukin-1 receptor antagonist. Intern Rev Immunol 16, 457-499 3. Aggarwal ^ BB (2000) Tumour necrosis factor receptors associated signalling molecules and their role in activation of apoptosis, JNK and NF-kB. Annals of «Rheuma 亡 ic Disease 5 9 (suppl), i6_il6 4. Madger L. A ,, and Poberf JS (2001) TNF Signalling in

Vascular Endothelial Cells. Experimental and Molecular Pathology 10, 317-325Vascular Endothelial Cells. Experimental and Molecular Pathology 10, 317-325

5. 0TNeill, L. A. J·, and Dinarello, C. A. (2000) The IL-l receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunology Today 21, 206-209 6. Li, A·, Dubey, S·, Varney, M. L., and Singh, R. K. (2002) 工nterleukin-8-induced proliferation, survival, and MMP production in CXCR1 AND CXCR2 expressing human umbilical vein endothelial cells. Microvascular Research 64, 476-481 7. . StrieterA R. M., Polverini, P, J., Arenberg, D. A., Walz, A., Opdendakker, G·, Van Damme, J., and Kunkel, S. L· (1995) Role of C-X-C chemokines as regulators of angiogenesis in lung cancer. Journal of Leukocyte Biology 57, 752-762 8. Kitadai, Y., Haruma, K·, Sumii, K., Yamamoto, S., Ue, T·, Yokozaxi, H·, Yasui, W., Ohmotof Y., Kajiyama, G.,5. 0TNeill, LA J ·, and Dinarello, CA (2000) The IL-l receptor / toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunology Today 21, 206-209 6. Li, A ·, Dubey , S ·, Varney, ML, and Singh, RK (2002) nterleukin-8-induced proliferation, survival, and MMP production in CXCR1 AND CXCR2 expressing human umbilical vein endothelial cells. Microvascular Research 64, 476-481 7.. StrieterA RM, Polverini, P, J., Arenberg, DA, Walz, A., Opdendakker, G ·, Van Damme, J., and Kunkel, S. L · (1995) Role of CXC chemokines as regulators of angiogenesis in lung cancer Journal of Leukocyte Biology 57, 752-762 8. Kitadai, Y., Haruma, K ·, Sumii, K., Yamamoto, S., Ue, T ·, Yokozaxi, H ·, Yasui, W., Ohmotof Y. , Kajiyama, G.,

Fidler,工· J., and Tahara, E. (1998) Expression of interleukin-8 correlates with vascularity in human gastric carcinomas. American Journal of Pathology 152f 93-100Fidler, G. J., and Tahara, E. (1998) Expression of interleukin-8 correlates with vascularity in human gastric carcinomas. American Journal of Pathology 152f 93-100

-35 - 98677.doc 200533758-35-98677.doc 200533758

表1 a由炎症介艘調節的轉錄本 探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 265 s at ELAM-1 6401 94.12407276 0 52.80610911 48.1406623 38453 at ICAM-2 3384 1 -4.919652169 0 -3.172225055 -4.196639495 38454 g at ICAM-2 — 3384 -4.273813746 6.85E-14 -3.222848571 -4.756558142 41433 at VCAM-1 7412 41.92536277 4.44E-16 19.68500876 7.08367969 590 at ICAM-2 3384 -4.355207383 0 -2.939770867 -3.513733465 32640 at 1CAM-1 3383 30.3312002 0 22.98537954 17.77124304 1372_at TNF_誘導之蛋白質 6(CD44之高度同系物 7130 72.77639371 2.64E-12 102.0554489 132.4555661 583 s at VCAM-1 7412 21.72229281 4.54E-14 12.47672759 8.084337024 37286一 at 神經元的CAM 4897 3.057294936 2.6E-11 4.522694277 3.046878985 37287_at 神經元的CAM 4897 2.118308598 0.00016866 3.028078666 1.459527209 1126 一 s at CD44 5.908575047 1.69E-10 5.164794759 4.433329962 2036 s at CD44 960 5.280337829 4.8E-10 4.346849483 4.014976193 31472 s at CD 44 5.028849347 1.41E-10 5.268492975 3.537170724 41475_at 神經損傷誘導蛋白質 (Ninjurin)l 4814 4.254200441 1.25E-12 8.697922867 2.140258321 1385_at TGFP誘導之基因大-h3 (抑制細胞黏連） 7045 3.148463542 4.32E-08 2.554804325 5.017906407 40493 at CD44 960 2.314611255 0.000015 2.992670691 2.618091 422 41534_at 原妈黏素 (Protocadherin)(腦-心臟） 5099 -3.130162659 5.24E-11 -3.950798183 -1 .443373336 37288_g at 神經元的CAM 4897 2.32386108 0.00000712 3.096319968 2.468852275 41266-at 整聯蛋白，α6 3655 -2.905539743 6.34E-14 -6.44331 7073 -4.825692909 33410一at 整聯蛋白，α6Β 3655 -3.555248053 5.49E-11 -3.460672051 -7.074752389 33411_g_at 整聯蛋白，α6Β 3655 -4.026330886 1.62E-08 -7.112851076 -10.75631742 120一at 整聯蛋白，αΐ 3672 5.394552373 5.46E-11 8.278974088 15.79277269 37484_at 整聯蛋白，αΐ 3672 7.015160862 2.69E-09 15.12333177 12.4415517 257一 at 整聯蛋白，aV 3685 2.327640731 0.00028556 1.203881437 3.677134895 39071一at 整聯蛋白，aV 3685 4.093727059 1.11E-15 2.057183486 4.695101368 406一at 整聯蛋白，β4 3691 -2.516147583 0.0000113 -1.175618714 1.170070754 2073_s_at 妈黏素(cadherin)13， Η-鈣黏素(心臟） 1012 2.169729435 0.00074496 1.053001021 1.209382473 39878一 at 原鈣黏素9 5101 -4.59180328 0.00000262 -4.173958272 -1.224867651 34760一 at C-型外源凝集素 BIMLEC前驅物 9936 -2.931920451 0.0004342 -2.84198351 -3.951644147 40698_at C-型外源凝集素 9976 -2.090795467 0.0000308 -1.170337293 -1.25139979 細胞凋零調節 1717—s at ΙΑΡ1 330 13.25120688 2.22E-16 24.06057001 10.88814977 595_at TNF-可誘導的Α20 7128 23.99969733 0 24.66171353 36.22756341 41384_at RIPK2 (與 CD40 交互 作用） 8767 33.39955874 0 10.50930817 27.65190479 3 3 243一 at TNF-可誘導之蛋白質(？ 細胞凋零之陰性介體） 25816 4.48308487 3.44E-15 5.51 0033362 5.437586371 1237—at 迷早反應3 8870 2.804193654 3.02E-13 3.090900931 7.298832868 1867—at CLARP 8837 2.893895437 2.76E-12 2.965378608 2.598032615 36578_at muib(iap同系物） 329 2.20726532 6.59E-10 1.998610122 2.184746309 1868 g at CLARP 8837 2.741709407 2.77E-12 1.892992274 2.014557756 40049一at 與死亡有關之蛋白質激 酶1 1612 -2.30278615 2.27E-07 -3.336581791 -2.887251828 41816_at 卞斯蛋白酶招募功能部 位家族，成員10 29775 -2.002003766 3.91E-08 -2.186735523 -2.029925561 2002_s_at 相關蛋白質A1 597 2.613589324 0.00018672 3.9139111 1.474571201 98677.doc •36- 200533758Table 1a Explanation of transcript probe set regulated by inflammatory mediators HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 265 s at ELAM-1 6401 94.12407276 0 52.80610911 48.1406623 38453 at ICAM-2 3384 1 -4.919652169 0 -3.172225055 -4.196639495 38454 g at ICAM-2 — 3384 -4.273813746 6.85E-14 -3.222848571 -4.756558142 41433 at VCAM-1 7412 41.92536277 4.44E-16 19.68500876 7.08367969 590 at ICAM-2 3384 -4.355207383 0 -2.939770867 -3.513733465 32640 at 1CAM-1 3383 30.3312002 0 22.98537954 17.77124304 1372_at TNF_ induced protein 6 (high homolog of CD44 7130 72.77639371 2.64E-12 102.0554489 132.4555661 583 s at VCAM-1 7412 21.72229281 4.54E-14 12.47672759 8.084337024 37286-at neuron's CAM 4897 3.057294936 2.6E-11 4.522694277 3.046878985 37287_at neuron's CAM 4897 2.118308598 0.00016866 3.028078666 1.459527209 1126-s at CD44 5.908575047 1.69E-10 5.164794759 4.433329962 2036280 s at CD44 4.8E-10 4.346849483 4.014976193 31472 s at CD 44 5.028849347 1.41E-10 5.268492975 3.537170724 41475_at Ninjurin 1 4814 4.254200441 1.25E-12 8.697922867 2.140258321 1385_at TGFP-induced gene large-h3 (inhibits cell adhesion) 7045 3.148463542 4.32E-08 2.554804325 5.017906407 40493 at CD44 960 2.314611255 0.000015 2.992670691 2.618091 422 41534_at Protocadherin (brain-heart) 5099 -3.130162659 5.24E-11 -3.950798183 -1.443373336 37288_g at CAM 4897 2.32386108 0.00000712 3.096319968 2.468852275 41266-at integrin, α6 3655 -2.905539743 6.34E-14 -6.44331 7073 -4.825692909 33410-at integrin, α6B 3655 -3.555248053 5.49E-11 -3.460672051 -7.074752389 33411_g_at integrin, α6B 3655 -4.026330886 1.62E-08 -7.112851076 -10.75631742 120 one at Integrin, αΐ 3672 5.394552373 5.46E-11 8.278974088 15.79277269 37484_at Integrin, αΐ 3672 7.015160862 2.69E-09 15.12333177 12.4415517 257-at integrin, aV 3685 2.327640731 0.00028556 1.203881437 3.677134895 39071-at Integrin, aV 3685 4.093727059 1.11E-15 2.057183486 4.695101368 406-at integrin, β4 3691 -2.516147583 0.0000113 -1.175618714 1.170070754 2073_s_at cadherin 13, cadherin (heart) 1012 2.169729435 0.00074496 1.053001021 1.209382473 39878-at pro-cadherin 9 5101 -4.59180328 0.00000262 -4.173958272 -1.224867651 34760 one at C-type exogenous lectin BIMLEC precursor 9936 -2.931920451 0.0004342 -2.84198351 -3.951644147 40698_at C-type exogenous lectin 9976 -2.090795467 0.0000308- 1.170337293 -1.25139979 Cell withering regulation 1717-s at ΙΑΡ1 330 13.25120688 2.22E-16 24.06057001 10.88814977 595_at TNF-inducible A20 7128 23.99969733 0 24.66171353 36.22756341 41384_at RIPK2 (Interaction with CD40) 8767 33.39955874 065.50930817 -Inducible protein (? Cell-negative negative mediator) 25816 4.48308487 3.44E-15 5.51 0033362 5.437586371 1237-at early response 3 8870 2.804193654 3.02E-13 3.090900931 7.298832868 1867-at CLARP 8837 2.893895437 2.76E-12 2.965378608 2.598032615 36578_at muib (iap homolog) 329 2.20726532 6.59E-10 1.998610122 2.184746309 1868 g at CLARP 8837 2.741709407 2.77E-12 1.892992274 2.014557756 40049 a at death-related protein kinase 1 1612 -2.30278615 2.27E-07 -3.336581791 -2.887251828 41816_at Weiss protease recruits functional site families, Member 10 29775 -2.002003766 3.91E-08 -2.186735523 -2.029925561 2002_s_at Related Protein A1 597 2.613589324 0.00018672 3.9139111 1.474571201 98677.doc • 36- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 574_s_at 卡斯蛋白酶1(介白素 1β，轉化酶） 834 3.488039515 0.0000158 5.206924741 2.289334595 蛋白酶 1006一 at ΜΜΡ 10(基質溶解素 (stromelysin)) 4319 20.673524 2.94E-09 54.6446216 12.16240346 1227一 g_at 蛇毒蛋白(disintegrin)/ 金屬蛋白酶功能部位 17(TNF-a轉變酶） 6868 3.813351746 5.27E-09 1.452030457 5.668869009 129_g_at 組織蛋白酶K(重度骨 發育障礙 (pycnodysostosis)) 1513 2.462139973 0.00000177 1.72558228 2.194661317 38466_at 組織蛋白酶K(重度骨 發育障礙 1513 3.61266368 3.93E-10 2.466729636 1.611499 128 一 at 組織蛋白酶Κ(重度骨 發育障礙） 1513 5.727765674 3.54E-07 2.95658194 1.862569449 41239丄at 組織蛋白酶S 1520 6.1789631 94 0.00010333 8.40720437 7.301525957 生長因子/生長因子受體/結合蛋白質 1736一at 類胰島素生長因子結合 蛋白質6 3489 -2.014 0.0147 -1.977 -6.608 3402 l_at 介白素2 3558 -3.214 0.0041 1.1863 -1.027 36782—s一at 類胰島素生長因子2 (促生長因子Α) 3481 2.9966 0.0197 1.0001 -1 3 7319一at 類胰島素生長因子結合 蛋白質3 3486 -2.874 0.0035 -3.36 -1.027 159—at VEGFC 7424 2.357296176 2.67E-10 9.487520679 2.865003832 3746 l_at 促血管生成素 (Angiopoietin)2 285 -2.319743262 0.00000274 -5.975448459 -7.930241469 1951 一 at 促企管生成素2 285 -2.685484753 4.54E-07 -8.039282583 -12.53026423 36879_at 内皮細胞生長因子 1(金小板衍生的） 1890 9.066420458 9.88E-09 23.27852668 1.656563558 1334_s_at 菌落刺激因子3(粒性 細胞） 1440 110.4374129 0 107.7019762 95.9009041 1400_at 菌落刺激因子2(粒性 細胞·巨噬細胞） 1437 59.85609631 0 128.3173278 115.0807894 I401_g_at 菌落刺激因子2(粒性 細胞-巨嗤細胞） 1437 69.22778507 0 164.8742173 97.00671055 3978 l_at IGFBP4 3487 -2.32298013 2.63E-12 -3.202031547 -2.304705004 1573__at 金小板-衍生之生長因 子P多肽 5155 2.364292483 4.72E-1 1 2.310014432 3.576039834 1737 s at IGFBP4 3487 -3.134319307 3.56E-11 -4.670559679 -2.390794223 1987一 at 金小板-衍生之生長因 子受體，a多肽 5156 5.414971 705 2.1E-10 5.239961839 5.489227387 1897一at 轉化生長因子，p受體 Π 7049 -3.075084973 0.00000944 -2.117136032 -6.575991342 1761 at 類血小板·衍生之生長 因子受體 5157 2.189929847 0.0000242 1.689699835 -1.658417287 1968一 g_at 血小板-衍生之生長因 子受體，a多肽 5156 3.489609752 0.00017615 7.37795097 3.825705997 36314_at Fms-相關之酪胺酸激酶 3配體 2323 2.928004872 4.78E-07 4.061156781 1.381073451 1664一 at 類胰島素生長因子2 — 2.468425254 1.35E-07 1.028272127 1.071858187 1591_s_at 類胰島素生長因子2 3481 4.554886105 0.000025 2.380846497 -1.095495947 骨形態發生蛋白質 98677.doc -37- 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 574_s_at Cassin 1 (interleukin 1β, invertase) 834 3.488039515 0.0000158 5.206924741 2.289334595 protease 1006-at ΜΜ 10 (stromelysin) 4319 20.673524 2.94E-09 54.6446216 12.16240346 1227-g_at disintegrin / metalloproteinase functional site 17 (TNF-a converting enzyme) 6868 3.813351746 5.27E-09 1.452030457 5.668869009 129_g_at cathepsin K (pycnodysostosis) 1513 2.462139973 0.00000177 1.72558228 2.194661317 38466_at cathepsin K (severe bone development disorder 1513 3.61266368 3.93E-10 2.466729636 1.611499 128 one at cathepsin K (severe bone development disorder) 1513 5.727765674 3.54E-07 2.95658194 1.862569449 41239 丄 at cathepsin S 1520 6.1789631 94 0.00010333 8.40720437 7.301525957 growth factor / growth factor receptor / binding protein 1736-at insulin growth factor-like protein 6 3489 -2.014 0.0 147 -1.977 -6.608 3402 l_at interleukin 2 3558 -3.214 0.0041 1.1863 -1.027 36782-s-at insulin-like growth factor 2 (growth factor A) 3481 2.9966 0.0197 1.0001 -1 3 7319-at insulin-like growth factor-binding protein 3 3486 -2.874 0.0035 -3.36 -1.027 159-at VEGFC 7424 2.357296176 2.67E-10 9.487520679 2.865003832 3746 l_at Angiopoietin 2 285 -2.319743262 0.00000274 -5.975448459 -7.930241469 1951 one at anabolic angiogenin 2 285 -2.685484753 4.54E-07 -8.039282583 -12.53026423 36879_at Endothelial cell growth factor 1 (derived from gold plate) 1890 9.066420458 9.88E-09 23.27852668 1.656563558 1334_s_at Colony stimulating factor 3 (granulocyte) 1440 110.4374129 0 107.7019762 95.9009041 1400_at Colony stimulating factor 2 ( Granulocytes and macrophages) 1437 59.85609631 0 128.3173278 115.0807894 I401_g_at Colony-stimulating factor 2 (granulocytes-macrophages) 1437 69.22778507 0 164.8742173 97.00671055 3978 l_at IGFBP4 3487 -2.32298013 2.63E-12 -3.202031547 -2_304705004 1 plate - Raw growth factor P polypeptide 5155 2.364292483 4.72E-1 1 2.310014432 3.576039834 1737 s at IGFBP4 3487 -3.134319307 3.56E-11 -4.670559679 -2.390794223 1987 one at gold platelet-derived growth factor receptor, a peptide 5156 5.414971 705 2.1 E-10 5.239961839 5.489227387 1897-at Transforming growth factor, p receptor Π 7049 -3.075084973 0.00000944 -2.117136032 -6.575991342 1761 at platelet-like · derived growth factor receptor 5157 2.189929847 0.0000242 1.689699835 -1.658417287 1968-g_at platelet-derived growth factor Receptor, a polypeptide 5156 3.489609752 0.00017615 7.37795097 3.825705997 36314_at Fms-related tyrosine kinase 3 ligand 2323 2.928004872 4.78E-07 4.061156781 1.381073451 1664-at insulin-like growth factor 2 — 2.468425254 1.35E-07 1.028272127 1.071858187 1591_s_at insulin-like growth Factor 2 3481 4.554886105 0.000025 2.380846497 -1.095495947 Bone morphogenetic protein 98677.doc -37- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 40333 at BMP4 652 -8.689531567 2.23E-11 -11.51217679 -13.66978546 1114 at BMP4 652 -5.224251224 1.06E-10 -8.834024069 -3.466831976 1113 at BMP2 650 4.225472624 5.05E-10 5.016446479 10.99944132 40367 at BMP-2A 650 3.76567886 2.92E-09 5.685709393 9.647738498 細胞發送信號 849 g—at TRAF1 7185 17.5138547 0 8.878582574 11.87121514 848_at TRAF1(信號轉導） 7185 7.479968747 0 7.120389129 7.914739757 1633一 g一at pim-2致癌基因(絲胺酸 蘇胺酸激酶） 11040 9.160464547 0 14.689145 15.21104429 32737一 at Rac2(小GTP結合蛋白 質） 5880 3.658480457 3.89E-15 2.744061787 .789830328 38433一at AXL受體酪胺酸激酶 558 -2.808585886 1.27E-13 -3.296941327 -2.91 3417469 32736一at ras-相關的C3肉毒毒 素受質2 28963 2.682083886 4.5E-13 1.753959656 1.421575242 962一at BMX非-受體酪胺酸激 酶 660 -2.535033842 2.24E-1 0 -2.901 079423 -3.416983113 1278一 at 酪胺酸激酶，受體Axl， Alt.接合2 一 -2.419620683 .58E-1 2 -2.432209903 -3.146520458 35666—at 赛門福林 (semaphorin)3F 6405 -2.323822657 1.19E-11 -3.747425517 •3.105083997 41592_at JAK結合蛋白質 8651 15.5029436 4.44E-16 13.24058381 18.69333246 37745一 s一at 抑制腫瘤發生5(調節 MAPK1/ERK2 激酶） 6764 3.798748042 8.78E-12 1.673006765 3.978556319 35414 s at Jagged 1 182 3.938751608 3.97E-10 1.916173689 3.913844547 38129_at 甘油激酶 2710 4.156535178 2.03E-11 4.389062428 4.783183323 33925_at 神經顆粒素 (neurogranin)(蛋白質激 酶C受質） 4900 -2.874103959 1.01E-09 -2.584237728 -2.07114957 37637—at G·蛋白質信號3的調節 劑 5998 2.316785124 1.21E-09 2.467991159 3.293642315 32616 at v-yes-1 4067 3.430788342 7.13E-11 2.724701376 1.854721285 1402_at V-yes-1同系物， Lyn(酪胺酸激酶） 4067 3.523004339 1 .58E-08 2.854373847 1.829548828 3770 l_at G-蛋白質信號2之調節 劑（負調節劑） 5997 2.813879055 2.08E-08 3.885900214 3.315667451 36215一at 蛋白質激酶，cAMP-依 賴性，催化的，β 5567 -2.628783273 1.51E-08 -3.752926478 -6.755566769 1674_at ν-yes-l同系物1 7525 -2.152710145 3.31E-08 -1.530253982 -2.804444302 36233一at 3’-破酸腺苷5’-墙醯硫 酸合成酶2 9060 2.027727485 4.72E-08 1.510192698 -1.077558923 38130_s_at 甘油激酶(睪丸專一的） — 7.973762615 2.5E-09 8.684790212 2.068851 547 1788_s_at 雙專一性磷酸酶4(負 向調節MAP激酶） 1846 -11.76290841 7.65E-07 -2.071776576 -3.485764407 1637—at MAPKAP 激酶 3 7867 -2.1 82787462 0.00000659 -2.402844278 -4.904366595 34273—at G-蛋白質信號4的調節 劑 -2.496810967 2.85E-07 -4.377804301 -9.38699972 34272一 at G-蛋白質信號4的調節 劑 5999 -3.344620441 9.24E-09 -6.561315389 -16.14378204 1652一at pim-2致癌基因（絲胺酸 蘇胺酸激酶） 11040 2.699937636 1.09E-09 3.836282227 4.323718343 31862_at Wnt 5A 7474 4.219642672 0.0000149 -1.366311375 1.011983622 1669 at Wnt-5a 7474 3.479040912 0.00069919 •1.444116368 1.01235564 1457一 at JAK 1 3716 2.045332134 6.78E-08 1.365238795 1.006354866 1845一 at MAP激酶激酶4 6416 2.521 474928 0.00063222 2.41305386 •1 .836490086 98677.doc -38- 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 40333 at BMP4 652 -8.689531567 2.23E-11 -11.51217679 -13.66978546 1114 at BMP4 652 -5.224251224 1.06E-10 -8.834024069 -3.466831976 1113 at BMP2 650 4.225472624 5.05E-10 5.016446479 10.99944132 40367 at BMP-2A 650 3.76567886 2.92E-09 5.685709393 9.647738498 Cell sends signal 849 g-at TRAF1 7185 17.5138547 0 8.878582574 11.8712151 848_at Signal transduction) 7185 7.479968747 0 7.120389129 7.914739757 1633-g-at pim-2 oncogene (serine threonine kinase) 11040 9.160464547 0 14.689145 15.21104429 32737-at Rac2 (small GTP-binding protein) 5880 3.658480457 3.89E-15 2.744061787 .789830328 38433-at AXL receptor tyrosine kinase 558 -2.808585886 1.27E-13 -3.296941327 -2.91 3417469 32736-at ras-related C3 botulinum toxin receptor 2 28963 2.682083886 4.5E-13 1.753959656 1.421575242 962-at BMX Non-receptor tyrosine kinase 660 -2.535033842 2.24E-1 0 -2.901 079423 -3.41698 3113 1278-at tyrosine kinase, receptor Axl, Alt. Conjugation 2-2.419620683 .58E-1 2 -2.432209903 -3.146520458 35666-at semaphorin 3F 6405 -2.323822657 1.19E-11 -3.747425517 • 3.105083997 41592_at JAK binding protein 8651 15.5029436 4.44E-16 13.24058381 18.69333246 37745 one s one at inhibits tumorigenesis 5 (regulates MAPK1 / ERK2 kinase) 6764 3.798748042 8.78E-12 1.673006765 3.978556319 35414 s at Jagged 1 182 3.938751608 3.97E-10 1.916173689 3.913844547 38129_at Glycerin Kinase 2710 4.156535178 2.03E-11 4.389062428 4.783183323 33925_at Neurogranin (protein kinase C substrate) 4900 -2.874103959 1.01E-09 -2.584237728 -2.07114957 37637-at G · protein signal 3 regulator 5998 2.316785124 1.21 E-09 2.467991159 3.293642315 32616 at v-yes-1 4067 3.430788342 7.13E-11 2.724701376 1.854721285 1402_at V-yes-1 homolog, Lyn (tyrosine kinase) 4067 3.523004339 1 .58E-08 2.854373847 1.829548828 3770 l_at G-protein Signal 2 regulator (negative regulator) 5997 2.8138 79055 2.08E-08 3.885900214 3.315667451 36215-at protein kinase, cAMP-dependent, catalytic, β 5567 -2.628783273 1.51E-08 -3.752926478 -6.755566769 1674_at ν-yes-l homolog 1 7525 -2.152710145 3.31E-08- 1.530253982 -2.804444302 36233-at 3'-adenosine 5'-wall sulphate synthase 2 9060 2.027727485 4.72E-08 1.510192698 -1.077558923 38130_s_at Glycerin kinase (specific for testicles) — 7.973762615 2.5E-09 8.684790212 2.068851 547 1788_s_at double Specific phosphatase 4 (negatively regulates MAP kinase) 1846 -11.76290841 7.65E-07 -2.071776576 -3.485764407 1637-at MAPKAP kinase 3 7867 -2.1 82787462 0.00000659 -2.402844278 -4.904366595 34273-at modulator of G-protein signal 4- 2.496810967 2.85E-07 -4.377804301 -9.38699972 34272-at G-protein signal 4 regulator 5999 -3.344620441 9.24E-09 -6.561315389 -16.14378204 1652-at pim-2 oncogene (serine threonine kinase) 11040 2.699937636 1.09E-09 3.836282227 4.323718343 31862_at Wnt 5A 7474 4.219642672 0.0000149 -1.366311375 1.011983 622 1669 at Wnt-5a 7474 3.479040912 0.00069919 • 1.444116368 1.01235564 1457a at JAK 1 3716 2.045332134 6.78E-08 1.365238795 1.006354866 1845a at MAP kinase kinase 4 6416 2.521 474928 0.00063222 2.41305386 • 1 .836490086 98677.doc -38- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 40648_at c-mer原-致癌基因酪胺 酸激酶 10461 -2.063640257 0.0000592 -2.378445569 -2.262491022 3 8880一at 老鼠促細胞***劑激活 之蛋白質激酶結合蛋白 質1可能的異物種同源 基因(ortholog) 23005 2.215609357 4.77E-09 1.944472584 1.888827336 2014一s一 at 促細胞***劑-激活之 蛋白質激酶激酶6 5608 -2.618846506 0.00012111 -2.956702088 -5.484778343 1223一 at PCTAIRE蛋白質激酶 3 5129 2.680986947 0.00064597 2.263745506 1.108537941 3 7221一 at 蛋白質激酶，cAMP-依 賴性，調節第Π型，β 5577 -2.08567496 0.00000622 -2.915269541 -2.071 588434 2024 s at v-yes-1 4067 2.379576108 1.34E-08 2.920175571 1.392260421 323_at 絲胺酸激酶Psk-Hl — -2.016724782 0.0000125 -1.359560601 -1.12682497 481一at SNF-1相關之激酶 54861 -2.583587042 0.00000144 -1.719525409 -2.586396156 細胞激動素/化學激動素 431一at 化學激動素(C-X-C基 序)配體10 3627 2.8162 0.0131 21.833 6.9624 35061_at 化學激動素(C-X-C基 序)配體11 6373 2.1907 0.0158 19.314 6.2232 36444_s_at 化學激動素(C-C基序） 配體23 6368 -4.887 0.001 •2.116 -1.418 38299_at IL6 3569 24.14721637 0 22.56841253 61.56303356 35372_r_at IL8 3576 15.51735527 0 15.55547961 12.15835237 1369 s at IL8 --- 41.62876467 0 22.98760049 12.09571155 34022 at Gro-γ 2921 48.02792301 0 73.86427422 86.20366678 3 5410一 at 粒性細胞化學吸引蛋白 質2 6372 121.6423946 0 114.3849865 29.67507825 40385_at Exodus-l(MIP-3a) 6364 82.45859231 0 189.9224072 106.6857086 34375 at MCP-1 — 14.29518512 0 3.308055282 11.6027416 875 g—at MCP-1 6347 10.76460673 0 3.43922774 8.863220251 37187 at Gro-β 2920 39.20393321 0 14.16208753 39.61686592 408 at Gro-a — 23.14045021 0 6.291677693 7.986953794 35025_at ENA-78(親神經激活作 用） 6374 11.02707172 4.25E-10 9.840379417 41 .69374269 874 at MCP-1 6347 5.836636513 2.11E-15 4.481375208 9.794572686 1520 s at IL-Ιβ 3553 91.84552248 8.47E-13 205.4748788 177.3630307 33849_at 前細胞菌落促進因 子 10135 3.813578354 3.97E-10 4.108018493 4.081292457 39402__at IL-Ιβ 3553 31.54329146 3.09E-13 82.81 268573 85.84762636 823_at 趨化因數 6376 17.68369443 2.56E-12 19.7422482 22.71709814 33790_at 小的可誘導之細胞激動 素A15 6358 -12.67742209 1.52E-08 -48.34300032 -66.0221188 1403一 s—at 小的可誘導之細胞激動 素 A5(RANTES) 6352 11.20684756 5.42E-07 37.22680311 12.48514714 1405_i_at 小的可誘導之細胞激動 素 A5(RANTES) 6352 85.06201489 0.00049761 72.24870591 43.38032562 38488 s at IL15 3600 2.963696814 0.00000871 4.781012455 3.292355333 36445_at 化學激動素(C-C基序） 配體23 6368 -3.602748819 0.00039698 -2.406722814 -1.030688433 3 7823一at 化學激動素(C-C基序） 配體8 6355 23.02933617 0.00052146 258.0717884 125.0305056 37712_g_at 肌細胞促進子-結合因 子 2 ; MEF2 一* -4.26612691 2.43E-07 -5.003135162 -6.008429791 37565—at 單核細胞對相關的巨噬 細胞分化 23531 2.119735439 0.0000216 1.403749822 1.977961258 98677.doc -39- 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 40648_at c-mer pro-oncogene tyrosine kinase 10461 -2.063640257 0.0000592 -2.378445569 -2.262491022 3 8880-at mouse mitogen-activated protein kinase binding protein 1 possible heterologous gene (ortholog) 23005 2.215609357 4.77E-09 1.944472584 1.888827336 2014-at- mitogen-activated protein kinase Kinase 6 5608 -2.618846506 0.00012111 -2.956702088 -5.484778343 1223-at PCTAIRE protein kinase 3 5129 2.680986947 0.00064597 2.263745506 1.108537941 3 7221-at protein kinase, cAMP-dependent, regulates type II, β 5577 -2.08567496 0.00000622 -2.915269541 -2.071 588434 2024 s at v-yes-1 4067 2.379576108 1.34E-08 2.920175571 1.392260421 323_at serine kinase Psk-Hl — -2.016724782 0.0000125 -1.359560601 -1.12682497 481-at SNF-1 related kinase 54861 -2.583587042 0.00000144 -1.719525409 -2.586396156 Chemokine / chemokine 431-at Kinetin (CXC motif) ligand 10 3627 2.8162 0.0131 21.833 6.9624 35061_at Chemokinin (CXC motif) ligand 11 6373 2.1907 0.0158 19.314 6.2232 36444_s_at Chemokinin (CC motif) ligand 23 6368 -4.887 0.001 • 2.116 -1.418 38299_at IL6 3569 24.14721637 0 22.56841253 61.56303356 35372_r_at IL8 3576 15.51735527 0 15.55547961 12.15835237 1369 s at IL8 --- 41.62876467 0 22.98760049 12.09571155 34022 at Gro-γ 2921 48.02792301 0 73.86427422 86.20366 6462 3642 0 114.3849865 29.67507825 40385_at Exodus-l (MIP-3a) 6364 82.45859231 0 189.9224072 106.6857086 34375 at MCP-1 — 14.29518512 0 3.308055282 11.6027416 875 g—at MCP-1 6347 10.76460673 0 3.43922774 8.863220251 37187 at Gro-β 2920 3920 2039 3920 2039 3920 2039 3920 208 at Gro-a — 23.14045021 0 6.291677693 7.986953794 35025_at ENA-78 (neurophilic activation) 6374 11.02707172 4.25E-10 9.840379417 41 .69374269 874 at MCP-1 6347 5.836636513 2.11E-15 4.481 375208 9.794572686 1520 s at IL-Ιβ 3553 91.84552248 8.47E-13 205.4748788 177.3630307 33849_at Pro-cell colony promoting factor 10135 3.813578354 3.97E-10 4.108018493 4.081292457 39402__at IL-Ιβ 3553 31.54329146 3.09E-13 82.81 268573 85.84762636 823_43 E-12 19.7422482 22.71709814 33790_at small inducible cytokine A15 6358 -12.67742209 1.52E-08 -48.34300032 -66.0221188 1403 one s-at small inducible cytokine A5 (RANTES) 6352 11.20684756 5.42E-07 37.22680311 12.48514714 1405_i_at Small inducible cytokine A5 (RANTES) 6352 85.06201489 0.00049761 72.24870591 43.38032562 38488 s at IL15 3600 2.963696814 0.00000871 4.781012455 3.292355333 36445_at Chemokinin (CC motif) Ligand 23 6368 -3.602748819 0.00039698-2.406 -At chemokinin (CC motif) ligand 8 6355 23.02933617 0.00052146 258.0717884 125.0305056 37712_g_at myocyte promoter-binding factor 2; MEF2 one * -4.26612691 2.43E-07 -5.0031 35162 -6.008429791 37565-at monocyte-related macrophage differentiation 23531 2.119735439 0.0000216 1.403749822 1.977961258 98677.doc -39- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 細胞激動素/化學 ”敦動素受ΐΐ -- 13 70一at IL7受體 3575 9.161091199 0 4.303383875 8.240362396 36227_at 受體 3575 18.86860288 0 21.47752128 19.22542292 40322 <il 頰介白素1受體1 9173 2.413606464 4.3E-14 3.10203053 1.491371089 36377_at 介白素18受體1 8809 4.044516303 2.99E-11 5.074365709 3.86178169 3 7493一 at 酏洛刺激因子2受體， 1439 3.657465472 5.4E-11 4.215999509 4.372152437 41677 at 受體α 3601 2.771385255 3.93E-09 6.171752712 4.132002608 40310_at 類鐸/介白素1受艚4 7097 17.04231159 6.34E-08 41.69446428 92.69458196 1061_at )|、曰京U)受體，α 3587 2.396040273 0.00025159 1.656307749 2.726745302 1086_at 菌洛刺激因子2受备， β，低親和力 1439 3.132593874 0.00070665 3.024617357 -1.320929175 37494_at 菌落刺激因子2受艘， β，低親和力 1439 2.857904787 0.00000274 4.308632923 1.561972298 轉錄調節 1052一 s一 at LUAAi/促進子結合蛋白 質，5(COX-2啟動基因調 節） 1052 11.91692976 0 11.83059529 10.65191899 2049 s at jun B 3726 5.153898931 1.81E-14 3.431192771 6.223449667 1461_at MAD-3(編碼 Ι·κ-β 活 性） 4792 10.50494004 0 8.003192106 5.490720521 38438 at NFkB(p1〇5) " 4790 4.04722666 0 4.805775558 3.759579948 545 g at NFkB(p5〇) 4791 4.794779209 7.11E-15 9.451858522 5.944229815 1377 at NFkB(p1〇5) 4790 4.434308127 0 3.02369062 3.934373217 1378 g at NFkB(p105) 4790 5.534025442 1.11E-16 7.587979568 5.198094808 669_s_at 干擾素調節因子l 3659 7.50488352 1.73E-14 7.563755727 4.851132396 40362 at NFKB2(p49/pl〇〇) 4791 5.793454912 1.11E-16 7.300267454 7.131728502 35724_at Pirin(轉錄輔因子） 8544 -3.930125583 6.44E-15 -4.412262675 -4.67615839 32786 at jun Β 3726 3.920893987 5.77E-12 2.207915162 3.564535817 31895—at 基本的亮胺酸拉鍊轉錄 因子1 571 4.475370873 1.25E-14 5.111364686 4.25002483 570一 at RELB(抑制 NFkB) 5971 3.894337906 9.21 E-15 3.223675004 3.270575768 40088一at 核受體交互作用蛋白質 1 8204 3.771630231 1.19E-13 4.396979347 3.998851735 37353_g_at 核抗原Spl〇〇(刺激Ets-1的轉錄活性） 6672 2.880868474 1.02E-10 2.394226199 2.256154686 35638_at 核心-結合因子，（X次 單元2 ;週期素D-相關 的 862 -4.316374281 5.68E-13 -4.593414984 -2.069158236 34720一 at 核因子I/B 4781 -2.891380748 9.37E-12 -5.585236612 -6.207114141 36057_at 犰狳重複蛋白質 ALEX2 9823 3.105240733 1.54E-11 1.835928633 2.175918631 544—at NFkB(P50) 4791 7.587736834 4.66E-15 10.21368896 6.96686111 38944_at MAD-3同系物 4088 2.544980211 2.89E-11 2.527083313 1.211400339 41743 丄 at 轉錄因子ΠΑ-交互作用 蛋白質(TNF-可誘導的） 10133 3.2823426 8.83E-12 2.335070811 1.505620716 37352一at 核抗原SplOO(刺激Ets-1的轉錄活性） 6672 3.210793569 1.98E-11 2.197590225 2.387759855 1433 g at MAD-3 Π 4088 2.098641883 8.83E-09 1.666043623 1.27364714 41742_s_at 轉錄因子ΠΑ-交互作用 蛋白質(TNF-可誘導的） 10133 3.401140074 4.64E-13 2.930879849 1.665969002 36825_at 刺激反·作用因子 (50kDa)，病毒轉錄之 阻遏物 10346 2.40612763 7.67E-09 1.625963386 1.795469106 32588_s_at EGF-反應因子2 678 -2.246354328 4.4E-09 -3.889915623 -3.550964514 98677.doc -40- 200533758Probe set description site connected to HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = 1) MVEC FC (n = 1) Cytokines / Chemicals "Dactin receptor-13 70-at IL7 Receptor 3575 9.161091199 0 4.303383875 8.240362396 36227_at receptor 3575 18.86860288 0 21.47752128 19.22542292 40322 < il buccal interleukin 1 receptor 1 9173 2.413606464 4.3E-14 3.10203053 1.491371089 36377_at interleukin 18 receptor 1 8809 4.044516303 2.99E-11 5.074365709 3.86178169 3 7493-at panorium stimulating factor 2 receptor, 1439 3.657465472 5.4E-11 4.215999509 4.372152437 41677 at receptor α 3601 2.771385255 3.93E-09 6.171752712 4.132002608 40310_at Tudor / Interleukin 1 receptor 4 7097 17.04231159 6.34E- 08 41.69446428 92.69458196 1061_at) |, said Beijing U) receptor, α 3587 2.396040273 0.00025159 1.656307749 2.726745302 1086_at Bacteria-stimulating factor 2 prepared, β, low affinity 1439 3.132593874 0.00070665 3.024617357 -1.320929175 37494_at colony-stimulated factor 2 received, β, low Affinity 1439 2.857904787 0.00000274 4.308632923 1.561972298 Transcriptional regulation 1052-s-at LUAAi / promoter-binding protein, 5 (COX-2 promoter gene regulation) 1052 11.91692976 0 11.83059529 10.65191899 2049 s at jun B 3726 5.153898931 1.81E-14 3.431192771 6.223449667 1461_at MAD-3 (encoding I · κ-β Active) 4792 10.50494004 0 8.003192106 5.490720521 38438 at NFkB (p1〇5) " 4790 4.04722666 0 4.805775558 3.759579948 545 g at NFkB (p5〇) 4791 4.794779209 7.11E-15 9.451858522 5.944229815 1377 at NFkB (p1308205) 0790 4.906 4.906 4.906 3.934373217 1378 g at NFkB (p105) 4790 5.534025442 1.11E-16 7.587979568 5.198094808 669_s_at interferon regulator l 3659 7.50488352 1.73E-14 7.563755727 4.851132396 40362 at NFKB2 (p49 / pl〇〇) 4791 5.793454912 1.11E-16 7.300267454_131131rin (Transcription Cofactor) 8544 -3.930125583 6.44E-15 -4.412262675 -4.67615839 32786 at jun B 3726 3.920893987 5.77E-12 2.207915162 3.564535817 31895-at Basic Leucine Zipper Transcription Factor 1 571 4.475370873 1.25E-14 5.111364686 4.25002483 570 one at REL B (inhibition of NFkB) 5971 3.894337906 9.21 E-15 3.223675004 3.270575768 40088-at nuclear receptor interaction protein 1 8204 3.771630231 1.19E-13 4.396979347 3.998851735 37353_g_at nuclear antigen SplOO (stimulates the transcriptional activity of Ets-1) 6672 2.880868474 1.02E -10 2.394226199 2.256154686 35638_at core-binding factor, (X times unit 2; cyclin D-related 862 -4.316374281 5.68E-13 -4.593414984 -2.069158236 34720 one at nuclear factor I / B 4781 -2.891380748 9.37E-12 -5.585236612 -6.207114141 36057_at Armadillo repeat protein ALEX2 9823 3.105240733 1.54E-11 1.835928633 2.175918631 544-at NFkB (P50) 4791 7.587736834 4.66E-15 10.21368896 6.96686111 38944_at MAD-3 homolog 4088 2.544980211 2.89E-11 2.527083313 1.211 400339 41743 丄ΠΑ-interaction protein (TNF-inducible) 10133 3.2823426 8.83E-12 2.335070811 1.505620716 37352-at nuclear antigen SplOO (stimulates the transcriptional activity of Ets-1) 6672 3.210793569 1.98E-11 2.197590225 2.387759855 1433 g at MAD-3 Π 4088 2.098641883 8.83E-09 1.666043623 1.2736 4714 41742_s_at Transcription factor Π-interacting protein (TNF-inducible) 10133 3.401140074 4.64E-13 2.930879849 1.665969002 36825_at Stimulation counteracting factor (50kDa), a repressor of viral transcription 10346 2.40612763 7.67E-09 1.625963386 1.795469106 32588_s_at EGF- Response factor 2 678 -2.246354328 4.4E-09 -3.889915623 -3.550964514 98677.doc -40- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 40091一at bcl-6(轉錄阻遏物） 604 3.560324596 2.07E-10 4.016477251 4.918915862 32794 g at T細胞受體p位點 6957 -4.582802536 1.56E-10 -6.335942518 -5.302631449 35844一at 聯合蛋白聚糖 (syndecan)4(細胞内通 訊） 6385 6.189681078 2.01E-10 9.509706352 7.651058689 205_g_at 同源異形盒A4 3201 2.867789963 1.07E-09 1.253183174 1.356465181 3328 l_at IKK-相關的激酶ε 9641 3.036807944 1E-13 2.812228259 3.715110089 38276 at ΙκΒε 4794 2.587016943 4E-10 3.454608864 1.573492134 463_g—at 核因子Ι/Β 4781 -3.326218015 3.38E-09 -2.789337322 -2.93715476 40511一at GATA-結合蛋白質3(Τ-細胞抗原調節） 2625 -3.077856942 1.74E-09 -2.214428235 -1.15998505 1102 一 s一at 糖皮質激素受體α 2908 2.639244551 〇.〇〇〇〇〇〇28 3.1698879 2.569716707 873一 at 同源異形盒Α5 — 2.56550767 5.85E-07 1.16961 3734 1.194134559 32168_s_at 唐氏症決定性區域基因 1 1827 2.2161 8204 0.0000103 2.997097995 1.558897138 40493_at 鋅指蛋白質 6(CMPX1)，功能未知 960 2.314611255 0.000015 2.992670691 2.618091422 40393_at 同源異形盒A4 3201 4.225364843 1.13E-10 1.732294373 1.372777345 39742_at TRAF-交互作用因子 10010 2.142165615 0.0000156 1.785436095 2.694870743 33113—at Cbp/p300-交互作用轉 活化劑 10370 -2.08039694 6.98E-08 -1.71 0148426 -2.094438928 204一 at 同源異形盒A4 3201 6.799784725 3.76E-12 2.135352044 1.228357243 38439一 at 類核因子1(?鐵蛋白基 因表現） 4779 2.105432331 1.08E-10 1.731916025 2.233679314 35992一 at 肌蛋白(musculin)(轉錄 阻遏物） 9242 4.59261857 1.66E-07 5.0459609 9.910746814 3 8278—at 抑揚調節劑認知因子1 10865 2.090810626 1.95E-07 1.797705792 1.362064745 1577_at ***受體 367 -2.998677788 2.74E-07 1.084402729 -2.024294255 33439一 at 轉錄因子8(抑制IL-2 表現） 6935 2.463550746 1.13E-07 1.432420689 2.276427567 36690一at 糖皮質激素受體，淋巴 細胞 2908 2.202243881 3.5E-08 1.694016378 1.871546701 39032_at TGFP刺激蛋白質(調節 C-型鈉尿肽基因） 8848 -2.226498199 2.04E-07 -2.979839304 -1.851582699 32034一at 類Krnppel轉錄因子 7764 2.247161582 9.04E-07 2.1386648 1.611108294 287_at 激活之轉錄因子3 467 4.037944598 0.00021361 5.867934682 2.449017154 3 7419—g一 at POU功能部位，第2 類，轉錄因子2 5452 3.570311319 8.54E-07 10.2030961 7.279581414 3 7417一at POU功能部位，第2 類，轉錄因子2 5452 3.15917466 1.82E-09 6.743320713 3.658601746 943_at runt-相關的轉錄因子i 861 3.123404286 3.88E-11 2.595679083 2.208405598 393_s_at rum-相關的轉錄因子！ 861 2.718511505 5.28E-07 2.094702547 1.753450444 39421一at rum-相關的轉錄因早1 861 2.330472883 1.54E-08 2.842674795 1.989573274 535_s_at NFKB2(p49/pl〇〇) _ 4791 7.014437801 8.77E-09 12.09195342 6.581215622 40823_s_at 轉錄因子NFATx4 _ 4775 2.078620759 0.00095663 -1.45270611 -1.629367546 33130一 at 问源異形盒D1 3231 -5.00861908 3.68E-08 -2.579094814 -5.352803906 35824_at 銲指蛋白質238 10472 -2.383931066 6.72E-07 -4.13316475 -3.964515214 32034_at 鲜指蛋白質217 … 7764 2.247161582 9.04E-07 2.1386648 1.611108294 3968 l_at 鲜指蛋白質145(類-Krupple) 7704 2.477517897 0.00000829 1.736511126 1.220799652 41612_at 鋅指蛋白質264 9422 4.296329969 0.0000447 -1.079860264 -6.156102305 39633_at S100妈結合蛋白質A3 6274 2.829339235 0.00036814 12.49571209 5.162186098 40126_at 成對的中胚層同源異形 盒1 5396 3.283107586 0.00034973 10.49393725 6.156341582 40199_at msh同源異形盒同系物 1(果蠅） 4487 2.409909357 0.0000071 2.521903121 2.708781174 215—g_at msh同源異形盒同条物 4487 2.329390033 0.0002391 3.803589095 7.060846295 98677.doc -41 - 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 40091 at bcl-6 (transcriptional repressor) 604 3.560324596 2.07E-10 4.016477251 4.918915862 32794 g at T cell receptor p site 6957 -4.582802536 1.56E-10 -6.335942518 -5.302631449 35844 one at syndecan 4 (intracellular communication) 6385 6.189681078 2.01E-10 9.509706352 7.651058689 205_g_at Homeomorphic Box A4 3201 2.867789963 1.07E-09 1.253183174 1.356465181 3328 l_at IKK-related kinase ε 9641 3.036807944 1E-13 2.812228259 3.715110089 38276 at ΙκΒε 4794 2.587016943 4E-10 3.454608864 1.573492134 463_g-at nuclear factor Ι / Β 4781 -3.326218015 3.38 -2.789337322 -2.93715476 40511 at a binding GATA-3 (Τ- cell antigen regulation) protein 2625 -3.077856942 1.74E-09 -2.214428235 -1.15998505 1102 at a s a glucocorticoid receptor α 2908 2.639244551 〇.〇〇〇〇〇 〇28 3.1698879 2.569716707 873-at homeobox A5 — 2.56550767 5.85E-07 1.16961 3734 1.194134559 32168_s_at Decisive region of Down's disease Gene 1 1827 2.2161 8204 0.0000103 2.997097995 1.558897138 40493_at Zinc finger protein 6 (CMPX1), function unknown 960 2.314611255 0.000015 2.992670691 2.618091422 40393_at Homeomorphic box A4 3201 4.225364843 1.13E-10 1.732294373 1.372777345 39742_at TRAF-Interaction factor 100694 2.095615 1.095165 1.095165 1.095165 --At Cbp / p300-interaction transactivator 10370 -2.08039694 6.98E-08 -1.71 0148426 -2.094438928 204-at homeobox A4 3201 6.799784725 3.76E-12 2.135352044 1.228357243 38439-at nuclear factor 1 (? Ferritin Gene expression) 4779 2.105432331 1.08E-10 1.731916025 2.233679314 35992-at musculin (transcriptional repressor) 9242 4.59261857 1.66E-07 5.0459609 9.910746814 3 8278-at inhibitory factor cognitive factor 1 10865 2.090810626 1.95E-07 1.797705792 1.362064745 1577_at estrogen receptor 367 -2.998677788 2.74E-07 1.084402729 -2.024294255 33439-at transcription factor 8 (inhibits IL-2 expression) 6935 2.463550746 1.13E-07 1.432420689 2.276427567 36690-at glucocorticoid Receptor, lymphocyte 2908 2.202243881 3.5E-08 1.694016378 1.871546701 39032_at TGFP-stimulating protein (regulates C-type natriuretic peptide gene) 8848 -2.226498199 2.04E-07 -2.979839304 -1.851582699 32034-at Krnppel-like transcription factor 7764 2.247161582 9.04E- 07 2.1386648 1.611108294 287_at activated transcription factor 3 467 4.037944598 0.00021361 5.867934682 2.449017154 3 7419-g-at POU functional site, category 2, transcription factor 2 5452 3.570311319 8.54E-07 10.2030961 7.279581414 3 7417-at POU functional site, category 2 , Transcription factor 2 5452 3.15917466 1.82E-09 6.743320713 3.658601746 943_at runt-related transcription factor i 861 3.123404286 3.88E-11 2.595679083 2.208405598 393_s_at rum-related transcription factor! 861 2.718511505 5.28E-07 2.094702547 1.753450444 39421 a at rum-related transcription factor as early as 1 861 2.330472883 1.54E-08 2.842674795 1.989573274 535_s_at NFKB2 (p49 / pl〇〇) _ 4791 7.014437801 8.77E-09 12.09195342 6.581215622 40823_s_at Transcription factor N 4775 2.078620759 0.00095663 -1.45270611 -1.629367546 33130 one at source box D1 3231 -5.00861908 3.68E-08 -2.579094814 -5.352803906 35824_at Welding finger protein 238 10472 -2.383931066 6.72E-07 -4.13316475 -3.964515214 32034_at Fresh finger protein 217… 7764 2.247161 9.04E-07 2.1386648 1.611108294 3968 l_at Fresh finger protein 145 (Krupple-like) 7704 2.477517897 0.00000829 1.736511126 1.220799652 41612_at Zinc finger protein 264 9422 4.296329969 0.0000447 -1.079860264 -6.156102305 39633_at S100 mom binding protein A3 6274 2.829339235 0.00162186 4.49571209 Germ layer homeobox 1 5396 3.283107586 0.00034973 10.49393725 6.156341582 40199_at msh homeobox 1 (Drosophila) 4487 2.409909357 0.0000071 2.52190312 1 2.708781174 215—g_at msh homeobox 4487 2.329390033 0.0002391 3.803589095 7.060846295 98677.doc -41-200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 1(果蠅） 酵素 34304_s_at 亞精胺Nl-乙醯轉移酶 (多元胺分解代謝） 6303 6.704420999 6.44E-15 3.431292345 4.27011499 1173_g_at 亞精胺/精胺N1-乙醯 轉移酶，Alt.接合2 — 4.132527389 0 2.917946858 3.523924496 1069 at COX-2 --- 34.72962658 0 60.94542155 124.409157 33862_at 磷酯酸脫磷酸酯酶 2B型 8613 3.214894884 2.78E-13 3.604930643 3.689974385 34666 at Mn SOD 6648 21.14199305 0 41.56950623 36.7453472 39640_at 榖胺醯胺-果糖-6-破酸 轉胺酶2(己糖胺生物 合成） 9945 5.640667138 2.42E-14 5.982698011 8.612059352 40215_at UDP-葡萄糖神經醯胺 葡萄糖基轉移酶 7357 4.897679713 0 3.893723735 4.931113889 41352一 at P-半乳糖苷α-2,6_唾液 基轉移酶(糖基化作用） 6480 5.993191486 0 3.047035442 4.933917672 34390一 at 脯胺酸4-羥化酶α多 肽Π 8974 3.99041836 5.55E-16 5.868560288 4.278419323 40290_f_at Ρ-半乳糖苷α-2,3-唾液 基轉移酶(糖基化作用） 6482 6.686428065 9.24E-12 4.85511756 2.420407432 576一at NO合成酶 4846 -10.63785461 0 -13.32725039 -5.923096431 3 7402一 at RNA酶1，胰臟的 6035 -4.245955517 1.46E-10 -5.030206449 -6.634617447 3 8066一at 心肌黃酶 (NADH/NADPH)(細胞 色素b-5還原酶） 1728 -2.415151638 6.38E-09 -1.305264296 -3.114333412 36658—at 3-β-羥類固醇δ·24-還原 酶(膽固醇生物合成） 1718 -2.643697649 9.12E-12 -2.593239368 -3.836044468 40568_at ΑΤΡ酶，Η+傳遞，溶 酶體的 526 2.371659873 4.34E-11 3.188827679 2.637705921 33707_at 破脂酶Α2γ(細胞溶質 的） 8605 3.261679914 3.69E-11 3.522257814 2.301935515 34876_at 羧基肽酶D 1362 3.076753085 1.94E-10 2.897736214 3.000177375 231一at 轉榖胺醯胺酶2(交聯 蛋白質） 7052 -2.617617679 8.12E-14 -3.334570859 -2.678284178 35938一at 磷脂酶Α2(細胞溶質 的，約-依賴性的） 5321 3.619599149 3.8E-13 2.366489356 3.253061315 38129一at 甘油激酶(使内源和飲 食中的甘油代謝） 2710 4.156535178 2.03E-11 4.389062428 4.783183323 40671一 g一at L-犬尿胺酸水解酶(色 胺酸代謝） 8942 19.54992096 7.83E-13 31.92023266 35.93860554 41654_at 腺苷脫胺酶 100 2.826089391 3.24E-10 3.599789192 3.713396127 3 3 802—at 血紅素加氧酶1 3162 -3.426190665 1.24E-08 1.138813035 -3.346040419 37015_at 链脫氫酶1，可溶的 216 -4.815533737 1.08E-13 -7.171622822 -5.357724575 36149_at 類二氫嘧啶酶3 1809 2.348831769 2.55E-10 1.790570365 2.165038959 32718—at 路胺醯基蛋白質磺基轉 移酶1(在炎症時修改 蛋白質） 8460 2.226480677 3.24E-07 1.761306768 2.35714199 41656_at Ν-肉苴蔻醯基轉移酶2 9397 -2.01967345 5.85E-09 -2.434231443 -3.519602144 1227_g_at TNFa轉化酶 6868 3.813351746 5.27E-09 1.452030457 5.668869009 41601_at iNFa轉化酶 6868 2.795464504 4.04E-09 1.860860363 2.545861043 3 9663一at 甘露苷酶a，2A類， 成員1(高爾基氏體酵 素） 4124 2.172987708 1.64E-09 2.83218502 2.31 0898922 37944_at GTP環水解酶U多巴- 2643 4.438893651 1.75E-09 14.75969444 8.812737944 98677.doc -42 - 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = 1) MVEC FC (n = 1) 1 (Drosophila) Enzyme 34304_s_at Spermidine Nl-acetamidine transferase Amine catabolism) 6303 6.704420999 6.44E-15 3.431292345 4.27011499 1173_g_at Spermidine / spermine N1-acetamidine transferase, Alt. Conjugation 2 — 4.132527389 0 2.917946858 3.523924496 1069 at COX-2 --- 34.72962658 0 60.94542155 124.409157 33862_at Phosphate Acid Dephosphatase 2B Type 8613 3.214894884 2.78E-13 3.604930643 3.689974385 34666 at Mn SOD 6648 21.14199305 0 41.56950623 36.7453472 39640_at Pyridoxamine-fructose-6-deacid transaminase 2 (hexosamine biosynthesis) 9945 5.640667138 2.42 E-14 5.982698011 8.612059352 40215_at UDP-gluconeuraminyl glucosyltransferase 7357 4.897679713 0 3.893723735 4.931113889 41352-at P-galactosyl α-2,6_sialyltransferase (glycosylation) 6480 5.993191486 0 3.047035442 4.933917672 34390-at proline 4-hydroxylase alpha peptide Π 8974 3.99041836 5.55E-16 5.868560288 4.278419323 40290_f_ at P-galactoside α-2,3-sialyltransferase (glycosylation) 6482 6.686428065 9.24E-12 4.85511756 2.420407432 576-at NO synthetase 4846 -10.63785461 0 -13.32725039 -5.923096431 3 7402-at RNAse 1. Pancreas 6035 -4.245955517 1.46E-10 -5.030206449 -6.634617447 3 8066-at myocardial enzyme (NADH / NADPH) (cytochrome b-5 reductase) 1728 -2.415151638 6.38E-09 -1.305264296 -3.114333412 36658— at 3-β-hydroxysteroid δ · 24-reductase (cholesterol biosynthesis) 1718 -2.643697649 9.12E-12 -2.593239368 -3.836044468 40568_at ATPase, Η + delivery, lysosomal 526 2.371659873 4.34E-11 3.188827679 2.637705921 33707_at Lipase A2γ (cytosolic) 8605 3.261679914 3.69E-11 3.522257814 2.301935515 34876_at Carboxypeptidase D 1362 3.076753085 1.94E-10 2.897736214 3.000177375 231-at Transaminase 2 (Crosslinked Protein) 7052 -2.617617679 8.12E -14 -3.334570859 -2.678284178 35938-at phospholipase A2 (cytosolic, about-dependent) 5321 3.619599149 3.8E-13 2.366489356 3.253061315 381 29-at glycerol kinase (metabolizes glycerol in endogenous and diet) 2710 4.156535178 2.03E-11 4.389062428 4.783183323 40671-g at L-kynurenine hydrolase (tryptophan metabolism) 8942 19.54992096 7.83E-13 31.92023266 35.93860554 41654_at adenosine deaminase 100 2.826089391 3.24E-10 3.599789192 3.713396127 3 3 802-at heme oxygenase 1 3162 -3.426190665 1.24E-08 1.138813035 -3.346040419 37015_at chain dehydrogenase 1, soluble 216 -4.815533737 1.08 E-13 -7.171622822 -5.357724575 36149_at dihydropyrimidinase 3 1809 2.348831769 2.55E-10 1.790570365 2.165038959 32718—at glutamyl protein sulfotransferase 1 (modify protein during inflammation) 8460 2.226480677 3.24E-07 1.761306768 2.35714199 41656_at Ν-Myristoyltransferase 2 9397 -2.01967345 5.85E-09 -2.434231443 -3.519602144 1227_g_at TNFa converting enzyme 6868 3.813351746 5.27E-09 1.452030457 5.668869009 41601_at iNFa converting enzyme 6868 2.795464504 4.04E-09 1.860860363 2.545861043 3 9663-at Mannosidases a, 2A, member 1 (Golgi enzyme) 4124 2.172987708 1.64E-09 2.83218502 2.31 0898922 37944_at GTP cyclohydrolase Udopa-2643 4.438893651 1.75E-09 14.75969444 8.812737944 98677.doc -42-200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 反應性肌張力不全 (dystonia)，NO 合成） 40672一 at L-犬尿胺酸水解酶(涉 及輔因子之生物合成） 8942 2.673122374 4.73E-10 3.563621638 4.441970617 38463_s_at 腺苷單磷酸脫胺酶，紅 血球同功型 272 3.252956552 0.0000363 4.881773924 2.28032833 40505_at 泛素•共軛酵素E2L6 9246 2.260319502 0.00000441 6.11613235 1.848697939 38315_at 視黃醛脫氫酶2 8854 -3.141750466 8.22E-10 -1.56562427 ，1.111060049 3426 l_at 磷酸胞苷轉移酶2，乙 醇胺 5833 -2.168441607 2.43E-07 -2.495275565 -3.137010475 1226_at TNFa轉化酶 6868 2.300272424 0.00000707 1.004340971 2.756217115 37255_at N-脫乙醯酶/N-續基轉 移酶(乙醯肝素葡糖胺 基)2 8509 2.216017066 0.0000592 2.306019166 1.291774578 3 5396一at 透明質酸(hyaluronan) 合成酶2 3037 4.945257021 0.0000787 1.000129624 3.057807352 37608_g__at 酮己糖激酶(ketohexo-kinase)(果糖激酶） 3795 -2.946029683 0.0000001 -2.552822874 -1.840790023 35702_at 羥類固醇(ll-β)脫氩酶 1 3290 5.464059097 2.13E-07 4.384698173 7.735231534 1212 一 at 榖胱甘肽轉移酶ζΐ(順 丁烯二醯基乙醯乙酸鹽 異構酶） 2954 2.588622881 1.25E-07 1.930737369 1.42606759 3 9791一 at ΑΤΡ酶，Ca#運載，心 肌，慢痙攣2 488 2.012343217 〇.〇〇〇〇〇〇04 1.822188224 2.032942103 40214一 at UDP-葡萄糖神經醯胺 葡萄糖基轉移酶 7357 4.72644372 7.22E-09 3.81 4508262 4.080889627 41711_at 硫氧化還原蛋白還原酶2 10587 -2.948650383 2.67E-08 -6.378914918 -8.72831537 35966—at 榖胺醯胺醯基-肽環轉 移酶(cyclotransferase) (榖胺醯胺醯基環化酶 (cyclase)) 25797 2.328202379 3.18E-08 2.329644161 2.391292262 —32772—s一 at UDP-Gal：PGlcNAc β 1，4-半乳糖基轉移酶， 多肽1 2683 4.456181198 0.0000175 1.238263347 1.497110144 39107一at 羊毛S醇合成酶(2,3·氧 化鯊婦(oxidosqualene)-羊毛留醇環化酶） 4047 3.358766219 0.00073095 1.390518246 .534806813 3 463 6一at 花生四烯酸鹽15-脂肪 氧合酶 246 2.440589489 0.00067786 2.682402797 4.947969996 40670一 at 犬尿楂琳酸(L-犬尿胺 酸水解酶） 8942 7.008740575 0.00043779 1.470999146 1.901287336 3784 l_at 丁醯膽鹼酯酶 590 -4.246686347 0.0000456 1.724782943 -1.270228337 712_s_at 絲胺酸羥甲基轉移酶， 細胞溶質的，Alt.接合3 … -2.610161222 0.000031 -1.94665557 -2.625365856 "34209_at 肌醇1，4,5-三磷酸3-激 酶C 80271 2.90950996 0.00040388 3.289484052 -1.391614528 19267一 at 磷酸葡萄糖變位酶3 5238 2.053010541 0.00000242 1.904710164 1.542414689 細胞週期調節 "37218_at BTG3 (細胞增殖之陰性 對照組） 10950 2.624092795 2.45E-10 3.856424559 3.197893027 15153 at P95(nibrin) 4683 2.136220929 2.84E-09 2.994019488 2.441142021 T25 at P27 3429 2.762082411 3.66E-09 2.627038307 1.886894848 1207一 at 週期素·依賴性激酶6 1021 2.455451672 0.0000135 -1.062090681 1.219554564 98677.doc •43- 200533758Probe set description Site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) Reactive Dystonia (NO synthesis) 40672-at L-dog Uric acid hydrolase (biosynthesis involving cofactors) 8942 2.673122374 4.73E-10 3.563621638 4.441970617 38463_s_at Adenosine monophosphate deaminase, red blood cell isoform 272 3.252956552 0.0000363 4.881773924 2.28032833 40505_at ubiquitin • conjugated enzyme E2L6 9246 2.260319502 0.00000441 6.11613235 1.848697939 38315_at retinal dehydrogenase 2 8854 -3.141750466 8.22E-10 -1.56562427, 1.111060049 3426 l_at cytosine transferase 2, ethanolamine 5833 -2.168441607 2.43E-07 -2.495275565 -3.137010475 1226_at TNFa converting enzyme 6868 2.300272424 0.00000707 1. 2.756217115 37255_at N-deacetylase / N-continyltransferase (ethanoheparin glucosamine) 2 8509 2.216017066 0.0000592 2.306019166 1.291774578 3 5396-at hyaluronan synthase 2 3037 4.945257021 0.0000787 1.000129624 3.057807352 37608_g___one ketone Ketohexo-kinase (fructokinase) 3795 -2.946029683 0.0000001 -2.552822874 -1.840790023 35702_at hydroxysteroid (ll-β) dearginase 1 3290 5.464059097 2.13E-07 4.384698173 7.735231534 1212 one at 榖 Glutathione transferase ζΐ (cis-butenyl diethylacetate acetate isoisocyanate (Constructive enzyme) 2954 2.588622881 1.25E-07 1.930737369 1.42606759 3 9791-at ATPase, Ca # carrying, myocardial, slow cramps 2 488 2.012343217 〇.〇〇〇〇〇〇04 1.822188224 2.032942103 40214-at UDP-glucosamine neuroglucosamine glucose Base transferase 7357 4.72644372 7.22E-09 3.81 4508262 4.080889627 41711_at thioredoxin reductase 2 10587 -2.948650383 2.67E-08 -6.378914918 -8.72831537 35966-at pyrimidine amidino-peptide ring transferase (cyclotransferase) (榖Aminamine cyclase) 25797 2.328202379 3.18E-08 2.329644161 2.391292262 —32772-s-at UDP-Gal: PGlcNAc β 1,4-galactosyltransferase, peptide 1 2683 4.456181198 0.0000175 1.238263347 1.497110144 39107 1 at wool S alcohol synthase (2,3 · oxidosqualene-lanosterol cyclase) 4047 3.35 8766219 0.00073095 1.390518246 .534806813 3 463 6-at arachidonic acid 15-lipoxygenase 246 2.440589489 0.00067786 2.682402797 4.947969996 40670-at canine ursin (L-kynuurease) 8942 7.008740575 0.00043779 1.470999146 1.901287336 3784 l_at Butylcholinesterase 590 -4.246686347 0.0000456 1.724782943 -1.270228337 712_s_at Serine hydroxymethyltransferase, cytosolic, Alt. Conjugation 3… -2.610161222 0.000031 -1.94665557 -2.625365856 " 34209_at Inositol 1,4,5 -Triphosphate 3-kinase C 80271 2.90950996 0.00040388 3.289484052 -1.391614528 19267-at Glucose mutase 3 5238 2.053010541 0.00000242 1.904710164 1.542414689 Cell cycle regulation " 37218_at BTG3 (negative control group for cell proliferation) 10950 2.624092795 2.45E-10 3.856424559 3.197893027 15153 at P95 (nibrin) 4683 2.136220929 2.84E-09 2.994019488 2.441142021 T25 at P27 3429 2.762082411 3.66E-09 2.627038307 1.886894848 1207-at cyclin-dependent kinase 6 1021 2.455451672 0.000013 5 -1.062090681 1.219554564 98677.doc • 43- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 40399_r_at 間質同源異形盒2(生 長妨礙-專一的同源異 形盒） 4223 -2.245407634 0.00018939 -1.677937769 1.360368999 38326_at 假設的淋巴細胞G0/G1 轉換基因 50486 5.210351552 9.34E-07 4.501028149 2.835700322 細胞通訊 3253 l_at 間隙連接蛋白43 (connexin) 2697 2.368387646 2.65E-11 1.97846913 2.001682474 2018一at 間隙連接蛋白43 2697 3.031077047 1.69E-07 2.474557415 2.815825621 40687_at 間隙接合蛋白質，α4， 37kDa(間隙連接蛋白 37) 2701 -5.56891197 0.0000116 -3.025458771 -2.091117495 核蛋白 37027_at AHNAK核蛋白(橋粒 聯結蛋白(desmoyokin)) 195 -2.16666252 1.49E-09 -2.455018307 -3.26541786 286一 at H2A組織蛋白家族， 成員0 8337 3.115339124 7.26E-09 4.90449378 3.960532543 37354一 at 核抗原Sp 1〇〇 6672 3.058654921 1.07E-07 2.643890811 1.040688287 32609—at H2A組織蛋白家族， 成員0 8337 15.67613628 9.49E-10 13.14154378 5.736367488 39397_at 核受鳢亞家族2，F 組，成員2 7026 -2.044215909 1.98E-09 -2.272605283 -2.260646545 37377丄 at 核纖層蛋白 (lamin)A/C(核發育的結 構蛋白質） 4000 -2.350943533 1.75E-10 -2.555422079 -1.767515468 33249一 at 核受體亞家族3，C 組，成員2 4306 -2.584848636 3.41E-08 -1.739378234 -1.562212566 34690一 at SWI/SNF相關之亞家 族c，成員2 6601 -2.088814752 0.00000536 -1.565957305 -1.282789174 32668_at 單股DNA結合蛋白質 2 23635 -3.149577521 0.00031465 -1.640548596 -2.145738917 細胞骨架 41439一at 肌球蛋白第I類(突變 的對偶基因） 4430 9.740468685 2.06E-10 14.70291906 10.25673133 33102 at 内收蛋白(adducin)3(Y) 120 3.391355995 1.1E-12 6.424336776 3.508692997 34082_at 彈弓(slingshot) 1(F-肌動 蛋白結合） 54434 2.484987537 2.07E-10 1.636955316 1.21353576 3 6792一at 原肌球蛋白1(a) 7168 2.572958966 2.38E-11 1.214714872 1.819080175 3 6790一at 原肌球蛋白1(〇〇 7168 2.209718995 4.39E-10 1.104623941 1.666863013 3 5 766一 at 角蛋白18 3875 -4.242007604 2.68E-14 -4.656673789 -6.504888937 36791_g_at 原肌球蛋白1(〇〇 7168 2.9249265 8.61E-13 1.468402341 1.880703517 33103一s 一 at 内收蛋白3(γ) 120 3.920756358 2.92E-10 6.031570788 3.575830825 37785一 at RH06GTP-結合蛋白 質(?肌動蛋白細胞骨架 調節） 27289 4.221025029 2.48E-12 1.273849496 7.406673709 39070一at 菲辛(fascin)(肌動蛋白-結合蛋白質） 6624 -2.330745344 6.37E-13 -1.68300774 •2.694414931 35803—at ras同系物基因家族， 成員E(肌動蛋白緊迫 纖維的拆解） 390 -2.233636127 2.29E-10 -1.055779002 1.038111944 34886一at 根蛋白(radixin) 5962 2.420953001 1.22E-07 1.584145112 1.542677121 986^7^00 -44- 200533758HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 40399_r_at Interstitial homeobox 2 ) 4223 -2.245407634 0.00018939 -1.677937769 1.360368999 38326_at Hypothesized lymphocyte G0 / G1 switch gene 50486 5.210351552 9.34E-07 4.501028149 2.835700322 Cell communication 3253 l_at gap connexin 43 (connexin) 2697 2.368387646 2.65E-11 1.97846913 2.001682474 2018-at gap junction Protein 43 2697 3.031077047 1.69E-07 2.474557415 2.815825621 40687_at gap junction protein, α4, 37kDa (gap junction protein 37) 2701 -5.56891197 0.0000116 -3.025458771 -2.091117495 nuclear protein 37027_at AHNAK nuclear protein (desmoyokin) 195 -2.16666252 1.49E-09 -2.455018307 -3.26541786 286-at H2A tissue protein family, members 0 8337 3.115339124 7.26E-09 4.90449378 3.960532543 37354-at nuclear antigen Sp 1〇6672 3.058654921 1.07E-07 2.643890811 1.040688287 32609-at H2A tissue protein family , Member 0 8337 15.67613628 9.49E-10 13.14154378 5.736367488 39397_at Nuclear subtype family 2, group F, member 2 7026 -2.044215909 1.98E-09 -2.272605283 -2.260646545 37377 丄 at nuclear lamin A / C (nuclear development Structural protein) 4000 -2.350943533 1.75E-10 -2.555422079 -1.767515468 33249-at nuclear receptor subfamily 3, group C, member 2 4306 -2.584848636 3.41E-08 -1.739378234 -1.562212566 34690-at SWI / SNF related subgroup Family c, member 2 6601 -2.088814752 0.00000536 -1.565957305 -1.282789174 32668_at single-stranded DNA binding protein 2 23635 -3.149577521 0.00031465 -1.640548596 -2.145738917 cytoskeleton 41439-at myosin type I (mutated dual gene) 4430 9.740468685 2.06E- 10 14.70291906 10.25673133 33102 at Adducin 3 (Y) 120 3.391355995 1.1E-12 6.424336776 3.508692997 34082_at Slingshot 1 (F-actin binding) 54434 2.484987537 2.07E-10 1.636955316 1.21353576 3 6792-at original Myosin 1 (a) 7168 2.572958966 2.38E-11 1.214714872 1.81908017 5 3 6790-at tropomyosin 1 (〇007168 2.209718995 4.39E-10 1.104623941 1.666863013 3 5 766-at keratin 18 3875 -4.242007604 2.68E-14 -4.656673789 -6.504888937 36791_g_at tropomyosin 1 (〇〇168168 2.9249265 8.61E-13 1.468402341 1.880703517 33103 one s one at adduct 3 (γ) 120 3.920756358 2.92E-10 6.031570788 3.575830825 37785 one at RH06GTP-binding protein (? Actin cytoskeleton regulation) 27289 4.221025029 2.48E-12 1.273849496 7.406673709 39070-fascin (actin-binding protein) 6624 -2.330745344 6.37E-13 -1.68300774 • 2.694414931 35803—at ras homolog gene family, member E (disassembly of actin pressing fibers) 390 -2.233636127 2.29E-10 -1.055779002 1.038111944 34886-at root protein (radixin) 5962 2.420953001 1.22E-07 1.584145112 1.542677121 986 ^ 7 ^ 00 -44- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 3 488 7一at 根蛋白（交聯肌動蛋白· 和嵌入膜蛋白質） 5962 2.278449836 6.64E-08 1.199811512 1.794183039 32847_at 肌球蛋白輕鏈激酶 4638 4.896958824 9.13E-09 18.11380806 2.725943964 40069_at 超域毛蛋白(supervillin) 6840 2.682759032 0.0000725 3.169652491 2.028055227 1058_at 肌動蛋白·與細 胞骨架有關） 10810 -2.097291681 1.68E-07 -1.631969908 -3.144102457 3 8022一 s一 at 蜗)蛋白(plectin)l，中間 絲結合蛋白質500kDa 5339 -2.557004064 0.0000137 -4.301607614 -3.040635806 40899_at 角蛋白19 3880 -6.322934628 1.59E-09 -13.66744481 -8.25383859 41294__at 角蛋白7 ' 3855 -4.318997454 0.0000126 -7.499352182 -6.560418569 補體 37388一at 砠纖因子路徑抑制劑2 7980 23.78384351 2.22E-13 5.35937334 33.8370157 35664_at 爹聚素(multimerin) 22915 -3.742143256 1.5E-14 -9.087085855 -4.496252381 36345_g_at 類凝固因子11(凝血酶） 受體1 2150 2.846565472 7.74E-08 4.471805084 4.865728749 39409_at 補體組份1 715 5.781697808 0.00000211 13.33715147 6.459955952 3 6344一at 類凝固因子11(凝血酶） 受體1 2150 5.790500377 1.15E-12 6.773344893 4.683025515 17185 at "PAI-2~~' 5055 3.441 427028 0.00000796 3.324772251 1.431092156 338〇3_at 凝企酶調節素 (thrombomodulin) — -4.010890247 6.01 E-11 -4.187934083 -2.823656854 T5822_at B-因子，備解素 629 3.628127319 5.92E-07 19.71747326 3.665782889 lO496_at 補體組份1，s亞組份 716 5.442703249 0.00000145 27.82653223 13.55862174 lT825_at 絲胺酸(或半胱胺酸)蛋 白酶抑制劑，支系D 成員1 3053 3.710911406 1.09E-07 2.145669759 1.468699812 l6543_at 凝固因子瓜(促凝血酶 原激酶，組織因子） 2152 9.446520842 0.0000041 8.829602345 9.990355775 ^295 at DARC 2532 3.201933176 0.00000869 4.74993939 2.160165669 i胞外基質 l9333_at 每原蛋白，第IV型，αΐ — 3.294038599 1.4E-10 2.248373685 2.640671802 *3255 l_at 類含EGF之細胞微絲 (fibulin)的細胞外基質 蛋白質1 2202 -2.645292659 6.16E-10 -3.672557726 -4.730137915 "36929^at 昆布胺酸，03(125kD) 3914 4.113164884 3.73E-12 8.332528001 5.436782952 l6659^at 膠原蛋白，第IV型，α2 1284 2.336145488 4.11E-10 2.675850693 2.28281283 "J5366_at 巢蛋白(nidogen)(安納 /'T(enactin)) 4811 -2.021024484 0.0000047 -2.914727592 -3.017493076 ^3528°-at 昆布胺酸，γ2 3918 10.39471638 0.0000158 3.017362805 15.60150516 "37459_at 膠原蛋白，第Μ型，αΐ 1295 3.050351654 0.0000017 3.148028315 5.176396595 12818_at 腱生蛋白(tenascin)C(海 薩布群(hexabrachion)) 3371 44.41053365 0.0000080 4.803724568 5.681119838 "35l68_f_at 膠原蛋白，第XVI型， αΐ 1307 7.746991041 0.00000406 11.09936614 5.956620288 白質及其他受體 l2U4_s_at G-蛋白質·偶聯受體 (A2a受體） 135 7.585528941 0 8.109402646 8.790666973 ^34288_at 孤兒G蛋白質-偶聯受 體 57007 8.088266305 4.55E-15 27.11397321 30.67795921 "l8247_at 孤兒G蛋白質-偶聯受 體 2150 6.820758815 3.54E-10 8.161820702 7.968953316 98677.doc -45 - 200533758Probe set description sites connected to HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 3 488 7-at root protein (cross-linked actin · and embedded membrane protein ) 5962 2.278449836 6.64E-08 1.199811512 1.794183039 32847_at Myosin Light Chain Kinase 4638 4.896958824 9.13E-09 18.11380806 2.725943964 40069_at Supervillin 6840 2.682759032 0.0000725 3.169652491 2.028055227 1058_at Actin · Related to the cytoskeleton 911 10810 -2.0 1.68E-07 -1.631969908 -3.144102457 3 8022-s-at lectin), intermediate filament binding protein 500kDa 5339 -2.557004064 0.0000137 -4.301607614 -3.040635806 40899_at keratin 19 3880 -6.322934628 1.59E-09 -13.66744481 -8.25383859 41294__at Keratin 7 '3855 -4.318997454 0.0000126 -7.499352182 -6.560418569 Complement 37388-at Fibrillin pathway inhibitor 2 7980 23.78384351 2.22E-13 5.35937334 33.8370157 35664_at multimerin 22915 -3.742143256 1.5E-14 -9.087085855 -4.496252381 36345_g_at coagulation factor 11 (coagulation Enzyme) receptor 1 2150 2.846565472 7.74E-08 4.471805084 4.865728749 39409_at complement component 1 715 5.781697808 0.00000211 13.33715147 6.459955952 3 6344-at coagulation factor 11 (thrombin) receptor 1 2150 5.790500377 1.15E-12 6.773344893 4.683025515 17185 at " PAI-2 ~~ '5055 3.441 427028 0.00000796 3.324772251 1.431092156 338〇3_at thrombomodulin — -4.010890247 6.01 E-11 -4.187934083 -2.823656854 T5822_at B-factor, protease 629 3.628127319 5.92E-07 19.71747326 3.665782889 lO496_at complement component 1, s subcomponent 716 5.442703249 0.00000145 27.82653223 13.55862174 lT825_at serine (or cysteine) protease inhibitor, branch D member 1 3053 3.710911406 1.09E-07 2.145669759 1.468699812 l6543_at coagulation factor melon (procoagulant Enzyme protokinase, tissue factor) 2152 9.446520842 0.0000041 8.829602345 9.990355775 ^ 295 at DARC 2532 3.201933176 0.00000869 4.74993939 2.160165669 i Extracellular matrix 19333_at per proprotein, type IV, αΐ — 3.294038599 1.4E-10 2 .248373685 2.640671802 * 3255 l_at extracellular matrix protein containing EGF-containing cell microfilaments (fibulin) 1 2202 -2.645292659 6.16E-10 -3.672557726 -4.730137915 " 36929 ^ at kubumic acid, 03 (125kD) 3914 4.113164884 3.73E -12 8.332528001 5.436782952 l6659 ^ at collagen, type IV, α2 1284 2.336145488 4.11E-10 2.675850693 2.28281283 " J5366_at nidogen (Anna / 'T (enactin)) 4811 -2.021024484 0.0000047 -2.914727592 -3.017493076 ^ 3528 ° -at Kunbunic acid, γ 2 3918 10.39471638 0.0000158 3.017362805 15.60150516 " 37459_at collagen, type M, αΐ 1295 3.050351654 0.0000017 3.148028315 5.176396595 12818_at tenascin C (hexabrachion) 3371 44.41053365680 0.00 5.681119838 " 35l68_f_at collagen, type XVI, αΐ 1307 7.746991041 0.00000406 11.09936614 5.956620288 white matter and other receptors l2U4_s_at G-protein · coupled receptor (A2a receptor) 135 7.585528941 0 8.109402646 8.790666973 ^ 34288_at orphan G protein Mass-coupled receptor 57007 8.088266305 4.55E-15 27.11397321 30.67795921 " 18247_at orphan G protein-coupled receptor 2150 6.820758815 3.54E-10 8.161820702 7.968953316 98677.doc -45-200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 32115_r_at G蛋白質-偶聯受體 (A2a受體） 135 3.353944077 1.11E-10 7.275228636 9.470302722 1105_s_at T細胞受體β位點 — -2.885206906 7.15E-12 -1.709061111 -1.489399158 37645一at CD69(細胞表面糖蛋白） 969 4.1627256 9.18E-08 4.927757479 4.51 551 4511 39310_at 舒緩激肽受體B2 624 5.506990833 8.25E-11 21.40768199 26.48656094 40310_at 類鐸受體2 7097 17.04231159 6.34E-08 41.69446428 92.69458196 33764_at G蛋白質-偶聯受體51 9568 -4.114163378 7.43E-08 -6.496935914 -5.999971299 40240一at G蛋白質-偶聯受體， C5B 51704 3.405092443 3.75E-08 2.244472511 3.779946146 41831_at 低密度脂蛋白受體-相 關蛋白質5 4041 -2.020184601 0.00000334 -2.92443917 -1 .967658837 41831_at 低密度脂蛋白受體-相 關蛋白質5 4041 -2.020184601 0.00000334 -2.92443917 -1 .967658837 36059_at 低密度脂蛋白受體-相 關蛋白質4 4038 2.167124662 0.00049742 1.712017357 1.571062091 33236_at 視黃酸受體反應劑 (tazarotene 誘發） 5920 2.254357183 0.000037 2.573139814 1.387068386 33772一at ***素E受體4(亞 型 EP4) 5734 -2.821392903 0.00000285 -3.33146064 -5.979710428 706_at 糖皮質激素受體，P — 2.732594537 0.00000824 1.92549503 2.243726671 38222_at 嘧啶能的受體P2Y， G-蛋白質偶聯的，6 5031 5.12709451 0.00050913 5.150230333 •1.000345091 37534_at 柯薩奇病毒和腺病毒受 體 1525 -7.953355635 6.94E-07 -10.03852045 -6.352677218 34975一at 類殺手細胞外源凝集素 受體亞家族G，成員1 10219 -7.631896619 0.0000201 -3.597564002 -1.580902467 干擾素-可誘導之基因 33304_at 干擾素刺激之基因 (20kD) 3669 6.368043453 6.66E-16 21 .37131919 8.654897863 41140一at 干擾素γ受體2 3460 3.843792475 3E-15 6.009122949 4.473233377 32700_at 鳥嘌呤核苷酸結合蛋白 質2 2634 3.552701285 1.08E-10 4.864506689 2.105432487 464_s_at 干擾素-誘導之蛋白質 35 3430 2.673886964 3.22E-08 9.148025083 3.018968778 39728_at 干擾素，γ·可誘導之蛋 白質30 10437 5.774728675 3.99E-07 14.1357142 14.8277104 425一 at 干擾素，CX-可誘導之蛋 白質27 3429 2.762082411 3.66E-09 2.627038307 .886894848 925_at 干擾素，γ-可誘導之蛋 白質30 10437 7680903539 1.26E-12 13.2183993 9.629877375 35735一at 烏嘌呤核苷酸結合蛋白 質1 2633 2.943798001 3.26E-09 6.637940419 4.567149794 626_s_at 干擾素-可誘導之蛋白 質35 3430 2.126602914 2.81E-07 9.365638399 2.209101255 38584—at 干擾素-可誘導之蛋白 質具有肽重複段4 3437 2.968612864 0.00000601 19.75380759 2.995063164 蛋白酵體系統 __ 41171_at 蛋白酵體活化劑次單元2 5721 2.632747876 2.94E-08 5.101785113 3.339110072 1184 一 at 蛋白酵體活化劑次單元 2，Ρ 5721 3.562723482 1.92E-12 4.791072135 2.802359636 3 84一 at 蛋白酵體次單元，β-型 10 5699 3.877228796 4.1E-14 5.603185012 3.630961741 38287_at 蛋白酵艘次單元，β·型 9 5698 4.659894959 4.78E-08 7.535678146 2.324895346 98677.doc -46- 200533758Probe set description site connected to HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 32115_r_at G protein-coupled receptor (A2a receptor) 135 3.353944077 1.11E- 10 7.275228636 9.470302722 1105_s_at T-cell receptor beta site--2.885206906 7.15E-12 -1.709061111 -1.489399158 37645-at CD69 (cell surface glycoprotein) 969 4.1627256 9.18E-08 4.927757479 4.51 551 4511 39310_at bradykinin receptor B2 624 5.506990833 8.25E-11 21.40768199 26.48656094 40310_at Tudor-like receptor 2 7097 17.04231159 6.34E-08 41.69446428 92.69458196 33764_at G protein-coupled receptor 51 9568 -4.114163378 7.43E-08 -6.496935914 -5.999971299 40240 one at G protein-coupled receptor Body, C5B 51704 3.405092443 3.75E-08 2.244472511 3.779946146 41831_at low density lipoprotein receptor-related protein 5 4041 -2.020184601 0.00000334 -2.92443917 -1 .967658837 41831_at low density lipoprotein receptor-related protein 5 4041 -2.020184601 0.00000334 -2.92443917- 1 .967658837 36059_at low density lipoprotein receptor-related protein 4 4038 2.167124662 0.00049742 1.7120173 57 1.571062091 33236_at Retinoic acid receptor reactant (induced by tazarotene) 5920 2.254357183 0.000037 2.573139814 1.387068386 33772-at prostaglandin E receptor 4 (subtype EP4) 5734 -2.821392903 0.00000285 -3.33146064 -5.979710428 706_at glucocorticoid receptor, P — 2.732594537 0.00000824 1.92549503 2.243726671 38222_at Pyrimidine receptor P2Y, G-protein-coupled, 6 5031 5.12709451 0.00050913 5.150230333 • 1.000345091 37534_at Coxsackie virus and adenovirus receptor 1525 -7.953355635 6.94E-07 -10.03852045 -6.352677218 34975-at Killer-like cell exogenous lectin receptor subfamily G, member 1 10219 -7.631896619 0.0000201 -3.597564002 -1.580902467 Interferon-inducible gene 33304_at Interferon-stimulated gene (20kD) 3669 6.368043453 6.66E-16 21 .37131919 8.654897863 41140 -At interferon gamma receptor 2 3460 3.843792475 3E-15 6.009122949 4.473233377 32700_at guanine nucleotide binding protein 2 2634 3.552701285 1.08E-10 4.864506689 2.105432487 464_s_at interferon-induced protein 35 3430 2.673886964 3.22E-08 9.148025083 3.018968778 39728_at interferon, gamma-inducible protein 30 10437 5.774728675 3.99E-07 14.1357142 14.8277104 425-at interferon, CX-inducible protein 27 3429 2.762082411 3.66E-09 2.627038307 .886894848 925_at interferon, γ-inducible protein 30 10437 7680903539 1.26E-12 13.2183993 9.629877375 35735 one at uridine nucleotide binding protein 1 2633 2.943798001 3.26E-09 6.637940419 4.567149794 626_s_at interferon-inducible protein 35 3430 2.126602914 2.81 E-07 9.365638399 2.209101255 38584-at interferon-inducible protein with peptide repeats 4 3437 2.968612864 0.00000601 19.75380759 2.995063164 proteolytic system__ 41171_at proteolytic activator subunit 2 5721 2.632747876 2.94E-08 5.101785113 3.339110072 1184 one at Protease activator subunit 2, P 5721 3.562723482 1.92E-12 4.791072135 2.802359636 3 84-at Protease subunit, β-type 10 5699 3.877228796 4.1E-14 5.603185012 3.630961741 38287_at Protease subunit, beta type 9 5698 4.659894959 4.78E-08 7.535678146 2.324895346 98677.doc -46- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 36600_at 蛋白酵體活化劑次單元 1 5720 2.628955624 7.22E-11 3.416274304 1.918170839 41184_s_at 蛋白酵體次單元，β-型 8 2.245374672 2.58E-08 3.576681689 1.30914074 重金屬結合 31622—f一 at 金屬硫肽1F(有功能的） 2.113411119 3.82E-13 1.9075731 2.31 466058 36564_at 金屬硫肽1Ε(有功能 的)?假基因 127544 2.12687658 2.86E-09 1.738158583 3.383316024 39120 at 金屬硫肽1L 4500 2.155505079 J.00010668 1.438072627 1.49279098 39081_at 金屬硫肽2Α 4502 3.88346697 9.5E-14 1.07990076 4.037912602 TNF配體和受體超級家族 3 7611一at TNF受體超級家族， 成員llb(姓骨抑制蛋白 (osteoprotegerin)) 4982 22.5815417 1.85E-11 3.732948102 23.80716306 32319一 at TNF(配體)超級家族成 員4 7292 -2.146064062 1.83E-07 -2.349718558 -3.490304298 31540一 at TNF-受體超級家族成 員9 3604 14.14497071 1.95E-09 31.32294502 8.13544291 34916_s_at TNF受體超級家族成 員4 7293 7.281386913 〇.〇〇〇〇〇〇36 17.13316176 14.8856408 組織相容性 40370一 f_at HLA-G組織相容性抗 原，第I、G類 3135 2.224416431 1.84E-09 2.315139184 1.850745369 37383 f at HLA-B 3107 2.813651868 1.31E-11 3.293656671 1.69656681 41237 at HLA-A 3105 2.592434929 1.07E-09 2.056585976 1.66805547 37421 f at HLA-F 3134 2.42786464 4.91 E-10 3.447090363 2.384322116 32321 at HLA-E 3133 2.208821209 1.1E-08 1.743423717 1.899995194 35017_f_at HLA-J(假基因） — 2.662234099 5.97E-10 3.747711512 2.904008691 其他 35320_at NRAMP2(二價金屬離 子運載） 4891 3.804011587 1.44E-12 3.429131292 3.883439443 40215一at UDP-葡萄糖神經醯胺 葡萄糖基轉移酶 7357 4.897679713 0 3.893723735 4.931113889 31697_s_at 鐵蛋白，重多肽1 — 2.105668901 0 1.337516978 1.511895019 33943_at 1 鐵蛋白，重多肽1 2495 3.122808312 2.78E-15 2.663086781 2.529725749 38970_s_at Nef-相關因子1 10318 7.45565406 0 10.89386893 7.958276569 38971丄at Nef-相關因子1 10318 9.653298205 5.55E-16 14.75346332 3.797994507 32610_at LIM功能部位蛋白質 (RIL，腫瘤抑制者） 8572 3.406069789 1.89E-14 4.377680625 3.218415014 3333 l_at BENE蛋白質(raft-調解 在ECs中的交易） 7851 -7.359188939 5.55E-16 -46.5789075 -18.37518426 39119_s_at 天然殺手細胞轉錄本4 9235 10.49660235 0 4.836079548 3.470433531 36065_at LIM功能部位結合2 9079 -7.075099306 6.45E-12 -11.70672404 -11.6004516 38332一 at 嘌呤能的受體P2X，配 體-開門的離子通道，4 5025 3.527832595 1.79E-12 6.839982825 3.28582656 41446—f一 at RNA解螺旋酶-相關的 蛋白質 — 2.049868207 9.01E-09 2.57850892 3.69227503 38631一at TNF-α-誘導之蛋白質2 7127 15.5435756 5.02E-13 25.32299307 20.2440913 4023 6一 at 陽離子胺基酸運載者2 6542 4.903862742 3.67E-14 3.66361 9476 5.136877139 98677.doc -47- 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 36600_at protein activator subunit 1 5720 2.628955624 7.22E-11 3.416274304 1.918170839 41184_s_at Protease subunit, β-type 8 2.245374672 2.58E-08 3.576681689 1.30914074 Heavy metal binding 31622-f-at metal thiopeptide 1F (functional) 2.113411119 3.82E-13 1.9075731 2.31 466058 36564_at metal thiopeptide 1E (functional ) Pseudogene 127544 2.12687658 2.86E-09 1.738158583 3.383316024 39120 at Metallothionein 1L 4500 2.155505079 J.00010668 1.438072627 1.49279098 39081_at Metallothionein 2A 4502 3.88346697 9.5E-14 1.07990076 4.037912602 TNF ligand and receptor superfamily 3 7611-at TNF receptor superfamily member llb (osteoprotegerin) 4982 22.5815417 1.85E-11 3.732948102 23.80716306 32319-at TNF (ligand) superfamily member 4 7292 -2.146064062 1.83E-07 -2.349718558 -3.490304298 31540- at TNF-receptor superfamily member 9 3604 14.14497071 1.95E-0 9 31.32294502 8.13544291 34916_s_at TNF receptor superfamily members 4 7293 7.281386913 〇〇〇〇〇〇〇〇36 17.13316176 14.8856408 histocompatibility 40370-f_at HLA-G histocompatibility antigen, Class I, G 3135 2.224416431 1.84E- 09 2.315139184 1.850745369 37383 f at HLA-B 3107 2.813651868 1.31E-11 3.293656671 1.69656681 41237 at HLA-A 3105 2.592434929 1.07E-09 2.056585976 1.66805547 37421 f at HLA-F 3134 2.42786464 4.91 E-10 3.447090363 2.384322116 32321 at HLA-E 3133 2.208821209 1.1E-08 1.743423717 1.899995194 35017_f_at HLA-J (pseudogene) — 2.662234099 5.97E-10 3.747711512 2.904008691 Other 35320_at NRAMP2 (divalent metal ion transport) 4891 3.804011587 1.44E-12 3.429131292 3.883439443 40215 one at UDP-glucosylceramide Glucosyltransferase 7357 4.897679713 0 3.893723735 4.931113889 31697_s_at ferritin, heavy peptide 1 — 2.105668901 0 1.337516978 1.511895019 33943_at 1 ferritin, heavy peptide 1 2495 3.122808312 2.78E-15 2.663086781 2.529725749 38970_s_at Nef-related factor 1 10318 7.45565406 0 10.89386893 7.958276569 38971 丄 at Nef-related factor 1 10318 9.653298205 5.55E-16 14.75346332 3.797994507 32610_at LIM functional site protein (RIL, tumor suppressor) 8572 3.406069789 1.89E-14 4.377680625 3.2at15014 3333 l BENE protein (raft-mediated transactions in ECs) 7851 -7.359188939 5.55E-16 -46.5789075 -18.37518426 39119_s_at Natural killer cell transcript 4 9235 10.49660235 0 4.836079548 3.470433531 36065_at LIM functional site binding 2 9079 -7.075099306 6.45E-12 -11.70672404 -11.6004516 38332-at purinergic receptor P2X, ligand-opening ion channel, 4 5025 3.527832595 1.79E-12 6.839982825 3.28582656 41446-f-at RNA helicase-related protein — 2.049868207 9.01E-09 2.57850892 3.69227503 38631-at TNF-α-induced protein 2 7127 15.5435756 5.02E-13 25.32299307 20.2440913 4023 6-at cationic amino acid carrier 2 6542 4.903862742 3.67E-14 3.66361 9476 5.136877139 98677.doc -47- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 41635_at Wilms·腫瘤1-關聯 蛋白質 9589 5.790617037 3.86E-13 5.777745597 7.816513232 36550一 at RAB5交互作用蛋白質 54453 4.287401682 1.33E-15 2.893396126 4.240726454 33791_at 在琳巴細胞性白jk病中 删除的，1 10301 -2.154987417 4.84E-07 -2.474972561 -3.124750447 39253_s_at 類ras蛋白質 5898 2.351506735 7.94E-11 2.022311156 3.104448716 39966一at 硫酸軟骨素蛋白多糖 5(神經多糖C) 10675 2.079781386 0.00034796 1.723347734 2.787442584 3526 l_at 神經膠質成熟因子，r 9535 4.535654994 3.76E-12 3.14631 4731 1.355411967 40051一at 類TRAM蛋白質(分泌 性蛋白質的移位） 9697 -2.023145895 1.16E-09 -2.064329419 -2.568060873 41191 一 at 帕拉定(palladin)(預測 的免疫球蛋白） 23022 2.402476155 3.82E-11 -1.092945296 2.895126951 38169_s_at 陽離子胺基酸運載者· 2A 6542 12.6862715 0 18.10015779 9.03591152 36175_s_at HIV第I型促進子-結 合蛋白質2 3097 4.702789112 4.64E-12 5.779921347 6.668812125 3373 l_at 溶質載劑家族7(陽離 子胺基酸運載者），成 員7 9056 6.830303999 5.23E-12 2.785124946 3.448986334 38617一at LIM功能1部位激酶2 3985 2.398434304 2.8E-11 3.05797248 3.089108758 4876_at 烏嘌呤核苷酸結合蛋白 質Ral，Ras致癌基因 相關 2.740128058 4.06E-11 3.184919976 4.783089817 33371—s一at RAB31，RAS致癌基因 家族成員 39959一at 二泛素 10537 154.5481774 2.13E-13 83.39051649 60.80792672 3 8268一 at 溶質載劑家族1，成員 1 6505 -3.494052945 2.36E-08 -2.323709091 -1 .880436681 34678一at 肌佛林(myoferlin)(第 π 型膜蛋白） 26509 -2.461785987 8.1E-11 -2.34118743 -4.428257826 37423_at 鈉/鉀/氣運載者 6558 5.863341383 8.58E-09 10.30897586 3.262676301 41048一at PMA-誘導之蛋白質1 5366 4.124831328 5.88E-11 5.374932281 2.751035089 1877_g_at ‘嘌呤核苷酸-結合蛋 白質Ral，Ras-致癌基 因相關的 2.263857729 3.19E-10 1.36624261 2.955732027 37749一at 中胚層專一之轉錄本 (老鼠)同系物 4232 -8.563686441 3.39E-12 -3.738761532 -1.890221954 3671 l_at MAFF(與催產素受體基 因結合） 23764 2.330148548 2.1E-10 3.660794234 3.509266911 35367一 at 外源凝集素，半乳糖 苦-結合，可溶的， 3(半乳糖凝集素 (galectin)3) 3958 2.847428796 2.49E-09 2.186535805 1.966123786 37393 at 毛同系物(果蠅） 3280 -2.104729557 0.0000105 -3.227167705 -2.968404609 41362一at 巨噬細胞脂質運載者 (ATP-結合） 9619 3.698756129 1.87E-08 3.126761474 2.360268513 40434 at 類普多卡辛 (podocalyxin)蛋白質 5420 2.479801376 2.27E-10 2.872125804 4.127017341 41554一at 染色體8開放編閱架構1 734 4.401795539 2E-10 6.312497146 6.214246908 38430一at 脂肪酸結合蛋白質4， 脂肪細胞 2167 11.71004306 1 .76E-08 -2.470683976 2.325955927 40427_at COX17(細胞色素c氧 化酶組裝） 10063 2.3179959 6.44E-09 3.564946719 2.403583185 41168_at 塔普辛(Tapasin)(抗原 加工） 6892 2.919975741 1.33E-09 4.008077657 3.002345356 38268_at 溶質載劑家族1，成員 6505 -3.494052945 2.36E-08 -2.323709091 -1.880436681 98677.doc -48- 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 41635_at WilmsTumor 1-associated protein 9589 5.790617037 3.86E-13 5.777745597 7.816513232 36550 at RAB5 interaction protein 54453 4.287401682 1.33E-15 2.893396126 4.240726454 33791_at deleted in Limba cell white jk disease, 1 10301 -2.154987417 4.84E-07 -2.474972561 -3.124750447 39253_s_at ras-like protein 5898 2.351506735 7.94E-11 2.022311156 3.104448716 39966-at chondroitin sulfate proteoglycan 5 (neuropolysaccharide C) 10675 2.079781386 0.00034796 1.723347734 2.787442584 3526 l_at glial maturation factor, r 9535 4.535654994 3.76E-12 3.14631 4731 1.355411967 40051-at TRAM-like protein (translocation of secreted proteins) 9697 -2.023145895 1.16E-09 -2.064329419 -2.568060873 41191 one at palladin (predicted immunoglobulin) 23022 2.402476155 3.82E-11 -1.092945296 2.895126951 38169_s_at cationic amino acid carrier 2A 6542 12.6862715 0 18.10015779 9.03591152 36175_s_at HIV type I promoter- Synthetic protein 2 3097 4.702789112 4.64E-12 5.779921347 6.668812125 3373 l_at Solute carrier family 7 (cationic amino acid carrier), member 7 9056 6.830303999 5.23E-12 2.785124946 3.448986334 38617-at LIM function 1 site kinase 2 3985 2.398434304 2.8E -11 3.05797248 3.089108758 4876_at uridine nucleotide binding protein Ral, Ras oncogene related 2.740128058 4.06E-11 3.184919976 4.783089817 33371-s-at RAB31, RAS oncogene family member 39959-at diubiquitin 10537 154.5481774 2.13E-13 83.39051649 60.80792672 3 8268-at solute carrier family 1, member 1 6505 -3.494052945 2.36E-08 -2.323709091 -1.880436681 34678-at myoferlin (type π membrane protein) 26509 -2.461785987 8.1E-11- 2.34118743 -4.428257826 37423_at sodium / potassium / gas carrier 6558 5.863341383 8.58E-09 10.30897586 3.262676301 41048-at PMA-induced protein 1 5366 4.124831328 5.88E-11 5.374932281 2.751035089 1877_g_at 'purine nucleotide-binding protein Ral, Ras-carcinogenic Gene related 2.263857729 3.19E-10 1. 36624261 2.955732027 37749-at Mesoderm-specific transcript (mouse) homolog 4232 -8.563686441 3.39E-12 -3.738761532 -1.890221954 3671 l_at MAFF (bound to oxytocin receptor gene) 23764 2.330148548 2.1E-10 3.660794234 3.509266911 35367-at Exogenous lectin, galectin-binding, soluble, 3 (galectin 3) 3958 2.847428796 2.49E-09 2.186535805 1.966123786 37393 at hair homologue (drosophila) 3280 -2.104729557 0.0000105 -3.227167705- 2.968404609 41362-at macrophage lipid carrier (ATP-bound) 9619 3.698756129 1.87E-08 3.126761474 2.360268513 40434 at podocalyxin-like protein 5420 2.479801376 2.27E-10 2.872125804 4.127017341 41554-at chromosome 8 open editing Architecture 1 734 4.401795539 2E-10 6.312497146 6.214246908 38430-at fatty acid binding protein 4, fat cells 2167 11.71004306 1 .76E-08 -2.470683976 2.325955927 40427_at COX17 (cytochrome c oxidase assembly) 10063 2.3179959 6.44E-09 3.564946719 2.403583185 41168_at Tap Tapasin (anti Processing) 6892 2.919975741 1.33E-09 4.008077657 3.002345356 38268_at solute carrier family 1, member 6505 -3.494052945 2.36E-08 -2.323709091 -1.880436681 98677.doc -48- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 1 33900一at 類卵泡抑素 (follistatin)3 (分泌性糖 蛋白） 10272 2.357044965 5.76E-08 2.168463959 1.891151792 32606一 at 腦富含的，膜附貼的信 號蛋白質1 10409 2.154773549 1.85E-07 1.676450671 2.705410717 37168一at 類似溶酶體相關的膜糖 蛋白 27074 2.18129371 0.00000117 5.66836506 3.858733053 1798一 at LIV-1蛋白質，*** 調節 25800 3.806942042 2.54E-07 5.605645413 2.523928805 40153_at ATP-結合卡匣，B2 6890 2.658243189 9.77E-10 6.565992214 2.011052241 39327_at 黑色素瘤相關之基因 7837 3.281662101 3.74E-13 .840301616 2.456998383 3 8787一 at 前骨髓細胞性白血病 5371 3.246279259 5.42E-09 5.014441081 1.86657737 33235_at 神經元航海家3 89795 2.126455294 8.42E-07 7.147716124 3.178133882 4039 l_at 溶質載劑家族22(有機 陽離子運載者），成員 4 6583 3.503572137 1.28E-08 5.751930923 2.915071673 39805_at ATP·結合卡匣，B6(粒 線體功能） 10058 -3.134810592 0.000062 -3.950118144 -7.557051796 38062_at Rapl之烏嘌呤核苷酸 交換因子；M-Ras-調節 的GEF 9771 2.385667595 0.00000123 3.284445082 2.129584571 36700_at 果蠅類Kelch蛋白質 56062 -2.210141615 0.00000889 -2.068838894 -3.814327142 543_g_at 細胞視黃酸結合蛋白質1 1381 2.37806162 0.00058519 12.12054759 3.960310682 40171一at 在進行性T-細胞淋巴 瘤2中經常重排的 23401 -2.042289921 0.00045387 -1.102930154 -3.45484887 38152_at 異質性(heterozygosity) 喪失，11(腫瘤抑制者） 4013 2.090463365 5.18E-07 1.10772429 1.474509395 41419 一 at CED·6蛋白質(?涉及細 胞凋零之細胞的吞噬作 用） 51454 2.160266818 0.0000141 2.790711625 2.280229173 40177一 at BRCA2 ~ •麵· 3.632767036 0.0000751 4.837141134 2.256454194 36156一at 水孔(aquaporin) 1 (形成 通道之嵌入蛋白質， 28kDa) 358 -7.543457532 7.36E-08 -24.72084587 -2.81472244 1451_s_at 成骨細胞專一因子 2(類成束蛋白 (fasciclin) I) 10631 -2.716285201 0.00096058 -3.058214965 -6.172371916 32052_at 血紅素，/3 3043 -2.82310622 0.00061531 -1.063359691 -1.063732475 38267一 at 溶質載劑家族1，成員1 6505 -2.372362221 0.0001239 -1.854384932 -4.202930496 34232_at 天然殺手-腫瘤認知序 列 4820 2.060240283 0.00081253 3.524334866 2.678630512 33533一at DnaJ(Hsp40)同系物， 亞家族B，成員4 11080 -3.248997846 1.27E-09 -3.405109343 -4.88373502 31803_at liB7蛋白質 ' 23308 8.62168092 6.66E-16 7.351063706 7.831573616 39517_at HTGN29蛋白質 一 56951 2.513008231 8.57E-12 3.043956898 3.301473663 3 2215丄at 含有Rho-相關之ΒΤΒ — 功能部位3 22836 4.025081573 2.65E-11 1.546933689 3.717203105 31974_at 封閉蛋白(claudin) 14 23562 5.268948019 7.62E-10 16.58450042 14.62230502 3 8234—at ***3的類轉導蛋白促 進子(E(spl)同系物，果 蠅） 7090 3.190483556 1.01E-08 5.862031912 2.662349924 717—at US3955蛋白質 28951 -5.936942813 1.1E-08 -3.058213083 -3.442126415 34759_at 人類 hbc647 mRNA 序 列 — -2.062062602 2.12E-07 -1.090273524 -1.859178255 40314_at 塞諾托林 (synaptogyrin)3 9143 2.59238833 5.12E-07 3.40394603 2.628868732 98677.doc -49- 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 1 33900-at follistatin 3 (secreted glycoprotein) 10272 2.357044965 5.76E-08 2.168463959 1.891151792 32606-at brain-rich, membrane-attached signal protein 1 10409 2.154773549 1.85E-07 1.676450671 2.705410717 37168-at similar to lysosomal-associated membrane glycoprotein 27074 2.18129371 0.00000117 5.66836506 3.858733053 1798- at LIV-1 protein, estrogen regulation 25800 3.806942042 2.54E-07 5.605645413 2.523928805 40153_at ATP-binding cassette, B2 6890 2.658243189 9.77E-10 6.565992214 2.011052241 39327_at melanoma-related gene 7837 3.281662101 3.74E-13 .840301616 2.456998383 3 8787 One at pre-bone marrow cell leukemia 5371 3.246279259 5.42E-09 5.014441081 1.86657737 33235_at neuron navigator 3 89795 2.126455294 8.42E-07 7.147716124 3.178133882 4039 l_at solute carrier family 22 (organic cation carrier), member 4 6583 3.503572137 1.28E- 08 5.751930923 2.915071673 39805_at ATP Cartridge, B6 (mitochondrial function) 10058 -3.134810592 0.000062 -3.950118144 -7.557051796 38062_at Rapl uridine nucleotide exchange factor; M-Ras-regulated GEF 9771 2.385667595 0.00000123 3.284445082 2.129584571 36700_at Drosophila Kelch protein 56061 -2.210141615 0.00000889 -2.068838894 -3.814327142 543_g_at Cell retinoic acid-binding protein 1 1381 2.37806162 0.00058519 12.12054759 3.960310682 40171-at 23401 -2.042289921 0.00045387 -1.102930154 -3.45484887 38152_at Heterogeneity that is frequently rearranged in progressive T-cell lymphoma 2 11 (tumor suppressor) 4013 2.090463365 5.18E-07 1.10772429 1.474509395 41419 one at CED · 6 protein (? Involved in phagocytosis of cells withering) 51454 2.160266818 0.0000141 2.790711625 2.280229173 40177 one at BRCA2 ~ • noodles 3.632767036 0.0000751 4.837141134 2.256454194 36156-at aquaporin 1 (channel-forming embedded protein, 28kDa) 358 -7.543457532 7.36E-08 -24.72084587 -2.81472244 1451_s_at osteoblast-specific factor 2 (class Fasciclin I) 10631 -2.716285201 0.00096058 -3.058214965 -6.172371916 32052_at heme, / 3 3043 -2.82310622 0.00061531 -1.063359691 -1.063732475 38267-at solute carrier family 1, member 1 6505 -2.372362221 0.0001239 -1.854384932 -4.202930496 34at Killer-tumor cognitive sequence 4820 2.060240283 0.00081253 3.524334866 2.678630512 33533-at DnaJ (Hsp40) homologue, subfamily B, member 4 11080 -3.248997846 1.27E-09 -3.405109343 -4.88373502 31803_at liB7 protein '23308 8.62168092 6.66E-16 7.351063706 7.831573616 39517 HTGN29 protein 56951 2.513008231 8.57E-12 3.043956898 3.301473663 3 2215 丄 at Contains Rho-related BTTB-functional site 3 22836 4.025081573 2.65E-11 1.546933689 3.717203105 31974_at cladin 14 23562 5.268948019 7.62E-10 16.58450042 14.62230502 3 8234 —At split 3 like transduction protein promoter (E (spl) homologue, Drosophila) 7090 3.190483556 1.01E-08 5.862031912 2.662349924 717—at US3955 protein 28951 -5.936942813 1.1E-08 -3.0 58213083 -3.442126415 34759_at human hbc647 mRNA sequence — -2.062062602 2.12E-07 -1.090273524 -1.859178255 40314_at synaptogyrin 3 9143 2.59238833 5.12E-07 3.40394603 2.628868732 98677.doc -49- 200533758

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 1562_g_at 雙重專一性磷酸酶8 1850 3.469723923 6.19E-07 2.160285876 1.814944895 34075一 at 環指蛋白質3 10336 2.474945089 6.84E-07 1.570008537 1.324684407 158 一 at DnaJ(Hsp40)同系物， 亞家族B，成員4 11080 -3.069096975 9.69E-07 -5.612414258 -4.225643684 35628_at 穿透膜7超級家族成員2 7108 -2.262624361 0.00000127 -7.138287918 -7.896982242 39532一at Ras和Rab互動者1 9610 -2.446039394 0.00000369 -2.423287325 -4.576385229 32464一 at 防禦素(defensin)，召4 1673 — 5.73206473 0.00000396 9.471669184 5.787182569 40398_s_at 間葉同源異形盒2(生 長妨礙-專一之同源異 形盒） 4223 -2.929695911 0.00000406 -3.319848792 -1.032947415 36691一 at 半胱胺酸-共軛物-召裂 合酶；細胞質的 883 -2.592484271 0.00000419 -4.781646333 -4.268473905 32285_g_at T-盒子1 6899 3.404797802 0.00000657 .4.474254059 •1.100885777 3528 l_at 人類昆布胺酸r2鏈 基因 — 7.305157538 0.0000141 1.253227767 3.632687454 36852_at 假設的***癌腫瘤抑 制者 7991 2.0126302 0.000015 1.834058874 1.163775279 35350_at B細胞RAG關聯 蛋白質 51363 -2.378507434 0.0000163 -2.826314014 -2.971591523 3 8223一 at 含有企管Rab· GAP/TBC 11138 •2.237040168 0.0000198 -2.17332853 -6.419950691 1778一 g—at Ras和Rab互動者1 9610 -2.039906548 0.0000265 •2.354421127 -2.277558206 34748_at Rapl之烏嘌呤核苷酸 交換因子 25780 4.876306368 0.0000375 1.998297818 1.431030207 3 8177—at 受體(降血鈣素)活性修 改蛋白質2 10266 -2.669452927 0.0000544 -1.504408342 -1.725233883 36767—at 細胞色素P450，亞家 族1(芳香族化合物-可 誘導的），多肽1 1543 -3.25254729 0.0000617 -2.335422922 -2.35009816 36103一 at LD78a前驅物 — 4.751320817 0.0000661 7.445011283 16.10643497 3 8916一 at 染色體X開放編閱架 構6 10046 -2.03566901 0.0000766 -2.600257104 -1.605985898 37695_at 老鼠泛素共軛酵素7交 互作用蛋白質4的可能 異物種同源基因 9781 -2.301917036 0.00012133 -1.323110698 1.160790171 37452—at 尿調節素 (uromodulin)(尿黏蛋白 (uromucoid) Tamm-Horsfall糖蛋白） 7369 -2.459571854 0.00013772 1.432388832 -2.496391159 38298_at 鉀大傳導妈-激活通道， 亞家族Μ，β成員1 3779 2.267192754 0.00014094 1.805996602 2.016570577 34265一at 分泌性顆粒，神經内分 泌蛋白質U7B2蛋白 質） 6447 2.136706898 0.00020271 2.37154058 6.591 60987 3 7420丄 at 主要組織相容性複合 物，第I類，F … 6.41 8888272 0.00020626 12.57659136 4.328385052 1024_at 細胞色素Ρ450，亞家 族1(芳香族化合物-可 誘導的），多肽1 1543 -2.278885393 0.00021089 -4.433899159 -5.141649045 40604—at 雙重-專一性酪胺酸· (Υ)-磷酸化作用調節之 激酶2 8445 -4.160877249 0.00021373 -1.00374691 -1.088223843 37830_at 穿透膜4超級家族成員 特拉斯潘 (tetraspan)NET-5 10867 2.717292959 0.0002566 1.697194729 2.682188088 39579_at 封閉蛋白10 9071 -2.657823461 0.00029297 -1.222678519 -2.151570787 39826_f_at HIF-1 反應性 RTP801 54541 2.730193575 0.00029395 2.196725544 -1.095320201 98677.doc -50- 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 1562_g_at dual specificity phosphatase 8 1850 3.469723923 6.19E-07 2.160285876 1.814944895 34075-at Ring finger protein 3 10336 2.474945089 6.84E-07 1.570008537 1.324684407 158 one at DnaJ (Hsp40) homolog, subfamily B, member 4 11080 -3.069096975 9.69E-07 -5.612414258 -4.225643684 35628_at penetration membrane 7 super family member 2 7108- 2.262624361 0.00000127 -7.138287918 -7.896982242 39532-at Ras and Rab interactors 1 9610 -2.446039394 0.00000369 -2.423287325 -4.576385229 32464-at defensin, call 4 1673 — 5.73206473 0.00000396 9.471669184 5.787182569 40398_s_at Specific homeobox) 4223 -2.929695911 0.00000406 -3.319848792 -1.032947415 36691 one at cysteine-conjugate-recall lyase; cytoplasmic 883 -2.592484271 0.00000419 -4.781646333 -4.268473905 32285_g_at T-box 1 6899 3.404797802 0.00000657 .4.474254059 • 1.100885777 3528 l_at human cuminic acid r2 Gene — 7.305157538 0.0000141 1.253227767 3.632687454 36852_at Hypothetical prostate cancer tumor suppressor 7991 2.0126302 0.000015 1.834058874 1.163775279 35350_at B-cell RAG-associated protein 51363 -2.378507434 0.0000163 -2.826314014 -2.971591523 3 8223-at contains Enterprise Management Rab · GAP / TBC 1 13198198 2.2.2370 -6.419950691 1778-g-at Ras and Rab interactors 1 9610 -2.039906548 0.0000265 • 2.354421127 -2.277558206 34748_at Rapl uridine nucleotide exchange factor 25780 4.876306368 0.0000375 1.998297818 1.431030207 3 8177-at receptor (calcitonin) activity modification Protein 2 10266 -2.669452927 0.0000544 -1.504408342 -1.725233883 36767-at cytochrome P450, subfamily 1 (aromatic compound-inducible), peptide 1 1543 -3.25254729 0.0000617 -2.335422922 -2.35009816 36103 -at LD78a precursor-4.751320817 0.0000661 7.445011283 16.10643497 3 8916-at chromosome X open editing architecture 6 10046 -2.03566901 0.0000766 -2.600257104 -1.605985898 37695_at mouse ubiquitin conjugate 7 Possible heterologous homologous genes for interaction protein 4 9781 -2.301917036 0.00012133 -1.323110698 1.160790171 37452-at uromodulin (uromucoid Tamm-Horsfall glycoprotein) 7369 -2.459571854 0.00013772 1.432388832 -2.496391159 38298_at potassium Large conduction mom-activated channel, subfamily M, beta member 1 3779 2.267192754 0.00014094 1.805996602 2.016570577 34265 one at secretory particles, neuroendocrine protein U7B2 protein) 6447 2.136706898 0.00020271 2.37154058 6.591 60987 3 7420 丄 at major histocompatibility complex, Class I, F ... 6.41 8888272 0.00020626 12.57659136 4.328385052 1024_at Cytochrome P450, subfamily 1 (aromatic compound-inducible), peptide 1 1543 -2.278885393 0.00021089 -4.433899159 -5.141649045 40604-at double-specific tyrosine · (Υ)-Kinase 2 regulated by phosphorylation 2 8445 -4.160877249 0.00021373 -1.00374691 -1.088223843 37830_at Transmembrane 4 super family member tetraspan NET-5 10867 2.717292959 0.0002566 1.697194729 2.6821880 88 39579_at Blocking protein 10 9071 -2.657823461 0.00029297 -1.222678519 -2.151570787 39826_f_at HIF-1 reactivity RTP801 54541 2.730193575 0.00029395 2.196725544 -1.095320201 98677.doc -50- 200533758

探針組 說明 ___ __ 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 34432_at I力能邵位蛋白質 9047 3.310710864 0.00030924 7.989570792 23.07377029 3 7241一at 腫瘤伴隨^ (paraneoplastic)抗原 MA2 10687 -2.442605109 0.00032556 -1.856943883 -2.613966323 40606_at bLL-相關之奶八聚合 酶π，延長因子 22936 2.424019485 0.00037794 3.31621885 2.346164265 1561_at 雙重專一性磷酸酶8 1850 3.434679205 0.00038896 1.001924133 1.383633356 39300_at 類鈣調素(calmodulin)3 810 -3.091045664 0.00042474 1.486878275 -1.021019291 36965_at 錯蛋白(ankyrin)3，蘭 氏結(node of Ranvier)(錨蛋白 G) 288 -2.723182368 0.00044183 -1.044035474 -2.023634007 37514_s_at 甘露聚糖-結合之外源 凝集素絲胺酸蛋白酶2 10747 2.200703073 0.00058878 2.16677628 1.730660832 40626 at 美特辛(metaxin)l 4580 -2.054132333 0.00078486 -1.062883007 -1.186917557 32216一r一 at Rh〇-相關之BTB功能 部位含有3 22836 2.64711066 0.00085998 1.556636149 3.676801387 39680一at 斯塔舍林(statherin) 6779 3.677272808 0.00091313 3.76121132 1.183111878 32944一 at 迂迴的，軸索引導受 體，同系物1(果蠅） 6091 2.375016818 0.00093376 1.799248044 1.615217552 -51 - 98677.doc 200533758 表lb由炎症介體調節，具有未知功能的基因和ESTsProbe set description ___ __ Site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 34432_at I force energy protein 9047 3.310710864 0.00030924 7.989570792 23.07377029 3 7241 a at tumor-associated ^ (paraneoplastic) antigen MA2 10687 -2.442605109 0.00032556 -1.856943883 -2.613966323 40606_at bLL-related milk octapolymerase π, elongation factor 22936 2.424019485 0.00037794 3.31621885 2.346164265 1561_at dual specificity phosphatase 8 1850 3.434679205 0.00038896 1.001924133 1.383633 Calmodulin 3 810 -3.091045664 0.00042474 1.486878275 -1.021019291 36965_at ankyrin 3, node of Ranvier (ankyrin G) 288 -2.723182368 0.00044183 -1.044035474 -2.023634007 37514_s_at Mannan-except binding Source lectin serine protease 2 10747 2.200703073 0.00058878 2.16677628 1.730660832 40626 at metaxin l 4580 -2.054132333 0.00078486 -1.062883007 -1.186917557 32216-r-at Rh〇-related BTB functional sites contain 3 22836 2.64711066 0.00085998 1.556636149 3 .676801387 39680-at statherin 6779 3.677272808 0.00091313 3.76121132 1.183111878 32944-at roundabout, axis indexing receptor, homolog 1 (drosophila) 6091 2.375016818 0.00093376 1.799248044 1.615217552 -51-98677.doc 200533758 Table lb Genes and ESTs with unknown functions regulated by inflammatory mediators

探針組 說明 位點連接 HUVEC FC(n=7) 貝氏P值 HCAEC FC(n=l) MVEC FC(n=l) 34800_at AL039458: DKFZp434NO910一 si 人類cDNA，3末逞 26018 3.40078204 2.85E-13 2.765010993 6.664710547 38393_at KIAA0247基因產物 9766 2.29784077 1.67E-09 6.02008351 4.413369148 34678_at AL096713:人類 mRNA ； cDNA DKFZp564E1616 26509 -2.461785987 8.1E-11 -2.34118743 -4.428257826 39602_at AL050090:人類 mRNA、； cDNA DKFZp586F1018 25924 -4.577280769 0.0000172 -4.30119521 -10.40709155 38717_at AL050159:人類 mRNA ； cDNA DKFZp586A0522 25840 -4.689298781 1.28E-08 -7.74893638 -11.28080814 40642_at cDNA DKFZp564H1916(得 自純種系 DKFZp564H1916) -2.496243538 1 .49E-09 -3.8269357 -4.459353442 36336 s at K1AA0963 22904 2.332740057 5.13E-09 8.689197154 4.182729484 38510一at AL049435:人類 mRNA ； cDNA DKFZp586B0220 5.396432597 9.74E-11 6.475495162 2.715475488 41690_at AL049471:人類 mRNA ； cDNA DKFZp586N012 3.796753878 2.31E-07 3.480379946 4.086635283 37786一at 人類純種系24707 mRNA序列 2.683364137 0.0001284 2.585161023 1.833430515 41837一 at 假設的蛋白質 DKFZp761F2014 56967 -2.367358274 0.0000417 -2.170427473 -2.218598517 3 5959一 at KIAA0844蛋白質 22891 3.512525058 0.0000819 1.000129624 1.57103734 36250_at 人類純種系24488 mRNA序列 — 2.099339801 0.0000777 2.646927476 -1.069488008 3 8749一 at 假設的蛋白質 MGC29643 116372 -6.715917049 0.0000192 -5.323536941 -5.128912423 31849一 at KIAA0564蛋白質 23078 2.224449383 8.58E-07 -1.476396381 -1.27776956 39827一 at 假設的蛋白質(HIF-1 反應性的） 54541 2.094989151 5.69E-09 -1.05607484 1.073522919 35763一at KIAA0540蛋白質 23218 -4.219436032 1 .45E-10 -2.077617899 -6.313755213 34176_at 得自純種系643的假 設蛋白質 57228 -2.112126935 1 .23E-08 -1.597169536 -1.875122258 41229—at 人類 mRNA ; cDNA DKFZp564H1916 -2.2358848 9.58E-09 -2.83431221 3.1640925 36497_at 假設的蛋白質 BC011859 113146 -3.616464046 2.82E-11 -4.334097766 -8.757335062 32110一at KIAA0523蛋白質 23302 -2.745882047 2.07E-08 -2.214350233 -2.866714311 33325—at 人類純種系 IMAGE:4151609， mRNA，mRNA 序列 2.176427217 6.55E-08 3.266179064 2.671921634 3 6014一at 假設的蛋白質 DKFZp564D0462 57211 -5.760412704 3.71E-12 -8.607279686 -9.578098002 4085 5_at KIAA1053蛋白質 23034 2.816692342 2.05E-11 2.161737313 2.608672841 37216一at KIAA0963蛋白質 22904 6.46210333 3.22E-13 8.253255749 4.410973232 40472_at PISC功能部位含有 假設的蛋白質 254531 -2.478023126 0.00000857 -1.900414388 -7.223997137 41735_at KIAA0870蛋白質 22898 2.356691777 0.0000579 3.836683893 1.946020466 32385_at 人類 mRNA ; cDNA DKFZp566F1224 — -3.217722448 0.00028948 -1.690512627 -1.478976553 41710_at 假設的蛋白質 54103 6.540656908 0.0002523 6.153505937 6.999868011 98677.doc -52- 200533758Probe set description site connection HUVEC FC (n = 7) Bayesian P value HCAEC FC (n = l) MVEC FC (n = l) 34800_at AL039458: DKFZp434NO910-si human cDNA, 3 terminal 26018 3.40078204 2.85E-13 2.765010993 6.664710547 38393_at KIAA0247 gene product 9766 2.29784077 1.67E-09 6.02008351 4.413369148 34678_at AL096713: human mRNA; cDNA DKFZp564E1616 26509 -2.461785987 8.1E-11 -2.34118743 -4.428257826 39602_at AL050090: human mRNA, -200. 38717_at AL050159: human mRNA; cDNA DKFZp586A0522 25840 -4.689298781 1.28E-08 -7.74893638 -11.28080814 40642_at cDNA DKFZp564H1916 (obtained from the pure line DKFZp564H1916) -2.496243538 1 .49E-09 -3.8269357 -4.4593 3962 at 3591 96AA 36336 09 8.689197154 4.182729484 38510-at AL049435: human mRNA; cDNA DKFZp586B0220 5.396432597 9.74E-11 6.475495162 2.715475488 41690_at AL049471: human mRNA; cDNA DKFZp586N012 3.796753878 2.31E-07 3.480379946 4.086635283 37786-at human pure Line 24707 mRNA sequence 2.683364137 0.0001284 2.585161023 1.833430515 41837-at Hypothetical protein DKFZp761F2014 56967 -2.367358274 0.0000417 -2.170427473 -2.218598517 3 5959-at KIAA0844 protein 22891 3.512525058 0.0000819 1.000129624 1.57103734 36250_at human pure line 2.649 629 498-008488 0.0000-00 -At hypothetical protein MGC29643 116372 -6.715917049 0.0000192 -5.323536941 -5.128912423 31849 -at KIAA0564 protein 23078 2.224449383 8.58E-07 -1.476396381 -1.27776956 39827 -at hypothetical protein (HIF-1 reactive) 54541 2.094989151 5.69E-09- 1.05607484 1.073522919 35763-at KIAA0540 protein 23218 -4.219436032 1 .45E-10 -2.077617899 -6.313755213 34176_at Hypothetical protein from pure line 643 57228 -2.112126935 1 .23E-08 -1.597169536 -1.875122258 41229-at human mRNA; cDNA DKFZp564H1916 2.2358848 9.58E-09 -2.83431221 3.1640925 36497_at Hypothetical protein BC011859 113146 -3.616464046 2.82E-11 -4.334097766 -8.757335062 32110-at KIAA0523 protein 23302 -2.745882047 2.07E-08 -2.214350233 -2.866714311 33325-at human pure germline IMAGE: 4151609, mRNA, mRNA sequence 2.176427217 6.55E-08 3.266179064 2.671921634 3 6014-at hypothetical protein DKFZp564D0462 57211 -5.760412704 3.71 E-12 -8.607279686 -9.578098002 4085 5_at KIAA1053 protein 23034 2.816692342 2.05E-11 2.161737313 2.608672841 37216-at KIAA0963 protein 22904 6.46210333 3.22E-13 8.253255749 4.410973232 40472_at The PISC functional site contains a hypothetical protein 254531 -2.478023126 0.00000857 -1.9997137AA 0137378AA41 Protein 22898 2.356691777 0.0000579 3.836683893 1.946020466 32385_at human mRNA; cDNA DKFZp566F1224--3.217722448 0.00028948 -1.690512627 -1.478976553 41710_at Hypothetical protein 54103 6.540656908 0.0002523 6.153505937 6.999868011 98677.doc -52- 200533758

LOC54103 35484_at 未知的 (IMAGE:5177668 的 蛋白質)[人類]mRNA 序列 -2.144224745 0.00082522 -3.214996363 -1.249999657 39582一at 人類 mRNA ; cDNA DKFZp586D1122 … 2.047922256 0.00075152 4.318196752 2.0788606 34857一at 假設的蛋白質(?陽離 子-運載的ATP酶） 79572 4.947142933 7.33E-15 6.560037706 9.528191509 39597_at KIAA0843蛋白質 22885 2.251002894 3.31E-09 1.463446202 1.540119179 3 8972一at 假設的蛋白質(?黏液 素蛋白質） 115207 -3.47649954 2.91E-13 -7.807767943 -11 .3252609 33924一at KIAA1091蛋白質 (功能未知） 23258 2.032421884 3.58E-08 2.704538654 2.417232497 40239_g_at 假設的蛋白質 MGC35048 124152 2.19014209 0.00000228 1.613513848 3.423127335 34303一 at 假設的蛋白質 FLJ90798 219654 -4.704828617 0.00000675 -2.511409176 -5.24800397 3 7030一at 在異位性皮炎中，在 T-細胞和嗜曙紅細胞 中表現， 23197 2.060834569 9.18E-07 1.188459581 1.046205726 32791一at MAC30(假設的蛋白 質） 27346 -2.011357014 6.47E-07 -2.174949259 -1.604404811 1529—at 假設的蛋白質 CG003 10129 -2.488539403 2.91E-08 -3.553893245 -4.186928468 37788_at 人類純種系23688 mRNA序列 -2.047017635 0.00028466 -3.046721831 -2.16341444 39837_s_at 人類PAC純種系 DJ0751 H13 得自 7q35-qter -3.168754335 3.43E-07 -6.848331513 -1.485922984 35861 cDNA，3末端/純種 系=IMAGE-362388 2.102166336 0.00032601 6.510939455 6.956139377 -53 - 98677.doc 200533758 表2a :確認表la之轉錄本的探針序列 >1736_at HG-U95AV2 agtaaaccccaagcaggcactgcccgcccacaggatgtgaaccgcagagaccaacagagg aatccaggcacctctaccacgccctcccagcccaattctgcgggtgtccaagacactgag atgggcccatgccgtagacatctggactcagtgctgcagcaactccagactgaggtctac cgaggggctc'aaacactctacgtgcccaattgtgaccatcgaggcttctaccggaagcgg cagtgcc >34021_at HG-U95Av2 caagaatcccaaactcaccaggatgctcacatttaagttttacatgcccaagaaggccac agaactgaaacatcttcagtgtctagannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnagggatctgaaacaacatteatgtgtgaatatgetgatgagac agcaaccattgtagaatttctgaacagatggatt a cnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc11 ctatttatttaaa tatttaaattttatatttattgttgaatgtatggtttgctacctattgtaacLOC54103 35484_at unknown (IMAGE: 5177668 protein) [human] mRNA sequence-2.144224745 0.00082522 -3.214996363 -1.249999657 39582-at human mRNA; cDNA DKFZp586D1122… 2.047922256 0.00075152 4.318196752 2.0788606 34857-at hypothetical protein (? Cation-carrying ATP ) 79572 4.947142933 7.33E-15 6.560037706 9.528191509 39597_at KIAA0843 protein 22885 2.251002894 3.31E-09 1.463446202 1.540119179 3 8972-at Hypothetical protein (? Mucin protein) 115207 -3.47649954 2.91E-13 -7.807767943 -11.3252609 33924-at KIAA1091 Protein (unknown function) 23258 2.032421884 3.58E-08 2.704538654 2.417232497 40239_g_at Hypothetical protein MGC35048 124152 2.19014209 0.00000228 1.613513848 3.423127335 34303-at Hypothetical protein FLJ90798 219654 -4.704828617 0.00000675 -2.511409176 -5.24800397 3 7030-at Expressed in T-cells and eosinophils, 23197 2.060834569 9.18E-07 1.188459581 1.046205726 32791-at MAC30 (hypothetical protein) 27346-2. 011357014 6.47E-07 -2.174949259 -1.604404811 1529-at hypothetical protein CG003 10129 -2.488539403 2.91E-08 -3.553893245 -4.186928468 37788_at human pure line 23688 mRNA sequence -2.047017635 0.00028466 -3.046721831 -2.16341444 39837_s_at human PAC pure line DJ0751 H13 Obtained from 7q35-qter -3.168754335 3.43E-07 -6.848331513 -1.485922984 35861 cDNA, 3-terminal / pure line = IMAGE-362388 2.102166336 0.00032601 6.510939455 6.956139377 -53-98677.doc 200533758 Table 2a: Confirmation of the transcript of Table la needle sequence > nnnnnnnnnnnnnnnnna 34021_at HG-U95Av2 caagaatcccaaactcaccaggatgctcacatttaagttttacatgcccaagaaggccac agaactgaaacatcttcagtgtctagannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn; 1736_at HG-U95AV2 agtaaaccccaagcaggcactgcccgcccacaggatgtgaaccgcagagaccaacagagg aatccaggcacctctaccacgccctcccagcccaattctgcgggtgtccaagacactgag atgggcccatgccgtagacatctggactcagtgctgcagcaactccagactgaggtctac cgaggggctc'aaacactctacgtgcccaattgtgaccatcgaggcttctaccggaagcgg cagtgcc & gt gggatctgaaacaacatteatgtgtgaatatgetgatgagac agcaaccattgtagaatttctgaacagatggatt a cnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc11 ctatttatttata tatttaaattttatattttattttgtac gatat

>350 61__at HG-U95Av2 ggagtcaagcccttataagtcaaaagcatctatgtgtcgtaaagcattcctcaaacattt tttcatgcaaatacacanttctrtccccaaatatcatgtagcacatcaatatgtagggaa acattcttatgcatcatttggtttgttttataaccaattcattaaatgtaattcataaaa tgtactatgaaaaaaattatacgctatgggatactggcaacagtgcacatatttcataac caaattagcagcaccggtcttaatttgatgtttttcaacttttattcattgagatgtttt gaagcaattaggatatgtgtgtttactgtactttttgttttgatccgtttgtataaa<ga tagcaatatcttggacacatttga >3 64 44_s__at HG-U95Av2 ttccatgctactagtgctgactgctgcatctcctacaccccacgaagcatcccgtgttca ctcctggagagttactttgaaacgaacagcgagtgctccaagccgggtgtcatcttcctc accaagaaggggcgacgtttctgtgccaaccccagtgataagcaagttcaggtttgcatg agaatgctgaagctggacacacggatcaagaccaggaagaattgaacttgtcaaggtgaa gggacacaagttgccagccaccaactttcttgcctcaactaccttcctgaattatttttt taagaagcatttattcttgtgttctggatttagagcaattcatc >36782_s_at HG-U95Av2 ttcttccaatatgacacctggaagcagtccacccagcgcctgcgcaggggcctgcctgcc ctcctgcgtgcccgccggggtcacgtgctcgccaaggagctcgaggcgttcagggaggcc aaacgtcaccgtcccctgattgctctacccacccaagaccccgcccacgggggcgccccc ccagagatggccagcaatcggaagtgagcaaaactgccgcaagtctgcagcccggcgcca ccatcctgcagcctcctcctgaccacggannnnnnnnnnnnnnnnnnnnncgaaaatctc tcggttccacgtccccctggggcttctcctgacccagtccccgtgcccGgcctccccgaa acaggctactctcctcggccccctccatcgggctgaggaagcacagcagcatcttcaaac atgtacaaaatcgattggctttaaaca >37319_at HG-U95Av2 cccaagaaggtctggcaaagtcaggctcagggagactctgccctgctgcagacctcggtg tggacacacgctgcatagagctctccttgaaaacagaggggtctcaagacattctgccta cc >4 31__at HG-U9 5AV2 actctaagtggcattcaaggagtacctctctctagaaccgtacgctgtacctgcatcagc attagtaatcaacctgttaatccaaggtctttagaaaaacttgaaattattcctgcaagc caattttgtccacgtgttgagatcattgctacaatgaaaaagaagggtgagaagagatgt ctgaatccagaatcgaaggccatcaagaatttactgaaagcagttagcaaggaaa 54- 98677.doc 200533758 >1006_at HG-U95AV2 ctgaggaacccctggtgcccacaaaatctgttccttcgggatctgagatgccagccaagt gtgatcctgctttgtccttcgatgccatcagcactctgaggggagaatatctgttcttta aagacagatatttttggcgaagatcccactggaaccctgaacctgaatttcatttgattt ctgcattttggccctctcttccatcatatttggatgctgcatatgaagttaacagcaggg acaccgtttttatttttaaaggaaatgagttctgggccatcagaggaaatgaggtacaag caggttatccaagaggcatccataccctgggttttcctccaaccataaggaaaattgatg cagctgtttctgacaaggaaaagaagaaaacatacttctttgcagcggacaaatactgga gatttgatgaaaatagccagtccatggagcaaggcttccctagactaatagctgatgact ttccaggagttgagcctaaggttgatgctgtattacaggcatttggatttttctacttct tcagtggatcatcacagtttgagtttgaccccaatgccaggatggtgacacacatattaa agagtaa >1024_at HG-U95Av2 aagctctgaagaactctctggaagcccctgggcccagtacctagctggctctgtgagggt gctgactggcttcagcaagttagaactagccaaaccaggaccctgtcca >1052_s_at HG-U95AV2 agaacgagaagctgcaccagcgcgtggagcagctcacgcgggacctggccggcctccggc≫ 350 61__at HG-U95Av2 ggagtcaagcccttataagtcaaaagcatctatgtgtcgtaaagcattcctcaaacattt tttcatgcaaatacacanttctrtccccaaatatcatgtagcacatcaatatgtagggaa acattcttatgcatcatttggtttgttttataaccaattcattaaatgtaattcataaaa tgtactatgaaaaaaattatacgctatgggatactggcaacagtgcacatatttcataac caaattagcagcaccggtcttaatttgatgtttttcaacttttattcattgagatgtttt gaagcaattaggatatgtgtgtttactgtactttttgttttgatccgtttgtataaa < ga tagcaatatcttggacacatttga > 3 64 44_s__at HG-U95Av2 ttccatgctactagtgctgactgctgcatctcctacaccccacgaagcatcccgtgttca ctcctggagagttactttgaaacgaacagcgagtgctccaagccgggtgtcatcttcctc accaagaaggggcgacgtttctgtgccaaccccagtgataagcaagttcaggtttgcatg agaatgctgaagctggacacacggatcaagaccaggaagaattgaacttgtcaaggtgaa gggacacaagttgccagccaccaactttcttgcctcaactaccttcctgaattatttttt taagaagcatttattcttgtgttctggatttagagcaattcatc > 36782_s_at HG-U95Av2 ttcttccaatatgacacctggaagcagtccacccagcgcctgcgcaggggcctgcctgcc ctcctgcgtgcccgccggggtcacgtgctcgccaaggagctcgaggcgttcagggaggcc aaacgtcaccgtcccctgattgctctacccacccaagaccccgcccacgggggcgc cccc ccagagatggccagcaatcggaagtgagcaaaactgccgcaagtctgcagcccggcgcca ccatcctgcagcctcctcctgaccacggannnnnnnnnnnnnnnnnnnnncgaaaatctc tcggttccacgtccccctggggcttctcctgacccagtccccgtgcccGgcctccccgaa acaggctactctcctcggccccctccatcgggctgaggaagcacagcagcatcttcaaac atgtacaaaatcgattggctttaaaca > 37319_at HG-U95Av2 cccaagaaggtctggcaaagtcaggctcagggagactctgccctgctgcagacctcggtg tggacacacgctgcatagagctctccttgaaaacagaggggtctcaagacattctgccta cc > 4 31__at HG-U9 5AV2 actctaagtggcattcaaggagtacctctctctagaaccgtacgctgtacctgcatcagc attagtaatcaacctgttaatccaaggtctttagaaaaacttgaaattattcctgcaagc caattttgtccacgtgttgagatcattgctacaatgaaaaagaagggtgagaagagatgt ctgaatccagaatcgaaggccatcaagaatttactgaaagcagttagcaaggaaa 54- 98677.doc 200533758 > 1006_at HG-U95AV2 ctgaggaacccctggtgcccacaaaatctgttccttcgggatctgagatgccagccaagt gtgatcctgctttgtccttcgatgccatcagcactctgaggggagaatatctgttcttta aagacagatatttttggcgaagatcccactggaaccctgaacctgaatttcatttgattt ctgcattttggccctctcttccatcatatttggatgctgcatatgaagttaacagcaggg acaccgtttttatttttaaagg aaatgagttctgggccatcagaggaaatgaggtacaag caggttatccaagaggcatccataccctgggttttcctccaaccataaggaaaattgatg cagctgtttctgacaaggaaaagaagaaaacatacttctttgcagcggacaaatactgga gatttgatgaaaatagccagtccatggagcaaggcttccctagactaatagctgatgact ttccaggagttgagcctaaggttgatgctgtattacaggcatttggatttttctacttct tcagtggatcatcacagtttgagtttgaccccaatgccaggatggtgacacacatattaa agagtaa > 1024_at HG-U95Av2 aagctctgaagaactctctggaagcccctgggcccagtacctagctggctctgtgagggt gctgactggcttcagcaagttagaactagccaaaccaggaccctgtcca > 1052_s_at HG-U95AV2 agaacgagaagctgcaccagcgcgtggagcagctcacgcgggacctggccggcctccggc

agttcttcaagcagctgcccagcccgcccttcctgccggcc^ccgggacagcagactgcc ggtaacgcgcggccggggcgggagagactcagcaacgacccatacctcagacccgacggc ccggagcggacgccctgctgccgacgccagagccgccgcgtgcccgctgcagtttcttgg acatagaccaaagaagctacagcctggacttaccaccactaaactgcgagagaagctaaa cgtgtttattttcccttaaattatttttgtaatggtagctttttctacatcttactcctg ttgatgcagctaaggtacatttgtaaaaagaaaaaaaaccagacttttcagacaaaccct ttgtattgtagataagagg >1058_at HG-U95AV2 ctaagcttttctctcatagcgtagacctagggaagggatgggaagattgcccagtccccg atggctgcgcacacaggaggcggcggacgacaaggcaagtgagtttgcactgtcagcccc agaccgtaagcttggctacactgatgtttttctttactaaggatactattcaaaaattaaagttcttcaagcagctgcccagcccgcccttcctgccggcc ^ ccgggacagcagactgcc ggtaacgcgcggccggggcgggagagactcagcaacgacccatacctcagacccgacggc ccggagcggacgccctgctgccgacgccagagccgccgcgtgcccgctgcagtttcttgg acatagaccaaagaagctacagcctggacttaccaccactaaactgcgagagaagctaaa cgtgtttattttcccttaaattatttttgtaatggtagctttttctacatcttactcctg ttgatgcagctaaggtacatttgtaaaaagaaaaaaaaccagacttttcagacaaaccct ttgtattgtagataagagg > 1058_at HG-U95AV2 ctaagcttttctctcatagcgtagacctagggaagggatgggaagattgcccagtccccg atggctgcgcacacaggaggcggcggacgacaaggcaagtgagtttgcactgtcagcccc agaccgtaagcttggctacactgatgtttttctttactaaggatactattcaaaaattaa

cattttcatctcagtaagtttttagaacatcaaaatgttttctgagctccaagtggctag gttgtaaaagttttataataatttgcaattaaaatacatgatacatattaatccattaaa gactagtgggaatgtatcagccagagtagcaagtaatttttgttttataaatcatagtat ctgtcatcttgcagtattaccaatgctgttgtaaattgaatttaaagtggtattaaaaaa aactgttaaacaatttttatctgtttgtatatcttactataga >1061_at HG-U95Av2 tcatgccaagacagtatcagacacagccccagaagggggcattatgggccctgcctcccc ataggccatttggactctgccttcaaacaaaggcagttcagtccacaggcatggaagctg tgaggggacaggcctgtgcgtgccatccagagtcatctcagccctgcctttctctggagc attctgaaaacagatattctggcccagggaatccagccatgacccccacccctctgccaa agtactcttaggtgccagtctggtaactgaactccctctggaggcaggcttgagg >1069_at HG-U95AV2 ggttgaatgtttgtccttaggataggcctatgtgctagcccacaaagaatattgtctcat tagcctgaatgtgccataagactgaccttttaaaatgttttgagggatctgtggatgctt cgttaatttgttcagccacaatttattgagaaaatattctgtgtcaagcactgtgggttt taatatttttaaatcaaacgctgattacagataatagtatttatataaataattgaaaaa sattttcttttgggaagagggagdda^dtgdaataadtsitcdttaaagataactcaggdga atcttctttacaa >1086_at HG-U95AV2 agatgtgtccccaacatccccacagcccgagggcctccttgtcctgcagcaagtgggcga ctattgcttcctccccggcctggggcccggccctctctcgctccggagtaaaccttcttc cccgggacccggtcctgagatcaagaacctagaccaggcttttcaagtcaagaagccccc aggccaggctgtgccccaggtgcccgtcattcagctcttcaaagccctgaagcagcagga ctacctgtctctgcccccttgggaggtcaacaagcctggggaggtgtgttgagaccccca ggcctagacaggcaaggggatggagagggcttgccttccctcccgcctgaccttcctcag tcatttctgcaaagccaaggggcagcctcctgtcaaggtagctagaggcctgggaaagga gatagccttgctccggcccccttgaccttcagcaaatcacttctctccctgcgctcacac 55- 98677.doc 200533758 agacacacacacacacacgtacatgcacacatttttcctgtcaggttaa >1102_s_at HG-U95AV2 gtgaaggttgctgaggctctgacccagtgagattacagaggaagttatcctctgcctccc attctgaccacccttctcattccaacagtgagtctgtcagcgcaggtttagtttactcaa tctccccttgcactaaagtatgtaaagtatgtaaacaggagacaggaaggtggtgcttac atccttaaaggcaccatctaatagcgggttactttcacatacagccctcccccagcagtt gaatgacaacagaagcttcagaagtttggcaatagtttgcatagaggtaccagcaatatg taaatagtgcagaatctcataggttgccaataatacactaattcctttctatcctacaac aagagttta >110 5__s__at HG-U9 5AV2 ctagctccaaaaccatcccaggtcattcttcatcctcacccaggattctcctgtacctgc tcccaatctgtgttcctaaaagtgattctcactctgcttctcatctcctacttacatgaa tacttctctctt >1113一at HG-U95AV2 aagatgaacacagctggtcacagataaggccattgctagtaacttttggccatgatggaa aagggcatcctctccacaaaagagaaaaacgtcaagccaaacacaaacagcggaaacgcccattttcatctcagtaagtttttagaacatcaaaatgttttctgagctccaagtggctag gttgtaaaagttttataataatttgcaattaaaatacatgatacatattaatccattaaa gactagtgggaatgtatcagccagagtagcaagtaatttttgttttataaatcatagtat ctgtcatcttgcagtattaccaatgctgttgtaaattgaatttaaagtggtattaaaaaa aactgttaaacaatttttatctgtttgtatatcttactataga > 1061_at HG-U95Av2 tcatgccaagacagtatcagacacagccccagaagggggcattatgggccctgcctcccc ataggccatttggactctgccttcaaacaaaggcagttcagtccacaggcatggaagctg tgaggggacaggcctgtgcgtgccatccagagtcatctcagccctgcctttctctggagc attctgaaaacagatattctggcccagggaatccagccatgacccccacccctctgccaa agtactcttaggtgccagtctggtaactgaactccctctggaggcaggcttgagg > 1069_at HG-U95AV2 ggttgaatgtttgtccttaggataggcctatgtgctagcccacaaagaatattgtctcat tagcctgaatgtgccataagactgaccttttaaaatgttttgagggatctgtggatgctt cgttaatttgttcagccacaatttattgagaaaatattctgtgtcaagcactgtgggttt taatatttttaaatcaaacgctgattacagataatagtatttatataaataattgaaaaa sattttcttttgggaagagggagdda ^ dtgdaataadtsitcdttaaagataactcaggdga atcttctttacaa > 1086_at HG-U95AV2 agatgtgtccccaacatccccacag cccgagggcctccttgtcctgcagcaagtgggcga ctattgcttcctccccggcctggggcccggccctctctcgctccggagtaaaccttcttc cccgggacccggtcctgagatcaagaacctagaccaggcttttcaagtcaagaagccccc aggccaggctgtgccccaggtgcccgtcattcagctcttcaaagccctgaagcagcagga ctacctgtctctgcccccttgggaggtcaacaagcctggggaggtgtgttgagaccccca ggcctagacaggcaaggggatggagagggcttgccttccctcccgcctgaccttcctcag tcatttctgcaaagccaaggggcagcctcctgtcaaggtagctagaggcctgggaaagga gatagccttgctccggcccccttgaccttcagcaaatcacttctctccctgcgctcacac 55- 98677.doc 200533758 agacacacacacacacacgtacatgcacacatttttcctgtcaggttaa > 1102_s_at HG-U95AV2 gtgaaggttgctgaggctctgacccagtgagattacagaggaagttatcctctgcctccc attctgaccacccttctcattccaacagtgagtctgtcagcgcaggtttagtttactcaa tctccccttgcactaaagtatgtaaagtatgtaaacaggagacaggaaggtggtgcttac atccttaaaggcaccatctaatagcgggttactttcacatacagccctcccccagcagtt gaatgacaacagaagcttcagaagtttggcaatagtttgcatagaggtaccagcaatatg taaatagtgcagaatctcataggttgccaataatacactaattcctttctatcctacaac aagagttta > 110 5__s__at HG-U9 5AV2 ctagctccaaaaccatcccaggtcattcttcatcc tcacccaggattctcctgtacctgc tcccaatctgtgttcctaaaagtgattctcactctgcttctcatctcctacttacatgaa tacttctctctt > 1113 one at HG-U95AV2 aagatgaacacagctggtcacagagagggccattgctagtaacttttcccacagacaccagagaccagat

ttaagtccagctgtaagagacaccctttgtacgtggacttcagtgacgtggggtggaatg actggattgtggctcccccggggtatcacgccttttactgccacggagaatgcccttttc ctctggctgatcatctgaactccactaatcatgccattgttcagacgttggtcaactctg ttaactctaagattcctaaggcatgctgtgtcccgacagaactcagtgctatctcgatgc tgtaccttgacgagaatgaaaaggttgtattaaagaactatcaggacatggttgtggagg gttgtgggtgtcgctagtacagcaaaattaa >1114_at HG-U95AV2 caggattagccgatcgttacctcaagggagtgggaattgggcccagctccggcccctcct ggtcacctttggccatgatggccggggccatgccttgacccgacgccggagggccaagcg tagccctaagcatcactcacagcgggccaggaagaagaataagaactgccggcgccactc gctctatgtggacttcagcgatgtgggctggaatgactggattgtggccccaccaggcta ccaggccttctactgccatggggactgcccctttccactggctgaccacctcaactcaac caaccatgccattgtgcagaccctggtcaattctgtcaattccagtatccccaaagcctg ttgtgtgcccactgaactgagtgccatctccatgctgtacctggatgagtatgataaggt ggtactgaaaaattatcaggagatggtagtagagggatgtgggtgccgctgagatcaggc agtccttgaggatagacagatatac >1126_s_at HG-U95Av2 aaagctagtgatcaacagtggcaatggagctgtggaggacagaaagccaagtggactcaa cggagaggccagcaagtctcaggaaatggtgcatttggtgaacaaggagtcgtcagaaac tccagaccagtttatgacagctgatgagacaaggaacctgcagaatgt >1173_g_at HG-U95Av2 TIGRSequence >1184_at HG-U95AV2 tcagctcttgcaagaggactccctcaatgtggctgacttgacttccctccgggccccact ggacatccccatcccagaccctccacccaaggatgatgagatggaaacagataagcagga gaagaaagaagtccctaagtgtggatttctccctgggaatgagaaagtcctgtccctgct tgccctggttaagccagaagtctggactctcaaagagaaatgcattctggtgattacatg gatccaacacctgatccccaagattgaagatggaaatgattttggggtagcaatccagga gaaggtgctggagagggtgaatgccgtcaagaccaaagtggaagctttccagacaaccat ttccaagtacttctcagaacgtggggatgctgtggccaaggcctccaaggagactcatgt aatggattaccgggccttggtgcatgagcgagatgaggcagcctatggggagctcagggc catggtgctggacctgagggccttctatgctgagctttatcatatcatcagcagcaacct ggagaaa >1207_at HG-U95Av2 ttctccgaggtctggactttcttcattcacaccgagtagtgcatcgcgatctaaaaccac agaacattctggtgaccagcagcggacaaataaaactcgctgacttcggccttgcccgca tctatagtttccagatggctctaacctcagtggtcgtcacgctgtggtacagagcacccg 56- 98677.doc 200533758 aagtcttgctccagtccagctacgccacccccgtggatctctggagtgttggctgcatat ttgcagaaatgtttcgtagaaagcctctttttcgtggaagttcagatgttgatcaactag gaaaaatcttggacgtgattggactcccaggagaagaagactggcctagagatgttgccc ttcccaggcaggcttttcattcaaaatctgcccaacc >120_at HG-U95AV2 tgacatcaaatggttaccctgtgctgtacccaactggattgtcatcttctgagaatgcaa actgcagaccccatatctttgaggatcctttcagtatcaactctggaaagaaaatgacta catcaactgaccatctcaaacgaggcacaattctggactgcaatacatgtaaatttgcta ccatcacatgtaatctcacttcttctgacatcagccaagtcaatgtttcgcttatcttgt ggaaaccaacttttataaaatcatatttttccagcttaaatcttactataaggggagaac ttcggagtgaaaatgcatctctggttttaagtagcagcaatcaaaaaagagagcttgcta ttcaaatatccaaagatgggctaccgggcagagtgccattatgggtcatcctgctgagtg cttttgccggattgttgctgttaatgctgctcattttagcactgtggaagattggattct t >1212_at HG-U95AV2ttaagtccagctgtaagagacaccctttgtacgtggacttcagtgacgtggggtggaatg actggattgtggctcccccggggtatcacgccttttactgccacggagaatgcccttttc ctctggctgatcatctgaactccactaatcatgccattgttcagacgttggtcaactctg ttaactctaagattcctaaggcatgctgtgtcccgacagaactcagtgctatctcgatgc tgtaccttgacgagaatgaaaaggttgtattaaagaactatcaggacatggttgtggagg gttgtgggtgtcgctagtacagcaaaattaa > 1114_at HG-U95AV2 caggattagccgatcgttacctcaagggagtgggaattgggcccagctccggcccctcct ggtcacctttggccatgatggccggggccatgccttgacccgacgccggagggccaagcg tagccctaagcatcactcacagcgggccaggaagaagaataagaactgccggcgccactc gctctatgtggacttcagcgatgtgggctggaatgactggattgtggccccaccaggcta ccaggccttctactgccatggggactgcccctttccactggctgaccacctcaactcaac caaccatgccattgtgcagaccctggtcaattctgtcaattccagtatccccaaagcctg ttgtgtgcccactgaactgagtgccatctccatgctgtacctggatgagtatgataaggt ggtactgaaaaattatcaggagatggtagtagagggatgtgggtgccgctgagatcaggc agtccttgaggatagacagatatac > 1126_s_at HG-U95Av2 aaagctagtgatcaacagtggcaatggagctgtggaggacagaaagccaagtggactcaa cggagaggccagcaagtctcaggaaatggtgcatttggtgaa caaggagtcgtcagaaac tccagaccagtttatgacagctgatgagacaaggaacctgcagaatgt > 1173_g_at HG-U95Av2 TIGRSequence > 1184_at HG-U95AV2 tcagctcttgcaagaggactccctcaatgtggctgacttgacttccctccgggccccact ggacatccccatcccagaccctccacccaaggatgatgagatggaaacagataagcagga gaagaaagaagtccctaagtgtggatttctccctgggaatgagaaagtcctgtccctgct tgccctggttaagccagaagtctggactctcaaagagaaatgcattctggtgattacatg gatccaacacctgatccccaagattgaagatggaaatgattttggggtagcaatccagga gaaggtgctggagagggtgaatgccgtcaagaccaaagtggaagctttccagacaaccat ttccaagtacttctcagaacgtggggatgctgtggccaaggcctccaaggagactcatgt aatggattaccgggccttggtgcatgagcgagatgaggcagcctatggggagctcagggc catggtgctggacctgagggccttctatgctgagctttatcatatcatcagcagcaacct ggagaaa > 1207_at HG-U95Av2 ttctccgaggtctggactttcttcattcacaccgagtagtgcatcgcgatctaaaaccac agaacattctggtgaccagcagcggacaaataaaactcgctgacttcggccttgcccgca tctatagtttccagatggctctaacctcagtggtcgtcacgctgtggtacagagcacccg 56- 98677.doc 200533758 aagtcttgctccagtccagctacgccacccccgtggatctctggagtgttggctgcatat ttgcagaaatgtttcgtagaaagcct ctttttcgtggaagttcagatgttgatcaactag gaaaaatcttggacgtgattggactcccaggagaagaagactggcctagagatgttgccc ttcccaggcaggcttttcattcaaaatctgcccaacc > 120_at HG-U95AV2 tgacatcaaatggttaccctgtgctgtacccaactggattgtcatcttctgagaatgcaa actgcagaccccatatctttgaggatcctttcagtatcaactctggaaagaaaatgacta catcaactgaccatctcaaacgaggcacaattctggactgcaatacatgtaaatttgcta ccatcacatgtaatctcacttcttctgacatcagccaagtcaatgtttcgcttatcttgt ggaaaccaacttttataaaatcatatttttccagcttaaatcttactataaggggagaac ttcggagtgaaaatgcatctctggttttaagtagcagcaatcaaaaaagagagcttgcta ttcaaatatccaaagatgggctaccgggcagagtgccattatgggtcatcctgctgagtg cttttgccggattgttgctgttaatgctgctcattttagcactgtggaagattggattct t > 1212_at HG-U95AV2

gccctggagcagatcctacagagcacagcgggcatatactgtgtaggagacgaggtgacc atggctgatctgtgcttggtgcctcaggtggcaaatgctgaaagattcaaggtggatctc accccctaccctaccatcagetccatcaacaagaggctgctggtcttggaggccttccag gtgtctcacccctgccggcagccagatacacccactgagctgagggcctagctcccaaat cctgccccgttggcacagggccacaggagcagaagctgggtgggctgaagaggcctggaa acgagagtcttaattgaggagatgggagactcgaactctagccctggatctgccttcctg ctgaaacttgttccacctcagtcccctcatctgtcacacgcatgtggggtggagtaggga gatgcggggagcagggtgggcaggaatactgttatctatgtgacggggcagtcgtgaggc tgagatgagaatgcggattaaaatgcctggcgtgctcaccgtaacaccacggggaaggct gtgtgccttttctcatccgcttttgttgtgtgtgactccaaagaatgcccgcgct >122 3__at HG-U9 5AV2 gcgtgaccgccttctctgagttccgcacctacagcttcccctgctacctcccgcagccgc tcatcaaccacgcgcccaggttggatacggatggcatccacctcctgagcagcctgctcg tgtatgaatccaagagtcgcatgtcagcagaggctgccctgagtcactcctacttccggt ctctgggagagcgtgtgcaccagcttgaagacactgcctccatcttctccctgaaggaga tccagctccagaaggacccaggctaccgaggcttggccttccagcagccaggacgaggga a >1226_at HG-U95Av2 ttatattgataacagcactgactagggaaatgatcagttttttttttatacactgtaatg aaccgctgaatatgaggcatttggc >1227_g_at HG-U95Av2 aactggaccaccagagaatggacaccatccaggaagaccccagcacagactcacatatgg acgaggatgggtttgagaaggaccccttcccaaatagcagcacagctgccaagtcatttg aggatctcacggaccatccggtcaccagaagtgaaaaggctgcctcctttaaactgcagc gtcagaatcgtgttgacagcaaagaaacagagtgctaatttagttctcagctcttctgac ttaagtgtgcaaaatatttttatagatttgacctacaatcaatcacagcttatattttgt gaagactgggaagtgacttagcagatgctggtcatgt >1237_at HG-U95Av2 agaccgaggcgcatagagaccgageacagcccagetgggctaggcccggtgggaaggaga gcgtcgttaatttatttcttattgctcctaattaatatttatatgtatttatgtacgtcc tcctaggtgatgagatgtgtacgtaatatttattttaacttatgcaagggtgtgagatgt tccccctgctgtaaatgcaggtctcttggtatttattgagctttgtgggactggtggaag caggacacctggaactgcggcaaagtaggagaagaaatggggaggactcgggtgggggag gacgtcccggctgggatgaagtctggtggtgggtcgtaagtttaggaggtgactgcatcc tccagcattctcaactccgtctgtctactgtgtgagacttcggcggaccattaggaatga gatccgtgagatccttccatcttcttgaagtcgcctttagggtggctgcgaggtagaggg ttgggggttggtgggctgtcacggagcgactgtcgagatcgcctagtatgttctgtgaac acaaata >1278 at HG-U95Av2 57- 9867'doc 200533758 TIGRSequence >128_at HG-U95AV2 cctacccatatgtgggacaggaagagagttgtatgtacaacccaacaggcaaggcagcta aatgcagagggtacagagagatccccgaggggaatgagaaagccctgaagagggcagtgg cccgagtgggacctgtctctgtggccattgatgcaagcctgacctccttccagttttaca gcaaaggtgtgtattatgatgaaagctgcaatagcgataatctgaaccatgcggttttgg cagtgggatatggaatccagaagggaaacaagcactggataattaaaaacagctggggag aaaactggggaaacaaaggatatatcctcatggctcgaaataagaacaacgcctgtggca ttgccaacctggc >129_g_at HG-U95Av2 agactctgtcgactatcgaaagaaaggatatgttactcctgtcaaaaatcagggtcagtg tggttcctgttgggcttttagctctgtgggtgccctggagggccaactcaagaagaaaac tggcaaactcttaaatctgagtccccagaacctagtggattgtgtgtctgagaatgatgg ctgtggagggggctacatgaccaatgccttccaatatgtgcagaagaa >1334_s—at HG-U95Av2gccctggagcagatcctacagagcacagcgggcatatactgtgtaggagacgaggtgacc atggctgatctgtgcttggtgcctcaggtggcaaatgctgaaagattcaaggtggatctc accccctaccctaccatcagetccatcaacaagaggctgctggtcttggaggccttccag gtgtctcacccctgccggcagccagatacacccactgagctgagggcctagctcccaaat cctgccccgttggcacagggccacaggagcagaagctgggtgggctgaagaggcctggaa acgagagtcttaattgaggagatgggagactcgaactctagccctggatctgccttcctg ctgaaacttgttccacctcagtcccctcatctgtcacacgcatgtggggtggagtaggga gatgcggggagcagggtgggcaggaatactgttatctatgtgacggggcagtcgtgaggc tgagatgagaatgcggattaaaatgcctggcgtgctcaccgtaacaccacggggaaggct gtgtgccttttctcatccgcttttgttgtgtgtgactccaaagaatgcccgcgct > 122 3__at HG-U9 5AV2 gcgtgaccgccttctctgagttccgcacctacagcttcccctgctacctcccgcagccgc tcatcaaccacgcgcccaggttggatacggatggcatccacctcctgagcagcctgctcg tgtatgaatccaagagtcgcatgtcagcagaggctgccctgagtcactcctacttccggt ctctgggagagcgtgtgcaccagcttgaagacactgcctccatcttctccctgaaggaga tccagctccagaaggacccaggctaccgaggcttggccttccagcagccaggacgaggga a > 1226_at HG-U95Av2 ttatattgataacagcactgactagggaaatgatcagtttt ttttttatacactgtaatg aaccgctgaatatgaggcatttggc > 1227_g_at HG-U95Av2 aactggaccaccagagaatggacaccatccaggaagaccccagcacagactcacatatgg acgaggatgggtttgagaaggaccccttcccaaatagcagcacagctgccaagtcatttg aggatctcacggaccatccggtcaccagaagtgaaaaggctgcctcctttaaactgcagc gtcagaatcgtgttgacagcaaagaaacagagtgctaatttagttctcagctcttctgac ttaagtgtgcaaaatatttttatagatttgacctacaatcaatcacagcttatattttgt gaagactgggaagtgacttagcagatgctggtcatgt > 1237_at HG-U95Av2 agaccgaggcgcatagagaccgageacagcccagetgggctaggcccggtgggaaggaga gcgtcgttaatttatttcttattgctcctaattaatatttatatgtatttatgtacgtcc tcctaggtgatgagatgtgtacgtaatatttattttaacttatgcaagggtgtgagatgt tccccctgctgtaaatgcaggtctcttggtatttattgagctttgtgggactggtggaag caggacacctggaactgcggcaaagtaggagaagaaatggggaggactcgggtgggggag gacgtcccggctgggatgaagtctggtggtgggtcgtaagtttaggaggtgactgcatcc tccagcattctcaactccgtctgtctactgtgtgagacttcggcggaccattaggaatga gatccgtgagatccttccatcttcttgaagtcgcctttagggtggctgcgaggtagaggg ttgggggttggtgggctgtcacggagcgactgtcgagatcgcctagtatgttctgtgaac acaaata > 1278 at HG-U95Av2 57- 9867'doc 200533758 TIGRSequence > 128_at HG-U95AV2 cctacccatatgtgggacaggaagagagttgtatgtacaacccaacaggcaaggcagcta aatgcagagggtacagagagatccccgaggggaatgagaaagccctgaagagggcagtgg cccgagtgggacctgtctctgtggccattgatgcaagcctgacctccttccagttttaca gcaaaggtgtgtattatgatgaaagctgcaatagcgataatctgaaccatgcggttttgg cagtgggatatggaatccagaagggaaacaagcactggataattaaaaacagctggggag aaaactggggaaacaaaggatatatcctcatggctcgaaataagaacaacgcctgtggca ttgccaacctggc > 129_g_at HG-U95Av2 agactctgtcgactatcgaaagaaaggatatgttactcctgtcaaaaatcagggtcagtg tggttcctgttgggcttttagctctgtgggtgccctggagggccaactcaagaagaaaac tggcaaactcttaaatctgagtccccagaacctagtggattgtgtgtctgagaatgatgg ctgtggagggggctacatgaccaatgccttccaatatgtgcagaagaa > 1334_s-at HG-U95Av2

atttattactatgactgctccccagccctggctctgcaatgggcactgggatgagccgct gtgagcccctggtcctgagggtccccacctgggacccttgagagtatcaggtctcccacg tgggagacaagaaatccctgtttaatatttaaacagcagtgttccccatctgggtccttg cacccctcactctggcctcagccgactgcacagcggcccctgcatccccttggctgtgag gcccctggacaagcagaggtggccagagctgggaggcatggccctggggtcccacgaatt tgctggggaatctcgtttttcttcttaagacttttgggacatggtttgactcccgaacat caccgacgtgtctcctgtttttctgggtggcctcgggacacctgccctgcccccacgagg gtcaggactgtgactctttttagggccaggcaggtgcctggacatttgccttgctggatg gggactggggatgtgggagggagcagacaggaggaatcatgtcaggcctgtgtgtgaaag gaagctccactgtcaccctc >1369_s__at HG-U95AV2 ttttcctagatattgcacgggagaatatacaaatagcaaaattgggccaagggccaagag aatatccgaactttaatttcaggaattgaatgggtttgctagaatgtgatatttgaagca tcacataaaaatgatgggacaataaattttgccataaagtcaaatttagctggaaatcct ggatttttttctgttaaatctggcaaccctagtctgctagccaggatccacaagtccttg ttccactgtgccttggtttctcctttatttctaagtggaaaaagtattagccaccatctt acctcacagtgatgttgtgaggacatgtggaagcactttaagttttttcatcataacata a >1370_at HG-U95AV2 cccatctgaggatgtagtcgtcactccagaaagctttggaagagattcatccctcacatg cctggctgggaatgtcagtgcatgtgacgcccctattctctcctcttccaggtccctaga ctgcagggagagtggcaagaatgggcctcatgtgtaccaggacctcctgcttagccttgg gactacaaacagcacgctgccccctccattttctctccaatctggaatcctgacattgaa cccagttgctcagggtcagcccattcttacttccctgggatcaaatcaagaagaagcata tgtcaccatgtccagcttctaccaaaaccagtgaagtgtaagaaacccagactgaactta ccgtgagcgacaaagatgatttaaaagggaagtctagagttcctagtctccctcacagca cagagaagacaaaattagcaaaaccccactacacagtctgcaagattctgaaacattgct ttgaccactcttcctgagttcagtggcactcaacatgagtcaagagcatcctgcttctac catgtggatttgg >1372_at HG-U95Av2 atcttttggaactcctttgatctcactgttattattaacatttatttattatttttctaa atgtgaaagaaatacataatttagggaaaattggaaaatataggaaactttaaacgagaa aatgaaacctctcataatcccactgcatagaaataacaagcgttaacattttcatatttt tttctttcagtcatttttgtatttgtggtatatgtatatatgtacctatatgtatttgca tttgaaattttggaatcctgctctatgtacagttttgtattatactttttaaatcttgaa ctttatgaacattttctgaaatcattgattattctacaaaaacatgattttaaacagctg taaaatattctatgatatgaatgttttatgcattatttaagcctgtctctattgttggaa tttcaggtcattt >1377 at HG-U95Av2 58- 98677.doc 200533758 gtccacaagacagaagctgaagtgcatccaaaggtgctcagagagccggcccgcctgaat cattctcgatttaactcgagaccttttcaacttggcttcctttcttggttcataaatgaa ttttagtttggttcacttacagatagtatctagcaatcacaacactggctgagcggatgc atctggggatgaggttgcttactaagctttgccagctgctgctggatcacagctgctttc tgttgtc >1378_g_at HG-U95Av2 agcccagtgaagaccacctctcaggcccactcgctgcctctctcgcctgcctccacaagg cagcaaatagacgagctccgagacagtgacagtgtctgcgacacgggcgtggagacatcc ttccgcaaactcagctttaccgagtctctgaccagtggtgcctcactgctaactctcaac aaaatgccccatgattatgggcaggaaggacctctagaaggcaaaatttagcctgctgac aatt >1385_at HG-U95Av2 tgaagcactacaggaggaatgcaccacggcagctctccgccaatttctctcagatttcca cagagactgtttgaatgttttcaaaaccaagtatcacactttaatgtacatgggccgcac cataatgagatgtgagccttgtgcatgtgggggaggagggagagagatgtactttttaaa tcatgttccccctaaacatggctgttaacccactgcatgcagaaacttggatgtcactgcatttattactatgactgctccccagccctggctctgcaatgggcactgggatgagccgct gtgagcccctggtcctgagggtccccacctgggacccttgagagtatcaggtctcccacg tgggagacaagaaatccctgtttaatatttaaacagcagtgttccccatctgggtccttg cacccctcactctggcctcagccgactgcacagcggcccctgcatccccttggctgtgag gcccctggacaagcagaggtggccagagctgggaggcatggccctggggtcccacgaatt tgctggggaatctcgtttttcttcttaagacttttgggacatggtttgactcccgaacat caccgacgtgtctcctgtttttctgggtggcctcgggacacctgccctgcccccacgagg gtcaggactgtgactctttttagggccaggcaggtgcctggacatttgccttgctggatg gggactggggatgtgggagggagcagacaggaggaatcatgtcaggcctgtgtgtgaaag gaagctccactgtcaccctc > 1369_s__at HG-U95AV2 ttttcctagatattgcacgggagaatatacaaatagcaaaattgggccaagggccaagag aatatccgaactttaatttcaggaattgaatgggtttgctagaatgtgatatttgaagca tcacataaaaatgatgggacaataaattttgccataaagtcaaatttagctggaaatcct ggatttttttctgttaaatctggcaaccctagtctgctagccaggatccacaagtccttg ttccactgtgccttggtttctcctttatttctaagtggaaaaagtattagccaccatctt acctcacagtgatgttgtgaggacatgtggaagcactttaagttttttcatcataacata a > 1370_at HG-U95AV2 cccatctgaggatgt agtcgtcactccagaaagctttggaagagattcatccctcacatg cctggctgggaatgtcagtgcatgtgacgcccctattctctcctcttccaggtccctaga ctgcagggagagtggcaagaatgggcctcatgtgtaccaggacctcctgcttagccttgg gactacaaacagcacgctgccccctccattttctctccaatctggaatcctgacattgaa cccagttgctcagggtcagcccattcttacttccctgggatcaaatcaagaagaagcata tgtcaccatgtccagcttctaccaaaaccagtgaagtgtaagaaacccagactgaactta ccgtgagcgacaaagatgatttaaaagggaagtctagagttcctagtctccctcacagca cagagaagacaaaattagcaaaaccccactacacagtctgcaagattctgaaacattgct ttgaccactcttcctgagttcagtggcactcaacatgagtcaagagcatcctgcttctac catgtggatttgg > 1372_at HG-U95Av2 atcttttggaactcctttgatctcactgttattattaacatttatttattatttttctaa atgtgaaagaaatacataatttagggaaaattggaaaatataggaaactttaaacgagaa aatgaaacctctcataatcccactgcatagaaataacaagcgttaacattttcatatttt tttctttcagtcatttttgtatttgtggtatatgtatatatgtacctatatgtatttgca tttgaaattttggaatcctgctctatgtacagttttgtattatactttttaaatcttgaa ctttatgaacattttctgaaatcattgattattctacaaaaacatgattttaaacagctg taaaatattctatgatatgaatgttttatgcattatttaagcctgtctctattgttggaa ttt caggtcattt > 1377 at HG-U95Av2 58- 98677.doc 200533758 gtccacaagacagaagctgaagtgcatccaaaggtgctcagagagccggcccgcctgaat cattctcgatttaactcgagaccttttcaacttggcttcctttcttggttcataaatgaa ttttagtttggttcacttacagatagtatctagcaatcacaacactggctgagcggatgc atctggggatgaggttgcttactaagctttgccagctgctgctggatcacagctgctttc tgttgtc > 1378_g_at HG-U95Av2 agcccagtgaagaccacctctcaggcccactcgctgcctctctcgcctgcctccacaagg cagcaaatagacgagctccgagacagtgacagtgtctgcgacacgggcgtggagacatcc ttccgcaaactcagctttaccgagtctctgaccagtggtgcctcactgctaactctcaac aaaatgccccatgattatgggcaggaaggacctctagaaggcaaaatttagcctgctgac aatt > 1385_at HG-U95Av2 tgaagcactacaggaggaatgcaccacggcagctctccgccaatttctctcagatttcca cagagactgtttgaatgttttcaaaaccaagtatcacactttaatgtacatgggccgcac cataatgagatgtgagccttgtgcatgtgggggaggagggagagagatgtactttttaaa tcatgttccccctaaacatggctgttaacccactgcatgcagaaacttggatgtcactgc

ctgacattcacttccagagaggacctatcccaaatgtggaattgactgcctatgccaagt ccctggaaaaggagcttcagtattgtggggctcataaaacatgaatcaagcaatccagcc tcatgggaagtcctggcacagtttttgtaaagcccttgcacagctggagaaatggcatca ttataagctatgagttgaaatgttctgtcaaatgtgtctcacatctacacgtggcttgga ggcttttatggggccctgtccaggtagaaaagaaatggtatgtagagcttagatttccct attgtgacagagccatggtgtgtttgtaata >1400__at HG-U95Av2 tctcctgaacctgagtagagacactgctgctgagatgaatgaaacagtagaagtcatctc agaaatgtttgacctccaggagccgacctgcctacagacccgcctggagctgtacaagca gggcctgcggggcagectcaccaagctcaagggccccttgaccatgatggccagccacta caagcagcactgccctccaaccccggaaacttcctgtgcaacccagattatcacctttga aagtttcaaagagaacctgaaggactttctgcttgtc >1401_g_at HG-U95Av2 cctgaaggactttctgcttgtcatcccctttgactgctgggagccagtccaggagtgaga ccggccagatgaggctggccaagccggggagctgctctctcatgaaacaagagctagaaa ctcaggatggtcatcttggagggaccaaggggtgggccacagccatggtgggagtggcct ggacctgccctgggccacactgaccctgatacaggcatggcagaagaatgggaatatttt atactgacagaaatcagtaatatttatatatttatatttttaaaatatttatttatttat ttatttaagttcatattccatatttattcaagatgttttaccgtaata >1402_at HG-U95Av2 ttgcacttatgatttcatgtgcggggatcatctgccgtgcctggatcctgaaatagaggc taaattactcaggaagaacaccctctaaatgggaaagtattctgtactettagatggatt ctccactcagttgcaacttggacttgtcctcagcagctggtaatcttgctctgcttgaca acatctgagtgcagccgtttgagaagaaaacatctattctctccaaaaatgcacccaact agctctatgtttacaaatggacataggactcaaagtttcagagaccattgcaatgaatcc ccaataattgcdgaactaadctcatttataa >1403_s_at HG-U95Av2 gagcttctgaggcgctgctttgtcaaaaggaagtctctaggttctgagctctggctttgc ettg >1405_i_at HG-U95Av2 agcttccccaactaaagcctagaagagcttctgaggcgctgctttg >1433_g_at HG-U95Av2 cctctcagaacatactgattgggaggtgcgtgttcagcagaacctgcacacaggacagcg ggaaaaatcgatgagcgccacctctttaaaaactcacttacgttgtcctttttcactttg aaaagttggaaggactgctgaggcccagtgcatatgcaatgtatagtgtctattatcaca ttaatctcaaagagattcgaatgacggtaagtgttctcatgaagcaggaggcccttgtcg tgggatggcatttggtctcaggcagcaccacactgggtgcgtctccagtcatctgtaaga 59- 98677.doc 200533758 gcttgctccagattctgatgcatacggctatattggtttatgtagtcagttgcattcatt a >1451_s_at HG-U95AV2 gttgacttcaggaactgaaacatcagcacaaagaagcaatcatcaaataattctgaacac aaatttaatatttttttttctgaatgagaaacatgagggaaattgtggagttagcctcct gtggtaaaggaattgaagaaaatataacaccttacaccctttttcatcttgacattaaaa gttctggctaactttggaatccattagagaaaaatccttgtcaccagattcattacaatt caaatcgaagagttgtgaactgttatcccattgaaaagaccgagccttgtatgtatgtta tggatacataaaatgcacgcaagccattatctctccatgggaagctaagttataaaaata ggtgcttggtgtacaaaactttttatatcaaaaggctttgcacatttctatatgagtggg tttactggtaaattatgttattttttacaactaattttgtactctcagaatgtttgtcat atgcttcttgcaatgcata >1457__at HG-U95Av2ctgacattcacttccagagaggacctatcccaaatgtggaattgactgcctatgccaagt ccctggaaaaggagcttcagtattgtggggctcataaaacatgaatcaagcaatccagcc tcatgggaagtcctggcacagtttttgtaaagcccttgcacagctggagaaatggcatca ttataagctatgagttgaaatgttctgtcaaatgtgtctcacatctacacgtggcttgga ggcttttatggggccctgtccaggtagaaaagaaatggtatgtagagcttagatttccct attgtgacagagccatggtgtgtttgtaata > 1400__at HG-U95Av2 tctcctgaacctgagtagagacactgctgctgagatgaatgaaacagtagaagtcatctc agaaatgtttgacctccaggagccgacctgcctacagacccgcctggagctgtacaagca gggcctgcggggcagectcaccaagctcaagggccccttgaccatgatggccagccacta caagcagcactgccctccaaccccggaaacttcctgtgcaacccagattatcacctttga aagtttcaaagagaacctgaaggactttctgcttgtc > 1401_g_at HG-U95Av2 cctgaaggactttctgcttgtcatcccctttgactgctgggagccagtccaggagtgaga ccggccagatgaggctggccaagccggggagctgctctctcatgaaacaagagctagaaa ctcaggatggtcatcttggagggaccaaggggtgggccacagccatggtgggagtggcct ggacctgccctgggccacactgaccctgatacaggcatggcagaagaatgggaatatttt atactgacagaaatcagtaatatttatatatttatatttttaaaatatttatttatttat ttatttaagttcatattccatatttattc aagatgttttaccgtaata > 1402_at HG-U95Av2 ttgcacttatgatttcatgtgcggggatcatctgccgtgcctggatcctgaaatagaggc taaattactcaggaagaacaccctctaaatgggaaagtattctgtactettagatggatt ctccactcagttgcaacttggacttgtcctcagcagctggtaatcttgctctgcttgaca acatctgagtgcagccgtttgagaagaaaacatctattctctccaaaaatgcacccaact agctctatgtttacaaatggacataggactcaaagtttcagagaccattgcaatgaatcc ccaataattgcdgaactaadctcatttataa > 1403_s_at HG-U95Av2 gagcttctgaggcgctgctttgtcaaaaggaagtctctaggttctgagctctggctttgc ettg > 1405_i_at HG-U95Av2 agcttccccaactaaagcctagaagagcttctgaggcgctgctttg > 1433_g_at HG-U95Av2 cctctcagaacatactgattgggaggtgcgtgttcagcagaacctgcacacaggacagcg ggaaaaatcgatgagcgccacctctttaaaaactcacttacgttgtcctttttcactttg aaaagttggaaggactgctgaggcccagtgcatatgcaatgtatagtgtctattatcaca ttaatctcaaagagattcgaatgacggtaagtgttctcatgaagcaggaggcccttgtcg tgggatggcatttggtctcaggcagcaccacactgggtgcgtctccagtcatctgtaaga 59- 98677.doc 200533758 gcttgctccagattctgatgcatacggctatattggtttatgtagtcagttgcattcatt a > 1451_s_at HG-U95AV2 gttgacttcaggaactgaaa catcagcacaaagaagcaatcatcaaataattctgaacac aaatttaatatttttttttctgaatgagaaacatgagggaaattgtggagttagcctcct gtggtaaaggaattgaagaaaatataacaccttacaccctttttcatcttgacattaaaa gttctggctaactttggaatccattagagaaaaatccttgtcaccagattcattacaatt caaatcgaagagttgtgaactgttatcccattgaaaagaccgagccttgtatgtatgtta tggatacataaaatgcacgcaagccattatctctccatgggaagctaagttataaaaata ggtgcttggtgtacaaaactttttatatcaaaaggctttgcacatttctatatgagtggg tttactggtaaattatgttattttttacaactaattttgtactctcagaatgtttgtcat atgcttcttgcaatgcata > 1457__at HG-U95Av2

caaacagcagctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcg gcaatacgttcaccgggacttggcagcaagaaatgtccttgttgagagtgaacaccaagt gaaaattggagacttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgt caaggatgaccgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaa attttatattgcctctgacgtctggtcttttggagtcactctgcatgagctgctgactta ctgtgattcagattctagtcccatggctttgttcctgaaaatgataggcccaacccatgg ccagatgacagtcacaagacttgtgaatacgttaaaagaaggaaaacgcctgccgtgccc acctaactgtccagatgaggtttatcagettatgagaaaatgetgggaattccaaccatc caatcggacaagctttcagaaccttattgaaggatttgaagca >14 61_at HG-U9 5AV2 tcagatgctgccagagagtgaggatgaggagagctatgacacagagtcagagttcacgga gttcacagaggacgagctgccctatgatgactgtgtgtttggaggccagcgtctgacgtt atgagtgcaaaggggctgaaagaacatggacttgtatatttgtacaaaaaaaaagtttta tttttctaaaaaaagaaaaaagaagaaaaaatttaaagggtgtacttatatccacactgc acactgcctagcccaaaacgtcttattgtggtaggatcagccctcattttgttgcttttg tgaactttttgtaggggacgagaaagatcattgaaattctgagaaaacttcttttaaacc tcacctttgtggggtttttggagaaggttatcaaaaatttcatggaaggaccacatttta tatttattgtgcttcgagtgactgaccccagtggtatcctgtgacatgtaacagccagga gtgttaagcgttcagtgatgtggggtgaaaagttactacctgtcaaggtttgtgttaccc tcctgtaaatggtgtacataatgtattgttggtaatt >1520_s_at HG-U95AV2 aettcaecatgcaatttgtgtcttcctaaagagagctgtacccagagagtcctgtgctga atgtggactcaatccctagggctggcagaaagggaacagaaaggtttttgagtacggcta tagcctggactttcctgttgtctacaccaatgcccaactgcctgccttagggtagtgcta agaggatctcctgtccatcagccaggacagtcagctctctcctttcagggccaatcccca gcccttttgttgagccaggcctctctcacctctcctactcacttaaagcccgcctgacag aaaccacggccacatttggttctaagaaaccctctgtcattcgctcccacattctgatga gcaaccgcttccctatttatttatttatttgtttgtttgttttgattcattggtctaatt tattcaaagggggcaagaagtagcagtgtctgtaaaagagcctagtttttaatagctatg gaatcaattcaatttggactggtgtgctctctttaaatcaagtcctttaattaagactga aaatatataagctcagattatttaaatgggaatatttataaatgagcaaatatcatactg ttcaatggttc >1561_at HG-U95Av2 gtgctgtttgcgcccttcggccgggcgggcgccccgggaccaggcggcggcagcgacctg cggcggcgggaggcagcgagggctgagccccgggacgcgcggaccggctggcccgaggag ccggccccggagacgcagttcaagcgccgcagctgccagatggagttcgaggagggcatg gtggaggggcgcgcgcgcggcgaggagctggccgccctgggcaagcaggcgagcttctcg ggcagcgtggaggtcatcgaggtgtcctgacccctccgctgccctcggccccgccgcccg cagccaggcccgttataaatgtatatta >1562_g_at HG-U95Av2 tatttaagctgttcattctggcaatgatttggcaacagtgcgggtggtcctcgagctcta tttttactgtctggtatttaaactgaaacatacgtttctaagcaatacgaggccaccttc 60- 98677.doc 200533758 agtcgcaagctgggtgccaggcctggggccctcccagttcccccgccccaggaaacactg ctgacctttgcaaaggctgccgagctttcgtg >1573_at HG-U95Av2 aaggacattgtatgcagggagcactgttcacatcatagataaagctgatttgtatattta ttatgacaatttctggcagatgtaggtaaagaggaaaaggatccttttcctaattcacac aaagactccttgtggactggctgtgcccctgatgcagcctgtggctggagtggccaaata ggagggagactgtggtaggggcagggaggcaacactgctgtccacatgacctccatttcc caaagtcctctgctccagcaactgcccttccaggtgggtgtgggacacctgggagaaggt ctccaagggagggtgcagccctcttgcccgcacccctccctgcttgcacacttccccatc tttgatccttctgagctccacctctggtggctcctcctaggaaaccagctcgtgggctgg gaatgggggagagaagggaaaagatccccaagaccccctggggtgggatctgagctccca cctcccttcccacctactgcactttcccccttcccgccttccaaaacctgcttccttcag t >1577一at HG-U95Av2 catggaattctatttgctgggctttttttttctctttctctcctttctttttcttcttcc ctccctatctaaccctcccatggcaccttcagactttgcttcccattgtggctcctatct gtgttttgaatggtgttgtatgcctttaaatctgtgatgatcctcatatggcccagtgtccaaacagcagctaaaatatgccgttcagatttgtaaggggatggactatttgggttctcg gcaatacgttcaccgggacttggcagcaagaaatgtccttgttgagagtgaacaccaagt gaaaattggagacttcggtttaaccaaagcaattgaaaccgataaggagtattacaccgt caaggatgaccgggacagccctgtgttttggtatgctccagaatgtttaatgcaatctaa attttatattgcctctgacgtctggtcttttggagtcactctgcatgagctgctgactta ctgtgattcagattctagtcccatggctttgttcctgaaaatgataggcccaacccatgg ccagatgacagtcacaagacttgtgaatacgttaaaagaaggaaaacgcctgccgtgccc acctaactgtccagatgaggtttatcagettatgagaaaatgetgggaattccaaccatc caatcggacaagctttcagaaccttattgaaggatttgaagca > 14 61_at HG-U9 5AV2 tcagatgctgccagagagtgaggatgaggagagctatgacacagagtcagagttcacgga gttcacagaggacgagctgccctatgatgactgtgtgtttggaggccagcgtctgacgtt atgagtgcaaaggggctgaaagaacatggacttgtatatttgtacaaaaaaaaagtttta tttttctaaaaaaagaaaaaagaagaaaaaatttaaagggtgtacttatatccacactgc acactgcctagcccaaaacgtcttattgtggtaggatcagccctcattttgttgcttttg tgaactttttgtaggggacgagaaagatcattgaaattctgagaaaacttcttttaaacc tcacctttgtggggtttttggagaaggttatcaaaaatttcatggaaggaccacatttta tatttattgtgcttcga gtgactgaccccagtggtatcctgtgacatgtaacagccagga gtgttaagcgttcagtgatgtggggtgaaaagttactacctgtcaaggtttgtgttaccc tcctgtaaatggtgtacataatgtattgttggtaatt > 1520_s_at HG-U95AV2 aettcaecatgcaatttgtgtcttcctaaagagagctgtacccagagagtcctgtgctga atgtggactcaatccctagggctggcagaaagggaacagaaaggtttttgagtacggcta tagcctggactttcctgttgtctacaccaatgcccaactgcctgccttagggtagtgcta agaggatctcctgtccatcagccaggacagtcagctctctcctttcagggccaatcccca gcccttttgttgagccaggcctctctcacctctcctactcacttaaagcccgcctgacag aaaccacggccacatttggttctaagaaaccctctgtcattcgctcccacattctgatga gcaaccgcttccctatttatttatttatttgtttgtttgttttgattcattggtctaatt tattcaaagggggcaagaagtagcagtgtctgtaaaagagcctagtttttaatagctatg gaatcaattcaatttggactggtgtgctctctttaaatcaagtcctttaattaagactga aaatatataagctcagattatttaaatgggaatatttataaatgagcaaatatcatactg ttcaatggttc > 1561_at HG-U95Av2 gtgctgtttgcgcccttcggccgggcgggcgccccgggaccaggcggcggcagcgacctg cggcggcgggaggcagcgagggctgagccccgggacgcgcggaccggctggcccgaggag ccggccccggagacgcagttcaagcgccgcagctgccagatggagttcgaggagggcatg gtggag gggcgcgcgcgcggcgaggagctggccgccctgggcaagcaggcgagcttctcg ggcagcgtggaggtcatcgaggtgtcctgacccctccgctgccctcggccccgccgcccg cagccaggcccgttataaatgtatatta > 1562_g_at HG-U95Av2 tatttaagctgttcattctggcaatgatttggcaacagtgcgggtggtcctcgagctcta tttttactgtctggtatttaaactgaaacatacgtttctaagcaatacgaggccaccttc 60- 98677.doc 200533758 agtcgcaagctgggtgccaggcctggggccctcccagttcccccgccccaggaaacactg ctgacctttgcaaaggctgccgagctttcgtg > 1573_at HG-U95Av2 aaggacattgtatgcagggagcactgttcacatcatagataaagctgatttgtatattta ttatgacaatttctggcagatgtaggtaaagaggaaaaggatccttttcctaattcacac aaagactccttgtggactggctgtgcccctgatgcagcctgtggctggagtggccaaata ggagggagactgtggtaggggcagggaggcaacactgctgtccacatgacctccatttcc caaagtcctctgctccagcaactgcccttccaggtgggtgtgggacacctgggagaaggt ctccaagggagggtgcagccctcttgcccgcacccctccctgcttgcacacttccccatc tttgatccttctgagctccacctctggtggctcctcctaggaaaccagctcgtgggctgg gaatgggggagagaagggaaaagatccccaagaccccctggggtgggatctgagctccca cctcccttcccacctactgcactttcccccttcccgccttccaaaacctgcttccttcag t > 1577 at HG-U a 95Av2 catggaattctatttgctgggctttttttttctctttctctctcttctttttctctcttcc ctccctatctaaccctcccatggcaccttcagactttgcttcccattgtggctcctatct gtgttttgaatggtgttgtatgcctttaaatgtgtgatgatcctcctcata

aagttgtgcttgtttacagcactactctgtgccagccacacaaacgtttacttatcttat gccacgg >158一at HG-U95Av2 gcaccaaaattacttttccaagagaaggagatgaaaacaccaaatagtattccagcagac attgtttttatcattaaagacaaagatcatccaaaatttaaaagggatggatcaaatata atttactgctaaaattagtttacgagaggagattgtgtggcgtgctcaattaatgtacca acactggatggaagaacatacctatgtcagtaaatgatattgtgaacccggaatgaggag aagaattattggatatgggctgccatttccaaaaaatcctgaccaacgtggtgaccttct aatagaatttgaggtgtccttcccagatactatatcttcttcatggaaagaagtactaga catctccgcctcatagaatgagacttgtaga >1591_s__at HG-U9 5AV2 ggacgtttccatcaggttccatcccgaaaatctctcggttccacgtccccctggggcttc tcctgacccagtccccgtgccccgcctccccgaaacaggctactctcctcggccccctcc atcgggctgaggaagcacagcagcatcttcaaacatgtacaaaatcgattggctttaaac a >159_at HG-U95Av2 gtactgttttccagttcatcgattttctattatggaaaactgtgttgccacagtagaact gtctgtgaacagagagacccttgtgggtccatgctaacaaagacaaaagtctgtctttcc tgaaccatgtggataactttacagaaatggactggagctcatctgcaaaaggcctcttgt aaagactggttttctgccaatgaccaaacagccaagattttcctcttgtgatttctttaa aagaatgactatataatttatttccactaaaaatattgtttctgcattcatttttatagc aacaacaattggtaaaactcactgtgatcaa >1633_g_at HG-U95Av2 tgttatcccaagtgctcttattctggtgagaagaaccttaattccataatttgggaagga atggaagatggacaccaccggacaccaccagacaataggatgggatggatggttttttgg gggatgggctaggggaaataaggcttgctgtttgttttcctggggcgctccctccaattt tgcagatttttgcaacctcctcctgagccgggattgtccaattactaaaatgtaaataat cacgtattgtggggaggggagttccaagtgtgccctccttttttttcctgcctggattat ttaaaaagccatgtgtggaaacccactatttaa >1637_at HG-U95AV2 tgacaaaagccagcatactttccctgcacccatctgctcaccagatctcaggcaggaaag cccctctctgttgaagtcaggggctatcttttggtatacttgtgtgaaagtggctggttg ggagcagagctaagtggcttcccattaacctgaggtctctttctttactctgggtcagac ctgaggttggggaaggcgactgagccatgctcagaatgtctggtcctggcttgggcctga gtagggcagagagggcctttcatggctgatcagagcttaccagccccaccccaccatggt agccttagggtgctgagtgcctgatactgcctgacaagtgcctgacacgcagcctagttc cttcctggcccctctctcactggctgggaaaccctagaccatgtcagataggacaacact -61 - 98677.doc 200533758 gctgggttttacatccagatagtaa >1652_at HG-U95Av2 caccacacaaacttagttcatatgcttttacttgggcaagggtgctttccttccaatacc ccagtagcttttattttagtaaagggaccctttcccctagcctagggtcccatattgggt caagctgcttacctgcctcagcccaggattttttattttgggggaggtaatgccctgttg ttaccccaaggcttct >1664_at HG-U95AV2 TIGRSequence >1669_at HG-U95AV2 tcagcccactacatagatagctttttttttttttttttttttttaataaggacacctctt tccaaacaggccatcaaatatgttcttatctcagacttacgttgttttaaaagtttggaa agatacacatcttttcatacccccccttaggaggttgggctttcatatcacctcagccaa ctgtggctcttaatttattgcataatgatatccacatcagccaactgtggctctttaatt tattgcataatgatattcacatcccctcagttgcagtgaattgtgagcaaaagatcttga aagcaaaaagcactaattagtttaaaatgtcacttttttggtttttattatacaaaaacc atgaagtactttttttatttgctaaatcagattgttcctttttagtgactcatgtttatgaagttgtgcttgtttacagcactactctgtgccagccacacaaacgtttacttatcttat gccacgg > 158 a at HG-U95Av2 gcaccaaaattacttttccaagagaaggagatgaaaacaccaaatagtattccagcagac attgtttttatcattaaagacaaagatcatccaaaatttaaaagggatggatcaaatata atttactgctaaaattagtttacgagaggagattgtgtggcgtgctcaattaatgtacca acactggatggaagaacatacctatgtcagtaaatgatattgtgaacccggaatgaggag aagaattattggatatgggctgccatttccaaaaaatcctgaccaacgtggtgaccttct aatagaatttgaggtgtccttcccagatactatatcttcttcatggaaagaagtactaga catctccgcctcatagaatgagacttgtaga > 1591_s__at HG-U9 5AV2 ggacgtttccatcaggttccatcccgaaaatctctcggttccacgtccccctggggcttc tcctgacccagtccccgtgccccgcctccccgaaacaggctactctcctcggccccctcc atcgggctgaggaagcacagcagcatcttcaaacatgtacaaaatcgattggctttaaac a > 159_at HG-U95Av2 gtactgttttccagttcatcgattttctattatggaaaactgtgttgccacagtagaact gtctgtgaacagagagacccttgtgggtccatgctaacaaagacaaaagtctgtctttcc tgaaccatgtggataactttacagaaatggactggagctcatctgcaaaaggcctcttgt aaagactggttttctgccaatgaccaaacagccaagattttcctcttgtgatttctttaa aagaatgactatataatttatttccactaaaaat attgtttctgcattcatttttatagc aacaacaattggtaaaactcactgtgatcaa > 1633_g_at HG-U95Av2 tgttatcccaagtgctcttattctggtgagaagaaccttaattccataatttgggaagga atggaagatggacaccaccggacaccaccagacaataggatgggatggatggttttttgg gggatgggctaggggaaataaggcttgctgtttgttttcctggggcgctccctccaattt tgcagatttttgcaacctcctcctgagccgggattgtccaattactaaaatgtaaataat cacgtattgtggggaggggagttccaagtgtgccctccttttttttcctgcctggattat ttaaaaagccatgtgtggaaacccactatttaa > 1637_at HG-U95AV2 tgacaaaagccagcatactttccctgcacccatctgctcaccagatctcaggcaggaaag cccctctctgttgaagtcaggggctatcttttggtatacttgtgtgaaagtggctggttg ggagcagagctaagtggcttcccattaacctgaggtctctttctttactctgggtcagac ctgaggttggggaaggcgactgagccatgctcagaatgtctggtcctggcttgggcctga gtagggcagagagggcctttcatggctgatcagagcttaccagccccaccccaccatggt agccttagggtgctgagtgcctgatactgcctgacaagtgcctgacacgcagcctagttc cttcctggcccctctctcactggctgggaaaccctagaccatgtcagataggacaacact -61 - 98677.doc 200533758 gctgggttttacatccagatagtaa > 1652_at HG-U95Av2 caccacacaaacttagttcatatgcttttacttgggcaagggtgctttccttcca atacc ccagtagcttttattttagtaaagggaccctttcccctagcctagggtcccatattgggt caagctgcttacctgcctcagcccaggattttttattttgggggaggtaatgccctgttg ttaccccaaggcttct > 1664_at HG-U95AV2 TIGRSequence > 1669_at HG-U95AV2 tcagcccactacatagatagctttttttttttttttttttttttaataaggacacctctt tccaaacaggccatcaaatatgttcttatctcagacttacgttgttttaaaagtttggaa agatacacatcttttcatacccccccttaggaggttgggctttcatatcacctcagccaa ctgtggctcttaatttattgcataatgatatccacatcagccaactgtggctctttaatt tattgcataatgatattcacatcccctcagttgcagtgaattgtgagcaaaagatcttga aagcaaaaagcactaattagtttaaaatgtcacttttttggtttttattatacaaaaacc atgaagtactttttttatttgctaaatcagattgttcctttttagtgactcatgtttatg

aagagagttgagtttaacaatcctagcttttaaaagaaactatttaatgtaaaatattct acatgtcattcagatattatgtatatcttctagcctttattctgtacttttaatgtacat atttctgtcttgcgtgatt >1674_at HG-U95Av2 gaagatggacttcatgcaagttggcagtggttctggtactaaaaattgtggttgtttttt ctgtttacgtaacctgcttagtattgacactctctaccaagagggtcttcctaagaagag tgctgtcattatttcctcttatcaacaacttgtgacatgagattttttaagggctttatg tgaactatgatattgtaatttttctaagcatattcaaaagggtgacaaaattacgtttat gtactaaatctaatcaggaaagtaaggcaggaaaagttgatggtattcattaggttttaa ctgaatggagcagttccttatataataacaattgtatagtagggataaaacactaacaat gtgtattcattttaaattgttctgtatttttaaattgccaagaaaaacaactttgtaaat ttggagatattttccaacagcttttcgtcttcagtgtcttaatgtggaagttaac >1717_s_at HG-U95AV2 atatatgtatctaaaccatatgaacatatattttttagaaactaagagaatgataggctt ttgttcttatgaacgaaaaagaggtagcactacaaacacaatattcaatccaaatttcag cattattgaaattgtaagtgaagtaaaacttaagatatttgagttaacctttaagaattt taaatattttggcattgtactaataccgggaacatgaagccaggtgtggtggtatgtacc tgtagtcccaggctgaggcaagagaattacttgagcccaggagtttgaatccatcctggg cagcatactgagaccctgcctttaaaaacnaacagnaccaaanccaaacaccagggacac atttctctgtcttttttgatcagtgtcctatacatcgaaggtgtgcatatatgttg >1737_s_at HG-U95Av2 aagagacatgtaccttgaccatcgtccttcctctcaagctagccagagggtgggagccta aggaagcgtggggtagcagatggagtaatggtcacgaggtccagacccactcccaaagct cagacttgccaggctccctttctcttcttccccaggtccttcctttaggtctggttgttg caccatctgcttggttggctggcagctgagagccctgctgtgggagagcgaagggggtca aaggaagacttgaagcacagagggctagggaggtggggtacatttctctgagcagtcagg gtgggaagaaagaatgcaagagtggactgaatgtgcctaatggagaagacccacgtgcta ggggatgaggggcttcctgggtcctgttccctaccccatttgtggtcacagccatgaagt caccgggatgaacctatccttccagtggctcgctccctgtagctctgcctccctctccat atctccttcccctacacctccctccccacacctccctactcccctgggcatcttctggct tgactggatggaagga >1761_at HG-U95Av2 gaggttgatccacagaggactgggacacaccacgagaatctcccagagtgtcattacagt ggaagacttcgagacgattgatgcaggatattacatttgcactgctcagaatcttcaagg acagaccacagtagctaccactgttgagttttcctgacttggaaaaggaaatgtaatgaa cttatggaaagcccatttgtgtacacagtcagctttggggttccttttattagtgctttg ccagaggctgatgtcaagcaccacaccccaaccccagcgtctcgtgagtccgacccagac atccaaactaaaaggaagtcatccagtctattcacagaagtgttaacttttctaacagaa 62- 98677.doc 200533758 agcatgattttgattgcttacctac >1778_g_at HG-U95Av2 cagtgggcagtcagaggcaagaagcagaggggaggagcaagggtgccagggagatgggga tgctggggtcaaagccagccccagggacattcgggaacagtctgagacaactgctgaagg gggccagggtcaagcccaggaaggccctgetcagecaggggaaccagaggcagagggaag ccgggcagcagaggagtagcttgaagtggccagaagggtcattcggggcgggagaccctg agcctgctgagaaatccttttagcgccagcaagccccacccagggccctgtcctgtgtct gccaccacctttgtctgatacttgtttccagggaagctgggggaactgccacatctgagg aactggaataa >1788」s_at HG-U95Av2aagagagttgagtttaacaatcctagcttttaaaagaaactatttaatgtaaaatattct acatgtcattcagatattatgtatatcttctagcctttattctgtacttttaatgtacat atttctgtcttgcgtgatt > 1674_at HG-U95Av2 gaagatggacttcatgcaagttggcagtggttctggtactaaaaattgtggttgtttttt ctgtttacgtaacctgcttagtattgacactctctaccaagagggtcttcctaagaagag tgctgtcattatttcctcttatcaacaacttgtgacatgagattttttaagggctttatg tgaactatgatattgtaatttttctaagcatattcaaaagggtgacaaaattacgtttat gtactaaatctaatcaggaaagtaaggcaggaaaagttgatggtattcattaggttttaa ctgaatggagcagttccttatataataacaattgtatagtagggataaaacactaacaat gtgtattcattttaaattgttctgtatttttaaattgccaagaaaaacaactttgtaaat ttggagatattttccaacagcttttcgtcttcagtgtcttaatgtggaagttaac > 1717_s_at HG-U95AV2 atatatgtatctaaaccatatgaacatatattttttagaaactaagagaatgataggctt ttgttcttatgaacgaaaaagaggtagcactacaaacacaatattcaatccaaatttcag cattattgaaattgtaagtgaagtaaaacttaagatatttgagttaacctttaagaattt taaatattttggcattgtactaataccgggaacatgaagccaggtgtggtggtatgtacc tgtagtcccaggctgaggcaagagaattacttgagcccaggagtttgaatccatcctggg cagcatactgagaccctgccttta aaaacnaacagnaccaaanccaaacaccagggacac atttctctgtcttttttgatcagtgtcctatacatcgaaggtgtgcatatatgttg > 1737_s_at HG-U95Av2 aagagacatgtaccttgaccatcgtccttcctctcaagctagccagagggtgggagccta aggaagcgtggggtagcagatggagtaatggtcacgaggtccagacccactcccaaagct cagacttgccaggctccctttctcttcttccccaggtccttcctttaggtctggttgttg caccatctgcttggttggctggcagctgagagccctgctgtgggagagcgaagggggtca aaggaagacttgaagcacagagggctagggaggtggggtacatttctctgagcagtcagg gtgggaagaaagaatgcaagagtggactgaatgtgcctaatggagaagacccacgtgcta ggggatgaggggcttcctgggtcctgttccctaccccatttgtggtcacagccatgaagt caccgggatgaacctatccttccagtggctcgctccctgtagctctgcctccctctccat atctccttcccctacacctccctccccacacctccctactcccctgggcatcttctggct tgactggatggaagga > 1761_at HG-U95Av2 gaggttgatccacagaggactgggacacaccacgagaatctcccagagtgtcattacagt ggaagacttcgagacgattgatgcaggatattacatttgcactgctcagaatcttcaagg acagaccacagtagctaccactgttgagttttcctgacttggaaaaggaaatgtaatgaa cttatggaaagcccatttgtgtacacagtcagctttggggttccttttattagtgctttg ccagaggctgatgtcaagcaccacaccccaaccccagcgtctcgtgagtc cgacccagac atccaaactaaaaggaagtcatccagtctattcacagaagtgttaacttttctaacagaa 62- 98677.doc 200533758 agcatgattttgattgcttacctac > 1778_g_at HG-U95Av2 cagtgggcagtcagaggcaagaagcagaggggaggagcaagggtgccagggagatgggga tgctggggtcaaagccagccccagggacattcgggaacagtctgagacaactgctgaagg gggccagggtcaagcccaggaaggccctgetcagecaggggaaccagaggcagagggaag ccgggcagcagaggagtagcttgaagtggccagaagggtcattcggggcgggagaccctg agcctgctgagaaatccttttagcgccagcaagccccacccagggccctgtcctgtgtct gccaccacctttgtctgatacttgtttccagggaagctgggggaactgccacatctgagg aactggaataa > 1788 s_at HG-U95Av2 "

agtgatgaaacccacagateetagcaaatgtgcccaaccagctttactaaagggggagga agggagggcaaagggatgagaagacaagtttcccagaagtgcctggttctgtgtacttgt ccctttgttgtcgtcgttgtagttaaaggaatttcattttttaaaagaaatcttcgaagg tgtggttttcatttctcagtcaccaacagatgaataattatgcttaataataaagtattt attaagactttcttcagagtatgaaagtacaaaaagtctagttacagtggatttagaata tatttatgttgatgtcaaacagctgagcaccgtagcatgcagatgtcaaggcagttagga agtaaatcggtgtcttgtagatatgtgcaaggtagcatgatgagcaacttgagtttgttg ccactgagaagcaggcg >1798_at HG-U95AV2 tagtttatgtatcaccagactgggttattgccaagttatatatcaccaaaagctgtatga ctggatgttctggttacctggtttacaaaattatcagagtagtaaaactttgatatatat gaggatattaaaactacactaagtatcatttgattcgattcagaaagtactttgatatct ctcagtgcttcagtgctatcattgtgagcaattgtctttatatacggtactgtagccata ctaggcctgtctgtggcattctctagatgtttcttttttacacaataaattccttatatc agettga >1845_at HG-U95Av2 agacattgctctatgtctgccttcgaccacagcaagccatcatcctccattgctcccggg gactcaagaggaatctgtttctctgctgtcaacttcccatctggctcagcatagggtcac tttgccattatgcaaatggagataaaagcaattctggctgtccaggagctaatctgaccg ttctattgtgtggatgaccacataagaaggcaattttagtgtattaatcatagattatta taaactataaacttaagggcaaggagtttattacaatgtatctttattaaaacaaaaggg tgtatagtgttcacaaactgtgaaaatagtg >18 67__at HG-U9 5Av2 taacaccctatgcccattgtcctgatctgaaaattcttggaaattgttccatgtgattaa catggaactgcctctacttaatcattctgaatgattaaatcgtttcattttctaaatgtg ttataatgtgtttagccctttcttgttgctgtatgtttagatgctttccaatcttttgtt actactaataatg >1868_g_at HG-U95Av2 atttgacctgctcaaacgtatcttgaagatggacagaaaagctgtggagacccacctgct caggaaccctcaccttgtttcggactatagagtgctgatggcagagattggtgaggattt ggataaatctgatgtgtcctcattaattttcctcatgaaggattacatgggccgaggcaa gataagcaaggagaagatttcttgggaccttgtggttgagttggagaaactaaatctggt tgccccagatcaactggatttattagaaaaatgcctaaagaacatccacagaatagacct gaagacaaaaatccagaagtacaagcagtctgttcaaggagcagggacaagttacaggaa tgttctccaagcagcaatccaaaagagtctcaaggatccttcaaataa >1876_at HG-U95AV2 TIGRSequence >1877—g_at HG-U95AV2 TIGRSequence >1897_at HG-U95Av2 ggaaccacagatttgtgcccattcctaatattttgttctgcaaattaatgtataatttga ggtgaaattcagttataaagtcaaggacgaatttgcacagtgatatatttctatgtgtat -63 - 98677.doc 200533758 gcaagtacaagtatataatatgtcacctggcacattcattttctcagttgaagaagagaa aatttgaaaatgtccttatgcttttagagttgcaacttaagtatatttggtagggtgagt gtttccactcaaaatatgtcaacttaaaaaaaaataggccctttcataaaaaccaaactg tagcaagatgcaaatgcatggcaaatctgtcggtctccagttggttatctgaatagtgtc accaattccaccaagacagtgetgagattggaaagggcactcatttggattgccttactt ctcttgccttaaatatatcccatatatttaatatgtcaaaaagggcttgaggtgaatttc attaaatggaataatatgatgccactttgcagctaaaataagc >1951_atHG-U95Av2 tcaaggccacaaccatgatgatccgaccagcagatttctaaacatcccagtccacctgag gaactgtctcgaactattttcaaagacttaagcccagtgcactgaaagtcacggctgcgc actgtgtcctcttccaccacagagggcgtgtgctcggtgctgacgggacccacatgctcc agattagagcctgtaaactttatcacttaaacttgcatcacttaacggaccaaagcaaga ccctaaacatccataattgtgattagacagaacacctatgcaaagatgaacccgaggctg agaatcagactgacagtttacagacgctgctgtcacaaccaagaatgttatgtgcaagtt tatcagtaaataactggaaaacagaacacttatgttatacaatacagatcatettggaac tgcattcttctgagcactgtttatacactgt >1968_g__at HG-U95Av2agtgatgaaacccacagateetagcaaatgtgcccaaccagctttactaaagggggagga agggagggcaaagggatgagaagacaagtttcccagaagtgcctggttctgtgtacttgt ccctttgttgtcgtcgttgtagttaaaggaatttcattttttaaaagaaatcttcgaagg tgtggttttcatttctcagtcaccaacagatgaataattatgcttaataataaagtattt attaagactttcttcagagtatgaaagtacaaaaagtctagttacagtggatttagaata tatttatgttgatgtcaaacagctgagcaccgtagcatgcagatgtcaaggcagttagga agtaaatcggtgtcttgtagatatgtgcaaggtagcatgatgagcaacttgagtttgttg ccactgagaagcaggcg > 1798_at HG-U95AV2 tagtttatgtatcaccagactgggttattgccaagttatatatcaccaaaagctgtatga ctggatgttctggttacctggtttacaaaattatcagagtagtaaaactttgatatatat gaggatattaaaactacactaagtatcatttgattcgattcagaaagtactttgatatct ctcagtgcttcagtgctatcattgtgagcaattgtctttatatacggtactgtagccata ctaggcctgtctgtggcattctctagatgtttcttttttacacaataaattccttatatc agettga > 1845_at HG-U95Av2 agacattgctctatgtctgccttcgaccacagcaagccatcatcctccattgctcccggg gactcaagaggaatctgtttctctgctgtcaacttcccatctggctcagcatagggtcac tttgccattatgcaaatggagataaaagcaattctggctgtccaggagctaatctgaccg ttctattgtgtggat gaccacataagaaggcaattttagtgtattaatcatagattatta taaactataaacttaagggcaaggagtttattacaatgtatctttattaaaacaaaaggg tgtatagtgttcacaaactgtgaaaatagtg > 18 67__at HG-U9 5Av2 taacaccctatgcccattgtcctgatctgaaaattcttggaaattgttccatgtgattaa catggaactgcctctacttaatcattctgaatgattaaatcgtttcattttctaaatgtg ttataatgtgtttagccctttcttgttgctgtatgtttagatgctttccaatcttttgtt actactaataatg > 1868_g_at HG-U95Av2 atttgacctgctcaaacgtatcttgaagatggacagaaaagctgtggagacccacctgct caggaaccctcaccttgtttcggactatagagtgctgatggcagagattggtgaggattt ggataaatctgatgtgtcctcattaattttcctcatgaaggattacatgggccgaggcaa gataagcaaggagaagatttcttgggaccttgtggttgagttggagaaactaaatctggt tgccccagatcaactggatttattagaaaaatgcctaaagaacatccacagaatagacct gaagacaaaaatccagaagtacaagcagtctgttcaaggagcagggacaagttacaggaa tgttctccaagcagcaatccaaaagagtctcaaggatccttcaaataa > 1876_at HG-U95AV2 TIGRSequence > 1877-g_at HG-U95AV2 TIGRSequence > 1897_at HG-U95Av2 ggaaccacagatttgtgcccattcctaatattttgttctgcaaattaatgtataatttga ggtgaaattcagttataaagtcaaggacgaatttgcacagtga tatatttctatgtgtat -63 - 98677.doc 200533758 gcaagtacaagtatataatatgtcacctggcacattcattttctcagttgaagaagagaa aatttgaaaatgtccttatgcttttagagttgcaacttaagtatatttggtagggtgagt gtttccactcaaaatatgtcaacttaaaaaaaaataggccctttcataaaaaccaaactg tagcaagatgcaaatgcatggcaaatctgtcggtctccagttggttatctgaatagtgtc accaattccaccaagacagtgetgagattggaaagggcactcatttggattgccttactt ctcttgccttaaatatatcccatatatttaatatgtcaaaaagggcttgaggtgaatttc attaaatggaataatatgatgccactttgcagctaaaataagc > 1951_atHG-U95Av2 tcaaggccacaaccatgatgatccgaccagcagatttctaaacatcccagtccacctgag gaactgtctcgaactattttcaaagacttaagcccagtgcactgaaagtcacggctgcgc actgtgtcctcttccaccacagagggcgtgtgctcggtgctgacgggacccacatgctcc agattagagcctgtaaactttatcacttaaacttgcatcacttaacggaccaaagcaaga ccctaaacatccataattgtgattagacagaacacctatgcaaagatgaacccgaggctg agaatcagactgacagtttacagacgctgctgtcacaaccaagaatgttatgtgcaagtt tatcagtaaataactggaaaacagaacacttatgttatacaatacagatcatettggaac tgcattcttctgagcactgtttatacactgt > 1968_g__at HG-U95Av2

ctatggattaagccggtcccaacctgtcatgaaagttgcagtgaagatgctaaaacccac ggccagatccagtgaaaaacaagctctcatgtctgaactgaagataatgactcacctggg gccacatttgaacattgtaaacttgctgggagcctgcaccaagtcaggccccatttacat catcacagagtattgcttctatggagatttggtcaactatttgcataagaatagggatag cttcctgagccaccacccagagaagccaaagaaagagctggatatctttggattgaaccc tgctgatgaaagcacacggagctatgttattttatcttttgaaaacaatggtgactacat ggacatgaagcaggctgatactacacagtatgtccccatgctagaaaggaaagaggtttc taaatattccgacatccagagatcactctatgatcgtccag >1987_at HG-U95Av2 agaggaacctgagtcatgctcaggcccaagccctgttggcaggcagaccactgctttctg gccttccgtgactatctgaaaaaaatcgtgaatggctagagctactcttcacttgctgaa cattttcaaaaagaattgacacttgctgaacatttcttttcaattcagaacttctgatgg attaaattgccttcttcctcgaaaaccctgggacccttccagatgggactaactggggaa agtggacaagttacaaacaaagaaactcaaaggaaagtcattggcactgatctctaagat gctatcacatgtgattggtggttga >2002_s_at HG-U95Av2 ctacagataccacaacctggatcaggtccaagcaaaacgtccagagtgctacaaaatgtt gcgttctcagtccaaaaagaagtggaaaagaatctgaagtcatgcttggacaatgttaat gttgtgtccgtagacactgccagaacactattcaaccaagtgatggaaaaggagtttgaa gacggcatcattaactggggaagaattgtaaccatatttgcatttgaaggtattctcatc aagaaacttctacgacagcaaattgccccggatgtggatacctataaggagatttcatat tttgttgcggagttcataatgaa >2014_s_at HG-U95Av2 ccatccttcgatttccctatgattcatggggaactccatttcagcagctcaaacaggtgg tagaggagccatcgccacaactcccagcagacaagttctctgcagagtttgttgacttta cctcacagtgcttaaagaagaattccaaagaacggcctacatacccagagctaatgcaac atccatttttcdccctacatgaatccasaggaacagatgtggcatcttttgtaaaactga ttcttggagactaaaaagcagtggacttaatcggttgaccctactgtggattggtgggtt tcggggtgaagcaagttcactacagcatcaatagaaagtcatctttgagataatttaacc ctgcctctcagagggttttctctcccaattttctttttactccccctcttaagggggcct tggaatetatagtata >2018_at HG-U95AV2 tcdgcttgagtgctgtttdcacttgcaaaagagatccctgcccacatcaggtggactgtt tcctctctcgccccacggagaaaaccatcttcatcatcttcatgctggtggtgtccttgg tgtccctggccttgaatatcattgaactcttctatgttttcttcaagggcgttaaggatc gggttaagggaaagagcgacccttaccatgcgaccagtggtgcgctgagccctgccaaag actgtgggtctcaaaaatatgcttatttcaatggctgctcctcaccaaccgctcccctct cgcctatgtctcctcctgggtacaagctggttactggcgacagaaacaattcttcttgcc 64- 98677.doc 200533758 gcaattacaacaagcaagcaagtgagcaaaactgggctaattacagtgcagaacaaaatc gaatggggcaggcgggaagcaccatctctaactcccatgcacagccttttgatttccccg atgataaccagaattctaaaaaactagctgctggacatgaattacagccactagccattg tggaccagcgaccttcaagcagagccagcagtcgtgccagcagcagacctcggcc >2024_s_at HG-U95AV2 agtttgctggatttcctgaagagcgatgaaggtggcaaagtgctgcttccaaagctcatt gacttttctgctcagattgcagagggaatggcatacatcgagcggaagaactacattcac cgggacctgcgagcagctaatgttctggtctccgagtcactaatgtgcaaaattgcagat tttggccttgctagagtaattgaagataatgagtacacagcaagggaaggtgctaagttc cctattaagtggacggctccagaagcaatcaactttggatgtttcactattaagtctgat gtgtggtcctttggaatcctcctatacgaaattgtcacctatgggaaaattccctaccca gggagaactaatgccgacgtgatgaccgccctgtcccagggctacaggatgccccgtgtg gagaactgcccagatgagctctatgacattatgaaaatgtgctggaaagaaaaggcagaa gagagaccaacgtttgactacttacagagcgtcctggatgatttctacacagccacggaa gggcaatacc >2036_s_at HG-U95Av2ctatggattaagccggtcccaacctgtcatgaaagttgcagtgaagatgctaaaacccac ggccagatccagtgaaaaacaagctctcatgtctgaactgaagataatgactcacctggg gccacatttgaacattgtaaacttgctgggagcctgcaccaagtcaggccccatttacat catcacagagtattgcttctatggagatttggtcaactatttgcataagaatagggatag cttcctgagccaccacccagagaagccaaagaaagagctggatatctttggattgaaccc tgctgatgaaagcacacggagctatgttattttatcttttgaaaacaatggtgactacat ggacatgaagcaggctgatactacacagtatgtccccatgctagaaaggaaagaggtttc taaatattccgacatccagagatcactctatgatcgtccag > 1987_at HG-U95Av2 agaggaacctgagtcatgctcaggcccaagccctgttggcaggcagaccactgctttctg gccttccgtgactatctgaaaaaaatcgtgaatggctagagctactcttcacttgctgaa cattttcaaaaagaattgacacttgctgaacatttcttttcaattcagaacttctgatgg attaaattgccttcttcctcgaaaaccctgggacccttccagatgggactaactggggaa agtggacaagttacaaacaaagaaactcaaaggaaagtcattggcactgatctctaagat gctatcacatgtgattggtggttga > 2002_s_at HG-U95Av2 ctacagataccacaacctggatcaggtccaagcaaaacgtccagagtgctacaaaatgtt gcgttctcagtccaaaaagaagtggaaaagaatctgaagtcatgcttggacaatgttaat gttgtgtccgtagacactgccagaacactatt caaccaagtgatggaaaaggagtttgaa gacggcatcattaactggggaagaattgtaaccatatttgcatttgaaggtattctcatc aagaaacttctacgacagcaaattgccccggatgtggatacctataaggagatttcatat tttgttgcggagttcataatgaa > 2014_s_at HG-U95Av2 ccatccttcgatttccctatgattcatggggaactccatttcagcagctcaaacaggtgg tagaggagccatcgccacaactcccagcagacaagttctctgcagagtttgttgacttta cctcacagtgcttaaagaagaattccaaagaacggcctacatacccagagctaatgcaac atccatttttcdccctacatgaatccasaggaacagatgtggcatcttttgtaaaactga ttcttggagactaaaaagcagtggacttaatcggttgaccctactgtggattggtgggtt tcggggtgaagcaagttcactacagcatcaatagaaagtcatctttgagataatttaacc ctgcctctcagagggttttctctcccaattttctttttactccccctcttaagggggcct tggaatetatagtata > 2018_at HG-U95AV2 tcdgcttgagtgctgtttdcacttgcaaaagagatccctgcccacatcaggtggactgtt tcctctctcgccccacggagaaaaccatcttcatcatcttcatgctggtggtgtccttgg tgtccctggccttgaatatcattgaactcttctatgttttcttcaagggcgttaaggatc gggttaagggaaagagcgacccttaccatgcgaccagtggtgcgctgagccctgccaaag actgtgggtctcaaaaatatgcttatttcaatggctgctcctcaccaaccgctcccctct cgcctatgtctcctcctgggtacaagctgg ttactggcgacagaaacaattcttcttgcc 64- 98677.doc 200533758 gcaattacaacaagcaagcaagtgagcaaaactgggctaattacagtgcagaacaaaatc gaatggggcaggcgggaagcaccatctctaactcccatgcacagccttttgatttccccg atgataaccagaattctaaaaaactagctgctggacatgaattacagccactagccattg tggaccagcgaccttcaagcagagccagcagtcgtgccagcagcagacctcggcc > 2024_s_at HG-U95AV2 agtttgctggatttcctgaagagcgatgaaggtggcaaagtgctgcttccaaagctcatt gacttttctgctcagattgcagagggaatggcatacatcgagcggaagaactacattcac cgggacctgcgagcagctaatgttctggtctccgagtcactaatgtgcaaaattgcagat tttggccttgctagagtaattgaagataatgagtacacagcaagggaaggtgctaagttc cctattaagtggacggctccagaagcaatcaactttggatgtttcactattaagtctgat gtgtggtcctttggaatcctcctatacgaaattgtcacctatgggaaaattccctaccca gggagaactaatgccgacgtgatgaccgccctgtcccagggctacaggatgccccgtgtg gagaactgcccagatgagctctatgacattatgaaaatgtgctggaaagaaaaggcagaa gagagaccaacgtttgactacttacagagcgtcctggatgatttctacacagccacggaa gggcaatacc > 2036_s_at HG-U95Av2

gagetgggacacttaacagatgcaatgtgctactgattgtttcattgcgaatctttttta gcataaaattttctactctttttgttttttgtgttttgttctttaaagtcaggtccaatt tgtaaaaacageattgetttgtaaattagggcccaattaataatcageaagaatttgate gttcagttccacttggaggccttcatcctcgggtgtgctatggatggcttct >2049_s_at HG-U95Av2 aagccctggacgatctgcacaagatgaaccacgtgacaccccccaacgtgtccctgggcg ctaccggggggcccccggctgggcccgggggcgtctacgccggcccggagccacctcccg tttacaccaacctcagcagctactccccagcctctgcgtcctcgggaggcgccggggctg ccgtcgggaccgggagctcgtacccgacgaccaccatcagctacctcccacacgcgccgc ccttcgccggtggccacccggcgcagctgggcttgggccgcggcgcctccaccttcaagg aggaaccgcagaccgtgccggaggcgcgcagccgggacgccacgccgccggtgtccccca tcaacatggaagaccaagagcgcatcaaagtggagcgcaagcggctgcggaaccggctgg cggccaccaagtgccggaagcggaagctggagcgcatcgcgcgcctggaggacaaggtga agacgctcaaggccgagaacgcggggctgtcgagtaccgccggcctcctccgggagcagg tggcccagctcaaacagaaggtcatgacccacgtcagcaacggctgtcagctgctgcttg gg >204_at HG-U95AV2 agatcttaaccagtttctatcccttacctgcttttctcttctcttctcctgctccgttcc tcatccacccctccccatctggaccataatagggacaccaaaacaaacccaaattggtaa aaagaataatcaaaaagaagacattatccggttaagagtctgtgctggttgccacnnaag agagaacagttgtccaggatgctggctggtggaacaacctgctggcccgaaacaaggctg ccaggtgtggaacagcccatgc >205_g_at HG-U95Av2 acagcccatgctgactggggacatacacttgcatctttgttgaaagcagaagaagacaga ccctttccccaccttccttacctcctcttcccccattaaggcagctcatccaagcttgta tttaactgaataaatgagtagacattgtggacctcacaagattatttaattcttaagatg tgtagaccttgatggtaggtgtgacatgttagtttttcttacttgcatttatttaagaca cactgttacagagatactgttgtcaccttctggggcacggtctttggggagaggggagtg catttagacttatgtggaacctgtacaaattgtgatgtggctacatagaaa >2073_s_at HG-U95Av2 ccacagctgtgctggaccgtgagtccccatttgtcgacaacagcgtgtacactgctctct tcctggcaattgacagtggcaaccctcccgctacgggcactgggactttgctgataaccc tggaggacgtgaatgacaatgccccgttcatttaccccacagtagctgaagtctgtgatg atgccaaaaacctcagtgtagtcattttgggagcatcagataaggatcttcacccgaata cagatcctttcaaatttgaaatccacaaacaagctgttcctgataaagtctggaagatct ccaagatcaacaatacacacgccctggtaagccttcttcaaaatctgaacaaagcaaact acaacctgcccatcatggtgacagattcagggaaaccacccatgacgaatatcacagatc tcagggtacaagtgtgctcctgcaggaattccaaagtggactgcaacgcggcgggggccc tgcgcttcagcctgccctcagtcctgctcctcagcctcttcagcttagcttgtctgtgag 65- 98677.doc 200533758 aactcctgacgtctgaagct >215_g_at HG-U95Av2 ggcgcccgtgggactctacacggcccatgtgggctacagcatgtaccacctgacatagag ggtcccaggtccccacctgtgggccagccgattcctccagccctggtgctgtacccccga cgtgctcccctgctcggcaccgccagccgccttccctttaaccctcacactgctccagtt tcacctctttgctccctgagttcactctccgaagtctgatccctgccaaaaagtggctgg aagagtcccttagtactcttctagcatt >231_at HG-U95Av2 acctcaecattgtgaagcacctactatgtgctgggtgcctcccacacttgctggggctea cggggcctccaacccatttaatcaccatgggaaactgttgtgggcgctgcttccaggata aggagactgaggcttagagagaggaggcagccccctccacaccagtggcctcgtggttat aagcaaggctgggtaatgtgaaggcccaagagcagagtctgggcctctgactctgagtcc actgctccatttataaccccagcctgacctgagactgtcgcagaggctgtctggggcctt tatcaaaaaaagactcagccaagacaaggaggtagagaggggactgggggactgggagtc agagccctggctgggttcaggtcccacgtctggccagcgactgccttctcctctctgggc ctttgtttccttgttggtcagaggagtgattgaacctgctcatctccaaggatcctctcc agagetgggacacttaacagatgcaatgtgctactgattgtttcattgcgaatctttttta gcataaaattttctactctttttgttttttgtgttttgttctttaaagtcaggtccaatt tgtaaaaacageattgetttgtaaattagggcccaattaataatcageaagaatttgate gttcagttccacttggaggccttcatcctcgggtgtgctatggatggcttct > 2049_s_at HG-U95Av2 aagccctggacgatctgcacaagatgaaccacgtgacaccccccaacgtgtccctgggcg ctaccggggggcccccggctgggcccgggggcgtctacgccggcccggagccacctcccg tttacaccaacctcagcagctactccccagcctctgcgtcctcgggaggcgccggggctg ccgtcgggaccgggagctcgtacccgacgaccaccatcagctacctcccacacgcgccgc ccttcgccggtggccacccggcgcagctgggcttgggccgcggcgcctccaccttcaagg aggaaccgcagaccgtgccggaggcgcgcagccgggacgccacgccgccggtgtccccca tcaacatggaagaccaagagcgcatcaaagtggagcgcaagcggctgcggaaccggctgg cggccaccaagtgccggaagcggaagctggagcgcatcgcgcgcctggaggacaaggtga agacgctcaaggccgagaacgcggggctgtcgagtaccgccggcctcctccgggagcagg tggcccagctcaaacagaaggtcatgacccacgtcagcaacggctgtcagctgctgcttg gg > 204_at HG-U95AV2 agatcttaaccagtttctatcccttacctgcttttctcttctcttctcctgctccgttcc tcatccacccctccccatctggaccataatagggacaccaaaaca aacccaaattggtaa aaagaataatcaaaaagaagacattatccggttaagagtctgtgctggttgccacnnaag agagaacagttgtccaggatgctggctggtggaacaacctgctggcccgaaacaaggctg ccaggtgtggaacagcccatgc > 205_g_at HG-U95Av2 acagcccatgctgactggggacatacacttgcatctttgttgaaagcagaagaagacaga ccctttccccaccttccttacctcctcttcccccattaaggcagctcatccaagcttgta tttaactgaataaatgagtagacattgtggacctcacaagattatttaattcttaagatg tgtagaccttgatggtaggtgtgacatgttagtttttcttacttgcatttatttaagaca cactgttacagagatactgttgtcaccttctggggcacggtctttggggagaggggagtg catttagacttatgtggaacctgtacaaattgtgatgtggctacatagaaa > 2073_s_at HG-U95Av2 ccacagctgtgctggaccgtgagtccccatttgtcgacaacagcgtgtacactgctctct tcctggcaattgacagtggcaaccctcccgctacgggcactgggactttgctgataaccc tggaggacgtgaatgacaatgccccgttcatttaccccacagtagctgaagtctgtgatg atgccaaaaacctcagtgtagtcattttgggagcatcagataaggatcttcacccgaata cagatcctttcaaatttgaaatccacaaacaagctgttcctgataaagtctggaagatct ccaagatcaacaatacacacgccctggtaagccttcttcaaaatctgaacaaagcaaact acaacctgcccatcatggtgacagattcagggaaaccacccatgacgaatatcacagatc tcagggta caagtgtgctcctgcaggaattccaaagtggactgcaacgcggcgggggccc tgcgcttcagcctgccctcagtcctgctcctcagcctcttcagcttagcttgtctgtgag 65- 98677.doc 200533758 aactcctgacgtctgaagct > 215_g_at HG-U95Av2 ggcgcccgtgggactctacacggcccatgtgggctacagcatgtaccacctgacatagag ggtcccaggtccccacctgtgggccagccgattcctccagccctggtgctgtacccccga cgtgctcccctgctcggcaccgccagccgccttccctttaaccctcacactgctccagtt tcacctctttgctccctgagttcactctccgaagtctgatccctgccaaaaagtggctgg aagagtcccttagtactcttctagcatt > 231_at HG-U95Av2 acctcaecattgtgaagcacctactatgtgctgggtgcctcccacacttgctggggctea cggggcctccaacccatttaatcaccatgggaaactgttgtgggcgctgcttccaggata aggagactgaggcttagagagaggaggcagccccctccacaccagtggcctcgtggttat aagcaaggctgggtaatgtgaaggcccaagagcagagtctgggcctctgactctgagtcc actgctccatttataaccccagcctgacctgagactgtcgcagaggctgtctggggcctt tatcaaaaaaagactcagccaagacaaggaggtagagaggggactgggggactgggagtc agagccctggctgggttcaggtcccacgtctggccagcgactgccttctcctctctgggc ctttgtttccttgttggtcagaggagtgattgaacctgctcatctccaaggatcctctcc a

>257_at HG-U95AV2 tagcaacagtcatttctgaaaatatgttggatagaaagtcactctttggcaaaagtgtta gaatttgcttttgtgccatctattccttttatggcatctatcttgaaagtaatcttgtat tggagattgaaagatgctgtaatttagaaattaacatgatatcttaaattacctttatga aatatagttttgtataatagcatagattttccttcaaaaaatgaacatttatatatctac aaaaatatggagaagagcaatttgaaagcctactttctgaagaaaatggtgggatttttt tttatcatgattaaatatcaaaaaattgccctatgaaaactttaaatctctaaaacattt gaaatactaccdtatttgtgatttattgagaataaaaatccattttgaaatgtaaaattt ttatgatctgattcagttttaagaa >2 65_s__at HG-U95Av2 atgtctaatagttattccctatttgttttcttctgtatgttagggtgctctggaagagag gaatgcctgtgtgagcaagcatttatgtttatttataagcagatttaacaattccaaagg aatctccagttttcagttgatcactggcaatgaaaaattctcagtcagtaattgccaaag ctgctctagccttgaggagtgtgagaatcaaaactctcctacacttccattaacttagca tgtgttgaaaaaaaaagtttcagagaagttctggctgaacactggcaacgacaaagccaa cagtcaaaacagagatgtgataaggatcagaacagcagaggttcttttaaaggggcagaa aaactctgggaaataagagagaacaactactgtgatcaggctatgtatggaatacagtgt tattttctttgaaattgtttaagtgttgtaaatatttatgtaaactgcattagaaattag ctgtgtgaaataccagtgtggtttgtgtttgagttttattgagaattttaaattataact taaaatattttataatttttaaagtatatatttatttaagcttatgtcagacctatttga cataacactataaa >286_at HG-U95Av2 tcgccaggcaggagtttctctcggtgactactatcgctgtcatgtctggtcgtggcaagc aaggaggcaaggcccgcgccaaggccaagtcgcgctcgtcccgcgctggccttcagttcc cggtagggcgagtgcatcgcttgctgcgcaaaggcaactacgcggagcgagtgggggccg gcgcgcccgtctacatggctgcggtcctcgagtatctgaccgccgagatcctggagctgg cgggcaacgcggctcgggacaacaagaagacgcgcatcatccctcgtcacctccagctgg ccatccgcaacgacgaggaactgaacaagctgctgggcaaagtcaccatcgcccagggcg gcgtcttgcctaacatccaggccgtactgctccctaagaagacggagagtcaccacaagg caaagggcaagtgaggctgacgtccggcccaagtgggcccagcccggcccgcgtctcgaa ggggcacctgtgaactcaaaaggctctt >287__at HG-U9 5Av2 gttaacacaaaatccatgggcagcatgatggcaggtcctctgttgcaaactcagttccaa agtcacaggaagaaagcagaaagttcaacttccaaagggttaggactctccactcaatgt cttaggtcaggagttgtgtctaggctggaagagccaaagaaatattccattttcctttcc ttgtggttgaaaccacagtcagtggagagatgtttggaacacagtcagtggagctggtgg taccaggtttagcattattggatgtcaaaagcattttttttgtcatgtagctgttttaag aaatctggcccagggtgtttgcagctgtgagaagtcactcacactggccacaaggacgct 66- 98677.doc 200533758 ggctactgtctattaaaattctgatgtttctgtgaaattctcagagtgtttaatt >31472_s_at HG-U95Av2 gacaagttttggtggcacgcagcctggggactctgcctcgtgccgctgagcctggcgcag atcgatttgaatatnnnnnnnnnnnnnnnnnnnnnattccacgtggagaaaaatggtcgc tacagcatctctcggacggaggccgctgacctctgcaaggctttcaatagcaccttgccc acaatggcccagatggagaaagctctgagcatcggatttgagacctgcagtttgcattgc agtcaacagtcgaagaaggtgtgggcagaagaaaaagctagtgatcaacagtggcaatgg agctgtggaggacagaaagccaagtggactcaacggagaggccagcaagtctcaggaaat ggtgcatttggtgaacaaggagtcgtcagaaactccagaccagtttatzgacagctgatga gacaaggaacc >31540_at HG-U95AV2≫ 257_at HG-U95AV2 tagcaacagtcatttctgaaaatatgttggatagaaagtcactctttggcaaaagtgtta gaatttgcttttgtgccatctattccttttatggcatctatcttgaaagtaatcttgtat tggagattgaaagatgctgtaatttagaaattaacatgatatcttaaattacctttatga aatatagttttgtataatagcatagattttccttcaaaaaatgaacatttatatatctac aaaaatatggagaagagcaatttgaaagcctactttctgaagaaaatggtgggatttttt tttatcatgattaaatatcaaaaaattgccctatgaaaactttaaatctctaaaacattt gaaatactaccdtatttgtgatttattgagaataaaaatccattttgaaatgtaaaattt ttatgatctgattcagttttaagaa > 2 65_s__at HG-U95Av2 atgtctaatagttattccctatttgttttcttctgtatgttagggtgctctggaagagag gaatgcctgtgtgagcaagcatttatgtttatttataagcagatttaacaattccaaagg aatctccagttttcagttgatcactggcaatgaaaaattctcagtcagtaattgccaaag ctgctctagccttgaggagtgtgagaatcaaaactctcctacacttccattaacttagca tgtgttgaaaaaaaaagtttcagagaagttctggctgaacactggcaacgacaaagccaa cagtcaaaacagagatgtgataaggatcagaacagcagaggttcttttaaaggggcagaa aaactctgggaaataagagagaacaactactgtgatcaggctatgtatggaatacagtgt tattttctttgaaattgtttaagtgttgtaaatatttatgtaaactgcattagaaattag ctgtgtgaaatac cagtgtggtttgtgtttgagttttattgagaattttaaattataact taaaatattttataatttttaaagtatatatttatttaagcttatgtcagacctatttga cataacactataaa > 286_at HG-U95Av2 tcgccaggcaggagtttctctcggtgactactatcgctgtcatgtctggtcgtggcaagc aaggaggcaaggcccgcgccaaggccaagtcgcgctcgtcccgcgctggccttcagttcc cggtagggcgagtgcatcgcttgctgcgcaaaggcaactacgcggagcgagtgggggccg gcgcgcccgtctacatggctgcggtcctcgagtatctgaccgccgagatcctggagctgg cgggcaacgcggctcgggacaacaagaagacgcgcatcatccctcgtcacctccagctgg ccatccgcaacgacgaggaactgaacaagctgctgggcaaagtcaccatcgcccagggcg gcgtcttgcctaacatccaggccgtactgctccctaagaagacggagagtcaccacaagg caaagggcaagtgaggctgacgtccggcccaagtgggcccagcccggcccgcgtctcgaa ggggcacctgtgaactcaaaaggctctt > 287__at HG-U9 5Av2 gttaacacaaaatccatgggcagcatgatggcaggtcctctgttgcaaactcagttccaa agtcacaggaagaaagcagaaagttcaacttccaaagggttaggactctccactcaatgt cttaggtcaggagttgtgtctaggctggaagagccaaagaaatattccattttcctttcc ttgtggttgaaaccacagtcagtggagagatgtttggaacacagtcagtggagctggtgg taccaggtttagcattattggatgtcaaaagcattttttttgtcatgtagctgttttaag aaatctggcc cagggtgtttgcagctgtgagaagtcactcacactggccacaaggacgct 66- 98677.doc 200533758 ggctactgtctattaaaattctgatgtttctgtgaaattctcagagtgtttaatt > 31472_s_at HG-U95Av2 gacaagttttggtggcacgcagcctggggactctgcctcgtgccgctgagcctggcgcag atcgatttgaatatnnnnnnnnnnnnnnnnnnnnnattccacgtggagaaaaatggtcgc tacagcatctctcggacggaggccgctgacctctgcaaggctttcaatagcaccttgccc acaatggcccagatggagaaagctctgagcatcggatttgagacctgcagtttgcattgc agtcaacagtcgaagaaggtgtgggcagaagaaaaagctagtgatcaacagtggcaatgg agctgtggaggacagaaagccaagtggactcaacggagaggccagcaagtctcaggaaat ggtgcatttggtgaacaaggagtcgtcagaaactccagaccagtttatzgacagctgatga gacaaggaacc > 31540_at HG-U95AV2

atgagaccagtacaaactactcaagaggaagatggctgtagctnnnnnnnnnnnnnnnaa gaagaaggaggatgtgaactgtgaaatggaagtcaatagggctgttgggactttcttgaa aagaagcaaggaaatatgagtcatccgctatcacagctttcaaaagcaagaacaccatcc tacataatacccaggattcccccaacacacgttcttttctaaatgccaatgagttggcct ttaaaaatgcaccac nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnrmnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnt g ccaggcccg gccaaaataatgcaccacttttaacagaacagacag >31622_f_at HG-U95AV2 gtgtctcctgcacctgcgctggttcctgcaagtgcaaagagtgcaaatgcacctcctgca agaagagctgctgctcctgctgccccgtgggctgtagcaagtgtgcccagggctgtgttt gcaaag >31697_s_at HG-U95AV2 caaactggccactgacaaaaatgaccccnnnnnnnnnnnnnnnnnnnnnnnacattacct gaatgagcaggtgaaagccatcaaagaattgggtgaacgtgaccaannnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagctgtggggtgacttccctggtca ccaaggcagtgcatgcatgttggggtttcctttacctt >31803_at HG-U95Av2 aagtgggctgtggtgcccatttgcagtgactgtgaagtgactccaggacggacctgcggg ggcaccnagaggtcctaagccccaggactgagggtcgtgcatcaccactcgggtgtcccg ggaggtgccctgggcccggggacctcacaggcaggacggcgacactaatgcagggagagg gagtctggccccagcttttcctatcagaggcgattttccttcaccaggggatgggcagga aagaggcaggggccccagaagcttctgtccctcatgcctgagggcacgggggacacttgg annnnnnnnnnnnnnnngtgcgtccaaggccatgctctctgcgggtcagtgcctgagtct cgcctccctgctggtccctgaagccccctcannnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnccctctcagcccaacatcagcttcctctttctccctt gctgtagacaggctggat >31825一at HG-U95Av2 gaaacgaccaagaagagaggcttgttggaatcaattctnnnnnnnnnnnnnnnnnnnnnn nnnntagaagtcantgtaactgtagtgtgtctgctngttacctagagggtctnacctncc cnactcttcacagcaaacctgnagcagcgcgtncctaagcancctncccgctccnggtga nccccatccttgcanancctgactctgtcactcaagcctttctnccanccaggcccctca tctgaatanccaagcacagaaatgagtggtgtgactaattccttacctctcccaaggagg gtacacaactagcaccattcttgatgtnccagggaagaagccacctcaagacatatgagg ggtgccctgggctaatgttagggcttaattttctcaaagcctgacctttcaaatccannn nnnnnnnnnnnnnnccctcctgctgttgcctccctgtgacctggaggacagtgtgtgcca tgtctcccatactagagataaataaatgtagccacatttactgtnaaaaaaaaaaaaaaa aaactcgaggggggccggtacccaattcgccctatagctgagtcgt >31862_at HG-U95Av2 acatcccctcagttgcagtgaattgtgagcaaaagatcttgaaagcaaaaagcactaatt 67- 98677.doc 200533758 agtttaaaatgtcacttttttggtttttattatacaaaaaccatgaagtactttttttat ttgctaaatcagattgttcctttttagtgactcatgtttatgaagagagttgagtttaac aatcctagcttttaaaagaaactatttaatgtaaaatattctacatgtcattcagatatt atgtatatcttctagcctttattctgtacttttaatgtacatatttctgtcttgcgtgal: ttgtatatttcactggtttaaaaaacaaacatcgaaaggcttatgccaaatggaagatag aatataaaataaaacgttacttgtatannnnnaannnnnnnnaannnnnnnncagataat tcatgtggagatttttggagaaaccatgacggatagtttaggatgactacatgtcaaagt aataaaagagtggtgaattttaccaaaaccaagctatttggaagc >318 95__at HG-U95Av2 agtcttggttctccatctgtaattttttttaacagtttgctatagcttactgcttaacta attttaaataaggaaataagtatgttagatgcagtagacgatacaggttgcatgtggaca ctcagtcacattaacaacttgggaaaaaaatggcaatgttacggtgaattctcaggtgaa cttttttcagtta >31974___at HG-U95Av2 cagcggcatgaagtttgagattggccaggccctgtacctgggcttcatctcctncgtccc tctcgctcattggtggcaccctgctttgcctgtcctgccaggacgaggcaccctacnngc cctannccaggccccgcccagggccaccacgaccactgcaaacaccgcacctgcctaccaatgagaccagtacaaactactcaagaggaagatggctgtagctnnnnnnnnnnnnnnnaa gaagaaggaggatgtgaactgtgaaatggaagtcaatagggctgttgggactttcttgaa aagaagcaaggaaatatgagtcatccgctatcacagctttcaaaagcaagaacaccatcc tacataatacccaggattcccccaacacacgttcttttctaaatgccaatgagttggcct ttaaaaatgcaccac nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnrmnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnt g ccaggcccg gccaaaataatgcaccacttttaacagaacagacag > 31622_f_at HG-U95AV2 gtgtctcctgcacctgcgctggttcctgcaagtgcaaagagtgcaaatgcacctcctgca agaagagctgctgctcctgctgccccgtgggctgtagcaagtgtgcccagggctgtgttt gcaaag > 31697_s_at HG-U95AV2 caaactggccactgacaaaaatgaccccnnnnnnnnnnnnnnnnnnnnnnnacattacct gaatgagcaggtgaaagccatcaaagaattgggtgaacgtgaccaannnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagctgtggggtgac ttccctggtca ccaaggcagtgcatgcatgttggggtttcctttacctt > 31803_at HG-U95Av2 aagtgggctgtggtgcccatttgcagtgactgtgaagtgactccaggacggacctgcggg ggcaccnagaggtcctaagccccaggactgagggtcgtgcatcaccactcgggtgtcccg ggaggtgccctgggcccggggacctcacaggcaggacggcgacactaatgcagggagagg gagtctggccccagcttttcctatcagaggcgattttccttcaccaggggatgggcagga aagaggcaggggccccagaagcttctgtccctcatgcctgagggcacgggggacacttgg annnnnnnnnnnnnnnngtgcgtccaaggccatgctctctgcgggtcagtgcctgagtct cgcctccctgctggtccctgaagccccctcannnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnccctctcagcccaacatcagcttcctctttctccctt gctgtagacaggctggat > 31825 a at HG-U95Av2 gaaacgaccaagaagagaggcttgttggaatcaattctnnnnnnnnnnnnnnnnnnnnnn nnnntagaagtcantgtaactgtagtgtgtctgctngttacctagagggtctnacctncc cnactcttcacagcaaacctgnagcagcgcgtncctaagcancctncccgctccnggtga nccccatccttgcanancctgactctgtcactcaagcctttctnccanccaggcccctca tctgaatanccaagcacagaaatgagtggtgtgactaattccttacctctcccaaggagg gtacacaactagcaccattcttgatgtnccagggaagaagccacctcaagacatatgagg ggtgccctgggctaatgttagggcttaa ttttctcaaagcctgacctttcaaatccannn nnnnnnnnnnnnnnccctcctgctgttgcctccctgtgacctggaggacagtgtgtgcca tgtctcccatactagagataaataaatgtagccacatttactgtnaaaaaaaaaaaaaaa aaactcgaggggggccggtacccaattcgccctatagctgagtcgt > 31862_at HG-U95Av2 acatcccctcagttgcagtgaattgtgagcaaaagatcttgaaagcaaaaagcactaatt 67- 98677.doc 200533758 agtttaaaatgtcacttttttggtttttattatacaaaaaccatgaagtactttttttat ttgctaaatcagattgttcctttttagtgactcatgtttatgaagagagttgagtttaac aatcctagcttttaaaagaaactatttaatgtaaaatattctacatgtcattcagatatt atgtatatcttctagcctttattctgtacttttaatgtacatatttctgtcttgcgtgal: ttgtatatttcactggtttaaaaaacaaacatcgaaaggcttatgccaaatggaagatag aatataaaataaaacgttacttgtatannnnnaannnnnnnnaannnnnnnncagataat tcatgtggagatttttggagaaaccatgacggatagtttaggatgactacatgtcaaagt aataaaagagtggtgaattttaccaaaaccaagctatttggaagc > 318 95__at HG-U95Av2 agtcttggttctccatctgtaattttttttaacagtttgctatagcttactgcttaacta attttaaataaggaaataagtatgttagatgcagtagacgatacaggttgcatgtggaca ctcagtcacattaacaacttgggaaaaaaatggcaatgttacggtgaattctcaggtgaa cttttttc agtta > 31974 ___ at HG-U95Av2 cagcggcatgagattttgagattggccaggccctctaccacc

gccaccagctgcctacaaagacaatcgggccccctnagtgacctcggccanncacagcgg gtacaggctgaacgactacgtgtgagtccccacagcctgcttctcccctgggctgctgtg ggctggttcccggcgggactgtcaatggaggcaggggtnnnnnnnnnnnnnnnnnnnnnn nncaatttttgtatccaaggaaataatgtgaatgcgaggaaatgtctttagagcacaggg aca >32034一at HG_U95Av2 cctgttcacaagctgagccatatgtacataatctagattttgttttcatagttttgcact tttatagcctatttttgaagattaacacatttgcaagatgattgactcaatctttgccta atccaatgagtgttacagagagcttgctgtgactagaaccataaatcttaaagggggtat gtgataatagagggctggaatttaaacctgtatttaaaaaaaagaatcaccaaatctatt tgaaaacaagtcgatttgtattatgctggaattttttgggctttcagatttctcttttta accacatttctgaatgtataaaaataccaattattttcctacagccctttgtacttcaaa atatgtttttgtgtccatcagtattaactattg >32052一at HG-U95Av2 gctcgctttcttgctgtccaatttctattaaaggttcctttgttccctaagtccaactac taaactgggggatattatgaagggccttgagcatctggattctgcctaataaaa >32114_s_at HG-U95Av2 agcttgggcacagcagactggcctggccctgagactggggagtggctncnacagncctcc tgccacccacacaccactctccctagactctncctagggttcaggagctgctgggcccag aggtgacatttgacnttttttccaggaaaaatgtaagtgtgaggaaaccctttttatttt attacctttcactctctggctgctgggtctgccgtcggtcctgctnnnnnnnnnnnnnnn ngagcctctgcccggggagcctcaggcagtcctctcctgctgtcacagctgccatccact tctcagtcccagggccatctcttggagtgacaaagctgggatcaaggacagggagttgta acagagcagtgccagagcatgggcccaggtcccaggggagaggttggggctggcaggcca ctggcatgtgctgagtagcgcagagctacccagtgagaggccttgtctaactgcctttc >32115_r_at HG-U95Av2 ggtctgccgtcggtcctgctgctaacctggcagcagagcctctgcccggggagcc >32168_s__at HG-U95Av2 aacctacctgtgaatcatatgttgtaggaaaagctgttcccatgtctaacaggacttgaa ttcaaagcatgtcaagtggatagtagatctgtggcgatatgagagggatgcagtgccttt ccccnattcattcctgatggaattgttatactaggttaacatttgtaatttttttctagt tgtaatgtgtatgtctggtaaataggtattatattttggccttacaataccgtaacaatg tttgtcattttgaaatacttaatgccaagtaacaatgcatgctttggaaatttggaagat ggttttattctttgagaagcaaatatgtttgcattaaatgctttgattgttcatatcaag aaattgattgaacgttctcaaaccctgtttacggtacttggtaagagggagccggtttgg gagagaccattgcatcgctgtccaagtgtttcttgttaagtgcttttaaactggagaggc taacctcaaaatattttttttaactgcattctataataaatgggcacagtatgctcctta 68- 98677.doc 200533758 c >32215_i_at HG-U95Av2 aacagattactgtctattgtcagcatcattttcatctgtaagtcactactggaatatatt >32216_r__at HG-U95Av2 aaatggactgggatagaggacagactgatagtttctttctttcatatcacatgtatagag aaataattatatcagaanctcacaaacctagacatggaaaaacagattactgtctattgt cagcatcattttcatctgtaagtcactactggaatatatttttcttttaatttccagtga ctttagaatacacacagttttt >32285_g_at HG-U95Av2 ctatgtggacccacgcaaagatagcgagaaatatgccgaggagaacttcaaaacctttgt gttcgaggagacacgattcaccgcggtcactgcctaccagaaccatcggatcacgcagct caagattgccagcaatcccttcgcgaaaggcttccgggactgtgaccctga >32319一at HG-U95Av2 gtctatgttcttgttgctatgagtcaaggagtgtaaccttctcctttactatgttgaatg tatttttttctggacaagcttacatcttcctcagccatctttgtgagtccttcaagagcagccaccagctgcctacaaagacaatcgggccccctnagtgacctcggccanncacagcgg gtacaggctgaacgactacgtgtgagtccccacagcctgcttctcccctgggctgctgtg ggctggttcccggcgggactgtcaatggaggcaggggtnnnnnnnnnnnnnnnnnnnnnn nncaatttttgtatccaaggaaataatgtgaatgcgaggaaatgtctttagagcacaggg aca > 32034 a at HG_U95Av2 cctgttcacaagctgagccatatgtacataatctagattttgttttcatagttttgcact tttatagcctatttttgaagattaacacatttgcaagatgattgactcaatctttgccta atccaatgagtgttacagagagcttgctgtgactagaaccataaatcttaaagggggtat gtgataatagagggctggaatttaaacctgtatttaaaaaaaagaatcaccaaatctatt tgaaaacaagtcgatttgtattatgctggaattttttgggctttcagatttctcttttta accacatttctgaatgtataaaaataccaattattttcctacagccctttgtacttcaaa atatgtttttgtgtccatcagtattaactattg > 32052 a at HG-U95Av2 gctcgctttcttgctgtccaatttctattaaaggttcctttgttccctaagtccaactac taaactgggggatattatgaagggccttgagcatctggattctgcctaataaaa > 32114_s_at HG-U95Av2 agcttgggcacagcagactggcctggccctgagactggggagtggctncnacagncctcc tgccacccacacaccactctccctagactctncctagggttcaggagctgctgggcccag aggtgacatttgacnttttttccaggaaaaatgtaagtg tgaggaaaccctttttatttt attacctttcactctctggctgctgggtctgccgtcggtcctgctnnnnnnnnnnnnnnn ngagcctctgcccggggagcctcaggcagtcctctcctgctgtcacagctgccatccact tctcagtcccagggccatctcttggagtgacaaagctgggatcaaggacagggagttgta acagagcagtgccagagcatgggcccaggtcccaggggagaggttggggctggcaggcca ctggcatgtgctgagtagcgcagagctacccagtgagaggccttgtctaactgcctttc > 32115_r_at HG-U95Av2 ggtctgccgtcggtcctgctgctaacctggcagcagagcctctgcccggggagcc > 32168_s__at HG-U95Av2 aacctacctgtgaatcatatgttgtaggaaaagctgttcccatgtctaacaggacttgaa ttcaaagcatgtcaagtggatagtagatctgtggcgatatgagagggatgcagtgccttt ccccnattcattcctgatggaattgttatactaggttaacatttgtaatttttttctagt tgtaatgtgtatgtctggtaaataggtattatattttggccttacaataccgtaacaatg tttgtcattttgaaatacttaatgccaagtaacaatgcatgctttggaaatttggaagat ggttttattctttgagaagcaaatatgtttgcattaaatgctttgattgttcatatcaag aaattgattgaacgttctcaaaccctgtttacggtacttggtaagagggagccggtttgg gagagaccattgcatcgctgtccaagtgtttcttgttaagtgcttttaaactggagaggc taacctcaaaatattttttttaactgcattctataataaatgggcacagtatgctcctta 68- 98677.doc 2005 33758 c > 32215_i_at HG-U95Av2 aacagattactgtctattgtcagcatcattttcatctgtaagtcactactggaatatatt > 32216_r__at HG-U95Av2 aaatggactgggatagaggacagactgatagtttctttctttcatatcacatgtatagag aaataattatatcagaanctcacaaacctagacatggaaaaacagattactgtctattgt cagcatcattttcatctgtaagtcactactggaatatatttttcttttaatttccagtga ctttagaatacacacagttttt > 32285_g_at HG-U95Av2 ctatgtggacccacgcaaagatagcgagaaatatgccgaggagaacttcaaaacctttgt gttcgaggagacacgattcaccgcggtcactgcctaccagaaccatcggatcacgcagct caagattgccagcaatcccttcgcgaaaggcttccgggactgtgaccctga > 32319 a at HG-U95Av2 gtctatgttcttgttgctatgagtcaaggagtgtaaccttctcctttactatgttgaatg tatttttttctggacaagcttacatcttcctcagccatctttgtgagtccttcaagagca

gttatcaattgttagttagatattttctatttagagaatgcttaagggattccaatcccg atccaaatcataatttgttcttaagtatactgggcaggtcccctattttaagtcataatt ttgtatttagtgctttcctggctctcagagagtattaat >32321__at HG-U95Av2 ccacagagagcctccactagagtgatgctaagtggaaatgtgaggtgcagctgccacaga gggcccccaccagggaaatgtctagtgtctagtggatccaggccacaggagagagtgnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntccc acagataccttttctctcccatgaccctttaacagcatctgcttcattcccctcaccttc ccaggctgatctgaggtaa >323_at HG-U95Av2 TIGRSequence >32464_at HG-U95Av2 gagggtcttgtatctcctcttctcgttcctcttcatattcctgatgcctcttccaggtgt ttttggtggtataggcgatcctgttacctgccttaagagtggagccatatgtcatccagt cttttgccctagaaggtataaacaaattggcacctgtggtctccctnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntgcggattcagaaagggctcc ctcatcagagacgtgcgacatgtaaaccaa >32531_at HG-U95Av2 tagtactgtaaacaggctttagtcattaatgtgagagacttagaaaaaatgcttagagtg gactattaaatgtgcctaaatgaattttgcagtaactggtattcttgggttttcctactt aatacacagtaattcagaacttgtattctattatgagtttagcagtcttttggagtgacc agcaactttgatgtttgcactaagattttatttggaatgcaagagaggttgaaagaggat tcagtagtacacatacaactaatttatttgaactatatgttgaagacatctaccagtttc tccaaatgccttttttaaaactcatcacagaagattggtgaaaatgctgagtatgacact tttcttcttgcatgcatgtcagctacataaacagttttgtacaatgaaaattactaattt gtttgacattccatgttaaactacg >32551_at HG-U95Av2 attttcatatccagcctaaaggtggttgtttattatatagtaataaatcattgctgtaca atannnnnnnnnnnnnannnnannnnnnnttttgtcaganantttagattgtgaatattt tgtaaaaaacagtaagcaaaattttccagaattcccaaaatgaaccagatatcccctaga aaattatactattgagaaatctatggggaggatatgagaaaataaattccttctaaacca cattggaactgacctgaagaagcaaactcggaaaatataataacatccctgaattcagga cttccacaagatgcagaacaaaatggataaaaggtatttcactggagaagttttaatttc taagtaaaatttaaatcctaacacttcactaatttataactaaaatttctcatcttcgta 69- 98677.doc 200533758 cttgatgctcacagaggaagaaaatgatgatggtttttattcctggcatccagagtgaca >32588_s__at HG-U95Av2 catctccgacgactgaggcaagagggcgccagtgaggaggaagggaaggcggttcagaga tgttggaggacacccctcgccatctcgcccttgctgggggcacgggagtggggggggtga catgggccctaggcagactgcaagcccgaccgagcacttggactcgaactctgtgcc >32606一at HG-U95Av2 acagaactacaggtgcacccaaccacggacatgcattaactcgtcatgagaaatctaggt aggctaagtaggatgagagaatgtttgtcactcccaaaaatatctggagaggaagaatgg aggattggcattgagatccatgtggacaagctaagtgggctctgtctgaaagctggcatt catccacaacattaaaaaaatatcaaaataagaaaggctgtaaattaaaaagaaaacaca gaaaatactgctctcataaagatctgattgccttgnnacaggccctgtgngannnnntca aacgcatcactcccaactcccattgcagaagaaaagctattcaactctcagcggtggagg a g t g c a t nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc agacgcggatctt ggaaatccaggacttcttggnnaagttgactgaaggtatattagatatttccccacaaaa atactatttggattctcccaccccctccctcccttgatgggacaacatcctgta >32 609__at HG-U95Av2gttatcaattgttagttagatattttctatttagagaatgcttaagggattccaatcccg atccaaatcataatttgttcttaagtatactgggcaggtcccctattttaagtcataatt ttgtatttagtgctttcctggctctcagagagtattaat > 32321__at HG-U95Av2 ccacagagagcctccactagagtgatgctaagtggaaatgtgaggtgcagctgccacaga gggcccccaccagggaaatgtctagtgtctagtggatccaggccacaggagagagtgnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntccc acagataccttttctctcccatgaccctttaacagcatctgcttcattcccctcaccttc ccaggctgatctgaggtaa > 323_at HG-U95Av2 TIGRSequence > 32464_at HG-U95Av2 gagggtcttgtatctcctcttctcgttcctcttcatattcctgatgcctcttccaggtgt ttttggtggtataggcgatcctgttacctgccttaagagtggagccatatgtcatccagt cttttgccctagaaggtataaacaaattggcacctgtggtctccctnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntgcggattcagaaagggctcc ctcatcagagacgtgcgacatgtaaaccaa > 32531_at HG-U95Av2 tagtactgtaaa caggctttagtcattaatgtgagagacttagaaaaaatgcttagagtg gactattaaatgtgcctaaatgaattttgcagtaactggtattcttgggttttcctactt aatacacagtaattcagaacttgtattctattatgagtttagcagtcttttggagtgacc agcaactttgatgtttgcactaagattttatttggaatgcaagagaggttgaaagaggat tcagtagtacacatacaactaatttatttgaactatatgttgaagacatctaccagtttc tccaaatgccttttttaaaactcatcacagaagattggtgaaaatgctgagtatgacact tttcttcttgcatgcatgtcagctacataaacagttttgtacaatgaaaattactaattt gtttgacattccatgttaaactacg > 32551_at HG-U95Av2 attttcatatccagcctaaaggtggttgtttattatatagtaataaatcattgctgtaca atannnnnnnnnnnnnannnnannnnnnnttttgtcaganantttagattgtgaatattt tgtaaaaaacagtaagcaaaattttccagaattcccaaaatgaaccagatatcccctaga aaattatactattgagaaatctatggggaggatatgagaaaataaattccttctaaacca cattggaactgacctgaagaagcaaactcggaaaatataataacatccctgaattcagga cttccacaagatgcagaacaaaatggataaaaggtatttcactggagaagttttaatttc taagtaaaatttaaatcctaacacttcactaatttataactaaaatttctcatcttcgta 69- 98677.doc 200533758 cttgatgctcacagaggaagaaaatgatgatggtttttattcctggcatccagagtgaca > 32588_s__at HG-U95Av 2 catctccgacgactgaggcaagagggcgccagtgaggaggaagggaaggcggttcagaga tgttggaggacacccctcgccatctcgcccttgctgggggcacgggagtggggggggtga catgggccctaggcagactgcaagcccgaccgagcacttggactcgaactctgtgcc > 32606 a at HG-U95Av2 acagaactacaggtgcacccaaccacggacatgcattaactcgtcatgagaaatctaggt aggctaagtaggatgagagaatgtttgtcactcccaaaaatatctggagaggaagaatgg aggattggcattgagatccatgtggacaagctaagtgggctctgtctgaaagctggcatt catccacaacattaaaaaaatatcaaaataagaaaggctgtaaattaaaaagaaaacaca gaaaatactgctctcataaagatctgattgccttgnnacaggccctgtgngannnnntca aacgcatcactcccaactcccattgcagaagaaaagctattcaactctcagcggtggagg a g t g c a t nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc agacgcggatctt ggaaatccaggacttcttggnnaagttgactgaaggtatattagatatttccccacaaaa atactatttggattctcccaccccctccctcccttgatgggacaacatcctgta > 32 609__at HG-U95Av2

gcccgcgtctcgaaggggcacctgtgaactcaaaaggctcttttc >32610_at HG-U95Av2 acctgggctccgaggtgtacaggatgctgcggganccagccgagcccgtggccgcggagc ccaagcagtcaggctccttccgctacttgnagggcatgctanaggccggcgagggcgggg attggcccgnncctggcggcccccggaacctcaagcccacggccagcaagctgggcgctc cgctgancggcctgcaggggctgcccgagtgcacgcgctgcggccacggcatcgtgggca ccatcgtcaaggcacgggacaagctctaccatcccgagtgcttcatgtgcagtgactgcg gcctgaacctcaagcagegtggttacttctttctggacgagcggctctactgtgagagcc acgccaaggcgcgcgtgaanccncccgagggctacgacgtggtggcggtgtaccccaatg ccaaggtggaactcgtntgagctgggaccctgctcccacgcctgcttcttaaggtccctg ctcggccggtgtaaatatgtttcac >32616_at HG-U95Av2 aataccagcagcagccttagagcacagggagacccgtccatttggcaggggtggctgcct catttagagaggaaaagtaaccatcactggttgcacttatgattteatgtgcggggatca tctgccgtgeetggatcctgaaatagaggctaaattactcaggaagaacaccctctaaat gggaaagtattctgtactcttagatggattctccactcagttgcaacttggacttgtcct cagcagctggtaatcttgctctgcttgacaacatctgagtgcagccgtttgagaagaaaa catctattctctccaaaaatgcacccaactagctctatgtttacaaatgg >32 64 0__at HG-U95Av2 gtgatttttctatcggcacaaaagcactatatggactggtaatggttacaggttcagaga ttacccagtgaggccttattcctcccttccccccaaaactgacacctttgttagccacct ccccacccacatacatttctgccagtgttcacaatgacactcagcggtcatgtctggaca tgagtgcccagggaatatgcccaagctatgccttgtcctcttgtcctgtttgcatttcac tgggagcttgcactannnnnnnnnnnnnnnnnngcagtgatcagggtcctgcaagcagt >32668一at HG-U95AV2 tcccctcttttgtgaagaaagcgggtccaaatgtgattcaaacaactgtacggagtggca tattagaattgccctaaactgaactgcaaataattatgtgtgtatgtatatgtgtgggaa agagaatgtactgtatatgtgtatgttatacagacatatacacatacatacattgaccca caggacattgtaaaatattatcacatgacatcttaagtagaaataagtagggacttttat tccatcctttttttcacgtttacattttaattattacaagttgctcctgccccctccctg aactattttgtgctgtgtatatcactgctttatataagttattttttaaggtgaactcag atgttatggttttgtaaatgtctgcaatcatggataggaataaaatcgcttatttgagag ctttcattaaa >32700_at HG-U95Av2 agtactaccaggtgccaaggaaggggatncaggccaaagaggtgctgaaaaaatatttgg agtcnnaggagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncactctcagaaaagg aaaaagcgattgaagtggaacgtataaaggctgaatctgcagaagctgcaaagaaaatgt 70- 98677.doc 200533758 tggaggaaatacaaaagaagaatgaggagatgatggaacagaaagagaannnnnnnnnnn nnnnngtgaaacaattgactgagaagatggagagggacagggcccagttaatggcagagc aagagaagaccctcgctcttaaacttcaggaacaggaacgccttctcaaggagggattcg agaatgagagcaagagacttcaaaaagacatatgggatatccagatgagaagcaaatcan nnnnnnnnnnnnnnaacatactctaaaagtccaaggagcaaaatttgcctgtccagctcc ct >32718__at HG-U95Av2 cagactgagcaagtggagtagcagaaccaggagcctcttcnnnncnnnaggaaagatnnn nnnnnnnnnnnnnnaagggaaattcctaggattggctgtcccctgccaagcttggtggag cgtctgcaccttggctgcgccgcctgtgcatttgccagtttcctcccactgagaggatgg aggtgtccgcacagctttgggcctcgtgagggatctgncctcctgagcaaagagctcttg atcccgatttcatgcacagccctgcagtaaggagcccagaaggaacatgtgtttcctgtt aaaactcctcttgttctcttttcttacattatgacgtttgttttcaaggagagggtttaa aaatgggatcctgtaagcagacttgggcagtctccttttgaaataggttgtctgtacatg ttctaatgttttgtagaacac >32736_at HG-U95Av2 tcctgccttcctgagggccagaggggagccccaggacccattaagccacccccgtgttccgcccgcgtctcgaaggggcacctgtgaactcaaaaggctcttttc > 32610_at HG-U95Av2 acctgggctccgaggtgtacaggatgctgcggganccagccgagcccgtggccgcggagc ccaagcagtcaggctccttccgctacttgnagggcatgctanaggccggcgagggcgggg attggcccgnncctggcggcccccggaacctcaagcccacggccagcaagctgggcgctc cgctgancggcctgcaggggctgcccgagtgcacgcgctgcggccacggcatcgtgggca ccatcgtcaaggcacgggacaagctctaccatcccgagtgcttcatgtgcagtgactgcg gcctgaacctcaagcagegtggttacttctttctggacgagcggctctactgtgagagcc acgccaaggcgcgcgtgaanccncccgagggctacgacgtggtggcggtgtaccccaatg ccaaggtggaactcgtntgagctgggaccctgctcccacgcctgcttcttaaggtccctg ctcggccggtgtaaatatgtttcac > 32616_at HG-U95Av2 aataccagcagcagccttagagcacagggagacccgtccatttggcaggggtggctgcct catttagagaggaaaagtaaccatcactggttgcacttatgattteatgtgcggggatca tctgccgtgeetggatcctgaaatagaggctaaattactcaggaagaacaccctctaaat gggaaagtattctgtactcttagatggattctccactcagttgcaacttggacttgtcct cagcagctggtaatcttgctctgcttgacaacatctgagtgcagccgtttgagaagaaaa catctattctctccaaaaatgcacccaactagctctatgtttacaaatgg > 32 64 0__at HG-U95Av2 gtgatttttcta tcggcacaaaagcactatatggactggtaatggttacaggttcagaga ttacccagtgaggccttattcctcccttccccccaaaactgacacctttgttagccacct ccccacccacatacatttctgccagtgttcacaatgacactcagcggtcatgtctggaca tgagtgcccagggaatatgcccaagctatgccttgtcctcttgtcctgtttgcatttcac tgggagcttgcactannnnnnnnnnnnnnnnnngcagtgatcagggtcctgcaagcagt > 32668 a at HG-U95AV2 tcccctcttttgtgaagaaagcgggtccaaatgtgattcaaacaactgtacggagtggca tattagaattgccctaaactgaactgcaaataattatgtgtgtatgtatatgtgtgggaa agagaatgtactgtatatgtgtatgttatacagacatatacacatacatacattgaccca caggacattgtaaaatattatcacatgacatcttaagtagaaataagtagggacttttat tccatcctttttttcacgtttacattttaattattacaagttgctcctgccccctccctg aactattttgtgctgtgtatatcactgctttatataagttattttttaaggtgaactcag atgttatggttttgtaaatgtctgcaatcatggataggaataaaatcgcttatttgagag ctttcattaaa > 32700_at HG-U95Av2 agtactaccaggtgccaaggaaggggatncaggccaaagaggtgctgaaaaaatatttgg agtcnnaggagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncactctcagaaaagg aaaaagcgattgaagtggaacgtataaaggctgaatctgcagaagctgcaaagaaaatgt 70- 98677.doc 200533758 tggaggaaatacaa aagaagaatgaggagatgatggaacagaaagagaannnnnnnnnnn nnnnngtgaaacaattgactgagaagatggagagggacagggcccagttaatggcagagc aagagaagaccctcgctcttaaacttcaggaacaggaacgccttctcaaggagggattcg agaatgagagcaagagacttcaaaaagacatatgggatatccagatgagaagcaaatcan nnnnnnnnnnnnnnaacatactctaaaagtccaaggagcaaaatttgcctgtccagctcc ct > 32718__at HG-U95Av2 cagactgagcaagtggagtagcagaaccaggagcctcttcnnnncnnnaggaaagatnnn nnnnnnnnnnnnnnaagggaaattcctaggattggctgtcccctgccaagcttggtggag cgtctgcaccttggctgcgccgcctgtgcatttgccagtttcctcccactgagaggatgg aggtgtccgcacagctttgggcctcgtgagggatctgncctcctgagcaaagagctcttg atcccgatttcatgcacagccctgcagtaaggagcccagaaggaacatgtgtttcctgtt aaaactcctcttgttctcttttcttacattatgacgtttgttttcaaggagagggtttaa aaatgggatcctgtaagcagacttgggcagtctccttttgaaataggttgtctgtacatg ttctaatgttttgtagaacac > 32736_at HG-U95Av2 tcctgccttcctgagggccagaggggagccccaggacccattaagccacccccgtgttcc

tgccgtcagtgccaacnnnnnnnnnnnnnnncatctacccgttcactccagtcccacccc acgcctgactcccctctggaaactgcaggccagatggttgctgccacaacttgtgtacct tcagggatggggctcttactccctcctgaggccagctnnncnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnaaatgagtgtctcagaagtgtgctcctctggc ctcagttctcctcttttggaacaacataaaacaaatttaattttctacgcctctggggat atctgctcagccaatggaaaatctgggttcaaccagcccctgccatttcttaagactttc tgctncactcacaggatcctgagctgcacttacctgtgagagtcttcaaacttttaaacc ttgccagtcaggactttt >32737—at HG-U95Av2 acagacggacgtcttcctcatctgcttctccctcgtcagcccagcctcttatgagaacgt ccgcgccaagtggttcccagaagtgcggcaccactgccccagcacacccatcatcctggt gggcaccaagctggacctgcgggacgacaaggacaccatcgagaaactgaaggagaagaa gctggctcccatcacctacccgcaggncnnnnggcactggccaaggagattgactcggtg aaatacctggagtgctcagcnctnacccnagagaggcctgaaaaccgtgttcgacgangc catccgggcngtgctgtgccctcagcccacgcggcannnnnnnnnnnnnnnnnnnnnnct cctctaggggttngcanccnnnnnnnncnnnntagatnggtntgntncnncnnnnnnnna ggnncncgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggagcccttcacgggacg ctacagcctgtgcc >32772_s__at HG-U9 5Av2 ggagacactatattcaatcgtgctaagctcctcaatgttggctttcaagaagccttgaag gactatgactacacctgctttgtgtttagtgacgtggacctcatnccaatgaatgaccat aatgcgtacaggtgtttttcacagccacggcacatttccgttgcaatggataagtttgga ttcagcctaccttatgttcagtattttggaggtgtctctgctctaagtaaacaacagttt ctaacnnnnnnnnnnnnnnntaataattattggggctgnggaggngnagatgatgacatt nttaacagattagtttttagaggcatgtctatatctc >32786_at HG-U95Av2 cgcttggacggctgggcacacgcctcccactggggtccagggagcaggcggtgggcaccc accctgggacctaggggcgccgcaaaccacactggactccggccctcctaccctgcgccc agtccttccacctcgacgtttacaagcccccccttccacttttttttgtatgtttttttt ctgctggaaacagactcgattcatattgaatataatatatttgtgtatttaacagggagg ggaagagggggcgantcnnnggcggagctggccccgccgcctggtactcaagcccgcggg gacattgggaaggggacccccgccccctgccctcccctctntgcaccgtactgtggaaaa gaaacacgcacttagtctctaaagagtttatt >327 94_g__at HG-U95Av2 gactccagatactgcctgagcagccgcctgagggtctcggnnnnnnnnnnnnnnnnnncc cgcaaccacttccgctgtcaagtccagttctacgggctctcggagaatgacgagtggacc caggatagggccaaacccgtcacccagatcgtcagcgccgaggcctggggtagagcagac tgtggcttnacctcngngtcntaccagcaaggggtcctgtctgccaccatcctctatgag -71 - 98677.doc 200533758 at >32818_at HG-U95Av2 tagaaccagccgtattttacatgaagctgtataattaattgtcattatttttgttagcaa agattaaatgtgtcattggaagccatccctttttttacatttcatacaacagaaaccaga aaagcaatactgtttccattttaaggatatgattaatattattaatataataatgatgat gatgatgatgaaaactaaggatttttcaagagatctttctttccaaaacatttctggaca gtacctgattg >32847一at HG-U95Av2 tccaaggaccggatgaagaagtacatggcaagaaggaantggcagaaaacgggcaatgct gtgagagccattngnagactgtcctctnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnagggtcanccaaccagcccgctcaatgcagaaaaactagaatctnnngaag atgtgtcccaagctttccttgaggctgttgctgaggaaaagcctcatgtaaaaccctatt tctctaagaccattcgcgatttagaagttgtggagggaagtgctgctagatttgactgca agattgaannnnnnnnnnnnnnnnaggttgtctggttcaaagatgaccagtcaatcaggg agtcccgccacttccagatagactacgatgaggnnnnnnnnnnnnnnnnaattattagtg atgtttgcggggatgacgatgccaagtacacctgcaaggctgtcaacagtcttggagaag ccacctgca5Av2 32772_s__at HG-U9; tgccgtcagtgccaacnnnnnnnnnnnnnnncatctacccgttcactccagtcccacccc acgcctgactcccctctggaaactgcaggccagatggttgctgccacaacttgtgtacct tcagggatggggctcttactccctcctgaggccagctnnncnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnaaatgagtgtctcagaagtgtgctcctctggc ctcagttctcctcttttggaacaacataaaacaaatttaattttctacgcctctggggat atctgctcagccaatggaaaatctgggttcaaccagcccctgccatttcttaagactttc tgctncactcacaggatcctgagctgcacttacctgtgagagtcttcaaacttttaaacc ttgccagtcaggactttt > 32737-at HG-U95Av2 acagacggacgtcttcctcatctgcttctccctcgtcagcccagcctcttatgagaacgt ccgcgccaagtggttcccagaagtgcggcaccactgccccagcacacccatcatcctggt gggcaccaagctggacctgcgggacgacaaggacaccatcgagaaactgaaggagaagaa gctggctcccatcacctacccgcaggncnnnnggcactggccaaggagattgactcggtg aaatacctggagtgctcagcnctnacccnagagaggcctgaaaaccgtgttcgacgangc catccgggcngtgctgtgccctcagcccacgcggcannnnnnnnnnnnnnnnnnnnnnct cctctaggggttngcanccnnnnnnnncnnnntagatnggtntgntncnncnnnnnnnna ggnncncgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggagcccttcacgggacg ctacagcctgtgcc & gt ggagacactatattcaatcgtgctaagctcctcaatgttggctttcaagaagccttgaag gactatgactacacctgctttgtgtttagtgacgtggacctcatnccaatgaatgaccat aatgcgtacaggtgtttttcacagccacggcacatttccgttgcaatggataagtttgga ttcagcctaccttatgttcagtattttggaggtgtctctgctctaagtaaacaacagttt ctaacnnnnnnnnnnnnnnntaataattattggggctgnggaggngnagatgatgacatt nttaacagattagtttttagaggcatgtctatatctc > 32786_at HG-U95Av2 cgcttggacggctgggcacacgcctcccactggggtccagggagcaggcggtgggcaccc accctgggacctaggggcgccgcaaaccacactggactccggccctcctaccctgcgccc agtccttccacctcgacgtttacaagcccccccttccacttttttttgtatgtttttttt ctgctggaaacagactcgattcatattgaatataatatatttgtgtatttaacagggagg ggaagagggggcgantcnnnggcggagctggccccgccgcctggtactcaagcccgcggg gacattgggaaggggacccccgccccctgccctcccctctntgcaccgtactgtggaaaa gaaacacgcacttagtctctaaagagtttatt > 327 94_g__at HG-U95Av2 gactccagatactgcctgagcagccgcctgagggtctcggnnnnnnnnnnnnnnnnnncc cgcaaccacttccgctgtcaagtccagttctacgggctctcggagaatgacgagtggacc caggatagggccaaacccgtcacccagatcgtcagcgccgaggcctggggtagagcagac tgtggcttnacctcngngtcntac cagcaaggggtcctgtctgccaccatcctctatgag -71 - 98677.doc 200533758 at > 32818_at HG-U95Av2 tagaaccagccgtattttacatgaagctgtataattaattgtcattatttttgttagcaa agattaaatgtgtcattggaagccatccctttttttacatttcatacaacagaaaccaga aaagcaatactgtttccattttaaggatatgattaatattattaatataataatgatgat gatgatgatgaaaactaaggatttttcaagagatctttctttccaaaacatttctggaca gtacctgattg > 32847 a at HG-U95Av2 tccaaggaccggatgaagaagtacatggcaagaaggaantggcagaaaacgggcaatgct gtgagagccattngnagactgtcctctnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnagggtcanccaaccagcccgctcaatgcagaaaaactagaatctnnngaag atgtgtcccaagctttccttgaggctgttgctgaggaaaagcctcatgtaaaaccctatt tctctaagaccattcgcgatttagaagttgtggagggaagtgctgctagatttgactgca agattgaannnnnnnnnnnnnnnnaggttgtctggttcaaagatgaccagtcaatcaggg agtcccgccacttccagatagactacgatgaggnnnnnnnnnnnnnnnnaattattagtg atgtttgcggggatgacgatgccaagtacacctgcaaggctgtcaacagtcttggagaag ccacctgca

>32944_at HG-U95Av2 accagaccagccaagaaactgaaacnnnnnnnnnnnnnnnnnnnnngagaaacctacaca gatgatcttccaccacctcctgtgccgccacctgctataaagtcacctactgcccaatcc aagacacagctggaagtacgnnnnnnnnnnnnnnnaaaactcccttctatggatgcaaga acagacagannnnnnnnnnnnnnnngaagcagttacaaggggagagaagtgttggatgga agacaggttgttgacatgcgaacaaatccaggtgatcccagagaagcacaggaacagcaa aatgacgggaaaggacgtggaaacaaggcagcaaaacgagaccttccaccagcaaagact catctcatccaagaggatattctaccttattgtagacctacttttccaacatcaaataat cccagagatcccagttcctcaagctcaatgtcatcaagaggatcaggaagcagacaaaga gaacaagcaaatgtaggtcgaagaaatattgcagaaatgcaggtacttggaggatatgaa agaggagaagataataatgaagaattagaggaaactgaaagctgaagacaaccaagaggc tt >33102一at HG-U95AV2 atatttttggagtcccattgtttcagtgggcattaacagaatgctttaaaaacttctaag acaagadtctatagcattagtatacactggcacataattttttaaaaagttttaagaaaa gattcatttggaattttattcacagtataaaatttcctcacctgaagtaactttgtttgc caa >33103_s_at HG-U95Av2 tctcacagaaggagaacttgaagagtataagaggacaatcgaacgtaaacaacaaggcct agaagaaaaccatgagctgttttccaagagcttcatctccatggaagtgcctgtcatggt agtaaatggcaaggatgatatgcatgatgttgaagatgagettgctaagcgagtgagtag gttaagcacaagtacaaccatagaaaacatcgagattactattaagtctccagagaaaat cgaagaagtcctgtcacctgaaggctccccttcaaaatcgccatccaagaaaaagaagaa attccgcactccttcttttctgaaaaagaacaaaaaaaaggagaaagttgaggcctaaat aaagtctttttataattattattataacaatgtgacattgcacatctaaataccacattt aagttgatcattaatatgcaatggtagatcagattgggggatgtagcaaactggacttta agaac >33113一at HG-U95AV2 tttctccagtgctcaactgttagatattaatcttggcaaactgcttaatcttgtggattt nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagtgaaaggaaaaattgca ttagttggttgcatgaacttcngangggcagatattactgcacaaactgccatctcgctt catttttttaactatgncatttgagtancaganctaatttttaaaatatgctaaactgga anngattannnnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnntggctgtcccccccgccgccccccccacccccatatgtacagatgataat agggtgtggaatgtcgtcagtggcaaacatttcacagannnttattttgtttctgtcttc aacatttttgacactgtgctaatagttatattc >33130 at HG-U95Av2 72- 98677.doc 200533758 cttgtaagccacttgtttggttatgatttgtgtcttatcagggaaaaggtgcccagctgc cagcccagctccgctgcntatctttgcctcacttagtcatgtgcaattcgcgttgcagag tggcagaccattagttgctgagnnnnnnnnnnnnnnnnntgtgctcagaagagcacctgc ccaaagtttttctggttttaatttaaaggacaaggctacatatattcagctttttgagat gaccaaagctagttagggtctccttgatgtagctaagctgcttcagtgatcttcacattt gcactccagttttttnnnnnnnnnnnnnnnnnnttctacctctctatgtgcctgagtgat gatacaatcgctgtttagttactagatgaacaaatccacagaatgggtaaagagtagaat ctgaactatatcttgacaaatattattcaaacttgaatgtaaatatatacagtatgtata ttttttaaaaagatttgcttgcaatgaccttata >33235_at HG-U95Av2 gtgtcacaaagtcaataggtccttannnnnnnnnnnnnnnctaagggaaatccgaactga atttatgcacatagaattgtcaccctgactttgaagcctcaaacatggatcaaatctgtt gtgaaacatcaatatatgtagctggatgagtgactagtttcccttgtataatatgtgatc taagaaaattgctaatctttccctgccattttgagaaacacagtccaaacatgagcataa acagaatttcctgcaatacatncccagtaggtnccacctagtttacaacttaaactagtt tgtgaaacatttgtctgtatacattttatattttgtacattttgatgtaacatatcatgt aaataggcagaaacagtgaaataaatcatctgaaaagttttgtagtctttgtaaagcccc aacaataagtacttggtgtcaatggacttaactggatgatgtattttctattggtttatt≫ 32944_at HG-U95Av2 accagaccagccaagaaactgaaacnnnnnnnnnnnnnnnnnnnnngagaaacctacaca gatgatcttccaccacctcctgtgccgccacctgctataaagtcacctactgcccaatcc aagacacagctggaagtacgnnnnnnnnnnnnnnnaaaactcccttctatggatgcaaga acagacagannnnnnnnnnnnnnnngaagcagttacaaggggagagaagtgttggatgga agacaggttgttgacatgcgaacaaatccaggtgatcccagagaagcacaggaacagcaa aatgacgggaaaggacgtggaaacaaggcagcaaaacgagaccttccaccagcaaagact catctcatccaagaggatattctaccttattgtagacctacttttccaacatcaaataat cccagagatcccagttcctcaagctcaatgtcatcaagaggatcaggaagcagacaaaga gaacaagcaaatgtaggtcgaagaaatattgcagaaatgcaggtacttggaggatatgaa agaggagaagataataatgaagaattagaggaaactgaaagctgaagacaaccaagaggc tt > 33102 a at HG-U95AV2 atatttttggagtcccattgtttcagtgggcattaacagaatgctttaaaaacttctaag acaagadtctatagcattagtatacactggcacataattttttaaaaagttttaagaaaa gattcatttggaattttattcacagtataaaatttcctcacctgaagtaactttgtttgc caa > 33103_s_at HG-U95Av2 tctcacagaaggagaacttgaagagtataagaggacaatcgaacgtaaacaacaaggcct agaagaaaaccatgagctgttttccaagagcttcatctccatggaagtgcctgtcatggt agtaa atggcaaggatgatatgcatgatgttgaagatgagettgctaagcgagtgagtag gttaagcacaagtacaaccatagaaaacatcgagattactattaagtctccagagaaaat cgaagaagtcctgtcacctgaaggctccccttcaaaatcgccatccaagaaaaagaagaa attccgcactccttcttttctgaaaaagaacaaaaaaaaggagaaagttgaggcctaaat aaagtctttttataattattattataacaatgtgacattgcacatctaaataccacattt aagttgatcattaatatgcaatggtagatcagattgggggatgtagcaaactggacttta agaac > 33113 a at HG-U95AV2 tttctccagtgctcaactgttagatattaatcttggcaaactgcttaatcttgtggattt nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagtgaaaggaaaaattgca ttagttggttgcatgaacttcngangggcagatattactgcacaaactgccatctcgctt catttttttaactatgncatttgagtancaganctaatttttaaaatatgctaaactgga anngattannnnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnntggctgtcccccccgccgccccccccacccccatatgtacagatgataat agggtgtggaatgtcgtcagtggcaaacatttcacagannnttattttgtttctgtcttc aacatttttgacactgtgctaatagttatattc > 33130 at HG-U95Av2 72- 98677.doc 200533758 cttgtaagccacttgtttggttatgatttgtgtcttatcagggaaaaggtgcccagctgc cagcccagctccgctgcntatctttgcctcacttagtca tgtgcaattcgcgttgcagag tggcagaccattagttgctgagnnnnnnnnnnnnnnnnntgtgctcagaagagcacctgc ccaaagtttttctggttttaatttaaaggacaaggctacatatattcagctttttgagat gaccaaagctagttagggtctccttgatgtagctaagctgcttcagtgatcttcacattt gcactccagttttttnnnnnnnnnnnnnnnnnnttctacctctctatgtgcctgagtgat gatacaatcgctgtttagttactagatgaacaaatccacagaatgggtaaagagtagaat ctgaactatatcttgacaaatattattcaaacttgaatgtaaatatatacagtatgtata ttttttaaaaagatttgcttgcaatgaccttata > 33235_at HG-U95Av2 gtgtcacaaagtcaataggtccttannnnnnnnnnnnnnnctaagggaaatccgaactga atttatgcacatagaattgtcaccctgactttgaagcctcaaacatggatcaaatctgtt gtgaaacatcaatatatgtagctggatgagtgactagtttcccttgtataatatgtgatc taagaaaattgctaatctttccctgccattttgagaaacacagtccaaacatgagcataa acagaatttcctgcaatacatncccagtaggtnccacctagtttacaacttaaactagtt tgtgaaacatttgtctgtatacattttatattttgtacattttgatgtaacatatcatgt aaataggcagaaacagtgaaataaatcatctgaaaagttttgtagtctttgtaaagcccc aacaataagtacttggtgtcaatggacttaactggatgatgtattttctattggtttatt

gttcctctagcttgtaaaccagcttgcatatatttttttgcaaatgtgcaccctgtatct gtctaaatt >33236_at HG-U95Av2 tgagcaacagtgcagaggtgaaacgggagcnnnnnnnnnnnnnnnngggaggctgttgct atcgggtcaacaacagcttggaccatgagtaccaaccacggcccgtggaggtgatcatca g11 c t gc ga ag ga gat ggtnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntggaaa aggccaaggttgaagtcggtgtggccacggcgcttggaatcctggttgttgctggatgct cttttgcgattaggagataccaaaaaaaagcgacagcctgaagcagccacaaaatcctgt gttagaagcagctgtgggggtcccagtggagatgagcctcccccatgcctccagcagcct gaccctcgtgccctgtctcaggcgttctctagatcctttcctctgtttccctctctcgct ggcaaaagtatgatctaattgaaacaagactgaaggatcaataaacagccatctgcccc >33243_at HG-U95Av2 tgcttctggaattgagttctccttttaagtaccaatgatacttaaatttctcagaaatgt aatggtgtgtcattgccttgaaatgcttgcttagggcttcttttatgttatcttaaaaag tgnnnnnnnnnnnnnnnttttttacatccatttcacatgtaagagacaaaaaagtctaga ttggtcttgatattgagataataaaaagtaagtagcattaagaaaggtaacaatncttca ttcnnnnnnnnnnnnnnnnntgaaacaatttaggggaatgaggggcaaaaggggagaaat actgctaaagaacatgagcataaaaatgcgtgcgtttcagtgtttaagaaggcttgataa agaatgtcacttttttatttaactgataagatttttgttattttttactttgataagtaa accaaagaatatttgtatttcaancagtttgtgtggtgtttctatataattttctgtgta taaataannnnnnnnnnnnnnnnnnnnnnnntaaaaaagnnnnnnnnnnnnnnnnnccag ctatgtcctctaggaaatgacag >33249_at HG-U95Av2 cacagcatgcagactgggagttgctagcaaacaaatggcttacntacnnaangcagcttt tagttcagacttagtttttataaaatgggaattnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnncagctttttgtattaacaaagttactggctctttgtgtgtctcca ggtaactnnnnnnnnnnnnnnnncaaagccatattctaaattcactgttgaatgcctgtc ccagtccaaattgtctgtctgctcttatttttgtaccatattgctcttaaaaatcttggt ttggtacagttcataattcaccaaaagttcatataatttaaanaaacactaaattagttt aaaatgaagcaatttatatctttatgcaaaaacatatgtctgtctttgcaaaggactgta agcagatt >33281_at HG-U95Av2 acccacaggaaagagtgtggcagcaactgcntggctgacctttctatcttctctaggctc aggtactgctcctccatgcccatggntgggncgtggggagaagaagctntcnnacgcctt cccactccctctggtttataggacttcactccctagccaacaggagaggaggcctcctng gggtttccccagggcagtaggtcaaacgacctcatcacagtcttccttcctcttcaagcg tnncatgttnaacacagntntnnccnntcccntgtgatttnnganggnnnncnnnnnnnn 73- 98677.doc 200533758 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnctatgcttggtctgactgagcctaaagt tgagaaaatgggtngccaaggccagtgccagtgtcttggggcccctttggctctccctca ctctctgaggctccagctggtcctgggacat >332 95__at HG-U95Av2 cagactgggtgcaggccaggtcccaggcctcaccctggggctcactgtgggaatttgggg ^gtggctgccctactgacactgcctgtcaccctggccagtggtgcttntggtggactctg caccctgatatacagcacggagctgaaggctttgcagnccacacacactgtagcctgtct tgccatctttgtcttgttgccattgggtttgtttggagccaaggggctnaagaaggcatt gggtatngggccaggcccctggatgaatatcctgtgggcctggtttattttctggtggcc tcatggggtggttctaggactggatttcctggtgaggtccaagctgttnnnnnnnnnnnn nnnt c t g gc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn t c tgccaccaggccacccgcaccct cttgccctctctgcccctccctgaaggatggtcttctcatctggacacccttggaagcaa atcctagttctcttcccacctgtcaacctgaattaaagtctacactgcctttg >33304_at HG-U95Av2 gttcatccggcctgagggagagatcaccgattacagaaccngggtcagcggggtcacccc tcagcacatggtgggggccacaccntttngccgtgnccaggctagagatcctgcagctccgttcctctagcttgtaaaccagcttgcatatatttttttgcaaatgtgcaccctgtatct gtctaaatt > 33236_at HG-U95Av2 tgagcaacagtgcagaggtgaaacgggagcnnnnnnnnnnnnnnnngggaggctgttgct atcgggtcaacaacagcttggaccatgagtaccaaccacggcccgtggaggtgatcatca g11 c t gc ga ag ga gat ggtnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntggaaa aggccaaggttgaagtcggtgtggccacggcgcttggaatcctggttgttgctggatgct cttttgcgattaggagataccaaaaaaaagcgacagcctgaagcagccacaaaatcctgt gttagaagcagctgtgggggtcccagtggagatgagcctcccccatgcctccagcagcct gaccctcgtgccctgtctcaggcgttctctagatcctttcctctgtttccctctctcgct ggcaaaagtatgatctaattgaaacaagactgaaggatcaataaacagccatctgcccc > 33243_at HG-U95Av2 tgcttctggaattgagttctccttttaagtaccaatgatacttaaatttctcagaaatgt aatggtgtgtcattgccttgaaatgcttgcttagggcttcttttatgttatcttaaaaag tgnnnnnnnnnnnnnnnttttttacatccatttcacatgtaagagacaaaaaagtctaga ttggtcttgatattgagataataaaaagtaagtagcattaagaaaggtaacaatncttca ttcnnnnnnnnnnnnnnnnntgaaacaatttaggggaatgaggggcaaaaggggagaaat actgctaaagaacatgagcata aaaatgcgtgcgtttcagtgtttaagaaggcttgataa agaatgtcacttttttatttaactgataagatttttgttattttttactttgataagtaa accaaagaatatttgtatttcaancagtttgtgtggtgtttctatataattttctgtgta taaataannnnnnnnnnnnnnnnnnnnnnnntaaaaaagnnnnnnnnnnnnnnnnnccag ctatgtcctctaggaaatgacag > 33249_at HG-U95Av2 cacagcatgcagactgggagttgctagcaaacaaatggcttacntacnnaangcagcttt tagttcagacttagtttttataaaatgggaattnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnncagctttttgtattaacaaagttactggctctttgtgtgtctcca ggtaactnnnnnnnnnnnnnnnncaaagccatattctaaattcactgttgaatgcctgtc ccagtccaaattgtctgtctgctcttatttttgtaccatattgctcttaaaaatcttggt ttggtacagttcataattcaccaaaagttcatataatttaaanaaacactaaattagttt aaaatgaagcaatttatatctttatgcaaaaacatatgtctgtctttgcaaaggactgta agcagatt > 33281_at HG-U95Av2 acccacaggaaagagtgtggcagcaactgcntggctgacctttctatcttctctaggctc aggtactgctcctccatgcccatggntgggncgtggggagaagaagctntcnnacgcctt cccactccctctggtttataggacttcactccctagccaacaggagaggaggcctcctng gggtttccccagggcagtaggtcaaacgacctcatcacagtcttccttcctcttcaagcg tnncatgttnaacacagntntnnccnnt cccntgtgatttnnganggnnnncnnnnnnnn 73- 98677.doc 200533758 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnctatgcttggtctgactgagcctaaagt tgagaaaatgggtngccaaggccagtgccagtgtcttggggcccctttggctctccctca ctctctgaggctccagctggtcctgggacat > 332 95__at HG-U95Av2 cagactgggtgcaggccaggtcccaggcctcaccctggggctcactgtgggaatttgggg ^ gtggctgccctactgacactgcctgtcaccctggccagtggtgcttntggtggactctg caccctgatatacagcacggagctgaaggctttgcagnccacacacactgtagcctgtct tgccatctttgtcttgttgccattgggtttgtttggagccaaggggctnaagaaggcatt gggtatngggccaggcccctggatgaatatcctgtgggcctggtttattttctggtggcc tcatggggtggttctaggactggatttcctggtgaggtccaagctgttnnnnnnnnnnnn nnnt c t g gc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn t c tgccaccaggccacccgcaccct cttgccctctctgcccctccctgaaggatggtcttctcatctggacacccttggaagcaa atcctagttctcttcccacctgtcaacctgaattaaagtctacactgcctttg > 33304_at HG-U95Av2 gttcatccggcctgagggagagatcaccgattacagaaccngggtcagcggggtcacccc tcagcacatggtgggggccacaccntttngccgtgnccaggctagagatcctgcagctcc

tgaaaggcaagctggtggtgggtcatgacctgaagcacgacttnnnnnnnnnnnnnnnnn acatgagcggctacacaatctacgacacgtccactnnnnnnnnnnnnnnnngtgaggcca agctggaccactgcaggcgtgtctccctgcgggtgctgagtgagcgcctcctgcacaaga gcatccagaacagcctgcttggacacagcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nctatcaaatctcccagagaatccgagcccgccgagggctgccccgcctggctgtgtcag actgaagccccatccagcccgttccgcagggactagaggctttcggctttttgggacagc aactaccttgcttttgga >33331_at HG-U95Av2 gaaggacccatgtcccaggaaccgcgntgcgccacctgcactcacccccctcacattctc ttaagcacccggtngccctccgaggcctggcggaatggtggtgcccacggggttgggcaa gggctcaccaggacctcaacgggcaaagttgtgcacactaaaatatcaaatcaaggtgct tggttttaaagtaaatgtttttctaaagaaagctgtgntcttctgttgacccagacgaat anngcacagccctgtaactgcacgtgccttctgtcattgggaatgaaataaattattacg agaaaggganttgtcctaannngtttgaggccttacagttttgtatctacatttttcccc tcctggggtttgcggggacagggacagaactacaggagtcatgggaaagaaaattctggc ttcactactgctcactgctcactttctgatcactctganacnnntttttttttttttttt ttgcaacctgataccttgaaaag >33371_s_at HG-U95Av2 cgacctctcagatattagggaggttcccctgaaggatgctaaggaatacgctgaatccat aggtgccatcgtggttgagacaagtgcaaaaaatgctattaatatcgaagagctctttca aggaatcagccgccagatcccacccttggacccccatgaaaatggaaacaatggaacaat caaagttgagaagccaaccatgcaanccagccgccggtgctgttgacccaagggcngtgg tccacgntacttgaagaagccagagcccacatcctgtgcactgctgaaggaccctacgct cggtggcctggcacctcactttgagaagagtgagcacactggctttgcatcctggaagnc ctgcaggggnnngggcaggaaatgtacctgaaaaggattttagaaaaccctggnaaaccc accacaccaccnnnacaaaatggcctttagtgtatgaaatgcac >33410_at HG-U95Av2 agtgactgtgtttccctcaaagactgtagctcagtattcgggagtaccttggtggatcat cctagtggc >33411_g_at HG-U95Av2 ctgtagcgtgaacgtgaactgtgtgaacatcagatgcccgctgcgggggctggacagcaa ggcgtctcttattttgcgctcgaggttatggaacagcacatttctagaggaatattccaa actgaactacttg >33439_at HG-U95Av2 gaccaggtgccttgccgcagagaaaancnaccaaagtctcctgttcgctcataaagaagt ttttgggatgggagagannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntt tttacagaggnnnnnnnnnnnnnnnnncaacacaaaacnncttcccctttttaaaatgat -74 - 98677.doc 200533758 ttctgttctaatgccatagatcaaaggcctcagaaaccattgtgtgtttcctctttgaag caatgacaagcactttactttcacggtggtttttgttttttcttattgctgtggaacctc ttttggaggacgttaaaggcgtgttttacttgtttttttaagagtgtgtgatgtgtgttt tgtagatttcttgacagtnnnnnnnnnnnnnnnnnnnnnnnnnngcctatttaaagacnc tacgtgatctgattgagatgtaca >33533一at HG-U95AV2 aatagtattccagcagacattgtttttdtcattaaagacaaagatcatccaaeiatttaaa agggatggatcaaatataatttactgctaaaattagtttacgagaggagattgtgtggcg tgctcaattaatgtaccaacactggatggaagaacatacctatgtcagtaaatgatattg tgaancccggaatgaggagaagaattattggatatgggctgccatttccaaaaaatnnnn nnnnnnnnnnnnnnnnnnnnnnnnnntttgaggtgtccttcccagatactatatcttctt catnnaaagaagtactnnnnnnnnnnnnnnnnnnnnnnnagaatgannnacttnnntana natattttgataaggcactgaaaatataaaaggantggtagtttactgatgtagatgtga attctgtataaagatgtgtaaattnttttgagggttcattaaattgcatgaatagagaca ggtcaaataaataggcaaaagggatttttacagttagagatagaagagaaaaccattcac tgtattt >33707_at HG-U95Av2tgaaaggcaagctggtggtgggtcatgacctgaagcacgacttnnnnnnnnnnnnnnnnn acatgagcggctacacaatctacgacacgtccactnnnnnnnnnnnnnnnngtgaggcca agctggaccactgcaggcgtgtctccctgcgggtgctgagtgagcgcctcctgcacaaga gcatccagaacagcctgcttggacacagcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nctatcaaatctcccagagaatccgagcccgccgagggctgccccgcctggctgtgtcag actgaagccccatccagcccgttccgcagggactagaggctttcggctttttgggacagc aactaccttgcttttgga > 33331_at HG-U95Av2 gaaggacccatgtcccaggaaccgcgntgcgccacctgcactcacccccctcacattctc ttaagcacccggtngccctccgaggcctggcggaatggtggtgcccacggggttgggcaa gggctcaccaggacctcaacgggcaaagttgtgcacactaaaatatcaaatcaaggtgct tggttttaaagtaaatgtttttctaaagaaagctgtgntcttctgttgacccagacgaat anngcacagccctgtaactgcacgtgccttctgtcattgggaatgaaataaattattacg agaaaggganttgtcctaannngtttgaggccttacagttttgtatctacatttttcccc tcctggggtttgcggggacagggacagaactacaggagtcatgggaaagaaaattctggc ttcactactgctcactgctcactttctgatcactctganacnnntttttttttttttttt ttgcaacctgataccttgaaaag > 33371_s_at HG-U95Av2 cgacctctcagatattagggaggttcccctgaaggatgctaaggaatacgctgaa tccat aggtgccatcgtggttgagacaagtgcaaaaaatgctattaatatcgaagagctctttca aggaatcagccgccagatcccacccttggacccccatgaaaatggaaacaatggaacaat caaagttgagaagccaaccatgcaanccagccgccggtgctgttgacccaagggcngtgg tccacgntacttgaagaagccagagcccacatcctgtgcactgctgaaggaccctacgct cggtggcctggcacctcactttgagaagagtgagcacactggctttgcatcctggaagnc ctgcaggggnnngggcaggaaatgtacctgaaaaggattttagaaaaccctggnaaaccc accacaccaccnnnacaaaatggcctttagtgtatgaaatgcac > 33410_at HG-U95Av2 agtgactgtgtttccctcaaagactgtagctcagtattcgggagtaccttggtggatcat cctagtggc > 33411_g_at HG-U95Av2 ctgtagcgtgaacgtgaactgtgtgaacatcagatgcccgctgcgggggctggacagcaa ggcgtctcttattttgcgctcgaggttatggaacagcacatttctagaggaatattccaa actgaactacttg > 33439_at HG-U95Av2 gaccaggtgccttgccgcagagaaaancnaccaaagtctcctgttcgctcataaagaagt ttttgggatgggagagannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntt tttacagaggnnnnnnnnnnnnnnnnncaacacaaaacnncttcccctttttaaaatgat -74 - 98677.doc 200533758 ttctgttctaatgccatagatcaaaggcctcagaaaccattgtgtgtttcctctttgaag caatgacaagcactttactttcacggtggtttttg ttttttcttattgctgtggaacctc ttttggaggacgttaaaggcgtgttttacttgtttttttaagagtgtgtgatgtgtgttt tgtagatttcttgacagtnnnnnnnnnnnnnnnnnnnnnnnnnngcctatttaaagacnc tacgtgatctgattgagatgtaca > 33533 a at HG-U95AV2 aatagtattccagcagacattgtttttdtcattaaagacaaagatcatccaaeiatttaaa agggatggatcaaatataatttactgctaaaattagtttacgagaggagattgtgtggcg tgctcaattaatgtaccaacactggatggaagaacatacctatgtcagtaaatgatattg tgaancccggaatgaggagaagaattattggatatgggctgccatttccaaaaaatnnnn nnnnnnnnnnnnnnnnnnnnnnnnnntttgaggtgtccttcccagatactatatcttctt catnnaaagaagtactnnnnnnnnnnnnnnnnnnnnnnnagaatgannnacttnnntana natattttgataaggcactgaaaatataaaaggantggtagtttactgatgtagatgtga attctgtataaagatgtgtaaattnttttgagggttcattaaattgcatgaatagagaca ggtcaaataaataggcaaaagggatttttacagttagagatagaagagaaaaccattcac tgtattt > 33707_at HG-U95Av2

cgtggccgggctctactacccgaagnatagtgcccgaagttgctgcttggcatagatgag cctcagcttccagggcactgtgggcntgttggtctactagggccctgangtccacctggc cttcctgttcttcactcccttcagccacacgcttcatggccttgagtnnnnnnnnnnnnn nnnnnnnnnnccaatcaccagtgaccagetagactgtgattttgatagegtcattcagaa gaaggcgtccaaggagctgaaggtggtgaaatttgtcctgcaggtccctcgggagatcct ggagctggagcatgagtgtctgacaatcagaagcatcatgtccaatgtccagatggccag aatgaatgtgatagttcagaccaatgccttccactgctcctttatgactgcacttctagc cagtagctctgcacaagttagctctgtaga >33731_at HG-U95Av2 ctgtgtatgtcagttgctgcagaaatggatttggaagatggaggagagatgcccaagcaa cgggatcccaantctaacnaaacaccatctggaatcctgatgtggaaagcaggggtttct ggtctactggctagagctaaggaagttgaaaaggaaagctcacttctttggaggcacctg tccagaagcctggcctaggcagcttcaacctttgaacttactttttgaaatgaaaagtaa tttatttgttttgctacatactgttccagacttttaaaggggacaatgaaggtgactgtg gggaggagcatgtcaggtttgggcttggttgttttagaagcacctgggtgtgcctaccta ctcctcttttcttttaaaagggcccacaatgctccaatttcctgtctcctttagagagac atgaaact >33764_at HG-U95Av2 gtgtattaccagtatttacttgctttcttgatttcaccaaaaccaaatttaatttaaagg accacattaatttttcaaagggaaagagacaattaattgtacataatgtatacacacaca naaaaaaaaatacctgtagaaatattattccagcatagcnggaaaacaaacaaaagtatt ggactgtcggaggtgagcctgtgcgtctgtaaccctttgtgactcctgagcgtgcgctgt cttnctaggttaactcacgaagtacattctctgtcttactgatactgtaggttcacccat ttttttttaatttcctcgcaaataacaagacc nnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnttcttttatatgcagcaaacacaccgtccatttctgaagaggcttcggcntgaag gcattttccaatgatgttagtgcacaaaacgctttaaattagactggaactgccagaatc aaatgtaaatgaggaatttctcgtacccctactgcatggtatcgattttta >33772一at HG-U95AV2 ttgcttccaggtgtgcctggcatgggcctggcccaggaagacaccacctcactgaggact ttgcgaatatcagagacctcagactcttcacagggtcaggactcagagagtgtcttactg gtggatgaggctggtgggagcggcagggctgggcctgcccntaaggggagctccctgcaa gtcacatttcccagtgaaacactgaacttatcagaaaaatgtatataataggcaaggaaa gaaatacagtactgtttctggacccttataaaatcctgtgcaatagacacatacatgtca catttagctgtgctcagaagggctatcatcatcctacaactcacattagagaacatcctg g >33790_at HG-U95Av2 cccacagcatgaagatctccgtggctgccattcccttcttcctcctcatcaccatcgccc tagggaccaagactgaatcctcctcacggggaccttaccacccctcagagtgctgcttca 75- 98677.doc 200533758 cctacactacctacaagatcccgcnnnnnnnnnnnnnnnnnnntactatgagannnnnnn nnnnnnnnnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn rmnrmimmmmmrmrmnrmnmmnnrmrmnmmrmrmmmrmmma g aac t g ag t ga c c cagaaggggtggcgaaggcacagctcagagacataaagagaagatgccaaggccccctcc tccacccaccgctaactctcagccccagtcaccctcttggagcttccctgctttgaatta aagacc >33791_at HG-U95Av2 agaatatctagcatgtaaggcctttcaatattaatataagcccaatatcagctctttctc tttgtatttcatctctttctactctcctatttgtattttgtgttcctatcaaagtgtcgt atctgggag >33802_at HG-U95Av2 ttctttctagagagggaattctcttggctggnttccttaccnnnnnnnnnnnnnnnnntn nngggcctccagccctctcactgtgtccctctctctggaaaggaggaaggagcctatggc atcttccccaacgaaaagcacatccaggcaatggcctaaacttcagagggggcgaaggga tcagccctgcccttcagcatcctcagttcctgcagcagagcctggaagacaccctaatgt ggcagctgtctcaaacctccaaaagccctgagtttcaagtatccttgttgacacggccat gaccactttccccgtgggccatggcaatttttacacaaacctgaaaagatgttgtgtcttcgtggccgggctctactacccgaagnatagtgcccgaagttgctgcttggcatagatgag cctcagcttccagggcactgtgggcntgttggtctactagggccctgangtccacctggc cttcctgttcttcactcccttcagccacacgcttcatggccttgagtnnnnnnnnnnnnn nnnnnnnnnnccaatcaccagtgaccagetagactgtgattttgatagegtcattcagaa gaaggcgtccaaggagctgaaggtggtgaaatttgtcctgcaggtccctcgggagatcct ggagctggagcatgagtgtctgacaatcagaagcatcatgtccaatgtccagatggccag aatgaatgtgatagttcagaccaatgccttccactgctcctttatgactgcacttctagc cagtagctctgcacaagttagctctgtaga > 33731_at HG-U95Av2 ctgtgtatgtcagttgctgcagaaatggatttggaagatggaggagagatgcccaagcaa cgggatcccaantctaacnaaacaccatctggaatcctgatgtggaaagcaggggtttct ggtctactggctagagctaaggaagttgaaaaggaaagctcacttctttggaggcacctg tccagaagcctggcctaggcagcttcaacctttgaacttactttttgaaatgaaaagtaa tttatttgttttgctacatactgttccagacttttaaaggggacaatgaaggtgactgtg gggaggagcatgtcaggtttgggcttggttgttttagaagcacctgggtgtgcctaccta ctcctcttttcttttaaaagggcccacaatgctccaatttcctgtctcctttagagagac atgaaact > 33764_at HG-U95Av2 gtgtattaccagtatttacttgctttcttgatttcaccaaaaccaaatttaatttaaagg accacattaatttttcaaagggaaagagacaattaattgtacataatgtatacacacaca naaaaaaaaatacctgtagaaatattattccagcatagcnggaaaacaaacaaaagtatt ggactgtcggaggtgagcctgtgcgtctgtaaccctttgtgactcctgagcgtgcgctgt cttnctaggttaactcacgaagtacattctctgtcttactgatactgtaggttcacccat ttttttttaatttcctcgcaaataacaagacc nnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnttcttttatatgcagcaaacacaccgtccatttctgaagaggcttcggcntgaag gcattttccaatgatgttagtgcacaaaacgctttaaattagactggaactgccagaatc aaatgtaaatgaggaatttctcgtacccctactgcatggtatcgattttta > 33772 a at HG-U95AV2 ttgcttccaggtgtgcctggcatgggcctggcccaggaagacaccacctcactgaggact ttgcgaatatcagagacctcagactcttcacagggtcaggactcagagagtgtcttactg gtggatgaggctggtgggagcggcagggctgggcctgcccntaaggggagctccctgcaa gtcacatttcccagtgaaacactgaacttatcagaaaaatgtatataataggcaaggaaa gaaatacagtactgtttctggacccttataaaatcctgtgcaatagacacatacatgtca catttagctgtgctcagaagggctatcatcatcctacaactcacattagagaacatcctg g > 33790_at HG-U95Av2 cccacagcatgaagatctccgtggctgccattcccttcttcctcctcatcaccatcgccc tagggaccaagactgaatcctcctcacggggaccttaccacc cctcagagtgctgcttca 75- 98677.doc 200533758 cctacactacctacaagatcccgcnnnnnnnnnnnnnnnnnnntactatgagannnnnnn nnnnnnnnnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn rmnrmimmmmmrmrmnrmnmmnnrmrmnmmrmrmmmrmmma g aac t g ag t ga c c cagaaggggtggcgaaggcacagctcagagacataaagagaagatgccaaggccccctcc tccacccaccgctaactctcagccccagtcaccctcttggagcttccctgctttgaatta aagacc > 33791_at HG-U95Av2 agaatatctagcatgtaaggcctttcaatattaatataagcccaatatcagctctttctc tttgtatttcatctctttctactctcctatttgtattttgtgttcctatcaaagtgtcgt atctgggag > 33802_at HG-U95Av2 ttctttctagagagggaattctcttggctggnttccttaccnnnnnnnnnnnnnnnnntn nngggcctccagccctctcactgtgtccctctctctggaaaggaggaaggagcctatggc atcttccccaacgaaaagcacatccaggcaatggcctaaacttcagagggggcgaaggga tcagccctgcccttcagcatcctcagttcctgcagcagagcctggaagacaccctaatgt ggcagctgtctcaaacctccaaaagccctgagtttcaagtatccttgttgacacggccat gaccactttccccgtgggccatggcaatttttacacaaacctgaaaagatgttgtgtctt

gtgtttttgtcttatttttgttggagccactctgttcctngctcagcctcaaatgcagta tttttgttgtgttctgttgtttttatagcagggttggggtggtttttgagccatgcgtgg gtggggagggaggtgtttaacggcactgtggccttgg >33803_at HG-U95Av2 tttctaccatttcagagaggccttttggaatgtggcccctgaacaagaattggaagctgc cctgcccatgggagctggttagaaatgcagaatcctaggctccaccccatccagttcatg agaatctatatttaacaagatctgcagggggtgtgtctgctcagtaatttgaggacaacc attccnagactgcttccaattttctggaatacatgaaatatagatcagttataagtagca ggccaagtcaggcccttattttcaagaaactgaggaattttctttgtgtagctttgctct ttggtagaaaaggctaggtacacagctctagacactgccacacagggtctgcaaggtctt tggttcagctaagctaggaatgaaatcctgcttcagtgtatggaaataaatgtatcatag aaatgtaacttttgtaagacaaaggttttcctcttctattttgtaaactcaaaatatttg tacatagttatttatttattggagataatctagaacacaggcaaaatc >33849一at HG-U95Av2 tcttactggaatgtctaggcactgtacagttattatatatcttggttgttgtattgtacc agtgaaatgccaaatttgaaaggcctgtactgcaattttatatgtcagagattgcctgtg gctctaatatgcacctcaagattttaaggagataatgtttttagagagaatttctgcttc cactatagaatatatacataaatgtaaaatacttacaaaagtggaagtagtgtattttaa agtaattacacttctgaatttatttttcatattctatagttggtatgacttaaatgaatt actggagtgggtagtgagtgtacttaaatgtttcaattctgttatattttttattaagtt tttaaaaaattaaattggatattaaattgtannnanannannnantaattttaaactgaa tgccctcaataagtaatactgaagnnnnttcttaaatgaagataaattatctccaatgaa aagcatgacatgtgtttcaatagaagaatcttaagttggctaaattcaaagtgcttgaca tcaaaatgttctngagtgattagctactagattctgaatcatacatcacatctgactaga gaccag >33862_at HG-U95Av2 tcacttggcgaggagcccgcctgctccggcccctcctgcagttcaccttgatcatgatgg ccttctacacgggactgtctcgcgtatcagaccacaagcaccatcccagtgatgttctgg caggatttgctcaaggagccctggtggcctgctgcatagttttcttcgtgtctgacctct tcaagactaagacgacgctctccctgcctgcccctgctatccggaaggaaatcctttcac ctgtggacattattgacaggaacaatcaccacaacatgatgtaggtgccacccacctcct gagctgtttttgtaaaatgactgctgacagcaagttcttgctgctctccaatctcatcag acagtagaatgtagggaaaaacttttgcccgactgatttttaaaaannaaaaaaaaaatg ttttactatgtggccttcca >33900_at HG-U95Av2 tgtgacatccggagtcctggagccgggtgtnccagtggnancactaggtnnntgctgnct ncnnnnnnngnnnnnnncncannnnnnnntnnttngtcccccacaacctgccccggnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 76- 98677.doc 200533758 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnttctcccacgacggctcaccctcccctccat ctgcgttgatgctcagaatcgcctacctgtgcctgcgtgtaaaccacagcctcagaccag ctatggggagaggacaacnnnnnnnnnnnnnnnnnnnnncggtctggggtgaggagtgtg gggagcttgggcatcctcctccagcctcctccagcccnnnnnnnnnnnnnnncctgtggt gcccagaaaagtgcccctaggttggtgggtctacaggagcctcagccaggcagcccaccc caccctggggccctgcctcaccaaggaaataaagactc >33925__at HG-U95Av2 ttggtttcggacgacccttgctctgaccggaagagaagtccctatcccacacctgcctgt cacgttccctcccctttccccagcgcactgttgagggcagcctctccagctctcttgttt atgcaaacgccgagcgcctgggaggctcggtaggaggagtcttccacggccccgccccgn ccctgtcggtcccgccctnccccccgccgggctcctggggctgtggccgaaaggtttctg atctcc.gtgtgtgcatgtgactgtgctgggttggaatgtgaacaataaagaggaatgtcc aagtgnnnaaaaaaaaaaaaannagggagtttgggtgcacaaggcctccgc >33943_at HG-U95Av2 gtgaccacgtgaccaacttgcgcaagatgggannnnnnnnnnnnnnnnnnnnnnnnnnnn nnnttgacaagcacaccctgggagacagtgataatgaaagctaagcctcgggctaatttc ccnatagccgtggggtgacttccntggtcaccaaggcagtgcatgcatgttggggtttccgtgtttttgtcttatttttgttggagccactctgttcctngctcagcctcaaatgcagta tttttgttgtgttctgttgtttttatagcagggttggggtggtttttgagccatgcgtgg gtggggagggaggtgtttaacggcactgtggccttgg > 33803_at HG-U95Av2 tttctaccatttcagagaggccttttggaatgtggcccctgaacaagaattggaagctgc cctgcccatgggagctggttagaaatgcagaatcctaggctccaccccatccagttcatg agaatctatatttaacaagatctgcagggggtgtgtctgctcagtaatttgaggacaacc attccnagactgcttccaattttctggaatacatgaaatatagatcagttataagtagca ggccaagtcaggcccttattttcaagaaactgaggaattttctttgtgtagctttgctct ttggtagaaaaggctaggtacacagctctagacactgccacacagggtctgcaaggtctt tggttcagctaagctaggaatgaaatcctgcttcagtgtatggaaataaatgtatcatag aaatgtaacttttgtaagacaaaggttttcctcttctattttgtaaactcaaaatatttg tacatagttatttatttattggagataatctagaacacaggcaaaatc > 33849 a at HG-U95Av2 tcttactggaatgtctaggcactgtacagttattatatatcttggttgttgtattgtacc agtgaaatgccaaatttgaaaggcctgtactgcaattttatatgtcagagattgcctgtg gctctaatatgcacctcaagattttaaggagataatgtttttagagagaatttctgcttc cactatagaatatatacataaatgtaaaatacttacaaaagtggaagtagtgtattttaa agtaattacac ttctgaatttatttttcatattctatagttggtatgacttaaatgaatt actggagtgggtagtgagtgtacttaaatgtttcaattctgttatattttttattaagtt tttaaaaaattaaattggatattaaattgtannnanannannnantaattttaaactgaa tgccctcaataagtaatactgaagnnnnttcttaaatgaagataaattatctccaatgaa aagcatgacatgtgtttcaatagaagaatcttaagttggctaaattcaaagtgcttgaca tcaaaatgttctngagtgattagctactagattctgaatcatacatcacatctgactaga gaccag > 33862_at HG-U95Av2 tcacttggcgaggagcccgcctgctccggcccctcctgcagttcaccttgatcatgatgg ccttctacacgggactgtctcgcgtatcagaccacaagcaccatcccagtgatgttctgg caggatttgctcaaggagccctggtggcctgctgcatagttttcttcgtgtctgacctct tcaagactaagacgacgctctccctgcctgcccctgctatccggaaggaaatcctttcac ctgtggacattattgacaggaacaatcaccacaacatgatgtaggtgccacccacctcct gagctgtttttgtaaaatgactgctgacagcaagttcttgctgctctccaatctcatcag acagtagaatgtagggaaaaacttttgcccgactgatttttaaaaannaaaaaaaaaatg ttttactatgtggccttcca > 33900_at HG-U95Av2 tgtgacatccggagtcctggagccgggtgtnccagtggnancactaggtnnntgctgnct ncnnnnnnngnnnnnnncncannnnnnnntnnttngtcccccacaacctgccccggnnnn nnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 76- 98677.doc 200533758 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnttctcccacgacggctcaccctcccctccat ctgcgttgatgctcagaatcgcctacctgtgcctgcgtgtaaaccacagcctcagaccag ctatggggagaggacaacnnnnnnnnnnnnnnnnnnnnncggtctggggtgaggagtgtg gggagcttgggcatcctcctccagcctcctccagcccnnnnnnnnnnnnnnncctgtggt gcccagaaaagtgcccctaggttggtgggtctacaggagcctcagccaggcagcccaccc caccctggggccctgcctcaccaaggaaataaagactc > 33925__at HG-U95Av2 ttggtttcggacgacccttgctctgaccggaagagaagtccctatcccacacctgcctgt cacgttccctcccctttccccagcgcactgttgagggcagcctctccagctctcttgttt atgcaaacgccgagcgcctgggaggctcggtaggaggagtcttccacggccccgccccgn ccctgtcggtcccgccctnccccccgccgggctcctggggctgtggccgaaaggtttctg atctcc.gtgtgtgcatgtgactgtgctgggttggaatgtgaacaataaagaggaatgtcc aagtgnnnaaaaaaaaaaaaannagggagtttgggtgcacaaggcctccgc > 33943_at HG-U95Av2 gtgaccacgtgaccaacttgcgcaagatgggannnnnnnnnnnnnnnnnnnnnnnnnnnn nnnttgacaagcacaccctgggagacagtgataatgaaagctaagcctcgggctaatttc ccnatagccgtggggtgacttccntggtcaccaaggcagtgcatgcatgttggggtttcc

tttaccttttctataagttgtaccaaaacatccacttaagttctttgatttgtaccattc ttcaaataaagaaatttggtacccaggtgttgtctttgaggtcttggatgaatcagaaat ctatccaggctatcttccagattccttaag >34022_at HG-U95Av2 gtatcattgacacttcctgcagggtggtccctngccctnacnaganctgaaantgaaaan gagancagcagctttctagggacagctggaaanggacttaatgtgtttgactatttctta cgagggttctacttatttatgtatttatttttgaaagcttgtattttaatattttacatg ctgttatttaaagatgtgagtgtgtttcatcaaacatagctcagtcctgattatttaatt ggaatatgatgggttttaaatgtgtcattaaactaatatttagtgggagaccataatgtg tcagccaccttgataaatgacagggtggggaactggagggtggggggattgaaatgcaag caattagtggatcactgttagggtaagggaatgtatgtacacatctattttttatacttt ttttttaaaaaaagaatgtcagttgttatttattcaaattatctcacattatgtgttcaa catttttatgctgaagtttcccttagacattttatgtcttgcttgtagggcataatgcct tgtttaatgtccattctgcagcgtttctc >34075一at HG-U95AV2 aggacaacgactaccaccgcagcgacgagcaggtgagcannnnnnnnnnnnnnnnnnnnn nnnnnnnnnncgggctgaagcggaagtggatccgctgctcagcccaggcgaccgtcttgc atctgaagaagttcatcgccaaaaaactcaacctttcatcctttaacgagctggacattt tatgcaacgaggagatcctgggcaaggaccacacactcaagttcgtggttgtcactaggt ggagattcaagaaggcgccgctcctgctgcactacagacccaagatggacttgctgtgaa tggtgccacacagcgcccacagactgggcnntcgcacccttggntnntcccggccgncgc gcttaagaacattgcctctgggtgtcatgtggaccagacttctgaataga >34082_at HG-U95Av2 . actctgtgcccgaatggtggtgcaggcgccctgtcctggttgtgttgttacgtgtttgac cagcacaggggtccggtggggaaaatgtatgggttnntntcagttgttgctantnctgan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnat gattgtgtttaggtttgaaattgctcaagtgtctggctcaggtggtggttctgagacnnn nnnnnnnnnnnngagcccagatgcttaggtccactagggcccatctagggaagggaaagg agatttcagcggnttccccgaaaggaacaggactgtcgggatgcttcccggatgtctaca gttgccccttcctgcagtgagattactgcttcctgtttccctccagctcttcccagcagc agtgagggagtattaagagggatcttgtagtcgctgcctggctcttgtgggcggcccttt aagactcaggttgagetcagecaagtcccgcttgcgccaggntttgattcaaggtngtca gnaagttagattgtcaaaacatttcgagagagaggcag >34209_at HG-U95Av2 agatccggcctcaggacttacacctcctgcctgacccccaggcttctctctcctttctcc cagcaaactgcagtggcagaaaggaggttcagaggctgggaaagtgggcctccccttgca actcagagctgctgcactcaggagggccccatccaatcccgggcccctgcagggaaaagc gctgggtgtgtgtcanaggcgcagggtgggtggggctgccagccaggaccctggcctgca 77- 98677.doc 200533758 gcctgatccaaaccaaagactgtagaaccctggggtgtggctaacggcccctccagcacc catagccaggtcttcctggcccttgaggctgggctggcggacaggcacctacc >34232_at HG-U95Av2 atatggcaacggaacatcctcaagcagaggtagtaaaacaggnnnnnnnnnnnnnnnaaa gtaaagtgttgggtgaagtggggaaacaggacagcagctctgctagcttggctagnnnnn nnnnnnnnnncgggaagaaggaggtggctgagaagagccagatcaacctcattgataaga aatggaagcccctgcaaggtgtggggaacctggcagnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaatgaaaccacaaggcttgagaatag aaattaaaagcaaaaataaagttcggcctgggtctctctttgatgaagtaagaaagacag cacgcttaaaccgtagaccaagaaatcaggagagttcaagtgatgagcagacgcctagtc gggatgatgatagccagtccaggagtccaagtagatctcgaagtaaatctgaaaccaaat caagacacagaacaaggtctgtctcctatagtcactcaagaagtcgatc >342 61__at HG-U95Av2 ctctaactggcctggctctggaagggctggtgaggactctgcctccttgcctgcctacaa ggtgcctggtttgcagcaggctctccgctctttccagcaaagctgctcagagagggtgtc cagcacagtggagaggccggaagtgagacgggcagacggcacctgcagcctgaaacgcac cgctcctgcgtgcgcccccacctggtccccggatgcccccaccacctggacagaggccactttaccttttctataagttgtaccaaaacatccacttaagttctttgatttgtaccattc ttcaaataaagaaatttggtacccaggtgttgtctttgaggtcttggatgaatcagaaat ctatccaggctatcttccagattccttaag > 34022_at HG-U95Av2 gtatcattgacacttcctgcagggtggtccctngccctnacnaganctgaaantgaaaan gagancagcagctttctagggacagctggaaanggacttaatgtgtttgactatttctta cgagggttctacttatttatgtatttatttttgaaagcttgtattttaatattttacatg ctgttatttaaagatgtgagtgtgtttcatcaaacatagctcagtcctgattatttaatt ggaatatgatgggttttaaatgtgtcattaaactaatatttagtgggagaccataatgtg tcagccaccttgataaatgacagggtggggaactggagggtggggggattgaaatgcaag caattagtggatcactgttagggtaagggaatgtatgtacacatctattttttatacttt ttttttaaaaaaagaatgtcagttgttatttattcaaattatctcacattatgtgttcaa catttttatgctgaagtttcccttagacattttatgtcttgcttgtagggcataatgcct tgtttaatgtccattctgcagcgtttctc > 34075 a at HG-U95AV2 aggacaacgactaccaccgcagcgacgagcaggtgagcannnnnnnnnnnnnnnnnnnnn nnnnnnnnnncgggctgaagcggaagtggatccgctgctcagcccaggcgaccgtcttgc atctgaagaagttcatcgccaaaaaactcaacctttcatcctttaacgagctggacattt tatgcaacgaggagatcctgggcaaggaccacacact caagttcgtggttgtcactaggt ggagattcaagaaggcgccgctcctgctgcactacagacccaagatggacttgctgtgaa tggtgccacacagcgcccacagactgggcnntcgcacccttggntnntcccggccgncgc gcttaagaacattgcctctgggtgtcatgtggaccagacttctgaataga >. 34082_at HG-U95Av2 actctgtgcccgaatggtggtgcaggcgccctgtcctggttgtgttgttacgtgtttgac cagcacaggggtccggtggggaaaatgtatgggttnntntcagttgttgctantnctgan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnat gattgtgtttaggtttgaaattgctcaagtgtctggctcaggtggtggttctgagacnnn nnnnnnnnnnnngagcccagatgcttaggtccactagggcccatctagggaagggaaagg agatttcagcggnttccccgaaaggaacaggactgtcgggatgcttcccggatgtctaca gttgccccttcctgcagtgagattactgcttcctgtttccctccagctcttcccagcagc agtgagggagtattaagagggatcttgtagtcgctgcctggctcttgtgggcggcccttt aagactcaggttgagetcagecaagtcccgcttgcgccaggntttgattcaaggtngtca gnaagttagattgtcaaaacatttcgagagagaggcag > 34209_at HG-U95Av2 agatccggcctcaggacttacacctcctgcctgacccccaggcttctctctcctttctcc cagcaaactgcagtggcagaaaggaggttcagaggctgggaaagtgggcctccccttgca actcagagctgctgcactcaggagggccccatccaatcccgggcc cctgcagggaaaagc gctgggtgtgtgtcanaggcgcagggtgggtggggctgccagccaggaccctggcctgca 77- 98677.doc 200533758 gcctgatccaaaccaaagactgtagaaccctggggtgtggctaacggcccctccagcacc catagccaggtcttcctggcccttgaggctgggctggcggacaggcacctacc > 34232_at HG-U95Av2 atatggcaacggaacatcctcaagcagaggtagtaaaacaggnnnnnnnnnnnnnnnaaa gtaaagtgttgggtgaagtggggaaacaggacagcagctctgctagcttggctagnnnnn nnnnnnnnnncgggaagaaggaggtggctgagaagagccagatcaacctcattgataaga aatggaagcccctgcaaggtgtggggaacctggcagnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaatgaaaccacaaggcttgagaatag aaattaaaagcaaaaataaagttcggcctgggtctctctttgatgaagtaagaaagacag cacgcttaaaccgtagaccaagaaatcaggagagttcaagtgatgagcagacgcctagtc gggatgatgatagccagtccaggagtccaagtagatctcgaagtaaatctgaaaccaaat caagacacagaacaaggtctgtctcctatagtcactcaagaagtcgatc > 342 61__at HG-U95Av2 ctctaactggcctggctctggaagggctggtgaggactctgcctccttgcctgcctacaa ggtgcctggtttgcagcaggctctccgctctttccagcaaagctgctcagagagggtgtc cagcacagtggagaggccggaagtgagacgggcagacggcacctgcagcctgaaacgcac cgctcctgcgtgcgc ccccacctggtccccggatgcccccaccacctggacagaggccac

actgactgcccacccagctgtggcgggaggtgcagagcagagggctttagggagcagtga ctgcggtcacccctttagttctctgggtgtagaccacaccacctcccactgggcaccccc caacacggtgtcctgccacccagcgcctggctccaggaaaacacgcttgccttccttccc ggcannntcgccactctccttatggactctgttctgtttgtacatggctgacggaaatct ctttggt >34265_at HG-U95Av2 gatgctagacgaaaacccacattacctgttaggcctcagcatggcttatgtgcacgtgta aatggagtccctgtgaatgacagcatgtttcttacatagataattatggatacaaagcag ctgtatgtagatagtgtattgtcttcacaccgatgattctgctttttgctaaattagaat aagagcttttttgtttcttgggtttttaaaatgtgaatctgcaatgatcataaaaattaa aatgtgaatgtcaacaataaaaagcaagactatgaaaggctcagatttcttgcagtttaa aatggtgtctgaggttgtactattttggccaagtctgtagaaagctgtcatnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnntgggcattgttatacaccagtaaagaaggctgtac tcaagaggaggagctgacacatttcacttggctgcgtcttaataaacatgaatgc >34272_at HG-U95Av2 tgaattcatctcagtccaggcaaccaaagaggtgaacctggattcnnnnnnnnnnnnnnn nncaagccggaacatgctagagcctacaataacctgctttgatgaggcccagaagaagat tttcaacctgatggagaaggattcctaccgccgcttcctcaagtctcgattctatcttga tttggtcaacccgtccagctgtggggcagaaaagcagaaaggagccaagagttcagcaga ctgtgcttccctggtccctcagtgtgcctaattctcacctgaaggcagagggatgaaatg ccaagactctatgctctggaaaacctga g gnnnnnnnnnnnnnnnnat nnnnnnnnnnnn nnnnnnnnnnattgtagnctaatattcatgctgcctgccatgt >34273_at HG-U95AV2 tgatttgaccactgacagcctccaccttgagcactattctaaggagcaaataccttagct cccttgagctggttttctctgatggcacttttgagctcctaagctgccagccttcccttc ttttcctgggtgctcagggcatgcttattagcagctgggttggtatggagttggcagaca ggatgttcaacttaatgaagaaatacagctaaggccttgccagcaacacctgccgtaagt tactggctgagtgagggcatagaagttaaaggttactgtttttatcctctatcctttttt cctttcctgatcaaggtgctcttctcattttttcctgagaaccttagccatcagatgagg ctccttagtttattgtggttggttgttttttctttataatggctctgggctatatgccca tatttataaaccagcagcaggggaaagattatattttataagagggaacaaattttcaca atttgaaaagcccacataagttttctcttt t nnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnctttttaggctctgagactaaatga >34288_at HG-U95AV2 tttgcaacaggcagagctgtgtcgcacagcagtgctgtncnnnanagccagctgaggaca ggcttgcctggacttctgtaagataggattttctgtgtttcctgaattttttatatggtg atttgtatttaaattttaagactttattttctcactattggtgtaccttataaatgtatt tgaaagttaaatatattttaaatattgtttgggaggcatagtgctgacatatattcagag 78- 98677.doc 200533758 tgttgtagttttaaggttagcgtgacttcagttttgactaaggatgacactaattgttag ctgttttgaaattatatatatataaatatatataaatatataaatatatgccagtcttgg ctgaaatgttttatttaccatagttttatatctnnnnnnnnnnnnnnnnnnnnnnnnnat atggaacnnnnnnnnnnnnnnnntgcagtttgtgacattaatagtattgtaaagttacat tttaaaataaacnnnnnnnnnnnnnnnnnnnnaaatctgcacacacaacgaacagttgca tttcagagagttctctcaatttgtaagt >34304_s__at HG-U95AV2 agtacttgctaaaaatggcaacagaggagtgaggagtgctgctgtagatgacaacctcca ttctattttagaataaattcccaacttctcttgctttctatgctgtttgtagtgaaataa tagaatgagcacccattc nnnnnnnnnnnnnnnnnnnnnnnnnnnnc a tgtttgaaatga ggtctgtttaaagtggcaatctcagatgcagtttggagagtcagatctttctccttgaat atctttcgataaacaacaaggtggtgtgatcttaatatatttgaaaaaaacttcattctc gtgagtcatttaaatgtgtacaatgtacacactggtacttagagtttctgttt >34375_at HG-U95Av2 ccagatgcaatcaatgccccagtcacctgctgntataacttcaccaataggaagatctca gtgcagaggctcgcgagctatagaagaatcaccagcagcaagtgtcccaaagaagctgtgactgactgcccacccagctgtggcgggaggtgcagagcagagggctttagggagcagtga ctgcggtcacccctttagttctctgggtgtagaccacaccacctcccactgggcaccccc caacacggtgtcctgccacccagcgcctggctccaggaaaacacgcttgccttccttccc ggcannntcgccactctccttatggactctgttctgtttgtacatggctgacggaaatct ctttggt > 34265_at HG-U95Av2 gatgctagacgaaaacccacattacctgttaggcctcagcatggcttatgtgcacgtgta aatggagtccctgtgaatgacagcatgtttcttacatagataattatggatacaaagcag ctgtatgtagatagtgtattgtcttcacaccgatgattctgctttttgctaaattagaat aagagcttttttgtttcttgggtttttaaaatgtgaatctgcaatgatcataaaaattaa aatgtgaatgtcaacaataaaaagcaagactatgaaaggctcagatttcttgcagtttaa aatggtgtctgaggttgtactattttggccaagtctgtagaaagctgtcatnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnntgggcattgttatacaccagtaaagaaggctgtac tcaagaggaggagctgacacatttcacttggctgcgtcttaataaacatgaatgc > 34272_at HG-U95Av2 tgaattcatctcagtccaggcaaccaaagaggtgaacctggattcnnnnnnnnnnnnnnn nncaagccggaacatgctagagcctacaataacctgctttgatgaggcccagaagaagat tttcaacctgatggagaaggattcctaccgccgcttcctcaagtctcgattctatcttga tttggtcaacccgtccagctgtggggcagaaaagca gaaaggagccaagagttcagcaga ctgtgcttccctggtccctcagtgtgcctaattctcacctgaaggcagagggatgaaatg ccaagactctatgctctggaaaacctga g gnnnnnnnnnnnnnnnnat nnnnnnnnnnnn nnnnnnnnnnattgtagnctaatattcatgctgcctgccatgt > 34273_at HG-U95AV2 tgatttgaccactgacagcctccaccttgagcactattctaaggagcaaataccttagct cccttgagctggttttctctgatggcacttttgagctcctaagctgccagccttcccttc ttttcctgggtgctcagggcatgcttattagcagctgggttggtatggagttggcagaca ggatgttcaacttaatgaagaaatacagctaaggccttgccagcaacacctgccgtaagt tactggctgagtgagggcatagaagttaaaggttactgtttttatcctctatcctttttt cctttcctgatcaaggtgctcttctcattttttcctgagaaccttagccatcagatgagg ctccttagtttattgtggttggttgttttttctttataatggctctgggctatatgccca tatttataaaccagcagcaggggaaagattatattttataagagggaacaaattttcaca atttgaaaagcccacataagttttctcttt t nnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnctttttaggctctgagactaaatga > 34288_at HG-U95AV2 tttgcaacaggcagagctgtgtcgcacagcagtgctgtncnnnanagccagctgaggaca ggcttgcctggacttctgtaagataggattttctgtgtttcctgaattttttatatggtg atttgtatttaaattttaagactttatttt ctcactattggtgtaccttataaatgtatt tgaaagttaaatatattttaaatattgtttgggaggcatagtgctgacatatattcagag 78- 98677.doc 200533758 tgttgtagttttaaggttagcgtgacttcagttttgactaaggatgacactaattgttag ctgttttgaaattatatatatataaatatatataaatatataaatatatgccagtcttgg ctgaaatgttttatttaccatagttttatatctnnnnnnnnnnnnnnnnnnnnnnnnnat atggaacnnnnnnnnnnnnnnnntgcagtttgtgacattaatagtattgtaaagttacat tttaaaataaacnnnnnnnnnnnnnnnnnnnnaaatctgcacacacaacgaacagttgca tttcagagagttctctcaatttgtaagt > 34304_s__at HG-U95AV2 agtacttgctaaaaatggcaacagaggagtgaggagtgctgctgtagatgacaacctcca ttctattttagaataaattcccaacttctcttgctttctatgctgtttgtagtgaaataa tagaatgagcacccattc nnnnnnnnnnnnnnnnnnnnnnnnnnnnc a tgtttgaaatga ggtctgtttaaagtggcaatctcagatgcagtttggagagtcagatctttctccttgaat atctttcgataaacaacaaggtggtgtgatcttaatatatttgaaaaaaacttcattctc gtgagtcatttaaatgtgtacaatgtacacactggtacttagagtttctgttt > 34375_at HG-U95Av2 ccagatgcaatcaatgccccagtcacctgctgntataacttcaccaataggaagatctca gtgcagaggctcgcgagctatagaagaatcaccagcagcaagtgtcccaaagaagctgtg

atcttcaagaccattgtggccaaggagatctgtgctgaccccaagcagaagtgggttcag gattccatnggaccacctnggacaagcaaacccaaactccgaagacttgaacactcactc cacaacccaagaatctgcagctaacttattttcccctagctttccccagacaccctgttt tattttattataatgaattttgtttgttgatgtgaaacattatgccttaagtaatgttaa ttcttatttaagttattgatgttttaagtttatctttcatggtactagtgttttttagat acagagacttggggaaattgcttttcctcttgaaccacagttctacccctgggatgtttt gagggtctttgcadgd&tcdttadtacd >34390__at HG-U95Av2 gtacagctgtgttctggtacaacctcttgcggancgggnnaagntgactaccgaacaaga catgctgcctgccctgtgcttgtgggctgcaagtgggtctccaataagtggttccatgaa cgaggacaggagttcttgagaccttgtggatcaacagaagttgactgacatccttttctg tccttccccttcctggtccttcagcccatgtcaacgtgacagacacctttgtatgttcct ttgtatgttcctatcaggctgatttttggagaaatgaatgtttgtctggagcagagggag accatactagggcgactcctgtgtgactgaagtcccagcccttccattcagcctgtgcca tccctggccccaaggctaggatcaaagtggctgcagcagagttagctgtctagcgcctag caaggtgcctttgtacctcaggtgttttaggtgtgagatgtttnnnnnnnnnnnnnnnct gataccttgtttacatgtttgtttttatggcatttctatctattgtggct >34432一at HG-U95Av2 caggtggctcccagctgcattctgagaactctgtgattgggcaaggccctcccctgcccc accageccccacccgcctggagacacaccctcccccacaatctttctagacaggtgettc aggacagaggacaggcatggcttccccttgggcctcctcagtaggcggtctggcctgacc cccaacaaagaagcctggaggtcagagaagcaaatgcngagcctgctccctcctaagaag atcccaagaatccaatggctcagtccttggtgatctaagacagcaaagaagtgtgcaagg agggccctgttagctcccactgtcctggtttctcctcctggagtctaatttccttggccc tctgagccttttgagtctgggccctggtccaatgctgctgttgt >34636一at HG-U95Av2 tagaggggcaccttttcatggtctctgcacccagtgaacacattttactctagaggcatc acctgggaccttactc >34666一at HG-U95Av2 tgctctattgtagcatttcttgatgttgcttagtcacttatttcataaacaacttaatgt tctgaataatttcttactaaacattttgttattgggcaagtgattgaaaatagtaaatgc tttgtgtgnattgannctgnanttggncnattttcttcagagagctaaattacaattgtc atttataaaaccatcaaaaatattccatccatatactttggggacttgtagggatgcctt tctagtcctattctattgcagttatagaaaatctagtcttttgccccagttacttaaaaa taaaatattaacactttcccaagggaaacactcggctttctatagaaaattgcacttttt gtcgagtaatcctctgcagtgatacttctggtagatgtcacccagtggtttttgttaggt caaatgttcctgtatagtttttgc >34678 at HG-U95Av2 -79- 98677.doc 200533758 ccgaactatttgtcaatgaagattgtaaagccaaatgtgtaacaaaggcaaaggcttcat ttcaagagtcatccagcaatgagagaatcctgcctctgtagaccaacatccagtgtgatt ttgtgtctgagaccacaccccagtagcaggttacgccntgnnnncnnnnnncnnnnntnn nnnnnngnnnntnnnnnncnnnnnnnnnnnnnnnaacnnnnnnnnnnnnnnnnntgttat ctcttaagtattaaaagttttattttctaaagtttaaatcatgtttttcaaaatattttt caaggtggctggttccatttaaaaatcatctttttatatgtgtcttcggttctagacttc agcttttggaaattgctaaatagaattcaaaaatctctgcatcctgaggtgatatacttc atatttgtaat nnnnnnnnnnnnnnnnnnnnnnna annnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngcccacaaccattgctatattttgtatgga >34690__at HG-U95Av2 ttaaaaagccacattggagctcccttctacccactaaaaaataaccaatttttacatttt ttgagggggagtgagttttaggaaaggggaattaagattccagggagagctctggggatn nnnnnnnnnnnnnnnnnnntctctccccaagcccctttttagtgactaagtcaaggcccc aactcccctcccccaccctacgctgagcttattcgagttcattcgtactaataatccctc ctgcggcttcctcattgttgctgttttaggccaccccagctcagccaatgattcctttcc ctctgaatgtcagttttgtttttaaaagtcacttgcttannnnannnnagcgtatgtgta tttggnggggaaaancctaatttcnggggatttctgtggtaggtaatanggagaagaaan gggcactngggggctgttctccttccttccctgggatcttcaagaccattgtggccaaggagatctgtgctgaccccaagcagaagtgggttcag gattccatnggaccacctnggacaagcaaacccaaactccgaagacttgaacactcactc cacaacccaagaatctgcagctaacttattttcccctagctttccccagacaccctgttt tattttattataatgaattttgtttgttgatgtgaaacattatgccttaagtaatgttaa ttcttatttaagttattgatgttttaagtttatctttcatggtactagtgttttttagat acagagacttggggaaattgcttttcctcttgaaccacagttctacccctgggatgtttt gagggtctttgcadgd & tcdttadtacd > 34390__at HG-U95Av2 gtacagctgtgttctggtacaacctcttgcggancgggnnaagntgactaccgaacaaga catgctgcctgccctgtgcttgtgggctgcaagtgggtctccaataagtggttccatgaa cgaggacaggagttcttgagaccttgtggatcaacagaagttgactgacatccttttctg tccttccccttcctggtccttcagcccatgtcaacgtgacagacacctttgtatgttcct ttgtatgttcctatcaggctgatttttggagaaatgaatgtttgtctggagcagagggag accatactagggcgactcctgtgtgactgaagtcccagcccttccattcagcctgtgcca tccctggccccaaggctaggatcaaagtggctgcagcagagttagctgtctagcgcctag caaggtgcctttgtacctcaggtgttttaggtgtgagatgtttnnnnnnnnnnnnnnnct gataccttgtttacatgtttgtttttatggcatttctatctattgtggct > 34432 at HG-U95Av2 caggtggctccca a gctgcattctgagaactctgtgattgggcaaggccctcccctgcccc accageccccacccgcctggagacacaccctcccccacaatctttctagacaggtgettc aggacagaggacaggcatggcttccccttgggcctcctcagtaggcggtctggcctgacc cccaacaaagaagcctggaggtcagagaagcaaatgcngagcctgctccctcctaagaag atcccaagaatccaatggctcagtccttggtgatctaagacagcaaagaagtgtgcaagg agggccctgttagctcccactgtcctggtttctcctcctggagtctaatttccttggccc & gt tctgagccttttgagtctgggccctggtccaatgctgctgttgt; 34636 an at HG-U95Av2 tagaggggcaccttttcatggtctctgcacccagtgaacacattttactctagaggcatc acctgggaccttactc > 34666 a at HG-U95Av2 tgctctattgtagcatttcttgatgttgcttagtcacttatttcataaacaacttaatgt tctgaataatttcttactaaacattttgttattgggcaagtgattgaaaatagtaaatgc tttgtgtgnattgannctgnanttggncnattttcttcagagagctaaattacaattgtc atttataaaaccatcaaaaatattccatccatatactttggggacttgtagggatgcctt tctagtcctattctattgcagttatagaaaatctagtcttttgccccagttacttaaaaa taaaatattaacactttcccaagggaaacactcggctttctatagaaaattgcacttttt gtcgagtaatcctctgcagtgatacttctggtagatgtcacccagtggtttttgttaggt caaatgttcctgtatagtttttgc > 34678 at HG-U95Av2 -79- 98677.doc 200533758 ccgaactatttgtcaatgaagattgtaaagccaaatgtgtaacaaaggcaaaggcttcat ttcaagagtcatccagcaatgagagaatcctgcctctgtagaccaacatccagtgtgatt ttgtgtctgagaccacaccccagtagcaggttacgccntgnnnncnnnnnncnnnnntnn nnnnnngnnnntnnnnnncnnnnnnnnnnnnnnnaacnnnnnnnnnnnnnnnnntgttat ctcttaagtattaaaagttttattttctaaagtttaaatcatgtttttcaaaatattttt caaggtggctggttccatttaaaaatcatctttttatatgtgtcttcggttctagacttc agcttttggaaattgctaaatagaattcaaaaatctctgcatcctgaggtgatatacttc atatttgtaat nnnnnnnnnnnnnnnnnnnnnnna annnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngcccacaaccattgctatattttgtatgga > 34690__at HG-U95Av2 ttaaaaagccacattggagctcccttctacccactaaaaaataaccaatttttacatttt ttgagggggagtgagttttaggaaaggggaattaagattccagggagagctctggggatn nnnnnnnnnnnnnnnnnnntctctccccaagcccctttttagtgactaagtcaaggcccc aactcccctcccccaccctacgctgagcttattcgagttcattcgtactaataatccctc ctgcggcttcctcattgttgctgttttaggccaccccagctcagccaatgattcctttcc ctctgaatgtcagttttgtttttaaaagtcacttgcttannnnannnnagcgtatgtgta tttggnggggaaaancctaatttcnggggatttctgtggtaggtaatangga gaagaaan gggcactngggggctgttctccttccttccctggg

>34720_at HG-U95Av2 tctcaccaacgaaggctaggaggcggcgtcagagntgnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnncactctgatttctaaaagttaaaaaaaatatatgaaatctctgtnnn nnnnnnnnnnnnnnnnnnnnttattaaatttcggcccttaacccagccttttccagtgtg taacccagtttgaaatcttaaaaaaagaaaaaatgaaaaaaaaaggaaaaaaagaaaaaa g g a a a a a a a c a g 111 g a a c a c aarmrmrmrmnrmnrmrmmmnrmmmrmnrmrmmmrm nnnnnctctgcatgcaacagtaaaaattaatataatattttccccacaaaagaaacactt aacagaggcaagtgcaatttataaatttatatctaaaggggaatcatgattataagtcct tcagcccttggactctaaattgaggggattaaaaagantttaaaataattttgaannnnn ttntnttnnncncnnnnnntnnnngnnnnnnnannncattaattcaagacaaatccatgt ggcttgagg >34748_at HG-U95Av2 tgctcagcaaaattgttgagtacctgttctgggcaggtcccacgctatatgcacaaagtt aagaaaaacttggtcttagcccttngnnnnnnnnnnnnnnnnnngggcattaaggcaaag tagttccagtgatttaaaatacggttccaaatacgctaannnnnnnnnnnnnnnaccaga tttacagattggaaatactgcagatgatgtgaagttatcagttggaggagctgtgattaa gctggataataagagaacgtgccatctgtaaagcactcagaaggcagccatccctagatg ttggtttcatgtatattacactatctactactatccataaatgcaatnatatgcatgtta acaacattaaaaacagcaaacagcaatctaagtacagaaaagctttttgtgtgtttaaaa aaattgaagaaaattcaggaagaaacgtgttaataaacattgtactgttcttttgcttct caaaggaantattcacttgccactttggttatttttgagttttcgtacataggaagtttt atattgccagccttcctgtgataaagatattaa >34759_at HG-U95Av2 caaattgccatgttatggttctgccttgaaacagcacaatgaagtgtatcagtatattct gtgattatgaaacttatatgttgtgttgttttgtgtcttctgttgcctgtcctttgggcc agatgtgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnttacctaactttttgtatgttttcatgactgtgtgttattttc caaagctgttcctacctcaccatgaggctttatggattgtt >34760_at HG-U95Av2 cttgtagtgagcagtgtatggtctcttttgttcagaatttaaaactgataaccaatgaaa gccttttctcttattcctctaccgtcatttacatgataatctgaagctaatatgacaata tttaaatactaagtggtactagggaactacaagaatactgtaaagcttaagccattgtta tcactgtcatttagcatttaataacaaaactatacagaattatgtgcataccaatgaatg ttttgtaccatctagttaaattttttaaataaagttttatgggttaagcagaananaann nnnatactgaattttattaaaagtatatatacttcaaattcaaagcatcccttaggaccc acagaatatattaaaactaccacccttaaattttatatttttgctttaagacagacaatg caaaggtaactggcaagaggtgagcaaatgttttagaacatttatattattgcttaaaat gagatttgaaattgtaataaaattcttgnntatgaagtctgatgtcttctctgagcac 80- 98677.doc 200533758 >34876_at HG-U95Av2 tgaggtgcccaacacccattcatctcaagtgcttcagtctttggtttatttcatgcactg tgccttcaaaatgaaatttttaaaagggactttaaatgaagttgaatagtagtttttaaa agtcaatttgtaatttatgtgaaatctaactgtaatgaggtcctttctgttttttatatg taaacagatctactaatcctgtataaaagttattttacgaanaaaaanaaaaaaaaaaaa nnnn ctcataatcttttttc a ga t gnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnntatttagtttttctgcctatgctagtggaaaaatagtaccaggatcagaatacaggg tatcacctatggaatgtttctgtatttatgaattgactcaaaagaaagctttgtttctga aatcgcat >34886_at HG-U95Av2 atcatacagatcaggcagtgtttaaaatgatggtaggtagcacagtggacagtctttgat catcatgtagaatatggctatgaatcaggaaagagattagaacatttaataatgtatgta cagctggtgcttagtttttttttaatctaaatttaattaccttattggatatttgatatt tggttatttaatcacannnnnnnnnnnnnnnnnnnnctgattggtgttttatctcctgtg atcctttgatggctttttttgcctaccatttcacagaggtttagacagcagtagtagctc cctaggagagtttactgatgaaacagcctctgcaagaacaacattaaaaa 34748_at HG-U95Av2 tgctcagcaaaattgttgagtacctgttctgggcaggtcccacgctatatgcacaaagtt aagaaaaacttggtcttagcccttngnnnnnnnnnnnnnnnnnngggcattaaggcaaag tagttccagtgatttaaaatacggttccaaatacgctaannnnnnnnnnnnnnnaccaga tttacagattggaaatactgcagatgatgtgaagttatcagttggaggagctgtgattaa gctggataataagagaacgtgccatctgtaaagcactcagaaggcagccatccctagatg ttggtttcatgtatattacactatctactactatccataaatgcaatnatatgcatgtta; > 34720_at HG-U95Av2 tctcaccaacgaaggctaggaggcggcgtcagagntgnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnncactctgatttctaaaagttaaaaaaaatatatgaaatctctgtnnn nnnnnnnnnnnnnnnnnnnnttattaaatttcggcccttaacccagccttttccagtgtg taacccagtttgaaatcttaaaaaaagaaaaaatgaaaaaaaaaggaaaaaaagaaaaaa g g a a a a a a a c a g 111 g a a c a c aarmrmrmrmnrmnrmrmmmnrmmmrmnrmrmmmrm nnnnnctctgcatgcaacagtaaaaattaatataatattttccccacaaaagaaacactt aacagaggcaagtgcaatttataaatttatatctaaaggggaatcatgattataagtcct tcagcccttggactctaaattgaggggattaaaaagantttaaaataattttgaannnnn ttntnttnnncncnnnnnntnnnngnnnnnnnannncattaattcaagacaaatccatgt ggcttgagg & gt cagcaaacagcaatctaagtacagaaaagctttttgtgtgtttaaaa aaattgaagaaaattcaggaagaaacgtgttaataaacattgtactgttcttttgcttct caaaggaantattcacttgccactttggttatttttgagttttcgtacataggaagtttt atattgccagccttcctgtgataaagatattaa > 34759_at HG-U95Av2 caaattgccatgttatggttctgccttgaaacagcacaatgaagtgtatcagtatattct gtgattatgaaacttatatgttgtgttgttttgtgtcttctgttgcctgtcctttgggcc agatgtgnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnttacctaactttttgtatgttttcatgactgtgtgttattttc caaagctgttcctacctcaccatgaggctttatggattgtt > 34760_at HG-U95Av2 cttgtagtgagcagtgtatggtctcttttgttcagaatttaaaactgataaccaatgaaa gccttttctcttattcctctaccgtcatttacatgataatctgaagctaatatgacaata tttaaatactaagtggtactagggaactacaagaatactgtaaagcttaagccattgtta tcactgtcatttagcatttaataacaaaactatacagaattatgtgcataccaatgaatg ttttgtaccatctagttaaattttttaaataaagttttatgggttaagcagaananaann nnnatactgaattttattaaaagtatatatacttcaaattcaaagcatcccttaggaccc acagaatatattaaaactaccacccttaaattttatatttttgctttaagacagacaatg caaaggtaactggcaagaggtgagcaaatgttttaga acatttatattattgcttaaaat gagatttgaaattgtaataaaattcttgnntatgaagtctgatgtcttctctgagcac 80- 98677.doc 200533758 > 34876_at HG-U95Av2 tgaggtgcccaacacccattcatctcaagtgcttcagtctttggtttatttcatgcactg tgccttcaaaatgaaatttttaaaagggactttaaatgaagttgaatagtagtttttaaa agtcaatttgtaatttatgtgaaatctaactgtaatgaggtcctttctgttttttatatg taaacagatctactaatcctgtataaaagttattttacgaanaaaaanaaaaaaaaaaaa nnnn ctcataatcttttttc a ga t gnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnntatttagtttttctgcctatgctagtggaaaaatagtaccaggatcagaatacaggg tatcacctatggaatgtttctgtatttatgaattgactcaaaagaaagctttgtttctga aatcgcat > 34886_at HG-U95Av2 atcatacagatcaggcagtgtttaaaatgatggtaggtagcacagtggacagtctttgat catcatgtagaatatggctatgaatcaggaaagagattagaacatttaataatgtatgta cagctggtgcttagtttttttttaatctaaatttaattaccttattggatatttgatatt tggttatttaatcacannnnnnnnnnnnnnnnnnnnctgattggtgttttatctcctgtg atcctttgatggctttttttgcctaccatttcacagaggtttagacagcagtagtagctc cctaggagagtttactgatgaaacagcctctgcaaga

>34887_at HG-U95Av2 gcactaccatagctacatcagtttgatacagtattgaaaaattatcagttatattttgct gtttatgatctatttgtagattaggattaaaatggatttaatccatttttaaggctgtgt gaatttttctaaacaagaaccatttgcaatatggatttcttagagattaaaccaattata acttattagcagtcgcgagcacatgttcatatagtcaatgtaaaaatacactaatgagta tttggtaaatcccagtaggcttttaccattagcataattttgtgttgtacaattaagtta caattacatctctaattttggataatattcattggttaacaataaagtgacaaaagctca nnnnnnnaaannnnanngnnnnnannnaacatggattttttgtatgtttcttgaaaatta caatctttatcacagccatgaatcaccacaacttaaaagtaagaagtagataggaaataa ttttaaatcctcatagatntactctttccccgatacctctttggtatg >34916_s_at HG-U95Av2 ccaactgcaccttggctgggaagcacaccctgcagccggccagcaatagctcggacgcaa tctgtgaggacagggaccccccagccacgcagccccaggagacccagggccccccggcca ggcccatcactgtccagcccactgaagcctggcccagaacctcacagggaccctccaccc ggcccgtggaggtccccgggggncnnncggtnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncggagggaccaga ggctgccccccgatgcccnacaagncccctgggggaggcagtttccggacccccatccaa gaggagcaggccgacg >34975_at HG-U95Av2 cagatctgtcatgtatccctaaaaggagggagctggccactggctnttgggaaagccatg agtatatagttagcaaatactgaactttctcagatatggcattagatgcaagacaacctc ctagggattgatgcctaactgatggattctctttgagactatttagatattatgtgagca atttaaagaccagatctaagcaaattttgaaatagatgtttgttttttgtatttctcagt atggaaactaatgctgccactctcatccccgtcccaaccatctctgtcaaaaatatacct ttttcatatgatattctgagctaatctgataaaatctatgccaatatatactattgcttg tgt >35017_f_at HG-U95Av2 tacctggagggcacctgcatggagtggctccgcagacacctggagaacgggaaggagacg ctgcagcgcgcggacccccccnaagacacacgtgacccaccnccctnnctctgaacatga ggcataacgaggtnctgggttctgggcttctaccctgcggagatcacattgacctggcag cgggatggggaggaccagacccaggacatggagctcgtggagaccaggcccacaggggat ggaaccttccagaagtgggcggttgtggtagtgccttctggagaggaacagagatacaca tgccatgtgcagcacaaggggcntgcccaagccccteatcctgagatgggagccctctcc ccagcccaccatccccattgtgggtatcattgctggcctggttctccttgg >35025_at HG-U95Av2 tttctggaggtctctgaacccagggaagacaagaaggaaagattttgttgttgtttgttt atttggtttccccagtagttagctttcttccctggattcctcacttttgaagagtgtgag gaaaacctatgtttggcgcttaagctttcagctcagcttaatgaagtgtttagcatagta -81 - 98677.doc 200533758 cctctgctatttgctgttattttatctgctatgctattgaagtttnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnntaatcttacaaagtgtcttggaattgtaggtgact attatttttccaagaaatatcccttaagatattaactgagaaggctgggggtttaatgtg gaaatgatgtttcaaaaggaatcctgtgatggaaatacaactggtatcttcactttttta ggaattgggaaatattttaatgtttcttggggaatatgttagagaattcccttactcttg attgtgggatactatttaattatttcactttagaaagctgagtgtttcacaccttatcta tgtag >35153一at HG-U95AV2 tacattctagatgcaagtctcttgtcggatatangtattgagatattacacctagtctgt ggcttgactgttttctttatgtcttttgatgaatagaagttttaaattttgacaaggtca aatttatttttttcttttgtttgatattttttctctccaatttaaccccaagatttcaga tattctgctctattatataaactttatatttttatatttgtgatctaccttgaattgata tgtatgttgtgaattatggatcagggttctttttttcccccatacaagtatccagtcatt gtaacactgtttattg >35168_f_at HG-U95Av2cagatctgt 34975_at HG-U95Av2; > 34887_at HG-U95Av2 gcactaccatagctacatcagtttgatacagtattgaaaaattatcagttatattttgct gtttatgatctatttgtagattaggattaaaatggatttaatccatttttaaggctgtgt gaatttttctaaacaagaaccatttgcaatatggatttcttagagattaaaccaattata acttattagcagtcgcgagcacatgttcatatagtcaatgtaaaaatacactaatgagta tttggtaaatcccagtaggcttttaccattagcataattttgtgttgtacaattaagtta caattacatctctaattttggataatattcattggttaacaataaagtgacaaaagctca nnnnnnnaaannnnanngnnnnnannnaacatggattttttgtatgtttcttgaaaatta caatctttatcacagccatgaatcaccacaacttaaaagtaagaagtagataggaaataa ttttaaatcctcatagatntactctttccccgatacctctttggtatg > 34916_s_at HG-U95Av2 ccaactgcaccttggctgggaagcacaccctgcagccggccagcaatagctcggacgcaa tctgtgaggacagggaccccccagccacgcagccccaggagacccagggccccccggcca ggcccatcactgtccagcccactgaagcctggcccagaacctcacagggaccctccaccc ggcccgtggaggtccccgggggncnnncggtnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncggagggaccaga ggctgccccccgatgcccnacaagncccctgggggaggcagtttccggacccccatccaa gaggagcaggccgacg & gt catgtatccctaaaaggagggagctggccactggctnttgggaaagccatg agtatatagttagcaaatactgaactttctcagatatggcattagatgcaagacaacctc ctagggattgatgcctaactgatggattctctttgagactatttagatattatgtgagca atttaaagaccagatctaagcaaattttgaaatagatgtttgttttttgtatttctcagt atggaaactaatgctgccactctcatccccgtcccaaccatctctgtcaaaaatatacct ttttcatatgatattctgagctaatctgataaaatctatgccaatatatactattgcttg tgt > 35017_f_at HG-U95Av2 tacctggagggcacctgcatggagtggctccgcagacacctggagaacgggaaggagacg ctgcagcgcgcggacccccccnaagacacacgtgacccaccnccctnnctctgaacatga ggcataacgaggtnctgggttctgggcttctaccctgcggagatcacattgacctggcag cgggatggggaggaccagacccaggacatggagctcgtggagaccaggcccacaggggat ggaaccttccagaagtgggcggttgtggtagtgccttctggagaggaacagagatacaca tgccatgtgcagcacaaggggcntgcccaagccccteatcctgagatgggagccctctcc ccagcccaccatccccattgtgggtatcattgctggcctggttctccttgg > 35025_at HG-U95Av2 tttctggaggtctctgaacccagggaagacaagaaggaaagattttgttgttgtttgttt atttggtttccccagtagttagctttcttccctggattcctcacttttgaagagtgtgag gaaaacctatgtttggcgcttaagctttcagctcagcttaatgaagtgttt agcatagta -81 - 98677.doc 200533758 cctctgctatttgctgttattttatctgctatgctattgaagtttnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnntaatcttacaaagtgtcttggaattgtaggtgact attatttttccaagaaatatcccttaagatattaactgagaaggctgggggtttaatgtg gaaatgatgtttcaaaaggaatcctgtgatggaaatacaactggtatcttcactttttta ggaattgggaaatattttaatgtttcttggggaatatgttagagaattcccttactcttg attgtgggatactatttaattatttcactttagaaagctgagtgtttcacaccttatcta tgtag > 35153 a at HG-U95AV2 tacattctagatgcaagtctcttgtcggatatangtattgagatattacacctagtctgt ggcttgactgttttctttatgtcttttgatgaatagaagttttaaattttgacaaggtca aatttatttttttcttttgtttgatattttttctctccaatttaaccccaagatttcaga tattctgctctattatataaactttatatttttatatttgtgatctaccttgaattgata tgtatgttgtgaattatggatcagggttctttttttcccccatacaagtatccagtcatt gtaacactgtttattg > 35168_f_at HG-U95Av2

taaatggccaaagcttataggactctgtgacaggttgt >35261_at HG-U95Av2 cgcctagaagacagcggaactaagaaaagaagaggcctgtggacannnnnnnnnnnnnnn nnnnnnnnnnnnnnnncgaggtagacccagagctaacagaaaagctgaggaaattccgct tccgaaaagagacagacaatgcagccatcataatgaaggtggacaaagaccggcagatgg tggtgctggaggaagaatttcagaacatttccccagaggagctcaaaatggagttgccgg agagacagcccaggttcgtggtttacagctacaagtacgtgcatgacgatggccgagtgt cctaccctttgtgtttcatcttctncnnccctgtgggctgcaagccggnaacaacagatg atgtatgca g gnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc aaaggtgttcgaa atccgcaccactgatgacctcactgaggcctggctccaagaaaagttgtctttctttcgt tgatctctgggctggggannnnnnnnnnnnnnnctgagtcctcaaggtgactggggact >35280_at HG-U95Av2 gatgcgcatcaatgtattttatcttattttctcaatctcctctctctttcctccacccat aataagagaatgttcctactcacacttcagctgggtcacatccatccctccattcatcct tccatccatctttccatccattacc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntaaatttaaacttacaaacnnnnnt tgncacaagtggtgtttattgcaataaccgcttggtttgcaacctctttgctcaacagaa catatgttgcaagaccctcccatgggggcacttgagttttggcaaggctgacagagctct gggttgtgcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnntaacaccagtgggaattgctggaggaaccagaggcacttc caccttggctgggaagactatggtgctgccttgcttct >35281_at HG-U95Av2 ataagcaacttcacagaacacgagacagcttgggaatcnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnngacagttttaagcagaggaataacatcaccactgtatatttcag aaagatcactagggcagcc >35320一at HG-U95Av2 gttcttgttcttcttaaatgtgacatgaaataattgtgctgctacattatactggaaatt aacaggggaaaagggaagagctcttggctcccttgaggttctgctagtggtgttaggagt ggttacaactgagcttttagtaaccatttaaccgtatgtaaacttggtttctaattaaaa aaaaatttctttttccaaaaaannaannnnnnnnnnnnnttaannnnnaantnntttntn nanannnntacaacaactttgatacaaaaatactgaaacagcaactaccacctggaatgg cacactaagtccacactgttaggattttctccttagaaag >35350_at HG-U95Av2 taatgaggctcctccgctctggacacaacccttttatagattaatttctctgccaattaa cttgtcattttcagtacatattttactattccacaccaaccataattacaacaagggatt tttcttatgcactcctatgcatgtgaataacatgtggtgtaattctgcttcttacagaag tattactgaaggtattatttccaatattatttggtttattatgcggatcttttttatata tgcagtcccatcccttctgtgccactcaatgccatccagacatggtttttccctccaggg 82- 98677.doc 200533758 gcctnnnntctccagagggcacttcggctgcctctgcttcctctcattcgaggcccggct cttgctgacagaataggttccgttctgggcggtggttctcgagcctgccattcaaaacca aagcaaattggagcatttctcacaacatggtattgaagttcctttttgttctcaaaagtt gtgaccgtgttaaattgtactcccttagtcctgtaag >35366_at HG-U95Av2 aatggtacattttgccaaagaccacttatacttgagaacatggaagaatttgcctgatac tctctttggggaaaagagtctctcctcttttcctcaaaccccagtacactcagcctctct gnccccaccttctccntgactttngtcctcacttngcttctgcagtancattggaacctn gaattngaaagaaagtcttccttngaataattnggagtttgtcttgagaggcaaatatag ccccaagaatcacaagattcgaggaccatgtaggtcttttacgtagcccaaatccataaa ttagtctcactttttgtatttatcgtttcatattaaaccctctatatcaaatgttcatca tgattttgtatgatttttataactattttattcattttattagatttattctaaaatttt ttaatggtaaattcttaaactgtggaaaccactgaaggtgcttattaeictgttctcccag atttgtacaagtattggatgattccttgagtttacagc >3 53 67__at HG-U95Av2taaatggccaaagcttataggactctgtgacaggttgt > 35261_at HG-U95Av2 cgcctagaagacagcggaactaagaaaagaagaggcctgtggacannnnnnnnnnnnnnn nnnnnnnnnnnnnnnncgaggtagacccagagctaacagaaaagctgaggaaattccgct tccgaaaagagacagacaatgcagccatcataatgaaggtggacaaagaccggcagatgg tggtgctggaggaagaatttcagaacatttccccagaggagctcaaaatggagttgccgg agagacagcccaggttcgtggtttacagctacaagtacgtgcatgacgatggccgagtgt cctaccctttgtgtttcatcttctncnnccctgtgggctgcaagccggnaacaacagatg atgtatgca g gnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc aaaggtgttcgaa atccgcaccactgatgacctcactgaggcctggctccaagaaaagttgtctttctttcgt tgatctctgggctggggannnnnnnnnnnnnnnctgagtcctcaaggtgactggggact > 35280_at HG-U95Av2 gatgcgcatcaatgtattttatcttattttctcaatctcctctctctttcctccacccat aataagagaatgttcctactcacacttcagctgggtcacatccatccctccattcatcct tccatccatctttccatccattacc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntaaatttaaacttacaaacnnnnnt tgncacaagtggtgtttattgcaataaccgcttggtttgcaacctctttgctcaacag aa catatgttgcaagaccctcccatgggggcacttgagttttggcaaggctgacagagctct gggttgtgcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnntaacaccagtgggaattgctggaggaaccagaggcacttc caccttggctgggaagactatggtgctgccttgcttct > 35281_at HG-U95Av2 ataagcaacttcacagaacacgagacagcttgggaatcnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnngacagttttaagcagaggaataacatcaccactgtatatttcag aaagatcactagggcagcc > 35320 a at HG-U95Av2 gttcttgttcttcttaaatgtgacatgaaataattgtgctgctacattatactggaaatt aacaggggaaaagggaagagctcttggctcccttgaggttctgctagtggtgttaggagt ggttacaactgagcttttagtaaccatttaaccgtatgtaaacttggtttctaattaaaa aaaaatttctttttccaaaaaannaannnnnnnnnnnnnttaannnnnaantnntttntn nanannnntacaacaactttgatacaaaaatactgaaacagcaactaccacctggaatgg cacactaagtccacactgttaggattttctccttagaaag > 35350_at HG-U95Av2 taatgaggctcctccgctctggacacaacccttttatagattaatttctctgccaattaa cttgtcattttcagtacatattttactattccacaccaaccataattacaacaagggatt tttcttatgcactcctatgcatgtgaataacatgtggtgtaattctgcttcttacagaag tattactgaaggtattatttccaatattatttg gtttattatgcggatcttttttatata tgcagtcccatcccttctgtgccactcaatgccatccagacatggtttttccctccaggg 82- 98677.doc 200533758 gcctnnnntctccagagggcacttcggctgcctctgcttcctctcattcgaggcccggct cttgctgacagaataggttccgttctgggcggtggttctcgagcctgccattcaaaacca aagcaaattggagcatttctcacaacatggtattgaagttcctttttgttctcaaaagtt gtgaccgtgttaaattgtactcccttagtcctgtaag > 35366_at HG-U95Av2 aatggtacattttgccaaagaccacttatacttgagaacatggaagaatttgcctgatac tctctttggggaaaagagtctctcctcttttcctcaaaccccagtacactcagcctctct gnccccaccttctccntgactttngtcctcacttngcttctgcagtancattggaacctn gaattngaaagaaagtcttccttngaataattnggagtttgtcttgagaggcaaatatag ccccaagaatcacaagattcgaggaccatgtaggtcttttacgtagcccaaatccataaa ttagtctcactttttgtatttatcgtttcatattaaaccctctatatcaaatgttcatca tgattttgtatgatttttataactattttattcattttattagatttattctaaaatttt ttaatggtaaattcttaaactgtggaaaccactgaaggtgcttattaeictgttctcccag atttgtacaagtattggatgattccttgagtttacagc > 3 53 67__at HG-U95Av2

acaattctgggcacggtgaagcccaatgcaaacagaattgctttagatttccaaagaggg aatgatgttgccttccactttaancccacgcttcaatgagaacaacaggagagtcattgt ttgcaatacanaangctggataataacntggggaagggaagaaagacagtcggttttccc atttgaaagtgggaaanccattc annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaa atcagcaaactgggaatttctggtgacatagacctcaccagtgcttcatataccatgata taatctgaaaggggcagattaaaaaaaaaaaaagaatctaaaccttacatgtgtaaaggt ttcatg >35372_r_at HG-U95Av2 tatttgtgcaagaatttggaaaaatagaagatgaatcattgattgaatagttataaagat gttatagtaantttattttattttagatattaaatgatgttttattagataaatttcaat cagggtttttagattaaacaaacaaacaattgggtacccagttaaattttcatttcagat anacaacaaataattttttagtataagtacattattgtttatctgaaattttaattgaac taacaatcctagtttgatactcccagtcttnnnnnnnnnnnnnnngttggtagtgctgtg ttgaattacggaataatgagttagaactattaaaacagccaaaactccacagtcaatatt agtaatttcttgctggttgaaacttg >35396_at HG-U95Av2 aaatcctgcccaaaatgtgaagcttggttgactgatgttcatgatagaaagaataaaatg tttctctctctctannnnnnaaaannnaanagtttatttctgtgaaagaagtatttaaac tttcaatattttaactttttgtttttatttcttttagaaaaggccaatatacctatcncn ctttggaagtaaaaatacacactttcgtgtgtacctaaaaaaaaaatcgttgaaaatcaa ggccaaaggtagtgcaattttttcattaagatttaaaaaaaagggaatgatagtctttga aagaaaacagtaggcatccagcactggacaaaacatgggtatcaaagatgaataatcttt ggagattctggcagtgttttcccagaacaagtcaag >35410_at HG-U95Av2 ccctaggatgctatttaagttgtactgtattagaacactgggtgtgtcataccgttatct gtgcagaatatatttccttattcagaatttctaaaaatttaagttctgtaagggctaata tattctcttcctatggttttnnnnnnnnnnnnnnnnnttagtatggcataatgtcatgat ttactcattaaactttgattttgtatgctattttttcactataggatgactannnnnnnn nnnnnnnnntatacactttagatagatgaagaagcccaaaaacagataaattcctgattg ctaatttacatagaaatgtattctcttggttttttaaataaaagcaaaattaacaatgat ctgtgctctgaaagttttgaaaatatatttgaacaatttgaatataaatteatcatttag tcctcaaaatatatacagcattgctaagattttcagatatc >35414_s_at HG-U95Av2 gccttctactggtgcctgcggaagcggcggaagccgggcagccacacacactcagcctct gaggacaacaccancaacaacgtgcgggannnnntgaannnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnncaacacggtccccannnagnantangngaacaagttgagctatgactta acatagccaaaatgtgagtggttgaatatgattaaaaatatcaaattaattgtgtgaact tggaagcacaccaatcttactttgtaaattctgatttcttttcaccattcgtacataata ctgaaccacttgtagatttgatttttttttttaatctactgcatttagggagtattctaa S3- 98677.doc 200533758 taagctagttgaatacttgaaccataaaatgtccagtaagatcactgtttagatttgcca tagagtacactgcctgccttaagtgaggaaatnnnnnnnnnnnnnnnaagttcnnnnnnn nnnnnnnnnataaaacagagtaatcttgttggttcaccattgagaccgtgaagatacttt gtattgtcctattagtgttatatgaacatacaaatgcatctttgatg >35628_at HG-U95Av2 gcctctgtcatctgcctcatcaatgctantggttactacatctnccgtggggncgaattc cnagaaaaacacttnccgaaagaatccttctgaccccagagtggctgggcttgagaccat ctctacagccacagggcggaaactgctggtgtctgggtggtggggtatggtccgccatcc caactatcttggagacctcatcatggctctggcttggtccttgccntgcggggtgtcaca cctgctgccctacttctacctcctctacttcaccgcgctgctggtgcaccgtgaggcccg ggatgagnnnnnnnnnnnnnnnnnnnnnnnnnnggcctggcaggagtactgccggcgtgt gccttaccgcatcatgccctacatctactgaagcggctccaccaccccaggtggggncat gtgcccactcatccaccagcacacccaggaccaggagcctcgacacacttgggactcaag ggcttgcaccccacccagccctgaggatgaacaacctcag >35638_at HG-U95Av2 tcacttttgcaagttccacagagtaagacattgggtctattccagctcattcattttata ttgaaaaaaataattttaaaaatggtggcttcagctccagcccctttccaaaatttttcaacaattctgggcacggtgaagcccaatgcaaacagaattgctttagatttccaaagaggg aatgatgttgccttccactttaancccacgcttcaatgagaacaacaggagagtcattgt ttgcaatacanaangctggataataacntggggaagggaagaaagacagtcggttttccc atttgaaagtgggaaanccattc annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaa atcagcaaactgggaatttctggtgacatagacctcaccagtgcttcatataccatgata taatctgaaaggggcagattaaaaaaaaaaaaagaatctaaaccttacatgtgtaaaggt ttcatg > 35372_r_at HG-U95Av2 tatttgtgcaagaatttggaaaaatagaagatgaatcattgattgaatagttataaagat gttatagtaantttattttattttagatattaaatgatgttttattagataaatttcaat cagggtttttagattaaacaaacaaacaattgggtacccagttaaattttcatttcagat anacaacaaataattttttagtataagtacattattgtttatctgaaattttaattgaac taacaatcctagtttgatactcccagtcttnnnnnnnnnnnnnnngttggtagtgctgtg ttgaattacggaataatgagttagaactattaaaacagccaaaactccacagtcaatatt agtaatttcttgctggttgaaacttg > 35396_at HG-U95Av2 aaatcctgcccaaaatgtgaagcttggttgactgatgttcatgatagaaagaataaaatg tttctctctctctannnnnnaaaannnaanagtttatttctgtgaaagaagtatttaaac tt tcaatattttaactttttgtttttatttcttttagaaaaggccaatatacctatcncn ctttggaagtaaaaatacacactttcgtgtgtacctaaaaaaaaaatcgttgaaaatcaa ggccaaaggtagtgcaattttttcattaagatttaaaaaaaagggaatgatagtctttga aagaaaacagtaggcatccagcactggacaaaacatgggtatcaaagatgaataatcttt ggagattctggcagtgttttcccagaacaagtcaag > 35410_at HG-U95Av2 ccctaggatgctatttaagttgtactgtattagaacactgggtgtgtcataccgttatct gtgcagaatatatttccttattcagaatttctaaaaatttaagttctgtaagggctaata tattctcttcctatggttttnnnnnnnnnnnnnnnnnttagtatggcataatgtcatgat ttactcattaaactttgattttgtatgctattttttcactataggatgactannnnnnnn nnnnnnnnntatacactttagatagatgaagaagcccaaaaacagataaattcctgattg ctaatttacatagaaatgtattctcttggttttttaaataaaagcaaaattaacaatgat ctgtgctctgaaagttttgaaaatatatttgaacaatttgaatataaatteatcatttag tcctcaaaatatatacagcattgctaagattttcagatatc > 35414_s_at HG-U95Av2 gccttctactggtgcctgcggaagcggcggaagccgggcagccacacacactcagcctct gaggacaacaccancaacaacgtgcgggannnnntgaannnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnncaacacggtccccannnagnantangngaacaagttgagctatgactta acatagccaaaatgtgagtgg ttgaatatgattaaaaatatcaaattaattgtgtgaact tggaagcacaccaatcttactttgtaaattctgatttcttttcaccattcgtacataata ctgaaccacttgtagatttgatttttttttttaatctactgcatttagggagtattctaa S3- 98677.doc 200533758 taagctagttgaatacttgaaccataaaatgtccagtaagatcactgtttagatttgcca tagagtacactgcctgccttaagtgaggaaatnnnnnnnnnnnnnnnaagttcnnnnnnn nnnnnnnnnataaaacagagtaatcttgttggttcaccattgagaccgtgaagatacttt gtattgtcctattagtgttatatgaacatacaaatgcatctttgatg > 35628_at HG-U95Av2 gcctctgtcatctgcctcatcaatgctantggttactacatctnccgtggggncgaattc cnagaaaaacacttnccgaaagaatccttctgaccccagagtggctgggcttgagaccat ctctacagccacagggcggaaactgctggtgtctgggtggtggggtatggtccgccatcc caactatcttggagacctcatcatggctctggcttggtccttgccntgcggggtgtcaca cctgctgccctacttctacctcctctacttcaccgcgctgctggtgcaccgtgaggcccg ggatgagnnnnnnnnnnnnnnnnnnnnnnnnnnggcctggcaggagtactgccggcgtgt gccttaccgcatcatgccctacatctactgaagcggctccaccaccccaggtggggncat gtgcccactcatccaccagcacacccaggaccaggagcctcgacacacttgggactcaag ggcttgcaccccacccagccctgaggatgaacaacctcag > 35638_at HG-U95Av2 tcactttt gcaagttccacagagtaagacattgggtctattccagcttcattttat ttgaaaaaaataatattattaaaaatggtggcttcagctccagcccctttccaaaatttttca

accccaccctgtttggatttttaattaaaaactagtagttctcttggtgttaaaacactt ctgtcctgtgaggtttcccaatggtgtttttcttgtaaatgtgttggacaaatgtgaaga tgcattgtagtttaaccatatgcccacatttagtctctttattcctagttggtgagaaac ctgt >35664_at HG-U95Av2 gtacactcaagtctaagaatatatgagtggatcatttaccgccccccgccccacnnnnnn nnnnnnnnnnnnnnngtcnttttnnnnaataangtattcttctatggtagtannnnccta cagatctgnnncccttcttcttctaangggtaagtcataatctgtgtaatactacaattt atgggatgctcactatgccctgtttctcttctaaacaatttacatgtaatgtctcattcc tcacaataacccttgtaaagtgggcatgattanccatgatttttatagttgaagaaccta agacacagagaccaaggcccatgagctcatagggctgaggcaggatttggaatcaggcca tgtcttctccagagcccacatccatcctttctctatattgcctcccacagatgtgctaaa atttatttaactaatcctttatcctctatttgtgttgtctcccattttttattattacaa tattactgtggtgaacatgc >35666_at HG-U95Av2 gaagaaggggccatcacaggatgccacccctgncntgggttgggnnnnnnnnnncacgac cagccccttcctgggtatttattctctatttattggggataggagaagaggcatcctgcc tgggtgggacagccccttcagccccttctcccctccccgcctggccanggcagggccacc ccactctacctccttagcttt cnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnagagctgacgggaggccccagctctgaggggagggggtccgtg gtanangcctggggccggtagaggctccccagggctcccttatgtccnnnnnnnnnnnnn nngggtgtggatgtaattagctctggggggcagttgggtagatgggtgggggctcctggt ggccttntgctgcccaggccacagccgcctttgggttccatcttgctaataaacactggc tctgggactagaaa >35702_at HG-U95Av2 aggaatgtgccctggagatcatcaaagggggagctctgcgccaagaagaagtgtattatg acagctcactctggaccactcttctgatcagaaatccatgcaggaagatcctggaatttc tctactcaacgagctataatatggacagatteataaacaagtaggaactccctgagggct gggcatgctgagggattttgggactgttctgtctcatgtttatctgagctcttatctatg aagacatcttcccagagtgtccccagagacatgcaagtcatgggtcacacctgacaaatg gaaggagttcctctaacatttgcaaaatggaaatgtaataataatgaatgtcatgcaccg ctgcagccagcagttgtaaaattgt >35724_at HG-U95Av2 acttcaaattggacccaggagccaaacattcccaacctatccctaaagggtggacaagct tcatttacacgatatctgnagatgtgtatattgggcccgatgatgcacaacaaaaaatag aacctcateacacageagtgcttggagaaggrgacagtgtccangtggagaacaaggatc ccaagagaagccactttgtcttaattgctggggagccattaagagaaccagttatccaac atggtccatttgtgatgaacaccaatgaagagatttctcaagctattcttgatttcagaa 84- 98677.doc 200533758 acgcaaaaaatgggtttgaaagggccaaaacctggaaatcaaagattgggaactagtgga aagcggaagagcaggtcttgatgtgtcctagaattttgccatttnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnaagcttatttagccggtgcttctaaagaattccacactaacg tgataacatggtttttgtaacaataaatgtaggatatttcctggc^catgcaaa >35735_at HG-U95Av2 acacggtctatgagcaataatgtgatttctggacatngcccatgtataatcctcactgat gatttcaagctaangcaaaccacctnatacagagatctagaatctctttatgttctccag aggaaggtggaagaaaccatgggcaggagtaggaattgagtgataaacaattgggctaat gaagaaaacttctcttatnnnnnnnnnnnnnnnnattataacttcaatgggacactttag accattagacaattgacactggattaaacaaattcacataatgccaaatacacaatgtat ttatagcaacgtataatttgcaaagatggactttaaaagatgctgtgtaactaaactgaa ataattcaattacttattatttagaatgttaaagcttatgatagtcttttctaattctta acactcatacttgaaatctttctgagtttccccagaagagaatatgggattttttttgac atttttgacncatttaataatgctcttgtgtttacctagtatatgtagactttgtcttat gtgtcaaaagtcc >35766_at HG-U95Av2 tgaggagagcaccacagtggtcaccnacacagtctgctgaggttggagctgctgagacgaaccccaccctgtttggatttttaattaaaaactagtagttctcttggtgttaaaacactt ctgtcctgtgaggtttcccaatggtgtttttcttgtaaatgtgttggacaaatgtgaaga tgcattgtagtttaaccatatgcccacatttagtctctttattcctagttggtgagaaac ctgt > 35664_at HG-U95Av2 gtacactcaagtctaagaatatatgagtggatcatttaccgccccccgccccacnnnnnn nnnnnnnnnnnnnnngtcnttttnnnnaataangtattcttctatggtagtannnnccta cagatctgnnncccttcttcttctaangggtaagtcataatctgtgtaatactacaattt atgggatgctcactatgccctgtttctcttctaaacaatttacatgtaatgtctcattcc tcacaataacccttgtaaagtgggcatgattanccatgatttttatagttgaagaaccta agacacagagaccaaggcccatgagctcatagggctgaggcaggatttggaatcaggcca tgtcttctccagagcccacatccatcctttctctatattgcctcccacagatgtgctaaa atttatttaactaatcctttatcctctatttgtgttgtctcccattttttattattacaa tattactgtggtgaacatgc > 35666_at HG-U95Av2 gaagaaggggccatcacaggatgccacccctgncntgggttgggnnnnnnnnnncacgac cagccccttcctgggtatttattctctatttattggggataggagaagaggcatcctgcc tgggtgggacagccccttcagccccttctcccctccccgcctggccanggcagggccacc ccactctacctccttagcttt cnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnn nnnnnagagctgacgggaggccccagctctgaggggagggggtccgtg gtanangcctggggccggtagaggctccccagggctcccttatgtccnnnnnnnnnnnnn nngggtgtggatgtaattagctctggggggcagttgggtagatgggtgggggctcctggt ggccttntgctgcccaggccacagccgcctttgggttccatcttgctaataaacactggc tctgggactagaaa > 35702_at HG-U95Av2 aggaatgtgccctggagatcatcaaagggggagctctgcgccaagaagaagtgtattatg acagctcactctggaccactcttctgatcagaaatccatgcaggaagatcctggaatttc tctactcaacgagctataatatggacagatteataaacaagtaggaactccctgagggct gggcatgctgagggattttgggactgttctgtctcatgtttatctgagctcttatctatg aagacatcttcccagagtgtccccagagacatgcaagtcatgggtcacacctgacaaatg gaaggagttcctctaacatttgcaaaatggaaatgtaataataatgaatgtcatgcaccg ctgcagccagcagttgtaaaattgt > 35724_at HG-U95Av2 acttcaaattggacccaggagccaaacattcccaacctatccctaaagggtggacaagct tcatttacacgatatctgnagatgtgtatattgggcccgatgatgcacaacaaaaaatag aacctcateacacageagtgcttggagaaggrgacagtgtccangtggagaacaaggatc ccaagagaagccactttgtcttaattgctggggagccattaagagaaccagttatccaac atggtccatttgtgatgaacaccaatgaagagatttctcaagctattcttgatttcagaa 84- 98677. doc 200533758 acgcaaaaaatgggtttgaaagggccaaaacctggaaatcaaagattgggaactagtgga aagcggaagagcaggtcttgatgtgtcctagaattttgccatttnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnaagcttatttagccggtgcttctaaagaattccacactaacg tgataacatggtttttgtaacaataaatgtaggatatttcctggc ^ catgcaaa > 35735_at HG-U95Av2 acacggtctatgagcaataatgtgatttctggacatngcccatgtataatcctcactgat gatttcaagctaangcaaaccacctnatacagagatctagaatctctttatgttctccag aggaaggtggaagaaaccatgggcaggagtaggaattgagtgataaacaattgggctaat gaagaaaacttctcttatnnnnnnnnnnnnnnnnattataacttcaatgggacactttag accattagacaattgacactggattaaacaaattcacataatgccaaatacacaatgtat ttatagcaacgtataatttgcaaagatggactttaaaagatgctgtgtaactaaactgaa ataattcaattacttattatttagaatgttaaagcttatgatagtcttttctaattctta acactcatacttgaaatctttctgagtttccccagaagagaatatgggattttttttgac atttttgacncatttaataatgctcttgtgtttacctagtatatgtagactttgtcttat gtgtcaaaagtcc > 35766_at HG-U95Av2 tgaggagagcaccacagtggtcaccnacacagtctgctgaggttggagctgctgagacga

cgctcacagagctgagacgtacagtccagtccttggagatcgacctggactccatgagaa atctgaaggccagcttggagaacagcctgagggaggtggaggcccnnntacgccctacag atggagcagctcaacgggatcctgctgcaccttgagtcagagctggcacagacccgggca gagggacagcgccaggcccaggagtatgaggccctgctgaacatcaaggtcaagctggan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggcgaggactttaatcttggtgat gccttggacagcagcaactccatgcaaaccatccaaaagaccaccacccgccggatagtg gatggcaaagtggtgtctgagaccaatgacaccaaagttctgaggc >35803_at HG-U95Av2 gtgtcattgctaaaacctcactgaacaganngcagccaaggtctgtgttcagcacttggt ctctgttgttacgtaaaataataagcatttaaaatagtttacagannnnntnnnnnngnn cnnttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntnnnnnnnnnn nnnnnnnnnnnnnnnc 111 c nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnntggcaggagagattaaggtaattacaacactcagttctatgtct tacaagcactttgtcttgtctctgcaagaaaattcgattccagtcatttcccataaaata cagacattttaccaacataatatgctttgattgatgcagcattatgctttgggcagtatt acaannnnnnnnnnnnnnnnnttctgtatttaaatattgtaaaaagaaaataagttataa ctgttataaagcagaacttttgttgcattttttaaactgttgaagtcactgtgtatgttt gtttggtcaatgtttccgc >35822_at HG-U95Av2 ggccagactatcaggcccatttgtctccccntgcaccgagggaacaactcgagcntttga ggcttncctccnaactaccacttgccagcaacaaaangnaagagctgctccctgcacagg atatcaaagctctgtttgtgtctgaggaggagaaaaagctgactcggaaggaggtnctac atcaagaatggggataagaaaggcagctgtgagagagatgctcaatatngccccaggcta tgacaaagtcaaggacatctcagaggtggtcancccctcggttccntttgtactggangg agtgagtnccctatgctgac c cnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnttcaagttggtgtaatcagctggggagtagtgga tgtctgcaaaaaccagaagcggcaaaagcaggtacctnntcacgcccgagactttcacat caacctctttcaagtgctgccctggctgaaggagaaactccaagatgaggatttgggttt tc >35824_at HG-U95Av2 tgaaaatggccttggagcattatctttagttacttgaagagtttctagtttttttaaaat acagtttatgttaaaataatttttattaatttagagaagacaatcaatgtctgtgagaaa acggactttcttttggattttctttttgtggtcattgtgagtgattgctttttccttttc ttagtttcacattcttcctttgttctaaaacttagactgacatetagctttgacaateat agtatgttttattttcctgagggggaataacttataatgctgtttagttttgtactattg gtgtgttggtgaatttttaaactgtgtgctaactgcaataaatt >35844_at HG-U95Av2 tacagtaaccacatgcggctgtttaaagttaagccaattaaaatcacataagattaaaaa 85- 98677.doc 200533758 ttnnnnnnnnnnnnnnnntaaccacgtttctagaggcgtcactgtatgtagttcatggct actgtactgacagcgagagcatgtccatctgttggacagcactattctagagaactaaac tggcttaacgagtcacagcctcagctgtgctgggacgacccttgtctccctgggtaggnn ngggggggaatgggggagggctnnatnngnccccagctggggcctgttgtctgggaccct ccctctcctgagaggggaggcctggtggcttagcctgggcaggtcgtgtctcctcctgac cccagtggctgcggtgaggggaaccaccctcccttgctgcaccagtggccattagctccc gtcaccactgcaacccagggtcccagctggctgggtcctcttctgcccccagtgcccttc cccttgggctgtgttggagtgagcacctcctctgtaggcacctctcacactgttgtc >35938_at HG-U95Av2 aggcagtttgcaatcccatgacaactggatttaaaagtacagtacagatagtcgtactga tcatgagagactggctgatacncaaagttgcagttacttagctgcatgagaataatacta ttataagttaggttgacaaatgatgttgattatgtaaggatatacttagctacattttca gtcagtatgaacttcctgatacaaatgtagggatatatactgtatttttaaacatttctc accaactttcttatgtgtgttctttttaaaaattttttttcttttaaaatatttaacagt tcaatctcaataagacctcgcattatgtatgaatgtta >35966__at HG-U95Av2 ccatttttaagaagaggtgttccagttctgcatctgataccgtctcctttccctgaagtccgctcacagagctgagacgtacagtccagtccttggagatcgacctggactccatgagaa atctgaaggccagcttggagaacagcctgagggaggtggaggcccnnntacgccctacag atggagcagctcaacgggatcctgctgcaccttgagtcagagctggcacagacccgggca gagggacagcgccaggcccaggagtatgaggccctgctgaacatcaaggtcaagctggan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggcgaggactttaatcttggtgat gccttggacagcagcaactccatgcaaaccatccaaaagaccaccacccgccggatagtg gatggcaaagtggtgtctgagaccaatgacaccaaagttctgaggc > 35803_at HG-U95Av2 gtgtcattgctaaaacctcactgaacaganngcagccaaggtctgtgttcagcacttggt ctctgttgttacgtaaaataataagcatttaaaatagtttacagannnnntnnnnnngnn cnnttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntnnnnnnnnnn nnnnnnnnnnnnnnnc 111 c nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnntggcaggagagattaaggtaattacaacactcagttctatgtct tacaagcactttgtcttgtctctgcaagaaaattcgattccagtcatttcccataaaata cagacattttaccaacataatatgctttgattgatgcagcattatgctttgggcagtatt acaannnnnnnnnnnnnnnnnttctgtatttaaatattgtaaaaagaaaataagttataa ctgttataaagcagaacttttgttgcattttttaaactgttgaagtcactgtgtatgttt gtttggtcaatg tttccgc > 35822_at HG-U95Av2 ggccagactatcaggcccatttgtctccccntgcaccgagggaacaactcgagcntttga ggcttncctccnaactaccacttgccagcaacaaaangnaagagctgctccctgcacagg atatcaaagctctgtttgtgtctgaggaggagaaaaagctgactcggaaggaggtnctac atcaagaatggggataagaaaggcagctgtgagagagatgctcaatatngccccaggcta tgacaaagtcaaggacatctcagaggtggtcancccctcggttccntttgtactggangg agtgagtnccctatgctgac c cnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnttcaagttggtgtaatcagctggggagtagtgga tgtctgcaaaaaccagaagcggcaaaagcaggtacctnntcacgcccgagactttcacat caacctctttcaagtgctgccctggctgaaggagaaactccaagatgaggatttgggttt tc > 35824_at HG-U95Av2 tgaaaatggccttggagcattatctttagttacttgaagagtttctagtttttttaaaat acagtttatgttaaaataatttttattaatttagagaagacaatcaatgtctgtgagaaa acggactttcttttggattttctttttgtggtcattgtgagtgattgctttttccttttc ttagtttcacattcttcctttgttctaaaacttagactgacatetagctttgacaateat agtatgttttattttcctgagggggaataacttataatgctgtttagttttgtactattg gtgtgttggtgaatttttaaactgtgtgctaactgcaataaatt > 35844_at HG-U95Av2 tacagtaaccacatgcggc tgtttaaagttaagccaattaaaatcacataagattaaaaa 85- 98677.doc 200533758 ttnnnnnnnnnnnnnnnntaaccacgtttctagaggcgtcactgtatgtagttcatggct actgtactgacagcgagagcatgtccatctgttggacagcactattctagagaactaaac tggcttaacgagtcacagcctcagctgtgctgggacgacccttgtctccctgggtaggnn ngggggggaatgggggagggctnnatnngnccccagctggggcctgttgtctgggaccct ccctctcctgagaggggaggcctggtggcttagcctgggcaggtcgtgtctcctcctgac cccagtggctgcggtgaggggaaccaccctcccttgctgcaccagtggccattagctccc gtcaccactgcaacccagggtcccagctggctgggtcctcttctgcccccagtgcccttc cccttgggctgtgttggagtgagcacctcctctgtaggcacctctcacactgttgtc > 35938_at HG-U95Av2 aggcagtttgcaatcccatgacaactggatttaaaagtacagtacagatagtcgtactga tcatgagagactggctgatacncaaagttgcagttacttagctgcatgagaataatacta ttataagttaggttgacaaatgatgttgattatgtaaggatatacttagctacattttca gtcagtatgaacttcctgatacaaatgtagggatatatactgtatttttaaacatttctc accaactttcttatgtgtgttctttttaaaaattttttttcttttaaaatatttaacagt tcaatctcaataagacctcgcattatgtatgaatgtta > 35966__at HG-U95Av2 ccatttttaagaagaggtgttccagttctgcatctgataccgtctcctttccctgaag tc

tggcacaccatggatgacaatgaagaaaatttggatgaatcaaccattgacaatctaaac aaaatcctacaagtctttgtgttggaatatcttcatttgtaatactctgatttagtttag gataattggttctagaattgaattcaaaagtcaaggcatcatttaaaataatctgatttc agacaaatgctgtgtggaaacatctatcctatagatcatcctattcttatgtgtctttgg ttatcagatcaattacagaataattgtgttgtganannnnnnnnnaaattgctcattaat ttttatttacagattgaaaaagaggcaccgtgtaaagaaaatggcaaaataaatatcttt ccannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggaannangtagcc ttnnnnattttatgattttttcatatgtggaaatctattacatgtaatacaaaacaaaca tgtagtttgaaggcggtcagatttctttgagaaatc >35992_at HG-U95Av2 tggagacacacttcccagatcaccgcanngnnnnnnnnnnnnnnnnngntctnggncgtt cnggcntncctgccgggtggcttcttcaatcccgtctccttcccaagctcccggcttttt ctaatcaggcaggcgtctgtcaaccctctcnncnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnntgcgccaacctgtgtggggtcttcttcgggcctccctctccgccncgctcctgctc ctacctgcagcacccccagctccgactccagactctctgcatcaggtctccccactccac gctccgggcgccccaactccaacaccacgtcctgncgcgcaggttctnncccnngcggag gagcgcgcagggtgggcggcttaccatagcaagtgatcctgcgatagggaacgcgccctt gccccgaggctgcactaccacaggaaataac >36057_at HG-U95Av2 aaattctgattggttatgtaccgtcaaaagacttgaagaaatttcatgattttgcagtgt ggaagcgttgaaaattgaaagttactgcttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnaatgtatcatccagagtgatgttatctgtgacagtcaeca gctttaagctgaaccattttatgaataccaaataaatagacctcttgtactgaaaacata tttgtgactttaatcgtgctgcttggatagaaatatttttactggttcttctgaattgac agtaaacctgtccattatgaatggcctactgttctattattt >36059__at HG-U95Av2 gaaggatcttattgcacttgggctgttcagaatgtagaaaggacatatttgaggaagtat ctatttgagcactgatttactctgtaaa annnnnnnnnnnnnnnnnnt a aa c t annnnnn nnnnnnnnnnnnnnnnnnnntgtaatggttttaacgttactcactggagagattggactt tctggagttatttaaccactatgttcagtattttaggactttatgataatttaatataaa tttagcttttcttaatcannnnnnnnnnnnnnnannnatgactaatcctgcacctgctct gtctggcagacccatgctgtggaaaacctgcttacagacatcacttttaagtcctttgtg gatgtgggcacagtgaagagcaataaanantgtgaggttcctgntggagttttcagetea tctggagaagacaggtcgaaggccagagttccttgactgatgaaacctttatttcctctg gaagaaggaatgggtagatggggtttcctctttgagttgc >36065_at HG-U95Av2 ggcccagcaaggtaatttatggttgagctgatgtcaattggttctngtcttgagtcgact caatttagcccaagtgctgaaacaagaaatgtcatttttttcatcaaagacaccagggca -86 - 98677.doc 200533758 gatttttaagtaaagaaagacaattggacccttaagaatttatgcatttgtaaagttgct gttgatccaaatattttcaagccatgtaatccattggttttgtgggcagtttaataaacc tgaacctttgtgtgttttctaattgtacctgagttgaccatcctttctttttatagtata tttcttgtatgatattttgtaaagctctcacctggttcttttatggggacttttcgtttt tgggcaactccagtgtatttatgtgaaactttataagagaattaatttttccatttgcat attaatatgttcctccacacatgtaaaggcacagtggctccgtgtg >36103_at HG-U95Av2 agcaggagcctgagccttgggaacatgcgtgtgacctccacagctacctcttctatggac tggtnnnnnnnnnnnnnnnncactgtgggactcttcttaacttaaattttaatttattta tactatttagtttttgtaatttattttcgatttcacagtgtgtttgtgattgtttgctct gagagttcccctgtcccctccncnttccctcacanngngtctggtgacnnnnnnnnnnnn nnnnnnnnnnnnngtaggcagtcatggcaccaaagccaccagactgacaaatgtgtatcg gatgcttttgttcagggctgtgatcggcctggggaaataata >36149_at HG-U95Av2 tgggcagccagcattcattgtaagttccctctttgaaaactggtgtgtgggtgttcagtt ctgtgtctggtgggtatggacagacagtaatctcctgtgatctgtgctagctgtgaggca gctctggaannnnnnnnnnnnnnnggtttgaaccgtgaacaaaactgtgttttgagtttatggcacaccatggatgacaatgaagaaaatttggatgaatcaaccattgacaatctaaac aaaatcctacaagtctttgtgttggaatatcttcatttgtaatactctgatttagtttag gataattggttctagaattgaattcaaaagtcaaggcatcatttaaaataatctgatttc agacaaatgctgtgtggaaacatctatcctatagatcatcctattcttatgtgtctttgg ttatcagatcaattacagaataattgtgttgtganannnnnnnnnaaattgctcattaat ttttatttacagattgaaaaagaggcaccgtgtaaagaaaatggcaaaataaatatcttt ccannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggaannangtagcc ttnnnnattttatgattttttcatatgtggaaatctattacatgtaatacaaaacaaaca tgtagtttgaaggcggtcagatttctttgagaaatc > 35992_at HG-U95Av2 tggagacacacttcccagatcaccgcanngnnnnnnnnnnnnnnnnngntctnggncgtt cnggcntncctgccgggtggcttcttcaatcccgtctccttcccaagctcccggcttttt ctaatcaggcaggcgtctgtcaaccctctcnncnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnntgcgccaacctgtgtggggtcttcttcgggcctccctctccgccncgctcctgctc ctacctgcagcacccccagctccgactccagactctctgcatcaggtctccccactccac gctccgggcgccccaactccaacaccacgtcctgncgcgcaggttctnncccnngcggag gagcgcgcagggtgggcggcttaccatagcaagtgatcctgcgatagggaacgcgccctt gccccgaggctgcactaccacagga aataac > 36057_at HG-U95Av2 aaattctgattggttatgtaccgtcaaaagacttgaagaaatttcatgattttgcagtgt ggaagcgttgaaaattgaaagttactgcttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnaatgtatcatccagagtgatgttatctgtgacagtcaeca gctttaagctgaaccattttatgaataccaaataaatagacctcttgtactgaaaacata tttgtgactttaatcgtgctgcttggatagaaatatttttactggttcttctgaattgac agtaaacctgtccattatgaatggcctactgttctattattt > 36059__at HG-U95Av2 gaaggatcttattgcacttgggctgttcagaatgtagaaaggacatatttgaggaagtat ctatttgagcactgatttactctgtaaa annnnnnnnnnnnnnnnnnt a aa c t annnnnn nnnnnnnnnnnnnnnnnnnntgtaatggttttaacgttactcactggagagattggactt tctggagttatttaaccactatgttcagtattttaggactttatgataatttaatataaa tttagcttttcttaatcannnnnnnnnnnnnnnannnatgactaatcctgcacctgctct gtctggcagacccatgctgtggaaaacctgcttacagacatcacttttaagtcctttgtg gatgtgggcacagtgaagagcaataaanantgtgaggttcctgntggagttttcagetea tctggagaagacaggtcgaaggccagagttccttgactgatgaaacctttatttcctctg gaagaaggaatgggtagatggggtttcctctttgagttgc > 36065_at HG-U95Av2 ggcccagcaaggtaatttatggttgagctgatgtcaattg gttctngtcttgagtcgact caatttagcccaagtgctgaaacaagaaatgtcatttttttcatcaaagacaccagggca -86 - 98677.doc 200533758 gatttttaagtaaagaaagacaattggacccttaagaatttatgcatttgtaaagttgct gttgatccaaatattttcaagccatgtaatccattggttttgtgggcagtttaataaacc tgaacctttgtgtgttttctaattgtacctgagttgaccatcctttctttttatagtata tttcttgtatgatattttgtaaagctctcacctggttcttttatggggacttttcgtttt tgggcaactccagtgtatttatgtgaaactttataagagaattaatttttccatttgcat attaatatgttcctccacacatgtaaaggcacagtggctccgtgtg > 36103_at HG-U95Av2 agcaggagcctgagccttgggaacatgcgtgtgacctccacagctacctcttctatggac tggtnnnnnnnnnnnnnnnncactgtgggactcttcttaacttaaattttaatttattta tactatttagtttttgtaatttattttcgatttcacagtgtgtttgtgattgtttgctct gagagttcccctgtcccctccncnttccctcacanngngtctggtgacnnnnnnnnnnnn nnnnnnnnnnnnngtaggcagtcatggcaccaaagccaccagactgacaaatgtgtatcg gatgcttttgttcagggctgtgatcggcctggggaaataata > 36149_at HG-U95Av2 tgggcagccagcattcattgtaagttccctctttgaaaactggtgtgtgggtgttcagtt ctgtgtctggtgggtatggacagacagtaatctcctgtgatctgtgctagctgtgaggca gctctggaannnnnnnnnnnnnnn ggtttgaaccgtgaacaaaactgtgtttgagttta

gctgacattaaagaaaaaagttcatcacgtgactgttaatgtaaacctggttattaaaat aactatgaaattannaaaaaaaaaaaaaaaaannnaaaannnnnnnnnatttaaaacagg agaaatctggtaagttgttaggnttctaaattccttttagtctgttcactgagatattaa atttcagtagacagaacccaaaaagagatttcatttctttctaatcactttggcttctnt ctnttttnttaagtaggtaaaaaccttccttggtgggcacctaagcaggatgcagccaat tagttcatgaacccagctgcgga >36156_at HG-U95Av2 taagtcctttcaattccaccagggccagagcagctccaccactgtgcacttagccatgat ggcaacagaaaccaagagacacaattacgcaggtatttagaagcagagggacaaccagaa ggcccttaactatcaccagtgcatcacatctgcacactctcttctccattccctagcagg aacttctagctcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnntttcagctagacaatg atttggccaggcctagtaaccaaggccctgtctctggctactccctggaccacgaggctg attcctctcatttccagcttctcagtttctgcctgggcaatgnccaggggccaggagtgg ggagagttgtgatggaggggagaggggtcacacccaccccctgcctggttnntaggctgc tgcacaccaaggccctgcatctgtctgctctgcat >36175_s_at HG-U95Av2 tagagcttggttatcggccggcccggtggnttggcaggcagtgctgtgcgctnntcnatg gagaagacctgggcttagcaatctccttagttcttgctacacaggatggtgactggaact aaggctacacagagggtcgcacttggactctganggttgggtgtggaagggggaaaaggg gatggagacctgctnccccagctcttcctgtcagccggtttancatgggaancagggtta ancatctgtgttnaggggaggtncaccttaccctttttcataggggaagagtgtcacact cctggctatctcagggggaatggggaaaagaatctttcaagggcaaagaactcgtgggag gatgtctgttgtatgtaatactcacaatggcttttggttagtgttgaaggtgggaagagc atttgtaggtccagaagagtgaaagagagggaggggtgcagcaacatgtgcacaggcacg cacanntntgcacgcacacatacaatctgggttatctttgtgctat >36215_at HG-U95Av2 gtctgatcgatcatgcagatacaatgttggtatttgagaggttagtttttttncctacac ttttttttgccaactgacttaacaacattgctgtcaggtggaaatttcaagcacttntgc acatttagttcagtgtttgttgagaatccatggcttaacccacttgttttgctatttttt tctttgcttttaattttccccatctgattttatctctgcgtttcagtgacctaccttaaa acaacacacgagaagagttaaactgggttcattttaatgatcaatttacctgcatataaa atttatttttaatcaagctgatcttaatgtatataatcattctatttgctttnnnnnnnn nnnnnnnnnnnnnnnaacaccacttcttttcatctgtaccacaccctggtgaaacctttg aagacataaaaaaaacctgtctgagatgttctttctaccaatctatatgtctttcggttn nnnnnnnnnnnnnnnnnnnnnnnnnnngtaaatgctgatattgatttcactggtccatct atatttaaaacgtgcaagaaaaaaataaaatactctgctctagcaagttttgtg >36227_at HG-U95Av2 taccaaaaccagtgaagtgtaagaaacccagactgaacttaccgtgagcgacaaagatga 87- 98677.doc 200533758 tttaaaagggaagtctagagttcctagtctccctcacagcacagagaagacaaaattagc aaaaccccactacacagtctgcaagattctgaaacattgctttgaccactcttcctgagt tcagtggcactcaacatgagtcaagagcatcctgcttctnnnnnnnnnnnnnnnnnnnnn ngtttaaggtgacccaatgattcagcta >3 62 33_at HG-U95Av2 ctgaaaccaagaaggatctgtatgaacccactcatgggggcaaggtcttgagcatggccc ctgnnctcacctctgtggaaatcattccattccgagtggctgcctacaacaaagccaaaa aagccatggacttctatgatccagcaaggcacaatgagtttgacttcatctcaggaactc gaatgaggaagctcgcccgggaaggnnnnnnnnnnnnnnnnnnnnnnnnnnnccccaaag catggaaggtcctgacagattattacaggtccctggagaagaactaagcctttggnncca gagtttctttctgaagtgctct >36314_at HG-U95Av2 aacttctcccggtgcctggagctgcagtgtcagcccgactcctcaaccntgccaccccca tggagtccccggcccctggaggccacagccccgacagccccgcagccccctctgctcctc ctactgctgctgcccgtgggcctcctgctgctggcngctgcnnnnnnnnnnnnnnnncag aggacgcggcggaggacaccccgccctggggagcaggtgccccccgtccccagtccccag gacctgctgcttgtggagcactgacctggccaaggcctcatcctnnnnnnnnnnnnnnnngctgacattaaagaaaaaagttcatcacgtgactgttaatgtaaacctggttattaaaat aactatgaaattannaaaaaaaaaaaaaaaaannnaaaannnnnnnnnatttaaaacagg agaaatctggtaagttgttaggnttctaaattccttttagtctgttcactgagatattaa atttcagtagacagaacccaaaaagagatttcatttctttctaatcactttggcttctnt ctnttttnttaagtaggtaaaaaccttccttggtgggcacctaagcaggatgcagccaat tagttcatgaacccagctgcgga > 36156_at HG-U95Av2 taagtcctttcaattccaccagggccagagcagctccaccactgtgcacttagccatgat ggcaacagaaaccaagagacacaattacgcaggtatttagaagcagagggacaaccagaa ggcccttaactatcaccagtgcatcacatctgcacactctcttctccattccctagcagg aacttctagctcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnntttcagctagacaatg atttggccaggcctagtaaccaaggccctgtctctggctactccctggaccacgaggctg attcctctcatttccagcttctcagtttctgcctgggcaatgnccaggggccaggagtgg ggagagttgtgatggaggggagaggggtcacacccaccccctgcctggttnntaggctgc tgcacaccaaggccctgcatctgtctgctctgcat > 36175_s_at HG-U95Av2 tagagcttggttatcggccggcccggtggnttggcaggcagtgctgtgcgctnntcnatg gagaagacctgggcttagcaatctccttagttcttgctacacaggatggtgactggaact aaggctacacagagggtcgcacttggactctganggtt gggtgtggaagggggaaaaggg gatggagacctgctnccccagctcttcctgtcagccggtttancatgggaancagggtta ancatctgtgttnaggggaggtncaccttaccctttttcataggggaagagtgtcacact cctggctatctcagggggaatggggaaaagaatctttcaagggcaaagaactcgtgggag gatgtctgttgtatgtaatactcacaatggcttttggttagtgttgaaggtgggaagagc atttgtaggtccagaagagtgaaagagagggaggggtgcagcaacatgtgcacaggcacg cacanntntgcacgcacacatacaatctgggttatctttgtgctat > 36215_at HG-U95Av2 gtctgatcgatcatgcagatacaatgttggtatttgagaggttagtttttttncctacac ttttttttgccaactgacttaacaacattgctgtcaggtggaaatttcaagcacttntgc acatttagttcagtgtttgttgagaatccatggcttaacccacttgttttgctatttttt tctttgcttttaattttccccatctgattttatctctgcgtttcagtgacctaccttaaa acaacacacgagaagagttaaactgggttcattttaatgatcaatttacctgcatataaa atttatttttaatcaagctgatcttaatgtatataatcattctatttgctttnnnnnnnn nnnnnnnnnnnnnnnaacaccacttcttttcatctgtaccacaccctggtgaaacctttg aagacataaaaaaaacctgtctgagatgttctttctaccaatctatatgtctttcggttn nnnnnnnnnnnnnnnnnnnnnnnnnnngtaaatgctgatattgatttcactggtccatct atatttaaaacgtgcaagaaaaaaataaaatactctgctctagcaagttttgt g > 36227_at HG-U95Av2 taccaaaaccagtgaagtgtaagaaacccagactgaacttaccgtgagcgacaaagatga 87- 98677.doc 200533758 tttaaaagggaagtctagagttcctagtctccctcacagcacagagaagacaaaattagc aaaaccccactacacagtctgcaagattctgaaacattgctttgaccactcttcctgagt tcagtggcactcaacatgagtcaagagcatcctgcttctnnnnnnnnnnnnnnnnnnnnn ngtttaaggtgacccaatgattcagcta > 3 62 33_at HG-U95Av2 ctgaaaccaagaaggatctgtatgaacccactcatgggggcaaggtcttgagcatggccc ctgnnctcacctctgtggaaatcattccattccgagtggctgcctacaacaaagccaaaa aagccatggacttctatgatccagcaaggcacaatgagtttgacttcatctcaggaactc gaatgaggaagctcgcccgggaaggnnnnnnnnnnnnnnnnnnnnnnnnnnnccccaaag catggaaggtcctgacagattattacaggtccctggagaagaactaagcctttggnncca gagtttctttctgaagtgctct > 36314_at HG-U95Av2 aacttctcccggtgcctggagctgcagtgtcagcccgactcctcaaccntgccaccccca tggagtccccggcccctggaggccacagccccgacagccccgcagccccctctgctcctc ctactgctgctgcccgtgggcctcctgctgctggcngctgcnnnnnnnnnnnnnnnncag aggacgcggcggaggacaccccgccctggggagcaggtgccccccgtccccagtccccag gacctgctgcttgtggagcactgacctggccaaggcctcatcctnnnnnnnnnnnnnn nn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnncccttccttgggcccctctcattccctccccagaatggaggcaacgccaga atccagcaccggccccanttacccaactctgtacaaagcccttgtccccatgaaattgta ta >36344_at HG-U95Av2 tttgcctgagcagctcttggtgggagacatgttcaattacttcctctctctggccattgg ggtctttctgttcccagccttcctcacagcctcnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnncttctgccatggatgaaaactcagagaagaaaaggaagagggccatcaaactcat tgtcactgtcctggccatgtacctgatctgcttcactcctagtaaccttctgcttgtggt gcattattttctgattaanagccagggccagagccatgtctatgccctgtacattgtagc cctctgcctctctacccttaacagctgcatcgacccctttgtctattnnnnnnnnnnnnn nnnnnnnnnnnnnnnngcaaagaacgctctcctttgccgaagtgtccgcactgtaaagca gatgcaagtatccctcacctcaaagaaacactccaggaaatccagctcttactcttcaag ttcaaccactgttaagacctcctattgag >36345_g_at HG-U95Av2 tgttaagacctcctattgagttttccaggtcctcagatgggaattgcacagtaggatgtg gaacctgtttaatgttatgaggacgtgtctgttatttcctaatcaaaaagg >36377_at HG-U95Av2 ggcgaaagatatctctccattgtgcatctgcctcttttgacgttggaagacacatgtctt actccccaaagggagcccagcactgggagccttcttgatgatctcaaaaataatagctat tcaagaaaatcaccaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntg ggagcaacatgaatgttctacaaaagtttaaagcagagattgtttcaaatgggtgtagta gatattactgaaaaccaaaaaagagtgagattgtcagtgtaagaatgtgatttaatgttt gtagtgcttacaattttgtgtaccaactggatgactaaaaagagtaaaataatttaatta atagctcatattttatgtgtgaaaacatgttagtgaacatatataatcaaaatagatttc attgctattgcatagtc >36445_at HG-U95Av2 cagtacttctggacatgctctggaggagaaagattggtcctcagatgaccctttctcatg ctgcaggattccatgctactag >36543_at HG-U95Av2 gggtgcatttctaggacttttctaacatatgtctataatatagtgtttaggttctttttt ttttcaggaatacatttggaaattcaaaacaattggcaaactttgtattaatgtgttaag tgcaggagacattnnnnnnnnnnnnnnnnnnctaatatgctttacaatctgcactttaac tgacttaagtggcattaaacatttgagagctaactatatttttataagactactatacaa actacagagtttatgatttaaggtdcttaaagcttctatggttgdcdttg >36550 at HG-U95Av2 88- 98677.doc 200533758 ggaaccacctatgcttaaaatactgtaaatatgcantgaggtttggcaaaatctattcca tgtgtgatttgcttgtagaaacaattttgaaagccccttgaggaaaataaaaatcaagaa gaacacttttctcccttttccatacaaattaaaacttaacagcatcaaattattgggacc agaaaccaagtaatgtataatgtggcttttgttgagttaaataagatgctatataatgga gaagaatttgaaaatgcacaaaaaaatcaatctacattatcagnnnnnnnnnnnnnnnnn nnnntatgttaaatannnnnnnnnnnnnnnnnnnnnaactatgagggtcttgtatccacg taacacaggtagttacaaaaacatgttattgtactgtgtaaagatgcatagtcatctcat ttggttggctttgtaccttgtaccttttttagccttggcttttgttgaactagaaccctc agca >36564_at HG-U95Av2 gcaccgagcccaagtgcccatatgaacctctctgccctagccgagggacaaactgtnnnn nnnnnnnnnnnnnnnnnnnnnnagagtatgaagtggaatgaatgctcctgttctgagaag cacacttgtaactgcatcttttgga >36578___at HG-U95Av2 tatgccaggaatgtgccccttctctaagaaaatgccctatttgcaggggtataatcaagg gtactgttcgtacatttctctcttaaagaaaaatagtctatattttaacctgcataaaaa ggtctttaaaatattgttgaacacttgaagccatctaaagtaaaaagggaattatgagttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnncccttccttgggcccctctcattccctccccagaatggaggcaacgccaga atccagcaccggccccanttacccaactctgtacaaagcccttgtccccatgaaattgta ta > 36344_at HG-U95Av2 tttgcctgagcagctcttggtgggagacatgttcaattacttcctctctctggccattgg ggtctttctgttcccagccttcctcacagcctcnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnncttctgccatggatgaaaactcagagaagaaaaggaagagggccatcaaactcat tgtcactgtcctggccatgtacctgatctgcttcactcctagtaaccttctgcttgtggt gcattattttctgattaanagccagggccagagccatgtctatgccctgtacattgtagc cctctgcctctctacccttaacagctgcatcgacccctttgtctattnnnnnnnnnnnnn nnnnnnnnnnnnnnnngcaaagaacgctctcctttgccgaagtgtccgcactgtaaagca gatgcaagtatccctcacctcaaagaaacactccaggaaatccagctcttactcttcaag ttcaaccactgttaagacctcctattgag > 36345_g_at HG-U95Av2 tgttaagacctcctattgagttttccaggtcctcagatgggaattgcacagtaggatgtg gaacctgtttaatgttatgaggacgtgtctgttatttcctaatcaaaaagg > 36377_at HG-U95Av2 ggcgaaagatatctctccattgtgcatctgcctcttttgacgttggaagacacatgtctt actccccaaagggagcccagcactgggagccttcttgatgatctcaaaaat aatagctat tcaagaaaatcaccaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntg ggagcaacatgaatgttctacaaaagtttaaagcagagattgtttcaaatgggtgtagta gatattactgaaaaccaaaaaagagtgagattgtcagtgtaagaatgtgatttaatgttt gtagtgcttacaattttgtgtaccaactggatgactaaaaagagtaaaataatttaatta atagctcatattttatgtgtgaaaacatgttagtgaacatatataatcaaaatagatttc attgctattgcatagtc > 36445_at HG-U95Av2 cagtacttctggacatgctctggaggagaaagattggtcctcagatgaccctttctcatg ctgcaggattccatgctactag > 36543_at HG-U95Av2 gggtgcatttctaggacttttctaacatatgtctataatatagtgtttaggttctttttt ttttcaggaatacatttggaaattcaaaacaattggcaaactttgtattaatgtgttaag tgcaggagacattnnnnnnnnnnnnnnnnnnctaatatgctttacaatctgcactttaac tgacttaagtggcattaaacatttgagagctaactatatttttataagactactatacaa actacagagtttatgatttaaggtdcttaaagcttctatggttgdcdttg > 36550 at HG-U95Av2 88- 98677.doc 200533758 ggaaccacctatgcttaaaatactgtaaatatgcantgaggtttggcaaaatctattcca tgtgtgatttgcttgtagaaacaattttgaaagccccttgaggaaaataaaaatcaagaa gaacacttttctcccttttccatacaaattaaaacttaacagcatcaaattattgggacc agaaaccaagta atgtataatgtggcttttgttgagttaaataagatgctatataatgga gaagaatttgaaaatgcacaaaaaaatcaatctacattatcagnnnnnnnnnnnnnnnnn nnnntatgttaaatannnnnnnnnnnnnnnnnnnnnaactatgagggtcttgtatccacg taacacaggtagttacaaaaacatgttattgtactgtgtaaagatgcatagtcatctcat ttggttggctttgtaccttgtaccttttttagccttggcttttgttgaactagaaccctc agca > 36564_at HG-U95Av2 gcaccgagcccaagtgcccatatgaacctctctgccctagccgagggacaaactgtnnnn nnnnnnnnnnnnnnnnnnnnnnagagtatgaagtggaatgaatgctcctgttctgagaag cacacttgtaactgcatcttttgga > 36578 ___ at HG-U95Av2 tatgccaggaatgtgccccttctctaagaaaatgccctatttgcaggggtataatcaagg gtactgttcgtacatttctctcttaaagaaaaatagtctatattttaacctgcataaaaa ggtctttaaaatattgttgaacacttgaagccatctaaagtaaaaagggaattatgagtt

tttcaattagtaacattcatgttctagtctgctttggtactaataatctnnnnnnnnnnn nnnnnnnntcatatatttaatcttaatctgtttatttacaagggaagatttatgtttggt gaactatattagtatgtatgtgtacctaagggagtagtnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnactggatttgttgttctttcagaaagctttgaatactaaattatagtgt agaaaagaactggaaaccaggaactctggagttcatcagagttatggtgccgaattgtct ttggtgcttttcacttgtgttttaaaataaggatttttctcttatttctccccctagttt gtgagaaacatctcaataaagtgctt >36600_at HG-U95Av2 cagatacctcggattgaggatggtaacaattttnggagtggctgtccaggagaaggtgtt tgagctgatgaccagcctccacaccaagnctagaaggcttccacactcaaatctctaagt atttctctgagcgtggtgatgcagtgactaaagcagccaagcagccccatgtnnnnnnnn nnnnnnngctggtgcacgagctggatgaggcagagtaccgggacatccggctgatggtca tggagatccgcaatgcttatgctgtgttatatgacatcatcctgaagaacttcgagaagc tcaagaagcccaggggagaaacaaagggaatgatctattgagagccctctctcccannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntggnnnnnnnnnnnnnnnnncaaac ttgcttctgttgagatttttccctcac >36658_at HG-U95Av2 gaccttatccacaacccggggcttggaaaggaaggtattttggaatcacaccctccggtt atgttgctccagtaaaatctnnnnnnnnnnnnnnnnnnnnttcttagcatggtgagctga gttcatggcttttttttgtagccagtcctgtccctggnccatccatgtgatggttttgga tggagttaaacttgnatgccagtgggcagtgcatgtggaaagtatcagagtaagncnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnanggttttctttagaatcagaattgta gccagtttctttggccagaaggatgaatacttggatattactgaaagggaggggtggaga tgggtgtggcagtgtatggtgtgtgatttttattttcttctttggtcatgggggccaagg agaaaggcatgaatcttccctgtcaggctcttacanccacaggcactgtgtctactgtct g >36659_at HG-U95Av2 acagacgagacaacagcacacaggcagccagccgtnggccagaggntcgaggggnnctca ggggcntcaggcnacccgtnccccacacganngggccccgtngggtgggcctnggccctn gctttnctacngnccaatgttatgnccagctnccatgttctncccaaataccngttgnat gtgaattattttaaaggcaaaacngtgctctttannttttanaaaacactgataatcaca ctgcggtaggtcattcttttgccacatccctatagaccactgggtttggcaaaactcagg cagaagtggagaccnttctagacatcantgtcagccttgctacttgaaggtacaccccat agggtcggaggtgctgtccccactgccccacnttgtccctgagatttaacccctccactg ctgggggtgagctgtactcttctgactgc >36690_at HG-U95Av2 gactattttcaagcaacctggtccacccaggattagtgaccaggttttcaggaaaggatt tgcttctctctagaaaatgtctgaaaggattttattttnnnnnnnnnnnnnnnnngaaaa -89- 98677.doc 200533758 taccctcctcaaataacttgcttaactacatatagattcaagtgtgtcaatattctattt tgtatattaaatgctatataatggggacaaatctatattatactgtgtatggcattatta agaagctttttcattattttttatcacagtaattttaaaatgtgtaaaaattaaaaccag tgactcctgtttaaaaataaaagntgtagttttttatteatgetgaataataatctgtag ttaaaaaaaaagtgtnnnnnnnnnnnnnnnntgaaatgtcagactgtaaaaccttgtgtg gaaatgtttaacttttattttttcatttaaatttgctgttctggtattacc >36691_at HG-U95Av2 cttcagcgccactggctggaaggtgggctgggtcctgggtccagatcacatcatgaagca cctgcggaccgtgcaccagaactccgtcttccactgccccacgcagagccaggctgcagt agccgagagctttgaacgggagcagctgctcttccgccaacccagcagctactttgtgca gttcccgcaggccatgcagcgctgccgtgaccacatgatacgtagcctacagtcagtggg cctgaagcccatcatccctcagggcagctactteeteatcacagacatctcagacttcaa gaggaagatgcctgacttgcctggagctgtggatgagccctatgacagacgcttcg >3 67 00__at HG-U95Av2 tacaaactgtgacctcagcttcagagtgtcagggcctcacttgtatagaatgtaatgttc tcctcaaacatttatgttaactctataaacaaatatcgttaagttadacdidgttttcaaa aacaaaacaatttttaaagtaccttaaaattgaggatgttactcagtgttaacacatgggtttcaattagtaacattcatgttctagtctgctttggtactaataatctnnnnnnnnnnn nnnnnnnntcatatatttaatcttaatctgtttatttacaagggaagatttatgtttggt gaactatattagtatgtatgtgtacctaagggagtagtnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnactggatttgttgttctttcagaaagctttgaatactaaattatagtgt agaaaagaactggaaaccaggaactctggagttcatcagagttatggtgccgaattgtct ttggtgcttttcacttgtgttttaaaataaggatttttctcttatttctccccctagttt gtgagaaacatctcaataaagtgctt > 36600_at HG-U95Av2 cagatacctcggattgaggatggtaacaattttnggagtggctgtccaggagaaggtgtt tgagctgatgaccagcctccacaccaagnctagaaggcttccacactcaaatctctaagt atttctctgagcgtggtgatgcagtgactaaagcagccaagcagccccatgtnnnnnnnn nnnnnnngctggtgcacgagctggatgaggcagagtaccgggacatccggctgatggtca tggagatccgcaatgcttatgctgtgttatatgacatcatcctgaagaacttcgagaagc tcaagaagcccaggggagaaacaaagggaatgatctattgagagccctctctcccannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntggnnnnnnnnnnnnnnnnncaaac ttgcttctgttgagatttttccctcac > 36658_at HG-U95Av2 gaccttatccacaacccggggcttggaaaggaaggtattttggaatcacaccctccggtt atgttgctccagtaaaatctnnnnnnnnnnnnnnnnnnnnttctt agcatggtgagctga gttcatggcttttttttgtagccagtcctgtccctggnccatccatgtgatggttttgga tggagttaaacttgnatgccagtgggcagtgcatgtggaaagtatcagagtaagncnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnanggttttctttagaatcagaattgta gccagtttctttggccagaaggatgaatacttggatattactgaaagggaggggtggaga tgggtgtggcagtgtatggtgtgtgatttttattttcttctttggtcatgggggccaagg agaaaggcatgaatcttccctgtcaggctcttacanccacaggcactgtgtctactgtct g > 36659_at HG-U95Av2 acagacgagacaacagcacacaggcagccagccgtnggccagaggntcgaggggnnctca ggggcntcaggcnacccgtnccccacacganngggccccgtngggtgggcctnggccctn gctttnctacngnccaatgttatgnccagctnccatgttctncccaaataccngttgnat gtgaattattttaaaggcaaaacngtgctctttannttttanaaaacactgataatcaca ctgcggtaggtcattcttttgccacatccctatagaccactgggtttggcaaaactcagg cagaagtggagaccnttctagacatcantgtcagccttgctacttgaaggtacaccccat agggtcggaggtgctgtccccactgccccacnttgtccctgagatttaacccctccactg ctgggggtgagctgtactcttctgactgc > 36690_at HG-U95Av2 gactattttcaagcaacctggtccacccaggattagtgaccaggttttcaggaaaggatt tgcttctctctagaaaatgtctgaaaggattttattttnnnnnnnnnnnnnn nnngaaaa -89- 98677.doc 200533758 taccctcctcaaataacttgcttaactacatatagattcaagtgtgtcaatattctattt tgtatattaaatgctatataatggggacaaatctatattatactgtgtatggcattatta agaagctttttcattattttttatcacagtaattttaaaatgtgtaaaaattaaaaccag tgactcctgtttaaaaataaaagntgtagttttttatteatgetgaataataatctgtag ttaaaaaaaaagtgtnnnnnnnnnnnnnnnntgaaatgtcagactgtaaaaccttgtgtg gaaatgtttaacttttattttttcatttaaatttgctgttctggtattacc > 36691_at HG-U95Av2 cttcagcgccactggctggaaggtgggctgggtcctgggtccagatcacatcatgaagca cctgcggaccgtgcaccagaactccgtcttccactgccccacgcagagccaggctgcagt agccgagagctttgaacgggagcagctgctcttccgccaacccagcagctactttgtgca gttcccgcaggccatgcagcgctgccgtgaccacatgatacgtagcctacagtcagtggg cctgaagcccatcatccctcagggcagctactteeteatcacagacatctcagacttcaa gaggaagatgcctgacttgcctggagctgtggatgagccctatgacagacgcttcg > 3 67 00__at HG-U95Av2 tacaaactgtgacctcagcttcagagtgtcagggcctcacttgtatagaatgtaatgttc tcctcaaacatttatgttaactctataaacaaatatcgttaagttadacdidgttttcaaa aacaaaacaatttttaaagtaccttaaaattgaggatgttactcagtgttaacacatggg

aacaccaaaatattcaataagcctggtcaattctatagtta >36711_at HG-U95Av2 ttgcacggatctaagttattctccccagccagagcccgngctnnctgctcccngggaaaa gntggcgtantggncctgagetgggntttatattttatatctgcaaataaatnacatttt atcntanatttagggaaagccngagagnaacaacaaaaaatgtttaagccnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntattgcccggctcct agaatttatttatttcctgacttacagcaagcgagttatcgtcttctgtattttg >36767_at HG-U95Av2 cagaggtagtctcactgcttgaactangctgagcaatctgaccctatgggtctaggacac agttcctgggaacatcacattcctctgcccttcctgcaggcaggaacaaacagggctgcc ttctggccttgtaagacccttattgctgtcctggaggggctggggacttgtgtctgcggg gatcagagcgcacagggagtgcacatatccaggcaccaggactagggctggagtgagggg ggggtatttcaattaccttctattggtctcccttctctacactcttgtaataaaatgtct atttttaatgtttgtacacaacaatccttctattctagcctgcattgagcttgcatgctt gcataagagcttaagaaccattgatttaatgtaatagggaaaattctaacccaggtatcc aaaaatgtgtaagaacaactacctgagctaaa >3 67 90_at HG-U95Av2 gagaagttccattcaaagtgccaatgatagagtcaacanggaaggttaatgttggaaaca caatcaggtgtggattggtgctactttgaacaaaaggtccccctgtggtcttttgttcaa cattgtacaat >3 67 91__g_at HG-U95Av2 ctgagtttgcggagaggtcagtaactaaattggagaaaagcattgatgacttagaagaga aagtggctcatgccaaagaagaaaaccttagtatgcatcagatgctggatcagactttac tggagttaaacaacatgtgaaaacctccttagctgcgaccacattctttcattttgtttt gttttgttttgttttnnnnntaaacacctgcttaccccttaaatgcaatttatttacttt taccactgtcacagaaacatccacaagataccagctaggtcagggggtggggaaaacaca tacaaaaagncaagcccatgtcagggcgatcctggttcaaatgtgccatttcccgggttg atgctgccacactttgtagagagtttagcaacacagtgtgctta >36792_at HG-U95Av2 gaagaagttccattcctttctgattggcacacgtgcagctcatgacaatctgtaggataa caatcagtgtggatttccactcttttcagtccttcatgttaaagatttagacaccacata caactggt 90- 98677.doc 200533758 >36825_at HG-U95Av2 cttggtttcactagtagtaaacattattattttttttatatttgcaaaggaaacatatct aatccttcctatangaangaacagtattgctgtaattccttttcttttcttcctcatttc ctctgccccttaaaagattgaagaaagagaaacttgtcaactcatatccacgttatctag caaagtacataagaatctatcactaagtaatgtatccttcagaatgtgttggtttaccag tgacaccccatattcatcacaaaattaaagcaagaagtccatagtaatttatttgctaat agtggatttttaatgctcagagtttctgaggtcaaattttatcttttcacttacaagctc tatgatcttaaataatttacttaatgtattttggtgtattttcctcaaattaatattggt gttcaagactatatctaattcctctgatcactnnnnnnnnnnnnnnnntattaaatgtaa ggcacttttctatgaattttaaatataaaaataaatattgttctgattattactgaaaan annnnagccatttcaatgtcttgggaaacaa >36852_at HG-U95Av2 ccacggctatccttatagtgatctggactttgagtgagaagatgtgatttggaccatggc acttaaaaactctat >36879_at HG-U95AV2 cgagccctgtgctcgggaagtcccgcagaacgccggcagctgctgcctcgcgcccgggag caggaggagctgctggcgcccgcagatggcaccgtggagctggtccgggcgctgccgctgaacaccaaaatattcaataagcctggtcaattctatagtta > 36711_at HG-U95Av2 ttgcacggatctaagttattctccccagccagagcccgngctnnctgctcccngggaaaa gntggcgtantggncctgagetgggntttatattttatatctgcaaataaatnacatttt atcntanatttagggaaagccngagagnaacaacaaaaaatgtttaagccnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntattgcccggctcct agaatttatttatttcctgacttacagcaagcgagttatcgtcttctgtattttg > 36767_at HG-U95Av2 cagaggtagtctcactgcttgaactangctgagcaatctgaccctatgggtctaggacac agttcctgggaacatcacattcctctgcccttcctgcaggcaggaacaaacagggctgcc ttctggccttgtaagacccttattgctgtcctggaggggctggggacttgtgtctgcggg gatcagagcgcacagggagtgcacatatccaggcaccaggactagggctggagtgagggg ggggtatttcaattaccttctattggtctcccttctctacactcttgtaataaaatgtct atttttaatgtttgtacacaacaatccttctattctagcctgcattgagcttgcatgctt gc ataagagcttaagaaccattgatttaatgtaatagggaaaattctaacccaggtatcc aaaaatgtgtaagaacaactacctgagctaaa > 3 67 90_at HG-U95Av2 gagaagttccattcaaagtgccaatgatagagtcaacanggaaggttaatgttggaaaca caatcaggtgtggattggtgctactttgaacaaaaggtccccctgtggtcttttgttcaa cattgtacaat > 3 67 91__g_at HG-U95Av2 ctgagtttgcggagaggtcagtaactaaattggagaaaagcattgatgacttagaagaga aagtggctcatgccaaagaagaaaaccttagtatgcatcagatgctggatcagactttac tggagttaaacaacatgtgaaaacctccttagctgcgaccacattctttcattttgtttt gttttgttttgttttnnnnntaaacacctgcttaccccttaaatgcaatttatttacttt taccactgtcacagaaacatccacaagataccagctaggtcagggggtggggaaaacaca tacaaaaagncaagcccatgtcagggcgatcctggttcaaatgtgccatttcccgggttg atgctgccacactttgtagagagtttagcaacacagtgtgctta > 36792_at HG-U95Av2 gaagaagttccattcctttctgattggcacacgtgcagctcatgacaatctgtaggataa caatcagtgtggatttccactcttttcagtccttcatgttaaagatttagacaccacata caactggt 90- 98677.doc 200533758 > 36825_at HG-U95Av2 cttggtttcactagtagtaaacattattattttttttatatttgcaaaggaaacatatct aatccttcctatangaangaacagtattgctgtaattccttttctttt cttcctcatttc ctctgccccttaaaagattgaagaaagagaaacttgtcaactcatatccacgttatctag caaagtacataagaatctatcactaagtaatgtatccttcagaatgtgttggtttaccag tgacaccccatattcatcacaaaattaaagcaagaagtccatagtaatttatttgctaat agtggatttttaatgctcagagtttctgaggtcaaattttatcttttcacttacaagctc tatgatcttaaataatttacttaatgtattttggtgtattttcctcaaattaatattggt gttcaagactatatctaattcctctgatcactnnnnnnnnnnnnnnnntattaaatgtaa ggcacttttctatgaattttaaatataaaaataaatattgttctgattattactgaaaan annnnagccatttcaatgtcttgggaaacaa > 36852_at HG-U95Av2 ccacggctatccttatagtgatctggactttgagtgagaagatgtgatttggaccatggc acttaaaaactctat > 36879_at HG-U95AV2 cgagccctgtgctcgggaagtcccgcagaacgccggcagctgctgcctcgcgcccgggag caggaggagctgctggcgcccgcagatggcaccgtggagctggtccgggcgctgccgctg

gcgctggtgctgcacgagctcggggccgggcgcanccgcgctgggganccgctccgcctg ggggtgggcgcanagctgctggtcgacgtgggtcagaggctgcgccgtgggaccccctgg ctccgcgtgcaccgggacggccccgcgctcagcggcccgcagagccgcgccctgcaggag gcgctngtactctccgaccgcgcgccattcgccgccccctcgcccttcgcagagctcgtt ctgccgccgcagcaataaagctcctttgccgcgaaaa >36929_at HG-U95Av2 gtgcccggatccagagtgtgaagacagaggcagaggagctgtttggggagaccatggaga tgatggacaggatgaaagacatggagttggagctgctgcggggcanccnaggccatcatg ctgcgctcagcggacctgacaggactggagaagcgtgtggagcannnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngccng ttnccnnnnnnatctgccgcctttgcttttggttgggggcagattgggttggaatgcttt ccatctccaggagactttcatgnagcctaaagtacagcctggaccacccctggtgtgtag ctagtaagattaccctgagetgcagctgagcctgagecaatgggacagttacacttgaca gacaaagatggtggagattggcatgccattgaaactaagagctctcaagtcaaggaagct gggctgggcagtatcccccgcctttagttctccactggggag >36965_at HG-U95Av2 aatgcttgccgctttagaggtggatggtgctcataaaaggccccagtcgggggtatttaa aaaggactgaacagaaatccttagctagtagaatggnnnnnnnnnnnnnnnnnnnnnnnt gtattgtgtactggctataagatgtagacacctttcagtaagccaatcatttgtaaccat tctagcagtgtcatattaggttaataaggctgctgtgttttaaagggcatttttatttgg gttttggtgaaattctttaatttgttgattatattcacataaaatcagcattcattgaca catagctctaatgacatatgtatgaaaaaccatacactggatgacctagtcgattatt >37015一at HG-U95Av2 gtgaaaatctctcagaagaactcataaangaaaatacaagagtggagagaagctcttcaa tagctaangcatctccttacagtcactaatatagtagattttnaaagacaaaatttttct tttcttgantttttttaaacataagctaaatcatattagtattaatactacccatagaaa acttgacatgtagcttcttctgaaagaattatttgccttctgaaatgtgacccccaagtc ctatcctaaataaaaaaagacaaattcggatgtatgatctctctagctttgtcatagtta tgtgattttcctttgtagctacttttgcaggataataattttatagaaaaggaacagttg catttagcttctttcccttagtgactcttgaagtacttaacatacacgttaactgcagag taaattgctctgttcccagtagttataaagtccttg >37〇27_at HG-U95Av2 gttgcagacggaggtcaggtcttccnnnnnnnnnnnnnnnnnnnnnnnnnnnnagcaaac gcccacagatggcccagaggtggtggtagtcagggtgtgtgggtgtttttagggttcttt agtgttgtttcttnnnnnnnnnnnnnnnnnnnnnnnnnngtttggtgctgacggtgagag gaaattagaatctgtttgcaaattgtccaacccaccccctcaacatgaggggcttccatt ttctgtgttttgtaagggaactgtttccttcatgccgccatgttcctgatattagttctg atttctttttaacaaatgttannnnnnnnnnnnnnnnnnnnnnnnnnntaatggccaatt -91 - 9S6^.doc 200533758 aactgagaatgtaagaaaattgatgctgtacaaggcaaataaagctgtttattaaccttn aaaaaaaaaaaaaaaaaaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnan ncngccatgttcctgatattagttctgat >37168_at HG-U95Av2 cagttgcteatttttatgggattgcttagetgggctgtaaagatgaaggcatcaaataaa ctcaaagtatttttaaatttttttgataatagagaaacttcgctaaccaactgttctttc ttgagtgtatagccccatcttgtggtaacttgctgcttctgcacttcatatccatatttc ctattgttcactttattctgtagagcagcctgccaagaattttatttctgctgttttttt tgctgctaaagaaaggaactaagtcaggatgttaacagaaaagtccacataaccctagaa ttcttagtcaaggaataattcaagtcagcctagagaccatgttgacttteeteatgtgtt tccttatgactcagtaagttggcaaggtcctgactttagtctta >37185一at HG-U95Av2 ctcaccctaaaactaagcgtgctgcttctgcaaaagatttttgtagatgagctgtgtgcc tcagaattgctatttcaaattgccaaaantttannnnnnnnnnnnnnnnnnnnctgctct tctgaacaacttctgctacccactaaataaaaacacagaaataattagacaattgtctat tataacatgacaaccctattaatcatttggtcttctaaaatgggatcatgcccatttaga ttttccttactatcagtttatttttataacattaacttttactttgttatttattattttgcgctggtgctgcacgagctcggggccgggcgcanccgcgctgggganccgctccgcctg ggggtgggcgcanagctgctggtcgacgtgggtcagaggctgcgccgtgggaccccctgg ctccgcgtgcaccgggacggccccgcgctcagcggcccgcagagccgcgccctgcaggag gcgctngtactctccgaccgcgcgccattcgccgccccctcgcccttcgcagagctcgtt ctgccgccgcagcaataaagctcctttgccgcgaaaa > 36929_at HG-U95Av2 gtgcccggatccagagtgtgaagacagaggcagaggagctgtttggggagaccatggaga tgatggacaggatgaaagacatggagttggagctgctgcggggcanccnaggccatcatg ctgcgctcagcggacctgacaggactggagaagcgtgtggagcannnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngccng ttnccnnnnnnatctgccgcctttgcttttggttgggggcagattgggttggaatgcttt ccatctccaggagactttcatgnagcctaaagtacagcctggaccacccctggtgtgtag ctagtaagattaccctgagetgcagctgagcctgagecaatgggacagttacacttgaca gacaaagatggtggagattggcatgccattgaaactaagagctctcaagtcaaggaagct gggctgggcagtatcccccgcctttagttctccactggggag > 36965_at HG-U95Av2 aatgcttgccgctttagaggtggatggtgctcataaaaggccccagtcgggggtatttaa aaaggactgaacagaaatccttagctagtagaatggnnnnnnnnnnnnnnnnnnnnnnnt gtattgtgtactggctata agatgtagacacctttcagtaagccaatcatttgtaaccat tctagcagtgtcatattaggttaataaggctgctgtgttttaaagggcatttttatttgg gttttggtgaaattctttaatttgttgattatattcacataaaatcagcattcattgaca catagctctaatgacatatgtatgaaaaaccatacactggatgacctagtcgattatt > 37015 a at HG-U95Av2 gtgaaaatctctcagaagaactcataaangaaaatacaagagtggagagaagctcttcaa tagctaangcatctccttacagtcactaatatagtagattttnaaagacaaaatttttct tttcttgantttttttaaacataagctaaatcatattagtattaatactacccatagaaa acttgacatgtagcttcttctgaaagaattatttgccttctgaaatgtgacccccaagtc ctatcctaaataaaaaaagacaaattcggatgtatgatctctctagctttgtcatagtta tgtgattttcctttgtagctacttttgcaggataataattttatagaaaaggaacagttg catttagcttctttcccttagtgactcttgaagtacttaacatacacgttaactgcagag taaattgctctgttcccagtagttataaagtccttg > 37〇27_at HG-U95Av2 gttgcagacggaggtcaggtcttccnnnnnnnnnnnnnnnnnnnnnnnnnnnnagcaaac gcccacagatggcccagaggtggtggtagtcagggtgtgtgggtgtttttagggttcttt agtgttgtttcttnnnnnnnnnnnnnnnnnnnnnnnnnngtttggtgctgacggtgagag gaaattagaatctgtttgcaaattgtccaacccaccccctcaacatgaggggcttccatt ttctgtgttttgtaaggga actgtttccttcatgccgccatgttcctgatattagttctg atttctttttaacaaatgttannnnnnnnnnnnnnnnnnnnnnnnnnntaatggccaatt -91 - 9S6 ^ .doc 200533758 aactgagaatgtaagaaaattgatgctgtacaaggcaaataaagctgtttattaaccttn aaaaaaaaaaaaaaaaaaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnan ncngccatgttcctgatattagttctgat > 37168_at HG-U95Av2 cagttgcteatttttatgggattgcttagetgggctgtaaagatgaaggcatcaaataaa ctcaaagtatttttaaatttttttgataatagagaaacttcgctaaccaactgttctttc ttgagtgtatagccccatcttgtggtaacttgctgcttctgcacttcatatccatatttc ctattgttcactttattctgtagagcagcctgccaagaattttatttctgctgttttttt tgctgctaaagaaaggaactaagtcaggatgttaacagaaaagtccacataaccctagaa ttcttagtcaaggaataattcaagtcagcctagagaccatgttgacttteeteatgtgtt tccttatgactcagtaagttggcaaggtcctgactttagtctta > 37185 a at HG-U95Av2 ctcaccctaaaactaagcgtgctgcttctgcaaaagatttttgtagatgagctgtgtgcc tcagaattgctatttcaaattgccaaaantttannnnnnnnnnnnnnnnnnnnctgctct tctgaacaacttctgctacccactaaataaaaacacagaaataattagacaattgtctat tataacatgacaaccctattaatcatttggtcttctaaaatgggatcatgcccatttaga ttttccttactatcagt ttatttttataacattaacttttactttgttatttattatttt

atataatggtgagtttttaaattattgctcactgcctatttaatgtagctaataaagtta tagaagcagatgatctgttaatttcctatctaataaatgcctttaattgttctcataatg aagaataagtaggtatccctccatgcccttct >37187—at HG-U95AV2 cgcctaatgtgtttgagcatcacttaggagaagtcntctatttatttatttattnattna tttgttngttttagaagnttctatgttaatattttatgtgtaaaataaggttatgantga atctacttgcacactcncccattatatttattgtttattttaggtcaaacccaagttagt tcaatcctgattcatatttaatttgaagatagaaggtttgcagatattctctagtcattt gttaatatttcttcgtgatgacatatcacatgtcagccactgtgatagaggctgaggaat ccaagaaaatggccagtnagatcaatgtgannnnnnnnnnnnnnnnnnnngtctattttg taactgtaaagatgaatgtcagttgttatttattgaaatgatttcacagtgtgtggtcaa catttctcatgttgaagctttaag >37218一at HG-U95AV2 gtgtaccagatttcagaacttatatttccacctcttccaatgtggcaccctttngcccag aaaaaagnccaggaatgtantcgagggaatggccatcagaatcactatcctcctcctgtt ccatttggttatccaaatcagggaagaaaaaataaaccatatcgcccaattccagtgaca tgggtacctcctcctggaatgcattgtgaccggaatcactggattaatcctcacatgtta gcacctcactaacttcgtttttgattgtgttggtgtcatgttgagaaaaaggtagaataa accttactacacattaaaagttaaaagttcttactaatagtagtgaagttagatgggcca aaccatcaaacttatttttatagaagttattgagaataatctttcttaaaaaatatatgc actttagatattgatatagtttgagaaattttattaaagttagtcaagtgccgaagtttt taatattggacttgagtatttatatattgtgcatcaactctgttggatacgagaacactg tagaagtggacgatttgttctagcacctttga >37221一at HG-U95AV2 tttatggtcccacttgtatatgaaaatgtggttagaatgttaattggataatgtatatat aagaagttaaagtatgtaaagtataacttcagccacatttttagaacactgtttaacatt tttgcaaaaccttcttgtaggaaaagagagctctctacatgaagatgacttgttttatat ttcagattttattttaaaagccatgtctgttaaacaagaaaaaacacaaaagaactccag attcctggttcatcattctgtattcttactcactttttcaagttatctattttgttgcat aaactaattgtt a annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna gaactttgacca aggctataaannnnacnnacattattttcagtattgttggttatatttaaattttcctta caataaagcacacttttataatnaaaannngaattattgtttttcatacttttttgcttg tttcttaaagttttctgacgtgc >37241_at HG-U95AV2 catgacatctggaacacagaaagccctcaatacattgaagctcttaggattttcacgatg ttcctgtctgctcaatgcatgctttctttattgttctgacagttgtgtggtaacaagcta atatgcttccagttgacttccagtctaccctggtgttagaaaccgtttcatctcttattg taaatttgagtgcttgttgttttttatatttgtgatgannnnnnnnnnnnnnnttgacaa 92- 98677.doc 200533758 ttgttagaggtttgacttttaaataattacttattttttctgattgtggttcagtttaac tgaagaatatcctgagattgtaagaaaagcattttttaaaaggtatcacttgtgatcatt tatct >372 55_at HG-U95AV2 gcttggacagccagtgccctcgtggnttcgggaagannnnnnnnnnnnnnnnnnnnnnnn ntgtcccagcctcccataccagcaaaatgccccctgcttccctaagggtcaggtccagag cagggcccacaagggggattagagtggcctggnccctccccctctacctcagtagccccc aggcctgagatggctgagaagggaagggtatccttttcccacagttctgggacaaataaa ggggcttcctttggtaccccacataatagtgctaggtacctttgacccatcatcttggga ggtggggaggaatgagagggtccaggcagggtgtaggggaatgtattagtccaatgagat ttccctcttcatccgcagcagtgtatctattctatacctggctatgggagagaccccttg catgggagggacccct t nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc c c ggcctccctaatgtcattcacattgaatggggatgaggtcggacagnngctcatagagcc gagtatgagccctagctgtgggctag >372 8 6_at HG-U95Av2 caccttttttgctgtgaaactgaaatagtgaacttttctacgtattgacagcagattttt cgatgaaatcttcagagctttgcctatggggcacagtaggcctagtaacctggcatgtttatataatggtgagtttttaaattattgctcactgcctatttaatgtagctaataaagtta tagaagcagatgatctgttaatttcctatctaataaatgcctttaattgttctcataatg aagaataagtaggtatccctccatgcccttct > 37187-at HG-U95AV2 cgcctaatgtgtttgagcatcacttaggagaagtcntctatttatttatttattnattna tttgttngttttagaagnttctatgttaatattttatgtgtaaaataaggttatgantga atctacttgcacactcncccattatatttattgtttattttaggtcaaacccaagttagt tcaatcctgattcatatttaatttgaagatagaaggtttgcagatattctctagtcattt gttaatatttcttcgtgatgacatatcacatgtcagccactgtgatagaggctgaggaat ccaagaaaatggccagtnagatcaatgtgannnnnnnnnnnnnnnnnnnngtctattttg taactgtaaagatgaatgtcagttgttatttattgaaatgatttcacagtgtgtggtcaa catttctcatgttgaagctttaag > 37218 a at HG-U95AV2 gtgtaccagatttcagaacttatatttccacctcttccaatgtggcaccctttngcccag aaaaaagnccaggaatgtantcgagggaatggccatcagaatcactatcctcctcctgtt ccatttggttatccaaatcagggaagaaaaaataaaccatatcgcccaattccagtgaca tgggtacctcctcctggaatgcattgtgaccggaatcactggattaatcctcacatgtta gcacctcactaacttcgtttttgattgtgttggtgtcatgttgagaaaaaggtagaataa accttactacacattaaaagttaaaagttcttactaat agtagtgaagttagatgggcca aaccatcaaacttatttttatagaagttattgagaataatctttcttaaaaaatatatgc actttagatattgatatagtttgagaaattttattaaagttagtcaagtgccgaagtttt taatattggacttgagtatttatatattgtgcatcaactctgttggatacgagaacactg tagaagtggacgatttgttctagcacctttga > 37221 a at HG-U95AV2 tttatggtcccacttgtatatgaaaatgtggttagaatgttaattggataatgtatatat aagaagttaaagtatgtaaagtataacttcagccacatttttagaacactgtttaacatt tttgcaaaaccttcttgtaggaaaagagagctctctacatgaagatgacttgttttatat ttcagattttattttaaaagccatgtctgttaaacaagaaaaaacacaaaagaactccag attcctggttcatcattctgtattcttactcactttttcaagttatctattttgttgcat aaactaattgtt a annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna gaactttgacca aggctataaannnnacnnacattattttcagtattgttggttatatttaaattttcctta caataaagcacacttttataatnaaaannngaattattgtttttcatacttttttgcttg tttcttaaagttttctgacgtgc > 37241_at HG-U95AV2 catgacatctggaacacagaaagccctcaatacattgaagctcttaggattttcacgatg ttcctgtctgctcaatgcatgctttctttattgttctgacagttgtgtggtaacaagcta atatgcttccagttgacttccagtctaccctggtgttagaaaccgtttcatctcttattg taaatttgagtgctt gttgttttttatatttgtgatgannnnnnnnnnnnnnnttgacaa 92- 98677.doc 200533758 ttgttagaggtttgacttttaaataattacttattttttctgattgtggttcagtttaac tgaagaatatcctgagattgtaagaaaagcattttttaaaaggtatcacttgtgatcatt tatct > 372 55_at HG-U95AV2 gcttggacagccagtgccctcgtggnttcgggaagannnnnnnnnnnnnnnnnnnnnnnn ntgtcccagcctcccataccagcaaaatgccccctgcttccctaagggtcaggtccagag cagggcccacaagggggattagagtggcctggnccctccccctctacctcagtagccccc aggcctgagatggctgagaagggaagggtatccttttcccacagttctgggacaaataaa ggggcttcctttggtaccccacataatagtgctaggtacctttgacccatcatcttggga ggtggggaggaatgagagggtccaggcagggtgtaggggaatgtattagtccaatgagat ttccctcttcatccgcagcagtgtatctattctatacctggctatgggagagaccccttg catgggagggacccct t nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc c c ggcctccctaatgtcattcacattgaatggggatgaggtcggacagnngctcatagagcc gagtatgagccctagctgtgggctag > 372 8 6_at HG-U95Av2 caccttttttgctgtgaaactgaaatagtgaacttttctacgtattgacagcagattttt cgatgaaatcttcagagctttgcctatggggcacagtaggcctagtaacctggcatgttt

gatatatgtaggtaaagcataatttaaagtaatcccaggtaaagatggccctaaatactt tcatgtctctatattcatttttcacagatccacctgtctcttgaaaatataaaaagacaa aacaggtttgccttggcatcagagagcacaaagattaaaagttactttaaatttgccaat attttgggagaacaataaaactacattttttcctcttccatactggtagatgcgaaattt atctgtgcatgaaagggtcacttctgtaatagtgcaacagatttggtattaaaaattaaa tgtggttttaaaagttcctctctcttttgtaatttatgttcccaattgagtgtgaatgtc caagtaatggtgtatgtaatggtacaggcaaatgtgactggatttc >372 87_at HG-U95Av2 tgtaaatggttctcggagcttctttgggttaaagggtctaatgccaggaacagcatacaa agttcgagttggtgctgtgggggactctggttttgtgagttcagaggatgtgtttgagac aggcccagcgatggcaagccggc >372 88__g_at HG-U95Av2 ctcagggctggttcattggtctgatgtgtgctgttgctctccttatcttaattttgctga ttgtttgcttcatcagaagaaacaagggtggtaaatatccagttaaagaaaannnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnagaagaccacaagcctttgaaaaaaggaagtcgaactccttcagacaggactg tgaaaaaagaagatagtgacgacagcctagttgactatggagaaggggttaatggccagt tcaatgaggatggctcctttattggacaatacagtggtaagaaagagaaagagccggctg aaggaaacgaa >37352_at HG-U95Av2 gatgccaagacttggcctgcagaatgtcaggaatgtgaattaaaagctgctgtttccaga cgctttttattctgagcaccttcactaccttgtatccagttcatctgggaactccttttt gcattttagaaaatggaaagaggcaggaaattatgataaactcatgtttaacagaaagag tttcactgactaaatgtatgtaattatattttgttgttgtagaagaaataaatagcaaat ttgtggtattcttttttttaaacctgctctcartcctattaacactaagatcttagattt ttatagtgataaatgggttgacatcattgtcatttgtaattgtaaagcctcaaaagacaa ctgttcctactatgtaattatagacag >37353_g_at HG-U95Av2 aagcaagcatggtgagaaggctcctatgacttctagaagtacatctacttggagaatacc cagcaggaagagacgtttcagcagtagtgacttttcagacctgagtaatggagaagagct tcaggaaacctgcagctcatccctaagaagagggtc >37354一at HG-U95Av2 ttctactttggaaaaacacagtgggaaaagaagaaaaaagagaaggcatagatctaaagt aaatggtctccaaagagggagaaagaaagacagacctagaaaacatttaactctgaataa caaagtccaaaagaaaagatggcaacaaagaggaagaaaagccaacactagacctttgaa aagaagaagaaaaagaggtccaagnatncccnaagntgaaaatattaattttaaacaatc tgaacttcctgtnacctgtggtgaggtganggncactctatntaaggagcgattcaaaca 93- 98677.doc 200533758 aggaacctcaaagaagtgtntacagngtgaggataaaaagtggttcactcccagggaatt tgaaattgaaggagaccgcggagcatccaagaactggaagctaagtatacgctgcggtgg atataccctgaaagtcctgatggagaacaaatttctgccagaaccaccaagcacaagaaa aaaggtgatnnnnnnnnnnnnnnnnnnnaatgtctcgtctattatgttgttgattttcta tctctgtggacttac >37377_i_at HG-U95Av2 ctctgtgcagtcactggaggttgaagccaagtggggtgctgggaggagggagagggaggt cactggaaaggggagagcctgctggcacccaccgtggaggaggaaggcaagagggggtgg aggggtgtggcagtggttttggcaaacgctaaagagcccttgcctc >37383_f_at HG-U95Av2 cctttgtgacttcaagagcctctggcatctctttctgcaaaggcanctgaatgtgtctgc gtncctgttagcataatgtgaggaggtggagagacagcccacccnngtgtccacngtgac ccctgtncccannctgacctgtgttncctccccnntcatctttcntgttccagagangtg ggnctggatgtctccatctctgtctcaa >37388_at HG-U95Av2 ttgacaaatgtatatgcctgagaactttgaatgatgctgaaagctagaagcaaaccaggtgatatatgtaggtaaagcataatttaaagtaatcccaggtaaagatggccctaaatactt tcatgtctctatattcatttttcacagatccacctgtctcttgaaaatataaaaagacaa aacaggtttgccttggcatcagagagcacaaagattaaaagttactttaaatttgccaat attttgggagaacaataaaactacattttttcctcttccatactggtagatgcgaaattt atctgtgcatgaaagggtcacttctgtaatagtgcaacagatttggtattaaaaattaaa tgtggttttaaaagttcctctctcttttgtaatttatgttcccaattgagtgtgaatgtc caagtaatggtgtatgtaatggtacaggcaaatgtgactggatttc > 372 87_at HG-U95Av2 tgtaaatggttctcggagcttctttgggttaaagggtctaatgccaggaacagcatacaa agttcgagttggtgctgtgggggactctggttttgtgagttcagaggatgtgtttgagac aggcccagcgatggcaagccggc > 372 88__g_at HG-U95Av2 ctcagggctggttcattggtctgatgtgtgctgttgctctccttatcttaattttgctga ttgtttgcttcatcagaagaaacaagggtggtaaatatccagttaaagaaaannnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnagaagaccacaagcctttgaaaaaaggaagtcgaactccttcagacaggactg tgaaaaaagaagatagtgacgacagcctagttgactatggagaaggggttaatggccagt tcaatgaggatggctcctttattggacaatacagtggtaagaaagagaaagagccggctg aaggaaacgaa > 37352_at HG-U95Av2 gatgccaagacttggcctgcagaatgtcaggaatgtgaattaaaagctgctgtttccaga cgctttttattctgagcaccttcactaccttgtatccagttcatctgggaactccttttt gcattttagaaaatggaaagaggcaggaaattatgataaactcatgtttaacagaaagag tttcactgactaaatgtatgtaattatattttgttgttgtagaagaaataaatagcaaat ttgtggtattcttttttttaaacctgctctcartcctattaacactaagatcttagattt ttatagtgataaatgggttgacatcattgtcatttgtaattgtaaagcctcaaaagacaa ctgttcctactatgtaattatagacag > 37353_g_at HG-U95Av2 aagcaagcatggtgagaaggctcctatgacttctagaagtacatctacttggagaatacc cagcaggaagagacgtttcagcagtagtgacttttcagacctgagtaatggagaagagct tcaggaaacctgcagctcatccctaagaagagggtc > 37354 a at HG-U95Av2 ttctactttggaaaaacacagtgggaaaagaagaaaaaagagaaggcatagatctaaagt aaatggtctccaaagagggagaaagaaagacagacctagaaaacatttaactctgaataa caaagtccaaaagaaaagatggcaacaaagaggaagaaaagccaacactagacctttgaa aagaagaagaaaaagaggtccaagnatncccnaagntgaaaatattaattttaaacaatc tgaacttcctgtnacctgtggtgaggtganggncactctatntaaggagcgattcaaaca 93- 98677.doc 200533758 aggaacctcaaagaagtgtntacagngtgaggataaaaagtggttcactcccaggga att tgaaattgaaggagaccgcggagcatccaagaactggaagctaagtatacgctgcggtgg atataccctgaaagtcctgatggagaacaaatttctgccagaaccaccaagcacaagaaa aaaggtgatnnnnnnnnnnnnnnnnnnnaatgtctcgtctattatgttgttgattttcta tctctgtggacttac > 37377_i_at HG-U95Av2 ctctgtgcagtcactggaggttgaagccaagtggggtgctgggaggagggagagggaggt cactggaaaggggagagcctgctggcacccaccgtggaggaggaaggcaagagggggtgg aggggtgtggcagtggttttggcaaacgctaaagagcccttgcctc > 37383_f_at HG-U95Av2 cctttgtgacttcaagagcctctggcatctctttctgcaaaggcanctgaatgtgtctgc gtncctgttagcataatgtgaggaggtggagagacagcccacccnngtgtccacngtgac ccctgtncccannctgacctgtgttncctccccnntcatctttcntgttccagagangtg ggnctggatgtctccatctctgtctcaa > 37388_at HG-U95Av2 ttgacaaatgtatatgcctgagaactttgaatgatgctgaaagctagaagcaaaccaggt

actcttcagtcagggactggttgaagattttatggatgaggagttagcaaaatatctata tatgcatatcttctgactcccagggatacataagaaacacagggcctagaacagtatgaa taaacacacatatacacaaacatcacagaagatactaaaggtat >37393—at HG-U95AV2 tcccgatggccagtttgctttcctcattcccaacggggccttcgcncacagcggccntgt catccccgtctacaccagcaacagcggcacctccgtgggccccaacgcagtgtcaccttc cagcggcccctcgcttacggcggactccatgtggaggccgtggcggaactgaggggnnnt caggccnacccctcctcctaaactccccaacccacctctcttccctccggactctaaaca ggaacttgaatactgggagagaagaggacttttttgattaagtggttactttgtgttttt ttaatttctaagaagttactttttgtagagagagctgtattaagtgactgaccatgcact atatttgtatatattttatatgttcatattggattgcgcctttgtattataaaagctcag atgacatttcgttttttacacgagat >37402—at HG-U95Av2 aaaggtcacctgcaagaacgggcagggcaactgctacaagagcaactccagcatgcacat cacagactgccgcctgacaaacggctccanggtanccccaactgtgcataccggaccagc ccgaaggagagacacatcattgtggcctgtgaagggagcccatatgtgccagtccacttt gatgcttctgtggaggactctacctaaggtcagagcagcgagataccccacctccctcaa cctcatcctctccacagctgcctcttccctcttccttccctgctgtgaaagaagtaacta cagttagggctcctat >37417一at HG-U95Av2 ccgctcttcttgaatcatgctgggctgcccctgctcagcaccccgcctggtgtgggcctg gtctcagcagcggctgcggctgtggcagcctccatctccagcaagtctcctggcctctcc tcctcatcctcttcatcctcatcctcctcctcctccacttgcagcgagacggcagcacag acccctggaggtccaggggggcccgaggcagggtccaaacctgagtgagggccagccatg cctcccctcccattcctctggtccctgccttggtcccttgcctgggaagagggcgaggag gccagtggtggggacncagagggtcctcagagcaggagtgacaagggaggaaagaccaaa aaaacaaccaaccaaaaaaaaaaaaaaaaaaggaaagaaactaaccaacaaaagagaaaa ccaaaaataatcacaacagaaaccagctgccccaaaggaaccagaggtga >37419_g_at HG-U95Av2 gagaaacgcatcaacccctgcagtgcggcccccatgctgcccagcccagggaagccggcc agctacagcccccatatggtcacaccccaagggggcgcggggaccttaccgttgtcccaa gcttccagcagtctgagcacaacagttactaccttatcctcagctgtggggacgctccac cccagecggacagetggagggggtgggggcgggggcggggctgcgccccccctcaattcc atcccctctgtcactcccccacccccggccaccaccaacagcacaaaccccagccctcaa ggcagccactcggctatcggcttgtcaggcctga >37420_i_at HG-U95Av2 cgcagatcctccaaaggcacacgttgcccaccaccccatctctgaccatgaggccaccct 94- 98677.doc 200533758 gaggtgctgggccctgggcttctaccctgcggagatcacgctgacctggcagcgggatgg ggaggaacagacccaggacacagagcttgtggagaccaggcctgcaggggatggaacctt ccagaagtgggccgctgtggtggtgccttctggagaggaacagagatacacatgccatgt gcagcacgaggggctgcccnagccncnnatcctgagatgggagcagtctccccagcccac cannnnnnnnnnnnnnnntcgttgctggccttgttgtccttggagctgtggtcactggag ctgtggtcgctgctgtgatgtggaggaagaagagctcagatagaaacagagggagcnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngg t gtctctcacagctaataaag tgtgagacagcttccttgtgtgggactgagaagcaagatatcaatgtagcagaattgcac ttgtgcctcacgaacatacat >37421_f_at HG-U95Av2 ccgcagatacttggagaatgggaaggagacgctacagcncgcagatcctccaaaggcaca cgttgcccaccaccccatctctgaccatgaggccaccctgaggtgctgggccctgggctt ctaccctgcggagatcacgctgacctggcagcgggatggggaggaacagacccaggacac agagcttgtggagaccaggcctgcaggggatggaaccttccagaagtgggccgctgtggt ggtgccttctggagaggaacagagatacacatgccatgtgcagcacgaggggctgcccna gccncnnatcctgagatgggagcagtctccccagcccaccannnnnnnnnnnnnnnntcg ttgctggccttgttgtccttggagctgtggtcactggagctgtggtcgctgctgtgatgt ggaggaagaagagctcagatagaaacagagggagcnnnnnnnnnnnnnnnnnnnnnnnnnactcttcagtcagggactggttgaagattttatggatgaggagttagcaaaatatctata tatgcatatcttctgactcccagggatacataagaaacacagggcctagaacagtatgaa taaacacacatatacacaaacatcacagaagatactaaaggtat > 37393-at HG-U95AV2 tcccgatggccagtttgctttcctcattcccaacggggccttcgcncacagcggccntgt catccccgtctacaccagcaacagcggcacctccgtgggccccaacgcagtgtcaccttc cagcggcccctcgcttacggcggactccatgtggaggccgtggcggaactgaggggnnnt caggccnacccctcctcctaaactccccaacccacctctcttccctccggactctaaaca ggaacttgaatactgggagagaagaggacttttttgattaagtggttactttgtgttttt ttaatttctaagaagttactttttgtagagagagctgtattaagtgactgaccatgcact atatttgtatatattttatatgttcatattggattgcgcctttgtattataaaagctcag atgacatttcgttttttacacgagat > 37402-at HG-U95Av2 aaaggtcacctgcaagaacgggcagggcaactgctacaagagcaactccagcatgcacat cacagactgccgcctgacaaacggctccanggtanccccaactgtgcataccggaccagc ccgaaggagagacacatcattgtggcctgtgaagggagcccatatgtgccagtccacttt gatgcttctgtggaggactctacctaaggtcagagcagcgagataccccacctccctcaa cctcatcctctccacagctgcctcttccctcttccttccctgctgtgaaagaagtaacta cagttagggctcctat > 374 17 a at HG-U95Av2 ccgctcttcttgaatcatgctgggctgcccctgctcagcaccccgcctggtgtgggcctg gtctcagcagcggctgcggctgtggcagcctccatctccagcaagtctcctggcctctcc tcctcatcctcttcatcctcatcctcctcctcctccacttgcagcgagacggcagcacag acccctggaggtccaggggggcccgaggcagggtccaaacctgagtgagggccagccatg cctcccctcccattcctctggtccctgccttggtcccttgcctgggaagagggcgaggag gccagtggtggggacncagagggtcctcagagcaggagtgacaagggaggaaagaccaaa aaaacaaccaaccaaaaaaaaaaaaaaaaaaggaaagaaactaaccaacaaaagagaaaa ccaaaaataatcacaacagaaaccagctgccccaaaggaaccagaggtga > 37419_g_at HG-U95Av2 gagaaacgcatcaacccctgcagtgcggcccccatgctgcccagcccagggaagccggcc agctacagcccccatatggtcacaccccaagggggcgcggggaccttaccgttgtcccaa gcttccagcagtctgagcacaacagttactaccttatcctcagctgtggggacgctccac cccagecggacagetggagggggtgggggcgggggcggggctgcgccccccctcaattcc atcccctctgtcactcccccacccccggccaccaccaacagcacaaaccccagccctcaa ggcagccactcggctatcggcttgtcaggcctga > 37420_i_at HG-U95Av2 cgcagatcctccaaaggcacacgttgcccaccaccccatctctgaccatgaggccaccct 94- 98677.doc 200533758 gaggtgctgggccctgggcttctaccctg cggagatcacgctgacctggcagcgggatgg ggaggaacagacccaggacacagagcttgtggagaccaggcctgcaggggatggaacctt ccagaagtgggccgctgtggtggtgccttctggagaggaacagagatacacatgccatgt gcagcacgaggggctgcccnagccncnnatcctgagatgggagcagtctccccagcccac cannnnnnnnnnnnnnnntcgttgctggccttgttgtccttggagctgtggtcactggag ctgtggtcgctgctgtgatgtggaggaagaagagctcagatagaaacagagggagcnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngg t gtctctcacagctaataaag tgtgagacagcttccttgtgtgggactgagaagcaagatatcaatgtagcagaattgcac ttgtgcctcacgaacatacat > 37421_f_at HG-U95Av2 ccgcagatacttggagaatgggaaggagacgctacagcncgcagatcctccaaaggcaca cgttgcccaccaccccatctctgaccatgaggccaccctgaggtgctgggccctgggctt ctaccctgcggagatcacgctgacctggcagcgggatggggaggaacagacccaggacac agagcttgtggagaccaggcctgcaggggatggaaccttccagaagtgggccgctgtggt ggtgccttctggagaggaacagagatacacatgccatgtgcagcacgaggggctgcccna gccncnnatcctgagatgggagcagtctccccagcccaccannnnnnnnnnnnnnnntcg ttgctggccttgttgtccttggagctgtggtcactggagctgtggtcgctgctgtgatgt ggaggaagaagagctcagatagaaacagagggagcnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnggtgtctctcacagctaataaagtg >37423一at HG-U95AV2 ttcataaatgttctatacagtggacagccctccagaatggtacttcagtgcctagtgtag taactgaaatcttcaatgacacattaacatcacaatggcgaatggtgacttttctttcac gatttcattaatttgaaagcacacaggaaagttgctccattgataacgtgtatggagact tcggttttagtcaattccatatctcaatcttaatggtgattcttctntgttgaactgaag tttgtgagagtagttttcctttgctacttgaatagcaataaaagcgtgttaactttttga ttgatgaaagaagtacaaaaagcctttagccttgaggtgccttctgaaattaaccaaat >37452_at HG-U95AV2 tagagactcaactatccaagtggtggagaatggggagtcctccnagggccgattttccgt ccagatgttccggtttgctggaaactatgacctagtctacctgnactgtgaagtctatct ctgtgacaccnnnnnnnnnnnnnnnnnnnntacctgctctgggaccagattccgaagtgg gagtgtcatagatcaatcccgtgtcctgaacttgggtcccatcacacggaaaggtgtcca ggccacagtctcaagggcttttagcagcttgnnnnnnnnnnnnnnntggctgcctctgct tctctcggccaccttgaccctgacttttcagtgactgacagcggaaagccctgtgctcca tggctgccatctcacctcctgctgggcagggggcatgatgcgggccagtgctccagccac agaaaagaaagttcatgctttgttcagcctgccttct >37459_atHG-U95Av2 gagaccgggtgttcctccagatgccctc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnntccactcctcnnnttcnnnntanntattgtatcccatgtaanannnnnnnnannnna aanaaanaaannannnnnannntatagaagaaaatgacacaccaaaaaatccaaatgaaa aacataattgcttcaaaacacttacacagttggaaagttatatgtaagtgaaaatttgga ccattgtgtacaaataaaaactaagatgcatgtttaatactccananannngnnnngnaa nnncgaatgantgggatagagttatgtatcaagtactgacacttggttgtacccactgga atcatattagctgttttatgttatatgcttccacagtaacctgcttattcagatcagtca aaatatatcagtatgaaagatcatagctaatgaaaggcactcactcatattgtttacttt aaaatatttataaatangccttaaagaaatacaaatgatancaattananannnnannna nnnnnntaatttcctctgtatttgtgtagatactttg >37461__at HG-U95Av2 cgctcaaggccacaaccatgatgatncgaccagcagatttctaaacatcccagtccacct gaggaactgtctcgaactattttcaaagacttaagcccagtgcactgaaagtcacggctg cgcactgtgtcctcttccaccacagagggcgtgtgctcggtgctgacgggacccacatgc tccagattagagcctgtaaactttatcacttaaacttgcatcacttaacggaccaaagca agaccctaaacatccataattgtgattagacagaacacctatgcaaagatgaacccgagg ctgagaatcagactgacagtttacannnnnnnnnnnnnnnnnnaagaatgttatgtgcaa gtttatcagtaaataactggaaaacagaacacttatgttatacaatacagatcatcttgg aactgcattcttctgagcactgtttatacactgtgtaaatacccatatgtcctgaat 95- 98677.doc 200533758 >37484_at HG-U95Av2 tcttctgacatcagccaagtcaatgtttcgcttatcttgtggaaaccaacttttataaaa teatatttttccagcttaaatcttactataaggggagaacttcnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnatatccaaagatggg ctaccgggcagagtgccattatgggtcatcctgctgagtgcttttgccggattgttgctg ttaatgctgctnnnnnnnnnnnnnnnnnnnattggattcttcaaaagaccactgaaaaag aaaatggagaaatgaaatattttacgaaagaaaataataacaattattcaataatctann ntcannnnnnnnnnnnnnntgtgacaagaaatgtataattcatgacatagtcatgtaact atgtaatccatcagggattcattacttggaaaatgacaggtcatgcattatccaa >374 93_at HG-U95Av2 caaagcagtgtttgtcctaatttatatattgtttttctagttcattttgtgtttccaact tttcatgtaaaattttaattatttttgaatgtgtggatgtgagactgaggtgccttttgg tactgaaattctttttccatgtacctgaagtgttacttttgtgatataggaaatccttgt atatatactttattggtccctaggcttcctattttgttaccttgctttctctatggcatc caccattttgattgttctacttttatgatatgttttcataagtggttaagcaagtattct cgttacttttgctcttaaatccctattcattacagcaatgttggtggtcaaagaaaatga tasacaacttgaatgttcaatggtcctgaastacataacsacatttteigtacattgtaaa gtagaatcctctgttcataatgnnnnnnnnnnnnnnnnggtgtctctcacagctaataaagtg > 37423 a at HG-U95AV2 ttcataaatgttctatacagtggacagccctccagaatggtacttcagtgcctagtgtag taactgaaatcttcaatgacacattaacatcacaatggcgaatggtgacttttctttcac gatttcattaatttgaaagcacacaggaaagttgctccattgataacgtgtatggagact tcggttttagtcaattccatatctcaatcttaatggtgattcttctntgttgaactgaag tttgtgagagtagttttcctttgctacttgaatagcaataaaagcgtgttaactttttga ttgatgaaagaagtacaaaaagcctttagccttgaggtgccttctgaaattaaccaaat > 37452_at HG-U95AV2 tagagactcaactatccaagtggtggagaatggggagtcctccnagggccgattttccgt ccagatgttccggtttgctggaaactatgacctagtctacctgnactgtgaagtctatct ctgtgacaccnnnnnnnnnnnnnnnnnnnntacctgctctgggaccagattccgaagtgg gagtgtcatagatcaatcccgtgtcctgaacttgggtcccatcacacggaaaggtgtcca ggccacagtctcaagggcttttagcagcttgnnnnnnnnnnnnnnntggctgcctctgct tctctcggccaccttgaccctgacttttcagtgactgacagcggaaagccctgtgctcca tggctgccatctcacctcctgctgggcagggggcatgatgcgggccagtgctccagccac agaaaagaaagttcatgctttgttcagcctgccttct > 37459_atHG-U95Av2 gagaccgggtgttcctccagatgccctc nnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnn nnntccactcctcnnnttcnnnntanntattgtatcccatgtaanannnnnnnnannnna aanaaanaaannannnnnannntatagaagaaaatgacacaccaaaaaatccaaatgaaa aacataattgcttcaaaacacttacacagttggaaagttatatgtaagtgaaaatttgga ccattgtgtacaaataaaaactaagatgcatgtttaatactccananannngnnnngnaa nnncgaatgantgggatagagttatgtatcaagtactgacacttggttgtacccactgga atcatattagctgttttatgttatatgcttccacagtaacctgcttattcagatcagtca aaatatatcagtatgaaagatcatagctaatgaaaggcactcactcatattgtttacttt aaaatatttataaatangccttaaagaaatacaaatgatancaattananannnnannna nnnnnntaatttcctctgtatttgtgtagatactttg > 37461__at HG-U95Av2 cgctcaaggccacaaccatgatgatncgaccagcagatttctaaacatcccagtccacct gaggaactgtctcgaactattttcaaagacttaagcccagtgcactgaaagtcacggctg cgcactgtgtcctcttccaccacagagggcgtgtgctcggtgctgacgggacccacatgc tccagattagagcctgtaaactttatcacttaaacttgcatcacttaacggaccaaagca agaccctaaacatccataattgtgattagacagaacacctatgcaaagatgaacccgagg ctgagaatcagactgacagtttacannnnnnnnnnnnnnnnnnaagaatgttatgtgcaa gtttatcagtaaataactggaaaacagaacacttatgttatacaatacagatcatcttgg aactgcattcttctgagca ctgtttatacactgtgtaaatacccatatgtcctgaat 95- 98677.doc 200533758 > 37484_at HG-U95Av2 tcttctgacatcagccaagtcaatgtttcgcttatcttgtggaaaccaacttttataaaa teatatttttccagcttaaatcttactataaggggagaacttcnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnatatccaaagatggg ctaccgggcagagtgccattatgggtcatcctgctgagtgcttttgccggattgttgctg ttaatgctgctnnnnnnnnnnnnnnnnnnnattggattcttcaaaagaccactgaaaaag aaaatggagaaatgaaatattttacgaaagaaaataataacaattattcaataatctann ntcannnnnnnnnnnnnnntgtgacaagaaatgtataattcatgacatagtcatgtaact atgtaatccatcagggattcattacttggaaaatgacaggtcatgcattatccaa > 374 93_at HG-U95Av2 caaagcagtgtttgtcctaatttatatattgtttttctagttcattttgtgtttccaact tttcatgtaaaattttaattatttttgaatgtgtggatgtgagactgaggtgccttttgg tactgaaattctttttccatgtacctgaagtgttacttttgtgatataggaaatccttgt atatatactttattggtccctaggcttcctattttgttaccttgctttctctatggcatc caccattttgattgttctacttttatgatatgttttcataagtggttaagcaagtattct cgttacttttgctcttaaatccctattcattacagcaatgttggtggtcaaagaaaatga tasacaacttgaatgttcaatggtcctgaastacataacsa catttteigtacattgtaaa gtagaatcctctgttcataatg

>374 94__at HG-U95Av2 gcccccttgggaggtcaacaagcctggggaggtgtgttgagacccccaggcctagacagg caaggggatggagagggcttgccttccctcccgcctgaccttcctcagtcatttctgcaa agccaaggggcagcctcctgtcaaggtagctagannnnnnnnnnnnnnnnnnnnnnnnnn nnggcccccttgaccttcagcaaatcacttctctccctgnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnntttttcctgtcaggttaacttatttgtaggttctgcattat tagaactttctagatatactcattccatctccccctcatttttttaatcaggtttccttg cttttgccatttttcttccttcttttttcactgatttattatgagagtggggctgaggtc tgagctgagccttat >37514一s一at HG-U95AV2 ctgaacctgtgttcgggcgcctggcatcccccggctttccaggggagtatgccaatgacc aggagcggcgctggaccctgactgcaccccccggctaccgcctgcgcctctacttcaccc acttcgacctggagctctcccacctctgcgagtacgacttcgtcaagctgagctcggggg ccaaggtgctggccacgctgtgcgggcaggagagcacagacacggagcgggcccctggca aggacactttctactcgctgggctccagcctggacattaccttccgctccgactactcca acgagaagccgttcnnnnnnnnnnnnnnnnnnnnnncagccgaggacattgacgagtgcc aggtggccccgggagaggcgcccacctgcgaccaccactgccacaaccacctgggcggtt tctactgctcctgccgcgcagg >37534一at HG-U95Av2 cttttatatgctaaaggagcatctatcagattaagttagaacatttgctgtcagccacat attgagatgacactaggtgcaatagcagggatagattttgttggtgagtagtctcatgcc ttgagatctgtggtggtcttcnnnnnnnnnnnnnnnnngatcaaggatgtagtatctcat agttcccaggtgatatttttcttattagaaaaatattataactcatttgttgtttgacac ttatagattgaaatttcctaatttattct a aannnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnttgttgttgttttnggatggtgttacatattatatgttctagaaacatgtaatcc taaatttaccctcttgaatataatccctggatgatattttttatcataaatgcagaataa t c aa a t a c annnnnnnnnnnnnnnnnnnnnnnnnnnnnt t nnnnnnnnnnnnnnnnnnnn nnnnnnnngttgctgttgtgtgatcaaacatgtctctgtgtagttccagcaa >37565_at HG-U95Av2 agtccatgagttatatcctggctcagtnggagtgatatttatgtattatttttacttttc tctcagtgtcttatattaagattaacatgttgttaatagttgctttgttgattaatctct cttgttggtgttttaataaatgaaataggcttgcctttagatcgggtgctgatattgcct gtttcctagtaatgggctgatcaaatgatcagtggaattcttggtttgatgataacctta ttaattgaaattttttactgatgtggctttaaaagaggtttattttgtatatgtttagaa ctctctgattttgatgaattatatgggaatgagaaacagaagaagtggtatttgctggcg agttaaataggcaaggtacccagtgataacaccaaccaaaccactcctatcnnnnnnnnn nnnnnnnnnnngatgcctgttgttttactgtgtatattttatttttaatatattaacttt gtggattcatttaaggtctactcaaaagtaacactgtca 96- 98677.doc 200533758 >37608_g_at HG-U95Av2 ttccagtcagcagaggaagccttgaggggcttgtatggtcgtgtgaggaaaggggctgtg cttgtctgtgcctgggctgaggagggcgccgacgccctgggccctgatggcaaattgctc cactcggatgctttcccgccaccccgcgtggtggatacactgnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnncggcaagaagtgtggcctgcagggctttgatggcatcgtgtgagag caggtgccggctcctcacacaccatggagactaccattgcggctgcatcgccttctcccc tccatccagcctggcgtccaggttgccctgttcaggggacagat >37611一at HG-U95AV2 ggatcgttatctactgactatattttcccttattactgcttgcagtaattcaactggaaa ttaaaaaaaaaaaactagactccattgtgccttactaaatatgggaatgtctaacttaaa tagctttgagatttcagctatgctagaggcttttattagnnnnnnnnnnnnnnnnnnnnn nnangttactaatatatctgtaacactattacagtattgctatttatattcattcagata taagatttgtacatattatcatcctataaagaaacggtatgacttaattttagaaagaaa attatattctgtttattatgacaaatgaaagagaaaatatatatttttaatggaaagttt gtagcatttttctaataggtactgccatatttttctgtgtgg≫ 374 94__at HG-U95Av2 gcccccttgggaggtcaacaagcctggggaggtgtgttgagacccccaggcctagacagg caaggggatggagagggcttgccttccctcccgcctgaccttcctcagtcatttctgcaa agccaaggggcagcctcctgtcaaggtagctagannnnnnnnnnnnnnnnnnnnnnnnnn nnggcccccttgaccttcagcaaatcacttctctccctgnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnntttttcctgtcaggttaacttatttgtaggttctgcattat tagaactttctagatatactcattccatctccccctcatttttttaatcaggtttccttg cttttgccatttttcttccttcttttttcactgatttattatgagagtggggctgaggtc tgagctgagccttat > 37514 a a s at HG-U95AV2 ctgaacctgtgttcgggcgcctggcatcccccggctttccaggggagtatgccaatgacc aggagcggcgctggaccctgactgcaccccccggctaccgcctgcgcctctacttcaccc acttcgacctggagctctcccacctctgcgagtacgacttcgtcaagctgagctcggggg ccaaggtgctggccacgctgtgcgggcaggagagcacagacacggagcgggcccctggca aggacactttctactcgctgggctccagcctggacattaccttccgctccgactactcca acgagaagccgttcnnnnnnnnnnnnnnnnnnnnnncagccgaggacattgacgagtgcc aggtggccccgggagaggcgcccacctgcgaccaccactgccacaaccacctgggcggtt tctactgctcctgccgcgcagg > 37534 at HG-U95Av2 cttttatatgctaaaggagcatctatca a gattaagttagaacatttgctgtcagccacat attgagatgacactaggtgcaatagcagggatagattttgttggtgagtagtctcatgcc ttgagatctgtggtggtcttcnnnnnnnnnnnnnnnnngatcaaggatgtagtatctcat agttcccaggtgatatttttcttattagaaaaatattataactcatttgttgtttgacac ttatagattgaaatttcctaatttattct a aannnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnttgttgttgttttnggatggtgttacatattatatgttctagaaacatgtaatcc taaatttaccctcttgaatataatccctggatgatattttttatcataaatgcagaataa t c aa a t a c annnnnnnnnnnnnnnnnnnnnnnnnnnnnt t nnnnnnnnnnnnnnnnnnnn nnnnnnnngttgctgttgtgtgatcaaacatgtctctgtgtagttccagcaa > 37565_at HG-U95Av2 agtccatgagttatatcctggctcagtnggagtgatatttatgtattatttttacttttc tctcagtgtcttatattaagattaacatgttgttaatagttgctttgttgattaatctct cttgttggtgttttaataaatgaaataggcttgcctttagatcgggtgctgatattgcct gtttcctagtaatgggctgatcaaatgatcagtggaattcttggtttgatgataacctta ttaattgaaattttttactgatgtggctttaaaagaggtttattttgtatatgtttagaa ctctctgattttgatgaattatatgggaatgagaaacagaagaagtggtatttgctggcg agttaaataggcaaggtacccagtgataacaccaaccaaaccactcctatcnnnnnnnnn nnnnnnnnnnngatgcctgttgtttt actgtgtatattttatttttaatatattaacttt gtggattcatttaaggtctactcaaaagtaacactgtca 96- 98677.doc 200533758 > 37608_g_at HG-U95Av2 ttccagtcagcagaggaagccttgaggggcttgtatggtcgtgtgaggaaaggggctgtg cttgtctgtgcctgggctgaggagggcgccgacgccctgggccctgatggcaaattgctc cactcggatgctttcccgccaccccgcgtggtggatacactgnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnncggcaagaagtgtggcctgcagggctttgatggcatcgtgtgagag caggtgccggctcctcacacaccatggagactaccattgcggctgcatcgccttctcccc tccatccagcctggcgtccaggttgccctgttcaggggacagat > 37611 a at HG-U95AV2 ggatcgttatctactgactatattttcccttattactgcttgcagtaattcaactggaaa ttaaaaaaaaaaaactagactccattgtgccttactaaatatgggaatgtctaacttaaa tagctttgagatttcagctatgctagaggcttttattagnnnnnnnnnnnnnnnnnnnnn nnangttactaatatatctgtaacactattacagtattgctatttatattcattcagata taagatttgtacatattatcatcctataaagaaacggtatgacttaattttagaaagaaa attatattctgtttattatgacaaatgaaagagaaaatatatatttttaatggaaagttt gtagcatttttctaataggtactgccatatttttctgtgtgg

>37637_at HG-U95Av2 tccttaaagaactggctgatggggcaggaggtccaggcctgggctctnnnggncctecta gagggccattggagcttgcagctcagacccccnactttgagttttatttatttaaatagt agttggatgcttggcacgtcgtcctgtaataggaaacccttgcctcatcagttttcctga tttacaagtgcaatattttagccaatgccttgggagaagctgccatgcaaaggtggacac cattctccagcttcaggggatatgctcgtcccgggcaccggtggcaggcagctggccttc tggactaaggcagcctggggggacactgcagtctggctacacacagagatcntggcaccc cctgggtggagtgtccctcgggggctttgggaaagcatggcaccctcagaccacacagta gccaagttctggagcaa >37645_at HG-U95Av2 catttgcactactggaaggagttagatgttggtactagatactgaatgtaaacaaaggaa ttatggctggtaacataggtttttagtctaattgaatcccttaaactcagggagcattta taaatggacaaatgcttatgaaattaagatttgtaatatttctctctttttagagaaatt tgccaatttactttgttatttttccccaaaaagaatgggatgatcgtgtatttatttttt tacttcctcagctgtagacaggtccttttcgatggtacatatttctttgcctttataatc ttttatacagtgtcttacagagaaaagacataagcaaagactatgaggaatatttgcaag acatagaatagtgttggaaaatgtgcaatatgtgatnnnnnnnnnnnnnnntaggaaata ttctgtaatcttcagacctagaataatactagtcttataataggtttgtgactttcctaa atcaat >37695_at HG-U95Av2 gggcctgcgttaaaacctaattgctaatgcttcacaactaggagagcatgccgtcttgat gtttaaaaaacccagggtctccacccttcctttgatttgtgcaattctgtcttccacagt tccggagccttcagtgaggggtagctacatgccccatgcctgccctttctttccttcttt gctcactttactatgggtgtattttaatcttgtataaaaatatnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaacagatttgat ttgtgtttttgaaatgtcagtacattttgtgccactaacactgtgatgtataaaagagct gtttgaatgccttttaatgttgtgttttgtactctggaatcatatggaaaaagtttgatt tgtaatttcaatacatattttaaatgtannnnnnnnnacgtagtttgtccccccctttag cagggattcctttttaaagct >37701_at HG-U95Av2 cataaagactgaccttgaattcagcctnnnnnnnnnnnnnnnatcactcagaactattga ttcaaagttgggtagtgaatcaggaagccagtaactgactaggagaagctggtatcagaa cagcttccctcactgtgtacagaancgcaagaagggaataggtggtctgaacgtggtgtc tcactctgaaaagncaggaatgtaagatgatgaaagagancaatgtaatactgttggtnc caaaagcatttaaaatcaatagatctgggattatgtggccttaggtagctggttgtacat nctttnccctaaatcgatnccatngttanccacatagtagttttagtttagnnnnnnnnn nnnnnnnngtgtttactatgtgcaanggtattgaagttcttatgaccacagatcatcagt actgttgtctcatgtaatgctaaaacnnnnnnnnnnnnnnnntgcattgttaaaaatgat gtgtgaaatagaatgagtgctatggtgttgaaaactgcagtgtccgttatgagtgccaaa 97- 98677.doc 200533758 aatctgtcttgaaggcagctacactttgaagtggtct >37712_g_at HG-U95Av2 gaggatatccatcagccatttcaacaacatatggtaccgagtactctctgagtagtgcag acctgtcatctctgtctgggtttaacaccgccagcnnnnnncaccnnnnnnnnnnnnnnn nnnnnnnnnnnnnnacacctacataacatgccaccatctgccctcagtcagttgggagct tgcactagcactcatttatctcagagttcaaatctctccctgccttctactcaaagcctc aacatcaagtcagaacctgtttctcctcctagagaccgtaccaccaccccttcgagatac ccacaacacacgcgccacgaggcggggagatctcctgttgacagcttgagcagctgtagc agttcgtacgacgggagcgaccgagaggatcaccggaacgaattccactcccccattgga ctcaccagaccttcgccggacgaaagggaaagtccctcagtcaagcgcatgcgactttct gaaggatgggc >37745_s_at HG-U95Av2 ctgctgtaagctttcttaactgttttttgtaacaagcaaagagaatatggcaaatatttg tatattcccaanggggccgggtgctttcnnnnnnnnnnnnnnnatggatgaagtttcgct gggtgctcgtgactggccnagttttgtgcagctgactgtctcagccaaaccactgatctt ccctggaggccttnnnnnnnnncnnncnngcntnnncctgaggtccccnntnnccagtcn nnnnnnnnnnnnnnnnnnnnnnnnnntgttatgtacaggaggaccttttaaaaaaatcaa≫ 37637_at HG-U95Av2 tccttaaagaactggctgatggggcaggaggtccaggcctgggctctnnnggncctecta gagggccattggagcttgcagctcagacccccnactttgagttttatttatttaaatagt agttggatgcttggcacgtcgtcctgtaataggaaacccttgcctcatcagttttcctga tttacaagtgcaatattttagccaatgccttgggagaagctgccatgcaaaggtggacac cattctccagcttcaggggatatgctcgtcccgggcaccggtggcaggcagctggccttc tggactaaggcagcctggggggacactgcagtctggctacacacagagatcntggcaccc cctgggtggagtgtccctcgggggctttgggaaagcatggcaccctcagaccacacagta gccaagttctggagcaa > 37645_at HG-U95Av2 catttgcactactggaaggagttagatgttggtactagatactgaatgtaaacaaaggaa ttatggctggtaacataggtttttagtctaattgaatcccttaaactcagggagcattta taaatggacaaatgcttatgaaattaagatttgtaatatttctctctttttagagaaatt tgccaatttactttgttatttttccccaaaaagaatgggatgatcgtgtatttatttttt tacttcctcagctgtagacaggtccttttcgatggtacatatttctttgcctttataatc ttttatacagtgtcttacagagaaaagacataagcaaagactatgaggaatatttgcaag acatagaatagtgttggaaaatgtgcaatatgtgatnnnnnnnnnnnnnnntaggaaata ttctgtaatcttcagacctagaataatactagtcttataataggtttgtgactttcctaa atcaat > 37695_at H G-U95Av2 gggcctgcgttaaaacctaattgctaatgcttcacaactaggagagcatgccgtcttgat gtttaaaaaacccagggtctccacccttcctttgatttgtgcaattctgtcttccacagt tccggagccttcagtgaggggtagctacatgccccatgcctgccctttctttccttcttt gctcactttactatgggtgtattttaatcttgtataaaaatatnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaacagatttgat ttgtgtttttgaaatgtcagtacattttgtgccactaacactgtgatgtataaaagagct gtttgaatgccttttaatgttgtgttttgtactctggaatcatatggaaaaagtttgatt tgtaatttcaatacatattttaaatgtannnnnnnnnacgtagtttgtccccccctttag cagggattcctttttaaagct > 37701_at HG-U95Av2 cataaagactgaccttgaattcagcctnnnnnnnnnnnnnnnatcactcagaactattga ttcaaagttgggtagtgaatcaggaagccagtaactgactaggagaagctggtatcagaa cagcttccctcactgtgtacagaancgcaagaagggaataggtggtctgaacgtggtgtc tcactctgaaaagncaggaatgtaagatgatgaaagagancaatgtaatactgttggtnc caaaagcatttaaaatcaatagatctgggattatgtggccttaggtagctggttgtacat nctttnccctaaatcgatnccatngttanccacatagtagttttagtttagnnnnnnnnn nnnnnnnngtgtttactatgtgcaanggtattgaagttcttatgaccacagatcatcagt actgttgtctcatgtaatgctaaaacnnnnn nnnnnnnnnnntgcattgttaaaaatgat gtgtgaaatagaatgagtgctatggtgttgaaaactgcagtgtccgttatgagtgccaaa 97- 98677.doc 200533758 aatctgtcttgaaggcagctacactttgaagtggtct > 37712_g_at HG-U95Av2 gaggatatccatcagccatttcaacaacatatggtaccgagtactctctgagtagtgcag acctgtcatctctgtctgggtttaacaccgccagcnnnnnncaccnnnnnnnnnnnnnnn nnnnnnnnnnnnnnacacctacataacatgccaccatctgccctcagtcagttgggagct tgcactagcactcatttatctcagagttcaaatctctccctgccttctactcaaagcctc aacatcaagtcagaacctgtttctcctcctagagaccgtaccaccaccccttcgagatac ccacaacacacgcgccacgaggcggggagatctcctgttgacagcttgagcagctgtagc agttcgtacgacgggagcgaccgagaggatcaccggaacgaattccactcccccattgga ctcaccagaccttcgccggacgaaagggaaagtccctcagtcaagcgcatgcgactttct gaaggatgggc > 37745_s_at HG-U95Av2 ctgctgtaagctttcttaactgttttttgtaacaagcaaagagaatatggcaaatatttg tatattcccaanggggccgggtgctttcnnnnnnnnnnnnnnnatggatgaagtttcgct gggtgctcgtgactggccnagttttgtgcagctgactgtctcagccaaaccactgatctt ccctggaggccttnnnnnnnnncnnncnngcntnnncctgaggtccccnntnnccagtcn nnnnnnnnnnnnnnnnnnnnnnnnnntgttatgtacaggaggaccttttaaaa aaatcaa

gtttctattttttgctggtagtccgcatacccataccctctgtttttgaaaggcaaaggc caatcagtccccatttgtagcatggcaccagggtcttaggcctagtcctctcattcctcc caccctccgagatggtcagtgtgtcatgggaagcccacccccagctctgccagtgctctc tgggcctggctcccagtcagtggtggccacgatgcggtacagggcatccctccttcccat ctacgggtgttctcaataaacaatgtacagttgtttgggcccaga >37749—at HG-U95Av2 ctctgccagagtagtgaagctaattaaacacntttggtttctgaataaattgaactaaat ccaaactatttcctaaaatcacaggacattaaggaccaatagcatctgnnnnnnnnnnnn nnngttattagctgggaagaccaattctaacagcaaataacagtctgagactcctcatac ctcagtggttagaagcatgtctctcttgagctacagtagaggggaagggattgttgtgta gt c a agnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnt gcctgtcccagagaggctttccaatgtagetcagtaattcctgttactttacagacagga aagttccagaaactttaagaacaaactctgaaagacctatgagcaaatggtgctgaatac tttttttttaaagccacatttcattgtcttagtcaaagcaggattattaagtgattattt aaaattcgtttttttaaattagcaacttcaagtataacaactttgaaactgg >37785_at HG-U95Av2 ttgggggcctacagcagcctcaccttcagcttcatgcctcttccacacagcgtttccatg caggtcaggggatgggaggggtccctgagcccttcccttcccctctaaggaggcagcaac ggcagagtggggaantgganngnnnnnnnnnctnnntngnntnnnnnnnnccnngnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncagagccnaatgagaaggaaacctcatc tttgcatagcccatgccntcatggagaggtgacatcatacattcacatgcttctcaccta agtccccagggt >37823__at HG-U95Av2 cccaggtgcagtgtgacattattttattataacanccncaaagagattatttttaaataa tttaaagcataatatttcttaaaaagtatttaattatatttaagttgttgatgttttaac tctatctgtcatacatcctagtgaatgtaaaatgcaaaatcctggtgatgtgttttttgt ttttgttttcctgtgagctcaactaagttcacggcaaaatgtcattgttctccctcctac ctgtctgtagtgttgtggggtcctcccatggatcatcaaggtgaaacactttggtattct ttggcaatcagtgctcctgtaagtcaaatgtgtgctttgtactgc >37830一at HG-U95Av2 acctgcctgcgctctccagatatganccctgcanccaccccccacagcntgccctacccc acctacnntgcntcagcntnggacttctcagtgggtggagtgccagggaggaggaggcac acggagacctggggctcggggcccctggattcctgcatctgcatatgcgtatttgccaaa gacgacagggtgggctggggtgcgctccggaggaacccccggcactgatgggcttctgcc cctgcccttcctcacactgacactttgtccccacatggggtggggagcagagtgcccgcc ccgtggagatacnnccccagcgggggctgcgacatccatggccaccatggggcacctggc ggggcgggggtctgccggcctctgggcaaggcccctggagcatctcgcccaggcttttta taccttacaatgtaacttttttattttattttactctatgattattcaggaatattatct 98- 98677.doc 200533758 ctcagataagt >37841_at HG-U95Av2 gaaagcaggattccatcgctggaacaattacatgatggactggaaaaatcaatttaacga ttacactagcaagaaagaaagttgtgtgggtctctaattaatagatttaccctttataga acatattttcctttagatcaaggcaaaaatatcaggagcttttttacacacctactaaaa aagttattatgtagctgaaacaaaaatgccagaaggataatattgattcctcacatcttt aacttagtattttacctagcatttcaaaacccaaatggctagaacntgtttaattaaatt tcacaatataaagttctacagttaattatgtgcatattnnnnnnnnnnnnnnnnnnnnnt tctttctttccttaataaatttaagttttttccccccaaaattatcagtgctctgctttt agtcacgtgtattttca >37 94 4_at HG-U95Av2gtttctattttttgctggtagtccgcatacccataccctctgtttttgaaaggcaaaggc caatcagtccccatttgtagcatggcaccagggtcttaggcctagtcctctcattcctcc caccctccgagatggtcagtgtgtcatgggaagcccacccccagctctgccagtgctctc tgggcctggctcccagtcagtggtggccacgatgcggtacagggcatccctccttcccat ctacgggtgttctcaataaacaatgtacagttgtttgggcccaga > 37749-at HG-U95Av2 ctctgccagagtagtgaagctaattaaacacntttggtttctgaataaattgaactaaat ccaaactatttcctaaaatcacaggacattaaggaccaatagcatctgnnnnnnnnnnnn nnngttattagctgggaagaccaattctaacagcaaataacagtctgagactcctcatac ctcagtggttagaagcatgtctctcttgagctacagtagaggggaagggattgttgtgta gt c a agnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnt gcctgtcccagagaggctttccaatgtagetcagtaattcctgttactttacagacagga aagttccagaaactttaagaacaaactctgaaagacctatgagcaaatggtgctgaatac tttttttttaaagccacatttcattgtcttagtcaaagcaggattattaagtgattattt aaaattcgtttttttaaattagcaacttcaagtataacaactttgaaactgg > 37785_at HG-U95Av2 ttgggggcctacagcagcctcaccttcagcttcatgcctcttccacacagcgtttccatg caggtcaggggatgggaggggtccctgagcccttcccttcccctctaaggaggcagc aac ggcagagtggggaantgganngnnnnnnnnnctnnntngnntnnnnnnnnccnngnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncagagccnaatgagaaggaaacctcatc tttgcatagcccatgccntcatggagaggtgacatcatacattcacatgcttctcaccta agtccccagggt > 37823__at HG-U95Av2 cccaggtgcagtgtgacattattttattataacanccncaaagagattatttttaaataa tttaaagcataatatttcttaaaaagtatttaattatatttaagttgttgatgttttaac tctatctgtcatacatcctagtgaatgtaaaatgcaaaatcctggtgatgtgttttttgt ttttgttttcctgtgagctcaactaagttcacggcaaaatgtcattgttctccctcctac ctgtctgtagtgttgtggggtcctcccatggatcatcaaggtgaaacactttggtattct ttggcaatcagtgctcctgtaagtcaaatgtgtgctttgtactgc > 37830 a at HG-U95Av2 acctgcctgcgctctccagatatganccctgcanccaccccccacagcntgccctacccc acctacnntgcntcagcntnggacttctcagtgggtggagtgccagggaggaggaggcac acggagacctggggctcggggcccctggattcctgcatctgcatatgcgtatttgccaaa gacgacagggtgggctggggtgcgctccggaggaacccccggcactgatgggcttctgcc cctgcccttcctcacactgacactttgtccccacatggggtggggagcagagtgcccgcc ccgtggagatacnnccccagcgggggctgcgacatccatggccaccatggggcacctggc ggggcgggggtctgccggcctctgggcaaggccc ctggagcatctcgcccaggcttttta taccttacaatgtaacttttttattttattttactctatgattattcaggaatattatct 98- 98677.doc 200533758 ctcagataagt > 37841_at HG-U95Av2 gaaagcaggattccatcgctggaacaattacatgatggactggaaaaatcaatttaacga ttacactagcaagaaagaaagttgtgtgggtctctaattaatagatttaccctttataga acatattttcctttagatcaaggcaaaaatatcaggagcttttttacacacctactaaaa aagttattatgtagctgaaacaaaaatgccagaaggataatattgattcctcacatcttt aacttagtattttacctagcatttcaaaacccaaatggctagaacntgtttaattaaatt tcacaatataaagttctacagttaattatgtgcatattnnnnnnnnnnnnnnnnnnnnnt tctttctttccttaataaatttaagttttttccccccaaaattatcagtgctctgctttt agtcacgtgtattttca > 37 94 4_at HG-U95Av2

ccactttgatgctatttgggttatgatggggcaagatggcagaggtattgggtttttttg tttttttccattcctctctacttctgtttcctagctttttctttctggagtttaagtaca gtgatggttggcttgagnnccttttnaaatctngcccagtataaacattagcctgcttaa tatttagacatttataggtagaattctgagcactcaactcatgtttggcattttaaagta aaaacaagtgtgacttcgaggaccaaagaaattgtcagetatacatttatetttatgaac tcatttatattcctttttaatgactcgttgttctaacatttcctagaagtgttcttataa aggtctaatgtatccacaggctgttgtcttattagtaaatgcaaagtaatgactttgtct gttttactctagtctttagtacttcaaaattaccttttcatatccatgatcttgagtcca tttgggggatttttaagaatttgatgtatttcaatacactgttcaaaattaaattgttta attttatgtatgagtatgtatgttcctgaagttggtcctatt >38022_s__at HG-U95Av2 tcaacaagggcctggtggacaagatcatggtggaccgcnnnnnnnnnnnnnnnnnnnnnn nnnnnggcttcgaggacccacgcaccaagaccaagatgtcggccgcccaggccctgaaga agggctggctctactacgaggccggccagcgcttcctggaggtgcagtacctgaccggcg gcttgatcgagcccgacacgccgggccgcgtgcccctggacgaggccctgcagnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngctggaccgcagcatggtgg aggagggcacggggctnnnnnnnnnnnnnnnnnnnnnnnnnnccaccaagggctactaca gcccctacagcg >38062_at HG-U95Av2 aaatcagtgacctgaagcaagaaatcttgccttttaatgtatcattaattagggctgctg tgatattgtcagcttgcattaacaattagaagatagagaacccgccatcagggtgnnnnn nnnnnnnnnnnnngactacacttggtagttttccaccatttaaagaactggtaaatatga aacatttgttgagttaccagaattgccattaacagtgttttctttcccatattccatgct ttctgcctctgtgtatatatataatatatatgtatatgactgtgctgtgtatttatcgaa gctagtaagcaataatttatatgtaaaaatggccaagcaatataaggttaaaacttatat aagtaacccttaccttatcttgtattttcaattttttttnaaaactgcttttccaaatat gagactatg >38066_at HG-U95Av2 ctgatctatacaaattttcagaaggttattttctttatcattgctaaactgatgacttac catgggatggggtccagtcccatgaccttnggggtancaattgtaaacctagagttttat caactttggtgaacagttttggcataatagtcaatttctacttctggaagtcatctcatt ccactgttggtattatataattcaaggagaatatgataaaacactgccctcttgtggtgc attgaaagaagagatgagaaatgatgaaaaggttgcctgaaaaatgggagacagcctctt acttgccaagaaaatgaagggattggaccgagctggaaaacctcctttaccagatgctga ctggcactggtggtttttgctctcg >38129_at HG-U95Av2 atctccagaaagtggtattccataaaacctaccaactcatggattcccaagatgtgagct ttttacataatgaaagaacccagcaattctgtctcttaatgcaatgacactattcataga ctttgattttatttataagccacttgctgcatgaccctccaagtagacctgtggcttaaa ataaagaaaatgcagcaaaaagaannnnanagaaatatttggtggttttttttttttnnn naaacatccacagttaaggttgggccagctacctttgggnntgacccccnccattgccat aacatcctgctccattccctctaagatgtaggaagaattcggatccttaccattggnaat cttccatcgaacatactcaaacacttttggnccaggatttgagtctctgcatgacatata 99- 98677.doc 200533758 cttgattaaaaggttattactaacctgttaaaaatnnnnnnnnnnnnnnntttaacagac accctaaaagtctccttttcnacatagttgaagacagcaacatcttcactgaatgttttg >38130_s_at HG-U95Av2 catattgcttttgctgcattagaagctgtttgtttccaaactcgagagattttggatgcc atgaatcgagactgtggaattccactcagtcatttgcaggttgatggaggaatgaccagc aacaaaattcttatgcagctacaagcagacattctgtatattccagtnnnnnnnnnnnnn nnnnccgaaaccactgcactgggtgctgccatggcggcaggggctgcagaaggagtcgac gtatggagtcttgaacctgaggatttgtccgccgtcacgatggagcggtttgaacctcag a >38152_at HG-U95Av2 agtgctacatgatgccggtgttgaccttccttcaagaggaccaaatgatttcagaattta gttttagcagctgaaaatttatttctccctgtaaacgttaaaaacagttttccaaataac atcaacaacnnnnnnnnnnnnnnnnttcttattctttctaaactacaacgaacacaagaa ttgaatagtaagatgttaattttttttactataaacatttttagagaagtaaaacatgct gaaaactacacaaattataagcatacaactggactcattatcacagtgaatgcactgtgt gatcgccacataggtaaaaactggaatggtcgtaggcctctccatctgtacccttttcca tcatgtcctattccctgtcactacacactaaaactttcctgacttacaataccatgggttccactttgatgctatttgggttatgatggggcaagatggcagaggtattgggtttttttg tttttttccattcctctctacttctgtttcctagctttttctttctggagtttaagtaca gtgatggttggcttgagnnccttttnaaatctngcccagtataaacattagcctgcttaa tatttagacatttataggtagaattctgagcactcaactcatgtttggcattttaaagta aaaacaagtgtgacttcgaggaccaaagaaattgtcagetatacatttatetttatgaac tcatttatattcctttttaatgactcgttgttctaacatttcctagaagtgttcttataa aggtctaatgtatccacaggctgttgtcttattagtaaatgcaaagtaatgactttgtct gttttactctagtctttagtacttcaaaattaccttttcatatccatgatcttgagtcca tttgggggatttttaagaatttgatgtatttcaatacactgttcaaaattaaattgttta attttatgtatgagtatgtatgttcctgaagttggtcctatt > 38022_s__at HG-U95Av2 tcaacaagggcctggtggacaagatcatggtggaccgcnnnnnnnnnnnnnnnnnnnnnn nnnnnggcttcgaggacccacgcaccaagaccaagatgtcggccgcccaggccctgaaga agggctggctctactacgaggccggccagcgcttcctggaggtgcagtacctgaccggcg gcttgatcgagcccgacacgccgggccgcgtgcccctggacgaggccctgcagnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngctggaccgcagcatggtgg aggagggcacggggct nnnnnnnnnnnnnnnnnnnnnnnnnnccaccaagggctactaca gcccctacagcg > 38062_at HG-U95Av2 aaatcagtgacctgaagcaagaaatcttgccttttaatgtatcattaattagggctgctg tgatattgtcagcttgcattaacaattagaagatagagaacccgccatcagggtgnnnnn nnnnnnnnnnnnngactacacttggtagttttccaccatttaaagaactggtaaatatga aacatttgttgagttaccagaattgccattaacagtgttttctttcccatattccatgct ttctgcctctgtgtatatatataatatatatgtatatgactgtgctgtgtatttatcgaa gctagtaagcaataatttatatgtaaaaatggccaagcaatataaggttaaaacttatat aagtaacccttaccttatcttgtattttcaattttttttnaaaactgcttttccaaatat gagactatg > 38066_at HG-U95Av2 ctgatctatacaaattttcagaaggttattttctttatcattgctaaactgatgacttac catgggatggggtccagtcccatgaccttnggggtancaattgtaaacctagagttttat caactttggtgaacagttttggcataatagtcaatttctacttctggaagtcatctcatt ccactgttggtattatataattcaaggagaatatgataaaacactgccctcttgtggtgc attgaaagaagagatgagaaatgatgaaaaggttgcctgaaaaatgggagacagcctctt acttgccaagaaaatgaagggattggaccgagctggaaaacctcctttaccagatgctga ctggcactggtggtttttgctctcg > 38129_at HG-U95Av2 atctccagaaagtggtattccataaaacctaccaactcatggat tcccaagatgtgagct ttttacataatgaaagaacccagcaattctgtctcttaatgcaatgacactattcataga ctttgattttatttataagccacttgctgcatgaccctccaagtagacctgtggcttaaa ataaagaaaatgcagcaaaaagaannnnanagaaatatttggtggttttttttttttnnn naaacatccacagttaaggttgggccagctacctttgggnntgacccccnccattgccat aacatcctgctccattccctctaagatgtaggaagaattcggatccttaccattggnaat cttccatcgaacatactcaaacacttttggnccaggatttgagtctctgcatgacatata 99- 98677.doc 200533758 cttgattaaaaggttattactaacctgttaaaaatnnnnnnnnnnnnnnntttaacagac accctaaaagtctccttttcnacatagttgaagacagcaacatcttcactgaatgttttg > 38130_s_at HG-U95Av2 catattgcttttgctgcattagaagctgtttgtttccaaactcgagagattttggatgcc atgaatcgagactgtggaattccactcagtcatttgcaggttgatggaggaatgaccagc aacaaaattcttatgcagctacaagcagacattctgtatattccagtnnnnnnnnnnnnn nnnnccgaaaccactgcactgggtgctgccatggcggcaggggctgcagaaggagtcgac gtatggagtcttgaacctgaggatttgtccgccgtcacgatggagcggtttgaacctcag a > 38152_at HG-U95Av2 agtgctacatgatgccggtgttgaccttccttcaagaggaccaaatgatttcagaattta gttttagcagctgaaaatttatttctccctgtaaacgttaaaaacagttttccaa ataac atcaacaacnnnnnnnnnnnnnnnnttcttattctttctaaactacaacgaacacaagaa ttgaatagtaagatgttaattttttttactataaacatttttagagaagtaaaacatgct gaaaactacacaaattataagcatacaactggactcattatcacagtgaatgcactgtgt gatcgccacataggtaaaaactggaatggtcgtaggcctctccatctgtacccttttcca tcatgtcctattccctgtcactacacactaaaactttcctgacttacaataccatgggtt

atttatgcttg >38169_s__at HG~U95Av2 ggatcgtctcccagggtaacctcgaagagtgagtnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnctcttctgcccctcccttctgccaacacagcagtcagcttct ctcgtgagctttctggtaggannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngctg tttcttgttctcttcgttgccatcgttctcaccnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngc a tc 11 gg t gaac atttacttgatggtccagttaagtgcagacacttgggtcagattcagcatttggatggca attggcttcctgatttacttttcttatggcattagacacagcctggagggtcatctgaga gatgaaaacaatgaagaagatgcttatccagacaacgttcatgcagcannnnnnnnnnnn nnnnnnnttcaagcaaatgaccatcacccaagaaatctcagttcacctttcatattccat gaaaagacaagtgaattc >38177一at HG-U95Av2 ggcgctgtcctgaatccccacgaggccctggctcagcctcttcccaccacaggcacacca gggtcagaaggggggacggtgaagaactatgagacagctgtccaattttnctggaannnn nnnaannannannnnnnnncnannnnnaaggattggtgcgactgggccatgattagcagg ccttatageaccctgcgagattgcctggagcactttgnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnatctttgagactcaccagatccactttgccaactgc tccctggntgcagcccaccttctctgaccccccagaggatgtactcctggccatgateat agcccccatctgcctcatccccttcctcatcactcttgtagtatggaggagtaaagacag tgaggcccaggcntagggggcnacgagcttctcaacaaccatgttactccacttccccac ccccaccaggcctccctcctcccctcctactcccttttctcactctcatccccaccacag nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng gt c atggcacaagttctgtaatcttc a >38222_at HG-U95Av2 cacccagaagaagttccgccggcgaccacatgagctcctacagaaactcacagccaaatg gcagaggcagggtcgctgagtcctccaggtcctgggcagccttcatatttgccattgtgt :：cggggcaccaggagccccaccaaccccaaaccatgcggagaattagagttcagctcagc tgggcatggagttaagatccctcacaggacccagaagctcaccaaaaactatttcttcag ccccttctctggcccagaccctgtgggcatggagatggacagacctgggcctggctcttg agaggtcccagtcagccatggagagctggggaaaccacattaaggtgctcacaaaaatac agtgtgacgtgtactgtcaa >38223_at HG-U95Av2 gcaagacagcagctgctatgcacacntggagtccaccataccaaagcacgaaccagactg tttcttnggggtcagccctanaccgngatttcagtctnnnnnnnnnnnnnnncatctggc taaacaacctgacaaactgtggccaggggaaccgacacaaccctcaagcatttctatgta ttgagaattgtcagtgccctaaggtatccattggttcccttgatgccaacttacaatttt 100- 98677.doc 200533758 taccggatttgctgaaatgggcacnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ngaacacaatgtctcatactaaccaagaagcaagaaaagccccatgctttcatttttcac ttggagtgacaatgggagaggtcaggaatcaagttcactttcaagatctaagggagtcca ctatctgtgcaattgtatttggcttttttttgcactgtttcaatgctggtaattgaaacc attttaatatatttggttgtattcactttatatgtccttccaaaaatgttgttgtgtaca naccatgctttcaatgttggcttcca >38234_at HG-U95Av2 cagccgagcgttcagggctgcgctccggccggctgagagggcacgtgccccgtcacagtc tggactcctgggcctggattgatgtgtctcacagactcggaagggttctgctcctcctcc tccccctgaacaatgctggcagttgctacaaatagatttattggaggcttatggctccgg ttcccccacanacccgctcatgagtctctgtttgttcttcccttttcttttgccctgtcc ctcaccttgggtcgggggtgctggagtggaccacaatgttgtgctgggggatgggggggt ctctctttgccgattgtgcagtgcacaagatttgtgaaaaatgtaaataacagactecta ttgcg >38247_at HG-U95Av2 cagactgggaacagggcccaggaatctgtgtggtacaaacctgcatggtgtttatgcaca cagagatttgagaaccattgttctgaatgctgcttccatttgacaaagtgccgtgataatatttatgcttg > 38169_s__at HG ~ U95Av2 ggatcgtctcccagggtaacctcgaagagtgagtnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnctcttctgcccctcccttctgccaacacagcagtcagcttct ctcgtgagctttctggtaggannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngctg tttcttgttctcttcgttgccatcgttctcaccnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngc a tc 11 gg t gaac atttacttgatggtccagttaagtgcagacacttgggtcagattcagcatttggatggca attggcttcctgatttacttttcttatggcattagacacagcctggagggtcatctgaga gatgaaaacaatgaagaagatgcttatccagacaacgttcatgcagcannnnnnnnnnnn nnnnnnnttcaagcaaatgaccatcacccaagaaatctcagttcacctttcatattccat gaaaagacaagtgaattc > 38177 a at HG-U95Av2 ggcgctgtcctgaatccccacgaggccctggctcagcctcttcccaccacaggcacacca gggtcagaaggggggacggtgaagaactatgagacagctgtccaattttnctggaannnn nnnaannannannnnnnnncnannnnnaaggattggtgcgactgggccatgattagcagg ccttatageaccctgcgagattgcctggagcactttgnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnatctttgagactcaccagatccactttgccaact gc tccctggntgcagcccaccttctctgaccccccagaggatgtactcctggccatgateat agcccccatctgcctcatccccttcctcatcactcttgtagtatggaggagtaaagacag tgaggcccaggcntagggggcnacgagcttctcaacaaccatgttactccacttccccac ccccaccaggcctccctcctcccctcctactcccttttctcactctcatccccaccacag nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng gt c atggcacaagttctgtaatcttc a > 38222_at HG-U95Av2 cacccagaagaagttccgccggcgaccacatgagctcctacagaaactcacagccaaatg gcagaggcagggtcgctgagtcctccaggtcctgggcagccttcatatttgccattgtgt :: cggggcaccaggagccccaccaaccccaaaccatgcggagaattagagttcagctcagc tgggcatggagttaagatccctcacaggacccagaagctcaccaaaaactatttcttcag ccccttctctggcccagaccctgtgggcatggagatggacagacctgggcctggctcttg agaggtcccagtcagccatggagagctggggaaaccacattaaggtgctcacaaaaatac agtgtgacgtgtactgtcaa > 38223_at HG-U95Av2 gcaagacagcagctgctatgcacacntggagtccaccataccaaagcacgaaccagactg tttcttnggggtcagccctanaccgngatttcagtctnnnnnnnnnnnnnnncatctggc taaacaacctgacaaactgtggccaggggaaccgacacaaccctcaagcatttctatgta ttgagaattgtcagtgccctaaggtatccattggttcccttgatgccaacttacaatttt 100- 98 677.doc 200533758 taccggatttgctgaaatgggcacnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ngaacacaatgtctcatactaaccaagaagcaagaaaagccccatgctttcatttttcac ttggagtgacaatgggagaggtcaggaatcaagttcactttcaagatctaagggagtcca ctatctgtgcaattgtatttggcttttttttgcactgtttcaatgctggtaattgaaacc attttaatatatttggttgtattcactttatatgtccttccaaaaatgttgttgtgtaca naccatgctttcaatgttggcttcca > 38234_at HG-U95Av2 cagccgagcgttcagggctgcgctccggccggctgagagggcacgtgccccgtcacagtc tggactcctgggcctggattgatgtgtctcacagactcggaagggttctgctcctcctcc tccccctgaacaatgctggcagttgctacaaatagatttattggaggcttatggctccgg ttcccccacanacccgctcatgagtctctgtttgttcttcccttttcttttgccctgtcc ctcaccttgggtcgggggtgctggagtggaccacaatgttgtgctgggggatgggggggt ctctctttgccgattgtgcagtgcacaagatttgtgaaaaatgtaaataacagactecta ttgcg > 38247_at HG-U95Av2 cagactgggaacagggcccaggaatctgtgtggtacaaacctgcatggtgtttatgcaca cagagatttgagaaccattgttctgaatgctgcttccatttgacaaagtgccgtgataat

ttttgaaaagagaagcaaacaatggtgtctcttttatgttcagcttataatgaaatctgt ttgttgacttattaggactttgaattatttctttattaaccctctgagtttttgtatgta ttattattaaagaaaaatgcaatcaggattttaaacatgtaaatacaaattttgtataac ttttgatgacttcagtgaaattttcaggtagtctgagtaatagattgttttgccacttag aatagcatttgccacttagtattttaaaaaataattgttggagtatttattgtcagtttt gttcacttgttatctaatacaaaattataaannnnnnnnnnnnnnnngaccacatctctt tggaaaatagtttgcaacatatttaagagatacttgatgccaaaatgactttatacaacg >382 67__at HG-U95Av2 gttctaactagtaatcttggccctattcattacatcctctgcttgtcattctgctaattt atgaagatagtttattatagtctgtacttcagttctcatcttgtaaataatgcttaacat aaacttgtacttacactgaaatccaaaatagtcatgtttctgcagtattctgtagccaac ttaaacctgtgctttcatgtttaagaaatgagaaattgtgccaaagatagcagaagagta gataagtgctcagtattgacgacctacatctgaaatctacancataatgatactgaattg ttatgtaaacatcataaatagtaaataatgattcaatgtgaattttaaaatgcaaatatt gctattgtttataggaaataaatctaaatataaatgaaannnaannnannaantttatct tgggctaaatggttctaccccttactaggttgccccaattagtggcactagttggcagag c t g11 c annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnac tgctgttaactcataaaagagaagagtgttccatttcagtctcaataa >38268_at HG-U95Av2 ctcatgcatagacaagtgttttgggtttttaaaaaaaatattctgtcattggttacaaat ttttactcaggctttctattggcatggatttcctttgacctctcannnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnccccagttaatgtgccaaaatgtcaatttttaacttatc tccagccaatttcaaagaaaacagaccagcatagnttctgncnatnacngttttnagntg ggcatagggnttggaagaaagggagaaggattcttttttcaatgtactgtattgggacgc tggtaactgttaacccagtgttcagcatagagctatatatatatatatatnngtatatat ttattatttteatatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaatgtgaaataa agagttctccttgtacttgaataataaccacgnttccaacccaggtctgctttngggctt atcagaactcctttctaag >38276_at HG-U95Av2 ccggagccataactgctgcagtttgggcccaggctatgtgctcttctggtgccctaggga ctgctgtggccagagcctggggccagccagtacagtcctgagccgaggaggagggactgc aagtggaagagagccagtctggaaggaagagctttccaggtggacagggcttcttggaag acccccaaagccccaggtatcctgggtgaagcctgtttgcctctcttgaaaatggcaggt gc tc 11nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna gt ag g aage at g ga c t ctcctgagtgagaagagactgaaataggagcaagcagaaccctgagaggtgtcccatctt attgctgttgaggaccctgaaacaccgttgtttaaagacttcacacagaaggctctgaac tgagccactggggaa >38278 at HG-U95Av2 101 - 98677.doc 200533758 gtaggccagcccatggtgttgtgtacactgtggagtcgacaggggcctacnnnnnnnnnn nnnnnctgccagggggctctgaactagtgcctgctacccaggacacccgggccatncccc tggctgggcagcctggcacaagtgaagaagaaggcagtgggaaaactgggtttatctcaa ggcagcagcctgagcccaggagcagaggacccagttgttataaggcgctgggagaggatn ggcagctcccactgccccagagcggagctcgaagcacccaggttgcccacggaa >38287_at HG-U95Av2 actggaggaacctccacttgttttggctgctgcaaatgtggtgagaaatatcagctataa atatcgagaggacttgtctgcacatctcatggtagctggctgggaccaacgtgaaggagg tcaggtatatggaaccctgggaggaatgctgactcgacagccttttgccattggtggctc cggcagcacctttatctatggttatgtggatgcagcatataagccaggcatgtctcccga ggagtgcaggcgcttcaccacagacgctattgctctggccatgagccgggatggctcaag cgggggtgtcatctacctggtcactannnnnnnnnnnnnnnnggaccatcgagtcatctt gnnnnnnnnnnnnnnnnnnnnctatgatgagtgaaccttccccagacttctctttcttat tttgtaataaactctctagggcca >38298_at HG-U95Av2ttttgaaaagagaagcaaacaatggtgtctcttttatgttcagcttataatgaaatctgt ttgttgacttattaggactttgaattatttctttattaaccctctgagtttttgtatgta ttattattaaagaaaaatgcaatcaggattttaaacatgtaaatacaaattttgtataac ttttgatgacttcagtgaaattttcaggtagtctgagtaatagattgttttgccacttag aatagcatttgccacttagtattttaaaaaataattgttggagtatttattgtcagtttt gttcacttgttatctaatacaaaattataaannnnnnnnnnnnnnnngaccacatctctt tggaaaatagtttgcaacatatttaagagatacttgatgccaaaatgactttatacaacg > 382 67__at HG-U95Av2 gttctaactagtaatcttggccctattcattacatcctctgcttgtcattctgctaattt atgaagatagtttattatagtctgtacttcagttctcatcttgtaaataatgcttaacat aaacttgtacttacactgaaatccaaaatagtcatgtttctgcagtattctgtagccaac ttaaacctgtgctttcatgtttaagaaatgagaaattgtgccaaagatagcagaagagta gataagtgctcagtattgacgacctacatctgaaatctacancataatgatactgaattg ttatgtaaacatcataaatagtaaataatgattcaatgtgaattttaaaatgcaaatatt gctattgtttataggaaataaatctaaatataaatgaaannnaannnannaantttatct tgggctaaatggttctaccccttactaggttgccccaattagtggcactagttggcagag c t g11 c annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnac tgctgttaactcataaaagagaagagtgttccatttcagtctcaataa > 38268_at HG-U95Av2 ctcatgcatagacaagtgttttgggtttttaaaaaaaatattctgtcattggttacaaat ttttactcaggctttctattggcatggatttcctttgacctctcannnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnccccagttaatgtgccaaaatgtcaatttttaacttatc tccagccaatttcaaagaaaacagaccagcatagnttctgncnatnacngttttnagntg ggcatagggnttggaagaaagggagaaggattcttttttcaatgtactgtattgggacgc tggtaactgttaacccagtgttcagcatagagctatatatatatatatatnngtatatat ttattatttteatatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaatgtgaaataa agagttctccttgtacttgaataataaccacgnttccaacccaggtctgctttngggctt atcagaactcctttctaag > 38276_at HG-U95Av2 ccggagccataactgctgcagtttgggcccaggctatgtgctcttctggtgccctaggga ctgctgtggccagagcctggggccagccagtacagtcctgagccgaggaggagggactgc aagtggaagagagccagtctggaaggaagagctttccaggtggacagggcttcttggaag acccccaaagccccaggtatcctgggtgaagcctgtttgcctctcttgaaaatggcaggt gc tc 11nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna gt ag g aage at g ga c t ctcctgagtgagaagagactgaaataggagcaagcagaaccctgagaggtgtcccatctt attgctgttgaggac cctgaaacaccgttgtttaaagacttcacacagaaggctctgaac tgagccactggggaa > 38278 at HG-U95Av2 101 - 98677.doc 200533758 gtaggccagcccatggtgttgtgtacactgtggagtcgacaggggcctacnnnnnnnnnn nnnnnctgccagggggctctgaactagtgcctgctacccaggacacccgggccatncccc tggctgggcagcctggcacaagtgaagaagaaggcagtgggaaaactgggtttatctcaa ggcagcagcctgagcccaggagcagaggacccagttgttataaggcgctgggagaggatn ggcagctcccactgccccagagcggagctcgaagcacccaggttgcccacggaa > 38287_at HG-U95Av2 actggaggaacctccacttgttttggctgctgcaaatgtggtgagaaatatcagctataa atatcgagaggacttgtctgcacatctcatggtagctggctgggaccaacgtgaaggagg tcaggtatatggaaccctgggaggaatgctgactcgacagccttttgccattggtggctc cggcagcacctttatctatggttatgtggatgcagcatataagccaggcatgtctcccga ggagtgcaggcgcttcaccacagacgctattgctctggccatgagccgggatggctcaag cgggggtgtcatctacctggtcactannnnnnnnnnnnnnnnggaccatcgagtcatctt gnnnnnnnnnnnnnnnnnnnnctatgatgagtgaaccttccccagacttctctttcttat tttgtaataaactctctagggcca > 38298_at HG-U95Av2

ataccacttgtcagggcacaggggactggctgggccccnagggntgctccccacttgcag cacaatgccttctccacctgccctcccactcttccagtccaatccacgctgtcttctgtt gcaggactaacctttgagaaatccttttgtgaagtcattgcctgctcaagaatgtacagt ggctccccaatgccttggaggccataaggccagccagttctagctctctattacctgtcc ccactcaactgactcatacc t gt nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc g at gatcgtcacctctgtgcctgagttctccctgttgtctcaaagcggtacccatcctccccc agaagctgtccccagcgagcctcccttctttgtttgaattctctaataagagcaacnnnn nnnnnnnnnnntagaacacatttacagtattactattttctaggatataaagtgccatat atatttttaattccaatattaataaatgtatgccaaacaacaannaaaaaaaaaaannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnncagctgcaaggaaacacatgagaac >38299_at HG-U95AV2 tgggcacctcagattgttgttgttaatgggcattccttcttctggtcagaaacctgtcca ctgggcacagaacttatgttgttctctatggagaactaaaagtatgagcgttaggacact attttaattatttttaatttattaatatttaaatatgtgaagctgagttaatttatgtaa gtcatatttatatttttaagannnnnnnnnnnnnnnnnnnnntgtattagttttgaaata ataatggaaagtggctatgcagtttgaatatcctttgtttcagagccagatcatttcttg gaaagtgtaggcttacctcaaataa >38315_at HG-U95Av2 agcttgcagggagtaaagcaggcccgcctccctttcttcccatccacatactcctcttct gctttccagtgactccaccagtttgatgtgggaagtgttagcttcctttccttcttccat cccttcttccatctttccagctgtcaaatccaatccagtctctaacctanatgcagatca tttatttaaaagtaccaaacataacccagagtntgtggaatatgggcaacatatatatag ccttctgtatttaacgatcttctgcttcttaaccgtaccagttttctatttataactctt atctatccatgatgttttaaagtctccacttgctgttatttacaaacgacagtgcattca gcagcccagtgccgtgagccctgacagatgccgtatttctgagtgcttccatgtgannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttacctttgga ctgcaacaaaaaatgtgaaaatgaagatttatttcttttaatttacttaaaaagaaacct ctgtgctagcaataaagcatttat >38326_at HG-U95Av2 gacaggctctccagaagcaagccctgcaggagaaaggcaagcagcaggacacggtcctcg gcggccgggccctgtccaaccggcagcacgcctcctaggaactgtgggagaccagcggag tgggagggagacgcagtagacagagacagaccgagaaggaagggagagacagagggggcg cgcgcacaggagcctgactccgctgggagagtgcaggagcacgtgctgttttttatttgg acttaacttcagagaaaccgctgacatctagaactgacctaccacaagcatccaccaaag gagtttgggattgagttttnctgctgtgcagcactgcattgtcatgacatttccaacact gtgtgaattatctaaatgcgtctaccattttgcactagg >38332_at HG-U95Av2 cagggtcttgctagtgagctggaccagtgaggcctaccccacacctgggctctccacagc cccatcaaagaacagagaggaggaggagggagaaatggccaccacatcaccccagagaaa tttctggaatctgattgagtctccactccacaagcactcagggttccccagcagctcctg 102- 986”7.doc 200533758 tgtgttgtgtgcaggatctgtttgcccactcggcccaggaggtcagcagtctgttcttgg ctgggtcaactctgcttttcccgcaacctggggttgtcgggggagcgctggcccgnacgc agtggcactgctgtggctttcagggctggnnnnnnnnnnnnnnngaagcctcctgtctcc agctctctccaggacaggcccagtcctctgaggcacggcggctctgttcaagcactttat gcggcaggggaggccgccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngcatttctcctcagagaagcg ctgtgctaaggtgatcgaggaccagacatt >38430_at HG-U95Av2 gatgcttttgtaggtacctggaaacttgtctccannnnnnnnnnnnnnnnnnnnnnnnaa gaagtaggagtnggcttnnncnncnaggaaagtggctggcatggccaaacctaacatgat catcagtgtgaatggggatgtgatcanccattaaatctgaaagtacctttaaaaatactg agatttcctteatactgggccaggaatttgacgaagtncactgncagatgacaggaaagt caagagcaccataaccttagatgggggtgtcctggtacatgtgcagaaatgggatggaaa atcaaccaccataaagagaaaacgagaggatgataaactggtggtggaatgcgtcatgaa aggcgtcacttccacgagagtttatgagagagcataagccaagggacgttgacctggact gaagttcgcattgaactctacaaataccacttgtcagggcacaggggactggctgggccccnagggntgctccccacttgcag cacaatgccttctccacctgccctcccactcttccagtccaatccacgctgtcttctgtt gcaggactaacctttgagaaatccttttgtgaagtcattgcctgctcaagaatgtacagt ggctccccaatgccttggaggccataaggccagccagttctagctctctattacctgtcc ccactcaactgactcatacc t gt nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc g at gatcgtcacctctgtgcctgagttctccctgttgtctcaaagcggtacccatcctccccc agaagctgtccccagcgagcctcccttctttgtttgaattctctaataagagcaacnnnn nnnnnnnnnnntagaacacatttacagtattactattttctaggatataaagtgccatat atatttttaattccaatattaataaatgtatgccaaacaacaannaaaaaaaaaaannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnncagctgcaaggaaacacatgagaac > 38299_at HG-U95AV2 tgggcacctcagattgttgttgttaatgggcattccttcttctggtcagaaacctgtcca ctgggcacagaacttatgttgttctctatggagaactaaaagtatgagcgttaggacact attttaattatttttaatttattaatatttaaatatgtgaagctgagttaatttatgtaa gtcatatttatatttttaagannnnnnnnnnnnnnnnnnnnntgtattagttttgaaata ataatggaaagtggctatgcagtttgaatatcctttgtttcagagccagatcatttcttg gaaagtgtaggcttacctcaaataa > 38315_at HG-U95Av2 agcttgcagggagt aaagcaggcccgcctccctttcttcccatccacatactcctcttct gctttccagtgactccaccagtttgatgtgggaagtgttagcttcctttccttcttccat cccttcttccatctttccagctgtcaaatccaatccagtctctaacctanatgcagatca tttatttaaaagtaccaaacataacccagagtntgtggaatatgggcaacatatatatag ccttctgtatttaacgatcttctgcttcttaaccgtaccagttttctatttataactctt atctatccatgatgttttaaagtctccacttgctgttatttacaaacgacagtgcattca gcagcccagtgccgtgagccctgacagatgccgtatttctgagtgcttccatgtgannnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttacctttgga ctgcaacaaaaaatgtgaaaatgaagatttatttcttttaatttacttaaaaagaaacct ctgtgctagcaataaagcatttat > 38326_at HG-U95Av2 gacaggctctccagaagcaagccctgcaggagaaaggcaagcagcaggacacggtcctcg gcggccgggccctgtccaaccggcagcacgcctcctaggaactgtgggagaccagcggag tgggagggagacgcagtagacagagacagaccgagaaggaagggagagacagagggggcg cgcgcacaggagcctgactccgctgggagagtgcaggagcacgtgctgttttttatttgg acttaacttcagagaaaccgctgacatctagaactgacctaccacaagcatccaccaaag gagtttgggattgagttttnctgctgtgcagcactgcattgtcatgacatttccaacact gtgtgaattatctaaatgcgtctaccattttgcactagg > 38332_a t HG-U95Av2 cagggtcttgctagtgagctggaccagtgaggcctaccccacacctgggctctccacagc cccatcaaagaacagagaggaggaggagggagaaatggccaccacatcaccccagagaaa tttctggaatctgattgagtctccactccacaagcactcagggttccccagcagctcctg 102- 986 "7.doc 200533758 tgtgttgtgtgcaggatctgtttgcccactcggcccaggaggtcagcagtctgttcttgg ctgggtcaactctgcttttcccgcaacctggggttgtcgggggagcgctggcccgnacgc agtggcactgctgtggctttcagggctggnnnnnnnnnnnnnnngaagcctcctgtctcc agctctctccaggacaggcccagtcctctgaggcacggcggctctgttcaagcactttat gcggcaggggaggccgccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngcatttctcctcagagaagcg ctgtgctaaggtgatcgaggaccagacatt > 38430_at HG-U95Av2 gatgcttttgtaggtacctggaaacttgtctccannnnnnnnnnnnnnnnnnnnnnnnaa gaagtaggagtnggcttnnncnncnaggaaagtggctggcatggccaaacctaacatgat catcagtgtgaatggggatgtgatcanccattaaatctgaaagtacctttaaaaatactg agatttcctteatactgggccaggaatttgacgaagtncactgncagatgacaggaaagt caagagcaccataaccttagatgggggtgtcctggtacatgtgcagaaatgggatggaaa atcaaccaccataaagagaaaacgagaggatgataaactggtggtggaatgcg tcatgaa aggcgtcacttccacgagagtttatgagagagcataagccaagggacgttgacctggact gaagttcgcattgaactctacaa

>384 33_at HG-U95Av2 tgtttcaaggcactctagattccattggtccaagattccggatcctaagcatctaagtta taagactctcacactcagttgtgactaactagacaccaaagttctaataatttctnaatg ttggacacctttnaggttctttgctgcattctgcctctctaggaccatggttaagagtnc caagaatccacatttctaaaatcttatagttctaggcactgtagttctaagactncaaat gttctnaagtttctaagattctaaaggtccacaggtctagactattaggtgcaatttcaa ggttctaaccctatactgtagtattctttggggtgcccctctccttcttagctatcattg cttcctcctccccnaactgtgggggtgtgcccccttcaagcctgtgcaatgcattaggga tgcctcctttcccgcaggggatggacgatctcccacctttcgggccatgttgcccccgtg agccaatccctcaccttctgagtacagagtgtggactc >38438_at HG-U95Av2 aggtgctcagagagccggcccgcctgaatcattctcgatttaactcgagaccttttcaac ttggcttcctttcttggttcataaatgaattttagtttggttnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntngcttactaannnnn nnnnnnnnnnnnnnnnnnnnnnntgctttctgttgtcattgctgttgtccctctgctacg ttcctattgtcattaaaggtatcacggtcgccacctggcattccttctgaccacagcatc attttgcattcaaattaagggttaagaaaagagatattttaaaatgagagtcacttgatg tgccat >38439_at HG-U95Av2 acacttgggatttttctcctctgtcccgaggtcgtcgtctgctttcttttttgggtttct ttctagaagattgagaagtgcatatgacaggctgagagcacctccccaaacacacaagct ctcagecacaggcagcttctccacagnccccagcttcgcacaggctcctggagggctgee tgggggaggcagacatgggagtgccaaggtggccagatggttccaggactacaatgtctt tatttttaactgtttgccactgctgccctcacccctgcccggctctggagtaccgtctgc cccagacaagtgggagtgaa >38453__at HG-U95Av2 cgtggcaatgagactctgcactatgagaccttcgggaaggcnagcccctnctccgcagga nnnnnnnnnnnnnnnnnnacagcacggctgacagagaggatggccaccgcaacttctcct gcctggctgtgctggacttgatgtctcgcggtggcaacatctttcacnaaacactcagcc ccngaagatgttggagatctatg annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnagcggatgggcacctacggggtgcgagcggct tggaggaggctgccccnngnnttccggccatagcaaccatgantngcatggnccnncacc acggtggtcactggaactcagtgtgactcctcagggttgaggtccagccctggctgaagg actgtgacaggcagcagagacttgggacattgccttttctagcccgaatacaaacacctg gaett >3 8 4 54_g_at HG-U95Av2 cactggaactcagtgtgactcctcagggttgaggtccagccctggctgaaggactgtgac aggcagcagagacttgggacattgccttttctagcccgaatacaaacacctgg 103 - 98677.doc 200533758 >38463_s_at HG-U95Av2 tgtcaaagtgactgcgttcatcagttttacactggggctgctacataatattttcatttg aacgaagaacttcaaaaagcacaggactagatgatctctgttccttttggctctaatatg ctacaactgtaggccaattatcactttaccaattaagagttaggccagataagtgaaatt tnnnnnnnnnnnnnnnnnnnnnnnnnnnataggcctaaactggatttccttattccaaat cctgtcttttccccactattccattagacc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna aa a11 tctcccttatcta ctgtgatgacttcagaagatacaatggtcccaggggccaagtagaaagcatt >38466_at HG-U95Av2 tcactgtggccatcaggactttccctgacagctgtgtactcttaggctaagagatgtgac tacagcctgcccctgactgtgttgtcccagggctgatgctgtacaggtacaggctggaga ttttcacataggttagattctcattcacgggactagttagctttaagcaccctagaggac tagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaggtagaaatgtc tatgttttctactccaattcataaatctattcataagtctttggtacaag >38488_s_at HG-U95Av2 tgtgctgtcaaaacaagtttttctgtcaagaagatgatcagaccttggatcagatgaactacacttgggatttttctcctctgtcccgag 38439_at HG-U95Av2; > 384 33_at HG-U95Av2 tgtttcaaggcactctagattccattggtccaagattccggatcctaagcatctaagtta taagactctcacactcagttgtgactaactagacaccaaagttctaataatttctnaatg ttggacacctttnaggttctttgctgcattctgcctctctaggaccatggttaagagtnc caagaatccacatttctaaaatcttatagttctaggcactgtagttctaagactncaaat gttctnaagtttctaagattctaaaggtccacaggtctagactattaggtgcaatttcaa ggttctaaccctatactgtagtattctttggggtgcccctctccttcttagctatcattg cttcctcctccccnaactgtgggggtgtgcccccttcaagcctgtgcaatgcattaggga tgcctcctttcccgcaggggatggacgatctcccacctttcgggccatgttgcccccgtg agccaatccctcaccttctgagtacagagtgtggactc > 38438_at HG-U95Av2 aggtgctcagagagccggcccgcctgaatcattctcgatttaactcgagaccttttcaac ttggcttcctttcttggttcataaatgaattttagtttggttnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntngcttactaannnnn nnnnnnnnnnnnnnnnnnnnnnntgctttctgttgtcattgctgttgtccctctgctacg ttcctattgtcattaaaggtatcacggtcgccacctggcattccttctgaccacagcatc attttgcattcaaattaagggttaagaaaagagatattttaaaatgagagtcacttgatg tgccat & gt gtcgtcgtctgctttcttttttgggtttct ttctagaagattgagaagtgcatatgacaggctgagagcacctccccaaacacacaagct ctcagecacaggcagcttctccacagnccccagcttcgcacaggctcctggagggctgee tgggggaggcagacatgggagtgccaaggtggccagatggttccaggactacaatgtctt tatttttaactgtttgccactgctgccctcacccctgcccggctctggagtaccgtctgc cccagacaagtgggagtgaa > 38453__at HG-U95Av2 cgtggcaatgagactctgcactatgagaccttcgggaaggcnagcccctnctccgcagga nnnnnnnnnnnnnnnnnnacagcacggctgacagagaggatggccaccgcaacttctcct gcctggctgtgctggacttgatgtctcgcggtggcaacatctttcacnaaacactcagcc ccngaagatgttggagatctatg annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnagcggatgggcacctacggggtgcgagcggct tggaggaggctgccccnngnnttccggccatagcaaccatgantngcatggnccnncacc acggtggtcactggaactcagtgtgactcctcagggttgaggtccagccctggctgaagg actgtgacaggcagcagagacttgggacattgccttttctagcccgaatacaaacacctg gaett > 3 8 4 54_g_at HG-U95Av2 cactggaactcagtgtgactcctcagggttgaggtccagccctggctgaaggactgtgac aggcagcagagacttgggacattgccttttctagc ccgaatacaaacacctgg 103 - 98677.doc 200533758 > 38463_s_at HG-U95Av2 tgtcaaagtgactgcgttcatcagttttacactggggctgctacataatattttcatttg aacgaagaacttcaaaaagcacaggactagatgatctctgttccttttggctctaatatg ctacaactgtaggccaattatcactttaccaattaagagttaggccagataagtgaaatt tnnnnnnnnnnnnnnnnnnnnnnnnnnnataggcctaaactggatttccttattccaaat cctgtcttttccccactattccattagacc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna aa a11 tctcccttatcta ctgtgatgacttcagaagatacaatggtcccaggggccaagtagaaagcatt > 38466_at HG-U95Av2 tcactgtggccatcaggactttccctgacagctgtgtactcttaggctaagagatgtgac tacagcctgcccctgactgtgttgtcccagggctgatgctgtacaggtacaggctggaga ttttcacataggttagattctcattcacgggactagttagctttaagcaccctagaggac tagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaggtagaaatgtc tatgttttctactccaattcataaatctattcataagtctttggtacaag > 38488_s_at HG-U95Av2 tgtgctgtcaaaacaagtttttctgtcaagaagatgatcagaccttggatcagatgaact

cttagaaatgaaggcagaaaaatgtcattgagtaatatagtgactatgaacttctctcag acttactttactcatttttttaatttattattgaaattgtacatatttgtggaataatgt aaaatgttgaataaaaatatgtacaagtgttgttttttaagttgcactgatattttacct cttattgcaaaatagcatttgtttaagggtgatagtcaaattatgtattggtggggctgg gtaccaatgctgcaggtca >384_at HG-U95AV2 acgccgagatgaccacacggatggtggcgtccaagatggagctacacgcgttatctacgg gccgcgagccccgcgtggccacggtcactcgcatcctgcgccagacgctcttcaggtacc agggccacgtgggtgcatcgctgatcgtgggcggcgtagacctgactggaccgcagctct acggtgtgcatccccatggctcctacagccgtctgcccttcacagccctgggctctggtc aggacgcggccctggcggtgctagaagaccggttccagccgaacatgacgctggaggctg ctcaggggctgctggtggaagccgtcaccgccgggatcttgggtgacctgggctccgggg gcaatgtggacgcatgtgtgatcacaaagactggcgccaagctgctgcggacactgagct cacccacagagcccgtgaagaggtctggccgctaccactttgtgcctggaaccacagctg tcctgacccagacagtgaagccact >38584_at HG-U95Av2 tattttcctgtcagcatctgagcttgaggatggtagtgagnaaatgggccagggcgcagt cagctccagtcccagagagctcctctctaactcagagcaactgaactgagacagaggagg aaaacagagcatcagaagcctgcagtggtggttgtgacgggtaggaggataggaagacag ggggccccaacctgggattgctgagcagggaagctttgcatgttgctctaaggtacattt tt >38617_at HG-U95Av2 gagatagetccctgagetgggccatctgacttctacctcccatgtttgctctcccaactc attagctcctgggcagcatcctcctgagccacatgtncnggnnnngnaaancctnnnnnn nnnnnnnnnnnnnnnnnnnnactcttcatcacaactagatttgcctcttctaagtgtcta tgagcttgcaccatatttaataaattgggaatgggtttggggtattaatgcaatgtgtgg tggttgtattggagcagggggaattgataaaggagagtggttgctgttaatattatctta tctattgggtggtatgtgaaatattgtacatagacctgatgagttgtgggaccagatgtc atctctggtcagagtttacttgctatatagactgtacttatgtgtgaagtttgcaagctt getttnaggnetgagecctggactcccageagcagcacagttcagcattgtgtggctggt tg >38631_at HG-U95Av2 gctctaccccaggaaaatgtgagctcgttttcctgctcggcatgtgctccccctaaggct ctgctccnnnnnnnnnnnnnnnngttccttctcagcctgagagggggcccttcgnnctca ggcatgactcagcccnnnnnnnnnnnnnnnngnnnnnnnnnnnnnnnnnnnnnnnnnnnn cttgggtcngtccccttttcccaggtactgccttacaaagctgtggccaggaagtggccg gtataaaggatgcccaaggtctttgtacgtgtgtaggagttagcgtgtttgatattgtta atataataataattattttttagagtactgcttttgtatgtatgttgaacaggatccagg 104- 98677.doc 200533758 tttttatagct >38787_at HG-U95AV2 tgccgaaaactcgtcctcccgagagctggatgacagcagcagtgagtccagtgacctcca gctggaaggccccagcaccctcagggtcctggacgagaaccttgctgacccccaagcaga agacagacctctggttttctttgacctcaagattgacaatgaaagtgggttctcctgggg ctacccccacccctttctaatttagtctctgagtcccaaaaag >38880_at HG-U95Av2 gcacccacgggtgtgctggatactggagtttgagaggagggaggtgctggggccaaagga gacactanaaaagtggtagatgggacaggtaagtggcagaggtgaggggntaagttanaa tgtanaagggcagtaattaggggtgagggaaaggagataggggaccctaggaggtagagt gggnccatgtcgtgaggcagttgaagagttgaggaaaggttttnctgggccctactgctc ccctctgctgcaggtaagtcagagcagctttaccacagcttcaggccacgagag >38916_at HG-U95Av2 gaacctttcagtctccgctagctctttcctnnnnnnnnnnnnnnnnnnnnnngttttatc gttaagtgccccacagagacactttaccaggaggctgggagagttctccagatttgggagcttagaaatgaaggcagaaaaatgtcattgagtaatatagtgactatgaacttctctcag acttactttactcatttttttaatttattattgaaattgtacatatttgtggaataatgt aaaatgttgaataaaaatatgtacaagtgttgttttttaagttgcactgatattttacct cttattgcaaaatagcatttgtttaagggtgatagtcaaattatgtattggtggggctgg gtaccaatgctgcaggtca > 384_at HG-U95AV2 acgccgagatgaccacacggatggtggcgtccaagatggagctacacgcgttatctacgg gccgcgagccccgcgtggccacggtcactcgcatcctgcgccagacgctcttcaggtacc agggccacgtgggtgcatcgctgatcgtgggcggcgtagacctgactggaccgcagctct acggtgtgcatccccatggctcctacagccgtctgcccttcacagccctgggctctggtc aggacgcggccctggcggtgctagaagaccggttccagccgaacatgacgctggaggctg ctcaggggctgctggtggaagccgtcaccgccgggatcttgggtgacctgggctccgggg gcaatgtggacgcatgtgtgatcacaaagactggcgccaagctgctgcggacactgagct cacccacagagcccgtgaagaggtctggccgctaccactttgtgcctggaaccacagctg tcctgacccagacagtgaagccact > 38584_at HG-U95Av2 tattttcctgtcagcatctgagcttgaggatggtagtgagnaaatgggccagggcgcagt cagctccagtcccagagagctcctctctaactcagagcaactgaactgagacagaggagg aaaacagagcatcagaagcctgcagtggtggttgtgacgggtaggaggataggaag acag ggggccccaacctgggattgctgagcagggaagctttgcatgttgctctaaggtacattt tt > ttt 38631_at HG-U95Av2 gctctaccccaggaaaatgtgagctcgttttcctgctcggcatgtgctccccctaaggct ctgctccnnnnnnnnnnnnnnnngttccttctcagcctgagagggggcccttcgnnctca ggcatgactcagcccnnnnnnnnnnnnnnnngnnnnnnnnnnnnnnnnnnnnnnnnnnnn cttgggtcngtccccttttcccaggtactgccttacaaagctgtggccaggaagtggccg gtataaaggatgcccaaggtctttgtacgtgtgtaggagttagcgtgtttgatattgtta atataataataattattttttagagtactgcttttgtatgtatgttgaacaggatccagg 104- 98677.doc 200533758; 38617_at HG-U95Av2 gagatagetccctgagetgggccatctgacttctacctcccatgtttgctctcccaactc attagctcctgggcagcatcctcctgagccacatgtncnggnnnngnaaancctnnnnnn nnnnnnnnnnnnnnnnnnnnactcttcatcacaactagatttgcctcttctaagtgtcta tgagcttgcaccatatttaataaattgggaatgggtttggggtattaatgcaatgtgtgg tggttgtattggagcagggggaattgataaaggagagtggttgctgttaatattatctta tctattgggtggtatgtgaaatattgtacatagacctgatgagttgtgggaccagatgtc atctctggtcagagtttacttgctatatagactgtacttatgtgtgaagtttgcaagctt getttnaggnetgagecctggactcccageagcagcacagttcagcattgtgtggctggt tg & gt ttatagct > 38787_at HG-U95AV2 tgccgaaaactcgtcctcccgagagctggatgacagcagcagtgagtccagtgacctcca gctggaaggccccagcaccctcagggtcctggacgagaaccttgctgacccccaagcaga agacagacctctggttttctttgacctcaagattgacaatgaaagtgggttctcctgggg ctacccccacccctttctaatttagtctctgagtcccaaaaag > 38880_at HG-U95Av2 gcacccacgggtgtgctggatactggagtttgagaggagggaggtgctggggccaaagga gacactanaaaagtggtagatgggacaggtaagtggcagaggtgaggggntaagttanaa tgtanaagggcagtaattaggggtgagggaaaggagataggggaccctaggaggtagagt gggnccatgtcgtgaggcagttgaagagttgaggaaaggttttnctgggccctactgctc ccctctgctgcaggtaagtcagagcagctttaccacagcttcaggccacgagag > 38916_at HG-U95Av2 gaacctttcagtctccgctagctctttcctnnnnnnnnnnnnnnnnnnnnnngttttatc gttaagtgccccacagagacactttaccaggaggctgggagagttctccagatttgggag

aggcgcagagacagtgtgtgagccgagccctgtctcagcaatccacctggaggagctaga gtatcctcctccctttaccattcagaccgagagaaaaagcccagcttgtgtgcaccctcg tggggttaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntttgttttgatgtaaggc tctgtggtttgggggggaacatctgtaaacattattagttgatttggggtttgtctttga tggtttctatctgcaattatcgtcatgtatatttaagtgtctgttatagaaaacccacac ccactgtcctgtaaacttttctcagtgtnnnnnnnnnnnnnnntcacattttaattgcca cctcgtatttcacctctacatttgaaatctggcgtctgtttcaagccagtgtgtt >38944一at HG-U95Av2 ctctcagaacatactgattgggaggtgcgtgttcagcagaacctgcacacaggacagcgg gaaaaatcgatgagcgccacctctttaaaaactcacttacgtttgtcctttttcactttg aaaagttggaaggatctgctgaggcccagtgcatatgcaatgtatagtgtctattatcac attaatctcaaagagattcgaatgacggtaagtgttctcatgaagcaggaggcccttgtc gtgggatggcatttggtctcaggcagcaccacactgggtgcgtctccagtcatctgtaag agcttgctccagattctgatgcatacgg >38970_s_at HG-U95Av2 accatccgttgcagaagcctccaggagcagcaatcctaagagtgggaggcagccnaagac ccccttccttcaaaanncntcccggaagtggtttcaggccctctagttgccatgaccaat ttgtgtgtgtgtttaatttttgcttcaagctctgtagcaggacctgccccacgcacaccc c-tacccctctgtgaggagctgtgggaagtgtgggtttgtctccagaacagaagagaatga tggatattctggctctggggccctctccaccaccactcacagtagccttgctgaagccat cacagatgggagaaggccatgccagccacgtccgccgaggggcgccagcctgaagctgcc aggccctgaggttcagaccctggaccccatagctggaggcctgtggtgccagaagcccag attagggtggctgtccatccctggatagctatttgcacgaatcatggacataa >38971_r_at HG-U95AV2 gcaatcctaagagtgggaggcagccnaagacccccttccttcaaaanncntcccggaagt ggtttcaggccctctagttgccatgaccaatttgtgtgtgtgtttaatttttgcttcaag ctctgtagcaggacctgccccacgcacacccctacccctctgtgaggagctgtgggaagt gtgggtttgtctccagaacagaagagaatgatggatattctggctctggggccctctcca ccaccactcacagtagccttgctga >39032_at HG-U95Av2 atgacacaaaactatgagagtgacaaaatggtgannnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntgtagtgtaactattttg tancaatagaggactgtaactactatttaggttgtacagattgaaatttagttgtttcat tggctgtctgaggaggtgtggacttttatatatagatctacataaaaactgctacatgac aaaaaccacacctaaagaaattttaangannnnnnnnnnnnnnnnnntcactttngtngt aatctngaaatcntnnnnnnnnnnnnnnnnnnnnnnnnaatccttgttcactgaagtctt tcaattgagctggttgaatactttgaaaaatgctcagttctaactaatgaaatggatttc ccagtagggnnnnnnnnnnnnnnnntgtatagtagttatatgcatatgtttctgtgcatg ttctctacacaattgtaaggtgtcactgtatttaactgttgcacttg 105- 98677.doc 200533758 >39070_at HG-U95AV2 ggggccgtcttcctcctgtctctttcctttcaccctagcctgactggaagcagaaaatga ccaaatcagtattttttttaatgaaatattattgctggaggcgtcccaggcaagcctggc tgtagtagcgagtgatctggcggggggcgtctcagcaccctccccagggggtgcatctca gccccctctttccgtccttcccgtccagccccagccctgggcctgggctgccgacacctg ggccagagcccctgctgtgattggtgctccctgggcctcccgggtggatgaagccaggcg tcgccccctccgggagccctggggtgagccgccggggcccccctgctgccagcctccccc gtccccaacatgcatctcactctgggtgtcttggtcttttattttttgtaagtgtcattt gtataactctaaacgcccatgatagtagcttcaaactggaaatagcgaa >39071_at HG-U95Av2 actcagtgttttggagagtattccttttagtttgttggttggctggtttgaacgatagna aatatgcagcatgcaatatatgcttatatttcattttaatttctgatatataatgaactt cttgggagaggtactgaatctttgatgttttttgtcattgttctcaagtgcaatataaca atgtaaccaaatctagataatttcaaagttgtcattaatttagtaagcctaatataaaca aatatttgtattatttttnnnnnnnnnnnnnnnnnnttaagtgaggttatttacccctaa atggtccattctgcattgtatttcaggctggaaatgaattattctttaccagttttgaaaaggcgcagagacagtgtgtgagccgagccctgtctcagcaatccacctggaggagctaga gtatcctcctccctttaccattcagaccgagagaaaaagcccagcttgtgtgcaccctcg tggggttaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntttgttttgatgtaaggc tctgtggtttgggggggaacatctgtaaacattattagttgatttggggtttgtctttga tggtttctatctgcaattatcgtcatgtatatttaagtgtctgttatagaaaacccacac ccactgtcctgtaaacttttctcagtgtnnnnnnnnnnnnnnntcacattttaattgcca cctcgtatttcacctctacatttgaaatctggcgtctgtttcaagccagtgtgtt > 38944 a at HG-U95Av2 ctctcagaacatactgattgggaggtgcgtgttcagcagaacctgcacacaggacagcgg gaaaaatcgatgagcgccacctctttaaaaactcacttacgtttgtcctttttcactttg aaaagttggaaggatctgctgaggcccagtgcatatgcaatgtatagtgtctattatcac attaatctcaaagagattcgaatgacggtaagtgttctcatgaagcaggaggcccttgtc gtgggatggcatttggtctcaggcagcaccacactgggtgcgtctccagtcatctgtaag agcttgctccagattctgatgcatacgg > 38970_s_at HG-U95Av2 accatccgttgcagaagcctccaggagcagcaatcctaagagtgggaggcagccnaagac ccccttccttcaaaanncntcccggaagtggtttcaggccctctagttgccatgaccaat ttgtgtgtgtgtttaatttttgcttcaagctctgtagcaggacctgccccacgcacaccc c-tacccctct gtgaggagctgtgggaagtgtgggtttgtctccagaacagaagagaatga tggatattctggctctggggccctctccaccaccactcacagtagccttgctgaagccat cacagatgggagaaggccatgccagccacgtccgccgaggggcgccagcctgaagctgcc aggccctgaggttcagaccctggaccccatagctggaggcctgtggtgccagaagcccag attagggtggctgtccatccctggatagctatttgcacgaatcatggacataa > 38971_r_at HG-U95AV2 gcaatcctaagagtgggaggcagccnaagacccccttccttcaaaanncntcccggaagt ggtttcaggccctctagttgccatgaccaatttgtgtgtgtgtttaatttttgcttcaag ctctgtagcaggacctgccccacgcacacccctacccctctgtgaggagctgtgggaagt gtgggtttgtctccagaacagaagagaatgatggatattctggctctggggccctctcca ccaccactcacagtagccttgctga > 39032_at HG-U95Av2 atgacacaaaactatgagagtgacaaaatggtgannnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntgtagtgtaactattttg tancaatagaggactgtaactactatttaggttgtacagattgaaatttagttgtttcat tggctgtctgaggaggtgtggacttttatatatagatctacataaaaactgctacatgac aaaaaccacacctaaagaaattttaangannnnnnnnnnnnnnnnnntcactttngtngt aatctngaaatcntnnnnnnnnnnnnnnnnnnnnnnnnaatccttgttcactgaagtctt tcaattgagctggttgaatactttgaaa aatgctcagttctaactaatgaaatggatttc ccagtagggnnnnnnnnnnnnnnnntgtatagtagttatatgcatatgtttctgtgcatg ttctctacacaattgtaaggtgtcactgtatttaactgttgcacttg 105- 98677.doc 200533758 > 39070_at HG-U95AV2 ggggccgtcttcctcctgtctctttcctttcaccctagcctgactggaagcagaaaatga ccaaatcagtattttttttaatgaaatattattgctggaggcgtcccaggcaagcctggc tgtagtagcgagtgatctggcggggggcgtctcagcaccctccccagggggtgcatctca gccccctctttccgtccttcccgtccagccccagccctgggcctgggctgccgacacctg ggccagagcccctgctgtgattggtgctccctgggcctcccgggtggatgaagccaggcg tcgccccctccgggagccctggggtgagccgccggggcccccctgctgccagcctccccc gtccccaacatgcatctcactctgggtgtcttggtcttttattttttgtaagtgtcattt gtataactctaaacgcccatgatagtagcttcaaactggaaatagcgaa > 39071_at HG-U95Av2 actcagtgttttggagagtattccttttagtttgttggttggctggtttgaacgatagna aatatgcagcatgcaatatatgcttatatttcattttaatttctgatatataatgaactt cttgggagaggtactgaatctttgatgttttttgtcattgttctcaagtgcaatataaca atgtaaccaaatctagataatttcaaagttgtcattaatttagtaagcctaatataaaca aatatttgtattatttttnnnnnnnnnnnnnnnnnnttaagtgaggttatttacccctaa atggt ccattctgcattgtatttcaggctggaaatgaattattctttaccagttttgaaa

cactttgaaatatcctaaggtaacttggaagctgtgtagtatatcaaattaatttgctac ctaataacatagaaagtaaatatctttgtggtcacccacattgggtgagacagaaaat >39081_at HG-U95Av2 gtgatccttatcagggagagcaggaatccttattcccggtgtcgctagtactcatctctg ccgcctcctgtctgccccc a gnnnnnnnnnnnnnnnnnnnc nncgaacccg c gnnnnanc ntgtcccgactctagccgcctnttcagcnnnncnnngnnnccnannnnnncnnnnncnnc ngnnnnnncnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaatgcacctcctg caagaaaagctgctgctcctgctgccctgtgggctgtgccaagtgtgcccagggctgcat ctgcaaaggggcgtcggacaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnccccgctcc cagatgtaaagaacgcgacttccacaaacctggatttt >39107_at HG-U95AV2 acttcagtgtcagtatccctgccttcagtcttctttagaaatcacatctgtgttcaatcc attgtttag.agggagtgtatttttcctgttccnnnnnnnnnnnnnnnngttcacaattgg atcacaatgcagaggagtctgttcctcccccgtcggcttctcggtgctgggagggtgacc tgtcccagatgactcatcaccctgacatgctcttgacaaaggacaccaccaagaggagat ggcagctgtaccggtgcagcctctgtctgagggggatatttgcctcagtgtgattaaaaa tcagtcatgaaagatttttgaattcagattatttttatcaggaacagattttgaacatcc tgaaatcttttccctggcatcatattaggttttctttgttcactatgatgtaaagtttca gactcttgatatttttaatatcaacatagacggtaggacaaggaacggtaccagaaatga gtaaagagacaataatgataagatcgatttatcaagacataacaaccccaaatgtatatg cactaaataacagcttcaaaatacatgaagcaaaatgg >39119_s_at HG-U95Av2 gtcccggatgttgaggatcccgcaanccgaggagcctggggagagcttttntnacaaggt catgagannnnnnnnnnnnnnnnncntgcagcggctgcagacctggtggcacggggttct ggcctgggtgaaggagaaggtggtggccctggtccatgcagtgcaggccctctggaaaca gttccagagtttctgctgctetctgtcagagctctteatgtcctctttccagtcctacgg agncccacggggggacaaggaggagctgacaccccagaagtgctctgaaccccaatcctc aaaatgaagatactgacaccacctttgc >39120_at HG-U95AV2 tgtcccgctgcgtgttttcctcttgatcngggaactcctgcttctccttgcctcgaaatg gaccccaactgctcctgctcgcctgttggctcctnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnaaatgcacctcctgcaagaagagctgctgctcctgctgccctgtgggctgt gccaagtgtgcccagggctgcatctgcaaagggacgtcagacaagtgcagctgctgtgcc tgatgccaggacagctgtgctctcagatgtaaatagagcaacctatataaacctgga >39253_s_at HG-U95Av2 aagcagacagctatcggaagaaggtagtgctagatggggaggaagtccagatcgatatct tagatacagctgggcaggaggactacgctgcaattagagacaactacttccgaagtgggg aggggttcctctgtgttttctctattacagaaatggaatcctttgcagctacagctgact 106- 98677.doc 200533758 tcagggagcagattttaagagtaaaagaagatgagaatgttccatttctactggttggta acaaatcagatttagaagataaaagacaggtttctgtagaagaggcaaaaaacagagctg agcagtggaatgttaactacgtggaaacatctgctaaaacacgagctaatgt >39267_at HG-U95Av2 tgcacatgaagtgagcttggcagtatttcagctggctggaggaattggagaaaggcccca accaggtttctgaannnnnnnnnnnnnnnnnnnagaaactggactttttacaagtcttta caaaactgtcaataataatggcagtactaagagatttataatcataatgtttacaatgca gcctactggattgtctctagatetgtttttcttaaacactaacagaataattctttataa ataggtaagccttacacttgttaaagaaatttacctctaatttcagtctcactaatgtaa aatactgggacttaagtatacaattcagtcactaactgtacagttttatgtggggaacaa ttcatgcaggctactggaaaattaaatcttattaccaannnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnncaagatgatgttttgcagcattcnnnnnnnnnnnnnnnaatggaga gggcagagaagactttatacaaccagtttttccattgcagagtcttaagaaagattatta gatgacttacctatatggactaatgccatccaggaactcagaggtatg >39300_at HG-U95AV2 gaggcaggaatctccatttttgtgctttttgaaaatgcaatgaattcctatacgggggag cgggaaaggtgcctcagagagagacaagtctggatgagggaaatattgaatattctcaatcactttgaaatatcctaaggtaacttggaagctgtgtagtatatcaaattaatttgctac ctaataacatagaaagtaaatatctttgtggtcacccacattgggtgagacagaaaat > 39081_at HG-U95Av2 gtgatccttatcagggagagcaggaatccttattcccggtgtcgctagtactcatctctg ccgcctcctgtctgccccc a gnnnnnnnnnnnnnnnnnnnc nncgaacccg c gnnnnanc ntgtcccgactctagccgcctnttcagcnnnncnnngnnnccnannnnnncnnnnncnnc ngnnnnnncnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaatgcacctcctg caagaaaagctgctgctcctgctgccctgtgggctgtgccaagtgtgcccagggctgcat ctgcaaaggggcgtcggacaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnccccgctcc cagatgtaaagaacgcgacttccacaaacctggatttt > 39107_at HG-U95AV2 acttcagtgtcagtatccctgccttcagtcttctttagaaatcacatctgtgttcaatcc attgtttag.agggagtgtatttttcctgttccnnnnnnnnnnnnnnnngttcacaattgg atcacaatgcagaggagtctgttcctcccccgtcggcttctcggtgctgggagggtgacc tgtcccagatgactcatcaccctgacatgctcttgacaaaggacaccaccaagaggagat ggcagctgtaccggtgcagcctctgtctgagggggatatttgcctcagtgtgattaaaaa tcagtcatgaaagatttttgaattcagattatttttatcaggaacagattttgaacatcc tgaaatcttttccctggcatcatattaggttttctttgttcactatgatgtaaagtt tca gactcttgatatttttaatatcaacatagacggtaggacaaggaacggtaccagaaatga gtaaagagacaataatgataagatcgatttatcaagacataacaaccccaaatgtatatg cactaaataacagcttcaaaatacatgaagcaaaatgg > 39119_s_at HG-U95Av2 gtcccggatgttgaggatcccgcaanccgaggagcctggggagagcttttntnacaaggt catgagannnnnnnnnnnnnnnnncntgcagcggctgcagacctggtggcacggggttct ggcctgggtgaaggagaaggtggtggccctggtccatgcagtgcaggccctctggaaaca gttccagagtttctgctgctetctgtcagagctctteatgtcctctttccagtcctacgg agncccacggggggacaaggaggagctgacaccccagaagtgctctgaaccccaatcctc aaaatgaagatactgacaccacctttgc > 39120_at HG-U95AV2 tgtcccgctgcgtgttttcctcttgatcngggaactcctgcttctccttgcctcgaaatg gaccccaactgctcctgctcgcctgttggctcctnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnaaatgcacctcctgcaagaagagctgctgctcctgctgccctgtgggctgt gccaagtgtgcccagggctgcatctgcaaagggacgtcagacaagtgcagctgctgtgcc tgatgccaggacagctgtgctctcagatgtaaatagagcaacctatataaacctgga > 39253_s_at HG-U95Av2 aagcagacagctatcggaagaaggtagtgctagatggggaggaagtccagatcgatatct tagatacagctgggcaggaggactacgctgcaattagagacaactacttccgaagtgggg aggg gttcctctgtgttttctctattacagaaatggaatcctttgcagctacagctgact 106- 98677.doc 200533758 tcagggagcagattttaagagtaaaagaagatgagaatgttccatttctactggttggta acaaatcagatttagaagataaaagacaggtttctgtagaagaggcaaaaaacagagctg agcagtggaatgttaactacgtggaaacatctgctaaaacacgagctaatgt > 39267_at HG-U95Av2 tgcacatgaagtgagcttggcagtatttcagctggctggaggaattggagaaaggcccca accaggtttctgaannnnnnnnnnnnnnnnnnnagaaactggactttttacaagtcttta caaaactgtcaataataatggcagtactaagagatttataatcataatgtttacaatgca gcctactggattgtctctagatetgtttttcttaaacactaacagaataattctttataa ataggtaagccttacacttgttaaagaaatttacctctaatttcagtctcactaatgtaa aatactgggacttaagtatacaattcagtcactaactgtacagttttatgtggggaacaa ttcatgcaggctactggaaaattaaatcttattaccaannnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnncaagatgatgttttgcagcattcnnnnnnnnnnnnnnnaatggaga gggcagagaagactttatacaaccagtttttccattgcagagtcttaagaaagattatta gatgacttacctatatggactaatgccatccaggaactcagaggtatg > 39300_at HG-U95AV2 gaggcaggaatctccatttttgtgctttttgaaaatgcaatgaattcctatacgggggag cgggaaaggtgcctcagagagagacaagtctggatgag ggaaatattgaatattctcaat

caaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngacttgaaagacctgag tccattacgttgagaagggacctgctgattgctttgattccccctggcaagtgctccctg gttgtgaatgccaggcactagagatggtgaggggttggggggcagttgggcacacacagt gtaagagcaattcagagccgttagtcctgcactagccctcaagctgctggcaacacctag agaaggtcgaagggccctgccagagatccc >39310_at HG-U95Av2 gcaaagagcccataaatcctgaccaatccaactctgaattttaanncaaaagcgtnaaaa aaaagattccctccttacccccaacccactcttttttcccaccacccactctcctctgcc tcagtaagtatctggaggaagaaaacaggtgaaagaagaagtaaaaaccatttagtatta gtattagaatgaagtcaaactgtgccacacatggtgaatgnnaaaaaaaaaaaagaggct gtgttttgtcacacagggcagtcattcagcaccagagcacgtgatggtctgagactctct taggagcagagnnnnnnnnnnnnnnnnnngtgggnnnnnnnnnnnnnnnnnnggggcaac tgagtctgcgggagaagagcggccctatgcatggtgta >39327_at HG-U95Av2 ggttccatcacaagctatgtttaaaaagaaaattggtgtttggcaaacggaacagaacct ttgatgagagcgnttcacagggacactgtctgggggtgcagtgcaagcccccggcctctt ccctgggaacctctgaactcctccttcctctgggctctctgtaacatttcaccacacgtc agcatctaatcccaagacaaacattcccncntgctcgaagcagctgtatagcctgtgact ctccgtgtgtcagctccttccacacctgattagaacattcataagccacatttagaaaca gntttnntttcagctgtcacttgcacacatactgcctagttgtgaaccaaatgtgaaaaa acctccttcatcccattgtgtatctgatacctnccgagggccaagggtgtgtgttgacaa cgccgcteecagecggccctggttgcgtccacgtcctgaacaagagccgcttccggatgg ctcttcccaagggaggaggagctcaagtgtcgggaactgtctaacttcaggttgtgtgag tgcgt >39333_at HG-U95Av2 gaatgacttgacttcaaaagcaacaaccttaaaggccgtcatttcattagtattcctcat tctgcatcctggcttgaaaaacagctctgttgaatcacagtatcagtattttcacacgta agcacattcgggccatttccgtggtttctcatgagctgtgttcacagacctcagcagggc atcgcatggaccgcaggagggcagattcggaccactaggcctgaaatgacatttcactaa aagtctccaaaacatttctaagannnnnnnnnnnnnnnatgtaatttctttaaatgtgta tttcttaagaattcaaatttgtaataaaactatttgtataaaaannaagcttttattaat ttgttgctagtattgccacagacgcattaaaagaaacttactgcacaagctgctaat >39397_at HG-U95AV2 atttttaggtgaagtcgagcactctaattagagaactggaggaaccacatataacactta acttcccctaccctgcccctccccaaaagaaaccatgacaaacctagcttttaaaaaata ttttaagaaagagaatgaact nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnngtgaacttttgtaatttgaattgggtcccgcttagttc ttgaattgttatgaaaatcctatatctgtttgtatatttgcaaaccctttgtattataat 107- 98677.doc 200533758 tgttgatattttccctttttaaaaaataccattgaaatcagcatgacaaaaataacactg ttggcacttataggtaacgtga >393_s—at HG-U95Av2 atacctgtttctttgggacattccgtcctgatgattttttattggttggtttttattttt ggggggaatgacatgtttgggtcttttatacatgaaaatttgtttgacaataatctcaca caacatattttacatctgagcacaatgcctttttgtttaccgtagcgtatacatttgttt tgggatttttgtgtgtttgttgggaattttgtttttagccaggtcagtattgat >39402一at HG-U95Av2 aatgtggactcaatccctagggctggcagaaagggaacagaaaggtttttnagtacggct atagcctggactttcctgttgtctacaccaatgcccaactgcctgccttagggtagtgct aannnnnnnnnnnnnnnnncagccaggacagtcagctctctcctttcagggccaatcccc agcccttttgttgagccaggcctctctcacctctcctactcacttaaagcccgcctgaca gaaaccacggccacatttggttctaagaaacnnncctctgtcattcgctcccacattctg nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnaagggggcaagaagtagcagtgtctgtaaaagagcctagtttttaatagct atggaatcaattcaatttggactggtgtgctctctttaaatcaagtcctttaattaagac tgaaaatatataagctcagattatttaaatgggaatatttataaatgagcaaatatcatacaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngacttgaaagacctgag tccattacgttgagaagggacctgctgattgctttgattccccctggcaagtgctccctg gttgtgaatgccaggcactagagatggtgaggggttggggggcagttgggcacacacagt gtaagagcaattcagagccgttagtcctgcactagccctcaagctgctggcaacacctag agaaggtcgaagggccctgccagagatccc > 39310_at HG-U95Av2 gcaaagagcccataaatcctgaccaatccaactctgaattttaanncaaaagcgtnaaaa aaaagattccctccttacccccaacccactcttttttcccaccacccactctcctctgcc tcagtaagtatctggaggaagaaaacaggtgaaagaagaagtaaaaaccatttagtatta gtattagaatgaagtcaaactgtgccacacatggtgaatgnnaaaaaaaaaaaagaggct gtgttttgtcacacagggcagtcattcagcaccagagcacgtgatggtctgagactctct taggagcagagnnnnnnnnnnnnnnnnnngtgggnnnnnnnnnnnnnnnnnnggggcaac tgagtctgcgggagaagagcggccctatgcatggtgta > 39327_at HG-U95Av2 ggttccatcacaagctatgtttaaaaagaaaattggtgtttggcaaacggaacagaacct ttgatgagagcgnttcacagggacactgtctgggggtgcagtgcaagcccccggcctctt ccctgggaacctctgaactcctccttcctctgggctctctgtaacatttcaccacacgtc agcatctaatcccaagacaaacattcccncntgctcgaagcagctgtatagcctgtgact ctccgtgtgtcagctccttccacacctgat tagaacattcataagccacatttagaaaca gntttnntttcagctgtcacttgcacacatactgcctagttgtgaaccaaatgtgaaaaa acctccttcatcccattgtgtatctgatacctnccgagggccaagggtgtgtgttgacaa cgccgcteecagecggccctggttgcgtccacgtcctgaacaagagccgcttccggatgg ctcttcccaagggaggaggagctcaagtgtcgggaactgtctaacttcaggttgtgtgag tgcgt > 39333_at HG-U95Av2 gaatgacttgacttcaaaagcaacaaccttaaaggccgtcatttcattagtattcctcat tctgcatcctggcttgaaaaacagctctgttgaatcacagtatcagtattttcacacgta agcacattcgggccatttccgtggtttctcatgagctgtgttcacagacctcagcagggc atcgcatggaccgcaggagggcagattcggaccactaggcctgaaatgacatttcactaa aagtctccaaaacatttctaagannnnnnnnnnnnnnnatgtaatttctttaaatgtgta tttcttaagaattcaaatttgtaataaaactatttgtataaaaannaagcttttattaat ttgttgctagtattgccacagacgcattaaaagaaacttactgcacaagctgctaat > 39397_at HG-U95AV2 atttttaggtgaagtcgagcactctaattagagaactggaggaaccacatataacactta acttcccctaccctgcccctccccaaaagaaaccatgacaaacctagcttttaaaaaata ttttaagaaagagaatgaact nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnngtgaacttttgtaatttgaattgggtcccgcttagttc ttga attgttatgaaaatcctatatctgtttgtatatttgcaaaccctttgtattataat 107- 98677.doc 200533758 tgttgatattttccctttttaaaaaataccattgaaatcagcatgacaaaaataacactg ttggcacttataggtaacgtga > 393_s-at HG-U95Av2 atacctgtttctttgggacattccgtcctgatgattttttattggttggtttttattttt ggggggaatgacatgtttgggtcttttatacatgaaaatttgtttgacaataatctcaca caacatattttacatctgagcacaatgcctttttgtttaccgtagcgtatacatttgttt tgggatttttgtgtgtttgttgggaattttgtttttagccaggtcagtattgat > 39402 a at HG-U95Av2 aatgtggactcaatccctagggctggcagaaagggaacagaaaggtttttnagtacggct atagcctggactttcctgttgtctacaccaatgcccaactgcctgccttagggtagtgct aannnnnnnnnnnnnnnnncagccaggacagtcagctctctcctttcagggccaatcccc agcccttttgttgagccaggcctctctcacctctcctactcacttaaagcccgcctgaca gaaaccacggccacatttggttctaagaaacnnncctctgtcattcgctcccacattctg nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnaagggggcaagaagtagcagtgtctgtaaaagagcctagtttttaatagct atggaatcaattcaatttggactggtgtgctctctttaaatcaagtcctttaattaagac tgaaaatatataagctcagattatttaaatgggaatatttataaatgagcaaatatca ta

ctgttcaatg >39409_at HG-U95Av2 ctggacacccatctctaaagcaggacgcctgccagggggatagtgggggcgtttttgcag taagggacccgaacactgatcgctgggtggccacgggcatcgtgtcctggggcatcgggt gcagcaggggctatggcttctacaccaaagtgctcaactacgtggactggatcaagaaag agatggaggaggaggactgagcccagaattcactaggttcgaatccagagagcagtgtgg a a a a a a a a a a a c a a a a a a c a a mmrmmmrmrmnrmrmmmnmma g a g t c t c t mma a a antnnnnnnnnanannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttgatgtact ttacctgaaacaacccaaagggcccctttctttcttctgaggattgcagaggatatagtt atcaatctctagttgtcactttcctcttccactttgataccattgggtcattgaatataa c >39421_at HG-U95AV2 gacggtataacacatctactgaaaaagcaannnnnnnnnnnnnnnnatttaagccagccc ccacctagggtctatttgtgtggcagttattgggtttggtcacaaaacatcctgaaaatt cgtgcgtgggcttctttctccctggtacaaacgtatggaatgcttcttaaaggggaactg tcaagctggtgtcttcagccagatgacatgagagaatatcccagaaccctctctccaagg tgtttctagatagcacaggagannnnnnnnnnnnnnntccacagtccacggtacacagtc gggtgggccgcctcccctctcctgggagcattcgtcgtgcccagcctgagcagggcagct ggactgctgctgttcaggagccaccagagccttcctctctttgtaccacag >39517_at HG-U95Av2 tcttaggggtcattatcacttaaataatactgtacctaggtctttcaaattaaaattata cctgaatgaagttgtttgtatacataaaggatatttgtgtacaattaccttttttccccc acacttgttttctttgtttttgttnnnnnnnnnnnnnnnnnnnnnnntnnactatgggat tcatttatgtctgtctttctatcataaagaattgatcaatatgtaaatatgtgatttgaa ccatggttgacttacaagtgtcactacagctttttagaaaacatagccctaatatatgtt aagcaggacccgggtgagccagtggnnttgcgctttatgtagagctggaagaaggccgtc catcctgtctcttgggcggacagtgtactttcctaatagggaagggaagcacaatggaaa tacccctgaaccg >39532_at HG-U95Av2 attgccaccctgaaccagctctgtgccaccaagttccgagnnnnnnnnnnnnnnnnnnnn nncctcttcctgtacaaggagnnnggctaccnccgcctgccccctgggnccntggccnac aggctgcccaccactggctacctcgtctaccgccgggcagagtggcctgagacccagggg gctgtgacagaggaggagggcagtgggcagtcagaggcaagaagcagaggggaggagcaa gggtgccagggagatggggatgctggggtcaaagccagccccagggacattcgggaacag tctgagacaactgctgaagggggccagggtcaagcccaggaaggccctgctcagccaggg gaaccagaggcagagggaagccgggcagcagaggagnnnnnnnnnnnnnnnagaagggtc attcggggcgggagaccctgagcctgctgagaaatccttttagcgccagcaagccccacc cagggccctgtcctgtgtctgccaccacctttgtctgatacttgtttccagggaagctgg 108- 98677.doc 200533758 gggaactgccacatctgaggaactggaataa >39579—at HG-U95AV2 attcatactgtcagggctgtgctcaatgactggatgttccctatatgcaaacaaaatcac aacggaattctttgatcctctctttgttgagcaaaagtatgaattaggagccgctctgtt tattggatgggcaggagcctcactgtgcataattggtggtgtcatattttgcttttcaat atctgacaacaacaaaacacccagatacacatacaacggggccacatctgtcatgtcttc tcggacaaagtatcatggtggagaagattttaaaacaacaaacccnnnnnnnnnnnnnnn naaaaatgcttatgtctaaaagagctcgctggcaagctgcctcttgagtttgttataaaa gcgaactgttcacaaaatgatcccatcaaggccctcccataattaacactcaaaactatt tttaaaatatgcatttgaagcatctgttgattgtatggatgtaagtgttcttacatagtt agttatatactaatcattttctgttgtggct >39633_at HG-U95Av2ctgttcaatg > 39409_at HG-U95Av2 ctggacacccatctctaaagcaggacgcctgccagggggatagtgggggcgtttttgcag taagggacccgaacactgatcgctgggtggccacgggcatcgtgtcctggggcatcgggt gcagcaggggctatggcttctacaccaaagtgctcaactacgtggactggatcaagaaag agatggaggaggaggactgagcccagaattcactaggttcgaatccagagagcagtgtgg a a a a a a a a a a a c a a a a a a c a a mmrmmmrmrmnrmrmmmnmma g a g t c t c t mma a a antnnnnnnnnanannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttgatgtact ttacctgaaacaacccaaagggcccctttctttcttctgaggattgcagaggatatagtt atcaatctctagttgtcactttcctcttccactttgataccattgggtcattgaatataa c > 39421_at HG-U95AV2 gacggtataacacatctactgaaaaagcaannnnnnnnnnnnnnnnatttaagccagccc ccacctagggtctatttgtgtggcagttattgggtttggtcacaaaacatcctgaaaatt cgtgcgtgggcttctttctccctggtacaaacgtatggaatgcttcttaaaggggaactg tcaagctggtgtcttcagccagatgacatgagagaatatcccagaaccctctctccaagg tgtttctagatagcacaggagannnnnnnnnnnnnnntccacagtccacggtacacagtc gggtgggccgcctcccctctcctgggagcattcgtcgtgcccagcctgagcagggcagct ggactgctgctgttcaggagccaccagagccttcctctctttgtaccacag > 3951 7_at HG-U95Av2 tcttaggggtcattatcacttaaataatactgtacctaggtctttcaaattaaaattata cctgaatgaagttgtttgtatacataaaggatatttgtgtacaattaccttttttccccc acacttgttttctttgtttttgttnnnnnnnnnnnnnnnnnnnnnnntnnactatgggat tcatttatgtctgtctttctatcataaagaattgatcaatatgtaaatatgtgatttgaa ccatggttgacttacaagtgtcactacagctttttagaaaacatagccctaatatatgtt aagcaggacccgggtgagccagtggnnttgcgctttatgtagagctggaagaaggccgtc catcctgtctcttgggcggacagtgtactttcctaatagggaagggaagcacaatggaaa tacccctgaaccg > 39532_at HG-U95Av2 attgccaccctgaaccagctctgtgccaccaagttccgagnnnnnnnnnnnnnnnnnnnn nncctcttcctgtacaaggagnnnggctaccnccgcctgccccctgggnccntggccnac aggctgcccaccactggctacctcgtctaccgccgggcagagtggcctgagacccagggg gctgtgacagaggaggagggcagtgggcagtcagaggcaagaagcagaggggaggagcaa gggtgccagggagatggggatgctggggtcaaagccagccccagggacattcgggaacag tctgagacaactgctgaagggggccagggtcaagcccaggaaggccctgctcagccaggg gaaccagaggcagagggaagccgggcagcagaggagnnnnnnnnnnnnnnnagaagggtc attcggggcgggagaccctgagcctgctgagaaatccttttagcgccagcaagccccacc cagggccctgtcctgtgtctgccaccacctttg tctgatacttgtttccagggaagctgg 108- 98677.doc 200533758 gggaactgccacatctgaggaactggaataa > 39579-at HG-U95AV2 attcatactgtcagggctgtgctcaatgactggatgttccctatatgcaaacaaaatcac aacggaattctttgatcctctctttgttgagcaaaagtatgaattaggagccgctctgtt tattggatgggcaggagcctcactgtgcataattggtggtgtcatattttgcttttcaat atctgacaacaacaaaacacccagatacacatacaacggggccacatctgtcatgtcttc tcggacaaagtatcatggtggagaagattttaaaacaacaaacccnnnnnnnnnnnnnnn naaaaatgcttatgtctaaaagagctcgctggcaagctgcctcttgagtttgttataaaa gcgaactgttcacaaaatgatcccatcaaggccctcccataattaacactcaaaactatt tttaaaatatgcatttgaagcatctgttgattgtatggatgtaagtgttcttacatagtt agttatatactaatcattttctgttgtggct > 39633_at HG-U95Av2

gacaaatacaagctctgccaggcggngntnnnnnnnnnnnnnnngaaggagctggccacn tggaccccgactgagtttcgggaatgtgactacaacaaattcatgagtgttctggacacc aacaaggactgcgaggtggactttgtggagtatgtgcgctcacttgcctgcctctgtctc tactgccacgagtacttcaanggactgcccctncagagcccccctgctnccnagtagcct ctgctccagggggtgcgctggctgtcgggggnctgggcatgtctcccacaccccctecta ccctctctcctgtacccctttcaatctggacttgcccaggtcttctgcgatcagttaacc cattttacctaggaggcccagagatgtgagggctccttcctcaggatgcccagcgaatga ggggtagagccactctgggncccagcctgcctgccgcacccctgtggcctcccttgtgga tgggaggaggcgggatctgctctgaggccctcgaggctcagcagagcgtgcaccaatgag accacgatgggaaagg >3 9640__at HG-U95Av2 atacagctctcttcagagtaactgtnaaccttttataaccaacactagagttnnntttnn aaaagacaagatatttataatgacgactngtatagcttttaagttatttttctagtatgt ggctttctntagccgtgntaacgnncaaactgttcatcnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagc ac aagge at t ggc c ct c t ggactcctttctccttttctttcctctctaggctgctcctgaatcctgttctctgacatc cgtggagcccctcctgcatccacctatgcctcctataagtccanttgaaatctcagcctc cttcaacattttcttctcgtgtgtggcccacatccctccacttctccaacttctgtttaa tctgatcacggctctttttaagccctggcagcattttggtccctgctccttgcccatagt aaannnnnnnnnnnnnnnnnnnnnnnnnnnnnagtttcaagtgggcaactctgctctcta tt >39663_at HG-U95Av2 ggtcagttatccttctctccttagccacataacttcttctctcatgaatcatccagtcat tccaatggcaaataagttctcctcacctacccttgagctgcaaggtgaattcnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaggt gggcaatgggcactccaatgaggcagccttgatcctccacagaaaagggtttgattgtcg gttctctagcaaaggcacagggctgttttgttctactactcagggaaagatattggtaca gaaacttttaaacaagtttattgtcgaaagtctcacaccttcatcactatccttgatgca ttcacctcccggcactcagaatataagtgagatcaacttgagtccaatggaaatcagcac attccgaatccagttgaggtgaacctgactttcacatttggattgagaatcattggcttt tatacctttcttggtttgacgtgcaataaagaagcacattattttagcttctggctactg tgag >39680_at HG-U95Av2 gtctcatcttgagtaaaagagaacccagccaactatgaagttccttgtctttgccttcat cttggctctcatggtttccatgattggagctgattcatctgaagagaaatttttgcgtag aattggaagattcggttatgggtatggcccnnnnnnnnnnnnnnnagaacaaccactata cccacaaccataccaaccacaataccaacaatataccttttaatatcatcagtaactgca ggacatgattattgaggcttgattggcaaatacgacttctacatccatattctcatcttt cataccatatcacactactaccactttttgnangaatcatcaaagagcaatgcaaatgna aaacactataatttactgtatactctttgtttcaggatacttgcc >39681_at HG-U95Av2 tgcagcagcacatggaggtccacgcgggcgtgcgcagctacatctgcagtgagtgcaacc gcnccttccccagccacacggctctcaaacgccacctgcgctcacatacaggcgaccacc 109 - 98677.doc 200533758 cctannnnnnnnnnnnnnnnggcagctgcttccgggnnnnnnnnnnnnnnnagagccaca aacgcatccacacgggtgagaaaccctacgagtgcaatggctgtggcaagaagttcagcc tcaagcatcagctggagacgcactatagggtgcacacaggtgagaagccctttgagtgta agctctgccaccagcgctcccgggactactcggccatgatcaagcacctgagaacgcaca acggcgcctcgccctaccagtgcaccatctgcacagagtactgccccagcctctcctcca tgcagaagcacatgaagggccacaagcccgaggagatcccgcccgactggaggatagaga agacgtacctctacctgtgctatgtgtgaag >39728__at HG-U95Av2 tgtgccctgggtcaccgtcaatgggaaacccttggaagatcagacccagctccttaccct tgtctgccagttgtaccagggcaagaagccggatgtctgcccttcctcaaccagctccct caggagtgtttgcttcaagt gat ggccggt gage tgcggagagc teat ggaaggcgagtjg ggaacccggctgcctgcctttttttctgatccagaccctcggcacctgctacttaccaac tggaaaattttatgcatcccatgaagcccagatacacaaaattccaccccatgatcaaga atcctgctccactaagaatggtgctaaagta >39742_at HG-U95AV2 ggaaaatctagtttcacagctatttgaatttttttctggatttactatataactcttatt ttttaaaagatcattctgttctttcaaggagaaataagcctaaaagaagaaaaacaaaaagacaaatacaagctctgccaggcggngntnnnnnnnnnnnnnnngaaggagctggccacn tggaccccgactgagtttcgggaatgtgactacaacaaattcatgagtgttctggacacc aacaaggactgcgaggtggactttgtggagtatgtgcgctcacttgcctgcctctgtctc tactgccacgagtacttcaanggactgcccctncagagcccccctgctnccnagtagcct ctgctccagggggtgcgctggctgtcgggggnctgggcatgtctcccacaccccctecta ccctctctcctgtacccctttcaatctggacttgcccaggtcttctgcgatcagttaacc cattttacctaggaggcccagagatgtgagggctccttcctcaggatgcccagcgaatga ggggtagagccactctgggncccagcctgcctgccgcacccctgtggcctcccttgtgga tgggaggaggcgggatctgctctgaggccctcgaggctcagcagagcgtgcaccaatgag accacgatgggaaagg > 3 9640__at HG-U95Av2 atacagctctcttcagagtaactgtnaaccttttataaccaacactagagttnnntttnn aaaagacaagatatttataatgacgactngtatagcttttaagttatttttctagtatgt ggctttctntagccgtgntaacgnncaaactgttcatcnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagc ac aagge at t ggc c ct c t ggactcctttctccttttctttcctctctaggctgctcctgaatcctgttctctgacatc cgtggagcccctcctgcatccacctatgcctcctataagtccanttgaaatctcagcctc cttcaacattttcttctcgtgtgtggcccacatc cctccacttctccaacttctgtttaa tctgatcacggctctttttaagccctggcagcattttggtccctgctccttgcccatagt aaannnnnnnnnnnnnnnnnnnnnnnnnnnnnagtttcaagtgggcaactctgctctcta tt > 39663_at HG-U95Av2 ggtcagttatccttctctccttagccacataacttcttctctcatgaatcatccagtcat tccaatggcaaataagttctcctcacctacccttgagctgcaaggtgaattcnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaggt gggcaatgggcactccaatgaggcagccttgatcctccacagaaaagggtttgattgtcg gttctctagcaaaggcacagggctgttttgttctactactcagggaaagatattggtaca gaaacttttaaacaagtttattgtcgaaagtctcacaccttcatcactatccttgatgca ttcacctcccggcactcagaatataagtgagatcaacttgagtccaatggaaatcagcac attccgaatccagttgaggtgaacctgactttcacatttggattgagaatcattggcttt tatacctttcttggtttgacgtgcaataaagaagcacattattttagcttctggctactg tgag > 39680_at HG-U95Av2 gtctcatcttgagtaaaagagaacccagccaactatgaagttccttgtctttgccttcat cttggctctcatggtttccatgattggagctgattcatctgaagagaaatttttgcgtag aattggaagattcggttatgggtatggcccnnnnnnnnnnnnnnnagaacaaccactata cccacaaccataccaaccacaataccaacaatataccttttaatatcatcagtaactgca ggac atgattattgaggcttgattggcaaatacgacttctacatccatattctcatcttt cataccatatcacactactaccactttttgnangaatcatcaaagagcaatgcaaatgna aaacactataatttactgtatactctttgtttcaggatacttgcc > 39681_at HG-U95Av2 tgcagcagcacatggaggtccacgcgggcgtgcgcagctacatctgcagtgagtgcaacc gcnccttccccagccacacggctctcaaacgccacctgcgctcacatacaggcgaccacc 109 - 98677.doc 200533758 cctannnnnnnnnnnnnnnnggcagctgcttccgggnnnnnnnnnnnnnnnagagccaca aacgcatccacacgggtgagaaaccctacgagtgcaatggctgtggcaagaagttcagcc tcaagcatcagctggagacgcactatagggtgcacacaggtgagaagccctttgagtgta agctctgccaccagcgctcccgggactactcggccatgatcaagcacctgagaacgcaca acggcgcctcgccctaccagtgcaccatctgcacagagtactgccccagcctctcctcca tgcagaagcacatgaagggccacaagcccgaggagatcccgcccgactggaggatagaga agacgtacctctacctgtgctatgtgtgaag > 39728__at HG-U95Av2 tgtgccctgggtcaccgtcaatgggaaacccttggaagatcagacccagctccttaccct tgtctgccagttgtaccagggcaagaagccggatgtctgcccttcctcaaccagctccct caggagtgtttgcttcaagt gat ggccggt gage tgcggagagc teat ggaaggcgagtjg ggaacccggctgcctgcctttttttctgatccagaccctcggcacctgctact taccaac tggaaaattttatgcatcccatgaagcccagatacacaaaattccaccccatgatcaaga atcctgctccactaagaatggtgctaaagta > 39742_at HG-U95AV2 ggaaaatctagtttcacagctatttgattttttctggatttactatataactctaatagatagatagatagatagatagat

aaattctgtataaaactgtaatncctttgtattcatgtttacagtgctattactataatt caaaattatgtatgtgacttagagttatataatcataatttatgtttatttcaaatatct aagtttattgcttggatttctagtgagagctgttgaatttggtgatgtcaaatgtttcta gggtttttttagtttgtttttattgaaaaatttaattatttatgctataggtgatattct ctttgaataaacctataatagaaaatagcagacaacataaacatctttgtaaatatcaaa cctaatacatttcttgtccagtgataaaacaactgg >39781_at HG-U95Av2 actcccctgggcatcttctggcttgactggatggaaggagacttaggaacctaccagttg gccatgatgtcttttcttctttttcttttttttaacaaaacagaacaaaaccaaaaaatg tccanaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaanaaaaaaanaannnnnnnnnnatc cagtcaagccatgatgtcttttcttct >39791_at HG-U95Av2 gtaacagacattgttttgccaacattgcctatttcagtggcacgtcatctagttttaaaa aaataaaacattttaaatggacaganaaaaaaaanannnnnnnntttaactcgtaagtgn nnnnnnnnnnnnnnnnngacatgtccnnctttctctccagttcnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnagttgtactctgcttgaggggaagaaggctcctgctctgctgtgta ggtagtcataggaattgtattcttaatgtacaggcactaattgtcatctgtgatgtacat 111 a t g nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnt at gt gt g t g tatgtgtgtgttttgtaaaatctgtaaatagcacatgaccaaatgaacatattg >39805_at HG-U95Av2 aggcatccatgatgccattatggctttccctgaagggtacaggacacannnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntcnaatganag ggccatccaggcttctctggccaaagtctgtgccaaccgcnnccaccntngtagtggcac acaggctctcaactgtggtcaatgctgaccagatcctcgtcatcaaggatggctgcatcg tggagaggggacgacacgaggctctgttgtcccgaggtggggtgtatgctgacatgtggc agctgcagcagggacaggaagaaacctctgaagacactaagcctcagaccatggaacggt gacaaaagtttg >39826_f_at HG-U95Av2 cttaaacgcagctgccaggtgtaatttttcaagtgtcaaagatcccaagtgatccctgac acccaccccttcctactcttacattcatgcgtctnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnntgctccgatcagaanaannanannnaaaanaacnnncanncacannnggnccn tnnanancagnaananacacaanccacctccacgacctccgacctcccccctccctccgg ntngctctgaggnagcacgtgcctcttccttcaccctgggccnggctggggcgggagcag ccnagctgctctctggatgtcacaccactgttaactgtca >3 98 7 8_at HG-U95Av2 atggatgtcaatgacaccagcccagttgtcatttctccaccgtctaatacttcctttaag 110- 98677.doc 200533758 ttggtgcccctctcagccattcctg ηηηηηηηηηηηηηπηηηηηηηηηηηηηηηηηηηηη nnnnctggaatgaacgctgaactaaagnnnnctatagtnagtgnaancnntaannncnna tnnnnnnnngnnnnnnnnacaggtaacattactnnnnaanaaaaaccancncctactgat gtgggattgcatcgtttggtggtcaacataagtgancctggggtanccctaagtctttgc acacgcttgtgcttgtattcctttatgttnnnnnnnnnnnnnnnnnngcctcctatatct atgacttgatccgcaggactatggagaccccgttggacaggaacataggggatagtagcc aaccctatcaaaatgaggactatctaaccatcatgattgccatcatcgccggtnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng gt nnnnt gt c gccatgcatcaaggttca aagcagctcagaggagcaagcaaggtgccgaatggatgtcccc >39959一at HG-U95Av2 cttatggcattgacaaagagaagaccatccaccttaccctgaaagtggtgaagcccagtg atgaggagctgcccttgtttcttgtggagtcaggtgatgaggcaaagaggcacctcctcc aggtgcgaaggtccagctcagtggcacaagtgaaagcaatgatcgagactaagacgggta taatccctgagacccagattgtgacttgcaatggaaagagactggaagatgggaagatga tggcagattacggcatcagaaagggcaa >39966_at KG-U95Av2 caggctgacttggatgtgaactgtcttcagaataatttaacctaaagcagagcaagaagaaaattctgtataaaactgtaatncctttgtattcatgtttacagtgctattactataatt caaaattatgtatgtgacttagagttatataatcataatttatgtttatttcaaatatct aagtttattgcttggatttctagtgagagctgttgaatttggtgatgtcaaatgtttcta gggtttttttagtttgtttttattgaaaaatttaattatttatgctataggtgatattct ctttgaataaacctataatagaaaatagcagacaacataaacatctttgtaaatatcaaa cctaatacatttcttgtccagtgataaaacaactgg > 39781_at HG-U95Av2 actcccctgggcatcttctggcttgactggatggaaggagacttaggaacctaccagttg gccatgatgtcttttcttctttttcttttttttaacaaaacagaacaaaaccaaaaaatg tccanaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaanaaaaaaanaannnnnnnnnnatc cagtcaagccatgatgtcttttcttct > 39791_at HG-U95Av2 gtaacagacattgttttgccaacattgcctatttcagtggcacgtcatctagttttaaaa aaataaaacattttaaatggacaganaaaaaaaanannnnnnnntttaactcgtaagtgn nnnnnnnnnnnnnnnnngacatgtccnnctttctctccagttcnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnagttgtactctgcttgaggggaagaaggctcctgctctgctgtgta ggtagtcataggaattgtattcttaatgtacaggcactaattgtcatctgtgatgtacat 111 a t g nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnt at gt gt g t g tatgtgtgtgttttgtaaaatctgt aaatagcacatgaccaaatgaacatattg > 39805_at HG-U95Av2 aggcatccatgatgccattatggctttccctgaagggtacaggacacannnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnntcnaatganag ggccatccaggcttctctggccaaagtctgtgccaaccgcnnccaccntngtagtggcac acaggctctcaactgtggtcaatgctgaccagatcctcgtcatcaaggatggctgcatcg tggagaggggacgacacgaggctctgttgtcccgaggtggggtgtatgctgacatgtggc agctgcagcagggacaggaagaaacctctgaagacactaagcctcagaccatggaacggt gacaaaagtttg > 39826_f_at HG-U95Av2 cttaaacgcagctgccaggtgtaatttttcaagtgtcaaagatcccaagtgatccctgac acccaccccttcctactcttacattcatgcgtctnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnntgctccgatcagaanaannanannnaaaanaacnnncanncacannnggnccn tnnanancagnaananacacaanccacctccacgacctccgacctcccccctccctccgg ntngctctgaggnagcacgtgcctcttccttcaccctgggccnggctggggcgggagcag ccnagctgctctctggatgtcacaccactgttaactgtca > 3 98 7 8_at HG-U95Av2 atggatgtcaatgacaccagcccagttgtcatttctccaccgtctaatacttcctttaag 110- 98677.doc 200533758 ttggtgcccctctcagccattcct g ηηηηηηηηηηηηηπηηηηηηηηηηηηηηηηηηηηη nnnnctggaatgaacgctgaactaaagnnnnctatagtnagtgnaancnntaannncnna tnnnnnnnngnnnnnnnnacaggtaacattactnnnnaanaaaaaccancncctactgat gtgggattgcatcgtttggtggtcaacataagtgancctggggtanccctaagtctttgc acacgcttgtgcttgtattcctttatgttnnnnnnnnnnnnnnnnnngcctcctatatct atgacttgatccgcaggactatggagaccccgttggacaggaacataggggatagtagcc aaccctatcaaaatgaggactatctaaccatcatgattgccatcatcgccggtnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnng gt nnnnt gt c gccatgcatcaaggttca aagcagctcagaggagcaagcaaggtgccgaatggatgtcccc > 39959 a at HG-U95Av2 cttatggcattgacaaagagaagaccatccaccttaccctgaaagtggtgaagcccagtg atgaggagctgcccttgtttcttgtggagtcaggtgatgaggcaaagaggcacctcctcc aggtgcgaaggtccagctcagtggcacaagtgaaagcaatgatcgagactaagacgggta taatccctgagacccagattgtgacttgcaatggaaagagactggaagatgggaagatga tggcagattacggcatcagaaagggcaa > 39966_at KG-U95Av2 caggctgacttggatgtgaactgtcttcagaataatttaacctaaagcagagcaagaaga

gaggaagcgggggtagtgggtggggggtaggggaagaannattatctcctcttgtacaga gtctatttcttgtaaccatttgttaaactcttttctttttctgatctcatggcatgcttt tatgtattttgtacaggaggcaaaaaaaatacttaaaataagcaaagaaactgaacagaa ttgcatacattgggttgttttttctgtgctgtctgtacattgcttctgctgctgtgattt ctaaacctgtgctgttattcaactgactttt >40049_dt HG-U95AV2 cctccagggtgattttatgatcagtgttgttgctctaggaagacatttttccgtttgctt ttgttccaatgtcaatgtgaacgtccacatgaaacctacacactgtcatgcttcatcatt ccctctcatctcaggtagaanggttgacacagttgtagggttacagagacctatgtaaga attcagaagacccctgactcatcatttgtggcagtncccttataattggtgcannnnnnn nnnnnnnnnnnnnttagatcctggtttcataacttcctgtacttgaagtctaaaagcaga aaataaaggaagcaagttttcttccatgattttaaattgtgatcgagttttaaattgata ggagggaacatgtcctaattcttctgt >40051_at HG-U95AV2 tcattgtccaggaataagattggcgtggtgcccatgacatcaccgtcactctgcctaaaa gcactctagagctacttgttcacgtggagaggaaggatattttgcgaancaacagnccgc aggtggagagccctgttcacctgatagggtctagctgtgacagtaaatataataccgctg tttccttgggtacagatttgagtgttcatgtgatgagactgtaaacctcatttttcggtt cctctgtttaaaaaaacatctgaaggatgaactaaggctgctggtgccctgagcaactga taatgcaaatgtggacaaagtgtctgttttctactctagcctgttcatatggaccaaatt tcaacaaggaactcaaggaaaatttgtacctgccgtatttatgctttcatgtaaaa >4 00 69__at HG-U95Av2 ctgccttcttgttccagctaggcaatgcntttttttttttttttgaagcagttctcttta taaagtgttattttgatagtttgtggattctaaaatatatatatatttatataaacacca tataagtcaaatatgtatttaacaaagcaatatgtattcattcactttcaagatttgttt tggtgtcaaaataacatgaaaaggtagatggagttgcttctgttgaattagctctgccac caatatgtatcttcatacacgtttggaaatgtttcctgcagcattaggtatgacttgttc tgagtactgcttccggtgctaaaatgaacaaagaatttgtacttaatggcatggactctg gagaatctatgcgaatcaacctttctaccttaatatctccccaaaaatgtatagtgcctt gtttttatgtacagtttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnatgatggtttnnn nnnnnnnnnnnnnttttactctcaaatagtcaaaataaaaacatctcaatttctaatanc ngttgtaaacannnngtacacatgtcattttgtgatataggactcccaaataaa >40088—at HG-U95Av2 atgtatacagttgcaagtctggacaaatgtatagaataaaccttttatttaagttgtnnn nnnnnnnnnnnnnnnaanngnnnnngggnnncnntgnnnnnnnnnnnnnnnnnnnnnnnn tnnnnacaaatcagatcagatgttcatcctnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttgattcgaagggtcttaaagaattt ttttaatcgtcaaccacttttaaacataaagaattcacacaactactttcatgaattttt 111 - 98677.doc 200533758 taatcccattgcaaacattattccaagagtatcccagtattagcaatactggaatatagg cacattaccattcatagtaagaattctggtgtttacacaaccaaatttgatgcgatctgc tcagtaatataatttgccatttttattagaaatttaatttctteatgtgatgtcatgaaa ctgtacatactgcagtgtgaatttttttgttttgttttttaatcttttagtgtttacttc ctgcagtgaatttg >40091_at HG-U95Av2 aaaggctcgattttgtatctgcaggcagacacggatctgagaatctttattgagaaagag cacttaagagaatattttaagtattgcatctgtataagtaagaaaatattttgtctaaaa tgcctcagtgtatttgtatttttttgcaagtgaaggtttacaatttacaaagtgtgtatt aaaaaaaacaaaaagaacaaaaaaatctgcagaaggaaaaatgtgtaattttgttctagt tttcagtttgtatatacccgtacaacgtgtcctcnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnngcgagcgtgcaccatccctttttgaagtgtaggcagacacagggacttgaa gttgttactaactaaactctctttgggaatgtttgtctcatcc >40126_at HG-U95Av2 ttaattagggatcttgctgcttttctttttctacacgaagttttcattaaagccacagan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttaaatgaa ttagaaactatttgaggctataaaaatgtccttgagtttggagcctgagctctggnnnnngaggaagcgggggtagtgggtggggggtaggggaagaannattatctcctcttgtacaga gtctatttcttgtaaccatttgttaaactcttttctttttctgatctcatggcatgcttt tatgtattttgtacaggaggcaaaaaaaatacttaaaataagcaaagaaactgaacagaa ttgcatacattgggttgttttttctgtgctgtctgtacattgcttctgctgctgtgattt ctaaacctgtgctgttattcaactgactttt > 40049_dt HG-U95AV2 cctccagggtgattttatgatcagtgttgttgctctaggaagacatttttccgtttgctt ttgttccaatgtcaatgtgaacgtccacatgaaacctacacactgtcatgcttcatcatt ccctctcatctcaggtagaanggttgacacagttgtagggttacagagacctatgtaaga attcagaagacccctgactcatcatttgtggcagtncccttataattggtgcannnnnnn nnnnnnnnnnnnnttagatcctggtttcataacttcctgtacttgaagtctaaaagcaga aaataaaggaagcaagttttcttccatgattttaaattgtgatcgagttttaaattgata ggagggaacatgtcctaattcttctgt > 40051_at HG-U95AV2 tcattgtccaggaataagattggcgtggtgcccatgacatcaccgtcactctgcctaaaa gcactctagagctacttgttcacgtggagaggaaggatattttgcgaancaacagnccgc aggtggagagccctgttcacctgatagggtctagctgtgacagtaaatataataccgctg tttccttgggtacagatttgagtgttcatgtgatgagactgtaaacctcatttttcggtt cctctgtttaaaaaaacatctgaaggatgaactaaggctg ctggtgccctgagcaactga taatgcaaatgtggacaaagtgtctgttttctactctagcctgttcatatggaccaaatt tcaacaaggaactcaaggaaaatttgtacctgccgtatttatgctttcatgtaaaa > 4 00 69__at HG-U95Av2 ctgccttcttgttccagctaggcaatgcntttttttttttttttgaagcagttctcttta taaagtgttattttgatagtttgtggattctaaaatatatatatatttatataaacacca tataagtcaaatatgtatttaacaaagcaatatgtattcattcactttcaagatttgttt tggtgtcaaaataacatgaaaaggtagatggagttgcttctgttgaattagctctgccac caatatgtatcttcatacacgtttggaaatgtttcctgcagcattaggtatgacttgttc tgagtactgcttccggtgctaaaatgaacaaagaatttgtacttaatggcatggactctg gagaatctatgcgaatcaacctttctaccttaatatctccccaaaaatgtatagtgcctt gtttttatgtacagtttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnatgatggtttnnn nnnnnnnnnnnnnttttactctcaaatagtcaaaataaaaacatctcaatttctaatanc ngttgtaaacannnngtacacatgtcattttgtgatataggactcccaaataaa > 40088-at HG-U95Av2 atgtatacagttgcaagtctggacaaatgtatagaataaaccttttatttaagttgtnnn nnnnnnnnnnnnnnnaanngnnnnngggnnncnntgnnnnnnnnnnnnnnnnnnnnnnnn tnnnnacaaatcagatcagatgttcatcctnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnttgattcgaagggtcttaaagaattt ttttaatcgtcaaccacttttaaacataaagaattcacacaactactttcatgaattttt 111 - 98677.doc 200533758 taatcccattgcaaacattattccaagagtatcccagtattagcaatactggaatatagg cacattaccattcatagtaagaattctggtgtttacacaaccaaatttgatgcgatctgc tcagtaatataatttgccatttttattagaaatttaatttctteatgtgatgtcatgaaa ctgtacatactgcagtgtgaatttttttgttttgttttttaatcttttagtgtttacttc ctgcagtgaatttg > 40091_at HG-U95Av2 aaaggctcgattttgtatctgcaggcagacacggatctgagaatctttattgagaaagag cacttaagagaatattttaagtattgcatctgtataagtaagaaaatattttgtctaaaa tgcctcagtgtatttgtatttttttgcaagtgaaggtttacaatttacaaagtgtgtatt aaaaaaaacaaaaagaacaaaaaaatctgcagaaggaaaaatgtgtaattttgttctagt tttcagtttgtatatacccgtacaacgtgtcctcnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnngcgagcgtgcaccatccctttttgaagtgtaggcagacacagggacttgaa gttgttactaactaaactctctttgggaatgtttgtctcatcc > 40126_at HG-U95Av2 ttaattagggatcttgctgcttttctttttctacacgaagttttcattaaagccacagan nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttaaatgaa ttagaaactatttgaggctataaaaatgtccttgagtt tggagcctgagctctggnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagagtaagnnnnnnnnnnnn nnnnnntatccgttcttcacttagcaggaatatgaaagaaaggcacatgtttaagaggaa tacctaaaggtttttctaaattccaacatttaaaaggcaattgtgggctatttttatttt ttaatattttgaaataaagtttagtgtctagggctgggagccaggactgatcttccattt ett >40153_at HG-U95Av2 ggtactcccgctcagtgcttctcatcacccagcacctcagcctggtggagcaggctgacc acatcctctttctggaaggaggcgctatccgggaggggggaacccaccagcagctcatgg agaaaaaggggtgctactgggccatggtgcaggctcctgcagatgctccagaatgaaagc cttctcagacctgcgcactccatctccctcccttttcttctctctgtggtggagaaccac agctgcagagtaggcagctgcctccaggatgagttacttgaaatttgccttgagtgtgtt acctcctttccaagctcctcgtgataatgcagacttcctggagtacaaacacaggatttg taattccttactgtaacggagtttagagccagggctgatgctttggtgtggccagcactc tgaaactgagaaatgttcagaatgtacggaaagatgatcagctattttcaacataactga agg >40171_at HG-U95AV2 aatgtatgcgccagggtgcttccgtggggcannnnnnnnnnnnnnnccatccaagcccaa ggacctgggataaactgggagaactatggcagctacttgcatcgacttgtacctcactta gcccttggg >40177__at HG-U95AV2 atattatactttagggcaaccctagttggcagctttgagagaagttcttcattacagaag aattccattaaacatggaaggaataactaaactaaaaatcatcactttgcaattctgaat gaaatnnnnnnnnnnnnnnnnnatttattattggataaaaccatcagatataaggttaat agggaacttgacagcagacagagggaagag >40199_at HG-U95Av2 gtttcacctctttgctccctgagttcactctccgaagtctgatccctgccaaaaagtggc tggaagagtcccttagtactcttctagcatttagatetacactctcgagnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaagaa aagcgcagagaaatcggtgtctgacgattttggaaatgagaacaatctcaaaaaaaaaaa aaaaaaaaaaaaaaaaannnnnnngaaaagagaaaaaaaagactagccagccaggaagat gaatcctagcttcttccattggaaaatttaagacaagttcaacaacaaaacatttgctct ggggggcagggaaaacacagatgtgttgcaaaggtaggttgaagggacctctctcttacc a >40214_at HG-U95Av2 gctacgtaaggcagcccgtgaaccaagcctactttttctgtcatntgattcaccatgtca gtaagcgtatctggaattactcttattccactatcacaaatccatataagatcatacttt 112- 98677.doc 200533758 gcaacttcatatcctggcattaaattattaattttaggattaatgccaacttttttgcca cctataaacaatctagcatcaacatttggatattttccannnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnntcatgatettgtacacaaaggagcacttcatatttgggataatccaat tcaaagaatgtttccaggttgttgattaagttaggatctacccctttcagtggtttcaga agagagacacctgggagcttgctataaggctgtttgtcagttgccttcttgttgaggt >40215_at HG-U95AV2 caatgtccactcaagttgcaatgcaaaactctggctcatattcaatttctcagtttcaat ccagaatgatcaggtggaccaaactacgaattaacatgcttcctgctacaataatttgtg agccaatttcagaatgctttgttgccagtttaattattggatgggcagcccaccatgtgt tcagatgggatattatggtatttttcatgtgtcattgcctggcatggtttatatttgact acattcaactcaggggtgtccagggtggcacactgtgtttttcaaaacttgattatgcag tcgeetggtteatccgcgaatccatgacaatatacatttttttgtctgcattatgggacc caactataagctggagaactggtcgctacagattacgctgtgggggtacagcagaggaaa tnnnnnnnnnnnnnnnnnnnnnnnntgactgtatataaaggaaaaaagagaagtattata aattatgtttatataaatgcttttaaaaatctaccttctgtagttttatcacatgtatg >4 02 36__ar HG-U95Av2 ctttcctcgtgttgggcctgagtgtcttgaccacttacggagttcatgccatcnncaggcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnagagtaagnnnnnnnnnnnn nnnnnntatccgttcttcacttagcaggaatatgaaagaaaggcacatgtttaagaggaa tacctaaaggtttttctaaattccaacatttaaaaggcaattgtgggctatttttatttt ttaatattttgaaataaagtttagtgtctagggctgggagccaggactgatcttccattt ett > 40153_at HG-U95Av2 ggtactcccgctcagtgcttctcatcacccagcacctcagcctggtggagcaggctgacc acatcctctttctggaaggaggcgctatccgggaggggggaacccaccagcagctcatgg agaaaaaggggtgctactgggccatggtgcaggctcctgcagatgctccagaatgaaagc cttctcagacctgcgcactccatctccctcccttttcttctctctgtggtggagaaccac agctgcagagtaggcagctgcctccaggatgagttacttgaaatttgccttgagtgtgtt acctcctttccaagctcctcgtgataatgcagacttcctggagtacaaacacaggatttg taattccttactgtaacggagtttagagccagggctgatgctttggtgtggccagcactc tgaaactgagaaatgttcagaatgtacggaaagatgatcagctattttcaacataactga agg > 40171_at HG-U95AV2 aatgtatgcgccagggtgcttccgtggggcannnnnnnnnnnnnnnccatccaagcccaa ggacctgggataaactgggagaactatggcagctacttgcatcgacttgtacctcactta gcccttggg > 40177__at HG-U95AV2 atattatactttagggcaaccctagttggcagctttgagagaagttcttcattacaga ag aattccattaaacatggaaggaataactaaactaaaaatcatcactttgcaattctgaat gaaatnnnnnnnnnnnnnnnnnatttattattggataaaaccatcagatataaggttaat agggaacttgacagcagacagagggaagag > 40199_at HG-U95Av2 gtttcacctctttgctccctgagttcactctccgaagtctgatccctgccaaaaagtggc tggaagagtcccttagtactcttctagcatttagatetacactctcgagnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaagaa aagcgcagagaaatcggtgtctgacgattttggaaatgagaacaatctcaaaaaaaaaaa aaaaaaaaaaaaaaaaannnnnnngaaaagagaaaaaaaagactagccagccaggaagat gaatcctagcttcttccattggaaaatttaagacaagttcaacaacaaaacatttgctct ggggggcagggaaaacacagatgtgttgcaaaggtaggttgaagggacctctctcttacc a > 40214_at HG-U95Av2 gctacgtaaggcagcccgtgaaccaagcctactttttctgtcatntgattcaccatgtca gtaagcgtatctggaattactcttattccactatcacaaatccatataagatcatacttt 112- 98677.doc 200533758 gcaacttcatatcctggcattaaattattaattttaggattaatgccaacttttttgcca cctataaacaatctagcatcaacatttggatattttccannnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnntcatgatettgtacacaaaggagcact tcatatttgggataatccaat tcaaagaatgtttccaggttgttgattaagttaggatctacccctttcagtggtttcaga agagagacacctgggagcttgctataaggctgtttgtcagttgccttcttgttgaggt > 40215_at HG-U95AV2 caatgtccactcaagttgcaatgcaaaactctggctcatattcaatttctcagtttcaat ccagaatgatcaggtggaccaaactacgaattaacatgcttcctgctacaataatttgtg agccaatttcagaatgctttgttgccagtttaattattggatgggcagcccaccatgtgt tcagatgggatattatggtatttttcatgtgtcattgcctggcatggtttatatttgact acattcaactcaggggtgtccagggtggcacactgtgtttttcaaaacttgattatgcag tcgeetggtteatccgcgaatccatgacaatatacatttttttgtctgcattatgggacc caactataagctggagaactggtcgctacagattacgctgtgggggtacagcagaggaaa tnnnnnnnnnnnnnnnnnnnnnnnntgactgtatataaaggaaaaaagagaagtattata aattatgtttatataaatgcttttaaaaatctaccttctgtagttttatcacatgtatg > 4 02 36__ar HG-U95Av2 ctttcctcgtgttgggcctgagtgtcttgaccacttacggagttcatgccatcnncaggc

tggaggcctggagcctcgctctcctcgcgctgtttcttgttctcttcgttgccatcgttc tcaccatctggaggcagccccagaatcaacgaaaagtagccttcatggttccattct >40240_at HG-U95AV2 tctcgctgcctcacaagcagtgacacctcgggtcctttccgttgctatggtgaaaattcc tggatggaatggatcacatgagggtttcttgttgcttttggagggtgtgggggatatttt gttttggtttttctgcaggttccatgaaaacagcccttttccaagcccattgtttctgtc atggtttccatctgtcctgagcaagtcattcctttgttatttagcatttcgannnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnac c tetageate gann nnnnnnnnnnnnntnanctgacggcatggaatgtataaatgagggtgggtccttctgcag atactctaatcactacattgctttttctataaaactacccataagcctttaacctttaaa gaaaaatgaaaaaggttagtgtttgggggccgggggaggactgaccgcttcataagccag tacg >40290_f_at HG-U95Av2 agacaggacagtttcccaggaagatgggcagagacttgagtgngcnnnnnncnnnnncac agagacgtgccangcggtgttggcgctcggggcgagatgctgcccttctttngcacgann cntggcctcttgcttggcgtgataaccctgtcatcttcccaaagctcatttatgagccac cagaggctcct >40310_at HG-U95Av2 tttccgtctttttgatgagaac a at nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaagacct acctggagtggcccatggacgaggctcagcgggaaggattttgggtaaatctgagagctg cgataaagtcctaggttcccatatttaagaccagtctttgtctagttgggatcttnnnnn nnnnnnnnnnnnnnnnnnnnattcagacataattatataaaaactacgtggatgtaccgt catttgaggacttgcttactaaaactacaaaacttcaaattttgtctggggtgctgtttt ataaacatatgccagatttaaaaattggtttttggtttttcttttttctatgagataacc atgatcataagtct >40314_at HG-U95Av2 ctgtgggccaagacaccagccctgtcctagcccttcagtaannnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnngnnaagacaagcccctcagcaggagagaggcccagaggctc cagctggccaccgtgccccacaagatggcccctgtgtggttccctttaccttggcttcct ggcccagtccctgcctctccacctgcaccctgcttcctnggcccagtcccaggttggagt ccctctgcatagctgactactcatgcattg c nnnnnnnnnnnnnnnnnnnnnnnnnnnnc aacaccaaacgtggttgccacatttcatcagacagacacctccctctggagatgcagttg agtgacaaccttgttacattgtagcctagaccaattctgtgtggatatttaagtgaacat gtttacaatttttgtatatatcactctctccctctcctgaaagaccagagattgtgtatt ttcagtgtcccatgttccgactgc >40322 at HG-U95Av2 113- 98677.doc 200533758 ttgctgtctgatctttgtagactgttcctgtttgctgggagcttctctgctgcttaaatt gttcgtcctcccccactccctcctatcgttggtttgtctagaacactcagctgcttcttt ggtcatccttgttttctaactttatgaactccctctgtgtcactgtatgtga >40333_at HG-U95Av2 agcatcactcacagcgggccaggaagaagaanaagnactgccggcgcnactcgctctatg tggactnnnnnnnnnnnnnnnnnnnnnnnnctnggattntnggccccaccaggctaccag gccttctactgccatggggactgcccctttccactggctgaccacctcaactcaaccaac catgccattgtgcagaccctggtcaattctgtcaattccagtatccccaaagcctgttgt nnnnnnnnnnnnnnnnnnnncatctccatgctgtacctggatgagtatgataaggtggta ctgaaaaattatcaggagatggtagtagagggatgtgggtgccgctgagatcaggcagtc cttgaggatagacagatatacacaccacacacacacaccacatacaccacacacacacgt tcccatccactcacccacacactacacagactgcttccttatagctggacttttatttna aaaaaaaaaaaaaaaanggaaaaaatccctaaacattcaccttgaccttatttatgactt tacgtgc >40362_at HG-U95Av2 tgtcacttggtgatacagctctgcagaacctggagcagctgctagacgggccagaagccc agggcagctgggcagagctggcagagcgtctggggctgcgcagcctggtagacacgtacctggaggcctggagcctcgctctcctcgcgctgtttcttgttctcttcgttgccatcgttc tcaccatctggaggcagccccagaatcaacgaaaagtagccttcatggttccattct > 40240_at HG-U95AV2 tctcgctgcctcacaagcagtgacacctcgggtcctttccgttgctatggtgaaaattcc tggatggaatggatcacatgagggtttcttgttgcttttggagggtgtgggggatatttt gttttggtttttctgcaggttccatgaaaacagcccttttccaagcccattgtttctgtc atggtttccatctgtcctgagcaagtcattcctttgttatttagcatttcgannnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnac c tetageate gann nnnnnnnnnnnnntnanctgacggcatggaatgtataaatgagggtgggtccttctgcag atactctaatcactacattgctttttctataaaactacccataagcctttaacctttaaa gaaaaatgaaaaaggttagtgtttgggggccgggggaggactgaccgcttcataagccag tacg > 40290_f_at HG-U95Av2 agacaggacagtttcccaggaagatgggcagagacttgagtgngcnnnnnncnnnnncac agagacgtgccangcggtgttggcgctcggggcgagatgctgcccttctttngcacgann cntggcctcttgcttggcgtgataaccctgtcatcttcccaaagctcatttatgagccac cagaggctcct > 40310_at HG-U95Av2 tttccgtctttttgatgagaac a at nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaa gacct acctggagtggcccatggacgaggctcagcgggaaggattttgggtaaatctgagagctg cgataaagtcctaggttcccatatttaagaccagtctttgtctagttgggatcttnnnnn nnnnnnnnnnnnnnnnnnnnattcagacataattatataaaaactacgtggatgtaccgt catttgaggacttgcttactaaaactacaaaacttcaaattttgtctggggtgctgtttt ataaacatatgccagatttaaaaattggtttttggtttttcttttttctatgagataacc atgatcataagtct > 40314_at HG-U95Av2 ctgtgggccaagacaccagccctgtcctagcccttcagtaannnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnngnnaagacaagcccctcagcaggagagaggcccagaggctc cagctggccaccgtgccccacaagatggcccctgtgtggttccctttaccttggcttcct ggcccagtccctgcctctccacctgcaccctgcttcctnggcccagtcccaggttggagt ccctctgcatagctgactactcatgcattg c nnnnnnnnnnnnnnnnnnnnnnnnnnnnc aacaccaaacgtggttgccacatttcatcagacagacacctccctctggagatgcagttg agtgacaaccttgttacattgtagcctagaccaattctgtgtggatatttaagtgaacat gtttacaatttttgtatatatcactctctccctctcctgaaagaccagagattgtgtatt ttcagtgtcccatgttccgactgc > 40322 at HG-U95Av2 113- 98677.doc 200533758 ttgctgtctgatctttgtagactgttcctgtttgctgggagcttctctgctgcttaaatt gttcgtcctcccccactccctcctatc gttggtttgtctagaacactcagctgcttcttt ggtcatccttgttttctaactttatgaactccctctgtgtcactgtatgtga > 40333_at HG-U95Av2 agcatcactcacagcgggccaggaagaagaanaagnactgccggcgcnactcgctctatg tggactnnnnnnnnnnnnnnnnnnnnnnnnctnggattntnggccccaccaggctaccag gccttctactgccatggggactgcccctttccactggctgaccacctcaactcaaccaac catgccattgtgcagaccctggtcaattctgtcaattccagtatccccaaagcctgttgt nnnnnnnnnnnnnnnnnnnncatctccatgctgtacctggatgagtatgataaggtggta ctgaaaaattatcaggagatggtagtagagggatgtgggtgccgctgagatcaggcagtc cttgaggatagacagatatacacaccacacacacacaccacatacaccacacacacacgt tcccatccactcacccacacactacacagactgcttccttatagctggacttttatttna aaaaaaaaaaaaaaaanggaaaaaatccctaaacattcaccttgaccttatttatgactt tacgtgc > 40362_at HG-U95Av2 tgtcacttggtgatacagctctgcagaacctggagcagctgctagacgggccagaagccc agggcagctgggcagagctggcagagcgtctggggctgcgcagcctggtagacacgtacc

gacagacaacctcacccagtggcagcctcctgcgcagctacgagctggctggcggggacc tggcaggtctactggaggccctgtctgacatgggcctagaggagggagtgaggctgctga ggggtccagaaacccgagacaagctgcccagcacagaggtgaaggaagacagtgcgtacg ggagccagtcagtggagcaggaggcagagaagctgggcccaccccctgagccaccaggag ggctctcgcacgggcacccccagcctcaggtgactgacctgctgcctgcccccagccccc ttcccggaccccctgtacagcgtccccacctatttcaaatcttatttaacaccccacacc cacccctcagttgggacaaataaaggat >40367_atHG-U95Av2 gtgtctccaagagacatgttaggataagcaggtctttgcaccaagatgaacacagctggt cacagataaggccattgctagtaacttttggccatgatggaaaagggcatcctctccaca aaagagaaaaacgtcaagccaaacacaaacagcggnaacngnnttaagtccagctgtaag agacaccctttgtacgtggacttcagtgacgtggggtggaatgactggattgtggctccc ccggggtatcacgccttttactgccacggagaatgcccttttcctctggctgatcatctg aactccactaatcatgccattgttcagacgttggtcaactctgttaactctaagattcct aaggcatgctgtgtcccgacagnnnnnnnnnnnnnnnnnnnnnnntaccttgacgagaat gaaaaggttgtattaaagaactatcaggacatggttgtggagggttgtgggtgtcgctag tacagcaaaattaa >40370_f_at HG-U95AV2 atcatactgacctggcagcgggatggggaggaccagacccaggacgtggagctcgtggag accaggcctgcaggggatggaaccttccagaagtgggcagctgtggtggtgccttctgga gaggagcagagatacacgtgccatgtgcagcatgaggggctgccggagcccctcatgctg agatggaagcagtcttccctgcccaccatccccatcatgggtatcgttgctggcctggtt gtccttgcagctgtagtcactggagctgcggtcgctgctgtgctgtggagnaagaagagc tcagattgaaaaggagggagcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnngtggcaagtccctttgtgacttcaagaaccctgacttctctttctgcagagacc agcccacccctgtgcccaccatgaccctcttcctcatgctgaactgcattccttccccaa tcacctttcctgttccagaaaaggggctgggatgtctccgtctctgtctcaaa >40385_at HG-U95Av2 aggctgtgacatcaatgctatcatctttcacacaaagaaaaagttgtctgtgtgcgcaaa tccaaaacagacttgggtgaaatatattgtgcgtctcctcagtaaaaaagtcaagaacat gtaaaaactgtggcttttctggaatggaattggacatagcccaagaacagaaagaacctt gctggggttggaggtttcacttgcacatcatggagggtttagtgcttatctaatttgtgc ctcactggacttgtccaattaatgaagttgattcatattgcatcatagtttgctttgttt aagcatcacattaaagttaaactgtattttatgttatttatagctgtaggttttctgtgt ttagctatttaatactaattttccataagctattttggtttagtgcaaagtataaaatta tatttgggggggaataagattatatggactttcttgcaagcaacaagctattttttaaaa aaaactatttaacattcttttgtttatattgttttgtctcctaaattgttgtaattgc >40391 at HG-U95Av2 114- 98677.doc 200533758 tactttgtttacctcggtgcttacaacagaatgctgccctacatcgtcatgggtagtctg actgtcctgattggaatcctcaccctttttttccctgaaagtttgggaatgactctnnnn nnnnnnnnnnnnnagatgcagaaagtgaaatggttnannnnnnnnnannnnnnaaaaaaa caagagactcaatgna gnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnntgaaaaacagaaaaataagaccctgtggagaaattcgt tgttcccactgaaatggactgactgtaacgattgacaccaaaatgaaccttgctatcaag aaatgctcgtcatacagtaaactctggatgattcttccagat >40393_at HG-U95Av2 gtgtggatacctgagaaggactacttggtatcaaatacttttgagatggctacagtcage tagctggacagcccatgctgactggggacatacacttgcatctttgttgaaagcagaaga agacagaccctttccccaccttccttacctcctcttcccccattaaggcagctcatccaa gcttgtatttaactgaataaatgagtagacattgtggacctcacaagattattt >4 03 98__s_at HG-U95Av2 atttcttcctgattgacaacagtgttagacaaggtgcaaagcgaaactggttgctcaagt tgatagaaaac >40399_r_at HG-U95AV2gacagacaacctcacccagtggcagcctcctgcgcagctacgagctggctggcggggacc tggcaggtctactggaggccctgtctgacatgggcctagaggagggagtgaggctgctga ggggtccagaaacccgagacaagctgcccagcacagaggtgaaggaagacagtgcgtacg ggagccagtcagtggagcaggaggcagagaagctgggcccaccccctgagccaccaggag ggctctcgcacgggcacccccagcctcaggtgactgacctgctgcctgcccccagccccc ttcccggaccccctgtacagcgtccccacctatttcaaatcttatttaacaccccacacc cacccctcagttgggacaaataaaggat > atcatactgacctggcagcgggatggggaggaccagacccaggacgtggagctcg 40370_f_at HG-U95AV2; 40367_atHG-U95Av2 gtgtctccaagagacatgttaggataagcaggtctttgcaccaagatgaacacagctggt cacagataaggccattgctagtaacttttggccatgatggaaaagggcatcctctccaca aaagagaaaaacgtcaagccaaacacaaacagcggnaacngnnttaagtccagctgtaag agacaccctttgtacgtggacttcagtgacgtggggtggaatgactggattgtggctccc ccggggtatcacgccttttactgccacggagaatgcccttttcctctggctgatcatctg aactccactaatcatgccattgttcagacgttggtcaactctgttaactctaagattcct aaggcatgctgtgtcccgacagnnnnnnnnnnnnnnnnnnnnnnntaccttgacgagaat gaaaaggttgtattaaagaactatcaggacatggttgtggagggttgtgggtgtcgctag tacagcaaaattaa & gt tggag accaggcctgcaggggatggaaccttccagaagtgggcagctgtggtggtgccttctgga gaggagcagagatacacgtgccatgtgcagcatgaggggctgccggagcccctcatgctg agatggaagcagtcttccctgcccaccatccccatcatgggtatcgttgctggcctggtt gtccttgcagctgtagtcactggagctgcggtcgctgctgtgctgtggagnaagaagagc tcagattgaaaaggagggagcnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnngtggcaagtccctttgtgacttcaagaaccctgacttctctttctgcagagacc agcccacccctgtgcccaccatgaccctcttcctcatgctgaactgcattccttccccaa tcacctttcctgttccagaaaaggggctgggatgtctccgtctctgtctcaaa > 40385_at HG-U95Av2 aggctgtgacatcaatgctatcatctttcacacaaagaaaaagttgtctgtgtgcgcaaa tccaaaacagacttgggtgaaatatattgtgcgtctcctcagtaaaaaagtcaagaacat gtaaaaactgtggcttttctggaatggaattggacatagcccaagaacagaaagaacctt gctggggttggaggtttcacttgcacatcatggagggtttagtgcttatctaatttgtgc ctcactggacttgtccaattaatgaagttgattcatattgcatcatagtttgctttgttt aagcatcacattaaagttaaactgtattttatgttatttatagctgtaggttttctgtgt ttagctatttaatactaattttccataagctattttggtttagtgcaaagtataaaatta tatttgggggggaataagattatatggactttcttgcaagcaacaagctattttttaaaa aa aactatttaacattcttttgtttatattgttttgtctcctaaattgttgtaattgc > 40391 at HG-U95Av2 114- 98677.doc 200533758 tactttgtttacctcggtgcttacaacagaatgctgccctacatcgtcatgggtagtctg actgtcctgattggaatcctcaccctttttttccctgaaagtttgggaatgactctnnnn nnnnnnnnnnnnnagatgcagaaagtgaaatggttnannnnnnnnnannnnnnaaaaaaa caagagactcaatgna gnnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnntgaaaaacagaaaaataagaccctgtggagaaattcgt tgttcccactgaaatggactgactgtaacgattgacaccaaaatgaaccttgctatcaag aaatgctcgtcatacagtaaactctggatgattcttccagat > 40393_at HG-U95Av2 gtgtggatacctgagaaggactacttggtatcaaatacttttgagatggctacagtcage tagctggacagcccatgctgactggggacatacacttgcatctttgttgaaagcagaaga agacagaccctttccccaccttccttacctcctcttcccccattaaggcagctcatccaa gcttgtatttaactgaataaatgagtagacattgtggacctcacaagattattt > 4 03 98__s_at HG-U95Av2 atttcttcctgattgacaacagtgttagacaaggtgcaaagcgaaactggttgctcaagt tgatagaaaac > 40399_r_at HG-U95AV2

acaatcagtatgtgcttacctgtgttcaagtagagaaaaatacagtagagtctgatagga catattcttgtaccacagacaaaacaaatcttatgttgcatttactatcaactgctgcta atacgttattataaaacttacctagctcctgaattcttcctatcttatagcttaaa >40427一at HG-U95Av2 catagctgcttttggcgcgaaagatgccgggtctggttgactcaaaccctgccccgcctg agtctcaggagannnnnnnnnnnnnnnnnnnnnnnnnttgcccggagaccaagaaggcgc ncgatgcgtgtatcatcgagaaaggagaagaacactgtggacatctaattgaggcccaca aggaatgcatgagagccct >40434_at HG-U95Av2 agaattgctactcgaaggtgccagaatgacacaaaggacagaattcctttcccagttgtt accctagcaaggctagggagggcatgaacacaaacatannnannnnnnnnnnnnctacac tntctntnaatnanttnngnnnnnnangtnannnaannnttnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnggaacttactccaacaggactgagggaccaagg aaacatgatgggggaggcagagagggcaagagtaaaactgtagcatagcttttgtcacgg tcactagctgatccctcaggtctgctgcaaacacagcatggaggacacagatgactcttt ggtgttggtctttttgtctgcagtgaatgttcaacagtttgcccaggaactgggggatca tatatgtcttagtggacaggggtctgaagtacact >40493_at HG-U95Av2 agagaccctgagttcccactcagacccactcagccaaanntctcatggaagaccnaggan gggcagcactgnntttttgnnttttttgtttttngttttttttttttnngnacactgtcc aaaggttttccatcctgtcctggaatcagagttggaagctgaggagcttcagcctctttt atggtttaatggccacctgttctctcctgtgaaaggctttgcaaagtcacattaagtttg catgacctgttatccctggggccctatttcatagaggctggccctattagtgatttccaa aaacaatatggaagtgccttttgatgtcttacaataagaataacatggtccattcacctt tatgttatagatatgtctttgtgtaaatcatttgttttgagttttcaaagaatagcccat tgttcattcttgtg >40496_at HG-U95Av2 tacaggatcccaatgacaagaccaanttctacgcagctggcctggtgtcctgggggcccc agtgtgggacctatgggctctacacacgggtaaagaactatgttgactggataatgaaga ctatgcaggaaaatagcaccccccgtgaggactaatccagatacatcccaccagcctctc caagggtggtgaccaatgcattaccttctgttccttatgatattctcattatttcatcat gactgaaagaagacacgagcgaatgatttaaatagaacttgattgttgagacgccttgct agaggtagagtttgatcatagaattgtgctggtcatacatttgtggtctgactccttggg gtcctttccccggagtacctattgtagataacactatgggtggggcactcctttcttgca ctattccacagggataccttaattctttgtttcctctttacctgttcaaaattccattta cttgatcattctcagtatccactgtctatgtacaataaagg >40505 at HG-U95Av2 115 - 98677.doc 200533758 tccccctagggctcaggcactgaggngcctggggacagtggagcatatgggtgggagaca gatggagggtaccctatttacaactgagtcagccaagccactgatgggaatatacagatt taggtgctaaaccntttattttccacggatgagtcacaatctgaagaatcaaacttccat cctgaaaatctatatgtttcaaaaccacttgccatcctgttagattgccagttcctgggn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnannnnnnaaaaaaaaaaaaaann nnnnnnnnannnannannanattgagggcctccaggacttggcaagtcttggtnnnnnnn nnnnnnnnnnnnnnnnnnnngatgggcaggcaaatctgtccgttctc >40511_at HG-U95AV2 ccgttcaccagttgccattgagggtttcagagagcctttttctaggcctacatgctttgt gaacaagtccctgtaattgttgtttgtatgtataattcaaagcaccaaaataagaaaaga tgtagatttatttcatcatattatacagaccgaactgttgtataaatttatttactgcta gtcttaagaactgctttctttcgtttgtttgtttcaatattttccttctctctcaatttt tggttgaataaactagattacnattcagttggcctaaggtggttgtgctcggagggtttc ttgtttcttttccattttgtttttggatgatatttattaaatagcttctaagagtccggc ggcatctgtcttgtccctattcctgcagcctgtgctgagggtagcagtgtatgagctnnn nnnnnnnnnnnnnnnnnnnnnnnnncgacaggccacgtcctgcaatcggcccggctgcct cttcgccctgtcgtgttctgtacaatcagtatgtgcttacctgtgttcaagtagagaaaaatacagtagagtctgatagga catattcttgtaccacagacaaaacaaatcttatgttgcatttactatcaactgctgcta atacgttattataaaacttacctagctcctgaattcttcctatcttatagcttaaa > 40427 a at HG-U95Av2 catagctgcttttggcgcgaaagatgccgggtctggttgactcaaaccctgccccgcctg agtctcaggagannnnnnnnnnnnnnnnnnnnnnnnnttgcccggagaccaagaaggcgc ncgatgcgtgtatcatcgagaaaggagaagaacactgtggacatctaattgaggcccaca aggaatgcatgagagccct > 40434_at HG-U95Av2 agaattgctactcgaaggtgccagaatgacacaaaggacagaattcctttcccagttgtt accctagcaaggctagggagggcatgaacacaaacatannnannnnnnnnnnnnctacac tntctntnaatnanttnngnnnnnnangtnannnaannnttnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnggaacttactccaacaggactgagggaccaagg aaacatgatgggggaggcagagagggcaagagtaaaactgtagcatagcttttgtcacgg tcactagctgatccctcaggtctgctgcaaacacagcatggaggacacagatgactcttt ggtgttggtctttttgtctgcagtgaatgttcaacagtttgcccaggaactgggggatca tatatgtcttagtggacaggggtctgaagtacact > 40493_at HG-U95Av2 agagaccctgagttcccactcagacccactcagccaaanntctcatggaagaccnaggan gggcagcactgnntttttgnntt ttttgtttttngttttttttttttnngnacactgtcc aaaggttttccatcctgtcctggaatcagagttggaagctgaggagcttcagcctctttt atggtttaatggccacctgttctctcctgtgaaaggctttgcaaagtcacattaagtttg catgacctgttatccctggggccctatttcatagaggctggccctattagtgatttccaa aaacaatatggaagtgccttttgatgtcttacaataagaataacatggtccattcacctt tatgttatagatatgtctttgtgtaaatcatttgttttgagttttcaaagaatagcccat tgttcattcttgtg > 40496_at HG-U95Av2 tacaggatcccaatgacaagaccaanttctacgcagctggcctggtgtcctgggggcccc agtgtgggacctatgggctctacacacgggtaaagaactatgttgactggataatgaaga ctatgcaggaaaatagcaccccccgtgaggactaatccagatacatcccaccagcctctc caagggtggtgaccaatgcattaccttctgttccttatgatattctcattatttcatcat gactgaaagaagacacgagcgaatgatttaaatagaacttgattgttgagacgccttgct agaggtagagtttgatcatagaattgtgctggtcatacatttgtggtctgactccttggg gtcctttccccggagtacctattgtagataacactatgggtggggcactcctttcttgca ctattccacagggataccttaattctttgtttcctctttacctgttcaaaattccattta cttgatcattctcagtatccactgtctatgtacaataaagg > 40505 at HG-U95Av2 115 - 98677.doc 200533758 tccccctagggctcaggcactgaggngcctggggacagtg gagcatatgggtgggagaca gatggagggtaccctatttacaactgagtcagccaagccactgatgggaatatacagatt taggtgctaaaccntttattttccacggatgagtcacaatctgaagaatcaaacttccat cctgaaaatctatatgtttcaaaaccacttgccatcctgttagattgccagttcctgggn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnannnnnnaaaaaaaaaaaaaann nnnnnnnnannnannannanattgagggcctccaggacttggcaagtcttggtnnnnnnn nnnnnnnnnnnnnnnnnnnngatgggcaggcaaatctgtccgttctc > 40511_at HG-U95AV2 ccgttcaccagttgccattgagggtttcagagagcctttttctaggcctacatgctttgt gaacaagtccctgtaattgttgtttgtatgtataattcaaagcaccaaaataagaaaaga tgtagatttatttcatcatattatacagaccgaactgttgtataaatttatttactgcta gtcttaagaactgctttctttcgtttgtttgtttcaatattttccttctctctcaatttt tggttgaataaactagattacnattcagttggcctaaggtggttgtgctcggagggtttc ttgtttcttttccattttgtttttggatgatatttattaaatagcttctaagagtccggc ggcatctgtcttgtccctattcctgcagcctgtgctgagggtagcagtgtatgagctnnn nnnnnnnnnnnnnnnnnnnnnnnnncgacaggccacgtcctgcaatcggcccggctgcct cttcgccctgtcgtgttctgt

>40568_at HG-U95Av2 cacatgattacaattgccagtagagttgttgtttggggtacaagatgagaagaaagaaaa acctacagcctttctacattctgacatgctaacagtggtttaagtttctaaagtgttnnn nnnnnnnnnnnngncaaggggagggagcagaagcacttatgtttacggatattttaaact ctgttagagagcagcctttgaaaatccccaatttggttctgctttttgacctctctctac cttttcagggtaatctttgtg gnnnnnnnnnnnnnnnnnnnnangc 111 nnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnngnccctgagcgatcttctatgcagttctgccatgcg tcctgttggtctctctgtgttctttgttacttgggtgcaatagcaacttccctaccccgt gcattccatctttcatgttgtgtaaagttcttca >40604_at HG-U95Av2 atggtttgacttattcttcgtatcattagaagaaccccagagatagcattcctctatttt attttactttcttttggattgcactgattgtttttgtgggaatgacactttatctggcaa agtaactgagagtttggtaaaagaatattttcttctctgaataataattattttcacagt gaaaatttcagtattttatcactaatgtatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc tgcctgtttggaca ataggttttgggtagtacagattaggataagtaagcttatatatgcacagagattattgt attacctgtaaattgatttacaagtacttaaaagcgtggtccccagtgaggccaaga >40606_at HG-U95AV2 tcgtctcctatgagcaacgccagaattataaggatgacttcaatgcagagtatgatgagt acagagctttgcatgccaggatggagactgtagctagaagatttatcaaactagatgcac aaagaaannnnnnnnnnnnnnnntcaaaagagtatcagaatgttcatgaagaagtcttac aagaatatcagaagataaagcagtctagtcccaattaccatgaagaaaaatacagatgtg aatatcttcataacaagctggctcacatcaaaaggctaataggtgaatttgaccaacagc aagcagagtcatggtcctagaactctgcttggaccagaagatgtgaataaacttaagctt atttatttaaaattcnnaannannnnnnnnanantctaaaaaggtgaaactttggctgtt gaaagtttcagtattagtaaacttngagttactttttcttttccattttactttgcttcc ctgcatttcggaag >40626_at HG-U95Av2 ctgtgttccctcttggaacctgaccnnnnatgctagaagaacccttggaaaacatgctgg cccagccctctagttttacaaataagggagtgcacagccctgagaggttacatggcctgc ccaagatcacgcagtcaatggcagagtaaagagcatagcctaggcctccccactcctcta gtaatgctctttcatcttctccaacctggctctaagccttgtccatcctgagccccatat ctagcccaacctagtccctgaaaacaagaagtggcccttagaaatctctctccagtccca ctatcagaggccaactgctgtcttccagtctccttcagcctgtgctcctctccctccctg actgacaggcagaaggtacngtgcctctggatatccccacagtgccctgagctgcatctc ttgcngactgctttaatacatcacagtgacattgtgtgtgtctctgccac >40648 at HG-U95Av2 116- 98677.doc 200533758 atccaattgtacctgatgtttttggtatttgtcttccttaccaagtgaactccatggccc caaagcaccagatgaatgttgttaagtaagctgtcattaaaaatacataatatatattta tttaaagagaaaaaatatgtgtatatcatggaaaaagacaaggatattttaataaaacat tacttatttcatttcacttatcttgcatatcttaaaattaagcttcagctgctccttgat attaacatttgtacagagttgaagttgttttttcaagttcttttctttttcatgactatt aaatgtaaaaatatttgtaaaatgaaatgccatatttgacttggcttctggtcttgatgt atttgataagaatgattcattcaatgtttaaagttgtataactgattaattttctgatat ggcttcctaataaaatatgaataaggaannanaaaaanaannnannnnanacttgaaaga cagtggtcggcagcggccttgtggcctttgcaaaggaattcccttaatgcctggtccttg gggcaattgctctgaccattcttggcattgctttatagagatatggaaaaaccacaccag ggtct >40670_at HG-U95Av2 tgctggtgccttcattcatgaaaagcatgcccatacgattaaacctgcgagatcggagtt ctttaattaggaatggaatgcaacagatttggacaagtcaaggacaagnnntttnnnnnn nnnnannnnnttntcnctgntannnnnnncagtatgtagccgagaaccatatggagaaca tcaaatacagtggaacaaatgtaactgctattgatgtcacactttgtgaagtagtctttg ttgcttaaaaagggtgacatctagtggctaaacattcgtctcctatgagcaacgccagaattataaggatgacttc 40606_at HG-U95AV2; > 40568_at HG-U95Av2 cacatgattacaattgccagtagagttgttgtttggggtacaagatgagaagaaagaaaa acctacagcctttctacattctgacatgctaacagtggtttaagtttctaaagtgttnnn nnnnnnnnnnnngncaaggggagggagcagaagcacttatgtttacggatattttaaact ctgttagagagcagcctttgaaaatccccaatttggttctgctttttgacctctctctac cttttcagggtaatctttgtg gnnnnnnnnnnnnnnnnnnnnangc 111 nnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnngnccctgagcgatcttctatgcagttctgccatgcg tcctgttggtctctctgtgttctttgttacttgggtgcaatagcaacttccctaccccgt gcattccatctttcatgttgtgtaaagttcttca > 40604_at HG-U95Av2 atggtttgacttattcttcgtatcattagaagaaccccagagatagcattcctctatttt attttactttcttttggattgcactgattgtttttgtgggaatgacactttatctggcaa agtaactgagagtttggtaaaagaatattttcttctctgaataataattattttcacagt gaaaatttcagtattttatcactaatgtatnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnc tgcctgtttggaca ataggttttgggtagtacagattaggataagtaagcttatatatgcacagagattattgt attacctgtaaattgatttacaagtacttaaaagcgtggtccccagtgaggccaaga & gt aatgcagagtatgatgagt acagagctttgcatgccaggatggagactgtagctagaagatttatcaaactagatgcac aaagaaannnnnnnnnnnnnnnntcaaaagagtatcagaatgttcatgaagaagtcttac aagaatatcagaagataaagcagtctagtcccaattaccatgaagaaaaatacagatgtg aatatcttcataacaagctggctcacatcaaaaggctaataggtgaatttgaccaacagc aagcagagtcatggtcctagaactctgcttggaccagaagatgtgaataaacttaagctt atttatttaaaattcnnaannannnnnnnnanantctaaaaaggtgaaactttggctgtt gaaagtttcagtattagtaaacttngagttactttttcttttccattttactttgcttcc ctgcatttcggaag > 40626_at HG-U95Av2 ctgtgttccctcttggaacctgaccnnnnatgctagaagaacccttggaaaacatgctgg cccagccctctagttttacaaataagggagtgcacagccctgagaggttacatggcctgc ccaagatcacgcagtcaatggcagagtaaagagcatagcctaggcctccccactcctcta gtaatgctctttcatcttctccaacctggctctaagccttgtccatcctgagccccatat ctagcccaacctagtccctgaaaacaagaagtggcccttagaaatctctctccagtccca ctatcagaggccaactgctgtcttccagtctccttcagcctgtgctcctctccctccctg actgacaggcagaaggtacngtgcctctggatatccccacagtgccctgagctgcatctc ttgcngactgctttaatacatcacagtgacattgtgtgtgtctctgccac > 40648 at HG-U95Av2 116- 98677.doc 200533758 atccaattgtacctgatgtttttggtatttgtcttccttaccaagtgaactccatggccc caaagcaccagatgaatgttgttaagtaagctgtcattaaaaatacataatatatattta tttaaagagaaaaaatatgtgtatatcatggaaaaagacaaggatattttaataaaacat tacttatttcatttcacttatcttgcatatcttaaaattaagcttcagctgctccttgat attaacatttgtacagagttgaagttgttttttcaagttcttttctttttcatgactatt aaatgtaaaaatatttgtaaaatgaaatgccatatttgacttggcttctggtcttgatgt atttgataagaatgattcattcaatgtttaaagttgtataactgattaattttctgatat ggcttcctaataaaatatgaataaggaannanaaaaanaannnannnnanacttgaaaga cagtggtcggcagcggccttgtggcctttgcaaaggaattcccttaatgcctggtccttg gggcaattgctctgaccattcttggcattgctttatagagatatggaaaaaccacaccag ggtct > 40670_at HG-U95Av2 tgctggtgccttcattcatgaaaagcatgcccatacgattaaacctgcgagatcggagtt ctttaattaggaatggaatgcaacagatttggacaagtcaaggacaagnnntttnnnnnn nnnnannnnnttntcnctgntannnnnnncagtatgtagccgagaaccatatggagaaca tcaaatacagtggaacaaatgtaactgctattgatgtcacactttgtgaagtagtctttg ttgcttaaaaagggtgacatctagtggctaaacat

>40671_g_at HG-U95Av2 gactcaattgcagtgatcctgttcagtggggtgcatttttacannnnnnnnnnnnnnnnn nnnnnnnnnnnnnnaaaannnggacaagcgaagggttgttatgttggctttgatctagca catgcagttggaaatgttgaactctacttacatgactggggagttgattttgcctgctgg tgttcctacaagta >40672_at HG-U95Av2 cagcaccagatttaagatggataacaaactgcagttaatccctggggtctgtggattccg aatttcaaatcctcccattttgttggtctgttccttgcatgcta >40687一at HG-U95Av2 aaggctctgcagagatgactgggctggggaagcagatgcttgctggccatggannnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnacagacagnntcagcatggaatgctcttggcca agggtactgggggccctctggccttttgcagctgatccagaggaacccagagccaactta ccccaacctcacccta nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn acaggaaaaggcggattgaggctgctgggtcagccttgatngcacagacagagcttgtgc cggatttggccctgtcaaggggactggtgccttgttttcatcactccttcctagttctac tgttcaagcttctgaaataaacaggacttgatcacaaanannnnnnnannnannnnnnnn nnnnnnnnnnngggttgggggatagagttattttgcccaggcttcctttacttcttggtc ctgta >40698_at HG-U95Av2 tcaaaacgctgattaaaagaagcacggtatgatgaccaaacataaaaagtgttttataat tgttggtgttttaataacaactaatattattactctgatagttaaactaactcgagattc tcagagtttatgcccctatgattggattggtttccaaaacaaatgctattatttctctaa agaagaaggagattggaattcaagtaaatacaactgttccactcaacatgccgacctaac tataattgacaacatagaagaaatgaattttcttaggcggtataaatgcagttctgatca ctggattggactgaagatggcaaaaaatcgaacaggacaatgggtagatggagctacatt taccaaatcgtttggcatgagagggagtgaaggatgtnnnnnnnnnnnnnnngatggtgc agcaacagctagatgttacaccgaaagaaa >406_at HG-U95AV2 acgtgccctacaagttcaaggtgcaggccaggaccactgagggcttcgggccagagcgcg agggcatcatcaccatagagtcccaggatggaggacccttcccgcagctgggcagccgtg ccgggctcttccagcacccgctgcaaagcgagtacagcagcatcaccaccacccacacca gcgccaccgagcccttcctagtggatgggctgaccctgggggcccagcacctggaggcag gcggctccctcacccggcatgtgacccaggagtttgtgagccggacactgaccaccagcg gaacccttagcacccacatggaccaacagttcttccaaacttgaccgcaccctgccccac ccccgccatgtcccactaggcgtcctcccgactcctctcccggagcctcctcagctactc catccttgcacccctgggggcccagcccacccgcatgcacagagcaggggctaggtgtct cctgggaggcatgaagggggcaaggtccgtcctctgtgggcccaaacctatttgtaacca -117- 98677.doc 200533758 aagagctgggagcagcaca >40823_s_at HG_U95Av2 gacagcactcaactcaagcacaaagtacgggccaggggggtctttctgcaccttcatcct taatatgtcacagtttgtgtgatnnnnnnnnnnnnnnncctgatggggcaactgtgagca ttaaacctgaaccagaagatcgagagcctaactttgcaaccattggtctgcaggacatca ctttagat >4 08 99_at HG-U95Av2 cacacggagcagctccagatgagcaggtccgaggttacntgacctgcggcgcacccttca gggtcttgagattgagctgcagtcacagctgagcatgaaagctgccttggaagacacact ggcagaaacggaggcgcgctttggagccnnnnnnnggcgcatatccangcgctgatnann nnnnnnnnnnnnnnnnnnggncgatgtgcgagctgatagtgnnnnnnnnnnnnnnnnnnn nnnnnngctcatggacatcaagtcgcggctggagcaggagattgccacctaccgcagcct gctcgagggacaggaagatcactacaacaatttgtctgcctccaaggtcctctgaggcag caggct >408_at HG-U95AV2 attaactctacctgcacactgtcctattatattcattctttttgaaatgtcaaccccaagtcaaaacgctgattaaaagaagcacggtatgatgaccaaacata 40698_at HG-U95Av2; > 40671_g_at HG-U95Av2 gactcaattgcagtgatcctgttcagtggggtgcatttttacannnnnnnnnnnnnnnnn nnnnnnnnnnnnnnaaaannnggacaagcgaagggttgttatgttggctttgatctagca catgcagttggaaatgttgaactctacttacatgactggggagttgattttgcctgctgg tgttcctacaagta > 40672_at HG-U95Av2 cagcaccagatttaagatggataacaaactgcagttaatccctggggtctgtggattccg aatttcaaatcctcccattttgttggtctgttccttgcatgcta > 40687 a at HG-U95Av2 aaggctctgcagagatgactgggctggggaagcagatgcttgctggccatggannnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnacagacagnntcagcatggaatgctcttggcca agggtactgggggccctctggccttttgcagctgatccagaggaacccagagccaactta ccccaacctcacccta nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn acaggaaaaggcggattgaggctgctgggtcagccttgatngcacagacagagcttgtgc cggatttggccctgtcaaggggactggtgccttgttttcatcactccttcctagttctac tgttcaagcttctgaaataaacaggacttgatcacaaanannnnnnnannnannnnnnnn nnnnnnnnnnngggttgggggatagagttattttgcccaggcttcctttacttcttggtc ctgta & gt aaaagtgttttataat tgttggtgttttaataacaactaatattattactctgatagttaaactaactcgagattc tcagagtttatgcccctatgattggattggtttccaaaacaaatgctattatttctctaa agaagaaggagattggaattcaagtaaatacaactgttccactcaacatgccgacctaac tataattgacaacatagaagaaatgaattttcttaggcggtataaatgcagttctgatca ctggattggactgaagatggcaaaaaatcgaacaggacaatgggtagatggagctacatt taccaaatcgtttggcatgagagggagtgaaggatgtnnnnnnnnnnnnnnngatggtgc agcaacagctagatgttacaccgaaagaaa > 406_at HG-U95AV2 acgtgccctacaagttcaaggtgcaggccaggaccactgagggcttcgggccagagcgcg agggcatcatcaccatagagtcccaggatggaggacccttcccgcagctgggcagccgtg ccgggctcttccagcacccgctgcaaagcgagtacagcagcatcaccaccacccacacca gcgccaccgagcccttcctagtggatgggctgaccctgggggcccagcacctggaggcag gcggctccctcacccggcatgtgacccaggagtttgtgagccggacactgaccaccagcg gaacccttagcacccacatggaccaacagttcttccaaacttgaccgcaccctgccccac ccccgccatgtcccactaggcgtcctcccgactcctctcccggagcctcctcagctactc catccttgcacccctgggggcccagcccacccgcatgcacagagcaggggctaggtgtct cctgggaggcatgaagggggcaaggtccgtcctctgtgggcccaaacctatttgtaacca -117- 98677.doc 200533758 aagagctgggagcagcaca > 40823_s_at HG_U95Av2 gacagcactcaactcaagcacaaagtacgggccaggggggtctttctgcaccttcatcct taatatgtcacagtttgtgtgatnnnnnnnnnnnnnnncctgatggggcaactgtgagca ttaaacctgaaccagaagatcgagagcctaactttgcaaccattggtctgcaggacatca ctttagat > 4 08 99_at HG-U95Av2 cacacggagcagctccagatgagcaggtccgaggttacntgacctgcggcgcacccttca gggtcttgagattgagctgcagtcacagctgagcatgaaagctgccttggaagacacact ggcagaaacggaggcgcgctttggagccnnnnnnnggcgcatatccangcgctgatnann nnnnnnnnnnnnnnnnnnggncgatgtgcgagctgatagtgnnnnnnnnnnnnnnnnnnn nnnnnngctcatggacatcaagtcgcggctggagcaggagattgccacctaccgcagcct gctcgagggacaggaagatcactacaacaatttgtctgcctccaaggtcctctgaggcag caggct > 408_at HG-U95AV2 attaactctacctgcacactgtcctattatattcattctttttgaaatgtcaaccccaag

ttagttcaatctggattcatatttaatttgaaggtagaatgttttcaaatgttctccagt cattatgttaatatttctgaggagcctgcaacatgccagccactgtgatagaggctggcg gatccaagcaaatggccaatgagatcattgtgaaggcaggggaatgtatgtgcacatctg ttttgtaactgtttagatgaatgtcagttgttatttattgaaatgatttcacagtgtgtg gtcaacatttctcatgttgaaactttaagaactaaaatgttctaaatatcccttggacat tttatgtctttcttgtaaggcatactgccttgtttaatggtagttttacagtgtttctgg cttagaacaaaggggctta >41048_at HG-U95Av2 ggaacagttagttctcatctagaatgaaagttccatatatgcattggtgaatatatatgt atacacatacttacatacttatatgggtatctgtatagataatntgtattagagtattat atagcttcttagtagggtctcaagtaagnttcattttttttatctgggctatatacagtc ctcaaataaataatgtcttgattttatttcagcaggaataattttatttattttgcctat ttataattaaagtatttttctttagtttgaaaatgtgtattaaagttacatttttgagtt acaagagtcttataactacttgaatttttagttaaaatgtcttaatgtaggttgtagtca ctttagatggaaaattacctcacatctgttttcttcagtattacttaagattgtttattt agtggtagagagntttttttttcagcctagaggcagctattttaccatctggtatttatg gtctaatttgtatttaaacatatgcacacatataaaagttgatactg >41140_at HG-U95Av2 agctgctagagttctgtctggactttccagagaccagtattcccttttgctgcctctaaa aggcctgtccctgcagacatgagagacagcaggtctcatgggggtgacaagctttttttt ttttncttaaagaattttcaaaatcaaattccagaatgattttacggagatatcccagga aaattaaggcttctcttaaacactaaaaaggcatgtaattgcttgttagcaaaatggata tgacacatctctgatacttttttcattattggttgggctgagcagtcagaagacctggtc gtcgtcttgacttt gnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnagggacacngagtggcccttcatgtacatccatggtgtgctggcttaaaat >41168_at HG-U95AV2 gagaacccgtactctagggccaaatccattcttcttgccctggctcacttgtccccccca ccgccccgcgctggagccactgcctagttcttcagccctagatggtgctcgccagacctc ctctcaatgctcatcacacacagggctattcctttcctccaatgaaccaaacgcctcccg cccacctccaggtcccagtcctctgttccctttgcctggtccacccttgccctccctggg tcgcaganganggtcggcctcgtcanttccccgcagaccgccgcgcgtccctcttgtgcg gttcaccacagttgtatttaagtgatcgtgtgagtcgtcgttaaatgcctgtctccccgc ggatcatgggctcctngaggnnnnnnnnnnnnnnnnnnnnnnnnnnnnntaaccccgcgc cggcatagggacctaaggcccactggagggcgctcatcaagtagctgctggatgttgacg aaggaagcggcggcgcagctcagggatctccgagtcaggacggtcggccaganccacggg gtaacgggtctaatcgtgtaggaataaagctgtattccagtgcttc >41171_at HG-U95Av2 tagcaatccaggagaaggtgctggagagggtgaatgccgtcaagaccaaagtggaagctt 118 - 98677.doc 200533758 tccagacaaccatttccaagtacttctcagaacgtggggatgctgtngccaaggcctcca aggagactcatgtaatggattaccgggccttggtgcatgagcgagatgaggcagcctatg gggagctcagggccatggtgctggacctgagggccttctatgctgagctttatcatatca tcagcagcaacctggagaaaattgtcaacccaaagggtgaagaaaagccatctatgtact gaacccgggactagaaggaaaataaatgatctatatgttgtgtggaaaaaaaaaaaaaaa aaaanaannnnaannnnnnnnnnnnnnnnnnnnnnncctgaagatgaatgtggtgggaag gggtgggtgtcacaaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna agaggggattcaggccctttctcatccagtag >41184_s_at HG-U95Av2 ctatgggcagtatgatctgtggctgggataagaagggtccnnnnnnnnnnnnnnnnnnnn nnnnnnngactcggctctcaggaaatatgttctccacgggtagtgggaacacttatgcct acggggtcatggacagtggctatcggcctaatcttagccctgaagaggcctatgaccttg gccgcagggctattgcttatgccactcacagagacagctattctggaggcgttgtcaata tgtaccacatgaaggaagatggttgggtgaaagtagaaagtacagatgtcagtgacctgc tgcaccagtaccgggaagccaatcaataatggtggtggtggcagctgggcaggtctcctc tgggaggtcttggccga >41191_at HG-U95Av2ttagttcaatctggattcatatttaatttgaaggtagaatgttttcaaatgttctccagt cattatgttaatatttctgaggagcctgcaacatgccagccactgtgatagaggctggcg gatccaagcaaatggccaatgagatcattgtgaaggcaggggaatgtatgtgcacatctg ttttgtaactgtttagatgaatgtcagttgttatttattgaaatgatttcacagtgtgtg gtcaacatttctcatgttgaaactttaagaactaaaatgttctaaatatcccttggacat tttatgtctttcttgtaaggcatactgccttgtttaatggtagttttacagtgtttctgg cttagaacaaaggggctta > 41048_at HG-U95Av2 ggaacagttagttctcatctagaatgaaagttccatatatgcattggtgaatatatatgt atacacatacttacatacttatatgggtatctgtatagataatntgtattagagtattat atagcttcttagtagggtctcaagtaagnttcattttttttatctgggctatatacagtc ctcaaataaataatgtcttgattttatttcagcaggaataattttatttattttgcctat ttataattaaagtatttttctttagtttgaaaatgtgtattaaagttacatttttgagtt acaagagtcttataactacttgaatttttagttaaaatgtcttaatgtaggttgtagtca ctttagatggaaaattacctcacatctgttttcttcagtattacttaagattgtttattt agtggtagagagntttttttttcagcctagaggcagctattttaccatctggtatttatg gtctaatttgtatttaaacatatgcacacatataaaagttgatactg > 41140_at HG-U95Av2 agctgctagagttctgtctggactttccagag accagtattcccttttgctgcctctaaa aggcctgtccctgcagacatgagagacagcaggtctcatgggggtgacaagctttttttt ttttncttaaagaattttcaaaatcaaattccagaatgattttacggagatatcccagga aaattaaggcttctcttaaacactaaaaaggcatgtaattgcttgttagcaaaatggata tgacacatctctgatacttttttcattattggttgggctgagcagtcagaagacctggtc gtcgtcttgacttt gnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnagggacacngagtggcccttcatgtacatccatggtgtgctggcttaaaat > 41168_at HG-U95AV2 gagaacccgtactctagggccaaatccattcttcttgccctggctcacttgtccccccca ccgccccgcgctggagccactgcctagttcttcagccctagatggtgctcgccagacctc ctctcaatgctcatcacacacagggctattcctttcctccaatgaaccaaacgcctcccg cccacctccaggtcccagtcctctgttccctttgcctggtccacccttgccctccctggg tcgcaganganggtcggcctcgtcanttccccgcagaccgccgcgcgtccctcttgtgcg gttcaccacagttgtatttaagtgatcgtgtgagtcgtcgttaaatgcctgtctccccgc ggatcatgggctcctngaggnnnnnnnnnnnnnnnnnnnnnnnnnnnnntaaccccgcgc cggcatagggacctaaggcccactggagggcgctcatcaagtagctgctggatgttgacg aaggaagcggcggcgcagctcagggatctccgagtcaggacggtcggccaganccacggg gtaacgggtctaatcgtgtaggaataaagctgtattcc agtgcttc > 41171_at HG-U95Av2 tagcaatccaggagaaggtgctggagagggtgaatgccgtcaagaccaaagtggaagctt 118 - 98677.doc 200533758 tccagacaaccatttccaagtacttctcagaacgtggggatgctgtngccaaggcctcca aggagactcatgtaatggattaccgggccttggtgcatgagcgagatgaggcagcctatg gggagctcagggccatggtgctggacctgagggccttctatgctgagctttatcatatca tcagcagcaacctggagaaaattgtcaacccaaagggtgaagaaaagccatctatgtact gaacccgggactagaaggaaaataaatgatctatatgttgtgtggaaaaaaaaaaaaaaa aaaanaannnnaannnnnnnnnnnnnnnnnnnnnnncctgaagatgaatgtggtgggaag gggtgggtgtcacaaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna agaggggattcaggccctttctcatccagtag > 41184_s_at HG-U95Av2 ctatgggcagtatgatctgtggctgggataagaagggtccnnnnnnnnnnnnnnnnnnnn nnnnnnngactcggctctcaggaaatatgttctccacgggtagtgggaacacttatgcct acggggtcatggacagtggctatcggcctaatcttagccctgaagaggcctatgaccttg gccgcagggctattgcttatgccactcacagagacagctattctggaggcgttgtcaata tgtaccacatgaaggaagatggttgggtgaaagtagaaagtacagatgtcagtgacctgc tgcaccagtaccgggaagccaatcaataatggtggtggtggcagctgggcaggtctcctc tgggaggtcttggccga > 41191_at HG-U95Av2

ggcctctcttagctcagttactcaattcatacgtagtattttttaaaataattttatatc tgtgtaccaccccatatatttcatattactgtttcacatgtacagctttctacttctttg taagaacancaaccaaccaannnnggtttaannnnnnnnnnnnnnnnnnnnnnnngggtg gcagatgttctatgcagtgtggttcaagtttctttgaccgcacttatatgcattgctaat atggaatttaagataccatacacagtctctcatggacctatctctattgtagaattatga cttatgtcttacttgncaaatttttctgaatgtgacctttttttgctgatttgctgggtt tgggattaactagcattattttgccacctttatattgtatttataaaaaaaaagtactat caatcaatcatactactttggattgttg >41237_at HG-U95Av2 cctgactttgtttctgcaaaggcacctgcatgtgtctgtgttcntgtaggcataatgtga ggaggtggggagaccaccccacccccatgtccaccatgaccctcttcccacgctgacctg tgctccctccccaatcatctttcctgttccagagaggtggggctgaggtgtctccatctc tgnctcaacttcatggtgcactgagetgtaacttnttccttccctattaaaattagaacc tgagtataaatttactttctcaaattcttgccatgagaggt >412 39__r__at HG-U95Av2 tttgcaaatctcaggataaagtttgctaagtaaattagtaatgtactatagatataactg tacaaaaattgttcaacctaaaacaatctgtaattgcttattgttttattgtatactctt tgtctttttaagacccctaatagccttttgtaacttgatggcttaaaaatacttaataaa tctgccatttca >412 66__at HG-U95Av2 agtctcagtttcttgcttggggaacttgtgtccctaatgtgtttagattgctagattgct aaggagctgatactttgacagtgtttttagacctgtgttactaaaaaaaagatgaatgtc ctgaaaagggtgttgggagggtggttcaacaaagaaacaaagatgttatggtgtttagat ttatggttgttaaaaatgtcatctcaagtcaagtcactggtctgtttgcatttgatacat >41294__at HG-U95Av2 gtgaatatctctgtgatgaattccactggtggcagtagcagtggcggtggcattgggctg accctcgggggaaccatgggcagcaatgccntgagcttctccagcagtgcgggtcnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaggagtncccgcgactga gccgcctcccaccactccactcctccagccaccanccacaatcacannnnnnnnnnnnnc cnttgccgaggctgaggagtgtggggagctggnnnnnaagnatncncgngccnngcagga ggnagctggaagcngccctgcagcgggccaagcaggatatggcacggcagctgcgtgagt accaggaactcatgagcgtgaagctggccctggacatcgagatcgccacctaccgcaagc tgctggagggcgaggagagccggttggctggnagatggnagtgggnagccgtgaatatct ctgtgatgaattc >41352_at HG-U95Av2 gttctgatttgacacactgattttaatcttcgaatcatgacactgagtgcagaggaggtg gcattccgacagcaggacatacatgttggtgtgaagactgggacgacactgggtagaatc 119- 98677.doc 200533758 tagtttttaattattattaatataaaggatcaaattaatttaaatatgattctgaagtct acagaacttttagttctgtgctgtctatgtggacactttggtaaaatgcaaattatgata tggacgttatcattggtctggtgagatgtttcatatttgtgacagttaatttaaaaatta tganttaatgctgcctgtgtctatggggttctgtcttctttgatagccatctattcatct ggatcatgggaccctctctaatccttccaccaatcaaataagctattgctattggtttgg agttgagatatcagtctcggaaactt >41362_at HG-U95Av2 cacaactggggcagaatttaaagctgcaacacagctggtgatgagaggctncctcagtcc agtcgctccttagncnccaggcaccgtgggnccnggatggggaactgcaagcannctctc agctgatggctgcncagtncagatgtctggtggcagagagtccgangcatggagcgattc cattttatgactgttgtttttcacattttcatctttctaaggtgtgtcncttttncnann nnnannnnnttttnnnannccaaaagtcgatcaatcgcattcattttaagaaattatacc tttttagtacttgctgaagaatgat nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna t agacagcacttgtgaaggattgaa tgcaggttccaggtggagggaagacgtggannnnnnnnnnnnnnnnncatgcagacattt ttaaaagctatacaaaaaattgtgagaagacattggccaactctttcaaagtcggcctctcttagctcagttactcaattcatacgtagtattttttaaaataattttatatc tgtgtaccaccccatatatttcatattactgtttcacatgtacagctttctacttctttg taagaacancaaccaaccaannnnggtttaannnnnnnnnnnnnnnnnnnnnnnngggtg gcagatgttctatgcagtgtggttcaagtttctttgaccgcacttatatgcattgctaat atggaatttaagataccatacacagtctctcatggacctatctctattgtagaattatga cttatgtcttacttgncaaatttttctgaatgtgacctttttttgctgatttgctgggtt tgggattaactagcattattttgccacctttatattgtatttataaaaaaaaagtactat caatcaatcatactactttggattgttg > 41237_at HG-U95Av2 cctgactttgtttctgcaaaggcacctgcatgtgtctgtgttcntgtaggcataatgtga ggaggtggggagaccaccccacccccatgtccaccatgaccctcttcccacgctgacctg tgctccctccccaatcatctttcctgttccagagaggtggggctgaggtgtctccatctc tgnctcaacttcatggtgcactgagetgtaacttnttccttccctattaaaattagaacc tgagtataaatttactttctcaaattcttgccatgagaggt > 412 39__r__at HG-U95Av2 tttgcaaatctcaggataaagtttgctaagtaaattagtaatgtactatagatataactg tacaaaaattgttcaacctaaaacaatctgtaattgcttattgttttattgtatactctt tgtctttttaagacccctaatagccttttgtaacttgatggcttaaaaatacttaataaa tctgccatttca > 412 66_ _at HG-U95Av2 agtctcagtttcttgcttggggaacttgtgtccctaatgtgtttagattgctagattgct aaggagctgatactttgacagtgtttttagacctgtgttactaaaaaaaagatgaatgtc ctgaaaagggtgttgggagggtggttcaacaaagaaacaaagatgttatggtgtttagat ttatggttgttaaaaatgtcatctcaagtcaagtcactggtctgtttgcatttgatacat > 41294__at HG-U95Av2 gtgaatatctctgtgatgaattccactggtggcagtagcagtggcggtggcattgggctg accctcgggggaaccatgggcagcaatgccntgagcttctccagcagtgcgggtcnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaggagtncccgcgactga gccgcctcccaccactccactcctccagccaccanccacaatcacannnnnnnnnnnnnc cnttgccgaggctgaggagtgtggggagctggnnnnnaagnatncncgngccnngcagga ggnagctggaagcngccctgcagcgggccaagcaggatatggcacggcagctgcgtgagt accaggaactcatgagcgtgaagctggccctggacatcgagatcgccacctaccgcaagc tgctggagggcgaggagagccggttggctggnagatggnagtgggnagccgtgaatatct ctgtgatgaattc > 41352_at HG-U95Av2 gttctgatttgacacactgattttaatcttcgaatcatgacactgagtgcagaggaggtg gcattccgacagcaggacatacatgttggtgtgaagactgggacgacactgggtagaatc 119- 98677.doc 200533758 tagtttttaattattattaatataaaggatcaaattaatttaaata tgattctgaagtct acagaacttttagttctgtgctgtctatgtggacactttggtaaaatgcaaattatgata tggacgttatcattggtctggtgagatgtttcatatttgtgacagttaatttaaaaatta tganttaatgctgcctgtgtctatggggttctgtcttctttgatagccatctattcatct ggatcatgggaccctctctaatccttccaccaatcaaataagctattgctattggtttgg agttgagatatcagtctcggaaactt > 41362_at HG-U95Av2 cacaactggggcagaatttaaagctgcaacacagctggtgatgagaggctncctcagtcc agtcgctccttagncnccaggcaccgtgggnccnggatggggaactgcaagcannctctc agctgatggctgcncagtncagatgtctggtggcagagagtccgangcatggagcgattc cattttatgactgttgtttttcacattttcatctttctaaggtgtgtcncttttncnann nnnannnnnttttnnnannccaaaagtcgatcaatcgcattcattttaagaaattatacc tttttagtacttgctgaagaatgat nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnna t agacagcacttgtgaaggattgaa tgcaggttccaggtggagggaagacgtggannnnnnnnnnnnnnnnncatgcagacattt ttaaaagctatacaaaaaattgtgagaagacattggccaactctttcaaagtc

>41384_at HG-U95Av2 ttcttgtttataacagtgccttaaggtatgatgtatttctgatggaagccattttcacat tcatgttcttcatggattatttgttacttgtctaagatgcaatttgattttatgaagtat ataccctttacccaccagagacagtacagaatccctnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngttattaatttaaaactccattattaggattacattttaaagttttatt tatgaattccctttaaaaatgatatttcaaaggtaaaacaatacaatataaagaaaaaaa taaatatattaataccggcnnnnnnnnnccatttttaacctcagccttccctactgtcac caacaaccaagctaaataaagtcaacagcctgatgtg >41419一at HG-U95Av2 ctcattggaattttcttcaagtgttaaaggtacattttcactaggaaaagaaatcaaata tgcttatgcaatatatatttgtgtgtttttccttaatgttatatggtatatatgagcctt cttgtttagtttcttttatctgctaagttgtaccttaattagagggcaatatatgtttca taaagaagagtctttataantttgtttgtcagatagtatttnggaanttgtataataagg atgtttagaagccatataagtggctttttttaacagatagaatttgtatttttattgtac tttaaaaagatttatgtaataggtatatatttagtggccatttattatcaatggtaacac aatggagtactaagatggtatttgcacatttaagatatgttactttaccaatttttaatg gtaatcaactctgctactggcatgatgaaatagtacataactggtcattaattatgaaca tttanttctccagtgcgtttttatgaagatctggttgaaaattgtatttctatgtaaact caacgatatgtttggttttcctg >41433一at HG-U95Av2 caaagtaaaacttgctgcctgaagancagtanctnccatcangatgagagaactggagga gttccttgatctgtatatacaataacataatttgtacatatgtaaaataaaattatgcca tagcaagattgcttaaaatagcaacactctatatttagattgttaaaataactagtgttg cttggactattataatttaatgcatgttaggaaaatttcacattaatattnnnnnnnnnn nnnnntttgtcatctttcttctattttattccctttcacaaaattttattcctatatagt ttattgacaataatttcaggttttgtaaagatgccgggttttatatttttatagacaaat aataagcaaagggagcactgggttgactttcaggtactaaatacctcaacctatggtata atgg >41439_at HG-U95Av2 ctgtttctggtaaataccatatatgatcctcgaaatgataatatctccannnnnnnnnnn nnnnncaaatttgagtagatattttaaacacctaacaaagtaaagggctaaaagccattc agatagcagtaaaacattctgtatgatgtgcdataaaacatccaagatcttttttgaaag ttttatttataatatacatttttgtatgagaaaggtgattggtacagggtgcctatttta gtcatggatcaaaatttgtgtaacttgcagggctttctttctttttcttcaaatttacaa gggttcattttggaaactacattttaaactttggaatcaaattgtttcttatttgggagg ataatgtatatacattggtattatgttaaataataaaattgttctaatttggtgccannn nnnnaaaaaaaaannnnanntttgnatctcaagctattttcatatgttatgtgtcaatgt atcatctctcagaaaggttttacaatccaaacattatatgttctctgtgtaactgaattt cacttatcttttataaaccagaaacattaattgaaaanannttctggggattttctcttg acttgta 120- 98677.doc 200533758 >41446_f_at HG-U95Av2 ctggtgtctcctgcacctgcgctggttcctgcaagtgcaaagagtgcaaatgcacctcct gcaagaagagctgctgctcctgnctnncccgtgggntgtagcaagtgtgcccagggctgt gtttgcaaaggggcgtcagagaagtgcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nncagatgtaaacagagagacatgtacaaacctggnnnttttttttttataccaccttga cccatttgctacattccttttcctgtgaaatatgtgag >41475一at HG-U95Av2 ggaccagcccttgctctgactgcggccaagcaccacgcaggaggccactcttgtctctca gcagctgttcccaggnggnagctccctnctnggcacatgggggctggncacaatagccca gagggtcagaactggacagctgcagagacctgtgcccagagaanggtctcgacccactca aggacacacagcaggtccgtggatgggctggatgagtgaccagggccagcctctgtctca ggacattccagaaggacaaggagatgtctctccctctcccaaagcaccagcgtccctgcc tcccgtgggccctgtccgggttgccctggtgaccccagcctctgtccacttcctaaccca gggaccctgcacagccagaactncctttggccctacggatggccactggctctggtctaa agtgcctgggcttggtggccatcaagagggagccagtcaggcctgtgagggccgtagacc ttgtatataccctgcaccagcagtgaccgggcagagcc≫ 41384_at HG-U95Av2 ttcttgtttataacagtgccttaaggtatgatgtatttctgatggaagccattttcacat tcatgttcttcatggattatttgttacttgtctaagatgcaatttgattttatgaagtat ataccctttacccaccagagacagtacagaatccctnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngttattaatttaaaactccattattaggattacattttaaagttttatt tatgaattccctttaaaaatgatatttcaaaggtaaaacaatacaatataaagaaaaaaa taaatatattaataccggcnnnnnnnnnccatttttaacctcagccttccctactgtcac caacaaccaagctaaataaagtcaacagcctgatgtg > 41419 a at HG-U95Av2 ctcattggaattttcttcaagtgttaaaggtacattttcactaggaaaagaaatcaaata tgcttatgcaatatatatttgtgtgtttttccttaatgttatatggtatatatgagcctt cttgtttagtttcttttatctgctaagttgtaccttaattagagggcaatatatgtttca taaagaagagtctttataantttgtttgtcagatagtatttnggaanttgtataataagg atgtttagaagccatataagtggctttttttaacagatagaatttgtatttttattgtac tttaaaaagatttatgtaataggtatatatttagtggccatttattatcaatggtaacac aatggagtactaagatggtatttgcacatttaagatatgttactttaccaatttttaatg gtaatcaactctgctactggcatgatgaaatagtacataactggtcattaattatgaaca tttanttctccagtgcgtttttatgaagatctggttgaaaattgtatttctatgtaaact caacgatatgtttggttttcctg > 41433 a at HG-U95Av2 caaagtaaaacttgctgcctgaagancagtanctnccatcangatgagagaactggagga gttccttgatctgtatatacaataacataatttgtacatatgtaaaataaaattatgcca tagcaagattgcttaaaatagcaacactctatatttagattgttaaaataactagtgttg cttggactattataatttaatgcatgttaggaaaatttcacattaatattnnnnnnnnnn nnnnntttgtcatctttcttctattttattccctttcacaaaattttattcctatatagt ttattgacaataatttcaggttttgtaaagatgccgggttttatatttttatagacaaat aataagcaaagggagcactgggttgactttcaggtactaaatacctcaacctatggtata atgg > 41439_at HG-U95Av2 ctgtttctggtaaataccatatatgatcctcgaaatgataatatctccannnnnnnnnnn nnnnncaaatttgagtagatattttaaacacctaacaaagtaaagggctaaaagccattc agatagcagtaaaacattctgtatgatgtgcdataaaacatccaagatcttttttgaaag ttttatttataatatacatttttgtatgagaaaggtgattggtacagggtgcctatttta gtcatggatcaaaatttgtgtaacttgcagggctttctttctttttcttcaaatttacaa gggttcattttggaaactacattttaaactttggaatcaaattgtttcttatttgggagg ataatgtatatacattggtattatgttaaataataaaattgttctaatttggtgccannn nnnnaaaaaaaaannnnanntttgnatctcaagctattttcatatgttatgtgtcaatgt atcatct ctcagaaaggttttacaatccaaacattatatgttctctgtgtaactgaattt cacttatcttttataaaccagaaacattaattgaaaanannttctggggattttctcttg acttgta 120- 98677.doc 200533758 > 41446_f_at HG-U95Av2 ctggtgtctcctgcacctgcgctggttcctgcaagtgcaaagagtgcaaatgcacctcct gcaagaagagctgctgctcctgnctnncccgtgggntgtagcaagtgtgcccagggctgt gtttgcaaaggggcgtcagagaagtgcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nncagatgtaaacagagagacatgtacaaacctggnnnttttttttttataccaccttga cccatttgctacattccttttcctgtgaaatatgtgag > 41475 a at HG-U95Av2 ggaccagcccttgctctgactgcggccaagcaccacgcaggaggccactcttgtctctca gcagctgttcccaggnggnagctccctnctnggcacatgggggctggncacaatagccca gagggtcagaactggacagctgcagagacctgtgcccagagaanggtctcgacccactca aggacacacagcaggtccgtggatgggctggatgagtgaccagggccagcctctgtctca ggacattccagaaggacaaggagatgtctctccctctcccaaagcaccagcgtccctgcc tcccgtgggccctgtccgggttgccctggtgaccccagcctctgtccacttcctaaccca gggaccctgcacagccagaactncctttggccctacggatggccactggctctggtctaa agtgcctgggcttggtggccatcaagagggagccagtcaggcctgtgagggccgtagacc ttgtatataccctgcaccagcagtgaccggg cagagcc

>41534_at HG-U95Av2 catccatacattactgtgtttggctgaattccactctaatatgatgctccnattatgcac catactgtgatgacctttctactccgaaacctgctggagcctnccnttggccgtggggtg tcagccaatcactgcttgttccacttgttgtacattttatttttgagtctttttctttct catatacagaaaaatagtatgaaaataaaataaatgtatgaaacagtattaatgcagaaa tgtgctactaatggatgtctgagtcaccagaaattccattcttaaagaggcggttagcac ctattagacgtaacagtgatgtcttttaaaaaatccaaaagcatattgcaacaataagtt tgagactttgtgtgaacaaagggaaattcagcctcttatgtctttg >41554__at HG-U95Av2 gtccacagttattcaaacaatggctttttttgtgatgagagtatttgttaaaaaaaaaaa aaagacttcaagaaaaataaaagttcagtggagctgcaaataaatctggtgaataatttc atctttggtaatctcccatttcctgagttcttcctcaatccaagctgtcctgtgtagtat ataacatttgggcattttctctgatatactatactctcatgttctataaatttctgtccc gtaattctaacactttacattttttctttgctatcagctatagctattcatggaagggaa gaatcactaaatacttgtctagttatagnnnnnnnnnnnnnnntcctccttatccctcga tgcctggcttggtgtctggcaaacagtccataattagcagatgttgaaagaccgtttaca aagcagaatttggggatttaaagtgcaatgatacaacaaaaagatttaattacagcttcc agtgttttgactatgtgaaccat >41592_at HG-U95Av2 agctgtgccgccagcgcatcgtggccaccgtgggccgcgagaacctggctcgcatccccc tcaaccccgtcctccgcgactacctgagntnc nnnnc nnnn c nnnnnnnnnnnnnnnnnn ccgccgtgcacgcagcattaactgggatgccgtgttattttgttattacttgcctggaac catgtgggtaccctccccggcctgggttggagggagcggatgggtgtaggggcgaggcgc ntcccgccctcggctggagacgaggccgcagaccccttctcacctcttgagggggtcctc cccctcctggtgctccctctgggtccccctggttgttgtagcagcttaactgtatctgga gccaggacctgaactcgcacctcctacctcttcatgtttacatatacccagtatctttgc acaaaccaggggtt >41601一at HG-U95Av2 gacccacaagcagatatttgaattacttcttnnnnnnnnnnnnnnnnnnnnnggatgggc tgcatttactgtgtgaaggataaaaatcattagcctggattctgatttctataaattgcc attaaaagctttttttcccctaagaactgaaatgtgctcaccagccaaaacattttaact tgtaaattttgagggcagttaaccaaacctgtgactaatcatatctcctcctacccccca tttccaaggacatttgttactcagatacttgttatactaatacttgaacttgtaccttat ggtatttgctatcttttaactagteatgatattcttatactttagttacacttttggaat ttgatacaaggttgagtggggtgtgtgggtgtatgtatgagtgaaacagttctcaaaaga atgtaagaaaaaccatttttataaaattgtgactttttaaaaacatagtctttgtcattt atagaattaacaagctgctcagggtatattttatagctgtagcactgatatc >41612 at HG-U95AV2 121 - 98677.doc 200533758 atcttgttttacactcccatgggtccttcaggctctcatcttttttctttttccagtcta ttttcnnnnnnnnnnnnnnnnnttaatttttattgaccttccatggtcctcactgattgt tttctttgtcanacctaanctgttgnagtttgtgncagtgagttttncattttggttttg tattttnccagttgtttnaatttnccattgggtgggttcttttgtnacaccttctgtttc tttgncttattttttaacgnccaaagaaagactctcagagaatagacaactatattccaa agtcatggttctctggtggtttgtcttgacatttgaatagaaatgttaaactatctgggg gaatagaaagcccacagtcttctgagttgtgctacaccaatatttctatgaacagatctt acaactgagagtgatctgcagatttttcagagtcatgttctcc >41635_at HG-U95Av2 gctctatattacttgcttgagccttaatcaatgtggttttattcaatggtttgttctttg aatggttgcaaaaactgtagataatcttactgaggactgtacaaacatgaaggtgtggta tcaaacttcaggnnnnnnnnnnnnnnnnnattataaacattcatttcacaactagattgt ataaggatattagctgtgatgagactcactgcattattttttttagtgaattttatgaaa tccccgttccattcaacaggcacatgtttaaaagagctttgtcgttggtgttaatggggg aatgtgttccttcattgtatttgggccttttgtattgcactcttgat >41654_at HG-U95Av2agctg 41592_at HG-U95Av2; > 41534_at HG-U95Av2 catccatacattactgtgtttggctgaattccactctaatatgatgctccnattatgcac catactgtgatgacctttctactccgaaacctgctggagcctnccnttggccgtggggtg tcagccaatcactgcttgttccacttgttgtacattttatttttgagtctttttctttct catatacagaaaaatagtatgaaaataaaataaatgtatgaaacagtattaatgcagaaa tgtgctactaatggatgtctgagtcaccagaaattccattcttaaagaggcggttagcac ctattagacgtaacagtgatgtcttttaaaaaatccaaaagcatattgcaacaataagtt tgagactttgtgtgaacaaagggaaattcagcctcttatgtctttg > 41554__at HG-U95Av2 gtccacagttattcaaacaatggctttttttgtgatgagagtatttgttaaaaaaaaaaa aaagacttcaagaaaaataaaagttcagtggagctgcaaataaatctggtgaataatttc atctttggtaatctcccatttcctgagttcttcctcaatccaagctgtcctgtgtagtat ataacatttgggcattttctctgatatactatactctcatgttctataaatttctgtccc gtaattctaacactttacattttttctttgctatcagctatagctattcatggaagggaa gaatcactaaatacttgtctagttatagnnnnnnnnnnnnnnntcctccttatccctcga tgcctggcttggtgtctggcaaacagtccataattagcagatgttgaaagaccgtttaca aagcagaatttggggatttaaagtgcaatgatacaacaaaaagatttaattacagcttcc agtgttttgactatgtgaaccat & gt tgccgccagcgcatcgtggccaccgtgggccgcgagaacctggctcgcatccccc tcaaccccgtcctccgcgactacctgagntnc nnnnc nnnn c nnnnnnnnnnnnnnnnnn ccgccgtgcacgcagcattaactgggatgccgtgttattttgttattacttgcctggaac catgtgggtaccctccccggcctgggttggagggagcggatgggtgtaggggcgaggcgc ntcccgccctcggctggagacgaggccgcagaccccttctcacctcttgagggggtcctc cccctcctggtgctccctctgggtccccctggttgttgtagcagcttaactgtatctgga gccaggacctgaactcgcacctcctacctcttcatgtttacatatacccagtatctttgc acaaaccaggggtt > 41601 a at HG-U95Av2 gacccacaagcagatatttgaattacttcttnnnnnnnnnnnnnnnnnnnnnggatgggc tgcatttactgtgtgaaggataaaaatcattagcctggattctgatttctataaattgcc attaaaagctttttttcccctaagaactgaaatgtgctcaccagccaaaacattttaact tgtaaattttgagggcagttaaccaaacctgtgactaatcatatctcctcctacccccca tttccaaggacatttgttactcagatacttgttatactaatacttgaacttgtaccttat ggtatttgctatcttttaactagteatgatattcttatactttagttacacttttggaat ttgatacaaggttgagtggggtgtgtgggtgtatgtatgagtgaaacagttctcaaaaga atgtaagaaaaaccatttttataaaattgtgactttttaaaaacatagtctttgtcattt atagaattaacaagctgctcagggtatattttatagctgtagcact gatatc > 41612 at HG-U95AV2 121 - 98677.doc 200533758 atcttgttttacactcccatgggtccttcaggctctcatcttttttctttttccagtcta ttttcnnnnnnnnnnnnnnnnnttaatttttattgaccttccatggtcctcactgattgt tttctttgtcanacctaanctgttgnagtttgtgncagtgagttttncattttggttttg tattttnccagttgtttnaatttnccattgggtgggttcttttgtnacaccttctgtttc tttgncttattttttaacgnccaaagaaagactctcagagaatagacaactatattccaa agtcatggttctctggtggtttgtcttgacatttgaatagaaatgttaaactatctgggg gaatagaaagcccacagtcttctgagttgtgctacaccaatatttctatgaacagatctt acaactgagagtgatctgcagatttttcagagtcatgttctcc > 41635_at HG-U95Av2 gctctatattacttgcttgagccttaatcaatgtggttttattcaatggtttgttctttg aatggttgcaaaaactgtagataatcttactgaggactgtacaaacatgaaggtgtggta tcaaacttcaggnnnnnnnnnnnnnnnnnattataaacattcatttcacaactagattgt ataaggatattagctgtgatgagactcactgcattattttttttagtgaattttatgaaa tccccgttccattcaacaggcacatgtttaaaagagctttgtcgttggtgttaatggggg aatgtgttccttcattgtatttgggccttttgtattgcactcttgat > 41654_at HG-U95Av2

aaaggctgaacatcaatgcggccaaatctagtttcctcccagaagatgaaaagagggagc ttctcgacctgctctataaagcctatgggatgccaccttcagcctctgcagggcagaacc tctgaagacgccactcctcc nnnnnnnnnnnnnnnnnnnnnnnnnnna c tctgtggggct gagcaacatttttacatttattccttccaagaagaccatgatctcaatagtcagttactg atgctcctgaaccctatgtgtccatttctgcacacacgtatacctcggcatggccgcgtc acttctctgattatgtgccctggccagggaccagcgcccttgcacatgggcatggtt >41656_at HG-U95Av2 tgtacccgcgactaactagacttttctgctgttgtgcaaagttcagtttcttctcagcaa catcaaggatatatgaagaaaaggaaataaaaaactgtaaagtcaaaagagatgcctggt ggaacttattcgtgctatcagggcattgatagtttgaatgtttttattacttatgcaaaa ttgcacatactcctctatnctgattttatcatgaaaactgtcatgtgtcatgctaatgga >41677—atHG-U95Av2 agcaagctcaccaggcctctcagaagtcccagnnnnnnnnnnnnnnnngccgggtcggcg cctcctgcgcgagggagcaggttctccgcattcccatgggcaccacctgcctgcctgtcg tgccttgganncnnnncccngnnnnnnaggagagaccaaaggcttctgagcaggattttt atttcattacagtgtgagctgcctggaatacatgtggtaatgaaataaaaanccctgncc ccgaatcttccgtnccctcatcctaacttncagttcacagagaaaagtgacatacccaaa gctctctgtcaattacaaggcttctcctggcgtgggagacgtctacagggaagacaccag cgtttgggcttctaaccaccctgtctccagctnctctgcacacatggacagggacctggg aaaggtgggagagatgctgagcccagcgaatcctctcnnnnnnnnnnnnnnngaagaaga aaactcaactcagtgccattttacgaatatatgcg >41711_at HG-U95AV2 catcccagtgttatgtaaagatggtgtgcctgagggagcccccacagctggtgctgggcc tgcatttccttggccccaacgcaggcgaagttactnnnnnnnnnnnnnnnnnnnnnnant gnggggcttcctatgcgcaggtgatgcggaccgtgggtatccatcccacatgctctgagg aggtagtcaanntgcgcatctccaagcgctcaggcctggacnnnnnnnnnnnnnnnnnnn nnnnntaagcgccatccctgcaggccnagggcacacggtgcgcccgccgccagctcctcg gaggccagacccaggatggctgcaggccaggtttggggggcctcaaccctctcctggagc gcctgtgagatggtcagegtggagcgcaagtgctggacaggtggcccgtgtgccccacag ggatggctcaggggactgtccacctcacccctgcacctctcagcctctgccgccgggcan ccccccccaggct nnt gg t g c cnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnntccgagccccctggcatttctgcaatgcaaata >41742_s_at HG-U95Av2 gcagtccttgatggagatgcagagtcgtcatggggcgagaacaagtgactctgaccagca ggcttaccttgttcaaagaggagctgaggacagggactggcggcaacagcggaatattcc gattcattcctgccccaagtgtggagaggttctgcctgacatagacacgttacagattca cgtgatggattgc >41743 i at HG-U95Av2 122- 98677.doc 200533758 actggaactggcagagaaggctctggcttccaaacannnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnngcaggaagaggacctggaaaccatgaccatncnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaa a ttcatgaggaa aaggagcaact gnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnaggcaggcagtccttgatggagatgcagagtcgtcatggggcgagaacaagtgactct gaccagcaggcttaccttgttcaaagaggagctgaggacagggactggcggcaacagcgg aatattccgattcattcctgccccaagtgtggagaggttctgcctgacatagacacgtta cagattcacgtgatggattgcatcatttaagtgttgatgtatcacctccccaaaactgtt ggtaaatgtcaga >41816—at HG-U95Av2 tctctcctgtgtaaatgtcacgccccacccctgtttcatgtgggcactaacacgtgtgcg ttcctggcgggcacactcaggaccgtgcctcacagggcccactccctgcctatgcctccc tcttggggggccgaggagggcggctgctctgtcatgagaatgtacggcccgtggatgatt aacgggcctttttcacttagaagctg >41831一at HG-U95Av2 cgtccagcacgaaggccacgctgtacccgccgatcctgaacccgccgccctccccggccaaaaggctgaacatcaatgcggccaaatctagtttcctcccagaagatgaaaagagggagc ttctcgacctgctctataaagcctatgggatgccaccttcagcctctgcagggcagaacc tctgaagacgccactcctcc nnnnnnnnnnnnnnnnnnnnnnnnnnna c tctgtggggct gagcaacatttttacatttattccttccaagaagaccatgatctcaatagtcagttactg atgctcctgaaccctatgtgtccatttctgcacacacgtatacctcggcatggccgcgtc acttctctgattatgtgccctggccagggaccagcgcccttgcacatgggcatggtt > 41656_at HG-U95Av2 tgtacccgcgactaactagacttttctgctgttgtgcaaagttcagtttcttctcagcaa catcaaggatatatgaagaaaaggaaataaaaaactgtaaagtcaaaagagatgcctggt ggaacttattcgtgctatcagggcattgatagtttgaatgtttttattacttatgcaaaa ttgcacatactcctctatnctgattttatcatgaaaactgtcatgtgtcatgctaatgga > 41677-atHG-U95Av2 agcaagctcaccaggcctctcagaagtcccagnnnnnnnnnnnnnnnngccgggtcggcg cctcctgcgcgagggagcaggttctccgcattcccatgggcaccacctgcctgcctgtcg tgccttgganncnnnncccngnnnnnnaggagagaccaaaggcttctgagcaggattttt atttcattacagtgtgagctgcctggaatacatgtggtaatgaaataaaaanccctgncc ccgaatcttccgtnccctcatcctaacttncagttcacagagaaaagtgacatacccaaa gctctctgtcaattacaaggcttctcctggcgtgggag acgtctacagggaagacaccag cgtttgggcttctaaccaccctgtctccagctnctctgcacacatggacagggacctggg aaaggtgggagagatgctgagcccagcgaatcctctcnnnnnnnnnnnnnnngaagaaga aaactcaactcagtgccattttacgaatatatgcg > 41711_at HG-U95AV2 catcccagtgttatgtaaagatggtgtgcctgagggagcccccacagctggtgctgggcc tgcatttccttggccccaacgcaggcgaagttactnnnnnnnnnnnnnnnnnnnnnnant gnggggcttcctatgcgcaggtgatgcggaccgtgggtatccatcccacatgctctgagg aggtagtcaanntgcgcatctccaagcgctcaggcctggacnnnnnnnnnnnnnnnnnnn nnnnntaagcgccatccctgcaggccnagggcacacggtgcgcccgccgccagctcctcg gaggccagacccaggatggctgcaggccaggtttggggggcctcaaccctctcctggagc gcctgtgagatggtcagegtggagcgcaagtgctggacaggtggcccgtgtgccccacag ggatggctcaggggactgtccacctcacccctgcacctctcagcctctgccgccgggcan ccccccccaggct nnt gg t g c cnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnntccgagccccctggcatttctgcaatgcaaata > 41742_s_at HG-U95Av2 gcagtccttgatggagatgcagagtcgtcatggggcgagaacaagtgactctgaccagca ggcttaccttgttcaaagaggagctgaggacagggactggcggcaacagcggaatattcc gattcattcctgccccaagtgtggagaggttctgcctgacatagacacgttac agattca cgtgatggattgc > 41743 i at HG-U95Av2 122- 98677.doc 200533758 actggaactggcagagaaggctctggcttccaaacannnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnngcaggaagaggacctggaaaccatgaccatncnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaa a ttcatgaggaa aaggagcaact gnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnaggcaggcagtccttgatggagatgcagagtcgtcatggggcgagaacaagtgactct gaccagcaggcttaccttgttcaaagaggagctgaggacagggactggcggcaacagcgg aatattccgattcattcctgccccaagtgtggagaggttctgcctgacatagacacgtta cagattcacgtgatggattgcatcatttaagtgttgatgtatcacctccccaaaactgtt ggtaaatgtcaga > 41816-at HG-U95Av2 tctctcctgtgtaaatgtcacgccccacccctgtttcatgtgggcactaacacgtgtgcg ttcctggcgggcacactcaggaccgtgcctcacagggcccactccctgcctatgcctccc tcttggggggccgaggagggcggctgctctgtcatgagaatgtacggcccgtggatgatt aacgggcctttttcacttagaagctg > 41831 at HG-U95Av2 cgtccagcacgaaggccacgctgtacccgccgatcctgaacccgccgccctccccggcca a

cggacccctccctgtacaacatggacatgttctactcttcaaacattccggccactgcga gaccgtacaggccctacatcattcgaggaatggcgcccccgacgacgccctgcagcaccg acgtgtgtgacagcgactacagcgccagccgctggaaggccagcaagtactacctggatt tgaactnggactcagacccctatccacccccacccacgccccacagccagtacctgtcgg cggaggacagctgcccgccctcgcccgccaccgagaggagctacttccatctcttcccgc cccctccgtccccctgcacggactcatcctgacctcggccgggccactctggcttctctg tgcccctgtaaatagttttaaat >425_at HG-U95AV2 gctctcacctcatcagcagtgaccagtgtggccaaagtggtcagggtggcctctggctct gccgtagttttgcccctggccaggattgctacagttgtgattggaggagttgtggccatg gcggctgtgcccatggtgctcagtg >4 63__g__at HG-U95Av2 ttgccaaactgcgcaaagatattcgccaggagtatcgagaggactttgtgctcaccgtga ctggcaagaagcacccgtgctgtgtcttatccaatcccgaccagaagggtaagattagga gaatcgactgcctgcgacaggcagacaaagtctggcgtctggatctagtcatggtgatcc tgttcaaaggcatccccttggaaagtaccgatggagagcggctcatgaaatccccacatt gcacaaacccagcactttgtgtccagccacatcatatcacagtatcagttaaggagctt >4 64__s_at HG-U95AV2 gggcctagcagtcttcacctctgagtcaggctaggggcctccccttctcatcctccccac ccccccgccaaggttctcacactggcctgggcttgggtgcccatataggaggtctgtatg ttcaccaacagtgcggaggggtcacacattgcaaaacactgcccagaacagtaaaaagag >481_at HG-U95Av2 gaagacttggccaagaagtattttgctcagatagttcatgctatatcttattgccataaa ctccatgtggttcacag >535_s_at HG-U95AV2 tgatttcaaattgaactcctccattgtggaacccaaggagccagccccagaaacagctga tggcccctacctggtgatcgtggaacagcctaagcagagaggcttccgatttcgatatgg ctgtgaaggcccctcccatggaggactgcccggtgcctccagtgagaagggccgaaagac ctatcccactgtcaagatctgtaactacgagggaccagccaagatcgaggtggacctggt aacacacagtgacccacctcgtgctcatgcccacagtctggtgggcaagcaatgctcgga gctggggatctgcgccgtttctgtggggcccaaggacatgactgcccaatttaacaacct gggtgtcctgcatgtgactaagaagaacatgatggggactatgatacaaaaacttcagag gcagcggctccgctctaggccccagggccttacggaggccgagcagcgggagctggagca agaggccaaagaactgaagaaggtgatggatctgagtatagtgcggctgcgcttctctgc cttccttagagccagtgatggctc >543_g_at HG-U95Av2 gaatatgtcatagttctgagctgccagtggaccgcccttttcccctaccaatattaggtg -123- 98677.doccggacccctccctgtacaacatggacatgttctactcttcaaacattccggccactgcga gaccgtacaggccctacatcattcgaggaatggcgcccccgacgacgccctgcagcaccg acgtgtgtgacagcgactacagcgccagccgctggaaggccagcaagtactacctggatt tgaactnggactcagacccctatccacccccacccacgccccacagccagtacctgtcgg cggaggacagctgcccgccctcgcccgccaccgagaggagctacttccatctcttcccgc cccctccgtccccctgcacggactcatcctgacctcggccgggccactctggcttctctg tgcccctgtaaatagttttaaat > 425_at HG-U95AV2 gctctcacctcatcagcagtgaccagtgtggccaaagtggtcagggtggcctctggctct gccgtagttttgcccctggccaggattgctacagttgtgattggaggagttgtggccatg gcggctgtgcccatggtgctcagtg > 4 63__g__at HG-U95Av2 ttgccaaactgcgcaaagatattcgccaggagtatcgagaggactttgtgctcaccgtga ctggcaagaagcacccgtgctgtgtcttatccaatcccgaccagaagggtaagattagga gaatcgactgcctgcgacaggcagacaaagtctggcgtctggatctagtcatggtgatcc tgttcaaaggcatccccttggaaagtaccgatggagagcggctcatgaaatccccacatt gcacaaacccagcactttgtgtccagccacatcatatcacagtatcagttaaggagctt > 4 64__s_at HG-U95AV2 gggcctagcagtcttcacctctgagtcaggctaggggcctccccttctcatcctccccac ccccccgccaaggttctcacactgg cctgggcttgggtgcccatataggaggtctgtatg ttcaccaacagtgcggaggggtcacacattgcaaaacactgcccagaacagtaaaaagag > 481_at HG-U95Av2 gaagacttggccaagaagtattttgctcagatagttcatgctatatcttattgccataaa ctccatgtggttcacag > 535_s_at HG-U95AV2 tgatttcaaattgaactcctccattgtggaacccaaggagccagccccagaaacagctga tggcccctacctggtgatcgtggaacagcctaagcagagaggcttccgatttcgatatgg ctgtgaaggcccctcccatggaggactgcccggtgcctccagtgagaagggccgaaagac ctatcccactgtcaagatctgtaactacgagggaccagccaagatcgaggtggacctggt aacacacagtgacccacctcgtgctcatgcccacagtctggtgggcaagcaatgctcgga gctggggatctgcgccgtttctgtggggcccaaggacatgactgcccaatttaacaacct gggtgtcctgcatgtgactaagaagaacatgatggggactatgatacaaaaacttcagag gcagcggctccgctctaggccccagggccttacggaggccgagcagcgggagctggagca agaggccaaagaactgaagaaggtgatggatctgagtatagtgcggctgcgcttctctgc cttccttagagccagtgatggctc > 543_g_at HG-U95Av2 gaatatgtcatagttctgagctgccagtggaccgcccttttcccctaccaatattaggtg -123- 98677.doc

200533758 atcccgttttccccatgacaatgttgtagtgtcccccacccccacccccctggccttggt gcctcttgtatccctagtgctgcatagcccggcatttgcacggtttcgaagtcattaaac >544_at HG-U95Av2 ggtgaagaccttgctgctaaatgctgctcagaacaccatggagccacccctgaccccgcc cageccageagggccgggactgtcacttggtgatacagctctgcagaacctggagcagct gctagacgggccagaagcccagggcagctgggcagagctggcagagcgtctggggctgcg cagcctggtagacacgtaccgacagacaacctcacccagtggcagcctcctgcgcagcta c >545_g__at HG-U95Av2 agtggcagcctcctgcgcagctacgagctggctggcggggacctggcaggtctactggag gccctgtctgacatgggcctagaggagggagtgaggctgctgaggggtccagaaacccga gacaagctgcccagcacaacagaggtgaaggaagacagtgcgtacgggagccagtcagtg gagcagaaggcagagaagctgggcccaccccctgagccaccaggagggctctgccacggg cacccccagcctcaggtgcactgacctgctgcctgcccccagcccccttcccggaccccc tgtacagcgtccccacctatttcaaatcttatttaaca200533758 atcccgttttccccatgacaatgttgtagtgtcccccacccccacccccctggccttggt gcctcttgtatccctagtgctgcatagcccggcatttgcacggtttcgaagtcattaaac > 544_at HG-U95Av2 ggtgaagaccttgctgctaaatgctgctcagaacaccatggagccacccctgaccccgcc cageccageagggccgggactgtcacttggtgatacagctctgcagaacctggagcagct gctagacgggccagaagcccagggcagctgggcagagctggcagagcgtctggggctgcg cagcctggtagacacgtaccgacagacaacctcacccagtggcagcctcctgcgcagcta c > 545_g__at HG-U95Av2 agtggcagcctcctgcgcagctacgagctggctggcggggacctggcaggtctactggag gccctgtctgacatgggcctagaggagggagtgaggctgctgaggggtccagaaacccga gacaagctgcccagcacaacagaggtgaaggaagacagtgcgtacgggagccagtcagtg gagcagaaggcagagaagctgggcccaccccctgagccaccaggagggctctgccacggg cacccccagcctcaggtgcactgacctgctgcctgcccccagcccccttcccggaccccc tgtacagcgtccccacctatttcaaatcttatttaaca

>570_at HG-U95AV2 actgacactggactcgtaccaggccccgggccccggggatggaggcaccgccagccttgt gggcagcaacatgttccccaatcattaccgcgaggcggcctttgggggcggcctcctatc cccggggcctgaagccacgtagccccgcgatgccagaggaggggcactgggtggggaggg aggtggaggagccgtgcaatcccaaccaggatgtctagcacccccatccccttggccctt cctcatgcttctgaagtggacatattcagccttggcgagaagctccgttgcacgggtttc cccttgagcccattttacagatgaggaaactgagtccggagaggaaaagggacatggctc ccgtgcactagcttgttacagctgcctctgtccccacatgtgggggcaccttctccagta ggattcggaaaagattgtacatatgggaggagggggcagattcctggccctccctcccca gacttgacttgaaggtggggggtaggttggttgttcagagtcttcccaataaagatgagt ttttgag >574_s_at HG-U95Av2 actctgagcaagtcccagatatactacaactcaatgcaatctttaacatgttgaatacca agaactgcccaagtttgaaggacaaaccgaaggtgatcatcatccaggcctgccgtggtn ncagccctggtgtggtgtggtttaaagattcagtaggagtttctggaaacctatctttac caactacagaagagtttgaggatgatgctattaagaaagcccacatagagaaggatttta tcgctttctgctcttccacaccanntaatgtttcttggagacatcccacaatgggctctg tttttattggaagactcattgaacatatgcaagaatatgcctgttcctgtgatgtggagg aaattttccgcaannttcgattttcatttgagcagccagatggtagagcgcagatgccca c >576_at HG-U95Av2 atcggcgtgctgcgggatcagcaacgctaccacgaagacattttcgggctcacgctgcgc acccaggaggtgacaagccgcatacgcacccagagcttttccttgcaggagcgtcagttg cggggcgcagtgccctgggcgttcgaccctcccggctcagacaccaacagcccctgagag ccgcctggctttcccttccagttccgggagagcggctgcccgactcaggtccgcccgacc aggatcagccccgctcctcccctcttgaggtggtgccttctcacatctgtccagaggctg caaggattcagcattattcctccaggaaggagcaaaacgcctcttttccctctctaggcc tgttgcctcgggcctgggtccgccttaatctggaaggcccctcccagcagcggtacccca gggcctactgccacccgcttcctgtttcttagtccgaatgttagattcctcttgcctctc tcaggagtatcttacctgtaaagtctaatctctaaatcaagtatttattattgaagattt accataagggactgtgccagatgttaggagaactact >583_s_at HG-U95Av2 tgcccatctatgtcccttgctgtgagcaagaagtcaaagtaaaacttgctgcctgaagaa cagtaactgccatcaagatgagagaactggaggagttccttgatctgtatatacaataac ataatttgtacatdtgtsaaataaaattdtgccatagcaagattgcttaaaatagcaaca ctctatatttagattgttaaaataactagtgttgcttggactattataatttaatgcatg ttaggaaaatttcacattaatatttgctgacagctgacctttgtcatctttcttctattt tattccctttcacaaaattttattcctatatagtttattgacaa >590 at HG-U95Av2 124· 98677.doc 200533758 tccgtggcaatgagactctgcactatgagaccttcgggaaggcagcccctgctccgcagg aggccacagccacattcaacagcacggctgacagagaggatggccaccgcaacttctcct gcctggctgtgctggacttgatgtctcgcggtggcaacatctttcacaaacactcagccc cgaagatgttggagatctatgagcctgtgtcggacagccagatggtcatcatagtcacgg tggtgtcggtgttgctgtccctgttcgtgacatctgtcctgctctgcttcatcttcggcc agcacttgcgccagcagcggatggg >595_at HG~U95Av2 aaagccagtaaccatgagtatgaggaaatctctttctgttgctggcttacagtttctctg tgtgctttgtggttgctgtcatatttgctctagaagaaaaaaaaaaaaggaggggaaatg cattttccccagagataaaggctgccattttgggggtctgtacttatggcctgaaaatat ttgtgatccataactctacacagcctttactcatactattaggcacactttccccttaga gccccctaagtttttcccagacgaatctttataatttcctttccaaagataccaaataaa cttcagtgttttcatctaattctcttaaagttgatatcttaatattttgtgttgatcatt atttccattcttaatgtgaaaaaaagtaattatttatacttattataaaaagtatttgaa atttgcacatttaattgtccctaatagaaagccacctattctttgttggatttcttcaag tttttctaaataaatgtaacttttcacaagagtcaac≫ 570_at HG-U95AV2 actgacactggactcgtaccaggccccgggccccggggatggaggcaccgccagccttgt gggcagcaacatgttccccaatcattaccgcgaggcggcctttgggggcggcctcctatc cccggggcctgaagccacgtagccccgcgatgccagaggaggggcactgggtggggaggg aggtggaggagccgtgcaatcccaaccaggatgtctagcacccccatccccttggccctt cctcatgcttctgaagtggacatattcagccttggcgagaagctccgttgcacgggtttc cccttgagcccattttacagatgaggaaactgagtccggagaggaaaagggacatggctc ccgtgcactagcttgttacagctgcctctgtccccacatgtgggggcaccttctccagta ggattcggaaaagattgtacatatgggaggagggggcagattcctggccctccctcccca gacttgacttgaaggtggggggtaggttggttgttcagagtcttcccaataaagatgagt ttttgag > 574_s_at HG-U95Av2 actctgagcaagtcccagatatactacaactcaatgcaatctttaacatgttgaatacca agaactgcccaagtttgaaggacaaaccgaaggtgatcatcatccaggcctgccgtggtn ncagccctggtgtggtgtggtttaaagattcagtaggagtttctggaaacctatctttac caactacagaagagtttgaggatgatgctattaagaaagcccacatagagaaggatttta tcgctttctgctcttccacaccanntaatgtttcttggagacatcccacaatgggctctg tttttattggaagactcattgaacatatgcaagaatatgcctgttcctgtgatgtggagg aaattttccgcaannttcgattttcatttgagc agccagatggtagagcgcagatgccca c > 576_at HG-U95Av2 atcggcgtgctgcgggatcagcaacgctaccacgaagacattttcgggctcacgctgcgc acccaggaggtgacaagccgcatacgcacccagagcttttccttgcaggagcgtcagttg cggggcgcagtgccctgggcgttcgaccctcccggctcagacaccaacagcccctgagag ccgcctggctttcccttccagttccgggagagcggctgcccgactcaggtccgcccgacc aggatcagccccgctcctcccctcttgaggtggtgccttctcacatctgtccagaggctg caaggattcagcattattcctccaggaaggagcaaaacgcctcttttccctctctaggcc tgttgcctcgggcctgggtccgccttaatctggaaggcccctcccagcagcggtacccca gggcctactgccacccgcttcctgtttcttagtccgaatgttagattcctcttgcctctc tcaggagtatcttacctgtaaagtctaatctctaaatcaagtatttattattgaagattt accataagggactgtgccagatgttaggagaactact > 583_s_at HG-U95Av2 tgcccatctatgtcccttgctgtgagcaagaagtcaaagtaaaacttgctgcctgaagaa cagtaactgccatcaagatgagagaactggaggagttccttgatctgtatatacaataac ataatttgtacatdtgtsaaataaaattdtgccatagcaagattgcttaaaatagcaaca ctctatatttagattgttaaaataactagtgttgcttggactattataatttaatgcatg ttaggaaaatttcacattaatatttgctgacagctgacctttgtcatctttcttctattt tattccctttcacaaaattttattcctatatagt ttattgacaa > 590 at HG-U95Av2 124 · 98677.doc 200533758 tccgtggcaatgagactctgcactatgagaccttcgggaaggcagcccctgctccgcagg aggccacagccacattcaacagcacggctgacagagaggatggccaccgcaacttctcct gcctggctgtgctggacttgatgtctcgcggtggcaacatctttcacaaacactcagccc cgaagatgttggagatctatgagcctgtgtcggacagccagatggtcatcatagtcacgg tggtgtcggtgttgctgtccctgttcgtgacatctgtcctgctctgcttcatcttcggcc agcacttgcgccagcagcggatggg > 595_at HG ~ U95Av2 aaagccagtaaccatgagtatgaggaaatctctttctgttgctggcttacagtttctctg tgtgctttgtggttgctgtcatatttgctctagaagaaaaaaaaaaaaggaggggaaatg cattttccccagagataaaggctgccattttgggggtctgtacttatggcctgaaaatat ttgtgatccataactctacacagcctttactcatactattaggcacactttccccttaga gccccctaagtttttcccagacgaatctttataatttcctttccaaagataccaaataaa cttcagtgttttcatctaattctcttaaagttgatatcttaatattttgtgttgatcatt atttccattcttaatgtgaaaaaaagtaattatttatacttattataaaaagtatttgaa atttgcacatttaattgtccctaatagaaagccacctattctttgttggatttcttcaag tttttctaaataaatgtaacttttcacaagagtcaac

>626_s_at HG-U95Av2 cgggctctgctctgatcacctttgatgaccccaaagtggctgagcaggtgctgcaacaaa aggagcacacgatcaacatggaggagtgccggctgcgggtgcaggtccagcccttggagc tgcccatggtcaccaccatccaggtgtccagccagttgagtggccggagggtgttggtca ctggatttcctgccagcctcaggctgagtgaggaggagctgctggacaagctagagatct tctttggcaagactaggaacggaggtggcgatgtggacgttcgggagctactgccaggga gtgtcatgctggggtttgctagggatggagtggctcagcgtctgtgccaaatcggccagt tcacagtgccactgggtgggcagcaagtccctctgagagtctctccgtatgtgaatgggg agatccagaaggctgagatcaggtcgcagccagttccccgctcggtactggtgctcaaca ttcctgatatcttggatggcccggagctgcatgacgtcctggagatccacttccagaagc ccacccgcgggggcggggaggtagaggccctgacagtcgtaccccaag >669_s_at HG-U95Av2 gagaccagtgtatcaggtcagggacttggacaggagtcagtgtctggctttttcctctga gcccagctgcctggagagggtctcgctgtcactggctggctcctaggggaacagaccagt gaccccagaaaagcataacaccaatcccagggctggctctgcactaagagaaaattgcac taaatgaatctcgttcccaaagaactacccccttttcagctgagccctggggactgttcc aaagccagtgaaatgtgaaggaaagtggggtccttcggggcgatgctccctcagcctcag aggagctctaccctgctccctgctttggctgaggggcttgggaaaaaaacttggcacttt ttcgtgtggatcttgccacatttctgatcagaggtgtacactaacatttcccccgagctc ttggcctttgcatttatttatacagtgccttgctcggcgcccaccaccccctcaagcccc agcagccctcaacaggcccagggagggaagtgtgagcgccttggtatgacttaaaattgg >706_at HG-U95Av2 TIGRSequence >712_s_at HG-U95Av2 TIGRSequence >717一at HG-U95Av2 gttcggatttgactgcctgtatatgttttgtgaaatggtcctgtttttgggtaggtgaca cgtggactctagtatgtaaatgttacttgaatctgtgcttcataatagtgtgtggcatgt atgtgcagactcttggatgctttatgcctgcgcaccaggagccctgtcctcacgttccca ggagggcggcttcacccttcgtaaccaggagacaaggcggccatggatttgcccttgatt ctattttgctaatggaagatagaaaggagagaaggtttttttttttttttaacattctga agatggtgctgtgtcaagaaggaccttttttttcccctctcccctattttttaagtacct tggaggaggagaggttggtgacatgcatggtggggatctatggcctctggtgctt >823_at HG-U95Av2 acctgaggggcctcttatgggctgggttctacccaggtgctaggaacactccttcacaga tgggtgcttggaggaaggaaacccagctctggtccatagagagcaaaacgctgtgctgcc ctgcccaccctggcctctgcactcccctgctgggtgtggcgcagcatattcaggaagctc agggccctggctcaggtggggtcactctggcagctcagagagggtgggagtgggtccaat 125 - 98677.doc 200533758 gcactttgttctggctcttccaggctgggagagcctttcaggggtgggacaccctgtgat ggggccctgcctcctttgtgaggaagccgctggggccagttggtcccccttccatggact ttgttagtttctccaagcaggacatggacaaggatgatctaggaagactttggaaagagt aggaagactttggaaagacttttccaaccctcatcaccaacgtctgtgccatttt >848_at HG-U95Av2 tccaggctcgtcattggaggtgaacaagcaaacccagacggctccactaggacttcaaat tgggggttggatttgaagacttttaagtttccttccagcccagaaagtetcteattctag cctcctggcccaggtgagtcctagagctacaggggttctggaaacattcaggagcttcct gtcctcccagctcctcactcaccttcagtaacccccactggactgacctggtccacaggg cacctgccaccctgggcctggcagctcagcttcccaacacgcaggagcacacccagcccc cacatcctgtgcctccatcagctaaacaccacgtcacttcatgcaggtgaaacccagtca ctgtgagctcccaggtgcagccagaggcacctcaaga >849_g_at HG-U95Av2 tttggtgctttccagaatcccgtaacacctgattaactgaggcatccacttctttcagca gactgatcaggacctccaagccactgagcaatgtataaccc≫ 626_s_at HG-U95Av2 cgggctctgctctgatcacctttgatgaccccaaagtggctgagcaggtgctgcaacaaa aggagcacacgatcaacatggaggagtgccggctgcgggtgcaggtccagcccttggagc tgcccatggtcaccaccatccaggtgtccagccagttgagtggccggagggtgttggtca ctggatttcctgccagcctcaggctgagtgaggaggagctgctggacaagctagagatct tctttggcaagactaggaacggaggtggcgatgtggacgttcgggagctactgccaggga gtgtcatgctggggtttgctagggatggagtggctcagcgtctgtgccaaatcggccagt tcacagtgccactgggtgggcagcaagtccctctgagagtctctccgtatgtgaatgggg agatccagaaggctgagatcaggtcgcagccagttccccgctcggtactggtgctcaaca ttcctgatatcttggatggcccggagctgcatgacgtcctggagatccacttccagaagc ccacccgcgggggcggggaggtagaggccctgacagtcgtaccccaag > 669_s_at HG-U95Av2 gagaccagtgtatcaggtcagggacttggacaggagtcagtgtctggctttttcctctga gcccagctgcctggagagggtctcgctgtcactggctggctcctaggggaacagaccagt gaccccagaaaagcataacaccaatcccagggctggctctgcactaagagaaaattgcac taaatgaatctcgttcccaaagaactacccccttttcagctgagccctggggactgttcc aaagccagtgaaatgtgaaggaaagtggggtccttcggggcgatgctccctcagcctcag aggagctctaccctgctccctgctttggctgaggggcttgggaaaaaaact tggcacttt ttcgtgtggatcttgccacatttctgatcagaggtgtacactaacatttcccccgagctc ttggcctttgcatttatttatacagtgccttgctcggcgcccaccaccccctcaagcccc agcagccctcaacaggcccagggagggaagtgtgagcgccttggtatgacttaaaattgg > 706_at HG-U95Av2 TIGRSequence > 712_s_at HG-U95Av2 TIGRSequence > 717 a at HG-U95Av2 gttcggatttgactgcctgtatatgttttgtgaaatggtcctgtttttgggtaggtgaca cgtggactctagtatgtaaatgttacttgaatctgtgcttcataatagtgtgtggcatgt atgtgcagactcttggatgctttatgcctgcgcaccaggagccctgtcctcacgttccca ggagggcggcttcacccttcgtaaccaggagacaaggcggccatggatttgcccttgatt ctattttgctaatggaagatagaaaggagagaaggtttttttttttttttaacattctga agatggtgctgtgtcaagaaggaccttttttttcccctctcccctattttttaagtacct tggaggaggagaggttggtgacatgcatggtggggatctatggcctctggtgctt > 823_at HG-U95Av2 acctgaggggcctcttatgggctgggttctacccaggtgctaggaacactccttcacaga tgggtgcttggaggaaggaaacccagctctggtccatagagagcaaaacgctgtgctgcc ctgcccaccctggcctctgcactcccctgctgggtgtggcgcagcatattcaggaagctc agggccctggctcaggtggggtcactctggcagctcagagagggtgggagtgggtccaat 125 - 98677.doc 200533758 g cactttgttctggctcttccaggctgggagagcctttcaggggtgggacaccctgtgat ggggccctgcctcctttgtgaggaagccgctggggccagttggtcccccttccatggact ttgttagtttctccaagcaggacatggacaaggatgatctaggaagactttggaaagagt aggaagactttggaaagacttttccaaccctcatcaccaacgtctgtgccatttt > 848_at HG-U95Av2 tccaggctcgtcattggaggtgaacaagcaaacccagacggctccactaggacttcaaat tgggggttggatttgaagacttttaagtttccttccagcccagaaagtetcteattctag cctcctggcccaggtgagtcctagagctacaggggttctggaaacattcaggagcttcct gtcctcccagctcctcactcaccttcagtaacccccactggactgacctggtccacaggg cacctgccaccctgggcctggcagctcagcttcccaacacgcaggagcacacccagcccc cacatcctgtgcctccatcagctaaacaccacgtcacttcatgcaggtgaaacccagtca ctgtgagctcccaggtgcagccagaggcacctcaaga > 849_g_at HG-U95Av2 tttggtgctttccagaatcccgtaacacctgattaactgaggcatccacttctttcagca gactgatcaggacctccaagccactgagcaatgtataaccc

>873_at HG-U95Av2 atagcgcctgtataagtagatctgctttctgttcatctctttgtcctgaatggctttgtc ttgaaaaaaaatagatgttttaacttatttatatgaagcaagctgtgttacttgaagtaa ctataacaaaaaaagaaagagaaaaaaaaaaacacacaaaaagtcccccttcaatctcgt ttagtgccaatgttgtgtgttgcactcaagttgtttaactgtgcatgtgcgtggaagtgt tcctgtctcaatagctccaagctgttaaagatatttttattcaaactacctatattcctt gtgtaattaatgctgttgtagaggtgacttgatgagacacaacttgttcgacgtgtagtg actagtgactctgtgatgaaaactgtgactccaagcggtgtgtccctgcgtgcctttata ggaccctttgcacgaactctggaagtggctcttataagcgcagcttcagtgatgtatgtt t >874_at HG-U95Av2 gagcagtttgccctgggttccctccttccacctgcgttcctcctctagctcccatggcag ccctttggtgcagaatgggctgcacttctagaccaaaactgcaaaggaacttcatctaac tctgtcctccctccccacagcttacagaccattgtgg >875_g_at HG-U95Av2 tgggttcaggattccatggaccacctggacaagcaaacccaaactccgaagacttgaaca ctcactccacaacccaagaatctgcagctaacttatttttccctagctttccccagacac cttgtttattttattataatgaattttgtttgttgatgtgaaacattatgccttaagtaa tgttaattcttatttaagttattgatgttttaagtttatctttcatggtactagtgtttt ttagatacagagacttggggaaattgcttttcctcttgaaccacagttctacccctggga tgttttgagggtctttgcaagaatc >925_at HG-U95Av2 gaggcctgcgtgttggatgaacttgacatggagctagccttcctgaccatgtctggcatg gcatggaagagtttgaggacatggagagaagtctgccactatgcctgcagctctacgccc cagggctgtcgccagaactatcatggagtgtgcaatgggggaccgcggcatgcagctcat gcacgccaacgcccagcggacagatgctctccagccaccgcacgagtatgtgccctgggt caccgtcaatgggaaacccttggaagatcagacccagctccttacccttgtctgccagtt gtaccagggcaagaagccggatgtctgcccttcctcaaccagctccctccggagtgtttg cttcgagtgttggccggtgggctgcggagagctcatggaaggcgagtgggaactcggctg cctgcctttttttctgatccagaccctcggcacctgctacttaccaactggaaaatttta tgcatcccatgaagcccagatacacaaaattccacccctagatcaagaatcctgctccac taagaat >943_at HG-U95Av2 gacggtataacacatctactgaaaaagcaacgggaaatgtggtcctatttaagccagccc ccacctagggtctatttgtgtggcagttattgggtttggtcacaaaacatcctgaaaatt cgtgcgtgggcttctttctccctggtacaaacgtatggaatgcttcttaaaggggaactg tcaagctggtgtcttcagccagatgacatgagagaatatcccagaaccctctctccaagg tgtttctagatagcacaggagagcaggcactgcactgtccacagtccacggtacacagtc gggtgggccgcctcccctctcctgggagcattcgtcgtgcccagcctgagcagggcagct 126- 98677.doc 200533758 ggactgctgctgttcaggagccaccagagccttcctctctttgtaccacagtttcttctg taaatccagtgttacaatcagtgtgaatggc >962_at HG-U95Av2 cttcccagctcttagaaatgtgctacgatgtctgtgaaggcatggccttcttggagagtc accaattcatacaccgggacttggctgctcgtaactgcttggtggacagagatctctgtg tgaaagtatctgactttggaatgacaaggtatgttcttgatgaccagtatgtcagttcag tcggaacaaagtttccagtcaagtggtcagctccagaggtgtttcattacttcaaataca gcagcaagtcagacgtatgggcatttgggatcctgatgtgggaggtgttcagcctgggga agcagccctatgacttgtatgacaactcccaggtggttctgaaggtctcccagggccaca ggctttaccggccccacctggcatcggacaccatctaccagatcatgtacagctgctggc acgagcttccagaaaagcgtcccacatttcagcaactcctgtcttccat≫ 873_at HG-U95Av2 atagcgcctgtataagtagatctgctttctgttcatctctttgtcctgaatggctttgtc ttgaaaaaaaatagatgttttaacttatttatatgaagcaagctgtgttacttgaagtaa ctataacaaaaaaagaaagagaaaaaaaaaaacacacaaaaagtcccccttcaatctcgt ttagtgccaatgttgtgtgttgcactcaagttgtttaactgtgcatgtgcgtggaagtgt tcctgtctcaatagctccaagctgttaaagatatttttattcaaactacctatattcctt gtgtaattaatgctgttgtagaggtgacttgatgagacacaacttgttcgacgtgtagtg actagtgactctgtgatgaaaactgtgactccaagcggtgtgtccctgcgtgcctttata ggaccctttgcacgaactctggaagtggctcttataagcgcagcttcagtgatgtatgtt t > 874_at HG-U95Av2 gagcagtttgccctgggttccctccttccacctgcgttcctcctctagctcccatggcag ccctttggtgcagaatgggctgcacttctagaccaaaactgcaaaggaacttcatctaac tctgtcctccctccccacagcttacagaccattgtgg > 875_g_at HG-U95Av2 tgggttcaggattccatggaccacctggacaagcaaacccaaactccgaagacttgaaca ctcactccacaacccaagaatctgcagctaacttatttttccctagctttccccagacac cttgtttattttattataatgaattttgtttgttgatgtgaaacattatgccttaagtaa tgttaattcttatttaagttattgatgttttaagtttatctttcatggtactagtgtttt ttagatacagagacttggggaaattgcttttcctcttgaac cacagttctacccctggga tgttttgagggtctttgcaagaatc > 925_at HG-U95Av2 gaggcctgcgtgttggatgaacttgacatggagctagccttcctgaccatgtctggcatg gcatggaagagtttgaggacatggagagaagtctgccactatgcctgcagctctacgccc cagggctgtcgccagaactatcatggagtgtgcaatgggggaccgcggcatgcagctcat gcacgccaacgcccagcggacagatgctctccagccaccgcacgagtatgtgccctgggt caccgtcaatgggaaacccttggaagatcagacccagctccttacccttgtctgccagtt gtaccagggcaagaagccggatgtctgcccttcctcaaccagctccctccggagtgtttg cttcgagtgttggccggtgggctgcggagagctcatggaaggcgagtgggaactcggctg cctgcctttttttctgatccagaccctcggcacctgctacttaccaactggaaaatttta tgcatcccatgaagcccagatacacaaaattccacccctagatcaagaatcctgctccac taagaat > 943_at HG-U95Av2 gacggtataacacatctactgaaaaagcaacgggaaatgtggtcctatttaagccagccc ccacctagggtctatttgtgtggcagttattgggtttggtcacaaaacatcctgaaaatt cgtgcgtgggcttctttctccctggtacaaacgtatggaatgcttcttaaaggggaactg tcaagctggtgtcttcagccagatgacatgagagaatatcccagaaccctctctccaagg tgtttctagatagcacaggagagcaggcactgcactgtccacagtccacggtacacagtc gggtgggccgcctcccctctcctgggagcattcgtcgtgcccagcctgag cagggcagct 126- 98677.doc 200533758 ggactgctgctgttcaggagccaccagagccttcctctctttgtaccacagtttcttctg taaatccagtgttacaatcagtgtgaatggc > 962_at HG-U95Av2 cttcccagctcttagaaatgtgctacgatgtctgtgaaggcatggccttcttggagagtc accaattcatacaccgggacttggctgctcgtaactgcttggtggacagagatctctgtg tgaaagtatctgactttggaatgacaaggtatgttcttgatgaccagtatgtcagttcag tcggaacaaagtttccagtcaagtggtcagctccagaggtgtttcattacttcaaataca gcagcaagtcagacgtatgggcatttgggatcctgatgtgggaggtgttcagcctgggga agcagccctatgacttgtatgacaactcccaggtggttctgaaggtctcccagggccaca ggctttaccggccccacctggcatcggacaccatctaccagatcatgtacagctgctggc acgagcttccagaaaagcgtcccacatttcagcaactcctgtcttccat

-127- 98677.doc 200533758 表2b ··確認表lb之轉錄本的探針序列 >152 9__at HG-U9 5AV2 aattactgtatctaaaaggagctgctatgaagtacctttcttatgttgctaggctactgt ttctgaaagccctggatctctttgcaccaaaaatggtccagatagactctttttaaggat cttggctgctttttactagaaggttgcttttatgagcatatttatactgctgaaggatga gtgttaattttaattaactttgccgttttgtagagaaaactattcacaagataaattcca agtcttttcacctgtcaggcatgca >31849_at HG-U95Av2 aaattcacagtactccattttggggtccaaactgtaatgctcaaaataataaatgcttac acgaaaattatttattgagaatattcatataaaaattacctaaagcaaagtaaaaaaagt aaaatcaaggtggtatatttgaagtgaatggtgattggaaatttttagctgtaacaaaaa gaaagaaaacaactttttttaaagcctcattctcttttctttcaaaatgtaccttattcc cacacactcttgggctgacctttattttatcaataagctcaatattactttgtttaaaat aagannnnnnnnnnnnnnncattctctctttaaccatataatttaaaaactcctcttcac gattgatagcaaaatcagaaacgttaggnnnnnnnnnnnnnnnnnnnnnnnnnnntaagt-127- 98677.doc 200533758 Table 2b ·· probe-transcript sequences of Table lb > 152 9__at HG-U9 5AV2 aattactgtatctaaaaggagctgctatgaagtacctttcttatgttgctaggctactgt ttctgaaagccctggatctctttgcaccaaaaatggtccagatagactctttttaaggat cttggctgctttttactagaaggttgcttttatgagcatatttatactgctgaaggatga gtgttaattttaattaactttgccgttttgtagagaaaactattcacaagataaattcca agtcttttcacctgtcaggcatgca > 31849_at HG-U95Av2 aaattcacagtactccattttggggtccaaactgtaatgctcaaaataataaatgcttac acgaaaattatttattgagaatattcatataaaaattacctaaagcaaagtaaaaaaagt aaaatcaaggtggtatatttgaagtgaatggtgattggaaatttttagctgtaacaaaaa gaaagaaaacaactttttttaaagcctcattctcttttctttcaaaatgtaccttattcc cacacactcttgggctgacctttattttatcaataagctcaatattactttgtttaaaat aagannnnnnnnnnnnnnncattctctctttaaccatataatttaaaaactcctcttcac gattgatagcaaaatcagaaacgttaggnnnnnnnnnnnnnnnnnnnnnnnnnnntaagt

tggaaaaactattattaataatattatcctatccatccatatctattgaaattgtacagg tccataatttcattttaattaattataggaaagaagaaaagataatacccatttgttcta tcacccctctccctatcattaactatcaaataaataaataaaagcaatctgatttccaac gtggta >32110_at HG-U95AV2 atgatctgccagagcctctccaggggtggaatacatgnccnggactaagnccaatgacan ccttnccatctttnccagctatggtgactgggttaggtatgatncttgtgagttaagaca atgaagnccagagggaatttcaagacttatgggaatgctgggtagaagctgttttaattc ccctgttgaatgtgaaaaaggtagtagtattcctgggtctttatgatgaccaccttgggc cttgggatcatgaccaggaatcacgtgaagctgacaccactgaagggagagttgagaggc agaaagagatcaagtccttggtgaaattgtttaagtacaggatcaagccttgcttgagat tggccttacct >32385_at HG-U95Av2 gtcatcttgtaattctatgtgtaactttggaggaatttccaaactgttttctgcaatggc tgcaccattttacattcctgtcagcaatgtacaggattccagtttctccatatccctgcc aacacttggtattttcctttttttcagttagttactctagtgggtatgtggtggttgtcc cattgctgtttgttttgattttcattgtccctaatgactaatgatattgagcatctaata tccagttgtcccagcaacatttgtttgaagagactattctttcctgtgtaaatggtcttg gcatctttgttgaaaatcgattggcagccaggtgcagtagctcacacctgtaatcccagc actttgggaggctgcgctgggcagatcgcttaagct >32791_at HG-U95Av2 ttgtaaacagatcatcctaggcgaaagttttttttgtttgtttgcttttaaattagttta tttctaaatcttagtcttccacatttctagaggccacctgacacaagtccctgtatctga ag t c t annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnag t ggataact taatcttttaatacagttccgtcattcccatcttgttttcagaagagaaggtnnnnnnnn nnnnnnnnaacatatccactgtgtgcatagagggtctcttcacgttgatgcttggcattc catcagctttctctaagtctttgctcaagttcaaccttaaaatgatgttagacaacaggt cccagtcagttccctctattttcacccattttgctcacaagccatattggcccgattagt ggtactgtctgactcacgtgtgtgatccaaataaaggtagctgctgaccannaaanaaaa aaaaaaaaaaaaaannnnanananaanccagggttctctcatgaggagttaa >33325_at HG-U95Av2 catcccaaagtcaaacatgggcaagaggtgannnnnnnnnnnnnnnnnnnnnnnnnnntt tgtctgtgattttaaactaactgtgtatgtattgatgtttggaagattgtttgaatttta aagtgataatagtacttaatgttatccagtattgtteattaaatggtgttatcctaaagc tgcacttgggatttttacctaacgctttactgattctctcaagcacatggncaaagtttg antttgcactccgttcatttctgacacgttttgctgnccteetacctttctaagcgteat gcaaattcgagaatggagaaggacgctgccggtccctgagcggtgtggagagggcggaag gtggactccagcgcagcttgaggggctgaggacggaggctgcagcatctgtgtcgttcta ctgagcacgcttetctgeetcgctcctgacnnnnnnnnnnnnnnnnnnnntcageagtta -128- 98677.doc 200533758 tgtttacacatcatttttatgttcctgctttgtaattcatgtttgagatgggtggccact gtaca >33924一at HG-U95AV2 gtcgcattaatgaggcccttccacatcatttttaaactaatgtttttctatattaacatt attatggatatttggctttc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn c c c a t g c tccaatcaaagggatttttagtagtgcctctaagcaagcaccgatgagtcagtcccacgt attttcttttttgtcagtattgtttgggaaggagacatgccgggatgtgtcatcgtgcca aataccacatttcctgttggcacagtttcacagaagtaaacataagcatgttttaacagg tttttcttttcttttttcttttttaaaatgttttatttatttaacccgccattgtgtgtt tttaagtattttcttttnnnnnnnnnnnnnnnnnnnnnnnncaatctaactggctatgtt attattattaaatttatgttttgcaacttagaaaccagctacagtatgg >34176_at HG-U95Av2 ggagcttattcctggctccatcgctaacacgttgactgcttattatgggaaanttttctc tgaagccagggagaagcattgattgatgtgggcaaatccaagctccagccaggtcgcagt cccaaatgccgacatcactgactccagggaccagggacatggagaaagctgtttatgata tctttaaccaggccctcttnactagagctggtgtttgtgactggnccaacaagatgtggc tatgnccaggggacatctgagtatgtgncccagtcatcttttttcacaggttgaagggagtggaaaaactattattaataatattatcctatccatccatatctattgaaattgtacagg tccataatttcattttaattaattataggaaagaagaaaagataatacccatttgttcta tcacccctctccctatcattaactatcaaataaataaataaaagcaatctgatttccaac gtggta > 32110_at HG-U95AV2 atgatctgccagagcctctccaggggtggaatacatgnccnggactaagnccaatgacan ccttnccatctttnccagctatggtgactgggttaggtatgatncttgtgagttaagaca atgaagnccagagggaatttcaagacttatgggaatgctgggtagaagctgttttaattc ccctgttgaatgtgaaaaaggtagtagtattcctgggtctttatgatgaccaccttgggc cttgggatcatgaccaggaatcacgtgaagctgacaccactgaagggagagttgagaggc agaaagagatcaagtccttggtgaaattgtttaagtacaggatcaagccttgcttgagat tggccttacct > 32385_at HG-U95Av2 gtcatcttgtaattctatgtgtaactttggaggaatttccaaactgttttctgcaatggc tgcaccattttacattcctgtcagcaatgtacaggattccagtttctccatatccctgcc aacacttggtattttcctttttttcagttagttactctagtgggtatgtggtggttgtcc cattgctgtttgttttgattttcattgtccctaatgactaatgatattgagcatctaata tccagttgtcccagcaacatttgtttgaagagactattctttcctgtgtaaatggtcttg gcatctttgttgaaaatcgattggcagccaggtgcagtagctcacacctgtaatcccagc actttgggaggctgcgctgg gcagatcgcttaagct > 32791_at HG-U95Av2 ttgtaaacagatcatcctaggcgaaagttttttttgtttgtttgcttttaaattagttta tttctaaatcttagtcttccacatttctagaggccacctgacacaagtccctgtatctga ag t c t annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnag t ggataact taatcttttaatacagttccgtcattcccatcttgttttcagaagagaaggtnnnnnnnn nnnnnnnnaacatatccactgtgtgcatagagggtctcttcacgttgatgcttggcattc catcagctttctctaagtctttgctcaagttcaaccttaaaatgatgttagacaacaggt cccagtcagttccctctattttcacccattttgctcacaagccatattggcccgattagt ggtactgtctgactcacgtgtgtgatccaaataaaggtagctgctgaccannaaanaaaa aaaaaaaaaaaaaannnnanananaanccagggttctctcatgaggagttaa > 33325_at HG-U95Av2 catcccaaagtcaaacatgggcaagaggtgannnnnnnnnnnnnnnnnnnnnnnnnnntt tgtctgtgattttaaactaactgtgtatgtattgatgtttggaagattgtttgaatttta aagtgataatagtacttaatgttatccagtattgtteattaaatggtgttatcctaaagc tgcacttgggatttttacctaacgctttactgattctctcaagcacatggncaaagtttg antttgcactccgttcatttctgacacgttttgctgnccteetacctttctaagcgteat gcaaattcgagaatggagaaggacgctgccggtccctgagcggtgtggagagggcggaag gtggactccagcgcagcttgaggg gctgaggacggaggctgcagcatctgtgtcgttcta ctgagcacgcttetctgeetcgctcctgacnnnnnnnnnnnnnnnnnnnntcageagtta -128- 98677.doc 200533758 tgtttacacatcatttttatgttcctgctttgtaattcatgtttgagatgggtggccact gtaca > 33924 a at HG-U95AV2 gtcgcattaatgaggcccttccacatcatttttaaactaatgtttttctatattaacatt attatggatatttggctttc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn c c c a t g c tccaatcaaagggatttttagtagtgcctctaagcaagcaccgatgagtcagtcccacgt attttcttttttgtcagtattgtttgggaaggagacatgccgggatgtgtcatcgtgcca aataccacatttcctgttggcacagtttcacagaagtaaacataagcatgttttaacagg tttttcttttcttttttcttttttaaaatgttttatttatttaacccgccattgtgtgtt tttaagtattttcttttnnnnnnnnnnnnnnnnnnnnnnnncaatctaactggctatgtt attattattaaatttatgttttgcaacttagaaaccagctacagtatgg > 34176_at HG-U95Av2 ggagcttattcctggctccatcgctaacacgttgactgcttattatgggaaanttttctc tgaagccagggagaagcattgattgatgtgggcaaatccaagctccagccaggtcgcagt cccaaatgccgacatcactgactccagggaccagggacatggagaaagctgtttatgata tctttaaccaggccctcttnactagagctggtgtttgtgactggnccaacaagatgtggc tatgnccaggggacatctgagtatgtgnccca gtcatcttttttcacaggttgaagggag

agaaaagattttgagttaaggtcattggctgctctactctgtcccctacctggtcaccta gtgatagccccagtggagatactgtccatacaaggtnnnnnnnnnnnnnnnataccacag taaaaggccaggccaggaggggtaggagactatggagatcttacctcctgataaatg >34303_at HG-U95Av2 aatgtcaaccggagcccttacaccagccctccagcatctaatnnacttnnaanntnnnnt naannnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nntggcagcggncttatccttctctgttgccaaccttgccgtccgacctcctccgccccc atgcggtgaccccgtccgtgtctgtgtctgtccatacgtgtgagtccagctaaaaagaca aaacagaaccnnnnnnnnnnnnnnnnnnnnnnnntggagaaggctccgacgtctccgaag tgcagcccttgggatggcattccgttgtgtgccttattcctggagaatctgtatacggct cgcctatagaaatatagcct >34678一at HG-U95Av2 ccgaactatttgtcaatgaagattgtaaagccaaatgtgtaacaaaggcaaaggcttcat ttcaagagtcatccagcaatgagagaatcctgcctctgtagaccaacatccagtgtgatt ttgtgtctgagaccacaccccagtagcaggttacgccntgnnnncnnnnnncnnnnntnn nnnnnngnnnntnnnnnncnnnnnnnnnnnnnnnaacnnnnnnnnnnnnnnnnntgttat ctcttaagtattaaaagttttattttctaaagtttaaatcatgtttttcaaaatattttt caaggtggctggttccatttaaaaatcatctttttatatgtgtcttcggttctagacttc agcttttggaaattgctaaatagaattcaaaaatctctgcatcctgaggtgatatacttc atatttgtaat nnnnnnnnnnnnnnnnnnnnnnna annnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngcccacaaccattgctatattttgtatgga >34800_at HG-U95AV2 tggccaaaagctgaagggagttactgagaaaatagttaacaattactgtcaggtgtcatc actgttcaaaaggtaagcacatttagaattttgttcttgacagttaactgactaatctta cttccacaaaatatgtgaatttgctgcttctgagaggcaatgtgaaagagggagtattac ttttatgtacaaagttatttatttatagaaattttggtacagtgtacattgaaaaccatg taaaatattgaagtgtctaacaaatggcattgaagtgtctttaataaaggttcatttata aatgtcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaannnngncnnnaattatc tttcccccaaaaaagaaaaaaaaaataggcgaagcaaaatcacatactgtttgttnnnnn nnnnnnnnnnnnnnntgctagattcctgacattttgttttgaatttttctacacctggag cttgt >34857一at HG-U95Av2 gaaagctttcccaattgcacttgcatctaaacaaaactgttgcagtttttactctattta ttttgttccccatgtttatgaaagtcctgcacagtttcaaaggcatggtaaataatatat caatgtttatgtagtctgttacagaaacagctatagataacattatccagtgaagagcaa aattcaagctttagaaaatattcatgcatgcaattttgacatatctaaaaataggttttt gtatatttatggtgggaggtggttgggaacttttaacaaaatggggtgttaatttttgta 129- 98677.doc 200533758 cagtctgtgggcatttacacatttttaatgtattaaaatttggtaattatgtgtacatta aattaataaaagttacttctagttatgatttgtgaattccctaagaccttggattttttt aagtaactttatatcagaaatgatactgcatctttatatttttaaaattgtattgctgct caagaatggtaccctcttgtcaaaaaggcat >35484一at HG-U95Av2 acactgttttgtaatgatcgctttgcatgtcttttccagctgactccgccaccatctcct gcctggatgactgcagcagcatccttgctggcctctctgcttcctgcattgcctcctctg aatcttcaggatgccaagtttgtggaggaacggagannnnnnnnnnnnnnnnnnnnnnnn anngtcatgaacaaagtcatccagatggtccccgagttcgctgccagccccnannangnn nnccnnnnncnnnnnnnngcccttcttcgtgatgggattacaggtcggaatgtacggatt gtttcattttggggtaatgatggatcagccacagccaagccttacccgtgctgacgaatc t >357 63__at HG-U95Av2 ttgcccatgaaggtggccatccgcagcgtggccgtgaccaaggagcgcagccacgtgctg gtgggcctggaggatggcaagctcatcgtggtggtcgcggggcagccctctgaggtgcgc agcagccagttcgcgcggaagctgtggcggtcctcgcggcgcatctcccaggtgtcctcgagaaaagattttgagttaaggtcattggctgctctactctgtcccctacctggtcaccta gtgatagccccagtggagatactgtccatacaaggtnnnnnnnnnnnnnnnataccacag taaaaggccaggccaggaggggtaggagactatggagatcttacctcctgataaatg > 34303_at HG-U95Av2 aatgtcaaccggagcccttacaccagccctccagcatctaatnnacttnnaanntnnnnt naannnannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nntggcagcggncttatccttctctgttgccaaccttgccgtccgacctcctccgccccc atgcggtgaccccgtccgtgtctgtgtctgtccatacgtgtgagtccagctaaaaagaca aaacagaaccnnnnnnnnnnnnnnnnnnnnnnnntggagaaggctccgacgtctccgaag tgcagcccttgggatggcattccgttgtgtgccttattcctggagaatctgtatacggct cgcctatagaaatatagcct > 34678 a at HG-U95Av2 ccgaactatttgtcaatgaagattgtaaagccaaatgtgtaacaaaggcaaaggcttcat ttcaagagtcatccagcaatgagagaatcctgcctctgtagaccaacatccagtgtgatt ttgtgtctgagaccacaccccagtagcaggttacgccntgnnnncnnnnnncnnnnntnn nnnnnngnnnntnnnnnncnnnnnnnnnnnnnnnaacnnnnnnnnnnnnnnnnntgttat ctcttaagtattaaaagttttattttctaaagtttaaatcatgtttttcaaaatattttt caaggtggctggttccatt taaaaatcatctttttatatgtgtcttcggttctagacttc agcttttggaaattgctaaatagaattcaaaaatctctgcatcctgaggtgatatacttc atatttgtaat nnnnnnnnnnnnnnnnnnnnnnna annnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnngcccacaaccattgctatattttgtatgga > 34800_at HG-U95AV2 tggccaaaagctgaagggagttactgagaaaatagttaacaattactgtcaggtgtcatc actgttcaaaaggtaagcacatttagaattttgttcttgacagttaactgactaatctta cttccacaaaatatgtgaatttgctgcttctgagaggcaatgtgaaagagggagtattac ttttatgtacaaagttatttatttatagaaattttggtacagtgtacattgaaaaccatg taaaatattgaagtgtctaacaaatggcattgaagtgtctttaataaaggttcatttata aatgtcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaannnngncnnnaattatc tttcccccaaaaaagaaaaaaaaaataggcgaagcaaaatcacatactgtttgttnnnnn nnnnnnnnnnnnnnntgctagattcctgacattttgttttgaatttttctacacctggag cttgt > 34857 a at HG-U95Av2 gaaagctttcccaattgcacttgcatctaaacaaaactgttgcagtttttactctattta ttttgttccccatgtttatgaaagtcctgcacagtttcaaaggcatggtaaataatatat caatgtttatgtagtctgttacagaaacagctatagataacattatccagtgaagagcaa aattcaagctttagaaaatattcatgcatgcaattttgacatatctaaaaataggttttt gtatat ttatggtgggaggtggttgggaacttttaacaaaatggggtgttaatttttgta 129- 98677.doc 200533758 cagtctgtgggcatttacacatttttaatgtattaaaatttggtaattatgtgtacatta aattaataaaagttacttctagttatgatttgtgaattccctaagaccttggattttttt aagtaactttatatcagaaatgatactgcatctttatatttttaaaattgtattgctgct caagaatggtaccctcttgtcaaaaaggcat > 35484 a at HG-U95Av2 acactgttttgtaatgatcgctttgcatgtcttttccagctgactccgccaccatctcct gcctggatgactgcagcagcatccttgctggcctctctgcttcctgcattgcctcctctg aatcttcaggatgccaagtttgtggaggaacggagannnnnnnnnnnnnnnnnnnnnnnn anngtcatgaacaaagtcatccagatggtccccgagttcgctgccagccccnannangnn nnccnnnnncnnnnnnnngcccttcttcgtgatgggattacaggtcggaatgtacggatt gtttcattttggggtaatgatggatcagccacagccaagccttacccgtgctgacgaatc t > 357 63__at HG-U95Av2 ttgcccatgaaggtggccatccgcagcgtggccgtgaccaaggagcgcagccacgtgctg gtgggcctggaggatggcaagctcatcgtggtggtcgcggggcagccctctgaggtgcgc agcagccagttcgcgcggaagctgtggcggtcctcgcggcgcatctcccaggtgtcctcg

ggagagacggaatacaaccctactgaggcgcgcnnnnnnnnnnnnnnncggctgctcggg ccccgcccccggcaggcctggcccgggaggccccgcccagaagtcggcgggaacaccccg gggtgggcagcccangggggtgagcggggcccaccnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnccctcagggattggcgggcggaagtcccgcccctcgccggctgaggggccg ccctgagggccagcactggcgtctgcggccgctgnnnnnnnnnnnnnnnagtctggggnn gggttccccggcttccaagtcgctg >358 61__at HG-U95Av2 gatgctgcccttctttgcacgaaagcctggccctcttgctttggcgtgataaacccctgt ccatcttccccaaagctcatttatgagcccacccagaggctcctacccccaaagattttc acagaaacttgaggcc >35959__at HG-U95Av2 gatettcagaaagtaccataatgtcatcctactctacatttcacaagacgaattattttg agatttgtttattatattaaaatgtttttttacgttcccactaaattttgaccccatata aagaaatgtgttatgtatgttgtgcctccttagagacataaatttagtgtcaaaacatgg gagatggcttactcagaagcatactccacttaacataccatggcctgagctaagtaccat gtcctgtttgtgtcttatttttaaatattttctttgtccacatgggccgttgaccttaga gttaaggcggttngcttttttgaagaaatcanccaaagtttctgggaaactatgttncaa ggttgaaatggagagtagatttaattttatttgtcttgtagggaagaaatcttcctttga accgcttttcttgctttttccctttttcccaaactaggttacaggttcttatctgcaagg ttcaagttgcttagacattgttttccagtattctgcagggccagtcagttgtacagaagt t >36014_at HG-U95Av2 gttctaagcatgcagttctcacctccatttagtcccccatcagaacagnnnnnnnnnnnn nnnnnnnggagcctaaatttagttcagcttacctttgagaatagcatcaattcagactct cttttcattatgttttcttttctttttccctctttttaaactacattgtgttagagtcat agtctaggatcctgagagattttccattcttgtcaccattcacttgcattgtaaagattt tctttgtctgttgttggcatagattcttttgtacatatttatttatttgtgtttatatat gtcaattggtttcctttcttagcttgatattgcctagctttgttgttttaattaactttc tattagagagactgtatatattttttctaaatactttgtgaaatcatttttggtagcaat atctttgaatatgatgaataaaagtgactgtgagtgcaaatagaattagcagtaagaagc tactctagctaatttgccat >36250_at HG-U95Av2 gccccagacccttgaaggaaggtgctccccttcacacacccaggctggaaannnnnnnnn nnnnnngacggcttgatggtagccaggaccteetetttactgcgggggtgggcgggggcg gaggatgggaactggctagtgagccctgaaata >36336_s_at HG-U95Av2 cccggagaggtgctggacctcacctacagccccccggccgaggccttcccgccgcccccg cacttctctttcccggcgccgctgtccctggacgccggccccggcgtcgtgccgctgggc 130- 98677.doc 200533758 acccccgacgcccaggccgaccctgcggccctcgcgcaccagggctgcgacatcaacttc aaggaggtgctggaggacatgctgcgctcgctgcacgcggggccgccctccgagggcgcg ctgggggagggcgcgggggcggggggcgcggcgggcggtggtcccgagcggcagagcgtg atccagttcagcccacc >36497_at HG-U95Av2 attcacacggtactcagaggcactgntggggaagtttgttggtctttattagataaattt ccagagacctgtccataatacccaacagaacatgactgtttctttgaggaaagggttata atgtctgtggtgtacaagtcgtttttggtataacttctttcctgctgctgctgcttcccg gcaaacatagttttcctatttcaggcagagtgcggtatattccaggaaacactgtttcct actcacttagcttacttctttgttgaatgcctcactaatggcaagtttcaagatgttttg ggtgacaatgcacacatgctgggcaaaagggtgatggccagtggctggcagctgggccag cagaagctaggacatctgtgagttgtcattctcatctatccatgtccactggcctgccag catccgccagtgccttgccagtgtgcacggtcccacactgtggcccctgagtcccctaat gtacacgctgcagccagaatgcagatggagctggcttggctgttccctggatg >37030—at HG-U95AV2 ccacgactgaagttgtagattgagcngaataaccatgggaagtgaccaagncaaagacac tcgattggnagtcagttgaatatttgtacccntcagtggagcccttctggntcttttctnggagagacggaatacaaccctactgaggcgcgcnnnnnnnnnnnnnnncggctgctcggg ccccgcccccggcaggcctggcccgggaggccccgcccagaagtcggcgggaacaccccg gggtgggcagcccangggggtgagcggggcccaccnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnccctcagggattggcgggcggaagtcccgcccctcgccggctgaggggccg ccctgagggccagcactggcgtctgcggccgctgnnnnnnnnnnnnnnnagtctggggnn gggttccccggcttccaagtcgctg > 358 61__at HG-U95Av2 gatgctgcccttctttgcacgaaagcctggccctcttgctttggcgtgataaacccctgt ccatcttccccaaagctcatttatgagcccacccagaggctcctacccccaaagattttc acagaaacttgaggcc > 35959__at HG-U95Av2 gatettcagaaagtaccataatgtcatcctactctacatttcacaagacgaattattttg agatttgtttattatattaaaatgtttttttacgttcccactaaattttgaccccatata aagaaatgtgttatgtatgttgtgcctccttagagacataaatttagtgtcaaaacatgg gagatggcttactcagaagcatactccacttaacataccatggcctgagctaagtaccat gtcctgtttgtgtcttatttttaaatattttctttgtccacatgggccgttgaccttaga gttaaggcggttngcttttttgaagaaatcanccaaagtttctgggaaactatgttncaa ggttgaaatggagagtagatttaattttatttgtcttgtagggaagaaatcttcctttga accgcttttcttgctttttccctttttcccaaactaggttacaggttcttatct gcaagg ttcaagttgcttagacattgttttccagtattctgcagggccagtcagttgtacagaagt t > 36014_at HG-U95Av2 gttctaagcatgcagttctcacctccatttagtcccccatcagaacagnnnnnnnnnnnn nnnnnnnggagcctaaatttagttcagcttacctttgagaatagcatcaattcagactct cttttcattatgttttcttttctttttccctctttttaaactacattgtgttagagtcat agtctaggatcctgagagattttccattcttgtcaccattcacttgcattgtaaagattt tctttgtctgttgttggcatagattcttttgtacatatttatttatttgtgtttatatat gtcaattggtttcctttcttagcttgatattgcctagctttgttgttttaattaactttc tattagagagactgtatatattttttctaaatactttgtgaaatcatttttggtagcaat atctttgaatatgatgaataaaagtgactgtgagtgcaaatagaattagcagtaagaagc tactctagctaatttgccat > 36250_at HG-U95Av2 gccccagacccttgaaggaaggtgctccccttcacacacccaggctggaaannnnnnnnn nnnnnngacggcttgatggtagccaggaccteetetttactgcgggggtgggcgggggcg gaggatgggaactggctagtgagccctgaaata > 36336_s_at HG-U95Av2 cccggagaggtgctggacctcacctacagccccccggccgaggccttcccgccgcccccg cacttctctttcccggcgccgctgtccctggacgccggccccggcgtcgtgccgctgggc 130- 98677.doc 200533758 acccccgacgcccaggccgaccctgcggccctcgcgcaccagggctg cgacatcaacttc aaggaggtgctggaggacatgctgcgctcgctgcacgcggggccgccctccgagggcgcg ctgggggagggcgcgggggcggggggcgcggcgggcggtggtcccgagcggcagagcgtg atccagttcagcccacc > 36497_at HG-U95Av2 attcacacggtactcagaggcactgntggggaagtttgttggtctttattagataaattt ccagagacctgtccataatacccaacagaacatgactgtttctttgaggaaagggttata atgtctgtggtgtacaagtcgtttttggtataacttctttcctgctgctgctgcttcccg gcaaacatagttttcctatttcaggcagagtgcggtatattccaggaaacactgtttcct actcacttagcttacttctttgttgaatgcctcactaatggcaagtttcaagatgttttg ggtgacaatgcacacatgctgggcaaaagggtgatggccagtggctggcagctgggccag cagaagctaggacatctgtgagttgtcattctcatctatccatgtccactggcctgccag catccgccagtgccttgccagtgtgcacggtcccacactgtggcccctgagtcccctaat gtacacgctgcagccagaatgcagatggagctggcttggctgttccctggatg > 37030-at HG-U95AV2 ccacgactgaagttgtagattgagcngaataaccatgggaagtgaccaagncaaagacac tcgattggnagtcagttgaatatttgtacccntcagtggagcccttctggntcttttctn

nnnnnnnnnnnnnntttcctctagncaaatacttctttctccttgcttgcctccaccatg atatttgaataagagatggccagaggataacacttgtctcttaaaaactaagctaaaaag aacctagaaccttcaattgagcagttgtgaaaattgctaatggtnccaaggccaagcaaa gagtttcagaaaatgactgagaaggagcgataacccccagaatgcaaaatcaggggcatc attatccggtgcttgaacaangnngntccgctctacaactggtttttttaggacttgtga ggaacacagcaacggaaatccatccacaaaggatgcagtgccccaacttgt >37216_at HG-U95Av2 accactgctcagaggagccctaggccctggccgcagtgccttcagcgcccgacccgggcc cccacctggtcagc cnnnnnnnnnnnnnnnnnnnnnnnnnnnng gc c ggggcgtggcagg gccctctctgtgcctctcctcccaagtaggaaggggctccgggtggctgctctgggactg ggcacccacaagggctcagtgggcccaaacccttnnnnnnnnnnnnnnnnnnnnnnncca agagctagaaactcaggaaaccccaggtgctcagggccccgcgtctcgggggctccgtgg ggcagacccctgctaatatatgcaattctccctcccccagcccttccctgacccctaagt tattgcccgctca >37786_at HG—U95Av2 cgtccattactcaaggagacagcataacagatgcagaacaagtcatatttgaagaatgtt ttgtactaaacttcatttaattattcagtttttaaagggaaaaagggcgtganctcacac agtgagctgtttatttaaatatcattaaggagaaaaaaaaatatggtgagaagctcgctc ctttcaacttgtttggtactgacagctgatagaagctattttctaataataaacatccag tgtgtgaaagacaaaaaaaaannantgcaatactctttttttaatgataaaacctgtgaa gtttcccaaagcaggttttaaaaggaaaaaaaggaaaagcaaaaaggttgctgttctcac tcccatctcatttagtgcatgtcttaattcgggattagtaatgaattggaggatcattag acatttctaggaacc >37788_at HG-U95AV2 catgaatcacatagagcagtggagttttanccaagtggtgtgtgtggtttttgtttttta ctatgcaaagatgggaaatgcacaaacttttcaaagactagtgtctgaagaactttacaa acaatacttgaaccctttctttaaagttatcccatcatgttttatagtcattgttgcttc cattgttagtttccattttcaagtgctttgtaattttttaagtgcactacctgaaatttt gtttgaaattaataaattcattcgtatcttgttggctgcctatgaatggagattcagtag tcattgtatgcatctttaagtcaaatgtgtattaaaactttcgttaacgtanaaaaaaaa aaannnannnnnnaannnnnnnnnnnnnncnnccttttctgtttcctcttgtagtgctga tta >38393_at HG-U95Av2 cccaaggtgggacttggagaatattttgcnttggcatatgtttggtctgaatggtgtagt tgctggttccctagagaggaaaaggtggcnnggcccnnnnnnnnnnnnnnnnnnnnctta atttccagttgaaaccctagtagaattgtgaatgaaaacctcaaggttgagncccctctg ccaagcagcagagctagtagaaggggatgcaggggcaaagcactcagttgccaagcaagg aggagagatgtacgtgggctgtgtggcagtccccacaccctgccctggcttcttcaggtt 131 - 98677.doc 200533758 atcgcaccactatggaatcctttgcagaatggtactcatataatggtttaaaacaacaca ttcataattgactctgtgcaggatgtcactcaatcagtttgggtttgcttt >38510_at HG-U95AV2 gtcctcccatattggcaaagataaagcaattgacaaaaatggaattcttgttcaatactg gcaggagtgaaaattggtagaacctttntagaaggcnattnggcnannatgtatgnaaan cntaaatgtngatacncctttacccagcagtttgtttnggaatttatcctaatgaataaa agttgnccnagncntcnaaacangannnnnaannnanatttcnatgatgtttatgatatt aaaacattggnaacaactgaaacatccntcagtaaaagatggattaaataaattccatgc nagttgtcatttaaaaatatttagatatatgtttattgctatggatatatgttcccaaaa tattattgaatcaaaaagtagactacaggatatatgttgaatatgagctcatttataaca ttgaatattttaagataatgtatgtttcatagagagatcttcaccaaatgttaaggattt >38717_at HG-U95AV2 tacaaggttgccacacctagttctgcccagctttatgtcttttattccagtattccacca aagtttgttttcctgncattccagttctcaagtcttaagnataaagattgtacttgacag tttagtatatccataaaactatttgaggtggttaaggttcttgggttcattttccttaat actttgctgaatattgtagattgtaggcdatgdaaaagtctactaaattdggeiaaacctl: gaataattaggtatcctaggtaagagcccctaaacatcaagcaatctgtgagtctgtaaannnnnnnnnnnnnntttcctctagncaaatacttctttctccttgcttgcctccaccatg atatttgaataagagatggccagaggataacacttgtctcttaaaaactaagctaaaaag aacctagaaccttcaattgagcagttgtgaaaattgctaatggtnccaaggccaagcaaa gagtttcagaaaatgactgagaaggagcgataacccccagaatgcaaaatcaggggcatc attatccggtgcttgaacaangnngntccgctctacaactggtttttttaggacttgtga ggaacacagcaacggaaatccatccacaaaggatgcagtgccccaacttgt > 37216_at HG-U95Av2 accactgctcagaggagccctaggccctggccgcagtgccttcagcgcccgacccgggcc cccacctggtcagc cnnnnnnnnnnnnnnnnnnnnnnnnnnnng gc c ggggcgtggcagg gccctctctgtgcctctcctcccaagtaggaaggggctccgggtggctgctctgggactg ggcacccacaagggctcagtgggcccaaacccttnnnnnnnnnnnnnnnnnnnnnnncca agagctagaaactcaggaaaccccaggtgctcagggccccgcgtctcgggggctccgtgg ggcagacccctgctaatatatgcaattctccctcccccagcccttccctgacccctaagt tattgcccgctca > 37786_at HG-U95Av2 cgtccattactcaaggagacagcataacagatgcagaacaagtcatatttgaagaatgtt ttgtactaaacttcatttaattattcagtttttaaagggaaaaagggcgtganctcacac agtgagctgtttatttaaatatcattaaggagaaaaaaaaatatggtgagaagctcgctc ctttcaacttgtttggtactgacagctg atagaagctattttctaataataaacatccag tgtgtgaaagacaaaaaaaaannantgcaatactctttttttaatgataaaacctgtgaa gtttcccaaagcaggttttaaaaggaaaaaaaggaaaagcaaaaaggttgctgttctcac tcccatctcatttagtgcatgtcttaattcgggattagtaatgaattggaggatcattag acatttctaggaacc > 37788_at HG-U95AV2 catgaatcacatagagcagtggagttttanccaagtggtgtgtgtggtttttgtttttta ctatgcaaagatgggaaatgcacaaacttttcaaagactagtgtctgaagaactttacaa acaatacttgaaccctttctttaaagttatcccatcatgttttatagtcattgttgcttc cattgttagtttccattttcaagtgctttgtaattttttaagtgcactacctgaaatttt gtttgaaattaataaattcattcgtatcttgttggctgcctatgaatggagattcagtag tcattgtatgcatctttaagtcaaatgtgtattaaaactttcgttaacgtanaaaaaaaa aaannnannnnnnaannnnnnnnnnnnnncnnccttttctgtttcctcttgtagtgctga tta > 38393_at HG-U95Av2 cccaaggtgggacttggagaatattttgcnttggcatatgtttggtctgaatggtgtagt tgctggttccctagagaggaaaaggtggcnnggcccnnnnnnnnnnnnnnnnnnnnctta atttccagttgaaaccctagtagaattgtgaatgaaaacctcaaggttgagncccctctg ccaagcagcagagctagtagaaggggatgcaggggcaaagcactcagttgccaagcaagg aggagagatgtacgtgggctgtgtggcagtccccacaccctgccctg gcttcttcaggtt 131 - 98677.doc 200533758 atcgcaccactatggaatcctttgcagaatggtactcatataatggtttaaaacaacaca ttcataattgactctgtgcaggatgtcactcaatcagtttgggtttgcttt > 38510_at HG-U95AV2 gtcctcccatattggcaaagataaagcaattgacaaaaatggaattcttgttcaatactg gcaggagtgaaaattggtagaacctttntagaaggcnattnggcnannatgtatgnaaan cntaaatgtngatacncctttacccagcagtttgtttnggaatttatcctaatgaataaa agttgnccnagncntcnaaacangannnnnaannnanatttcnatgatgtttatgatatt aaaacattggnaacaactgaaacatccntcagtaaaagatggattaaataaattccatgc nagttgtcatttaaaaatatttagatatatgtttattgctatggatatatgttcccaaaa tattattgaatcaaaaagtagactacaggatatatgttgaatatgagctcatttataaca ttgaatattttaagataatgtatgtttcatagagagatcttcaccaaatgttaaggattt > 38717_at HG-U95AV2 tacaaggttgccacacctagttctgcccagctttatgtcttttattccagtattccacca aagtttgttttcctgncattccagttctcaagtcttaagnataaagattgtacttgacag tttagtatatccataaaactatttgaggtggttaaggttcttgggttcattttccttaat actttgctgaatattgtagattgtaggcdatgdaaaagtctactaaattdggeiaaacctl: gaataattaggtatcctaggtaagagcccctaaacatcaagcaatctgtgagtctgtaaa

gaaataaatattttttggattattcttatctaattccacccctgttggaagatgatttct ttgttctttgcaactatggaagctg >387 49__at HG-U95Av2 ggcggcagcacagcacctgcacgaacacccgccgaaactgctgcgaggacaccgtgtaca ggagcgggttgatgaccgagctgaggtagaaaaacgtctccngagaaggggaggaggatc atgtacgcccggaagtaggacctcgtccagtcgtgcttgggtttgnccgcagccatgatc ctccgaatctggttgggcatccagcatacggccaatgtcacaacaatcagccctgggcag acacgagcaggagggagagacagagaaaagaaaaacacagcatgagaacacagtaaatna ataaaaccataaaatatttagcccctctgttctgtgcttactggccaggaaatggtacca atttttcagtgttggacttgacagcttcttttgccacaagcaagagagaatttaacactg tttcaaacccgggggagttggctgtgttaaagaaagaccattaaatgctttagacagtgt aaaaaaaaaaaaanannnnnnnnaannnnaaaaaaannnnnnnattggtgtttgtttgcg tatccngaaagcagntcatgttatccataaatctggttttg >3 8 972_at HG-U95Av2 cgttagtaaccatttagtgacaaaggattaaaacatccatctggatgttaattttgaaga tgtaaattatatgttgtttaaatttttccaggcatctgaaaaccttatctgctagacaat gtaagattcacacagagttatctngggattctgattttttaaatagtacatatcattaaa ccattttctctaaatgtaagaagagcagaaaaaatcttataagattatcagatttttcta atgacacagaaatgtaagaaaaaaatccctttatattgaaaaaagatgcagtcaaagtct tttcagacatgcccaaactttgagaatttcttcaaccatctaatgctataaagatttttg ttcttcctgttcacaaccagttgtataacagaaatactagctactgttttccttcctgtg t >39582_at HG-U95Av2 ggccacaaatggagggattgtcctttcaagcaccacagcttcagataaaattagtacttt caaatattgtccactttaacttaaaaaattctagagggattatattggagactcaactgc ccttnggttttagtttataaaatggcctagtactgtggaattttaattttagaaagtctt agcatcagatcataaacattcattaaaagaactcacatcccatctgaaacttcccagggg agttgggattcttagtagattggtagaaaggggctcattttctactgcatttcccatttt tggtatcttgttcagcatgttttatttttatttcttgtctgcagaacatcctatatttat gagaacattctttaagaagaccaccacatagaataccccttcctatcagctcgctctgat ttagccttaat >39597_at HG-U95Av2 caaacataacggatgtaaggcagaaagtgatcggagaaggaatgagaaantgtgcgtgat gttaatgaaaagtcatatgcagctagagcagacccaggaaagctttctggaagagattgc atctgaggaaattcaggaaggatctttgtagattggggggagattctaaattgaaggggt gatngggtgaggggccagagggaagtctgctgtgttctcatgtaggatgtcagccctccc tgcaacttctctttttggccaatgtcttttcactttcctgaccctttagaatcatcccca gccagacgcaatcatggaagttgccttattgtcactggttaagaacttggcgaga 132- 98677.doc 200533758 >39602一at HG-U95Av2 gggtctacattaatcttccagtactccttgctgatgctgtgttatgtgtcatctaacaga aatgactcctttgaaataagtaaatctttggctttttgttnnnnnnnnnnnnnnnnaagc aaaacaaacaaacaaaaacaaattttaagaacacaacaaaaaagatttgacttccgaata gaatgttttctttaagaggcatgaaaagcaactattgttgtgttacagtgttaaaaatat tcagttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnntgtggcatctgaacttttataaaggtttccttgtgc caaataagtgcaaagatttaatttactattaaaaaccataagcatatgttatagttccag aagaattattttgtcatcaagtgattttgatctttagtgtcaatatttatatttagatta atttttataaatgaaaatattttaatggtttaagaaaatgaggacaacaggataatatct ttgatgacttctgaaagttatgcttccctt >39827__at HG-U95Av2 acgtgctcctcagagcagccggagggaggggggaggtcggaggtcgtggaggtggtttgt gtatcttactggtctgaagggaccaagtgtgtttgttgtttgttttgtatcttgtttttc tgatcggagcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnannnnnnnnnnnaa nnnnagnnnnggnngggnnnnnngnnnnggatcacttgggatctttgacacttgaaaaatgaaataaatattttttggattattcttatctaattccacccctgttggaagatgatttct ttgttctttgcaactatggaagctg > 387 49__at HG-U95Av2 ggcggcagcacagcacctgcacgaacacccgccgaaactgctgcgaggacaccgtgtaca ggagcgggttgatgaccgagctgaggtagaaaaacgtctccngagaaggggaggaggatc atgtacgcccggaagtaggacctcgtccagtcgtgcttgggtttgnccgcagccatgatc ctccgaatctggttgggcatccagcatacggccaatgtcacaacaatcagccctgggcag acacgagcaggagggagagacagagaaaagaaaaacacagcatgagaacacagtaaatna ataaaaccataaaatatttagcccctctgttctgtgcttactggccaggaaatggtacca atttttcagtgttggacttgacagcttcttttgccacaagcaagagagaatttaacactg tttcaaacccgggggagttggctgtgttaaagaaagaccattaaatgctttagacagtgt aaaaaaaaaaaaanannnnnnnnaannnnaaaaaaannnnnnnattggtgtttgtttgcg tatccngaaagcagntcatgttatccataaatctggttttg > 3 8 972_at HG-U95Av2 cgttagtaaccatttagtgacaaaggattaaaacatccatctggatgttaattttgaaga tgtaaattatatgttgtttaaatttttccaggcatctgaaaaccttatctgctagacaat gtaagattcacacagagttatctngggattctgattttttaaatagtacatatcattaaa ccattttctctaaatgtaagaagagcagaaaaaatcttataagattatcagatttttcta atgacacagaaatgtaagaaaaaaatcc ctttatattgaaaaaagatgcagtcaaagtct ttcttcctgttcacaaccagttgtataacagaaatactagctactgttttccttcctgtg t & gt tttcagacatgcccaaactttgagaatttcttcaaccatctaatgctataaagatttttg; 39582_at HG-U95Av2 ggccacaaatggagggattgtcctttcaagcaccacagcttcagataaaattagtacttt caaatattgtccactttaacttaaaaaattctagagggattatattggagactcaactgc ccttnggttttagtttataaaatggcctagtactgtggaattttaattttagaaagtctt agcatcagatcataaacattcattaaaagaactcacatcccatctgaaacttcccagggg agttgggattcttagtagattggtagaaaggggctcattttctactgcatttcccatttt tggtatcttgttcagcatgttttatttttatttcttgtctgcagaacatcctatatttat gagaacattctttaagaagaccaccacatagaataccccttcctatcagctcgctctgat ttagccttaat > 39597_at HG-U95Av2 caaacataacggatgtaaggcagaaagtgatcggagaaggaatgagaaantgtgcgtgat gttaatgaaaagtcatatgcagctagagcagacccaggaaagctttctggaagagattgc atctgaggaaattcaggaaggatctttgtagattggggggagattctaaattgaaggggt gatngggtgaggggccagagggaagtctgctgtgttctcatgtaggatgtcagccctccc tgcaacttctctttttggccaatgtcttttcactttcctgaccctttagaatcatcccca gccagacgcaatcatggaagttgccttattgtcactggttaagaacttggcga ga 132- 98677.doc 200533758 > 39602 a at HG-U95Av2 gggtctacattaatcttccagtactccttgctgatgctgtgttatgtgtcatctaacaga aatgactcctttgaaataagtaaatctttggctttttgttnnnnnnnnnnnnnnnnaagc aaaacaaacaaacaaaaacaaattttaagaacacaacaaaaaagatttgacttccgaata gaatgttttctttaagaggcatgaaaagcaactattgttgtgttacagtgttaaaaatat tcagttnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnntgtggcatctgaacttttataaaggtttccttgtgc caaataagtgcaaagatttaatttactattaaaaaccataagcatatgttatagttccag aagaattattttgtcatcaagtgattttgatctttagtgtcaatatttatatttagatta atttttataaatgaaaatattttaatggtttaagaaaatgaggacaacaggataatatct ttgatgacttctgaaagttatgcttccctt > 39827__at HG-U95Av2 acgtgctcctcagagcagccggagggaggggggaggtcggaggtcgtggaggtggtttgt gtatcttactggtctgaagggaccaagtgtgtttgttgtttgttttgtatcttgtttttc tgatcggagcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnannnnnnnnnnnaa nnnnagnnnnggnngggnnnnnngnnnnggatcacttgggatctttgacacttgaaaaat

tacacctggcagctgcgtttaagccttcccccatcgtgtactgcagagttgagctggcag gggaggggctgagagggtgggggctggaacccctccccggnnnnnnnnnnnnnnnnnnct tccatctagaactgtttacatgaagataagatactcactgttcatgaatacacttgatgt tcaagta >39837_s_at HG-U95Av2 cctagttctcacgaggaccctttcttgcccacagtttcgagaggcccgtgccatgagacc gcctggggtgagcaaggcgacctgnnctgctgccngaaggtttggccgccgcgggacacc tgtttccttcccncagtgtctgcgtccgcacagcatacccagctcggacctcctaggaca gagactcagcgaacccttgctgggaaccgctgagctgaagttcttggaaggctcccaccc aggtgccccgttggaaagcagatat >40239_g_at HG-U95Av2 tataagtatgcaacagtcagccgggggaagataaaggtacattataaaacacacattaat gcatttaataaatatatattatctatcaaaagtgagccttagctcttcatcagttaataa aaagcacctgctgagaactcctgtaagctggtatcatcattgcatcattggattataaaa gccacaatgctccctttcaacttggggtttg >40472_at HG-U95Av2 ttgctgaagagcaagcagagggtccnnnncgcctgctgtacaannnnnnnnnnnnnnnca t c nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnaggcctctccctctgtcagttccagaacttctccctccatg acccactctatgggaaactcttcagcacctacctgcgccccccacacacctctcgaggca cctcccagacaccaaatgcctcatccccaggcaaccccactgctctggccaatgggactg tgcaagcacccaagcagaagggagactgagtgcctcagectctcaccccctcctcctcag ggcagcgctaggggcctcccctatgcctcagccccatctctgctcctgtttgaattttg >40642_at HG-U95Av2 taagcccttgatgacttattgcatgatacagtannnnnnnnnnnnnnnnnnntaaataca tgaaaagcagtgtaagctagtgacactaaagccagtcttgtattactgtatttttgacag aatggttttgaaaactgtgctacagggactgatgtggcaaatatatctctttatgcagaa ggaagtctttttttttcntttttttttttttaagaagtatggctttttatgcatccttca tcgagggcattgaagttgcatggactgataaaagttgatgcaaaacaagaaagaaacaaa caaaaaaaaaaaaccagcaaaatgtttaccaaaaaactcaaacaaatgageagtgeetgt tcaatttcacagtctctgttgagttcagttgtaaatatgtttcaaatgacattttcttgg gaaaaaaaatctctacaacattgtagaatgtgaggggtaactacatcccaggcatag >40855_at HG-U95Av2 ctcatgtatttatgcctaatgtaagctgacttttaaaaagctttcttttgttgcatgccc tgtgcaggcatctgtattgtacatgcatgcctttcgtcctgttttcctgtataaagttag tgaacaaagaaatatttttgcctagttcatgttgccaagcaatgcatattttttaaattt gtcatatatggaaagagcatgtttgttacatgtaaaagctttactgatatacagatatac taatgtttgaagatgctgttctttgcaagtgtacagttttcannnnnnnnnnnnnnnnnn -133- 98677.doc 200533758 ncacccttgtggtttaaacttgctacaatgtatttattattcatttcctcccatgtaact aagaatcatggctat >4122 9__at HG-U95Av2 caacttttgtaggactgtgtgtttctttagatacatttagtacaactgtaggtgacgagt agtcagttattgcttgctagctacnnnnnnnnnnnnnnnnnnnnnnnnacttttggcatt ttgtcctcatgggccataaatacagaaccttgtattttaattaaanttttttncaaaagg anggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttagcagtaggatgtattatacgaca gttacttaatttctagagttcaggcctctgggatcaaccccagactgggccagaatgtta gtgaaggttttattgtgcccggttggaggataacgttctttgggtactttttgtgggttg caaatgaactcaattgccacaagttttaaactggtgtaaatcaagcttgacttaatgtga ttgttactgttatatccagcctatactgctagcagctgctcatactgcagtcaattactg gaagcggatat >41690_at HG-U95AV2 ttgccctggtgagacccataccattnnnnnnnnnnnnnnnnnnncttaaagtccagtgtt ggctgttagtgtatttgatattctgcctgtctcctcatggttgaaatatgtctgaagaat agcagcataatctctrggctgtttatacttttttaaactttcctgtgttgtaaatattgt atacttttggtgattccagctatgtaacctctatgctctgtaaggtgattatttgtatattacacctggcagctgcgtttaagccttcccccatcgtgtactgcagagttgagctggcag gggaggggctgagagggtgggggctggaacccctccccggnnnnnnnnnnnnnnnnnnct tccatctagaactgtttacatgaagataagatactcactgttcatgaatacacttgatgt tcaagta > 39837_s_at HG-U95Av2 cctagttctcacgaggaccctttcttgcccacagtttcgagaggcccgtgccatgagacc gcctggggtgagcaaggcgacctgnnctgctgccngaaggtttggccgccgcgggacacc tgtttccttcccncagtgtctgcgtccgcacagcatacccagctcggacctcctaggaca gagactcagcgaacccttgctgggaaccgctgagctgaagttcttggaaggctcccaccc aggtgccccgttggaaagcagatat > 40239_g_at HG-U95Av2 tataagtatgcaacagtcagccgggggaagataaaggtacattataaaacacacattaat gcatttaataaatatatattatctatcaaaagtgagccttagctcttcatcagttaataa aaagcacctgctgagaactcctgtaagctggtatcatcattgcatcattggattataaaa gccacaatgctccctttcaacttggggtttg > 40472_at HG-U95Av2 ttgctgaagagcaagcagagggtccnnnncgcctgctgtacaannnnnnnnnnnnnnnca t c nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnaggcctctccctctgtcagttccagaacttctccctccatg acccactctatgggaaactcttcagcacctacctgcgccccccacacacctctcgaggca cctcc cagacaccaaatgcctcatccccaggcaaccccactgctctggccaatgggactg tgcaagcacccaagcagaagggagactgagtgcctcagectctcaccccctcctcctcag ggcagcgctaggggcctcccctatgcctcagccccatctctgctcctgtttgaattttg > 40642_at HG-U95Av2 taagcccttgatgacttattgcatgatacagtannnnnnnnnnnnnnnnnnntaaataca tgaaaagcagtgtaagctagtgacactaaagccagtcttgtattactgtatttttgacag aatggttttgaaaactgtgctacagggactgatgtggcaaatatatctctttatgcagaa ggaagtctttttttttcntttttttttttttaagaagtatggctttttatgcatccttca tcgagggcattgaagttgcatggactgataaaagttgatgcaaaacaagaaagaaacaaa caaaaaaaaaaaaccagcaaaatgtttaccaaaaaactcaaacaaatgageagtgeetgt tcaatttcacagtctctgttgagttcagttgtaaatatgtttcaaatgacattttcttgg gaaaaaaaatctctacaacattgtagaatgtgaggggtaactacatcccaggcatag > 40855_at HG-U95Av2 ctcatgtatttatgcctaatgtaagctgacttttaaaaagctttcttttgttgcatgccc tgtgcaggcatctgtattgtacatgcatgcctttcgtcctgttttcctgtataaagttag tgaacaaagaaatatttttgcctagttcatgttgccaagcaatgcatattttttaaattt gtcatatatggaaagagcatgtttgttacatgtaaaagctttactgatatacagatatac taatgtttgaagatgctgttctttgcaagtgtacagttttcannnnnn nnnnnnnnnnnn -133- 98677.doc 200533758 ncacccttgtggtttaaacttgctacaatgtatttattattcatttcctcccatgtaact aagaatcatggctat > 4122 9__at HG-U95Av2 caacttttgtaggactgtgtgtttctttagatacatttagtacaactgtaggtgacgagt agtcagttattgcttgctagctacnnnnnnnnnnnnnnnnnnnnnnnnacttttggcatt ttgtcctcatgggccataaatacagaaccttgtattttaattaaanttttttncaaaagg anggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnttagcagtaggatgtattatacgaca gttacttaatttctagagttcaggcctctgggatcaaccccagactgggccagaatgtta gtgaaggttttattgtgcccggttggaggataacgttctttgggtactttttgtgggttg caaatgaactcaattgccacaagttttaaactggtgtaaatcaagcttgacttaatgtga ttgttactgttatatccagcctatactgctagcagctgctcatactgcagtcaattactg gaagcggatat > 41690_at HG-U95AV2 ttgccctggtgagacccataccattnnnnnnnnnnnnnnnnnnncttaaagtccagtgtt ggctgttagtgtatttgatattctgcctgtctcctcatggttgaaatatgtctgaagaat agcagcataatctctrggctgtttatacttttttaaactttcctgtgttgtaaatattgt atacttttggtgattccagctatgtaacctctatgctctgtaaggtgattatttgtatat

agcaacatggcccagtgatattatatagtttcccaatggagaggttattgagtaaccttt gcattagtttaaacactaccagaagaatgctgagccaactataaacactcaattttgtat gttttccaaattgtacttattactgcttttgatactgtattacgtgccaatagtttccca atcacatagcaggcaaga >41710_at HG-U95Av2 ccataattgtttagccatgtgagtttcaggttggtacacgttcagacagaactgctgtat cacattccaattttgaatagccagtgagcaatcaagtgtagagaaatgataaatggccta agaagnnnnnnnnnnnnnnnnnnnnatgctcttcctagtagcttaataggccacaagcta gtttctgttgcactctgaaataaaatatgctttaaaaatgtagggaacagtgcttagaaa agcaaaaactaggtgtgtcattgaaataataggcataaaaattaaatgttacataagaac actatttggaaagagggtccttttaaaaactgaatttgtactaaatcagatttgccatgt ccagtacagaataatttgtacttagtatttgcagcagggtttgtctttgtgaattc >41735_at HG-U95Av2 gctctacactccagggcatcttgacccagccgaaaaagttgaagatgctcaccccaagtt at gg t g t gc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnncactgcaaaagtgaactgcatggtgatggccgaccagaa ccaggtgtgggttggctcggaagactccgtcatctacatcatcaacgtccacagcatgtc ctgcaacaagcagctcacagcccactgctccagtgtcacggatttgattgtgcaggacgg acaggaggcacccagcaacgtgtactcgtgcagcatggacggcatggtgctggtgtggaa tgtgagcacactgcaggtgacca >41837_at HG-U95Av2 tcaccaatgcatatgaagagtatgcttggggaagagcttaggaatggggtgggcatggga ntgctgggtagncagccnnttnnagcaaatctgcatcnntnctcttatttcnnngacctt tntnc c angtnnc c c a gt ccnnntnnnnnnnnnnnnnnnnnnnnnnnnnnnntnc 111 at actatttaatcttttgcagaaaccttactattataacttgctactctccagataccaatt c 11 c nnnnnnnnnnnnnnnnnnnnnnnnnnnt gtcttactgatgttttcatgatcaactt gtaaatgtaagcagttgacttcataaaaggtattttaactattcttggagtcctttgcta cccaagcacctggtttcaccatgcgatcactgacttctctacag >717_at HG-U95AV2 gttcggatttgactgcctgtatatgttttgtgaaatggtcctgtttttgggtaggtgaca cgtggactctagtatgtaaatgttacttgaatctgtgcttcataatagtgtgtggcatgt atgtgcagactcttggatgctttatgcctgcgcaccaggagccctgtcctcacgttccca ggagggcggcttcacccttcgtaaccaggagacaaggcggccatggatttgcccttgatt ctattttgctaatggaagatagaaaggagagaaggtttttttttttttttaacattctga agatggtgctgtgtcaagaaggaccttttttttcccctctcccctattttttaagtacct tggaggaggagaggttggtgacatgcatggtggggatctatggcctctggtgctt 134- 98677.doc 200533758 【圖式簡單說明】 表a歹J舉基因的轉錄本，其含量在内皮細胞中係由、火 症，I體TNF-α、IL-I/S^ IL_8調節，在那裡基因具有先 前所認定的功能。 表lb歹j舉基因或ests的轉錄本，其含量在内皮細胞中 係由炎症介體TNF-α、IL-1/3和IL-8調節，在那裡基因 /ESTs不具有先前所認定的功能。 表2a提供在表1 a中提及之每個探針的核酸序列。 ® 表2b提供在表lb中提及之每個探針的核酸序列。agcaacatggcccagtgatattatatagtttcccaatggagaggttattgagtaaccttt gcattagtttaaacactaccagaagaatgctgagccaactataaacactcaattttgtat gttttccaaattgtacttattactgcttttgatactgtattacgtgccaatagtttccca atcacatagcaggcaaga > 41710_at HG-U95Av2 ccataattgtttagccatgtgagtttcaggttggtacacgttcagacagaactgctgtat cacattccaattttgaatagccagtgagcaatcaagtgtagagaaatgataaatggccta agaagnnnnnnnnnnnnnnnnnnnnatgctcttcctagtagcttaataggccacaagcta gtttctgttgcactctgaaataaaatatgctttaaaaatgtagggaacagtgcttagaaa agcaaaaactaggtgtgtcattgaaataataggcataaaaattaaatgttacataagaac actatttggaaagagggtccttttaaaaactgaatttgtactaaatcagatttgccatgt ccagtacagaataatttgtacttagtatttgcagcagggtttgtctttgtgaattc > 41735_at HG-U95Av2 gctctacactccagggcatcttgacccagccgaaaaagttgaagatgctcaccccaagtt at gg t g t gc nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnncactgcaaaagtgaactgcatggtgatggccgaccagaa ccaggtgtgggttggctcggaagactccgtcatctacatcatcaacgtccacagcatgtc ctgcaacaagcagctcacagcccactgctccagtgtcacggatttgattgtgcaggacgg acaggaggcacccagcaa cgtgtactcgtgcagcatggacggcatggtgctggtgtggaa tgtgagcacactgcaggtgacca > 41837_at HG-U95Av2 tcaccaatgcatatgaagagtatgcttggggaagagcttaggaatggggtgggcatggga ntgctgggtagncagccnnttnnagcaaatctgcatcnntnctcttatttcnnngacctt tntnc c angtnnc c c a gt ccnnntnnnnnnnnnnnnnnnnnnnnnnnnnnnntnc 111 at actatttaatcttttgcagaaaccttactattataacttgctactctccagataccaatt c 11 c nnnnnnnnnnnnnnnnnnnnnnnnnnnt gtcttactgatgttttcatgatcaactt gtaaatgtaagcagttgacttcataaaaggtattttaactattcttggagtcctttgcta cccaagcacctggtttcaccatgcgatcactgacttctctacag > 717_at HG-U95AV2 gttcggatttgactgcctgtatatgttttgtgaaatggtcctgtttttgggtaggtgaca cgtggactctagtatgtaaatgttacttgaatctgtgcttcataatagtgtgtggcatgt atgtgcagactcttggatgctttatgcctgcgcaccaggagccctgtcctcacgttccca ggagggcggcttcacccttcgtaaccaggagacaaggcggccatggatttgcccttgatt ctattttgctaatggaagatagaaaggagagaaggtttttttttttttttaacattctga agatggtgctgtgtcaagaaggaccttttttttcccctctcccctattttttaagtacct tggaggaggagaggttggtgacatgcatggtggggatctatggcctctggtgctt 134- 98677.doc 200533758 [FIG formula simply [Description] Table a 歹 J exemplified gene transcripts whose contents are regulated in endothelial cells by Pyrex, I-body TNF-α, IL-I / S ^ IL_8, where the genes have previously identified functions. Table lb 歹 j transcripts of genes or ests whose content is regulated by inflammatory mediators TNF-α, IL-1 / 3, and IL-8 in endothelial cells, where genes / ESTs do not have previously identified functions . Table 2a provides the nucleic acid sequence of each probe mentioned in Table 1a. ® Table 2b provides the nucleic acid sequence of each probe mentioned in Table lb.

98677.doc -135 - 200533758 序列表 <11〇>英商劍橋大學王業技術服務有限公司 <使用内皮細胞的表現輪靡，評估組織炎症反應的方法 <130>AHB/CP6270680 <140〉094101217 <141> 2005-01-1498677.doc -135-200533758 Sequence Listing < 11〇 > Anglo-Commercial University of Cambridge Wangye Technology Services Co., Ltd. < Methods for Evaluating Tissue Inflammation Response Using Endothelial Cells' Outrageous Performance < 130 > AHB / CP6270680 < 140〉 094101217 < 141 > 2005-01-14

<150〉 GB 0400976.7 <151> 2004-01-16 <160> 520 <170> Patentln version 3.1 <210> 1 <211> 247 <212> DNA <213>人類< 150> GB 0400976.7 < 151 > 2004-01-16 < 160 > 520 < 170 > Patentln version 3.1 < 210 > 1 < 211 > 247 < 212 > DNA < 213 > human

<223> Probe 1736_at HG-U95Av2 <400> 1 agtaaacccc aagcaggcac tgcccgccca caggatgtga accgcagaga ccaacagagg aatccaggca cctctaccac gccctcccag cccaattctg cgggtgtcca agacactgag atgggcccat gccgtagaca tctggactca gtgctgcagc aactccagac tgaggtctac cgaggggctc aaacactcta cgtgcccaat tgtgaccatc gaggcttcta ccggaagcgg cagtgcc 98677.doc 60 120 180 240 247 200533758 <210〉 2 <211> 412 <212〉 DNA <213> 人類 <220〉 <223〉 Probe 34021—at HG-U95Av2 <220> <221> misc 一feature <222〉 (88)..(197) <223〉 n 為 a，g，c 或 t <220〉 <221> misc-feature <222〉 (277)..(344) <223> n 為 a，g，c 或 t <400〉 2≪ 223 > Probe 1736_at HG-U95Av2 < 400 > 1 agtaaacccc aagcaggcac tgcccgccca caggatgtga accgcagaga ccaacagagg aatccaggca cctctaccac gccctcccag cccaattctg cgggtgtcca agacactgag atgggcccat gccgtagaca tctggactca gtgctgcagc aactccagac tgaggtctac cgaggggctc aaacactcta cgtgcccaat tgtgaccatc gaggcttcta ccggaagcgg cagtgcc 98677.doc 60 120 180 240 247 200533758 < 210〉 2 < 211 > 412 < 212〉 DNA < 213 > Human < 220〉 < 223〉 Probe 34021-at HG-U95Av2 < 220 > < 221 > misc-feature < 222> (88 ): (197) < 223〉 n is a, g, c or t < 220〉 < 221 > misc-feature < 222〉 (277) .. (344) < 223 > n is a, g, c or t < 400〉 2

60 120 180 240 300 360 caagaatccc aaactcacca ggatgctcac atttaagttt tacatgccca agaaggccac agaactgaaa catcttcagt gtctagannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnagg gatetgaaac aacattcatg tgtgaatatg ctgatgagac agcaaccatt gtagaatttc tgaacagatg gattacnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncttcta tttatttaaa tatttaaatt ttatatttat tgttgaatgt atggtttgct acctattgta ac 9867i.doc 412 200533758 <210〉 3 <211> 384 <212〉 DNA <213>人類 <220> <223〉 Probe 35061—at HG-U95Av2 <220> <221> misc_feature <222〉 （78)..(78) <223> η 為 a，g，c 或 t60 120 180 240 300 360 caagaatccc aaactcacca ggatgctcac atttaagttt tacatgccca agaaggccac agaactgaaa catcttcagt gtctagannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnagg gatetgaaac aacattcatg tgtgaatatg ctgatgagac agcaaccatt gtagaatttc tgaacagatg gattacnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncttcta tttatttaaa tatttaaatt ttatatttat tgttgaatgt atggtttgct acctattgta ac 9867i. doc 412 200533758 < 210〉 3 < 211> (78) .. (78) < 223 > η is a, g, c or t

<400> 3 ggagtcaagc tttcatgcaa acattcttat tgtactatga caaattagca gaagcaatta tagcaatatc ccttataagt atacacantt gcatcatttg aaaaaattat gcaccggtct ggatatgtgt ttggacacat caaaagcatc ctttccccaa gtttgtttta acgctatggg taatttgatg gtttactgta ttga tatgtgtcgt atatcatgta taaccaattc atactggcaa tttttcaact ctttttgttt aaagcattcc gcacatcaat attaaatgta cagtgcacat tttattcatt tgatccgttt tcaaacattt atgtagggaa attcataaaa atttcataac gagatgtttt gtataaatga 60 120 180 240 300 360 384 <210> 4 <211> 344 <212〉 DNA <213>人類 <220〉 <223> Probe 36444_s—at HG-U95Av2 98677.doc 200533758 <400> 4 ttccatgcta ctagtgctga ctgctgcatc tcctacaccc cacgaagcat cccgtgttca ctcctggaga gttactttga aacgaacagc gagtgctcca agccgggtgt catcttcctc accaagaagg ggcgacgttt ctgtgccaac cccagtgata agcaagttca ggtttgcatg agaatgctga agctggacac acggatcaag accaggaaga attgaacttg tcaaggtgaa gggacacaag ttgccagcca ccaactttct tgcctcaact accttcctga attatttttt taagaagcat itaitcttgt gttctggatt iagagcaatt catc≪ 400 > 3 ggagtcaagc tttcatgcaa acattcttat tgtactatga caaattagca gaagcaatta tagcaatatc ccttataagt atacacantt gcatcatttg aaaaaattat gcaccggtct ggatatgtgt ttggacacat caaaagcatc ctttccccaa gtttgtttta acgctatggg taatttgatg gtttactgta ttga tatgtgtcgt atatcatgta taaccaattc atactggcaa tttttcaact ctttttgttt aaagcattcc gcacatcaat attaaatgta cagtgcacat tttattcatt tgatccgttt tcaaacattt atgtagggaa attcataaaa atttcataac gagatgtttt gtataaatga 60 120 180 240 300 360 384 < 210 > 4 < 211> cccgtgttca ctcctggaga gttactttga aacgaacagc gagtgctcca agccgggtgt catcttcctc accaagaagg ggcgacgttt ctgtgccaac cccagtgata agcaagttca ggtttgcatg agaatgctga agctggacac acggatcaag accaggaaga attgaacttg tcaaggtgaa gggacacaag ttgccagcca ccaactttct tgcctcaact accttcctga attatttttt taagaagcat itaitcttgt gttctggatt iagagcaatt catc

<210〉 5 <211> 447 <212〉 DNA <213>人類 <220> <223〉 Probe 36782—s—at HG-U95Av2 <220> <221> misc_feature <222〉 （270).,(290)< 210〉 5 < 211 > 447 < 212> DNA < 213 > human < 220 > < 223〉 Probe 36782—s-at HG-U95Av2 < 220 > < 221 > misc_feature < 222〉 (270)., (290)

<223> n 為 a，g，c 或 t <400> 5 ttcttccaat ctcctgcgtg aaacgtcacc ccagagatgg ccatcctgca atgacacctg cccgccgggg gtcccctgat ccagcaatcg gcctcctcct gaagcagtcc tcacgtgctc tgctctaccc gaagtgagca gaccacggan acccagcgcc gccaaggagc acccaagacc aaactgccgc nnnnnnnnnn tgcgcagggg tcgaggcgtt ccgcccacgg aagtctgcag nnnnnnnnnn cctgcctgcc cagggaggcc gggcgccccc cccggcgcca cgaaaatctc 98677.doc -4- 200533758 tcggttccac gtccccctgg ggcttctcct gacccagtcc ccgtgccccg cctccccgaa acaggctact ctcctcggcc ccctccatcg ggctgaggaa gcacagcagc atcttcaaac atgtacaaaa tcgattggct ttaaaca <210〉 6 <211> 122 <212〉 DNA <213〉人類≪ 223 > n is a, g, c or t < 400 > 5 ttcttccaat ctcctgcgtg aaacgtcacc ccagagatgg ccatcctgca atgacacctg cccgccgggg gtcccctgat ccagcaatcg gcctcctcct gaagcagtcc tcacgtgctc tgctctaccc gaagtgagca gaccacggan acccagcgcc gccaaggagc acccaagacc aaactgccgc nnnnnnnnnn tgcgcagggg tcgaggcgtt ccgcccacgg aagtctgcag nnnnnnnnnn cctgcctgcc cagggaggcc gggcgccccc cccggcgcca cgaaaatctc 98677. doc -4- 200533758 tcggttccac gtccccctgg ggcttctcct gacccagtcc ccgtgccccg cctccccgaa acaggctact ctcctcggcc ccctccatcg ggctgaggaa gcacagcagc human & > 212> 212; lta> 210

<220> <223> Probe 37319_at HG-U95Av2 <400〉 6 cccaagaagg tctggcaaag tcaggctcag ggagactctg ccctgctgca gacctcggtg tggacacacg ctgcatagag ctctccttga aaacagaggg gtctcaagac attctgccta cc <210> 7 <211〉 235 <212> DNA <213>人類 <220〉 <223〉 Probe 431一at HG-U95Av2 <400〉 7 actctaagtg attagtaatc caattttgtc gcattcaagg aacctgttaa cacgtgttga agtacctctc tccaaggtct gatcattgct tctagaaccg ttagaaaaac acaatgaaaa tacgctgtac ttgaaattat agaagggtga ctgcatcagc tcctgcaagc gaagagatgt 98677.doc 200533758 ctgaatccag aatcgaaggc catcaagaat ttactgaaag cagttagcaa ggaaa <210> 8 <211> 607 <212〉 DNA <213>人類 <220〉 <223〉 Probe 1006_at HG-U95Av2 <400〉 8 ctgaggaacc cctggtgccc acaaaatctg ttccttcggg atctgagatg ccagccaagt gtgatcctgc tttgtccttc gatgccatca gcactctgag gggagaatat ctgttcttta aagacagata tttttggcga agatcccact ggaaccctga acctgaattt catttgattt ctgcattttg gccctctctt ccatcatatt tggatgctgc atatgaagtt aacagcaggg acaccgtttt tatttttaaa ggaaatgagt tctgggccat cagaggaaat gaggtacaag caggttatcc aagaggcatc cataccctgg gttttcctcc aaccataagg aaaattgatg cagctgtttc tgacaaggaa aagaagaaaa catacttctt tgcagcggac aaatactgga gatttgatga aaatagccag tccatggagc aaggcttccc tagactaata gctgatgact ttccaggagt tgagcctaag gttgatgctg tattacaggc atttggattt ttctacttct tcagtggatc atcacagttt gagtttgacc ccaatgccag gatggtgaca cacatattaa agagtaa <210> 9 <211> 109 98677.doc 235< 220 > < 223 > Probe 37319_at HG-U95Av2 < 400〉 6 cccaagaagg tctggcaaag tcaggctcag ggagactctg ccctgctgca gacctcggtg tggacacacg & 212 &ct; 212 &ct; 210 < 212 < 212 < 212 human < 220> < 223> Probe 431 a at HG-U95Av2 < 400> 7 actctaagtg attagtaatc caattttgtc gcattcaagg aacctgttaa cacgtgttga agtacctctc tccaaggtct gatcattgct tctagaaccg ttagaaaaac acaatgaaaa tacgctgtac ttgaaattat agaagggtga ctgcatcagc tcctgcaagc gaagagatgt 98677.doc 200533758 ctgaatccag aatcgaaggc catcaagaat ttactgaaag cagttagcaa ggaaa < 210 > 8 < 211 > 607 < 212〉 DNA < 213 > human < 220> < 223〉 Probe 1006_at HG-U95Av2 < 400> 8 ctgaggaacc cctggtgccc acaaaatctg ttccttcggg atctgagatg ccatgtcggtcgcctggtctcctcctggtcgcctggtcgcctcc tttttggcga agatcccact ggaaccctga acctgaattt catttgattt ctgcattttg gccctctctt ccatcatatt tggatgctgc atatgaagtt aacagcaggg acaccgtttt tatt tttaaa ggaaatgagt tctgggccat cagaggaaat gaggtacaag caggttatcc aagaggcatc cataccctgg gttttcctcc aaccataagg aaaattgatg cagctgtttc tgacaaggaa aagaagaaaa catacttctt tgcagcggac aaatactgga gatttgatga aaatagccag tccatggagc aaggcttccc tagactaata gctgatgact ttccaggagt tgagcctaag gttgatgctg tattacaggc atttggattt ttctacttct tcagtggatc atcacagttt gagtttgacc ccaatgccag gatggtgaca cacatattaa agagtaa < 210 > 9 < 211 > 109 98677.doc 235

60 120 180 240 300 360 420 480 540 600 607 200533758 <212〉 DNA <213〉人類 <220> <223> Probe 1024_at HG-U95Av2 <400〉 9 aagctctgaa gaactctctg gaagcccctg ggcccagtac ctagctggct ctgtgagggt gctgactggc ttcagcaagt tagaactagc caaaccagga ccctgtcca60 120 180 240 300 360 420 480 540 600 607 200533758 < 212〉 DNA < 213〉 Human < 220 > < 223 > Probe 1024_at HG-U95Av2 < 400> 9 aagctctgaga gaactctctg gaagcccctg ggcccagtac ctagctggctcta ctgctcctgga ctgg ccctgtcca

60 109 <210> 10 <211〉 439 <212> DNA <213>人類 <220〉 <223> Probe 1052—s_at HG-U95Av260 109 < 210 > 10 < 211> 439 < 212 > DNA < 213 > human < 220> < 223 > Probe 1052—s_at HG-U95Av2

<400〉 10 agaacgagaa agttcttcaa ggtaacgcgc ccggagcgga acatagacca cgtgtttatt ttgatgcagc ttgtattgta gctgcaccag gcagctgccc ggccggggcg cgccctgctg aagaagctac ttcccttaaa taaggtacat gataagagg cgcgtggagc agcccgccct ggagagactc ccgacgccag agcctggact ttatttttgt ttgtaaaaag agctcacgcg tcctgccggc agcaacgacc agccgccgcg taccaccact aatggtagct aaaaaaaacc ggacctggcc cgccgggaca catacctcag tgcccgctgc aaactgcgag ttttctacat agacttttca ggcctccggc gcagactgcc acccgacggc agtttcttgg agaagctaaa cttactcctg gacaaaccct 60 120 180 240 300 360 420 439 98677.doc≪ 400> 10 agaacgagaa agttcttcaa ggtaacgcgc ccggagcgga acatagacca cgtgtttatt ttgatgcagc ttgtattgta gctgcaccag gcagctgccc ggccggggcg cgccctgctg aagaagctac ttcccttaaa taaggtacat gataagagg cgcgtggagc agcccgccct ggagagactc ccgacgccag agcctggact ttatttttgt ttgtaaaaag agctcacgcg tcctgccggc agcaacgacc agccgccgcg taccaccact aatggtagct aaaaaaaacc ggacctggcc cgccgggaca catacctcag tgcccgctgc aaactgcgag ttttctacat agacttttca ggcctccggc gcagactgcc acccgacggc agtttcttgg agaagctaaa cttactcctg gacaaaccct 60 120 180 240 300 360 420 439 98677.doc

200533758 <210〉 11 <211〉 463 <212〉 DNA <213>人類 <220〉 <223> Probe 1058—at HG-U95Av2 <400〉 11 ctaagctttt ctctcatagc gtagacctag ggaagggatg ggaagattgc ccagtccccg aiggctgcgc acacaggagg cggcggacga caaggcaagt gagtttgcac tgtcagcccc agaccgtaag cttggctaca ctgatgtttt tctttactaa ggatactatt caaaaattaa cattttcatc tcagtaagtt tttagaacat caaaatgttt tctgagctcc aagtggctag gttgtaaaag ttttataata atttgcaatt aaaatacatg atacatatta atccattaaa gactagtggg aatgtatcag ccagagtagc aagtaatttt tgttttataa atcatagtat ctgtcatctt gcagtattac caatgctgtt gtaaattgaa tttaaagtgg tattaaaaaa aactgttaaa caatttttat ctgtttgtat atcttactat aga <210> 12 <211> 295 <212> DNA <213>人類 <220> <223〉 Probe 1061—at HG-U95Av2 <400> 12 tcatgccaag acagtatcag acacagcccc agaagggggc attatgggcc ctgcctcccc ataggccatt tggactctgc cttcaaacaa aggcagttca gtccacaggc atggaagctg 986,7.doc 60 120 180 240 300 360 420 463 60 120 200533758 tgaggggaca ggcctgtgcg tgccatccag agtcatctca gccctgcctt tctctggagc attctgaaaa cagatattct ggcccaggga atccagccat gacccccacc cctctgccaa agtactctta ggtgccagtc tggtaactga actccctctg gaggcaggct tgagg <210> 13 <211〉 313 <212〉 DNA <213>人類200533758 < 210〉 11 < 211〉 463 < 212〉 DNA < 213 > Human < 220〉 < 223 > Probe 1058-at HG-U95Av2 < 400> 11 ctaagctttt ctctcatagc gtagacctag ggaagggatg ggaagattgc ccagtcggaggg agg caaggcaagt gagtttgcac tgtcagcccc agaccgtaag cttggctaca ctgatgtttt tctttactaa ggatactatt caaaaattaa cattttcatc tcagtaagtt tttagaacat caaaatgttt tctgagctcc aagtggctag gttgtaaaag ttttataata atttgcaatt aaaatacatg atacatatta atccattaaa gactagtggg aatgtatcag ccagagtagc aagtaatttt tgttttataa atcatagtat ctgtcatctt gcagtattac caatgctgtt gtaaattgaa tttaaagtgg tattaaaaaa aactgttaaa caatttttat ctgtttgtat atcttactat aga < 210 > 12 < 211 > 295 < 212 > DNA < 213 > Humans < 220 > < 223> Probe 1061-at HG-U95Av2 < 400 > 12 tcatgccaag acagtatcag acacagcccc agaagggggc attatgggcc 240ca, cccacgtaccacgtcca ccgcc ccgcctcagcca ccgcctca 360 420 463 60 120 200533758 tgaggggaca ggcctgtgcg tgccatccag agt catctca gccctgcctt tctctggagc attctgaaaa cagatattct ggcccaggga atccagccat gacccccacc cctctgccaa agtactctta ggtgccagtc tggtaactga actccctctg gaggcaggct tgagg < 210 > 13 < 211> DNA 313 < 213

<220〉 <223〉 Probe 1069一at HG-U95Av2< 220〉 < 223〉 Probe 1069-at HG-U95Av2

<400〉 13 ggttgaatgt tagcctgaat cgttaatttg taatattttt aattttcttt atcttcttta ttgtccttag gtgccataag ttcagccaca aaatcaaacg tgggaagagg caa gataggccta actgaccttt atttattgag ctgattacag gagaaaatga tgtgctagcc taaaatgttt aaaatattct ataatagtat aataaatatc cacaaagaat tgagggatct gtgtcaagca ttatataaat attaaagata attgtctcat gtggatgctt ctgtgggttt aattgaaaaa actcaggaga <210〉 14 <211> 529 <212〉 DNA <213>人類 <220> <223〉 Probe 1086—at HG-U95Av2 98677.doc 60 60≪ 400> 13 ggttgaatgt tagcctgaat cgttaatttg taatattttt aattttcttt atcttcttta ttgtccttag gtgccataag ttcagccaca aaatcaaacg tgggaagagg caa gataggccta actgaccttt atttattgag ctgattacag gagaaaatga tgtgctagcc taaaatgttt aaaatattct ataatagtat aataaatatc cacaaagaat tgagggatct gtgtcaagca ttatataaat attaaagata attgtctcat gtggatgctt ctgtgggttt aattgaaaaa actcaggaga < 210> 14 < 211 > 529 < 212 〉 DNA < 213 > Human < 220 > < 223> Probe 1086-at HG-U95Av2 98677.doc 60 60

200533758 <400〉 14 agatgtgtcc ccaacatccc cacagcccga gggcctcctt gtcctgcagc aagtgggcga ctattgcttc ctccccggcc tggggcccgg ccctctctcg ctccggagta aaccttcttc cccgggaccc ggtcctgaga tcaagaacct agaccaggct tttcaagtca agaagccccc aggccaggct gtgccccagg tgcccgtcat tcagctcttc aaagccctga agcagcagga ctacctgtct ctgccccctt gggaggtcaa caagcctggg gaggtgtgtt gagaccccca ggcctagaca ggcaagggga tggagagggc ttgccttccc tcccgcctga ccttcctcag tcatttctgc aaagccaagg ggcagcctcc tgtcaaggta gctagaggcc tgggaaagga gatagccttg ctccggcccc cttgaccttc agcaaatcac ttctctccct gcgctcacac agacacacac acacacacgt acatgcacac atttttcctg tcaggttaa <210〉 15 <211〉 369 <212〉 DNA <213>人類 <220〉 <223> Probe 1102_s_at HG-U95Av2 <400〉 15 gtgaaggttg ctgaggctct gacccagtga gattacagag gaagttatcc tctgcctccc attctgacca cccttctcat tccaacagtg agtctgtcag cgcaggttta gtttactcaa tctccccttg cactaaagta tgtaaagtat gtaaacagga gacaggaagg tggtgcttac atccttaaag gcaccatcta atagcgggtt actttcacat acagccctcc cccagcagtt gaatgacaac agaagcttca gaagtttggc aatagtttgc atagaggtac cagcaatatg 120 180 240 300 360 420 480 529 60 120 180 240 98677.doc -10- 300 360200533758 taaatagtgc agaatctcat aggttgccaa taatacacta attcctttct atcctacaac aagagttta 369 <210〉 16 <211> 132 <212> DNA <213>人類200533758 < 400> 14 agatgtgtcc ccaacatccc cacagcccga gggcctcctt gtcctgcagc aagtgggcga ctattgcttc ctccccggcc tggggcccgg ccctctctcg ctccggagta aaccttcttc cccgggaccc ggtcctgaga tcaagaacct agaccaggct tttcaagtca agaagccccc aggccaggct gtgccccagg tgcccgtcat tcagctcttc aaagccctga agcagcagga ctacctgtct ctgccccctt gggaggtcaa caagcctggg gaggtgtgtt gagaccccca ggcctagaca ggcaagggga tggagagggc ttgccttccc tcccgcctga ccttcctcag tcatttctgc aaagccaagg ggcagcctcc tgtcaaggta gctagaggcc tgggaaagga gatagccttg ctccggcccc cttgaccttc agcaaatcac ttctctccct gcgctcacac agacacacac acacacacgt acatgcacac atttttcctg tcaggttaa < 210〉 15 < 211〉 369 < 212〉 DNA < 213 > gt2 Probe102 1 gattacagag gaagttatcc tctgcctccc attctgacca cccttctcat tccaacagtg agtctgtcag cgcaggttta gtttactcaa tctccccttg cactaaagta tgtaaagtat gtaaacagga gacaggaagg tggtgcttac atccttaaag gcaccat gcaccat acaac agaagcttca gaagtttggc aatagtttgc atagaggtac cagcaatatg 120 180 240 300 360 420 480 529 60 120 180 240 98677.doc -10- 300 360200533758 taaatagtgc agaatctcat aggttgccaa &ta; 210 <211; 213 > Human

<220> <223> Probe 1105_s.at HG-U95Av2 <400〉 16 ctagctccaa aaccatccca ggtcattctt catcctcacc caggattctc ctgtacctgc tcccaatctg tgttcctaaa agtgattctc actctgcttc tcatctccta cttacatgaa tacttctctc tt 60 120 132 <210〉 17 <211〉 451 <212> DNA φ <213>人類 <220> <223> Probe 1113_at HG-U95Av2 <400〉 17 aagatgaaca cagctggtca cagataaggc cattgctagt aacttttggc catgatggaa aagggcatcc tctccacaaa agagaaaaac gtcaagccaa acacaaacag cggaaacgcc ttaagtccag ctgtaagaga caccctttgt acgtggactt cagtgacgtg gggtggaatg actggattgt ggctcccccg gggtatcacg ccttttactg ccacggagaa tgcccttttc 60 120 180 98677.doc -11- 240 200533758 ctctggctga ttaactctaa tgtaccttga gttgtgggtg tcatctgaac gattcctaag cgagaatgaa tcgctagtac tccactaatc gcatgctgtg aaggttgtat agcaaaatta atgccattgt tcccgacaga taaagaacta a tcagacgttg actcagtgct tcaggacatg gtcaactctg atctcgatgc gttgtggagg 300 360 420 451< 220 &> ; DNA φ < 213 > human < 220 > < 223 > Probe 1113_at HG-U95Av2 < 400> 17 aagatgaaca cagctggtca cagataaggc cattgctagt aacttttggc catgatggaa aagggcatcc tctccacaaa agagaaaaac gtcaagccaa acacaaacag cggaaacgcc ttaagtccag ctgtaagaga caccctttgt acgtggactt cagtgacgtg gggtggaatg actggattgt ggctcccccg gggtatcacg ccttttactg ccacggagaa tgcccttttc 60 120 180 98677.doc -11- 240 200533758 ctctggctga ttaactctaa tgtaccttga gttgtgggtg tcatctgaac gattcctaag cgagaatgaa tcgctagtac tccactaatc gcatgctgtg aaggttgagcgagcat gcat gagat gagatcat

<210> 18 <211> 505 <212〉 DNA <213>人類 <220〉 <223> Probe lll〇t HG-U95Av2 <400〉 18 caggattagc cgatcgttac ctcaagggag tgggaattgg gcccagctcc ggcccctcct ggtcaccttt ggccatgatg gccggggcca tgccttgacc cgacgccgga gggccaagcg tagccctaag catcactcac agcgggccag gaagaagaat aagaactgcc ggcgccactc gctctatgtg gacttcagcg atgtgggctg gaatgactgg attgtggccc caccaggcta ccaggccttc tactgccatg gggactgccc ctttccactg gctgaccacc tcaactcaac caaccatgcc attgtgcaga ccctggtcaa ttctgtcaat tccagtatcc ccaaagcctg ttgtgtgccc actgaactga gtgccatctc catgctgtac ctggatgagt atgataaggt ggtactgaaa aattatcagg agatggtagt agagggatgt gggtgccgct gagatcaggc agtccttgag gatagacaga tatac 60 120 180 240 300 360 420 480 98677.doc -12 - 505 200533758 <210〉 19 <211> 168 <212> DNA <213>人類 <220> <223〉 Probe 1126一s—at HG-U95Av2 <400〉 19 aaagctagtg atcaacagtg gcaatggagc tgtggaggac agaaagccaa gtggactcaa cggagaggcc agcaagtctc aggaaatggt gcatttggtg aacaaggagt cgtcagaaac< 210 > 18 < 211 > 505 < 212> DNA < 213 > Human < 220> < 223 > Probe lll〇t HG-U95Av2 < 400> 18 caggattagc cgatcgttac ctcaagggag tgggaattgg gcccagctcc ggcgcctcctcctcct cgacgccgga gggccaagcg tagccctaag catcactcac agcgggccag gaagaagaat aagaactgcc ggcgccactc gctctatgtg gacttcagcg atgtgggctg gaatgactgg attgtggccc caccaggcta ccaggccttc tactgccatg gggactgccc ctttccactg gctgaccacc tcaactcaac caaccatgcc attgtgcaga ccctggtcaa ttctgtcaat tccagtatcc ccaaagcctg ttgtgtgccc actgaactga gtgccatctc catgctgtac ctggatgagt atgataaggt ggtactgaaa aattatcagg agatggtagt agagggatgt gggtgccgct gagatcaggc agtccttgag gatagacaga tatac 60 120 180 240 300 360 420 480 98677 .doc -12-505 200533758 < 210〉 19 < 211 > 168 < 212 > DNA < 213 > human < 220 > < 223〉 Probe 1126-s-at HG-U95Av2 < 400〉 19 aaagctagtg atcaacagtg gcaatggagc tgtggaggac agaaagccaa gtggactcaa cggagaggcc agcaagtctc aggaaatggt gcatttggtg aacaaggagt cgtcag aaac

tccagaccag tttatgacag ctgatgagac aaggaacctg cagaatgt <210〉 20 <211〉 547 <212> DNA <213>人類 <220〉 <223> Probe 1184一at HG-U95Av2 <400〉 20 tcagctcttg caagaggact ccctcaatgt ggctgacttg acttccctcc gggccccact ggacatcccc atcccagacc ctccacccaa ggatgatgag atggaaacag ataagcagga gaagaaagaa gtccctaagt gtggatttct ccctgggaat gagaaagtcc tgtccctgct tgccctggtt aagccagaag tctggactct caaagagaaa tgcattctgg tgattacatg gatccaacac ctgatcccca agattgaaga tggaaatgat tttggggtag caatccagga gaaggtgctg gagagggtga atgccgtcaa gaccaaagtg gaagctttcc agacaaccat ttccaagtac ttctcagaac gtggggatgc tgtggccaag gcctccaagg agactcatgt 98677.doc -13- 200533758 aatggattac cgggccttgg tgcatgagcg agatgaggca gcctatgggg agctcagggc catggtgctg gacctgaggg ccttctatgc tgagctttat catatcatca gcagcaacct ggagaaa <210〉 21 <211> 397 <212〉 DNA <213> 人類tccagaccag tttatgacag ctgatgagac aaggaacctg cagaatgt < 210〉 20 < 211> 547 < 212 > DNA < 213 > human < 220〉 < 223 > Probe 1184-at HG-U95Av2 < 400> 20 tcagctctctctctggcag gggccccact ggacatcccc atcccagacc ctccacccaa ggatgatgag atggaaacag ataagcagga gaagaaagaa gtccctaagt gtggatttct ccctgggaat gagaaagtcc tgtccctgct tgccctggtt aagccagaag tctggactct caaagagaaa tgcattctgg tgattacatg gatccaacac ctgatcccca agattgaaga tggaaatgat tttggggtag caatccagga gaaggtgctg gagagggtga atgccgtcaa gaccaaagtg gaagctttcc agacaaccat ttccaagtac ttctcagaac gtggggatgc tgtggccaag gcctccaagg agactcatgt 98677.doc -13- 200533758 aatggattac cgggccttgg tgcatgagcg agatgaggca gcctatgggg agctcagggc catggtgctg gacctgaggg ccttctatgc tgagctttat catatcatca gcagcaacct ggagaaa < 210〉 21 < 211 > 397 < 212〉 DNA < 213 > human

<220> <223〉 Probe 1207—at HG-U95Av2 <400〉 21 ttctccgagg tctggacttt cttcattcac accgagtagt gcatcgcgat ctaaaaccac agaacattct ggtgaccagc agcggacaaa taaaactcgc tgacttcggc cttgcccgca tctatagttt ccagatggct ctaacctcag tggtcgtcac gctgtggtac agagcacccg aagtcttgct ccagtccagc tacgccaccc ccgtggatct ctggagtgtt ggctgcatat ttgcagaaat gtttcgtaga aagcctcttt ttcgtggaag ttcagatgtt gatcaactag gaaaaatctt ggacgtgatt ggactcccag gagaagaaga ctggcctaga gatgttgccc ttcccaggca ggcttttcat tcaaaatctg cccaacc <210> 22 <211> 481 <212> DNA <213> 人類 <220> 98677.doc -14- 200533758 <223> Probe 120_at HG-U95Av2 <400〉 22 tgacatcaaa actgcagacc catcaactga ccatcacatg tggttaccct ccatatcttt ccatctcaaa taatctcact gtgctgtacc gaggatcctt cgaggcacaa tcttctgaca caactggatt tcagtatcaa ttctggactg tcagccaagt gtcatcttct ctctggaaag caatacatgt caatgtttcg gagaatgcaa aaaatgacta aaatttgcta cttatcttgt ggaaaccaac ttttataaaa tcatattttt ccagcltaaa tcttactata aggggagaac ttcggagtga ttcaaatatc cttttgccgg aaatgcatct caaagatggg attgttgctg ctggttttaa ctaccgggca ttaatgctgc gtagcagcaa gagtgccatt teattttagc tcaaaaaaga atgggtcatc actgtggaag gagettgeta ctgctgagtg attggattet <210> 23 <211〉 595 <212〉 DNA φ <213〉人類 <220> <223> Probe 1212—at HG-U95Av2 <400〉 23 gccctggagc atggctgatc accccctacc gtgtctcacc agatcctaca tgtgcttggt ctaccatcag cctgccggca gagcacagcg gcctcaggtg ctccatcaac gccagataca ggcatatact gcaaatgctg aagaggctgc cccactgagc gtgtaggaga aaagattcaa tggtcttgga tgagggccta cgaggtgacc ggtggatctc ggccttccag gctcccaaat 98677.doc -15 - 200533758 cctgccccgt tggcacaggg ccacaggagc agaagctggg tgggctgaag aggcctggaa 300 acgagagtct taattgagga gatgggagac tcgaactcta gccctggatc tgccttcctg 360 ctgaaacttg ttccacctca gtcccctcat ctgtcacacg catgtggggt ggagtaggga 420 gatgcgggga gcagggtggg caggaatact gttatctatg tgacggggca gtcgtgaggc 480 tgagatgaga atgcggatta aaatgcctgg cgtgctcacc gtaacaccac ggggaaggct 540 gtgtgccttt tctcatccgc ttttgttgtg tgtgactcca aagaatgccc gcgct 595≪ 220 > < 223> Probe 1207-at HG-U95Av2 < 400> 21 ttctccgagg tctggacttt cttcattcac accgagtagt gcatcgcgat ctaaaaccac agaacattct ggtgaccagc agcggacaaa taaaactcgc tgacttcggc cttgcccgca tctatagttt ccagatggct ctaacctcag tggtcgtcac gctgtggtac agagcacccg aagtcttgct ccagtccagc tacgccaccc ccgtggatct ctggagtgtt ggctgcatat ttgcagaaat gtttcgtaga aagcctcttt ttcgtggaag ttcagatgtt gatcaactag gaaaaatctt ggacgtgatt ggactcccag gagaagaaga ctggcctaga gatgttgccc ttcccaggca ggcttttcat tcaaaatctg cccaacc < 210 > 22 < 211 > 481 < 212 > DNA < 213 > human 98-223-lt > 220 > 220 > 220 > 220 < 400> 22 tgacatcaaa actgcagacc catcaactga ccatcacatg tggttaccct ccatatcttt ccatctcaaa taatctcact gtgctgtacc gaggatcctt cgaggcacaa tcttctgaca caactggatt tcagtatcaa ttctggactg tcagccaagt gtcatcttct ctctggaaag caatacatgt caatgtttcg gagaatgcaa aaaatgacta aaatttgcta cttatcttgt ggaaaccaac ttttataaaa tcatattttt ccagcltaaa tcttactata aggggagaac ttcggagtga ttcaaat atc cttttgccgg aaatgcatct caaagatggg attgttgggg ctggttttaa ctaccgggca ttaatgctgc gtagcagcaa gagtgccatt teattttagc tcaaaaaaga atgggtcatc actgt &212; < 212 < 212 < 212 < 212 < < 212 < 212 HG-U95Av2 < 400> 23 gccctggagc atggctgatc accccctacc gtgtctcacc agatcctaca tgtgcttggt ctaccatcag cctgccggca gagcacagcg gcctcaggtg ctccatcaac gccagataca ggcatatact gcaaatgctg aagaggctgc cccactgagc gtgtaggaga aaagattcaa tggtcttgga tgagggccta cgaggtgacc ggtggatctc ggccttccag gctcccaaat 98677.doc -15 - 200533758 cctgccccgt tggcacaggg ccacaggagc agaagctggg tgggctgaag aggcctggaa 300 acgagagtct taattgagga gatgggagac tcgaactcta gccctggatc tgccttcctg 360 ctgaaacttg ttccacctca gtcccctcat ctgtcacacg catgtggggt ggagtaggga 420 gatgcgggga gcagggtggg caggaatact gttatctatg tgacggggca gtcgtgaggc 480 tgagatgaga atgcggatta aaatgcctgg cgtgctcacc gtaacaccac ggggaaggct 540 gtgtgccttt tctcatccgc ttttgttgtg tgtgactcca aagaatg ccc gcgct 595

<210〉 24 <211> 301 <212> DNA <213> 人類 <220〉 <223> Probe 1223一at HG-U95Av2 <400> 24< 210> 24 < 211 > 301 < 212 > DNA < 213 > human < 220> < 223 > Probe 1223-at HG-U95Av2 < 400 > 24

gcgtgaccgc cttctctgag ttccgcacct acagcttccc ctgctacctc ccgcagccgc 60 tcatcaacca cgcgcccagg ttggatacgg atggcatcca cctcctgagc agcctgctcg 120 tgtatgaatc caagagtcgc atgtcagcag aggctgccct gagtcactcc tacttccggt 180 ctctgggaga gcgtgtgcac cagcttgaag acactgcctc catcttctcc ctgaaggaga 240 tccagctcca gaaggaccca ggctaccgag gcttggcctt ccagcagcca ggacgaggga 300 a 301 <210〉 25 <211> 85 98677.doc 16- 200533758 <212〉 DNA <213> 人類 <220〉 <223> Probe 1226—at HG-U95Av2 <400> 25 ttatattgat aacagcactg actagggaaa tgatcagttt tttttttata cactgtaatg 60 aaccgctgaa tatgaggcat ttggc 85gcgtgaccgc cttctctgag ttccgcacct acagcttccc ctgctacctc ccgcagccgc 60 tcatcaacca cgcgcccagg ttggatacgg atggcatcca cctcctgagc agcctgctcg 120 tgtatgaatc caagagtcgc atgtcagcag aggctgccct gagtcactcc tacttccggt 180 ctctgggaga gcgtgtgcac cagcttgaag acactgcctc catcttctcc ctgaaggaga 240 tccagctcca gaaggaccca ggctaccgag gcttggcctt ccagcagcca ggacgaggga 300 a 301 < 210> 25 < 211 > 85 98677.doc 16- 200533758 < 212〉 DNA < 213 > Humans < 220> < 223 > Probe 1226-at HG-U95Av2 < 400 > 25 ttatattgat aacagcactg actagggaaa tgatcagttt tttttttattata cactgtaatg 60 aaccgctgaa tatga

<210> 26 <211> 337 <212〉 DNA <213> 人類 <220〉 <223> Probe 1227一g一at HG-U95Av2 <400〉 26 60 120 180 240 300 337 aactggacca ccagagaatg gacaccatcc aggaagaccc cagcacagac tcacatatgg acgaggatgg gtttgagaag gaccccttcc caaatagcag cacagctgcc aagtcatttg aggatctcac ggaccatccg gtcaccagaa gtgaaaaggc tgcctccttt aaactgcagc gtcagaatcg tgttgacagc aaagaaacag agtgctaatt tagttctcag ctcttctgac ttaagtgtgc aaaatatttt tatagatttg acctacaatc aatcacagct tatattttgt gaagactggg aagtgactta gcagatgctg gtcatgt <210> 27 <211> 547 <212> DNA <213> 人類 9S677.doc -17- 200533758 <220〉 <223> Probe 1237_at HG-U95Av2 tccccctgct gtaaatgcag gtctcttggt atttattgag ctitgtggga ctggtggaag <400〉 27 agaccgaggc gcgtcgttaa tcctaggtga caggacacct gacgtcccgg tccagcattc gatccgtgag ttgggggttg acaaata gcatagagac tttatttctt tgagatgtgt ggaactgcgg ctgggatgaa tcaactccgt atccttccat gtgggctgtc cgagcacagc attgctccta acgtaatatt caaagtagga gtctggtggt ctgtctactg cttcttgaag acggagcgac ccagctgggc attaatattt tattttaact gaagaaatgg gggtcgtaag tgtgagactt tcgcctttag tgtcgagatc taggcccggt atatgtattt tatgcaaggg ggaggactcg tttaggaggt cggcggacca ggtggctgcg gcctagtatg gggaaggaga atgtacgtcc tgtgagatgt ggtgggggag gactgcatcc ttaggaatga aggtagaggg ttctgtgaac 60 120 180 240 300 360 420 480 540 547< 210 > 26 < 211 > 337 < 212> DNA < 213 > Human < 220> < 223 > Probe 1227-g-at HG-U95Av2 < 400> 26 60 120 180 240 300 337 aactggacca ccagagaatg gacaccatcc aggaagaccc cagcacagac tcacatatgg acgaggatgg gtttgagaag gaccccttcc caaatagcag cacagctgcc aagtcatttg aggatctcac ggaccatccg gtcaccagaa gtgaaaaggc tgcctccttt aaactgcagc gtcagaatcg tgttgacagc aaagaaacag agtgctaatt tagttctcag ctcttctgac ttaagtgtgc aaaatatttt tatagatttg acctacaatc aatcacagct tatattttgt gaagactggg aagtgactta gcagatgctg gtcatgt < 210 > 27 < 211 > 547 < 212 > DNA < 213 > human 9S677.doc -17- 200533758 < 220> < 223 > Probe 1237_at HG-U95Av2 tccccctgct gtaaatgcag gtctcttggt atttattgag ctitgtggga ctggtggaag < 400> 27 agaccgaggc gcgtcgttaa tcctaggtga caggacacct gacgtcccgg tccagcattc gatccgtgag ttgggggttg acaaata gcatagagac tttatttctt tgagatgtgt ggaactgcgg ctgggatgaa tcaactccgt atccttccat gtgggctgtc cgagcacagc attgctccta acgtaatatt caaagtagga gtctggtggt ctgtctactg cttctt gaag acggagcgac ccagctgggc attaatattt tattttaact gaagaaatgg gggtcgtaag tgtgagactt tcgcctttag tgtcgagatc taggcccggt atatgtattt tatgcaaggg ggaggactcg tttaggaggt cggcggacca ggtggctgcg gcctagtatg gggaaggaga atgtacgtcc tgtgagatgt ggtgggggag gactgcatcc ttaggaatga aggtagaggg ttctgtgaac 60 120 180 240 300 360 420 480 540 547

<210> 28 <211〉 373 <212〉 DNA <213> 人類 <220〉 <223〉 Probe 128一at HG-U95Av2 <400> 28 60 cctacccata tgtgggacag gaagagagtt gtatgtacaa cccaacaggc aaggcagcta aatgcagagg gtacagagag atccccgagg ggaatgagaa agccctgaag agggcagtgg 98677.doc -18- 120 200533758 cccgagtggg acctgtctct gcaaaggtgt gtattatgat cagtgggata tggaatccag aaaactgggg aaacaaagga ttgccaacct ggc gtggccattg atgcaagcct gacctccttc cagttttaca gaaagctgca atagcgataa tctgaaccat gcggttttgg aagggaaaca agcactggat aattaaaaac agctggggag tatatcctca tggctcgaaa taagaacaac gcctgtggca< 210 > 28 < 211〉 373 < 212〉 DNA < 213 > Humans < 220〉 < 223〉 Probe 128 a at HG-U95Av2 < 400 > 28 60 cctacccata tgtgggacag gaagagagtt gtatgtacaa cccaacaggc aaggcagaga aacggat ggaatgagaa agccctgaag agggcagtgg 98677.doc -18- 120 200533758 cccgagtggg acctgtctct gcaaaggtgt gtattatgat cagtgggata tggaatccag aaaactgggg aaacaaagga ttgccaacct ggc gtggccattg atgcaagcct gacctccttc cagttttaca gaaagctgca atagcgataa tctgaaccat gcggttttgg aagggaaaca agcactggat aattaaaaac agctggggag tatatcctca tggctcgaaa taagaacaac gcctgtggca

<210〉 29 <211> 228 <212〉 DNA <213>人類 <220> <223> Probe 129—g—at HG-U95Av2< 210> 29 < 211 > 228 < 212> DNA < 213 > human < 220 > < 223 > Probe 129-g-at HG-U95Av2

<400〉 29 agactctgtc tggttcctgt tggcaaactc ctgtggaggg gactatcgaa tgggctttta ttaaatctga ggctacatga agaaaggata gctctgtggg gtccccagaa ccaatgcctt tgttactcct tgccctggag cctagtggat ccaatatgtg gtcaaaaatc ggccaactca tgtgtgtctg cagaagaa agggtcagtg agaagaaaac agaatgatgg <210> 30 <211> 560 <212〉 DNA <213>人類 <220> <223〉 Probe 1334—s—at HG-U95Av2 98677.doc -19- 60 60≪ 400> 29 agactctgtc tggttcctgt tggcaaactc ctgtggaggg gactatcgaa tgggctttta ttaaatctga ggctacatga agaaaggata gctctgtggg gtccccagaa ccaatgcctt tgttactcct tgccctggag cctagtggat ccaatatgtg gtcaaaaatc ggccaactca tgtgtgtctg cagaagaa agggtcagtg agaagaaaac agaatgatgg < 210 > 30 < 211 > 560 < 212> DNA < 213 > human < 220 > < 223> Probe 1334—s—at HG-U95Av2 98677.doc -19- 60 60

200533758 <400〉 30 atttattact atgactgctc cccagccctg gctctgcaat gggcactggg atgagccgct gtgagcccct ggtcctgagg gtccccacct gggacccttg agagtatcag gtctcccacg tgggagacaa gaaatccctg tttaatattt aaacagcagt gttccccatc tgggtccttg cacccctcac tctggcctca gccgactgca cagcggcccc tgcatcccct tggctgtgag gcccctggac aagcagaggt ggccagagct gggaggcatg gccctggggt cccacgaatt tgctggggaa tctcgttttt cttcttaaga cttttgggac atggtttgac tcccgaacat caccgacgtg tctcctgttt ttctgggtgg cctcgggaca cctgccctgc ccccacgagg gtcaggactg tgactctttt tagggccagg caggtgcctg gacatttgcc ttgctggatg gggactgggg atgtgggagg gagcagacag gaggaatcat gtcaggcctg tgtgtgaaag gaagctccac tgtcaccctc <210〉 31 <211> 361 <212〉 DNA <213> 人類 <220〉 <223〉 Probe 1369一s一at HG-U95Av2 120 180 240 300 360 420 480 540 560 <400> 31 ttttcctaga aatatccgaa tcacataaaa ggattttttt tattgcacgg ctttaatttc atgatgggac ctgttaaatc gagaatatac aggaattgaa aataaatttt tggcaaccct aaatagcaaa tgggtttgct gccataaagt agtctgctag attgggccaa agaatgtgat caaatttagc ccaggatcca gggccaagag atttgaagca tggaaatcct caagtccttg 60 120 180 240 98677.doc -20- 200533758 ttccactgtg ccttggtttc tcctttattt ctaagtggaa aaagtattag ccaccatctt 300 acctcacagt gatgttgtga ggacatgtgg aagcacttta agttttttca tcataacata 360 361 <210〉 32 <211> 553 <212〉 DNA <213> 人類 <220〉 <223> Probe 1370 at HG-U95Av2 <400> 32 cccatctgag gatgtagtcg tcactccaga aagctttgga agagattcat ccctcacatg 60 cctggctggg aatgtcagtg catgtgacgc ccctattctc tcctcttcca ggtccctaga 120 ctgcagggag agtggcaaga atgggcctca tgtgtaccag gacctcctgc ttagccttgg 180 gactacaaac agcacgctgc cccctccatt ttctctccaa tctggaatcc tgacattgaa 240 cccagttgct cagggtcagc ccattcttac ttccctggga tcaaatcaag aagaagcata 300 tgtcaccatg tccagcttct accaaaacca gtgaagtgta agaaacccag actgaactta 360 ccgtgagcga caaagatgat ttaaaaggga agtctagagt tcctagtctc cctcacagca 420 cagagaagac aaaattagca aaaccccact acacagtctg caagattctg aaacattgct 480 ttgaccactc ttcctgagtt cagtggcact caacatgagt caagagcatc ctgcttctac 540 553 catgtggatt tgg 9S677.doc -21 _200533758 < 400> 30 atttattact atgactgctc cccagccctg gctctgcaat gggcactggg atgagccgct gtgagcccct ggtcctgagg gtccccacct gggacccttg agagtatcag gtctcccacg tgggagacaa gaaatccctg tttaatattt aaacagcagt gttccccatc tgggtccttg cacccctcac tctggcctca gccgactgca cagcggcccc tgcatcccct tggctgtgag gcccctggac aagcagaggt ggccagagct gggaggcatg gccctggggt cccacgaatt tgctggggaa tctcgttttt cttcttaaga cttttgggac atggtttgac tcccgaacat caccgacgtg tctcctgttt ttctgggtgg cctcgggaca cctgccctgc ccccacgagg gtcaggactg tgactctttt tagggccagg caggtgcctg gacatttgcc ttgctggatg gggactgggg atgtgggagg gagcagacag gaggaatcat gtcaggcctg tgtgtgaaag gaagctccac tgtcaccctc < 210〉 31 < 211 > 361 < 212> one < 213 < 213 < 213 < 213 < 213 < 213 < 213 < 213 < 213 < 213 > 180 240 300 360 420 480 540 560 < 400 > 31 ttttcctaga aatatccgaa tcacataaaa ggattttttttt tattgcacgg ctttaatttc atgatgggac ctgttaaatc gagaatatac aggaattgaa aggaagt aggatgat gcc tgat caaatttagc ccaggatcca gggccaagag atttgaagca tggaaatcct caagtccttg 60 120 180 240 98677.doc -20- 200533758 ttccactgtg ccttggtttc tcctttattt ctaagtgglt; > 360> agtgt agtgttgtttgtt 213 > human < 220> < 223 > Probe 1370 at HG-U95Av2 < 400 > 32 cccatctgag gatgtagtcg tcactccaga aagctttgga agagattcat ccctcacatg 60 cctggctggg aatgtcagtg catgtgacgc ccctattctc tcctcttcca ggtccctaga 120 ctgcagggag agtggcaaga atgggcctca tgtgtaccag gacctcctgc ttagccttgg 180 gactacaaac agcacgctgc cccctccatt ttctctccaa tctggaatcc tgacattgaa 240 cccagttgct cagggtcagc ccattcttac ttccctggga tcaaatcaag aagaagcata 300 tgtcaccatg tccagcttct accaaaacca gtgaagtgta agaaacccag actgaactta 360 ccgtgagcga caaagatgat ttaaaaggga agtctagagt tcctagtctc cctcacagca 420 cagagaagac aaaattagca aaaccccact acacagtctg caagattctg aaacattgct 480 ttgaccactc ttcctgagtt cagtggcact caacatgagt caagagcatc ctgct tctac 540 553 catgtggatt tgg 9S677.doc -21 _

200533758 <210〉 33 <211〉 433 <212〉 DNA <213>人類 <220〉 <223〉 Probe 1372—at HG-U95Av2 <400〉 33 atcttttgga actcctttga tctcactgtt attattaaca tttatttatt atttttctaa atgtgaaaga aatacataat ttagggaaaa ttggaaaata taggaaactt taaacgagaa aatgaaacct ctcataatcc cactgcatag aaataacaag cgttaacatt ttcatatttt tttctttcag tcatttttgt atttgtggta tatgtatata tgtacctata tgtatttgca tttgaaattt tggaatcctg ctctatgtac agttttgtat tatacttttt aaatcttgaa ctttatgaac attttctgaa atcattgatt attctacaaa aacatgattt taaacagctg taaaatattc tatgatatga atgttttatg cattatttaa gcctgtctct attgttggaa tttcaggtca ttt <210〉 34 <211> 247 <212〉 DNA <213> 人類 <220> <223〉 Probe 1377_at HG-U95Av2 <400〉 34 gtccacaaga cagaagctga agtgcatcca aaggtgctca gagagccggc ccgcctgaat cattctcgat ttaactcgag accttttcaa cttggcttcc tttcttggtt cataaatgaa 60 120 180 240 300 360 420 433 60 98677.doc .22 - 120 200533758 ttttagtttg gttcacttac agatagtatc tagcaatcac aacactggct gagcggatgc atctggggat gaggttgctt actaagcttt gccagctgct gctggatcac agctgctttc tgttgtc <210> 35 <211> 244 <212〉 DNA <213〉人類200533758 < 210〉 33 < 211〉 433 < 212〉 DNA < 213 > Human < 220〉 < 223〉 Probe 1372-at HG-U95Av2 < 400〉 33 atcttttgga actcctttga tctcactgtt attattaaca tttatttatt atttttctaaatatgaaaga aata ttggaaaata taggaaactt taaacgagaa aatgaaacct ctcataatcc cactgcatag aaataacaag cgttaacatt ttcatatttt tttctttcag tcatttttgt atttgtggta tatgtatata tgtacctata tgtatttgca tttgaaattt tggaatcctg ctctatgtac agttttgtat tatacttttt aaatcttgaa ctttatgaac attttctgaa atcattgatt attctacaaa aacatgattt taaacagctg taaaatattc tatgatatga atgttttatg cattatttaa gcctgtctct attgttggaa tttcaggtca ttt < 210> 34 < 211 > 247 < 212> DNA < 213 > Humans < 220 > < 223〉 Probe 1377_at HG-U95Av2 < 400〉 34 gtccacaaga cagaagctga agtgcatcca aaggtgctca gagagccggc ccgcctgaat cattctcgat ttaactcgag accttttcaa cttctga 60t tcctggtcc dtctgat 60 dtctgat 60a 120 200533758 ttttagtttg gttcacttac agatagtatc tagcaatcac aacactggct gagcggatgc at ctggggat gaggttgctt actaagcttt gccagctgct gctggatcac agctgctttc tgttgtc < 210 > 35 < 211 > 244 < 212〉 DNA < 213〉 human

<220> <223〉 Probe 1378_g—at HG-U95Av2 <400〉 35 agcccagtga agaccacctc tcaggcccac tcgctgcctc tctcgcctgc ctccacaagg cagcaaatag acgagctccg agacagtgac agtgtctgcg acacgggcgt ggagacatcc ttccgcaaac tcagctttac cgagtctctg accagtggtg cctcactgct aactctcaac aaaatgcccc atgattatgg gcaggaagga cctctagaag gcaaaattta gcctgctgac≪ 220 > < 223> Probe 1378_g-at HG-U95Av2 < 400> 35 agcccagtga agaccacctc tcaggcccac tcgctgcctc tctcgcctgc ctccacaagg cagcaaatag acgagctccg agacagtgac agtgtctgcg acacgggcgt ggagacatcc ttccgcaaac tcagctttac cgagtctctg accagtggtg cctcactgct aactctcaac aaaatgcccc atgattatgg gcaggaagga cctctagaag gcaaaattta gcctgctgac

<210> 36 <211> 571 <212〉 DNA <213> 人類 <220〉 <223> Probe 1385_at HG-U95Av2 <400〉 36 tgaagcacta caggaggaat gcaccacggc agctctccgc caatttctct cagatttcca 98677.doc -23 - 120 120< 210 > 36 < 211 > 571 < 212> DNA < 213 > Human < 220> < 223 > Probe 1385_at HG-U95Av2 < 400> 36 tgaagcacta caggaggaat gcaccacggc agctctccgc caatttctct ca. 120 120

200533758 cagagactgt ttgaatgttt tcaaaaccaa gtatcacact ttaatgtaca tgggccgcac cataatgaga tgtgagcctt gtgcatgtgg gggaggaggg agagagatgt actttttaaa tcatgttccc cctaaacatg gctgttaacc cactgcatgc agaaacttgg atgtcactgc ctgacattca cttccagaga ggacctatcc caaatgtgga attgactgcc tatgccaagt ccctggaaaa ggagcttcag tattgtgggg ctcataaaac atgaatcaag caatccagcc tcatgggaag tcctggcaca gtttttgtaa agcccttgca cagctggaga aatggcatca tiataagcta tgagttgaaa tgttctgtca aatgtgtctc acatctacac gtggcttgga ggcttttatg gggccctgtc caggtagaaa agaaatggta tgtagagctt agatttccct attgtgacag agccatggtg tgtttgtaat a <210> 37 <211〉 277 <212> DNA <213> 人類 <220〉 <223> Probe 1400_at HG-U95Av2 180 240 300 360 420 480 540 571 <400> 37 tctcctgaac agaaatgttt gggcctgcgg caagcagcac aagtttcaaa ctgagtagag gacctccagg ggcagcctca tgccctccaa gagaacctga acactgctgc agccgacctg ccaagctcaa ccccggaaac aggactttct tgagatgaat cctacagacc gggccccttg ttcctgtgca gcttgtc gaaacagtag cgcctggagc accatgatgg acccagatta aagtcatctc tgtacaagca ccagccacta tcacctttga 60 120 180 240 277 98677.doc -24- 200533758 <210> 38 <211> 348 <212> DNA <213>人類 <220> <223> Probe 1401_g—at HG-U95Av2200533758 cagagactgt ttgaatgttt tcaaaaccaa gtatcacact ttaatgtaca tgggccgcac cataatgaga tgtgagcctt tatgccaagt ccctggaaaa ggagcttcag tattgtgggg ctcataaaac atgaatcaag caatccagcc tcatgggaag tcctggcaca gtttttgtaa agcccttgca caggtagaaa agaaatggta tgtagagctt gtgcatgtgg gggaggaggg agagagatgt actttttaaa tcatgttccc cctaaacatg gctgttaacc cactgcatgc agaaacttgg atgtcactgc ctgacattca cttccagaga ggacctatcc caaatgtgga attgactgcc cagctggaga aatggcatca tiataagcta tgagttgaaa tgttctgtca aatgtgtctc acatctacac gtggcttgga ggcttttatg gggccctgtc agatttccct attgtgacag agccatggtg tgtttgtaat a < 210 > 37 < 211〉 277 < 212 > DNA < 213 > human < 220> < 223 > Probe 1400_at HG-U95Av2 180 240 300 360 420 480 540 571 < 400 > 37 tctcctgaac agaaatgttt gggcctgcgg caagcagcac aagtttcaca ctgagtagag gacctccagg ggcagcctca tgccctccaa gagaacctga acactgctgc agccgacctg ccaagctcaa ccgtcat gcctggcctcctacgcctcctgg ctc tgtacaagca ccagccacta tcacctttga 60 120 180 240 240 277 98677.doc -24- 200533758 < 210 > 38 < 211 > 348 < 212 > DNA < 213 > human < 220 > < 223 > Probe 1401_g-at HG- U95Av2

<400〉 38 cctgaaggac ccggccagat ctcaggatgg ggacctgccc atactgacag ttatttaagt tttctgcttg gaggctggcc tcatcttgga tgggccacac aaatcagtaa tcatattcca tcatcccctt aagccgggga gggaccaagg tgaccctgat tatttatata tatttattca tgactgctgg gctgctctct ggtgggccac acaggcatgg tttatatttt agatgtttta gagccagtcc catgaaacaa agccatggtg cagaagaatg taaaatattt ccgtaata aggagtgaga gagctagaaa ggagtggcct ggaatatttt atttatttat≪ 400> 38 cctgaaggac ccggccagat ctcaggatgg ggacctgccc atactgacag ttatttaagt tttctgcttg gaggctggcc tcatcttgga tgggccacac aaatcagtaa tcatattcca tcatcccctt aagccgggga gggaccaagg tgaccctgat tatttatata tatttattca tgactgctgg gctgctctct ggtgggccac acaggcatgg tttatatttt agatgtttta gagccagtcc catgaaacaa agccatggtg cagaagaatg taaaatattt ccgtaata aggagtgaga gagctagaaa ggagtggcct ggaatatttt atttatttat

<210〉 39 <211> 331 <212〉 DNA <213>人類 <220> <223> Probe 1402_at HG-U95Av2 <400> 39 ttgcacttat taaattactc ctccactcag gatttcatgt aggaagaaca ttgcaacttg gcggggatca ccctctaaat gacttgtcct tctgccgtgc gggaaagtat cagcagctgg ctggatcctg tctgtactct taatcttgct aaatagaggc tagatggatt ctgcttgaca 9S677.doc -25- 200533758 acatctgagt gcagccgttt gagaagaaaa catctattct ctccaaaaat gcacccaact agctctatgt ttacaaatgg acataggact caaagtttca gagaccattg caatgaatcc ccaataattg cagaactaaa ctcatttata a <210> 40 <211〉 64 <212〉 DNA <213>人類< 210> 39 < 211 > 331 < 212> DNA < 213 > human < 220 > < 223 > Probe 1402_at HG-U95Av2 < 400 > 39 ttgcacttat taaattactc ctccactcag gatttcatgt aggaagaca ggctgctgcc ctggcc ctggatcctg tctgtactct taatcttgct aaatagaggc tagatggatt ctgcttgaca 9S677.doc -25- 200533758 acatctgagt gcagccgttt gagaagaaaa catctattct ctccaaaaat gcacccaact agctctatgt ttacaaatgg acataggact caaagtttca gagaccattg caatgaatcc ccaataattg cagaactaaa ctcatttata a < 210 > 40 < 211> 64 < 212> DNA < 213 > human

<220〉 <223> Probe 1403_s—at HG-U95Av2 <400〉 40 gagcttctga ggcgctgctt tgtcaaaagg aagtctctag gttctgagct ctggctttgc cttg <210> 41 <211> 46 <212〉 DNA <213> 人類 <220〉 <223> Probe 1405^i__at HG-U95Av2 <400〉 41 agcttcccca actaaagcct agaagagctt ctgaggcgct gctttg <210〉 42 <211> 361 <212〉 DNA <213> 人類 9S677.doc -26- 60 60< 220> < 223 > Probe 1403_s-at HG-U95Av2 < 400> 40 gagcttctga ggcgctgctt tgtcaaaagg aagtctctag gttctgagct ctggctttgc cttg < 210 > 41 < 211 > 46 < 212> DNA 〉 ≪ 223 > Probe 1405 ^ i__at HG-U95Av2 < 400〉 41 agcttcccca actaaagcct agaagagctt ctgaggcgct gctttg < 210〉 42 < 211 > 361 < 212> DNA < 213 > human 9S677.doc -26-

200533758 <220> <223> Probe 1433_g„at HG-U95Av2 <400〉 42 cctctcagaa catactgatt gggaggtgcg tgttcagcag aacctgcaca caggacagcg ggaaaaatcg atgagcgcca cctctttaaa aactcactta cgttgtcctt tttcactttg aaaagttgga aggactgctg aggcccagtg catatgcaat gtatagtgtc tattatcaca tiaatctcaa agagattcga atgacggtaa gtgttctcat gaagcaggag gcccttgtcg tgggatggca tttggtctca ggcagcacca cactgggtgc gtctccagtc atctgtaaga gcttgctcca gattctgatg catacggcta tattggttta tgtagtcagt tgcattcatt a <210〉 43 <211> 499 <212〉 DNA <213>人類 <220> <223〉 Probe 1451—s_at HG-U95Av2 120 180 240 300 360 361 <400〉 43 gttgacttca aaatttaata gtggtaaagg gttctggcta caaatcgaag ggaactgaaa tttttttttc aattgaagaa actttggaat agttgtgaac catcagcaca tgaatgagaa aatataacac ccattagaga tgttatccca aagaagcaat acatgaggga cttacaccct aaaatccttg ttgaaaagac catcaaataa aattgtggag ttttcatctt tcaccagatt cgagccttgt ttctgaacac ttagcctcct gacattaaaa cattacaatt atgtatgtta 60 120 180 240 300 98677.doc •27- 200533758 tggatacata ggtgcttggt tttactggta atgcttcttg aaatgcacgc gtacaaaact aattatgtta caatgcata aagccattat ttttatatca ttttttacaa ctctccatgg aaaggctttg ctaattttgt gaagctaagt cacatttcta actctcagaa tataaaaata tatgagtggg tgtttgtcat200533758 < 220 > < 223 > Probe 1433_g "at HG-U95Av2 < 400> 42 cctctcagaa catactgatt gggaggtgcg tgttcagcag aacctgcaca caggacagcg ggaaaaatcg atgagcgcca cctctttaaa aactcactta cgttgtcctt tttcactttg aaaagttgga aggactgctg aggcccagtg catatgcaat gtatagtgtc tattatcaca tiaatctcaa agagattcga atgacggtaa gtgttctcat gaagcaggag gcccttgtcg tgggatggca tttggtctca ggcagcacca cactgggtgc gtctccagtc atctgtaaga gcttgctcca gattctgatg catacggcta tattggttta tgtagtcagt tgcattcatt a < 210> 43 < 211 > 499 < 212〉 DNA < 213 > human < 220 > < 223〉 Probe 1451-s_at HG 180 240 3002 3602 3602 ; 400> 43 gttgacttca aaatttaata gtggtaaagg gttctggcta caaatcgaag ggaactgaaa tttttttttc aattgaagaa actttggaat agttgtgaac catcagcaca tgaatgagaa aatataacac ccattagaga tgttatccca aagaagcaat acatgaggga cttacaccct aaaatccttg ttgaaaagac catcaaataa aattgtggag ttttcatctt tcaccagatt cgagccttgt ttctgaacac ttagcctcct gacattaaaa cattacaatt atgtatgtta 60 120 180 240 300 98677.doc • 27- 20053375 8 tggatacata ggtgcttggt tttactggta atgcttcttg aaatgcacgc gtacaaaact aattatgtta caatgcata aagccattat ttttatatca ttttttacaa ctctccatgg aaaggctttg ctaattttgt gaagctaagt cacatttcta actcta cagat tagata

<210> 44 <211> 523 <212> DNA <213>人類 <220> <223> Probe 1457一at HG-U95Av2 <400〉 44 caaacagcag ctaaaatatg ccgttcagat ttgtaagggg atggactatt tgggttctcg gcaatacgtt caccgggact tggcagcaag aaatgtcctt gttgagagtg aacaccaagt gaaaattgga gacttcggtt taaccaaagc aattgaaacc gataaggagt attacaccgt caaggatgac cgggacagcc ctgtgttttg gtatgctcca gaatgtttaa tgcaatctaa attttatatt gcctctgacg tctggtcttt tggagtcact ctgcatgagc tgctgactta ctgtgattca gattctagtc ccatggcttt gttcctgaaa atgataggcc caacccatgg ccagatgaca gtcacaagac ttgtgaatac gttaaaagaa ggaaaacgcc tgccgtgccc acctaactgt ccagatgagg tttatcagct tatgagaaaa tgctgggaat tccaaccatc caatcggaca agctttcaga accttattga aggatttgaa gca 98677.doc -28-< 210 > 44 < 211 > 523 < 212> gttgagagtg aacaccaagt gaaaattgga gacttcggtt taaccaaagc aattgaaacc gataaggagt attacaccgt caaggatgac cgggacagcc ctgtgttttg gtatgctcca gaatgtttaa tgcaatctaa attttatatt gcctctgacg tctggtcttt tggagtcact ctgcatgagc tgctgactta ctgtgattca gattctagtc ccatggcttt gttcctgaaa atgataggcc caacccatgg ccagatgaca gtcacaagac ttgtgaatac gttaaaagaa ggaaaacgcc tgccgtgccc acctaactgt ccagatgagg tttatcagct tatgagaaaa tgctgggaat tccaaccatc caatcggaca agctttcaga accttattga aggatttgaa gca 98677.doc -28-

200533758 <210〉 45 <211> 577 <212〉 DNA <213〉人類 <220> <223〉 Probe 1461_at HG-U95Av2 <400〉 45 tcagatgctg ccagagagtg aggatgagga gagctatgac acagagtcag agttcacgga gttcacagag gacgagctgc cctatgatga ctgtgtgtit ggaggccagc gtctgacgtt atgagtgcaa aggggctgaa agaacatgga cttgtatatt tgtacaaaaa aaaagtttta tttttctaaa aaaagaaaaa agaagaaaaa atttaaaggg tgtacttata tccacactgc acactgccta gcccaaaacg tcttattgtg gtaggatcag ccctcatttt gttgcttttg tgaacttttt gtaggggacg agaaagatca ttgaaattct gagaaaactt cttttaaacc tcacctttgt ggggtttttg gagaaggtta tcaaaaattt catggaagga ccacatttta tatttattgt gcttcgagtg actgacccca gtggtatcct gtgacatgta acagccagga gtgttaagcg ttcagtgatg tggggtgaaa agttactacc tgtcaaggtt tgtgttaccc tcctgtaaat ggtgtacata atgtattgtt ggtaatt <210〉 46 <211> 611 <212〉 DNA <213>人類 <220〉 <223> Probe 1520丄at HG-U95Av2 60 120 180 240 300 360 420 480 540 577 98677.doc -29- 60 60200533758 < 210> 45 < 211 > 577 < 212> DNA < 213〉 human < 220 > < 223〉 Probe 1461_at HG-U95Av2 < 400> 45 tcagatgctg ccagagagtg aggatgagga gagctatgac acagagtcag ggtctccggtctca gtctgacgtt atgagtgcaa aggggctgaa agaacatgga cttgtatatt tgtacaaaaa aaaagtttta tttttctaaa aaaagaaaaa agaagaaaaa atttaaaggg tgtacttata tccacactgc acactgccta gcccaaaacg tcttattgtg gtaggatcag ccctcatttt gttgcttttg tgaacttttt gtaggggacg agaaagatca ttgaaattct gagaaaactt cttttaaacc tcacctttgt ggggtttttg gagaaggtta tcaaaaattt catggaagga ccacatttta tatttattgt gcttcgagtg actgacccca gtggtatcct gtgacatgta acagccagga gtgttaagcg ttcagtgatg tggggtgaaa agttactacc tgtcaaggtt tgtgttaccc tcctgtaaat ggtgtacata atgtattgtt ggtaatt < 210 〉 46 < 211 > 611 < 212〉 DNA < 213 > human < 220> < 223 > Probe 1520 丄 at HG-U95Av2 60 120 180 240 300 360 420 480 540 577 98677.doc -29- 60 60

200533758 <400> 46 acttcaccat gcaatttgtg tcttcctaaa gagagctgta cccagagagt cctgtgctga atgtggactc aatccctagg gctggcagaa agggaacaga aaggtttttg agtacggcta tagcctggac tttcctgttg tctacaccaa tgcccaactg cctgccttag ggtagtgcta agaggatctc ctgtccatca gccaggacag tcagctctct cctttcaggg ccaatcccca gcccttttgt tgagccaggc ctctctcacc tctcctactc acttaaagcc cgcctgacag aaaccacggc cacatttggt tctaagaaac cctctgtcat tcgctcccac attctgatga gcaaccgctt ccctatttat ttatttattt gtttgtttgt tttgattcat tggtctaatt tattcaaagg gggcaagaag tagcagtgtc tgtaaaagag cctagttttt aatagctatg gaatcaattc aatttggact ggtgtgctct ctttaaatca agtcctttaa ttaagactga aaatatataa gctcagatta tttaaatggg aatatttata aatgagcaaa tatcatactg ttcaatggtt c <210> 47 <211〉 328 <212〉 DNA <213>人類 <220〉 <223〉 Probe 1561一at HG-U95Av2 120 180 240 300 360 420 480 540 600 611 <400〉 47 gtgctgtttg cggcggcggg ccggccccgg cgcccttcgg aggcagcgag agacgcagtt ccgggcgggc ggctgagccc caagcgccgc gccccgggac cgggacgcgc agctgccaga caggcggcgg ggaccggctg tggagttcga cagcgacctg gcccgaggag ggagggcatg 60 120 180 98677.doc -30- 200533758 gtggaggggc gcgcgcgcgg cgaggagctg gccgccctgg gcaagcaggc gagcttctcg ggcagcgtgg aggtcatcga ggtgtcctga cccctccgct gccctcggcc ccgccgcccg cagccaggcc cgttataaat gtatatta <210> 48 <211> 212 <212> DNA <213〉人類200533758 < 400 > 46 acttcaccat gcaatttgtg tcttcctaaa gagagctgta cccagagagt cctgtgctga atgtggactc aatccctagg gctggcagaa agggaacaga aaggtttttg agtacggcta tagcctggac tttcctgttg tctacaccaa tgcccaactg cctgccttag ggtagtgcta agaggatctc ctgtccatca gccaggacag tcagctctct cctttcaggg ccaatcccca gcccttttgt tgagccaggc ctctctcacc tctcctactc acttaaagcc cgcctgacag aaaccacggc cacatttggt tctaagaaac cctctgtcat tcgctcccac attctgatga gcaaccgctt ccctatttat ttatttattt gtttgtttgt tttgattcat tggtctaatt tattcaaagg gggcaagaag tagcagtgtc tgtaaaagag cctagttttt aatagctatg gaatcaattc aatttggact ggtgtgctct ctttaaatca agtcctttaa ttaagactga aaatatataa gctcagatta tttaaatggg aatattt <218;218; lt <218; lt < 218 <218; lt < 218 > ltlt > ltcaatgg < 218 < 218 < 210 < 218 < 210 < 210 > < 210 HG-U95Av2 120 180 240 300 360 420 480 540 600 611 < 400〉 47 gtgctgtttg cggcggcggg ccggccccgg cgcccttcgg aggcagcgag agacgcagtt ccgggcgggc ggctgagccc caagcgccgc agccgggggggggggcc ggcgg ggaccggctg tggagttcga cagcgacctg gcccgaggag ggagggcatg 60 120 180 98677.doc -30- 200533758 gtggaggggc gcgcgcgcgg cgaggagctg gccgccctgg gcaagcaggc gagcttctcg ggcagcgtgg aggtcatcga ggtgtcctga cccctccgct gccctcggcc ccgccgcccg cagccaggcc cgttataaat gtatatta < 210 > 48 < 211 > 212 < 212 > DNA < 213> Humanity

<223> Probe 1562—g—at HG-U95Av2 <400〉 48 tatttaagct gttcattctg gcaatgattt ggcaacagtg cgggtggtcc tcgagctcta tttttactgt ctggtattta aactgaaaca tacgtttcta agcaatacga ggccaccttc agtcgcaagc tgggtgccag gcctggggcc ctcccagttc ccccgcccca ggaaacactg ctgacctttg caaaggctgc cgagctttcg tg≪ 223 > Probe 1562-g-at HG-U95Av2 < 400> 48 tatttaagct gttcattctg gcaatgattt ggcaacagtg cgggtggtcc tcgagctcta tttttactgt ctggtattta aactgaaaca tacgtttcta agcaatacga ggccaccttc agtcgcaagc tgggtgccag gcctggggcc ctcccagttc ccccgcccca ggaaacactg ctgacctttg caaaggctgc cgagctttcg tg

<210> 49 <211> 541 <212> DNA <213> 人類 <220> <223〉 Probe 1573—at HG-U95Av2 <400〉 49 aaggacattg tatgcaggga gcactgttca catcatagat aaagctgatt tgtatattta ttatgacaat ttctggcaga tgtaggtaaa gaggaaaagg atccttttcc taattcacac 98677.doc -31 - 200533758 aaagactcct tgtggactgg ctgtgcccct gatgcagcct gtggctggag tggccaaata 180 ggagggagac tgtggtaggg gcagggaggc aacactgctg tccacatgac ctccatttcc 240 caaagtcctc tgctccagca actgcccttc caggtgggtg tgggacacct gggagaaggt 300 ctccaaggga gggtgcagcc ctcttgcccg cacccctccc tgcttgcaca cttccccatc 360 tttgatcctt ctgagctcca cctctggtgg ctcctcctag gaaaccagct cgtgggctgg 420 gaarggggga gagaagggaa aagatcccca agaccccctg gggtgggatc tgagctccca 480 cctcccttcc cacctactgc actttccccc ttcccgcctt ccaaaacctg cttccttcag 540 t 541 <210〉 50 <211〉 247 <212> DNA <213> 人類 <220〉 <223> Probe 1577—at HG-U95Av2 <400〉 50 catggaattc tatttgctgg gctttttttt tctctttctc tcctttcttt ttcttcttcc 60 ctccctatct aaccctccca tggcaccttc agactttgct tcccattgtg gctcctatct 120 gtgttttgaa tggtgttgta tgcctttaaa tctgtgatga tcctcatatg gcccagtgtc 180 aagttgtgct tgtttacagc actactctgt gccagccaca caaacgttta cttatcttat 240 gccacgg 247 m^l.doc -32- 200533758 <210> 51 <211〉 391 <212> DNA <213〉人類 <220〉 <223〉 Probe 158一at HG-U95Av2 <400> 51 gcaccaaaat tacttttcca agagaaggag atgaaaacac caaatagtat tccagcagac attgttttta tcattaaaga caaagatcat ccaaaattta aaagggatgg atcaaatata atttactgct aaaattagtt tacgagagga gattgtgtgg cgtgctcaat taatgtacca acactggatg gaagaacata cctatgtcag taaatgatat tgtgaacccg gaatgaggag aagaattatt ggatatgggc tgccatttcc aaaaaatcct gaccaacgtg gtgaccttct aatagaattt gaggtgtcct tcccagatac tatatcttct tcatggaaag aagtactaga catctccgcc tcatagaatg agacttgtag a <210〉 52 <211〉 181 <212〉 DNA <213>人類 <220〉 <223> Probe 1591—s—at HG-U95Av2 <400〉 52 ggacgtttcc tcctgaccca atcgggctga atcaggttcc gtccccgtgc ggaagcacag atcccgaaaa cccgcctccc cagcatcttc tctctcggtt cgaaacaggc aaacatgtac ccacgtcccc tactctcctc aaaatcgatt ctggggcttc ggccccctcc ggctttaaac 98677.doc '33 -. 200533758 a 181 <210〉 53 <211> 331 <212〉 DNA <213>人類 <220〉 <223> Probe 159一at HG-U95Av2 <400〉 53 gtactgtttt ccagttcatc gattttctat tatggaaaac tgtgttgcca cagtagaact 60 gtctgtgaac agagagaccc ttgtgggtcc atgctaacaa agacaaaagt ctgtctttcc 120 tgaaccatgt ggataacttt acagaaatgg actggagctc atctgcaaaa ggcctcttgt 180 aaagactggt tttctgccaa tgaccaaaca gccaagattt tcctcttgtg atttctttaa 240 aagaatgact atataattta tttccactaa aaatattgtt tctgcattca tttttatagc 300 aacaacaatt ggtaaaactc actgtgatca a 331 <210> 54 <211> 333 <212> DNA <213> 人類 <220> <223〉 Probe 1633一g—at HG-U95Av2 <400〉 54 tgttatccca agtgctctta ttctggtgag aagaacctta attccataat ttgggaagga 60 atggaagatg gacaccaccg gacaccacca gacaatagga tgggatggat ggttttttgg 120 98677.doc -34- 200533758 gggatgggct aggggaaata aggcttgctg tttgttttcc tggggcgctc cctccaattt 180 tgcagatttt tgcaacctcc tcctgagccg ggattgtcca attactaaaa tgtaaataat 240 cacgtattgt ggggagggga gttccaagtg tgccctcctt ttttttcctg cctggattat 300 ttaaaaagcc atgtgtggaa acccactatt taa 333 <210> 55 <21i> 445 <212〉 DNA <213> 人類 <220〉 <223〉 Probe 1637—at HG-U95Av2 <400〉 55 tgacaaaagc cagcatactt tccctgcacc catctgctca ccagatctca ggcaggaaag 60 cccctctctg ttgaagtcag gggctatctt ttggtatact tgtgtgaaag tggctggttg 120 ggagcagagc taagtggctt cccattaacc tgaggtctct ttctttactc tgggtcagac 180 ctgaggttgg ggaaggcgac tgagccatgc tcagaatgtc tggtcctggc ttgggcctga 240 gtagggcaga gagggccttt catggctgat cagagcttac cagccccacc ccaccatggt 300 agccttaggg tgctgagtgc ctgatactgc ctgacaagtg cctgacacgc agcctagttc 360 cttcctggcc cctctctcac tggctgggaa accctagacc atgtcagata ggacaacact 420 gctgggtttt acatccagat agtaa 445 <210〉 56 <211> 196 98677.doc •35- 200533758 <212〉 DNA <213> 人類 <220> <223> Probe 1652_at HG-U95Av2 <400> 56< 210 > 49 < 211 > 541 < 212 > DNA < 213 > human < 220 > < 223〉 Probe 1573-at HG-U95Av2 < 400〉 49 aaggacattg tatgcaggga gcactgttca catcatagat aaagctgatt tctagatagatagat atccttttcc taattcacac 98677.doc -31 - 200533758 aaagactcct tgtggactgg ctgtgcccct gatgcagcct gtggctggag tggccaaata 180 ggagggagac tgtggtaggg gcagggaggc aacactgctg tccacatgac ctccatttcc 240 caaagtcctc tgctccagca actgcccttc caggtgggtg tgggacacct gggagaaggt 300 ctccaaggga gggtgcagcc ctcttgcccg cacccctccc tgcttgcaca cttccccatc 360 tttgatcctt ctgagctcca cctctggtgg ctcctcctag gaaaccagct cgtgggctgg 420 gaarggggga gagaagggaa aagatcccca agaccccctg gggtgggatc tgagctccca 480 cctcccttcc cacctactgc actttccccc ttcccgcctt ccaaaacctg cttccttcag 540 t 541 < 210〉 50 < 211〉 247 < 212 > DNA < 213 > human < 220〉 < 223 > Probe 1577--at HG-U95Av2 50 catggaattc tatttgctgg gctttttttt tctctttctc tcctttcttt ttcttcttcc 60 ctccctatct aaccctccca tggcaccttc agactttgct tcccattgtg gctcctatct 120 gtgttttgaa tggtgttgta tgcctttaaa tctgtgatga tcctcatatg gcccagtgtc 180 aagttgtgct tgtttacagc &212;210;247;210;mgt-247; mgt-210 < 220> < 223> Probe 158 a at HG-U95Av2 < 400 > 51 gcaccaaaat tacttttcca agagaaggag atgaaaacac caaatagtat tccagcagac attgttttta tcattaaaga caaagatcat ccaaaattta aaagggatgg atcaaatata atttactgct aaaattagtt tacgagagga gattgtgtgg cgtgctcaat taatgtacca acactggatg gaagaacata cctatgtcag taaatgatat tgtgaacccg gaatgaggag aagaattatt ggatatgggc tgccatttcc aaaaaatcct gaccaacgtg gtgaccttct aatagaattt gaggtgtcct tcccagatac tatatcttct tcatggaaag aagtactaga catctccgcc tcatagaatg agacttgtag a < 210〉 52 < 211〉 181 < 212〉 DNA < 213 > human < 220> < 223 > Probe 1591-95-at-HG-at 〉 52 ggacgtttcc tcctgaccca atcgggctga atcaggttcc gtccccgtgc ggaagcacag atcccgaaaa cccgcctccc cag catcttc tctctcggtt cgaaacaggc aaacatgtac ccacgtcccc tactctcctc aaaatcgatt ctggggcttc ggccccctcc ggctttaaac 98677.doc '33-. 200533758 a 181 < 210> 53 < 211 > 331 < 220> > < 159 < 159 one at HG-U95Av2 < 400> 53 gtactgtttt ccagttcatc gattttctat tatggaaaac tgtgttgcca cagtagaact 60 gtctgtgaac agagagaccc ttgtgggtcc atgctaacaa agacaaaagt ctgtctttcc 120 tgaaccatgt ggataacttt acagaaatgg actggagctc atctgcaaaa ggcctcttgt 180 aaagactggt tttctgccaa tgaccaaaca gccaagattt tcctcttgtg atttctttaa 240 aagaatgact atataattta tttccactaa aaatattgtt tctgcattca tttttatagc 300 aacaacaatt ggtaaaactc actgtgatca a 331 < 210 > 54 < 211 > 333 < 212 > DNA < 213 > human < 220 > < 223〉 Probe 1633-g-at HG-U95Av2 < 400> 54 tgttatccca agtgctctta ttctggtgag aagaacctta attccatag 60g gacaccaccg gacaccacca gacaatagga tgggatggat ggttttttgg 120 98677.doc -34- 200533758 gggatgggct aggggaaata aggcttgctg tttgttttcc tggggc gctc cctccaattt 180 tgcagatttt tgcaacctcc tcctgagccg ggattgtcca attactaaaa tgtaaataat 240 cacgtattgt ggggagggga gttccaagtg tgccctcctt ttttttcctlt &220; <220; <220; < < 220 > < 220 < < > < < > < < 220 > <> Probe 1637-at HG-U95Av2 < 400> 55 tgacaaaagc cagcatactt tccctgcacc catctgctca ccagatctca ggcaggaaag 60 cccctctctg ttgaagtcag gggctatctt ttggtatact tgtgtgaaag tggctggttg 120 ggagcagagc taagtggctt cccattaacc tgaggtctct ttctttactc tgggtcagac 180 ctgaggttgg ggaaggcgac tgagccatgc tcagaatgtc tggtcctggc ttgggcctga 240 gtagggcaga gagggccttt catggctgat cagagcttac cagccccacc ccaccatggt 300 agccttaggg tgctgagtgc ctgatactgc ctgacaagtg cctgacacgc agcctagttc 360 cttcctggcc cctctctcac tggctgggaa accctagacc atgtcagata ggacaacact 420 gctgggtttt acatccagat agtaa 445 < 210> 56 < 211 > 196 98677.doc; 35 < 223 < 223 <lt;lt; 35 > > 2005 <lt;gt; > Probe 1652_at HG-U95Av2 < 400 > 56

caccacacaa acttagttca tatgctttta cttgggcaag ggtgctttcc ttccaatacc ccagtagctt ttattttagt aaagggaccc tttcccctag cctagggtcc catattgggt caagctgctt acctgcctca gcccaggatt ttttattttg ggggaggtaa tgccctgttg ttaccccaag gcttct <210〉 57 <211> 559 <212〉 DNA <213> 人類 <220〉 <223〉 Probe 1669—at HG-U95Av2 <400〉 57 tcagcccact acatagatag cttttttttt tttttttttt ttttaataag gacacctctt tccaaacagg ccatcaaata tgttcttatc tcagacttac gttgttttaa aagtttggaa agatacacat cttttcatac ccccccttag gaggttgggc tttcatatca cctcagccaa ctgtggctct taatttattg cataatgata tccacatcag ccaactgtgg ctctttaatt tattgcataa tgatattcac atcccctcag ttgcagtgaa ttgtgagcaa aagatcttga aagcaaaaag cactaattag tttaaaatgt cacttttttg gtttttatta tacaaaaacc atgaagtact ttttttattt gctaaatcag attgttcctt tttagtgact catgtttatg 98677.doc -36- 200533758 aagagagttg agtttaacaa tcctagcttt taaaagaaac tatttaatgt aaaatattct acatgtcatt cagatattat gtatatcttc tagcctttat tctgtacttt taatgtacat atttctgtct tgcgtgatt <210> 58 <211> 475 <212〉 DNA <213> 人類caccacacaa acttagttca tatgctttta cttgggcaag ggtgctttcc ttccaatacc ccagtagctt ttattttagt aaagggaccc tttcccctag cctagggtcc catattgggt caagctgctt acctgcctca gcccaggatt ttttattttg ggggaggtaa tgccctgttg ttaccccaag gcttct < 210> 57 < 211 > 559 < 212> DNA < 213 > human < 220> < 223> Probe 1669 -at HG-U95Av2 < 400> 57 tcagcccact acatagatag cttttttttt tttttttttt ttttaataag gacacctctt tccaaacagg ccatcaaata tgttcttatc tcagacttac gttgttttaa aagtttggaa agatacacat cttttcatac ccccccttag gaggttgggc tttcatatca cctcagccaa ctgtggctct taatttattg cataatgata tccacatcag ccaactgtgg ctctttaatt tattgcataa tgatattcac atcccctcag ttgcagtgaa ttgtgagcaa aagatcttga aagcaaaaag cactaattag tttaaaatgt cacttttttg gtttttatta tacaaaaacc atgaagtact ttttttattt gctaaatcag attgttcctt tttagtgact catgtttatg 98677.doc -36- 200533758 aagagagttg agtttaacaa tcctagcttt taaaagaaac tatttaatgt aaaatattct acatgtcatt cagatattat gtatatcttc tagcctttat tctgtact & taatgtacat atttctgtct tg210gt <; 211 > 475 < 212〉 DNA < 213 > human

<220〉 <223> Probe 1674_at HG-U95Av2 <400> 58 gaagatggac ttcatgcaag ttggcagtgg ttctggtact aaaaattgtg gttgtttttt ctgtttacgt aacctgctta gtattgacac tctctaccaa gagggtcttc ctaagaagag tgctgtcatt atttcctctt atcaacaact tgtgacatga gattttttaa gggctttatg tgaactatga tattgtaatt tttctaagca tattcaaaag ggtgacaaaa ttacgtttat gtactaaatc taatcaggaa agtaaggcag gaaaagttga tggtatteat taggttttaa ctgaatggag cagttcctta tataataaca attgtatagt agggataaaa cactaacaat gtgtattcat tttaaattgt tctgtatttt taaattgcca agaaaaacaa ctttgtaaat ttggagatat tttccaacag cttttcgtct tcagtgtctt aatgtggaag ttaac <210〉 59 <211> 416 <212> DNA <213>人類 98677.doc -37- 200533758 <220〉 <223〉 Probe 1717一s—at HG-U95Av2 <220〉 <221> misc_feature <222〉 （330)..(330) <223〉n 為 a，g，c 或 t <220〉 <221〉 <222> <223〉≪ 220> < 223 > Probe 1674_at HG-U95Av2 < 400 > 58 gaagatggac ttcatgcaag ttggcagtgg ttctggtact aaaaattgtg gttgtttttt ctgtttacgt aacctgctta gtattgacac tctctaccaa gagggtcttc ctaagaagag tgctgtcatt atttcctctt atcaacaact tgtgacatga gattttttaa gggctttatg tgaactatga tattgtaatt tttctaagca tattcaaaag ggtgacaaaa ttacgtttat gtactaaatc taatcaggaa agtaaggcag gaaaagttga tggtatteat taggttttaa ctgaatggag cagttcctta tataataaca attgtatagt agggataaaa cactaacaat gtgtattattcat tttaaattgt tctgtatttt taaattgcca agaaaaacaa ctttgtaaat ttggagatat tttccaacag cttttcgtct tcagtgtctt human <210; ltlt <210; ltlt <210; < 212 〉 Probe 1717-s-at HG-U95Av2 < 220> < 221 > misc_feature < 222〉 (330) .. (330) < 223〉 n is a, g, c or t < 220> < 221〉 < 222 > < 223〉

misc一feature (336)..(336) n 為 a，g，c 或 t <220〉 <221> misc_feature <222〉 （343)..(343) <223> n 為 a，g，c 或 tmisc-feature (336) .. (336) n is a, g, c or t < 220〉 < 221 > misc_feature < 222〉 (343) .. (343) < 223 > n is a, g , C or t

<400> 59 atatatgtat ttgttcttat cattattgaa taaatatttt tgtagtccca cagcatactg atttctctgt ctaaaccata gaacgaaaaa attgtaagtg ggcattgtac ggctgaggca agaccctgcc cttttttgat tgaacatata gaggtagcac aagtaaaact taataccggg agagaattac tttaaaaacn cagtgtccta ttttttagaa tacaaacaca taagatattt aacatgaagc ttgagcccag aacagnacca tacatcgaag actaagagaa atattcaatc gagttaacct caggtgtggt gagtttgaat aanccaaaca gtgtgcatat tgataggctt caaatttcag ttaagaattt ggtatgtacc ccatcctggg ccagggacac atgttg 60 120 180 240 300 360 98677.doc 38- 416≪ 400 > 59 atatatgtat ttgttcttat cattattgaa taaatatttt tgtagtccca cagcatactg atttctctgt ctaaaccata gaacgaaaaa attgtaagtg ggcattgtac ggctgaggca agaccctgcc cttttttgat tgaacatata gaggtagcac aagtaaaact taataccggg agagaattac tttaaaaacn cagtgtccta ttttttagaa tacaaacaca taagatattt aacatgaagc ttgagcccag aacagnacca tacatcgaag actaagagaa atattcaatc gagttaacct caggtgtggt gagtttgaat aanccaaaca gtgtgcatat tgataggctt caaatttcag ttaagaattt ggtatgtacc ccatcctggg ccagggacac atgttg 60 120 180 240 300 360 98677.doc 38- 416

200533758 <210〉 60 <211> 556 <212〉 DNA <213>人類 <220〉 <223> Probe 1737_s—at HG-U95Av2 <400〉 60 aagagacatg taccttgacc atcgtccttc ctctcaagct agccagaggg tgggagccta aggaagcgtg gggtagcaga tggagtaatg gtcacgaggt ccagacccac tcccaaagct cagacttgcc aggctccctt tctcttcttc cccaggtcct tcctttaggt ctggttgttg caccatctgc ttggttggct ggcagctgag agccctgctg tgggagagcg aagggggtca aaggaagact tgaagcacag agggctaggg aggtggggta catttctctg agcagtcagg gtgggaagaa agaatgcaag agtggactga atgtgcctaa tggagaagac ccacgtgcta ggggatgagg ggcttcctgg gtcctgttcc ctaccccatt tgtggtcaca gccatgaagt caccgggatg aacctatcct tccagtggct cgctccctgt agctctgcct ccctctccat atctccttcc cctacacctc cctccccaca cctccctact cccctgggca tcttctggct tgactggatg gaagga <210〉 61 <211> 385 <212> DNA <213〉人類 <220〉 <223〉 Probe 1761一at HG-U95Av2 60 120 180 240 300 360 420 480 540 556 98677.doc -39- 200533758 <400〉 61 gaggttgatc cacagaggac tgggacacac cacgagaatc tcccagagtg tcattacagt 60 ggaagacttc gagacgattg atgcaggata ttacatttgc actgctcaga atcttcaagg 120 acagaccaca gtagctacca ctgttgagtt ttcctgactt ggaaaaggaa atgtaatgaa 180 cttatggaaa gcccatttgt gtacacagtc agctttgggg ttccttttat tagtgctttg 240 ccagaggctg atgtcaagca ccacacccca accccagcgt ctcgtgagtc cgacccagac 300 atccaaacta aaaggaagtc atccagtcta ttcacagaag tgttaacttt tctaacagaa 360200533758 < 210> 60 < 211 > 556 < 212> DNA < 213 > human < 220> < 223 > Probe 1737_s-at HG-U95Av2 < 400> 60 aagagacatg taccttgacc atcgtccttc ctctcaagct agccagaggg tgggatggggg tggga gtcacgaggt ccagacccac tcccaaagct cagacttgcc aggctccctt tctcttcttc cccaggtcct tcctttaggt ctggttgttg caccatctgc ttggttggct ggcagctgag agccctgctg tgggagagcg aagggggtca aaggaagact tgaagcacag agggctaggg aggtggggta catttctctg agcagtcagg gtgggaagaa agaatgcaag agtggactga atgtgcctaa tggagaagac ccacgtgcta ggggatgagg ggcttcctgg gtcctgttcc ctaccccatt tgtggtcaca gccatgaagt caccgggatg aacctatcct tccagtggct cgctccctgt agctctgcct ccctctccat atctccttcc cctacacctc cctccccaca cctccctact cccctgggca tcttctggct tgactggatg gaagga < 210 〉 61 < 211 > 385 < 212 > DNA < 213〉 Human < 220〉 < 223〉 Probe 1761-at HG-U95Av2 60 120 180 240 300 360 420 480 540 556 98677.doc -39- 200533758 < 400〉 61 gaggttgatc cacagaggac tgggacacac cacgagaatc tcccagagtg tcatta cagt 60 ggaagacttc gagacgattg atgcaggata ttacatttgc actgctcaga atcttcaagg 120 acagaccaca gtagctacca ctgttgagtt ttcctgactt ggaaaaggaa atgtaatgaa 180 cttatggaaa gcccatttgt gtacacagtc agctttgggg ttccttttat tagtgctttg 240 ccagaggctg atgtcaagca ccacacccca accccagcgt ctcgtgagtc cgacccagac 300 atccaaacta aaaggaagtc atccagtcta ttcacagaag tgttaacttt tctaacagaa 360

agcatgattt tgattgctta cctac 385 <210〉 62 <211〉 371 <212〉 DNA <213>人類 <220> <223〉 Probe 1778一g—at HG-U95Av2 <400〉 62 cagtgggcag tcagaggcaa gaagcagagg ggaggagcaa gggtgccagg gagatgggga 60 tgctggggtc aaagccagcc ccagggacat tcgggaacag tctgagacaa ctgctgaagg 120 gggccagggt caagcccagg aaggccctgc tcagccaggg gaaccagagg cagagggaag 180 ccgggcagca gaggagtagc ttgaagtggc cagaagggtc attcggggcg ggagaccctg 240 agcctgctga gaaatccttt tagcgccagc aagccccacc cagggccctg tcctgtgtct 300 gccaccacct ttgtctgata cttgtttcca gggaagctgg gggaactgcc acatctgagg 360 aactggaata a 371 98677.doc -40- 200533758 <210〉 63 <211> 437 <212〉 DNA <213> 人類 <220> <223> Probe 1788一s—at HG-U95Av2 <400〉 63agcatgattt tgattgctta cctac 385 < 210〉 62 < 211〉 371 < 212〉 DNA < 213 > human < 220 > < 223〉 Probe 1778-g—at HG-U95Av2 < 400〉 62 cagtgggcag tcagaggcaa gaagcagagg gg gggtgccagg gagatgggga 60 tgctggggtc aaagccagcc ccagggacat tcgggaacag tctgagacaa ctgctgaagg 120 gggccagggt caagcccagg aaggccctgc tcagccaggg gaaccagagg cagagggaag 180 ccgggcagca gaggagtagc ttgaagtggc cagaagggtc attcggggcg ggagaccctg 240 agcctgctga gaaatccttt tagcgccagc aagccccacc cagggccctg tcctgtgtct 300 gccaccacct ttgtctgata cttgtttcca gggaagctgg gggaactgcc acatctgagg 360 aactggaata a 371 98677.doc -40- 200533758 < 210> 63 < 211 > 437 < 212> DNA < 213 > Human < 220 > < 223 > Probe 1788-s-at HG-U95Av2 < 400> 63

agtgatgaaa cccacagatc ctagcaaatg tgcccaacca gctttactaa agggggagga agggagggca aagggatgag aagacaagtt tcccagaagt gcctggttct gtgtacttgt ccctttgttg tcgtcgttgt agttaaagga atttcatttt ttaaaagaaa tcttcgaagg tgtggttttc atttctcagt caccaacaga tgaataatta tgcttaataa taaagtattt attaagactt tcttcagagt atgaaagtac aaaaagtcta gttacagtgg atttagaata tatttatgtt gatgtcaaac agctgagcac cgtagcatgc agatgtcaag gcagttagga agtaaatcgg tgtcttgtag atatgtgcaa ggtagcatga tgagcaactt gagtttgttgagtgatgaaa cccacagatc ctagcaaatg tgcccaacca gctttactaa agggggagga agggagggca aagggatgag aagacaagtt tcccagaagt gcctggttct gtgtacttgt ccctttgttg tcgtcgttgt agttaaagga atttcatttt ttaaaagaaa tcttcgaagg tgtggttttc atttctcagt caccaacaga tgaataatta tgcttaataa taaagtattt attaagactt tcttcagagt atgaaagtac aaaaagtcta gttacagtgg atttagaata tatttatgtt gatgtcaaac agctgagcac cgtagcatgc agatgtcaag gcagttagga agtaaatcgg tgtcttgtag atatgtgcaa ggtagcatga tgagcaactt gagtttgttg

ccactgagaa gcaggcg <210> 64 <211〉 307 <212> DNA <213〉人類 <220〉 <223〉 Probe 1798—at HG-U95Av2 <4〇0> 64 tagtttatgt atcaccagac tgggttattg ccaagttata tatcaccaaa agctgtatga 98677.doc -41 - 200533758 ctggatgttc gaggatatta ctcagtgctt ctaggcctgt agcttga tggttacctg aaactacact cagtgctatc ctgtggcatt gtttacaaaa aagtatcatt attgtgagca ctctagatgt ttatcagagt tgattcgatt attgtcttta ttctttttta agtaaaactt cagaaagtac tatacggtac cacaataaat tgatatatat tttgatatct tgtagccata tccttatatcccactgagaa gcaggcg < 210 > 64 < 211〉 307 < 212 > DNA < 213〉 human < 220〉 < 223〉 Probe 1798-at HG-U95Av2 < 4〇0 > 64 tagtttatgt atcaccagac tgggttattg ccaagttata tctca 98677.doc -41 - 200533758 ctggatgttc gaggatatta ctcagtgctt ctaggcctgt agcttga tggttacctg aaactacact cagtgctatc ctgtggcatt gtttacaaaa aagtatcatt attgtgagca ctctagatgt ttatcagagt tgattcgatt attgtcttta ttctttttta agtaaaactt cagaaagtac tatacggtac cacaataaat tgatatatat tttgatatct tgtagccata tccttatatc

<210〉 65 <211〉 331 <212〉 DNA <213>人類 <220〉 <223> Probe 1845一at HG-U95Av2 <400> 65 agacattgct ctatgtctgc cttcgaccac agcaagccat catcctccat tgctcccggg gactcaagag gaatctgttt ctctgctgtc aacttcccat ctggctcagc atagggtcac tttgccatta tgcaaatgga gataaaagca attctggctg tccaggagct aatctgaccg ttctattgtg tggatgacca cataagaagg caattttagt gtattaatca tagattatta taaactataa acttaagggc aaggagttta ttacaatgta tctttattaa aacaaaaggg tgtatagtgt tcacaaactg tgaaaatagt g <210> 66 <211> 193 <212〉 DNA <213> 人類 98677.doc -42- 200533758 <220> <223〉 Probe 1867—at HG-U95Av2 <400> 66 taacacccta tgcccattgt cctgatctga aaattcttgg aaattgttcc atgtgattaa 60 catggaactg cctctactta atcattctga atgattaaat cgtttcattt tctaaatgtg 120 ttataatgtg tttagccctt tcttgttgct gtatgtttag atgctttcca atcttttgtt 180 actactaata atg 193< 210〉 65 < 211〉 331 < 212〉 DNA < 213 > human < 220〉 < 223 > Probe 1845a at HG-U95Av2 < 400 > 65 agacattgct ctatgtctgc cttcgaccac agcaagccat catcctccat tgctcctctgcctgctcccgg ctggctcagc atagggtcac tttgccatta tgcaaatgga gataaaagca attctggctg tccaggagct aatctgaccg ttctattgtg tggatgacca cataagaagg caattttagt gtattaatca tagattatta taaactataa acttaagggc aaggagttta ttacaatgta tctttattaa aacaaaaggg tgtatagtgt tcacaaactg tgaaaatagt g < 210 > 66 < 211 > 193 < 212> DNA < 213 > human 98677.doc -42- 200533758 < 220 > < 223> Probe 1867-at HG-U95Av2 < 400 > 66 taacacccta tgcccattgt cctgatctga aaattcttgg aaattgttcc atgtgattaa 60 catggaactg cctctactta atcattctga atgattaaat cgtttcattt tctaaatgtg 120 ttataatgtg tttagccctt atcttttgtt 180 actactaata tcttgttgct gtatgtttag atgctttcca atg 193

<210〉 67 <211> 408 <212〉 DNA <213> 人類 <220> <223> Probe 1868—g—at HG-U95Av2 <400〉 67 atttgacctg ctcaaacgta tcttgaagat ggacagaaaa gctgtggaga cccacctgct 60 • caggaaccct caccttgttt cggactatag agtgctgatg gcagagattg gtgaggattt 120 ggataaatct gatgtgtcct cattaatttt cctcatgaag gattacatgg gccgaggcaa 180 gataagcaag gagaagattt cttgggacct tgtggttgag ttggagaaac taaatctggt 240 tgccccagat caactggatt tattagaaaa atgcctaaag aacatccaca gaatagacct 300 gaagacaaaa atccagaagt acaagcagtc tgttcaagga gcagggacaa gttacaggaa 360 tgttctccaa gcagcaatcc aaaagagtct caaggatcct tcaaataa 408 98677.doc -43- 200533758 <210〉 68 <211> 523 <212〉 DNA <213〉人類 <220> <223> Probe 1897_at HG-U95Av2 <400〉 68< 210> 67 < 211 > 408 < 212> DNA < 213 > Human < 220 > < 223 > Probe 1868-g-at HG-U95Av2 < 400> 67 atttgacctg ctcaaacgta tcttgaagat ggacagaaaa gctgtgaga ccc caggaaccct caccttgttt cggactatag agtgctgatg gcagagattg gtgaggattt 120 ggataaatct gatgtgtcct cattaatttt cctcatgaag gattacatgg gccgaggcaa 180 gataagcaag gagaagattt cttgggacct tgtggttgag ttggagaaac taaatctggt 240 tgccccagat caactggatt tattagaaaa atgcctaaag aacatccaca gaatagacct 300 gaagacaaaa atccagaagt acaagcagtc tgttcaagga gcagggacaa gttacaggaa 360 tgttctccaa gcagcaatcc aaaagagtct caaggatcct tcaaataa 408 98677.doc -43- 200533758 < 210〉 68 < 211 > 523 < 212〉 DNA < 213〉 Human < 220 > < 223 > Probe 1897_at HG-U95Av2 < 400> 68

ggaaccacag atttgtgccc attcctaata ttttgttctg caaattaatg tataatttga ggtgaaattc agttataaag tcaaggacga atttgcacag tgatatattt ctatgtgtat gcaagtacaa gtatataata tgtcacctgg cacattcatt ttctcagttg aagaagagaa aatttgaaaa tgtccttatg cttttagagt tgcaacttaa gtatatttgg tagggtgagt gtttccactc aaaatatgtc aacttaaaaa aaaataggcc ctttcataaa aaccaaactg tagcaagatg caaatgcatg gcaaatctgt cggtctccag ttggttatct gaatagtgtc accaattcca ccaagacagt gctgagattg gaaagggcac tcatttggat tgccttactt ctcttgcctt aaatatatcc catatattta atatgtcaaa aagggcttga ggtgaatttc attaaatgga ataatatgat gccactttgc agctaaaata age <210> 69 <211〉 451 <212〉 DNA <213〉人類 <220〉 <223> Probe 1951一at HG-U95Av2 <400〉 69 tcaaggccac aaccatgatg atccgaccag cagatttcta aacatcccag tccacctgag 98677.doc -44- 120 120ggaaccacag atttgtgccc attcctaata ttttgttctg caaattaatg tataatttga agttataaag ggtgaaattc atatgtcaaa aagggcttga ggtgaatttc tcaaggacga atttgcacag tgatatattt ctatgtgtat gcaagtacaa gtatataata tgtcacctgg cacattcatt ttctcagttg aagaagagaa aatttgaaaa tgtccttatg cttttagagt tgcaacttaa gtatatttgg tagggtgagt gtttccactc aaaatatgtc aacttaaaaa aaaataggcc ctttcataaa aaccaaactg tagcaagatg caaatgcatg gcaaatctgt cggtctccag ttggttatct gaatagtgtc accaattcca ccaagacagt gctgagattg gaaagggcac tcatttggat tgccttactt ctcttgcctt aaatatatcc catatattta attaaatgga ataatatgat gccactttgc agctaaaata age < 210 > 69 < 211〉 451 < 212〉 DNA < 213〉 human < 220〉 < 223 > Probe 1951 one at HG-U95Av2 < 400> 69 tcaaggccac aaccatgatg atccgaccag cagatttcta tacc acat .doc -44- 120 120

200533758 gaactgtctc gaactatttt caaagactta agcccagtgc actgaaagtc acggctgcgc actgtgtcct cttccaccac agagggcgtg tgctcggtgc tgacgggacc cacatgctcc agattagagc ctgtaaactt tatcacttaa acttgcatca cttaacggac caaagcaaga ccctaaacat ccataattgt gattagacag aacacctatg caaagatgaa cccgaggctg agaatcagac tgacagttta cagacgctgc tgtcacaacc aagaatgtta tgtgcaagtt tatcagtaaa taactggaaa acagaacact tatgttatac aalacagatc atcttggaac tgcattcttc tgagcactgt ttatacactg t <210> 70 <211> 461 <212〉 DNA <213>人類 <220〉 <223〉 Probe 1968—g_at HG-U95Av2 180 240 300 360 420 451200533758 gaactgtctc gaactatttt caaagactta agcccagtgc actgaaagtc acggctgcgc actgtgtcct cttccaccac agagggcgtg tgctcggtgc tgacgggacc cacatgctcc agattagagc ctgtaaactt tatcacttaa acttgcatca cttaacggac caaagcaaga ccctaaacat ccataattgt gattagacag aacacctatg caaagatgaa cccgaggctg agaatcagac tgacagttta cagacgctgc tgtcacaacc aagaatgtta tgtgcaagtt tatcagtaaa taactggaaa acagaacact tatgttatac aalacagatc atcttggaac tgcattcttc tgagcactgt ttatacactg t < 210 > 70 < 211 > 461 < 212〉 DNA < 213 > human < 220> < 223〉 Probe 1968—g_at HG-U95Av2 180 240 300 360 420 451

<400〉 70 ctatggatta ggccagatcc gccacatttg catcacagag cttcctgagc tgctgatgaa ggacatgaag agccggtccc agtgaaaaac aacattgtaa tattgcttct caccacccag agcacacgga caggctgata aacctgtcat aagctctcat acttgctggg atggagattt agaagccaaa gctatgttat ctacacagta gaaagttgca gtctgaactg agcctgcacc ggtcaactat gaaagagctg tttatctttt tgtccccatg gtgaagatgc aagataatga aagtcaggcc ttgcataaga gatatctttg gaaaacaatg ctagaaagga taaaacccac ctcacctggg ccatttacat atagggatag gattgaaccc gtgactacat aagaggtttc 60 120 180 240 300 360 420 98677.doc -45 - 200533758 taaatattcc gacatccaga gatcactcta tgatcgtcca g <210> 71 <211> 325 <212〉 DNA <213〉人類 <220> <223> Probe 1987—at HG-U95Av2≪ 400> 70 ctatggatta ggccagatcc gccacatttg catcacagag cttcctgagc tgctgatgaa ggacatgaag agccggtccc agtgaaaaac aacattgtaa tattgcttct caccacccag agcacacgga caggctgata aacctgtcat aagctctcat acttgctggg atggagattt agaagccaaa gctatgttat ctacacagta gaaagttgca gtctgaactg agcctgcacc ggtcaactat gaaagagctg tttatctttt tgtccccatg gtgaagatgc aagataatga aagtcaggcc ttgcataaga gatatctttg gaaaacaatg ctagaaagga taaaacccac ctcacctggg ccatttacat atagggatag gattgaaccc gtgactacat aagaggtttc 60 120 180 240 300 360 420 98677.doc -45-200533758 taaatattcc gacatccaga gatcactcta tgatcgtcca g < 210 > 71 < 211 > 325 < 212〉 DNA < 213> human < 220 > < 223 > Probe 1987-at HG- U95Av2

<400〉 71 agaggaacct gagtcatgct caggcccaag ccctgttggc aggcagacca ctgctttctg gccttccgtg actatctgaa aaaaatcgtg aatggctaga gctactcttc acttgctgaa cattttcaaa aagaattgac acttgctgaa catttctttt caattcagaa cttctgatgg attaaattgc cttcttcctc gaaaaccctg ggacccttcc agatgggact aactggggaa agtggacaag ttacaaacaa agaaactcaa aggaaagtca ttggcactga tctctaagat gctatcacat gtgattggtg gttga <210〉 72 <211> 323 <212> DNA <213>人類 <220〉 <223> Probe 2002—s_at HG-U95Av2 <400> 72 ctacagatac cacaacctgg atcaggtcca agcaaaacgt ccagagtgct acaaaatgtt 98677.doc -40- 120 120≪ 400> 71 agaggaacct gagtcatgct caggcccaag ccctgttggc aggcagacca ctgctttctg gccttccgtg actatctgaa aaaaatcgtg aatggctaga gctactcttc acttgctgaa cattttcaaa aagaattgac acttgctgaa catttctttt caattcagaa cttctgatgg attaaattgc cttcttcctc gaaaaccctg ggacccttcc agatgggact aactggggaa agtggacaag ttacaaacaa agaaactcaa aggaaagtca ttggcactga tctctaagat gctatcacat gtgattggtg gttga < 210> 72 < 211 > 323 < 212 > DNA < 213 > Human < 220> < 223 > Probe 2002—s_at HG-U95Av2 < 400 > 72 ctacagatac cacaacctgg atcaggtcca agcaaaacgt ccagagtgct acaaaatgtt 98677.doc -40- 120 120

200533758 gcgttctcag tccaaaaaga agtggaaaag aatctgaagt catgcttgga caatgttaat gttgtgtccg tagacactgc cagaacacta ttcaaccaag tgatggaaaa ggagtttgaa gacggcatca ttaactgggg aagaattgta accatatttg catttgaagg tattctcatc aagaaacttc tacgacagca aattgccccg gatgtggata cctataagga gatttcatat tttgttgcgg agttcataat gaa <210〉 73 <211〉 436 <212〉 DNA <213>人類 <220〉 <223> Probe 2014—s_at HG-U95Av2 <400〉 73 ccatccttcg atttccctat gattcatggg gaactccatt tcagcagctc aaacaggtgg tagaggagcc atcgccacaa ctcccagcag acaagttctc tgcagagttt gttgacttta cctcacagtg cttaaagaag aattccaaag aacggcctac atacccagag ctaatgcaac atccattttt caccctacat gaatccaaag gaacagatgt ggcatctttt gtaaaactga ttcttggaga ctaaaaagca gtggacttaa tcggttgacc ctactgtgga ttggtgggtt tcggggtgaa gcaagttcac tacagcatca atagaaagtc atctttgaga taatttaacc ctgcctctca gagggttttc tctcccaatt ttctttttac tccccctctt aagggggcct tggaatctat agtata <210〉 74 180 240 300 323 60 120 180 240 300 360 420 98677.doc -47- 436200533758 gcgttctcag tccaaaaaga agtggaaaag aatctgaagt catgcttgga caatgttaat gttgtgtccg tagacactgc cagaacacta ttcaaccaag tgatggaaaa ggagtttgaa gacggcatca ttaactgggg aagaattgta accatatttg catttgaagg tattctcatc aagaaacttc tacgacagca aattgccccg gatgtggata cctataagga gatttcatat tttgttgcgg agttcataat gaa < 210> 73 < 211> 436 < 212> DNA < 213 > human < 220> < 223 > Probe 2014-s_at HG-U95Av2 < 400> 73 ccatccttcg atttccctat gattcatggg gaactccatt tcagcagctc aaacaggtgg tagaggagcc atcgccacaa ctcccagcag acaagttctc tgcagagttt gttgacttta cctcacagtg cttaaagaag aattccaaag aacggcctac atacccagag ctaatgcaac atccattttt caccctacat gaatccaaag gaacagatgt ggcatctttt gtaaaactga ttcttggaga ctaaaaagca gtggacttaa tcggttgacc ctactgtgga ttggtgggtt tcggggtgaa gcaagttcac tacagcatca atagaaagtc atctttgaga taatttaacc ctgcctctca gagggttttc tctcccaatt ttctttttac tccccctctt aagggggcct tggaatctat agtata < 210〉 74 180 240 300 323 60 120 180 240 300 300 360 420 98677.doc -47- 436-436

200533758 <211> 595 <212〉 DNA <213>人類 <220> <223> Probe 2018—at HG-U95Av2 <400> 74 tcagcttgag tgctgtttac acttgcaaaa gagatccctg cccacatcag gtggactgtt tcctctctcg ccccacggag aaaaccatct tcatcatctt catgctggtg gtgtccttgg tgtccctggc cttgaatatc attgaactct tctatgtttt cttcaagggc gttaaggatc gggttaaggg aaagagcgac ccttaccatg cgaccagtgg tgcgctgagc cctgccaaag actgtgggtc tcaaaaatat gcttatttca atggctgctc ctcaccaacc gctcccctct cgcctatgtc tcctcctggg tacaagctgg ttactggcga cagaaacaat tcttcttgcc gcaattacaa caagcaagca agtgagcaaa actgggctaa ttacagtgca gaacaaaatc gaatggggca ggcgggaagc accatctcta actcccatgc acagcctttt gatttccccg atgataacca gaattctaaa aaactagctg ctggacatga attacagcca ctagccattg tggaccagcg accttcaagc agagccagca gtcgtgccag cagcagacct cggcc <210> 75 <211> 550 <212> DNA <213>人類 <220> <223〉 Probe 2024_s—at HG-U95Av2 <400〉 75 60 120 180 240 300 360 420 480 540 595 98677.doc -48- 60 60200533758 < 211 > 595 < 212〉 DNA < 213> attgaactct tctatgtttt cttcaagggc gttaaggatc gggttaaggg aaagagcgac ccttaccatg cgaccagtgg tgcgctgagc cctgccaaag actgtgggtc tcaaaaatat gcttatttca atggctgctc ctcaccaacc gctcccctct cgcctatgtc tcctcctggg tacaagctgg ttactggcga cagaaacaat tcttcttgcc gcaattacaa caagcaagca agtgagcaaa actgggctaa ttacagtgca gaacaaaatc gaatggggca ggcgggaagc accatctcta actcccatgc acagcctttt gatttccccg atgataacca gaattctaaa aaactagctg ctggacatga attacagcca ctagccattg tggaccagcg accttcaagc agagccagca gtcgtgccag cagcagacct cggcc < 210 > 75 < 211 > 550 < 212 > DNA < 213 > human < 220 > < 223〉 Probe 2024_s—at HG-U95Av2 < 400> 75 60 120 180 240 300 360 420 480 540 595 98677.doc- 48- 60 60

200533758 agtttgctgg atttcctgaa gagcgatgaa ggtggcaaag tgctgcttcc aaagctcatt gacttttctg ctcagattgc agagggaatg gcatacatcg agcggaagaa ctacattcac cgggacctgc gagcagctaa tgttctggtc tccgagtcac taatgtgcaa aattgcagat tttggccttg ctagagtaat tgaagataat gagtacacag caagggaagg tgctaagttc cctattaagt ggacggctcc agaagcaatc aactttggat gtttcactat taagtctgat gtgtggtcct ttggaatcct cctatacgaa attgtcacct atgggaaaat tccctaccca gggagaacta atgccgacgt gatgaccgcc ctgtcccagg gctacaggat gccccgtgtg gagaactgcc cagatgagct ctatgacatt atgaaaatgt gctggaaaga aaaggcagaa gagagaccaa cgtttgacta cttacagagc gtcctggatg atttctacac agccacggaa gggcaatacc <210〉 76 <211> 232 <212〉 DNA <213〉人類 <220> <223> Probe 2036_s_at HG-U95Av2 120 180 240 300 360 420 480 540 550 <400〉 76 gagctgggac gcataaaatt tgtaaaaaca gttcagttcc acttaacaga ttctactctt gcattgcttt acttggaggc tgcaatgtgc tttgtttttt gtaaattagg cttcatcctc tactgattgt gtgttttgtt gcccaattaa gggtgtgcta ttcattgcga ctttaaagtc taatcagcaa tggatggctt atctttttta aggtccaatt gaatttgatc ct 60 120 180 232 98677.doc -49-200533758 agtttgctgg atttcctgaa gagcgatgaa ggtggcaaag tgctgcttcc aaagctcatt gacttttctg ctcagattgc agagggaatg gcatacatcg agcggaagaa ctacattcac cgggacctgc gagcagctaa tgttctggtc tccgagtcac taatgtgcaa aattgcagat tttggccttg ctagagtaat tgaagataat gagtacacag caagggaagg tgctaagttc cctattaagt ggacggctcc agaagcaatc aactttggat gtttcactat taagtctgat gtgtggtcct ttggaatcct cctatacgaa attgtcacct atgggaaaat tccctaccca gggagaacta atgccgacgt gatgaccgcc ctgtcccagg gctacaggat gccccgtgtg gagaactgcc cagatgagct ctatgacatt atgaaaatgt gctggaaaga aaaggcagaa gagagaccaa cgtttgacta cttacagagc gtcctggatg atttctacac agccacggaa gggcaatacc < 210〉 76 < 211 > 232 < 212〉 DNA < 213〉 Human < 220 > < 223 > Probe 2036_s_at HG-U95Av2 120 180 240 300 360 360 360 400〉 76 gagctgggac gcataaaatt tgtaaaaaca gttcagttcc acttaacaga ttctactctt gcattgcttt acttggaggc tgcaatgtgc tttgtttttt gtaaattagg cttcatcctc tactgattgt gtgttttttgtt gcccaattaa gggggtgcct ctcat ctcat tttttta aggtccaatt gaatttgatc ct 60 120 180 232 98677.doc -49-

200533758 <210〉 77 <211> 602 <212> DNA <213>人類 <220> <223〉 Probe 2049_s_at HG-U95Av2 <400〉 77 aagccctgga cgatctgcac aagatgaacc acgtgacacc ccccaacgtg tccctgggcg ctaccggggg gcccccggct gggcccgggg gcgtctacgc cggcccggag ccacctcccg tttacaccaa cctcagcagc tactccccag cctctgcgtc ctcgggaggc gccggggctg ccgtcgggac cgggagctcg tacccgacga ccaccatcag ctacctccca cacgcgccgc ccttcgccgg tggccacccg gcgcagctgg gcttgggccg cggcgcctcc accttcaagg aggaaccgca gaccgtgccg gaggcgcgca gccgggacgc cacgccgccg gtgtccccca tcaacatgga agaccaagag cgcatcaaag tggagcgcaa gcggctgcgg aaccggctgg cggccaccaa gtgccggaag cggaagctgg agcgcatcgc gcgcctggag gacaaggtga agacgctcaa ggccgagaac gcggggctgt cgagtaccgc cggcctcctc cgggagcagg tggcccagct caaacagaag gtcatgaccc acgtcagcaa cggctgtcag ctgctgcttg gg <210> 78 <211> 262 <212> DNA <213〉人類 60 120 180 240 300 360 420 480 540 600 602 98677.doc -5〇 - 200533758 <220> <223〉 Probe 204_at HG-U95Av2 <220> <221> misc_feature <222〉 （176)..(177) <223> n 為 a，g，c 或 t200533758 < 210> 77 < 211 > 602 < 212 > DNA < 213 > human < 220 > < 223〉 Probe 2049_s_at HG-U95Av2 < 400> 77 aagccctgga cgatctggggg aagatgaacc acgtgacacc cccccgggggcccggggcccgccggg ccacctcccg tttacaccaa cctcagcagc tactccccag cctctgcgtc ctcgggaggc gccggggctg ccgtcgggac cgggagctcg tacccgacga ccaccatcag ctacctccca cacgcgccgc ccttcgccgg tggccacccg gcgcagctgg gcttgggccg cggcgcctcc accttcaagg aggaaccgca gaccgtgccg gaggcgcgca gccgggacgc cacgccgccg gtgtccccca tcaacatgga agaccaagag cgcatcaaag tggagcgcaa gcggctgcgg aaccggctgg cggccaccaa gtgccggaag cggaagctgg agcgcatcgc gcgcctggag gacaaggtga agacgctcaa ggccgagaac gcggggctgt cgagtaccgc cggcctcctc cgggagcagg tggcccagct caaacagaag gtcatgaccc acgtcagcaa cggctgtcag ctgctgcttg gg < 210 > 78 < 211 > 262 < 212 > DNA < 213〉 Human 60 120 180 240 300 360 420 480 540 600 602 98677.doc -5〇- 200533758 < 220 > < 223> Probe 204_at HG -U95Av2 < 220 > < 221 > misc_feature < 222> (176) .. (177) < 223 > n is a, g, c or t

<400> 78 agatcttaac tcatccaccc aaagaataat agagaacagt ccaggtgtgg cagtttctat ctccccatct caaaaagaag tgtccaggat aacagcccat cccttacctg ggaccataat acattatccg gctggctggt gc cttttctctt agggacacca gttaagagtc ggaacaacct ctcttctcct aaacaaaccc tgtgctggtt gctggcccga gctccgttcc aaattggtaa gccacnnaag aacaaggctg 60 120 180 240 262 <210〉 79 <211〉 351 <212> DNA <213>人類≪ 400 > 78 agatcttaac tcatccaccc aaagaataat agagaacagt ccaggtgtgg cagtttctat ctccccatct caaaaagaag tgtccaggat aacagcccat cccttacctg ggaccataat acattatccg gctggctggt gc cttttctctt agggacacca gttaagagtc ggaacaacct ctcttctcct aaacaaaccc tgtgctggtt gctggcccga gctccgttcc aaattggtaa gccacnnaag aacaaggctg 60 120 180 240 262 < 210> 79 < 211> 351 < 212 > DNA < 213 > human

<220〉 <223〉 Probe 205—g—at HG-U95Av2 <400〉 79 acagcccatg ctgactgggg acatacactt gcatctttgt tgaaagcaga agaagacaga 60 ccctttcccc accttcctta cctcctcttc ccccattaag gcagctcatc caagcttgta 120 tttaactgaa taaatgagta gacattgtgg acctcacaag attatttaat tcttaagatg 180 tgtagacctt gatggtaggt gtgacatgtt agtttttctt acttgcattt atttaagaca 240 98677.doc -51 - 300 200533758 cactgttaca gagatactgt tgtcaccttc tggggcacgg tctttgggga gaggggagtg catttagact tatgtggaac ctgtacaaat tgtgatgtgg ctacatagaa a <210〉 80 <211> 560 <212> DNA <213>人類 <220> <223> Probe 2073—s—at HG-U95Av2 <400> 80 ccacagctgt gctggaccgt gagtccccat ttgtcgacaa cagcgtgtac actgctctct tcctggcaat tgacagtggc aaccctcccg ctacgggcac tgggactttg ctgataaccc tggaggacgt gaatgacaat gccccgttca tttaccccac agtagctgaa gtctgtgatg atgccaaaaa cctcagtgta gtcattttgg gagcatcaga taaggatctt cacccgaata cagatccttt caaatttgaa atccacaaac aagctgttcc tgataaagtc tggaagatct ccaagatcaa caatacacac gccctggtaa gccttcttca aaatctgaac aaagcaaact acaacctgcc catcatggtg acagattcag ggaaaccacc catgacgaat atcacagatc tcagggtaca agtgtgctcc tgcaggaatt ccaaagtgga ctgcaacgcg gcgggggccc tgcgcttcag cctgccctca gtcctgctcc tcagcctctt cagcttagct tgtctgtgag aactcctgac gtctgaagctatttaagaca 400> 79 acagcccatg ctgactgggg acatacactt gcatctttgt tgaaagcaga agaagacaga 60 ccctttcccc accttcctta cctcctcttc ccccattaag gcagctcatc 120 tttaactgaa caagcttgta taaatgagta gacattgtgg acctcacaag attatttaat tcttaagatg 180 tgtagacctt gatggtaggt gtgacatgtt agtttttctt acttgcattt 240; < 220> < 223> Probe 205-g-at HG-U95Av2 & lt 98677.doc -51-300 200533758 cactgttaca gagatactgt tgtcaccttc tggggcacgg tctttgggga gaggggagtg catttagact tatgtggaac ctgtacaaat tgtgatgtgg ctacatagaa a < 210> 80 < 211 > 560 < 212 > DNA > DNA < 212 > DNA -s-at HG-U95Av2 < 400 > 80 ccacagctgt gctggaccgt gagtccccat ttgtcgacaa cagcgtgtac actgctctct tcctggcaat tgacagtggc aaccctcccg ctacgggcac tgggactttg ctgataaccc tggaggacgt gaatgacaat gccccgttca tttaccccac agtagctgaa gtctgtgatg atgccaaaaa cctcagtgta gtcattttgg gagcatcaga taaggatctt cacccgaata cagatccttt caaatttgaa atccacaaac aagctgttcc tgataaagtc tggaagatct ccaagatcaa caatacacac gccctggtaa gccttct tca aaatctgaac aaagcaaact acaacctgcc catcatggtg acagattcag ggaaaccacc catgacgaat atcacagatc tcagggtaca agtgtgctcc tgcaggaatt ccaaagtgga ctgcaacggagt gctgctgctctctgctctctct

<210> 81 <211〉 268 <212〉 DNA 351< 210 > 81 < 211〉 268 < 212> DNA 351

60 120 180 240 300 360 420 480 540 98677.doc -52- 560 200533758 <213> 人類 <220〉 <223> Probe 215_g—at HG-U95Av2 <400〉 8160 120 180 240 300 360 420 480 540 98677.doc -52- 560 200533758 < 213 > Human < 220〉 < 223 > Probe 215_g-at HG-U95Av2 < 400〉 81

ggcgcccgtg ggactctaca cggcccatgt gggctacagc atgtaccacc tgacatagag ggtcccaggt ccccacctgt gggccagccg attcctccag ccctggtgct gtacccccga cgtgctcccc tgctcggcac cgccagccgc cttcccttta accctcacac tgctccagtt tcacctcttt gctccctgag ttcactctcc gaagtctgat ccctgccaaa aagtggctgg aagagtccct tagtactctt ctagcatt <210〉 82 <211> 481 <212> DNA <213>人類 <220〉 <223〉 Probe 231—at HG-U95Av2ggcgcccgtg ggactctaca cggcccatgt gggctacagc atgtaccacc tgacatagag ggtcccaggt ccccacctgt gggccagccg attcctccag ccctggtgct gtacccccga cgtgctcccc tgctcggcac cgccagccgc cttcccttta accctcacac tgctccagtt tcacctcttt gctccctgag ttcactctcc gaagtctgat ccctgccaaa aagtggctgg aagagtccct tagtactctt ctagcatt < 210> 82 < 211 > 481 < 212 > DNA < 213 > human < 220 〉 ≪ 223〉 Probe 231—at HG-U95Av2

<400> 82 acctcaccat cggggcctcc aggagactga aagcaaggct actgctccat tatcaaaaaa tgtgaagcac aacccattta ggcttagaga gggtaatgtg ttataacccc agactcagcc ctactatgtg atcaccatgg gaggaggcag aaggcccaag agcctgacct aagacaagga ctgggtgcct gaaactgttg ccccctccac agcagagtct gagactgtcg ggtagagagg cccacacttg tgggcgctgc accagtggcc gggcctctga cagaggctgt ggactggggg ctggggctca ttccaggata tcgtggttat ctctgagtcc ctggggcctt actgggagtc 98677.doc -53- 200533758 agagccctgg ctgggttcag gtcccacgtc tggccagcga ctgccttctc ctctctgggc ctttgtttcc ttgttggtca gaggagtgat tgaacctgct catctccaag gatcctctcc a <210〉 83 <211〉 445 <212〉 DNA <213> 人類≪ 400 > 82 acctcaccat cggggcctcc aggagactga aagcaaggct actgctccat tatcaaaaaa tgtgaagcac aacccattta ggcttagaga gggtaatgtg ttataacccc agactcagcc ctactatgtg atcaccatgg gaggaggcag aaggcccaag agcctgacct aagacaagga ctgggtgcct gaaactgttg ccccctccac agcagagtct gagactgtcg ggtagagagg cccacacttg tgggcgctgc accagtggcc gggcctctga cagaggctgt ggactggggg ctggggctca ttccaggata tcgtggttat ctctgagtcc ctggggcctt actgggagtc 98677.doc -53- 200533758 agagccctgg ctgggttcag gtcccacgtc tggccagcga ctgccttctc ctctctgggc ctttgtttcc ttgttggtca gaggagtgat tgaacctgct catctccaag gatcctctcc a < 210〉 83 < 211〉 445 < 212〉 DNA < 213 > human

<220> <223> Probe 257_at HG-U95Av2< 220 > < 223 > Probe 257_at HG-U95Av2

<400〉 83 tagcaacagt gaatttgctt tggagattga aatatagttt aaaaatatgg tttatcatga gaaatactac ttatgatctg catttctgaa ttgtgccatc aagatgctgt tgtataatag agaagagcaa ttaaatatca catatttgtg attcagtttt aatatgttgg tattcctttt aatttagaaa catagatttt tttgaaagcc aaaaattgcc atttattgag aagaa atagaaagtc atggcatcta ttaacatgat ccttcaaaaa tactttctga ctatgaaaac aataaaaatc actctttggc tcttgaaagt atcttaaatt atgaacattt agaaaatggt tttaaatctc cattttgaaa aaaagtgtta aatcttgtat acctttatga atatatctac gggatttttt taaaacattt tgtaaaattt <210> 84 <211〉 614 <212〉 DNA <213〉人類 98677.doc -54- 60200533758 <220〉 <223〉 Probe 265—s_at HG-U95Av2 <400〉 84 atgtctaata gaatgcctgt aatctccagt gttattccct gtgagcaagc tttcagttga atttgttttc atttatgttt tcactggcaa ttctgtatgt atttataagc tgaaaaattc tagggtgctc agatttaaca tcagtcagta tggaagagag attccaaagg attgccaaag≪ 400> 83 tagcaacagt gaatttgctt tggagattga aatatagttt aaaaatatgg tttatcatga gaaatactac ttatgatctg catttctgaa ttgtgccatc aagatgctgt tgtataatag agaagagcaa ttaaatatca catatttgtg attcagtttt aatatgttgg tattcctttt aatttagaaa catagatttt tttgaaagcc aaaaattgcc atttattgag aagaa atagaaagtc atggcatcta ttaacatgat ccttcaaaaa tactttctga ctatgaaaac aataaaaatc actctttggc tcttgaaagt atcttaaatt atgaacattt agaaaatggt tttaaatctc cattttgaaa aaaagtgtta aatcttgtat acctttatga atatatctac gggatttttt taaaacattt tgtaaaattt < 210 > 84 < 211〉 614 < 212〉 DNA < 213〉 human 98677.doc -54- 60200533758 < 220〉 < 223〉 Probe 265—s_at HG-U95Av2 < 400> 84 atgtctaata gaatgcctgt aatctccagt gttattccct gtgagcaagc tttcagttga atttgttttttc atttatgttt tcactggcaa ttctgtatgt atttataagc tgaaaaattc tagggtgctc agatttaaca tcagtcagta tggaagagag attccaaagg attgccaaag

ctgctctagc cttgaggagt gtgagaatca aaactctcct acacttccat taacttagca tgtgttgaaa aaaaaagttt cagagaagtt ctggctgaac actggcaacg acaaagccaa cagtcaaaac agagatgtga taaggatcag aacagcagag gttcttttaa aggggcagaa aaactctggg aaataagaga gaacaactac tgtgatcagg ctatgtatgg aatacagtgt tattttcttt gaaattgttt aagtgttgta aatatttatg taaactgcat tagaaattag ctgtgtgaaa taccagtgtg gtttgtgttt gagttttatt gagaatttta aattataact taaaatattt tataattttt aaagtatata tttatttaag cttatgtcag acctatttga cataacacta taaa 120 180 240 300 360 420 480 540 600 614 <210〉 85 <211> 508 <212〉 DNA <213>人類 <220〉 <223> Probe 286—at HG-U95Av2 <400> 85 tcgccaggca ggagtttctc tcggtgacta ctatcgctgt catgtctggt cgtggcaagc 986^7.doc -55- 60 120 120ctgctctagc cttgaggagt gtgagaatca aaactctcct acacttccat taacttagca tgtgttgaaa aaaaaagttt cagagaagtt ctggctgaac actggcaacg acaaagccaa cagtcaaaac agagatgtga taaggatcag aacagcagag gttcttttaa aggggcagaa aaactctggg aaataagaga gaacaactac tgtgatcagg ctatgtatgg aatacagtgt tattttcttt gaaattgttt aagtgttgta aatatttatg taaactgcat tagaaattag ctgtgtgaaa taccagtgtg gtttgtgttt gagttttatt gagaatttta aattataact taaaatattt tataattttt aaagtatata tttatttaag cttatgtcag acctatttga cataacacta taaa 120 180 240 300 360 420 480 540 600 614 < 210〉 85 < 211 > 508 < 212> DNA < 213 > human < 220> < 223 > Probe 286-at HG-U95Av2 < 400 > 85 tcgccaggca ggagtttctc tcggtgacta ctatcgctgt cat 986 ^ 7.doc -55- 60 120 120

200533758 aaggaggcaa ggcccgcgcc aaggccaagt cgcgctcgtc ccgcgctggc cttcagttcc cggtagggcg agtgcatcgc ttgctgcgca aaggcaacta cgcggagcga gtgggggccg gcgcgcccgt ctacatggct gcggtcctcg agtatctgac cgccgagatc ctggagctgg cgggcaacgc ggctcgggac aacaagaaga cgcgcatcat ccctcgtcac ctccagctgg ccatccgcaa cgacgaggaa ctgaacaagc tgctgggcaa agtcaccatc gcccagggcg gcgtcttgcc taacatccag gccgtactgc tccctaagaa gacggagagt caccacaagg caaagggcaa gtgaggctga cgtccggccc aagtgggccc agcccggccc gcgtctcgaa ggggcacctg tgaactcaaa aggctctt <210〉 86 <211> 415 <212〉 DNA <213>人類 <220〉 <223> Probe 287^at HG-U95Av2 180 240 300 360 420 480 508200533758 aaggaggcaa ggcccgcgcc aaggccaagt cgcgctcgtc ccgcgctggc cttcagttcc cggtagggcg agtgcatcgc ttgctgcgca aaggcaacta cgcggagcga gtgggggccg gcgcgcccgt ctacatggct gcggtcctcg agtatctgac cgccgagatc ctggagctgg cgggcaacgc ggctcgggac aacaagaaga cgcgcatcat ccctcgtcac ctccagctgg ccatccgcaa cgacgaggaa ctgaacaagc tgctgggcaa agtcaccatc gcccagggcg gcgtcttgcc taacatccag gccgtactgc tccctaagaa gacggagagt caccacaagg caaagggcaa gtgaggctga cgtccggccc aagtgggccc agcccggccc gcgtctcgaa ggggcacctg tgaactcaaa aggctctt < 210> 86 < 211 > 415 < 212〉 DNA < 213 > human < 220> < 223 > Probe 287 ^ at HG-U95Av2 180 240 300 360 420 480 508

<400> 86 gttaacacaa agtcacagga cttaggtcag ttgtggttga taccaggttt aaatctggcc aatccatggg agaaagcaga gagttgtgtc aaccacagtc agcattattg cagggtgttt cagcatgatg aagttcaact taggctggaa agtggagaga gatgtcaaaa gcagctgtga gcaggtcctc tccaaagggt gagccaaaga tgtttggaac gcattttttt gaagtcactc tgttgcaaac taggactctc aatattccat acagtcagtg tgtcatgtag acactggcca tcagttccaa cactcaatgt tttcctttcc gagctggtgg ctgttttaag caaggacgct 60 120 180 240 300 360 98677.doc -56 - 200533758 ggctactgtc tattaaaatt ctgatgtttc tgtgaaattc tcagagtgtt taatt 415 <210〉 87 <211〉 431 <212〉 DNA <213>人類 <220〉 <223> Probe 31472_s_at HG-U95Av2 <220〉 <221> misc_feature 籲 <222〉 （75)..(95) <223> n 為 a，g，c 或 t <400〉 87 gacaagtttt ggtggcacgc agcctgggga ctctgcctcg tgccgctgag cctggcgcag 60 atcgatttga atatnnnnnn nnnnnnnnnn nnnnnattcc acgtggagaa aaatggtcgc 120 tacagcatct ctcggacgga ggccgctgac ctctgcaagg ctttcaatag caccttgccc 180 acaatggccc agatggagaa agctctgagc atcggatttg agacctgcag tttgcattgc 240≪ 400 > 86 gttaacacaa agtcacagga cttaggtcag ttgtggttga taccaggttt aaatctggcc aatccatggg agaaagcaga gagttgtgtc aaccacagtc agcattattg cagggtgttt cagcatgatg aagttcaact taggctggaa agtggagaga gatgtcaaaa gcagctgtga gcaggtcctc tccaaagggt gagccaaaga tgtttggaac gcattttttt gaagtcactc tgttgcaaac taggactctc aatattccat acagtcagtg tgtcatgtag acactggcca tcagttccaa cactcaatgt tttcctttcc gagctggtgg ctgttttaag caaggacgct 60 120 180 240 300 360 98677.doc -56-200533758 ggctactgtc tattaaaatt ctgatgtttc tgtgaaattc tcagagtgtt taatt 415 < 210〉 87 < 211〉 431 < 212〉 DNA < 213 > human < 220〉 < 223 > Probe 31472_s_at HG-U95Av2 < 221 > misc_feature &< 222〉 (75) .. (95) < 223 > n is a, g, c or t < 400> 87 gacaagtttt ggtggcacgc agcctgggga ctctgcctcgggn atcgattnnn actn nn tatt ggccgctgac ctctgcaagg ctttcaatag caccttgccc 180 acaatggccc agatggagaa agctctgagc atcggattt g agacctgcag tttgcattgc 240

agtcaacagt cgaagaaggt gtgggcagaa gaaaaagcta gtgatcaaca gtggcaatgg 300 agctgtggag gacagaaagc caagtggact caacggagag gccagcaagt ctcaggaaat 360 ggtgcatttg gtgaacaagg agtcgtcaga aactccagac cagtttatga cagctgatga 420 gacaaggaac c 431agtcaacagt cgaagaaggt gtgggcagaa gaaaaagcta gtgatcaaca gtggcaatgg 300 agctgtggag gacagaaagc caagtggact caacggagag gccagcaagt ctcaggaaat 360 ggtgcatttg gtgaacaagg agtcgtcaga aactga cacggccaggt

<210> 88 <211> 576 <212〉 DNA 9S677.doc -57- 200533758 <213> 人類 <220> <223> Probe 31540_at HG-U95Av2 <220〉 <221〉 misc_feature <222〉 （44)..(58) <223> n 為 a，g，c 或 t <220〉 <221> misc_feature • <222> (256)..(529) <223〉n 為 a，g，c 或 t< 210 > 88 < 211 > 576 < 212〉 DNA 9S677.doc -57- 200533758 < 213 > Human < 220 > < 223 > Probe 31540_at HG-U95Av2 < 220> < 221〉 misc_feature < 222〉 (44) .. (58) < 223 > n is a, g, c or t < 220〉 < 221 > misc_feature • < 222 > (256) .. (529) < 223> n is a, g, c or t

<400〉 88 atgagaccag tacaaactac gaagaaggag gatgtgaact aagaagcaag gaaatatgag tacataatac ccaggattcc ttaaaaatgc accacnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gccaaaataa tgcaccactt tcaagaggaa gatggctgta gtgaaatgga agtcaatagg tcatccgcta tcacagcttt cccaacacac gttcttttct nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttaacagaac agacag gctnnnnnnn nnnnnnnnaa gctgttggga ctttcttgaa caaaagcaag aacaccatcc aaatgccaat gagttggcct nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt gccaggcccg 60 120 180 240 300 360 420 480 540 9867”.doc -58- 576 200533758 <210〉 89 <211> 126 <212> DNA <213>人類 <220〉 <223> Probe 31622—f—at HG-U95Av2 <400〉 89 gtgtctcctg agaagagctg gcaaag cacctgcgct ggttcctgca agtgcaaaga gtgcaaatgc acctcctgca 60 ctgctcctgc tgccccgtgg gctgtagcaa gtgtgcccag ggctgtgttt 120 126ctttcttgaa caaaagcaag 400> 88 atgagaccag tacaaactac gaagaaggag gatgtgaact aagaagcaag gaaatatgag tacataatac ccaggattcc ttaaaaatgc accacnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gccaaaataa tgcaccactt tcaagaggaa gatggctgta gtgaaatgga agtcaatagg tcatccgcta tcacagcttt cccaacacac gttcttttct nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttaacagaac agacag gctnnnnnnn nnnnnnnnaa gctgttggga nnnnnnnnnn; & lt aacaccatcc aaatgccaat gagttggcct nnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnt gccaggccc &&;2005;33;doc;33;doc; doc Human < 220〉 < 223 > Probe 31622-f-at HG-U95Av2 < 400> 89 gtgtctcctg agaagagctg gcaaag cacctgcgct ggttcctgca agtgcaaaga gtgcaaatgc acctcctgca 60 ctgctcccatggt ggtgcc tgcc

<210〉 90 <211> 278 <212〉 DNA <213> 人類 <220> <223> Probe 31697_s_at HG-U95Av2 <220〉 <221> mi sc一 feature <222〉 (29)· .(51) <223> n為 a，g，c 或 t <220〉 <221> misc^feature <222〉 (107)..(215) <223> n 為 a，g，c 或 t <400〉 90 98677.doc -59- 200533758 caaactggcc actgacaaaa atgaccccnn nnnnnnnnnn nnnnnnnnnn nacattacct gaatgagcag gtgaaagcca tcaaagaatt gggtgaacgt gaccaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnagctg tggggtgact tccctggtca ccaaggcagt gcatgcatgt tggggtttcc tttacctt <210> 91 <211> 498 <212〉 DNA <213> 人類< 210> 90 < 211 > 278 < 212> DNA < 213 > human < 220 > < 223 > Probe 31697_s_at HG-U95Av2 < 220> < 221 > mi sc-feature < 222> ( 29).. (51) < 223 > n is a, g, c or t < 220〉 < 221 > misc ^ feature < 222〉 (107) .. (215) < 223 > n is a , g, c or t < 400> 90 98677.doc -59- 200533758 caaactggcc actgacaaaa atgaccccnn nnnnnnnnnn nnnnnnnnnn nacattacct gaatgagcag gtgaaagcca tcaaagaatt gggtgaacgt gaccaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnagctg tggggtgact tccctggtca ccaaggcagt gcatgcatgt tggggtttcc tttacctt < 210 > 91 < 211 > 498 < 212〉 DNA < 213 > human

<220〉 <223〉 Probe 31803—at HG-U95Av2 <220〉 <221> misc_feature <222〉 （67)·.(67) <223〉n 為 a，g，c 或 t <220〉 <221〉 <222> <223> misc_feature (302)..(317) n 為 a，g，c 或 t <220> <221> misc一feature <222〉 （392)..(443) <223> n 為 a，g，c 或 t <400〉 91 aagtgggctg tggtgcccat ttgcagtgac tgtgaagtga ctccaggacg gacctgcggg 98677.doc -60- 200533758 ggcaccnaga ggtcctaagc cccaggactg agggtcgtgc atcaccactc gggtgtcccg ggaggtgccc tgggcccggg gacctcacag gcaggacggc gacactaatg cagggagagg gagtctggcc ccagcttttc ctatcagagg cgattttcct tcaccagggg atgggcagga aagaggcagg ggccccagaa gcttctgtcc ctcatgcctg agggcacggg ggacacttgg annnnnnnnn nnnnnnngtg cgtccaaggc catgctctct gcgggtcagt gcctgagtct cgcctccctg ctggtccctg aagccccctc annnnnnnnn nnnnnnnnnn nnnnnnnnnn< 220〉 < 223〉 Probe 31803-at HG-U95Av2 < 220〉 < 221 > misc_feature < 222〉 (67) ·. (67) < 223> n is a, g, c or t < 220> < 221> < 222 > < 223 > misc_feature (302) .. (317) n is a, g, c or t < 220 > < 221 > misc-feature < 222〉 (392 ) .. (443) < 223 > n is a, g, c or t < 400> 91 aagtgggctg tggtgcccat ttgcagtgac tgtgaagtga ctccaggacg gacctgcggg 98677.doc -60- 200533758 ggcaccnaga ggtcctaagc cccaggactg agggtcgtgc atcaccactc gggtgtcccg ggaggtgccc tgggcccggg gacctcacag gcaggacggc gacactaatg cagggagagg gagtctggcc ccagcttttc ctatcagagg cgattttcct tcaccagggg atgggcagga aagaggcagg ggccccagaa gcttctgtcc ctcatgcctg agggcacggg ggacacttgg annnnnnnnnnnnnnnnnnnnn nn agnggngt cgtccaaggc catgctctct gcggnctnnctnn gnctgtg

nnnnnnnnnn nnnnnnnnnn nnnccctctc agcccaacat cagcttcctc tttctccctt gctgtagaca ggctggat <210〉 92 <211> 586 <212〉 DNA <213> 人類 <220〉 <223> Probe 31825_at HG-U95Av2nnnnnnnnnn nnnnnnnnnn nnnccctctc agcccaacat cagcttcctc tttctccctt gctgtagaca ggctggat < 210〉 92 < 211 > 586 < 212〉 DNA < 213 > human < 220> < 223 > Probe 31825_at2HG-U-U

<221> misc一feature <222〉 39..64, 74, 96， 113， 118， 122， 142， 153， 162, 166， 175 <223> n 為 a，g, c 或 t <220〉 <221> misc^feature <222> 181, 195, 197, 224, 228, 249, 328, 418..434 <223> n 為 a，g，c 或 t <400> 92 gaaacgacca agaagagagg cttgttggaa tcaattctnn nnnnnnnnnn nnnnnnnnnn 98677.doc -61 - 200533758 nnnntagaag tcantgtaac tgtagtgtgt ctgctngtta cctagagggt ctnacctncc 120 cnactcttca cagcaaacct gnagcagcgc gtncctaagc ancctncccg ctccnggtga 180 nccccatcct tgcanancct gactctgtca ctcaagcctt tctnccancc aggcccctca 240 tctgaatanc caagcacaga aatgagtggt gtgactaatt ccttacctct cccaaggagg 300 gtacacaact agcaccattc ttgatgtncc agggaagaag ccacctcaag acatatgagg 360 420 480 540 586 ggtgccctgg gctaatgtta gggcttaatt ttctcaaagc ctgacctttc aaatccannn< 221 > misc-feature < 222> 39..64, 74, 96, 113, 118, 122, 142, 153, 162, 166, 175 < 223 > n is a, g, c or t < 220〉 < 221 > misc ^ feature < 222 > 181, 195, 197, 224, 228, 249, 328, 418..434 < 223 > n is a, g, c or t < 400 > 92 gaaacgacca agaagagagg cttgttggaa tcaattctnn nnnnnnnnnn nnnnnnnnnn 98677.doc -61 - 200533758 nnnntagaag tcantgtaac tgtagtgtgt ctgctngtta cctagagggt ctnacctncc 120 cnactcttca cagcaaacct gnagcagcgc gtncctaagc ancctncccg ctccnggtga 180 nccccatcct tgcanancct gactctgtca ctcaagcctt tctnccancc aggcccctca 240 tctgaatanc caagcacaga aatgagtggt gtgactaatt ccttacctct cccaaggagg 300 gtacacaact agcaccattc ttgatgtncc agggaagaag ccacctcaag acatatgagg 360 420 480 540 586 ggtgccctgg gctaatgtta gggcttaatt ttctcaaagc ctgacctttc aaatccannn

nnnnnnnnnn nnnnccctcc tgctgttgcc tccctgtgac ctggaggaca gtgtgtgcca tgtctcccat actagagata aataaatgta gccacattta ctgtnaaaaa aaaaaaaaaa aaactcgagg ggggccggta cccaattcgc cctatagctg agtcgt <210〉 93 <211〉 525 <212> DNA <213> 1 類 <220> <223〉 Probe 31862—at HG-U95Av2 <220〉 <221> misc一feature <222〉 （388)..(392) <223〉n 為 a，g，c 或 t <220> <221> misc—feature <222〉 （395)..(402) <223〉n 為 a，g，c 或 t 98677.doc -62- 200533758 <220> <221〉mi sc一feature <222〉 （405)..(412) <223〉n 為 a，g，c 或 t <400〉 93 acatcccctc agttgcagtg aattgtgagc aaaagatctt gaaagcaaaa agcactaatt agtttaaaat gtcacttttt tggtttttat tatacaaaaa ccatgaagta ctitttttat ttgctaaatc agattgttcc tttttagtga ctcatgttta tgaagagagt tgagtttaac aatcctagct tttaaaagaa actatttaat gtaaaatatt ctacatgtca ttcagatatt atgtatatct tctagccttt attctgtact tttaatgtac atatttctgt cttgcgtgat ttgtatattt cactggttta aaaaacaaac atcgaaaggc ttatgccaaa tggaagatag aatataaaat aaaacgttac ttgtatannn nnaannnnnn nnaannnnnn nncagataat tcatgtggag atttttggag aaaccatgac ggatagttta ggatgactac atgtcaaagt aataaaagag tggtgaattt taccaaaacc aagctatttg gaagc <210> 94 <211> 193 <212> DNA <213>人類 <220〉 <223〉 Probe 31895—at HG-U95Av2 <400〉 94 agtcttggtt ctccatctgt aatttttttt aacagtttgc tatagcttac tgcttaacta 98677.doc -63- 200533758 attttaaata aggaaataag tatgttagat gcagtagacg atacaggttg catgtggaca 120 ctcagtcaca ttaacaactt gggaaaaaaa tggcaatgtt acggtgaatt ctcaggtgaa 180 cttttttcag tta 193 <210〉 95 <211> 423 <212〉 DNA <213>人類 春 <220〉 <223> Probe 31974—at HG-U95Av2 <220〉 <221〉 misc一feature <222> 54, 117, 118, 125, 126, 216, 231, 232, 339..362 <223> n 為 a，g，c 或 t <400〉 95 cagcggcatg aagtttgaga ttggccaggc cctgtacctg ggcttcatct cctncgtccc 60nnnnnnnnnn nnnnccctcc tgctgttgcc tccctgtgac ctggaggaca gtgtgtggcaca tgtctcccat actagagata aataaatgta gccacattta ctgtnaaaaa aaaaaaaaaa aaactcgagg ≫210; <210; <212; < 212 > > > > > < 212 > HG-U95Av2 < 220〉 < 221 > misc-feature < 222〉 (388) .. (392) < 223〉 n is a, g, c or t < 220 > < 221 > misc-feature < 222〉 (395) .. (402) < 223〉 n is a, g, c or t 98677.doc -62- 200533758 < 220 > < 221〉 mi sc-feature < 222〉 (405 ) .. (412) < 223> n is a, g, c or t < 400> 93 acatcccctc agttgcagtg aattgtgagc aaaagatctt gaaagcaaaa agcactaatt agtttaaaat gtcacttttt tggtttttat tatacaaaaa ccatgaagta ctitttttat ttgctaaatc agattgttcc tttttagtga ctcatgttta tgaagagagt tgagtttaac aatcctagct tttaaaagaa actatttaat gtaaaatatt ctacatgtca ttcagatatt atgtatatct tctagccttt attctgtact tttaatgtac atatttctgt cttgcgtgat ttgtatattt cactggttta aaaaacaaac atcgaaaggc tt atgccaaa tggaagatag aatataaaat aaaacgttac ttgtatannn nnaannnnnn nnaannnnnn nncagataat tcatgtggag atttttggag aaaccatgac ggatagttta ggatgactac atgtcaaagt aataaaagag tggtgaattt taccaaaacc aagctatttg gaagc < 210 > 94 < 211 > 193 < 212 > DNA < 213 > human < 220> < 223> Probe 31895- at HG-U95Av2 < 400> 94 agtcttggtt ctccatctgt aatttttttt aacagtttgc tatagcttac tgcttaacta 98677.doc -63- 200533758 attttaaata aggaaataag tatgttagat gcagtagacg atacaggttg catgtggaca 120 ctcagtcaca ttaacaactt gggaaaaaaa tggcaatgtt acggtgaatt ctcaggtgaa 180 cttttttcag tta 193 < 210> 95 < 211 > 423 < 212> DNA < 213 > Human Spring < 220> < 223 > Probe 31974—at HG-U95Av2 < 220> < 221〉 misc-feature < 222 > 54, 117, 118, 125, 126, 216, 231, 232, 339..362 < 223 > n is a, g, c or t < 400〉 95 cagcggcatg aagtttgaga ttggccaggc cctgtacctg ggcttcatct cctncgtccc 60

tctcgctcat tggtggcacc ctgctttgcc tgtcctgcca ggacgaggca ccctacnngc 120 cctannccag gccccgccca gggccaccac gaccactgca aacaccgcac ctgcctacca 180 gccaccagct gcctacaaag acaatcgggc cccctnagtg acctcggcca nncacagcgg 240 gtacaggctg aacgactacg tgtgagtccc cacagcctgc ttctcccctg ggctgctgtg 300 ggctggttcc cggcgggact gtcaatggag gcaggggtnn nnnnnnnnnn nnnnnnnnnn 360 nncaattttt gtatccaagg aaataatgtg aatgcgagga aatgtcttta gagcacaggg 420 aca 423 98677.doc -64- 200533758 <210〉 96 <211〉 393 <212> DNA <213> 人類 <220〉 <223〉 Probe 32034—at HG-U95Av2 <400〉 96 cctgttcaca agctgagcca tatgtacata atctagatti tgtiitcata gttttgcact tttatagcct atccaatgag gtgataatag tgaaaacaag accacatttc atatgttttt atttttgaag tgttacagag agggctggaa tcgatttgta tgaatgtata gtgtccatca attaacacat agcttgctgt tttaaacctg ttatgctgga aaaataccaa gtattaacta ttgcaagatg gactagaacc tatttaaaaa attttttggg ttattttcct ttg attgactcaa ataaatctta aaagaatcac ctttcagatt acagcccttt tctttgccta aagggggtat caaatctatt tctcttttta gtacttcaaa 60 120 180 240 300 360 393tctcgctcat tggtggcacc ctgctttgcc tgtcctgcca ggacgaggca ccctacnngc 120 cctannccag gccccgccca gggccaccac gaccactgca aacaccgcac ctgcctacca 180 gccaccagct gcctacaaag acaatcgggc cccctnagtg acctcggcca nncacagcgg 240 gtacaggctg aacgactacg tgtgagtccc cacagcctgc ttctcccctg ggctgctgtg 300 ggctggttcc cggcgggact gtcaatggag gcaggggtnn nnnnnnnnnn nnnnnnnnnn 360 nncaattttt gtatccaagg aaataatgtg aatgcgagga aatgtcttta gagcacaggg 420 aca 423 98677.doc -64- 200533758 < 210> 96 < 211> 393 < 212 > DNA < 213 > Human < 220> < 223〉 Probe 32034-at HG-U95Av2 < 400> 96 cctgttcaca agctgagcca tatgtacata atctagatti tgtiitcata gttttgctag tcgta tacta tgaaaacaag accacatttc atatgttttt atttttgaag tgttacagag agggctggaa tcgatttgta tgaatgtata gtgtccatca attaacacat agcttgctgt tttaaacctg ttatgctgga aaaataccaa gtattaacta ttgcaagatg gactagaacc tatttaaaaa attttttggg ttattttcct ttg attgactcaa ataaatctta aaagaatcac ctttcagatt acagcccttt tctttgccta aagggggtat caaatctatt tctcttttt a gtacttcaaa 60 120 180 240 300 360 393

97 114 DNA 人類 <210〉 <211〉 <212〉 <213〉 <220〉 <223〉 Probe 32052一at HG-U95Av2 <400> 97 60 gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac taaactgg找 gatattatga agggccttga gcatctggat tctgcctaat aaaa 98677.doc -65 - 11497 114 DNA human < 210〉 < 211〉 < 212〉 < 213〉 < 220〉 < 223〉 Probe 32052a at HG-U95Av2 < 400 > 97 60 gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa gtccaactac tatactg agggccttga gcatctggat tctgcctaat aaaa 98677.doc -65-114

200533758 <210> 98 <211> 479 <212〉 DNA <213〉人類 <220〉 <223〉 Probe 32114_s—at HG-U95Av2 <220〉 <221> misc_feature <222〉 48, 50, 55, 92， 135, 226..241 <223> n 為 a, g，c 或 t <400〉 98 agcttgggca cagcagactg gcctggccct gagactgggg agtggctncn acagncctcc tgccacccac acaccactct ccctagactc tncctagggt tcaggagctg ctgggcccag aggtgacatt tgacnttttt tccaggaaaa atgtaagtgt gaggaaaccc tttttatttt attacctttc actctctggc tgctgggtct gccgtcggtc ctgctnnnnn nnnnnnnnnn ngagcctctg cccggggagc ctcaggcagt cctctcctgc tgtcacagct gccatccact tctcagtccc agggccatct cttggagtga caaagctggg atcaaggaca gggagttgta acagagcagt gccagagcat gggcccaggt cccaggggag aggttggggc tggcaggcca ctggcatgtg ctgagtagcg cagagctacc cagtgagagg ccttgtctaa ctgcctttc <210> 99 <211> 55 <212〉 DNA <213>人類 60 120 180 240 300 360 420 479 98677.doc -66- 200533758 <220〉 <223> Probe 32115_r_at HG-U95Av2 <400〉 99 ggtctgccgt cggtcctgct gctaacctgg cagcagagcc tctgcccggg gagcc <210> 100 <211〉 541 <212〉 DNA <213>人類 籲 <220〉 <223> Probe 32168_s—at HG-U95Av2 <220> <221> misc_feature <222> (125)..(125) <223> n 為 a，g，c 或 t200533758 < 210 > 98 < 211 > 479 < 212〉 DNA < 213〉 human < 220〉 < 223〉 Probe 32114_s—at HG-U95Av2 < 220> < 221 > misc_feature < 222〉 48 , 50, 55, 92, 135, 226..241 < 223 > n is a, g, c or t < 400> 98 agcttgggca cagcagactg gcctggccct gagactgggg agtggctncn acagncctcc tgccacccac acaccactct ccctagactc tncctagggt tcaggagctg ctgggcccag aggtgacatt tgacnttttt tccaggaaaa atgtaagtgt gaggaaaccc tttttatttt attacctttc actctctggc tgctgggtct gccgtcggtc ctgctnnnnn nnnnnnnnnn ngagcctctg cccggggagc ctcaggcagt cctctcctgc tgtcacagct gccatccact tctcagtccc agggccatct cttggagtga caaagctggg atcaaggaca gggagttgta acagagcagt gccagagcat gggcccaggt cccaggggag aggttggggc tggcaggcca ctggcatgtg ctgagtagcg cagagctacc cagtgagagg ccttgtctaa ctgcctttc < 210 > 99 < 211 > 55 < 212> DNA < 213 > human 60 120 180 240 300 360 420 479 98677.doc -66- 200533758 < 220〉 < 223 > Probe 32115_r_at HG-U95Av2 < 400> 99 ggtctgccgt cggtcctgct gctaacctgg cagcaga gcc tctgcccggg gagcc < 210 > 100 < 211〉 541 < 212〉 DNA < 213 > Human Appeal < 220〉 < 223 > Probe 32168_s-at HG-U95Av2 < 220 > < 221 > misc_feature < 222 > (125) .. (125) < 223 > n is a, g, c or t

<400〉 100 aacctacctg ttcaaagcat ccccnattca tgtaatgtgt tttgtcattt ggttttattc aaattgattg gagagaccat tgaatcatat gtcaagtgga ttcctgatgg atgtctggta tgaaatactt tttgagaagc aacgttctca tgcatcgctg gttgtaggaa tagtagatct aattgttata aataggtatt aatgccaagt aaatatgttt aaccctgttt tccaagtgtt aagctgttcc gtggcgatat ctaggttaac atattttggc aacaatgcat gcattaaatg acggtacttg tcttgttaag catgtctaac gagagggatg atttgtaatt cttacaatac gctttggaaa ctttgattgt gtaagaggga tgcttttaaa aggacttgaa cagtgccttt tttttctagt cgtaacaatg tttggaagat tcatatcaag gccggtttgg ctggagaggc 98677.doc -67- 200533758 taacctcaaa atattttttt taactgcatt ctataataaa tgggcacagt atgctcctta c <210〉 101 <211> 60 <212> DNA <213>人類 <220〉≪ 400> 100 aacctacctg ttcaaagcat ccccnattca tgtaatgtgt tttgtcattt ggttttattc aaattgattg gagagaccat tgaatcatat gtcaagtgga ttcctgatgg atgtctggta tgaaatactt tttgagaagc aacgttctca tgcatcgctg gttgtaggaa tagtagatct aattgttata aataggtatt aatgccaagt aaatatgttt aaccctgttt tccaagtgtt aagctgttcc gtggcgatat ctaggttaac atattttggc aacaatgcat gcattaaatg acggtacttg tcttgttaag catgtctaac gagagggatg atttgtaatt cttacaatac gctttggaaa ctttgattgt gtaagaggga tgcttttaaa aggacttgaa cagtgccttt tttttctagt cgtaacaatg tttggaagat tcatatcaag gccggtttgg ctggagaggc 98677.doc -67- 200533758 taacctcaaa atattttttt taactgcatt ctataataaa tgggcacagt atgctcctta c < 210〉 101 < 211 > 60 < 212 > DNA < 213 > human < 220〉

<223〉Probe 32215一;Lat HG-U95Av2 <400〉 101 aacagattac tgtctattgt cagcatcatt ttcatctgta agtcactact ggaatatatt <210> 102 <211> 202 <212〉 DNA <213> 人類 <220〉 <223〉 Probe 32216—r—at HG-U95Av2< 223〉 Probe 32215 一; Lat HG-U95Av2 < 400〉 101 aacagattac tgtctattgt cagcatcatt ttcatctgta agtcactact ggaatatatt < 210 > 102 < 211 > 202 < 212> DNA < 213 > Human < 220> < 223 〉 Probe 32216-r-at HG-U95Av2

<221〉 misc一feature <222> (78)..(78) <223〉n 為 a，g，c 或 t <400〉 102 aaatggactg ggatagagga cagactgata gtttctttct ttcatatcac atgtatagag aaataattat atcagaanct cacaaaccta gacatggaaa aacagattac tgtctattgt cagcatcatt ttcatctgta agtcactact ggaatatatt tttcttttaa tttccagtga 98677.doc -68- 202 200533758 ctttagaata cacacagttt tt <210〉 103 <211> 171 <212〉 DNA <213>人類 <220〉 <223> Probe 32285_g—at HG-U95Av2 <400〉 103< 221〉 misc-feature < 222 > (78) .. (78) < 223〉 n is a, g, c or t < 400> 102 aaatggactg ggatagagga cagactgata gtttctttctct ttcatatcac atgtatagag aaataattat ccagaanct cacaacatt aggatgatgat ttcatctgta agtcactact ggaatatatt tttcttttaa tttccagtga 98677.doc -68- 202 200533758 ctttagaata cacacagttt tt < 210〉 103 < 211 > 171 < 212〉 DNA < 213 > human < 220〉 < 223 > Probe 32285_g U95Av2 < 400> 103

60 120 171 ctatgtggac ccacgcaaag atagcgagaa atatgccgag gagaacttca aaacctttgt gttcgaggag acacgattca ccgcggtcac tgcctaccag aaccatcgga tcacgcagct caagattgcc agcaatccct tcgcgaaagg cttccgggac tgtgaccctg a <210> 104 <211> 279 <212〉 DNA <213>人類 <220> <223> Probe 32319—at HG-U95Av2 <400〉 104 gtctatgttc tatttttttc gttatcaatt atccaaatca ttgtatttag ttgttgctat tggacaagct gttagttaga taatttgttc tgctttcctg gagtcaagga tacatcttcc tattttctat ttaagtatac gctctcagag gtgtaacctt tcagccatct ttagagaatg tgggcaggtc agtattaat ctcctttact ttgtgagtcc cttaagggat ccctatttta atgttgaatg ttcaagagca tccaatcccg agtcataatt 60 120 180 240 279 98677.doc -69- 200533758 <210> 105 <211> 439 <212〉 DNA <213>人類 <220〉 <223> Probe 32321 at HG-U95Av2 <220〉 <221> misc^feature <222〉 （118)..(356) _ <223> n 為 a，g，c 或 t <400> 10560 120 171 ctatgtggac ccacgcaaag atagcgagaa atatgccgag gagaacttca aaacctttgt gttcgaggag acacgattca ccgcggtcac tgcctaccag aaccatcgga tcacgcagct caagattgcc agcaatccct tcgcgaaagg cttccgggac tgtgaccctg a < 210 > 104 < 211 > 279 < 212> DNA < 213 > human < 220 > < 223 > Probe 32319-at HG-U95Av2 < 400> 104 gtctatgttc tatttttttc gttatcaatt atccaaatca ttgtatttag ttgttgctat tggacaagct gttagttaga taatttgttc tgctttcctg gagtcaagga tacatcttcc tattttctat ttaagtatac gctctcagag gtgtaacctt tcagccatct ttagagaatg tgggcaggtc agtattaat ctcctttact ttgtgagtcc cttaagggat ccctatttta atgttgaatg ttcaagagca tccaatcccg agtcataatt 60 120 180 240 279 98677.doc -69- 200533758 < 210 > 105 < 211 > 439 < 212〉 DNA < 213 > human < 220〉 < 223 > Probe 32321 at HG-U95Av2 < 220〉 < 221 > misc ^ feature < 222〉 (118) .. (356) _ < 223 > n is a, g, c or t < 400 > 105

ccacagagag cctccactag agtgatgcta agtggaaatg tgaggtgcag ctgccacaga gggcccccac cagggaaatg tctagtgtct agtggatcca ggccacagga gagagtgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntccc acagatacct tttctctccc atgacccttt aacagcatct gcttcattcc cctcaccttc ccaggctgat ctgaggtaa <210> 106 <211> 270 <212> DNA <213>人類 98677.doc -70- 200533758 <220> <223> Probe 32464—at HG-U95Av2 <220〉 <221> misc_feature <222〉 （167)..(219) <223〉n 為 a，g，c 或 t <400〉 106 gagggtcttg tatctcctct tctcgttcct cttcatattc ctgatgcctc ttccaggigi ttttggtggt cttttgccct nnnnnnnnnn ctcatcagag ataggcgatc agaaggtata nnnnnnnnnn acgtgcgaca ctgttacctg aacaaattgg nnnnnnnnnn tgtaaaccaa ccttaagagt cacctgtggt nnnnnnnnnt ggagccatat ctccctnnnn gcggattcag gtcatccagt nnnnnnnnnn aaagggctccccacagagag cctccactag agtgatgcta agtggaaatg tgaggtgcag ctgccacaga gggcccccac cagggaaatg tctagtgtct agtggatcca ggccacagga gagagtgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntccc acagatacct tttctctccc atgacccttt aacagcatct gcttcattcc cctcaccttc ccaggctgat ctgaggtaa < 210 > 106 < 211 > 270 < 212 > DNA < 213 > human 98677.doc -70- 200533758 < 220 > < 223 > Probe 32464—at HG-U95Av2 < 220> < 221 > misc_feature < 222> ( 167) .. (219) < 223> n is a, g, c or t < 400> 106 gagggtcttg tatctcctct tctcgttcct cttcatattc ctgatgcctc ttccaggigi ttttggtggt cttttgccct nnnnnnnnnn ctcatcagag ataggcgatc agaaggtata nnnnnnnnnn acgtgcgaca ctgttacctg aacaaattgg nnnnnnnnnn tgtaaaccaa ccttaagagt cacctgtggt nnnnnnnnnt ggagccatat ctccctnnnn gcggattcag gt catccagt nnnnnnnnnn aaagggctcc

<210> 107 <211〉 445 <212> DNA <213>人類 <220> <223> Probe 3253Lat HG-U95Av2 <400〉 107 tagtactgta gactattaaa aatacacagt agcaactttg aacaggcttt tgtgcctaaa aattcagaac atgtttgcac agtcattaat tgaattttgc ttgtattcta taagatttta gtgagagact agtaactggt ttatgagttt tttggaatgc tagaaaaaat attcttgggt agcagtcttt aagagaggtt gcttagagtg tttcctactt tggagtgacc gaaagaggat 98677.doc -71 - 200533758 tcagtagtac tccaaatgcc tttcttcttg gtttgacatt acatacaact ttttttaaaa catgcatgtc ccatgttaaa aatttatttg ctcatcacag agctacataa ctacg aactatatgt aagattggtg acagttttgt tgaagacatc aaaatgctga acaatgaaaa taccagtttc gtatgacact ttactaattt <210> 108 <211〉 480 <212> DNA 籲<213〉人類 <220〉 <223> Probe 32551一at HG-U95Av2 <220〉 <221> misc一feature <222> (64..76, 78..81, 83..89, 100, 102) <223> n 為 a, g，c 或 t< 210 > 107 < 211> 445 < 212 > DNA < 213 > human < 220 > < 223 > Probe 3253Lat HG-U95Av2 < 400> 107 tagtactgta gactattaaa aatacacagt agcaactttg aacaggcttt tcggat cattaatt agt gtgagagact agtaactggt ttatgagttt tttggaatgc tagaaaaaat attcttgggt agcagtcttt aagagaggtt gcttagagtg tttcctactt tggagtgacc gaaagaggat 98677.doc -71 - 200533758 tcagtagtac tccaaatgcc tttcttcttg gtttgacatt acatacaact ttttttaaaa catgcatgtc ccatgttaaa aatttatttg ctcatcacag agctacataa ctacg aactatatgt aagattggtg acagttttgt tgaagacatc aaaatgctga acaatgaaaa taccagtttc gtatgacact ttactaattt < 210 > 108 < 211> 480 < 212 > DNA call < 213〉 Human < 220> < 223 > Probe 32551-at HG-U95Av2 < 220> < 221 > misc-feature < 222 > (64..76, 78 .. 81, 83..89, 100, 102) < 223 > n is a, g, c or t

<400〉 108 attttcatat atannnnnnn tgtaaaaaac aaattatact cattggaact cttccacaag taagtaaaat ccagcctaaa nnnnnnannn agtaagcaaa attgagaaat gacctgaaga atgcagaaca ttaaatccta ggtggttgtt nannnnnnnt attttccaga ctatggggag agcaaactcg aaatggataa acacttcact tattatatag tttgtcagan attcccaaaa gatatgagaa gaaaatataa aaggtatttc aatttataac taataaatca antttagatt tgaaccagat aataaattcc taacatccct actggagaag taaaatttct ttgctgtaca gtgaatattt atcccctaga ttctaaacca gaattcagga ttttaatttc catcttcgta 986^7.doc -72- 200533758 cttgatgctc acagaggaag aaaatgatga tggtttttat tcctggcatc cagagtgaca 480 <210> 109 <211> 177 <212〉 DNA <213>人類 <220〉 <223〉 Probe 32588—s_at HG-U95Av2≪ 400> 108 attttcatat atannnnnnn tgtaaaaaac aaattatact cattggaact cttccacaag taagtaaaat ccagcctaaa nnnnnnannn agtaagcaaa attgagaaat gacctgaaga atgcagaaca ttaaatccta ggtggttgtt nannnnnnnt attttccaga ctatggggag agcaaactcg aaatggataa acacttcact tattatatag tttgtcagan attcccaaaa gatatgagaa gaaaatataa aaggtatttc aatttataac taataaatca antttagatt tgaaccagat aataaattcc taacatccct actggagaag taaaatttct ttgctgtaca gtgaatattt atcccctaga ttctaaacca gaattcagga ttttaatttc catcttcgta 986 ^ 7 .doc -72- 200533758 cttgatgctc acagaggaag aaaatgatga tggtttttat tcctggcatc cagagtgaca 480 < 210 > 109 < 211 > 177 < 212〉 DNA < 213 > human < 220〉 < 223〉 Probe 32588-95_Av2

<400〉 109 catctccgac gactgaggca agagggcgcc agtgaggagg aagggaaggc ggttcagaga tgttggagga cacccctcgc catctcgccc ttgctggggg cacgggagtg gggggggtga catgggccct aggcagactg caagcccgac cgagcacttg gactcgaact ctgtgcc 60 120 177 <210〉 110 <211> 534 <212〉 DNA <213> 讀< 400〉 109 catctccgac gactgaggca agagggcgcc agtgaggagg aagggaaggc ggttcagaga tgttggagga cacccctcgc catctcgccc ttgctggggg cacgggagtg gg &212; > 210 & 210

<220> <223> Probe 32606_at HG-U95Av2 <220> <221> misc_feature <222> 276, 277, 290, 293..297, 368..406, 441, 442 <223〉n 為 a，g, c 或 t <400〉 110 acagaactac aggtgcaccc aaccacggac atgcattaac tcgtcatgag aaatctaggt aggctaagta ggatgagaga atgtttgtca ctcccaaaaa tatctggaga ggaagaatgg 60 98677.doc -73- 120 180 180< 220 > < 223 > Probe 32606_at HG-U95Av2 < 220 > < 221 > misc_feature < 222 > 276, 277, 290, 293..297, 368..406, 441, 442 < 223〉 n Is a, g, c or t < 400〉 110 acagaactac aggtgcaccc aaccacggac atgcattaac tcgtcatgag aaatctaggt aggctaagta ggatgagaga atgtttgtca ctcccaaaaa tatctggaga ggaagaatgg 60 98677.doc -73- 120 180 180

200533758 aggattggca ttgagatcca tgtggacaag ctaagtgggc tctgtctgaa agctggcatt catccacaac attaaaaaaa tatcaaaata agaaaggctg taaattaaaa agaaaacaca gaaaatactg ctctcataaa gatctgattg ccttgnnaca ggccctgtgn gannnnntca aacgcatcac tcccaactcc cattgcagaa gaaaagctat tcaactctca gcggtggagg agtgcatnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncaga cgcggatctt ggaaatccag gacttcttgg nnaagttgac tgaaggtata ttagatattt ccccacaaaa atactatttg gattctccca ccccctccct cccttgatgg gacaacatcc tgta <210〉 111 <211〉 45 <212〉 DNA <213>人類 <220〉 <223> Probe 32609—at HG-U95Av2 240 300 360 420 480 534200533758 aggattggca ttgagatcca tgtggacaag ctaagtgggc tctgtctgaa agctggcatt catccacaac attaaaaaaa tatcaaaata agaaaggctg taaattaaaa agaaaacaca gaaaatactg ctctcataaa gatctgattg ccttgnnaca ggccctgtgn gannnnntca aacgcatcac tcccaactcc cattgcagaa gaaaagctat tcaactctca gcggtggagg agtgcatnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncaga cgcggatctt ggaaatccag gacttcttgg nnaagttgac tgaaggtata ttagatattt ccccacaaaa atactatttg gattctccca ccccctccct cccttgatgg gacaacatcc tgta < 210> 111 < 211〉 45 < 212〉 DNA < 213 > Human < 220> < 223 > Probe 32609-at HG-U95Av2 240 300 360 420 480 534

<400〉 111 gcccgcgtct cgaaggggca cctgtgaact caaaaggctc ttttc 45 <210〉 112 <211> 505 <212> DNA <213>人類 <220> <223> Probe 32610_at HG-U95Av2 <220〉 <221〉 misc一feature 98677.doc -74- 60 200533758 <222〉 35, 90， 102， 130， 131， 187, 380, 383, 437 <223〉n 為 a，g，c 或 t <400> 112 acctgggctc cgaggtgtac aggatgctgc ggganccagc cgagcccgtg gccgcggagc ccaagcagtc aggctccttc cgctacttgn agggcatgct anaggccggc gagggcgggg attggcccgn ncctggcggc ccccggaacc tcaagcccac ggccagcaag ctgggcgctc cgctgancgg cctgcagggg ctgcccgagt gcacgcgctg cggccacggc atcgtgggca ccatcgtcaa gcctgaacct acgccaaggc ccaaggtgga ctcggccggt ggcacgggac caagcagcgt gcgcgtgaan actcgtntga gtaaatatgt aagctctacc ggttacttct ccncccgagg gctgggaccc t tcac atcccgagtg ttctggacga gctacgacgt tgctcccacg cttcatgtgc gcggctctac ggtggcggtg cctgcttctt agtgactgcg tgtgagagcc taccccaatg aaggtccctg 120 180 240 300 360 420 480 505< 400> 111 gcccgcgtct cgaaggggca cctgtgaact caaaaggctc ttttc 45 < 210〉 112 < 211 > 505 < 212 > DNA < 213 > human < 220 > < 223 > Probe 32610_at HG-U95Av2 < 220 221〉 misc-feature 98677.doc -74- 60 200533758 < 222〉 35, 90, 102, 130, 131, 187, 380, 383, 437 < 223> n is a, g, c or t < 400 > 112 acctgggctc cgaggtgtac aggatgctgc ggganccagc cgagcccgtg gccgcggagc ccaagcagtc aggctccttc cgctacttgn agggcatgct anaggccggc gagggcgggg attggcccgn ncctggcggc ccccggaacc tcaagcccac ggccagcaag ctgggcgctc cgctgancgg cctgcagggg ctgcccgagt gcacgcgctg cggccacggc atcgtgggca ccatcgtcaa gcctgaacct acgccaaggc ccaaggtgga ctcggccggt ggcacgggac caagcagcgt gcgcgtgaan actcgtntga gtaaatatgt aagctctacc ggttacttct ccncccgagg gctgggaccc t tcac atcccgagtg ttctggacga gctacgacgt tgctcccacg cttcatgtgc gcggctctac ggtggcggtg cctgcttctt agtgactgcg tgtgagagcc taccccaatg aaggtccctg 120 180 240 300 360 420 480 505

<210〉 113 <211> 350 <212> DNA <213>人類 <220〉 <223〉 Probe 32616—at HG-U95Av2 <400〉 113 aataccagca catttagaga tctgccgtgc gcagccttag ggaaaagtaa ctggatcctg agcacaggga ccatcactgg aaatagaggc gacccgtcca ttgcacttat taaattactc tttggcaggg gatttcatgt aggaagaaca gtggctgcct gcggggatca ccctctaaat 60 120 180 98677.doc -75- 200533758 gggaaagtat tctgtactct tagatggatt ctccactcag ttgcaacttg gacttgtcct cagcagctgg taatcttgct ctgcttgaca acatctgagt gcagccgttt gagaagaaaa catctattct ctccaaaaat gcacccaact agctctatgt ttacaaatgg <210> 114 <211〉 299 <212> DNA <213>人類 籲 <220> <223> Probe 32640—at HG-U95Av2 <220> <221> miscjeature <222> (256)..(273) <223〉 n 為 a，g，c 或 t <400> 114< 210> 113 < 211 > 350 < 212 > DNA < 213 > human < 220> < 223〉 Probe 32616-at HG-U95Av2 < 400> 113 aataccagca catttagaga tctgccgtgc gcagccttag ggaaaagtaa ctggatcgaccgcca cggca agcc ttgcacttat taaattactc tttggcaggg gatttcatgt aggaagaaca gtggctgcct gcggggatca ccctctaaat 60 120 180 98677.doc -75- 200533758 gggaaagtat tctgtactct tagatggatt ctccactcag ttgcaacttg gacttgtcct cagcagctgg taatcttgct ctgcttgaca acatctgagt gcagccgttt gagaagaaaa catctattct ctccaaaaat gcacccaact agctctatgt ttacaaatgg < 210 > 114 < 211> 299 < 212 > DNA < 213 > Human appeal < 220 > < 223 > Probe 32640-at HG-U95Av2 < 220 > < 221 > miscjeature < 222 > (256) .. (273) < 223> n is a, g, c or t < 400 > 114

gtgatttttc tatcggcaca aaagcactat atggactggt aatggttaca ggttcagaga ttacccagtg aggccttatt cctcccttcc ccccaaaact gacacctttg ttagccacct ccccacccac atacatttct gccagtgttc acaatgacac tcagcggtca tgtctggaca tgagtgccca gggaatatgc ccaagctatg ccttgtcctc ttgtcctgtt tgcatttcac tgggagcttg cactannnnn nnnnnnnnnn nnngcagtga tcagggtcct gcaagcagt <210> 115 <211> 431 <212> DNA <213>人類 98677.doc -76- 60 200533758 <220〉 <223> Probe 32668_at HG-U95Av2 <400〉 115 120 180 240 300 360 420 431gtgatttttc tatcggcaca aaagcactat atggactggt aatggttaca ggttcagaga ttacccagtg aggccttatt cctcccttcc ccccaaaact gacacctttg ttagccacct ccccacccac atacatttct gccagtgttc acaatgacac tcagcggtca tgtctggaca tgagtgccca gggaatatgc ccaagctatg ccttgtcctc ttgtcctgtt tgcatttcac tgggagcttg cactannnnn nnnnnnnnnn nnngcagtga tcagggtcct gcaagcagt < 210 > 115 < 211 > 431 < 212 > DNA < 213 > Human 98677.doc -76- 60 200533758 < 220> < 223 > Probe 32668_at HG-U95Av2 < 400> 115 120 180 240 300 360 420 431

tcccctcttt tgtgaagaaa gcgggtccaa atgtgattca aacaactgta cggagtggca tattagaatt gccctaaact gaactgcaaa taattatgtg tgtatgtata tgtgtgggaa agagaatgta ctgtatatgt gtatgttata cagacatata cacatacata cattgaccca caggacattg taaaatatta tcacatgaca tcttaagtag aaaiaagtag ggacttttat tccatccttt ttttcacgtt tacattttaa ttattacaag ttgctcctgc cccctccctg aactattttg tgctgtgtat atcactgctt tatataagtt attttttaag gtgaactcag atgttatggt tttgtaaatg tctgcaatca tggataggaa taaaatcgct tatttgagag ctttcattaa a <210〉 116 <211> 482 <212〉 DNA <213>人類 <220> <223> Probe 32700—at HG-U95Av2 <220〉 <221> miscjeature <222> 29, 65, 66, 72..105, 230..245, 420..434 <223> n 為 a, g，c 或 t <400〉 116 agtactacca ggtgccaagg aaggggatnc aggccaaaga ggtgctgaaa aaatatttgg 60 98677.doc -77- 200533758 agtcnnagga gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncactc tcagaaaagg aaaaagcgat tgaagtggaa cgtataaagg ctgaatctgc agaagctgca aagaaaatgt tggaggaaat acaaaagaag aatgaggaga tgatggaaca gaaagagaan nnnnnnnnnn nnnnngtgaa acaattgact gagaagatgg agagggacag ggcccagtta atggcagagc aagagaagac cctcgctctt aaacttcagg aacaggaacg ccttctcaag gagggattcg agaatgagag caagagactt caaaaagaca tatgggatat ccagatgaga agcaaatcantcccctcttt tgtgaagaaa gcgggtccaa atgtgattca aacaactgta cggagtggca tattagaatt gccctaaact gaactgcaaa taattatgtg tgtatgtata tgtgtgggaa agagaatgta ctgtatatgt gtatgttata cagacatata cacatacata cattgaccca caggacattg taaaatatta tcacatgaca tcttaagtag aaaiaagtag ggacttttat tccatccttt ttttcacgtt tacattttaa ttattacaag ttgctcctgc cccctccctg aactattttg tgctgtgtat atcactgctt tatataagtt attttttaag gtgaactcag atgttatggt tttgtaaatg tctgcaatca tggataggaa taaaatcgct tatttgagag ctttcattaa a < 210> 116 < 211 > 482 < 212> DNA < 213 > human < 220 > < 223 > Probe 32700-at HG-U95Av2 < 220> < 221 > miscjeature < 222 > 29, 65, 66, 72. .105, 230..245, 420..434 < 223 > n is a, g, c or t < 400〉 116 agtactacca ggtgccaagg aaggggatnc aggccaaaga ggtgctgaaa aaatatttgg 60 98677.doc -77- 200533758 agtcnnagga gnnnnnnnnnnnnnnnnnnnnnnnnnnnnn aaaaagcgat tgaagtggaa cgtataaagg ctgaatctgc agaagctgca aagaaaatgt tggaggaaat acaaaagaag aatgaggaga tgatggaaca gaaag agaan nnnnnnnnnn nnnnngtgaa acaattgact gagaagatgg agagggacag ggcccagtta atggcagagc aagagaagac cctcgctctt aaacttcagg aacaggaacg ccttctcaag gagggattcg agaatgagag caagagactt caaaaagaaga tat

nnnnnnnnnn nnnnaacata ctctaaaagt ccaaggagca aaatttgcct gtccagctcc ct <210> 117 <211> 441 <212> DNA <213>人類 <220〉 <223> Probe 32718_at HG-U95Av2nnnnnnnnnn nnnnaacata ctctaaaagt ccaaggagca aaatttgcct gtccagctcc ct < 210 > 117 < 211 > 441 < 212 > DNA < 213 > human < 220〉 < 223 > Probe 32718_at HG-U95Av2

<221> misc_feature <222> 41..44, 46..48, 58..74, 218 <223〉 n 為 a，g，c 或 t <400〉 117 cagactgagc aagtggagta gcagaaccag gagcctcttc nnnncnnnag gaaagatnnn nnnnnnnnnn nnnnaaggga aattcctagg attggctgtc ccctgccaag cttggtggag cgtctgcacc ttggctgcgc cgcctgtgca tttgccagtt tcctcccact gagaggatgg 98677.doc -78- 240 200533758 300 360 420 441 aggtgtccgc acagctttgg gcctcgtgag ggatctgncc tcctgagcaa agagctcttg atcccgattt catgcacagc cctgcagtaa ggagcccaga aggaacatgt gtttcctgtt aaaactcctc ttgttctctt ttcttacatt atgacgtttg ttttcaagga gagggtttaa aaatgggatc ctgtaagcag acttgggcag tctccttttg aaataggttg tctgtacatg ttctaatgtt ttgtagaaca c <210> 118 ® <211> 498 <212〉 DNA <213〉人類 <220〉 <223> Probe 32736—at HG-U95Av2 <220> <221> misc_feature <222> (77)..(91) <223〉n 為 a，g，c 或 t< 221 > misc_feature < 222 > 41..44, 46..48, 58..74, 218 < 223〉 n is a, g, c or t < 400〉 117 cagactgagc aagtggagta gcagaaccag gagcctcttc nnnncnnnag gannagannnnn nnnnaaggga aattcctagg attggctgtc ccctgccaag cttggtggag cgtctgcacc ttggctgcgc cgcctgtgca tttgccagtt tcctcccact gagaggatgg 98677.doc -78- 240 200533758 300 360 420 441 aggtgtccgc acagctttgg gcctcgtgag ggatctgncc tcctgagcaa agagctcttg atcccgattt catgcacagc cctgcagtaa ggagcccaga aggaacatgt gtttcctgtt aaaactcctc ttgttctctt ttcttacatt atgacgtttg ttttcaagga gagggtttaa aaatgggatc ctgtaagcag acttgggcag tctccttttg aaataggttg tctgtacatg ttctaatgtt ttgtagaaca c < 210 > 118 ® < 211 > 498 < 212〉 DNA < 213〉 human < 220〉 < 223 > Probe 32736-at HG-U95Av2 < 220 > < 221 > misc_feature < 222 > ( 77) .. (91) < 223> n is a, g, c or t

<221> misc一feature <222〉 （218)..(220) <223> n 為 a，g，c 或 t <220〉 <221〉 misc_feature <222〉 （222)..(268) <223> n 為 a, g，c 或 t 98677.doc _-< 221 > misc-feature < 222〉 (218) .. (220) < 223 > n is a, g, c or t < 220〉 < 221〉 misc_feature < 222〉 (222) .. (268) < 223 > n is a, g, c or t 98677.doc _-

200533758 <220> <221> misc一feature <222〉 （425)..(425) <223> η 為 a，g，c 或 t <400〉 118 tcctgccttc ctgagggcca gaggggagcc ccaggaccca ttaagccacc cccgtgttcc tgccgtcagt gccaacnnnn nnnnnnnnnn ncatctaccc gttcactcca gtcccacccc acgcctgact cccctctgga aactgcaggc cagatggttg ctgccacaac ttgtgtacct tcagggatgg ggctcttact ccctcctgag gccagctnnn cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnaa atgagtgtct cagaagtgtg ctcctctggc ctcagttctc ctcttttgga acaacataaa acaaatttaa ttttctacgc ctctggggat atctgctcag ccaatggaaa atctgggttc aaccagcccc tgccatttct taagactttc tgctncactc acaggatcct gagctgcact tacctgtgag agtcttcaaa cttttaaacc ttgccagtca ggactttt <210> 119 <211〉 494 <212〉 DNA <213>人類 <220〉 <223> Probe 32737^at HG-U95Av2 <220> <221> miscjeature <222> 207, 209..212, 261, 264, 269, 298, 310, 337..358, 373, 377 <223〉n 為 a, g，c 或 t 60 120 180 240 300 360 420 480 498 98677.doc -80-200533758 < 220 > < 221 > misc-feature < 222〉 (425) .. (425) < 223 > η is a, g, c or t < 400> 118 tcctgccttc ctgagggcca gaggggagcc ccaggaccca ttaagccacc cccnncagtgtc nnnnnnnnnn ncatctaccc gttcactcca gtcccacccc acgcctgact cccctctgga aactgcaggc cagatggttg ctgccacaac ttgtgtacct tcagggatgg ggctcttact ccctcctgag gccagctnnn cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnaa atgagtgtct cagaagtgtg ctcctctggc ctcagttctc ctcttttgga acaacataaa acaaatttaa ttttctacgc ctctggggat atctgctcag ccaatggaaa atctgggttc aaccagcccc tgccatttct taagactttc tgctncactc acaggatcct gagctgcact tacctgtgag agtcttcaaa cttttaaacc ttgccagtca ggactttt < 210 > 119 < 211 〉 494 < 212〉 DNA < 213 > human < 220> < 223 > Probe 32737 ^ at HG-U95Av2 < 220 > < 221 > miscjeature < 222 > 207, 209..212, 261, 264 , 269, 298, 310, 337..358, 373, 377 < 223〉 n is a, g, c or t 60 120 180 240 300 360 420 480 498 98677.doc -80-

200533758 <220〉 <221> misc—feature <222〉 380·.387, 389..392, 398, 402, 405, 407, 409, 410, 412..419 <223> n 為 a，g，c 或 t <220> <221> misc一feature <222〉 423, 424, 426, 429..462 <223> n 為 a，g，c 或 t <400> 119 acagacggac gtcttcctca tctgcttctc cctcgtcagc ccagcctctt atgagaacgt ccgcgccaag tggttcccag aagtgcggca ccactgcccc agcacaccca tcatcctggt gggcaccaag ctggacctgc gggacgacaa ggacaccatc gagaaactga aggagaagaa gctggctccc atcacctacc cgcaggncnn nnggcactgg ccaaggagat tgactcggtg aaatacctgg agtgctcagc nctnacccna gagaggcctg aaaaccgtgt tcgacgangc catccgggcn gtgctgtgcc ctcagcccac gcggcannnn nnnnnnnnnn nnnnnnnnct cctctagggg ttngcanccn nnnnnnncnn nntagatngg tntgntncnn cnnnnnnnna ggnncncgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnggagccct tcacgggacg ctacagcctg tgcc 60 120 180 240 300 360 420 480 494 <210〉 120 <211> 337 <212> DNA <213〉 人類 <220> 98677.doc -81 - 200533758 <223〉 Probe 32772—s一at HG-U95Av2 <220> <221> misc一feature <222〉 （246)..(260) <223> n 為 a，g，c 或 t <220> <221> misc_feature <222〉 （279)..(279) <223〉 n 為 a, g，c 或 t200533758 < 220〉 < 221 > misc—feature < 222〉 380 · .387, 389..392, 398, 402, 405, 407, 409, 410, 412..419 < 223 > n is a, g, c or t < 220 > < 221 > misc-feature < 222〉 423, 424, 426, 429..462 < 223 > n is a, g, c or t < 400 > 119 acagacggac gtcttcctca tctgcttctc cctcgtcagc ccagcctctt atgagaacgt ccgcgccaag tggttcccag aagtgcggca ccactgcccc agcacaccca tcatcctggt gggcaccaag ctggacctgc gggacgacaa ggacaccatc gagaaactga aggagaagaa gctggctccc atcacctacc cgcaggncnn nnggcactgg ccaaggagat tgactcggtg aaatacctgg agtgctcagc nctnacccna gagaggcctg aaaaccgtgt tcgacgangc catccgggcn gtgctgtgcc ctcagcccac gcggcannnn nnnnnnnnnn nnnnnnnnct cctctagggg ttngcanccn nnnnnnncnn nntagatngg tntgntncnn cnnnnnnnna ggnncncgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnggagccct tcacgggacg ctacagcctg tgcc 60 120 180 240 300 360 420 480 494 < 210> 120 < 211 > 337 < 212 > DNA < 213> Human < 220 > 98677.doc -81-200533758 < 223> Probe 32772-s-at HG- U9 5Av2 < 220 > < 221 > misc-feature < 222> (246) .. (260) < 223 > n is a, g, c or t < 220 > < 221 > misc_feature < 222> (279) .. (279) < 223> n is a, g, c or t

<220〉 <221>misc—feature <222〉 （285)..(285) <223> n 為 a，g，c 或 t <220〉 <221> misc_feature <222〉 （287)..(287) <223〉 n 為 a，g，c 或 t< 220〉 < 221 > misc-feature < 222〉 (285) .. (285) < 223 > n is a, g, c or t < 220〉 < 221 > misc_feature < 222〉 ( 287) .. (287) < 223> n is a, g, c or t

<221> misc_feature <222〉 （301)..(301) <223> n 為 a，g，c 或 t <220> <221> misc^feature <222〉 （105)..(105) <223〉n 為 a，g，c 或 t 08677.doc -82- 60 200533758 <400〉 120 ggagacacta tattcaatcg tgctaagctc ctcaatgttg gctttcaaga agccttgaag gactatgact acacctgctt tgtgtttagt gacgtggacc tcatnccaat gaatgaccat aatgcgtaca ggtgtttttc acagccacgg cacatttccg ttgcaatgga taagtttgga ttcagcctac cttatgttca gtattttgga ggtgtctctg ctctaagtaa acaacagttt ctaacnnnnn nnnnnnnnnn taataattat tggggctgng gaggngnaga tgatgacatt nitaacagat tagtttttag aggcatgtct atatctc 120 180 240 300 337< 221 > misc_feature < 222> (301) .. (301) < 223 > n is a, g, c or t < 220 > < 221 > misc ^ feature < 222> (105) .. (105) < 223> n is a, g, c or t 08677.doc -82- 60 200533758 < 400> 120 ggagacacta tattcaatcg tgctaagctc ctcaatgttg gctttcaaga agccttgaag gactatgact acacctgctt tgtgtttagt gacgtggacc tcatnccaat gaatgaccat aatgcgtaca ggtgtttttc acagccacgg cacatttccg ttgcaatgga taagtttgga ttcagcctac cttatgttca gtattttgga ggtgtctctg ctctaagtaa acaacagttt ctaacnnnnn nnnnnnnnnn taataattat tggggctgng gaggngnaga tgatgacatt nitaacagat tagtttttag aggcatgtct atatctc 120 180 240 300 337

<210> 121 <211> 392 <212> DNA <213> 人類 <220〉 <223> Probe 32786_at HG-U95Av2 <220> <221> <222〉 <223〉< 210 > 121 < 211 > 392 < 212 > DNA < 213 > human < 220〉 < 223 > Probe 32786_at HG-U95Av2 < 220 > < 221 > < 222〉 < 223〉

misc_feature (255)..(255) n 為 a，g，c 或 t <220> <221> misc_feature <222〉 （258)..(260) <223> n 為 a，g，c 或 t <220> <221> misc_feature <222> (341)..(341) <223> n 為 a, g，c 或 t 9S677.doc -83- 60 60misc_feature (255) .. (255) n is a, g, c or t < 220 > < 221 > misc_feature < 222> (258) .. (260) < 223 > n is a, g, c Or t < 220 > < 221 > misc_feature < 222 > (341) .. (341) < 223 > n is a, g, c or t 9S677.doc -83- 60 60

200533758 <400〉 121 cgcttggacg gctgggcaca cgcctcccac tggggtccag ggagcaggcg gtgggcaccc accctgggac ctaggggcgc cgcaaaccac actggactcc ggccctccta ccctgcgccc agtccttcca cctcgacgtt tacaagcccc cccttccact tttttttgta tgtttttttt ctgctggaaa cagactcgat tcatattgaa tataatatat ttgtgtattt aacagggagg ggaagagggg gcgantcnnn ggcggagctg gccccgccgc ctggtactca agcccgcggg gacattggga aggggacccc cgccccctgc cctcccctct ntgcaccgta ctgtggaaaa gaaacacgca cttagtctct aaagagttta tt <210> 122 <211> 242 <212> DNA <213>人類 <220〉200533758 < 400> 121 cgcttggacg gctgggcaca cgcctcccac tggggtccag ggagcaggcg gtgggcaccc accctgggac ctaggggcgc cgcaaaccac actggactcc ggccctccta ccctgcgccc agtccttcca cctcgacgtt tacaagcccc cccttccact tttttttgta tgtttttttt ctgctggaaa cagactcgat tcatattgaa tataatatat ttgtgtattt aacagggagg ggaagagggg gcgantcnnn ggcggagctg gccccgccgc ctggtactca agcccgcggg gacattggga aggggacccc cgccccctgc cctcccctct ntgcaccgta ctgtggaaaa gaaacacgca cttagtctct aaagagttta tt < 210 > 122 < 211 > 242 < 212 > DNA < 213 > human < 220>

<223> Probe 32794一g—at HG-U95AW 120 180 240 300 360 392< 223 > Probe 32794-g-at HG-U95AW 120 180 240 300 360 392

<221〉 misc一feature <222〉 （41..58， 189, 195， 197, 201) <223> n 為 a，g，c 或 t <400〉 122 60 120 gactccagat actgcctgag cagccgcctg agggtctcgg nnnnnnnnnn nnnnnnnncc cgcaaccact tccgctgtca agtccagttc tacgggctct cggagaatga cgagtggacc caggataggg ccaaacccgt cacccagatc gtcagcgccg aggcctgggg tagagcagac 08677.doc -84- 180 240 200533758 242 tgtggcttna cctcngngtc ntaccagcaa ggggtcctgt ctgccaccat cctctatgag at <210〉 123 <211> 251 <212〉 DNA <213>人類 <220〉< 221〉 misc-feature < 222〉 (41..58, 189, 195, 197, 201) < 223 > n is a, g, c or t < 400> 122 60 120 gactccagat actgcctgag cagccgcctg agggtctcgg nnnnnnnnnnnn nnnnnnnncc cgcaaccact tccgctgtca agtccagttc tacgggctct cggagaatga cgagtggacc caggataggg ccaaacccgt cacccagatc gtcagcgccg aggcctgggg tagagcagac 08677.doc -84- 180 240 200533758 242 tgtggcttna cctcngngtc ntaccagcaa ggggtcctgt ctgccaccat cctctatgag at < 210> 123 < 211 > 251 < 212> DNA < 213 > human < 220〉

<223> Probe 32818_at HG-U95Av2 <400〉 123 60 120 180 240 251 tagaaccagc cgtattttac atgaagctgt ataattaatt gtcattattt ttgttagcaa agattaaatg tgtcattgga agccatccct ttttttacat ttcatacaac agaaaccaga aaagcaatac tgtttccatt ttaaggatat gattaatatt attaatataa taatgatgat gatgatgatg aaaactaagg atttttcaag agatctttct ttccaaaaca tttctggaca gtacctgatt g <210> 124 <211> 489 <212〉 DNA <213>人類 <220> <223> Probe 32847^at HG-U95Av2 <220〉 <221> misc_feature <222〉 39, 73, 75, 88·.129， 137, 174..176, 309..324, 394..409 <223> n 為 a，g，c 或 t 98677.doc -85- 60 60≪ 223 > Probe 32818_at HG-U95Av2 < 400> 123 60 120 180 240 251 tagaaccagc cgtattttac atgaagctgt ataattaatt gtcattattt ttgttagcaa agattaaatg tgtcattgga agccatccct ttttttacat ttcatacaac agaaaccaga aaagcaatac tgtttccatt ttaaggatat gattaatatt attaatataa taatgatgat gatgatgatg aaaactaagg atttttcaag agatctttct ttccaaaaca tttctggaca gtacctgatt g < 210 > 124 < 211 > 489 < 212> DNA < 213 > human < 220 > < 223 > Probe 32847 ^ at HG-U95Av2 < 220> < 221 > misc_feature < 222〉 39, 73, 75, 88 · .129, 137, 174..176, 309..324, 394..409 < 223 > n is a, g, c or t 98677.doc -85- 60 60

200533758 <400〉 124 tccaaggacc ggatgaagaa gtacatggca agaaggaant ggcagaaaac gggcaatgct gtgagagcca ttngnagact gtcctctnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna gggtcancca accagcccgc tcaatgcaga aaaactagaa tctnnngaag atgtgtccca agctttcctt gaggctgttg ctgaggaaaa gcctcatgta aaaccctatt tctctaagac cattcgcgat ttagaagttg tggagggaag tgctgctaga tttgactgca agattgaann nnnnnnnnnn nnnnaggttg tctggttcaa agatgaccag tcaatcaggg agtcccgcca cttccagata gactacgatg aggnnnnnnn nnnnnnnnna attattagtg atgtttgcgg ggatgacgat gccaagtaca cctgcaaggc tgtcaacagt cttggagaag ccacctgca <210> 125 <211> 602 <212〉 DNA <213>人類 <220〉 <223> Probe 3294七at HG-U95Av2 <220〉 <221> misc^feature <222〉 （26)·.(46) <223〉n 為 a，g，c 或 t <220> <221> misc—feature 120 180 240 300 360 420 480 489 98677.doc -86 -200533758 < 400> 124 tccaaggacc ggatgaagaa gtacatggca agaaggaant ggcagaaaac gggcaatgct gtgagagcca ttngnagact gtcctctnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna gggtcancca accagcccgc tcaatgcaga aaaactagaa tctnnngaag atgtgtccca agctttcctt gaggctgttg ctgaggaaaa gcctcatgta aaaccctatt tctctaagac cattcgcgat ttagaagttg tggagggaag tgctgctaga tttgactgca agattgaann nnnnnnnnnn nnnnaggttg tctggttcaa agatgaccag tcaatcaggg agtcccgcca cttccagata gactacgatg aggnnnnnnn nnnnnnnnna attattagtg atgtttgcgg ggatgacgat gccaagtaca cctgcaaggc tgtcaacagt cttggagaag ccacctgca < 210 > 125 < 211 > 602 < 212〉 DNA < 213 > human < 220〉 < 223 > Probe 3294 seven at HG-U95Av2 < 220> < 221 > mis feature < 222〉 (26) ·. (46) < 223〉 n is a, g, c or t < 220 > < 221 > misc—feature 120 180 240 300 360 420 480 489 98677.doc -86 -

200533758 <222〉 （141)..(155) <223> η 為 a，g，c 或 t <220> <221〉mi sc—feature <222〉 （190)..(205) <223〉n 為 a，g，c 或 t <400> 125 accagaccag ccaagaaact gaaacnnnnn nnnnnnnnnn nnnnnngaga aacctacaca gatgatcttc caccacctcc tgtgccgcca cctgctataa agtcacctac tgcccaatcc aagacacagc tggaagtacg nnnnnnnnnn nnnnnaaaac tcccttctat ggatgcaaga acagacagan nnnnnnnnnn nnnnngaagc agttacaagg ggagagaagt gttggatgga agacaggttg ttgacatgcg aacaaatcca ggtgatccca gagaagcaca ggaacagcaa aatgacggga aaggacgtgg aaacaaggca gcaaaacgag accttccacc agcaaagact catctcatcc aagaggatat tctaccttat tgtagaccta cttttccaac atcaaataat cccagagatc ccagttcctc aagctcaatg tcatcaagag gatcaggaag cagacaaaga gaacaagcaa atgtaggtcg aagaaatatt gcagaaatgc aggtacttgg aggatatgaa agaggagaag ataataatga agaattagag gaaactgaaa gctgaagaca accaagaggc tt <210> 126 <211> 183 <212> DNA <213>人類 60 120 180 240 300 360 420 480 540 600 602 98677.doc -87- 200533758 <220〉 <223> Probe 33102_at HG-U95Av2 <400〉 126 atatttttgg acaagaatct gattcatttg caa agtcccattg atagcattag gaattttatt tttcagtggg tatacactgg cacagtataa cattaacaga cacataattt aatttcctca atgctttaaa tttaaaaagt cctgaagtaa aacttctaag tttaagaaaa ctttgtttgc200533758 < 222〉 (141) .. (155) < 223 > η is a, g, c or t < 220 > < 221〉 mi sc-feature < 222> (190) .. (205) aatgacggga aaggacgtgg 125 accagaccag ccaagaaact gaaacnnnnn nnnnnnnnnn nnnnnngaga aacctacaca gatgatcttc caccacctcc tgtgccgcca cctgctataa agtcacctac tgcccaatcc aagacacagc tggaagtacg nnnnnnnnnn nnnnnaaaac tcccttctat ggatgcaaga acagacagan nnnnnnnnnn nnnnngaagc agttacaagg ggagagaagt gttggatgga agacaggttg ttgacatgcg aacaaatcca ggtgatccca gagaagcaca ggaacagcaa; < 223> n is a, g, c or t < 400 & gt aaacaaggca gcaaaacgag accttccacc agcaaagact catctcatcc aagaggatat tctaccttat tgtagaccta cttttccaac atcaaataat cccagagatc ccagttcctc aagctcaatg tcatcaagag gatcaggaag cagacaaaga gaacaagcaa atgtaggtcg aagaaatatt gcagaaatgc aggtacttgg aggatatgaa agaggagaag ataataatga agaattagag gaaactgaaa gctgaagaca accaagaggc tt < 210 > 126 < 211 > 183 < 212 > DNA < 213 > human 60 120 180 240 300 360 420 480 540 600 602 98677.doc -87- 200533758 < 220〉 < 223 & g t; Probe 33102_at HG-U95Av2 < 400〉 126 atatttttgg acaagaatct gattcatttg caa agtcccattg atagcattag gaattttatt tttcagtggg tatacactgg cacagtataa cattaacaga cacataattt aatttcctca atgctttaaa tttaaaagt actagat cctga

<210> 127 <211> 485 <212〉 DNA <213>人類 <220〉 <223>Probe 33103_s—atHG-U95Av2< 210 > 127 < 211>

<400> 127 tctcacagaa agaagaaaac agtaaatggc gttaagcaca cgaagaagtc attccgcact aaagtctttt aagttgatca ggagaacttg catgagctgt aaggatgata agtacaacca ctgtcacctg ccttcttttc tataattatt ttaatatgca aagagtataa tttccaagag tgcatgatgt tagaaaacat aaggctcccc tgaaaaagaa attataacaa atggtagatc gaggacaatc cttcatctcc tgaagatgag cgagattact ttcaaaatcg caaaaaaaag tgtgacattg agattggggg gaacgtaaac atggaagtgc cttgctaagc attaagtctc ccatccaaga gagaaagttg cacatctaaa atgtagcaaa aacaaggcct ctgtcatggt gagtgagtag cagagaaaat aaaagaagaa aggcctaaat taccacattt ctggacttta 98677.doc -88 - 485 200533758 agaac <210> 128 <211> 453 <212〉 DNA <213>人類 <220〉 <223〉 Probe 33113—at HG-U95Av2≪ 400 > 127 tctcacagaa agaagaaaac agtaaatggc gttaagcaca cgaagaagtc attccgcact aaagtctttt aagttgatca ggagaacttg catgagctgt aaggatgata agtacaacca ctgtcacctg ccttcttttc tataattatt ttaatatgca aagagtataa tttccaagag tgcatgatgt tagaaaacat aaggctcccc tgaaaaagaa attataacaa atggtagatc gaggacaatc cttcatctcc tgaagatgag cgagattact ttcaaaatcg caaaaaaaag tgtgacattg agattggggg gaacgtaaac atggaagtgc cttgctaagc attaagtctc ccatccaaga gagaaagttg cacatctaaa atgtagcaaa aacaaggcct ctgtcatggt gagtgagtag cagagaaaat aaaagaagaa aggcctaaat taccacattt ctggacttta 98677.doc -88-485 200533758 agaac < 210 > 128 < 211 > 453 < 212〉 DNA < 213 > human < 220〉 < 223〉 Probe 33113-at HG-U95Av2

<220〉 <221> misc^feature <222> 61..101, 142, 145, 197, 208, 213, 242, 243, 249..253 <223> n 為 a, g, c 或 t <220> <221> misc一feature <222> 255..310, 399..401 <223〉n 為 a, g，c 或 t< 220> < 221 > misc ^ feature < 222 > 61..101, 142, 145, 197, 208, 213, 242, 243, 249..253 < 223 > n is a, g, c or t < 220 > < 221 > misc-feature < 222 > 255..310, 399..401 < 223> n is a, g, c or t

<400〉 128 tttctccagt nnnnnnnnnn ttagttggtt cattttttta anngattann nnnnnnnnnn agggtgtgga gctcaactgt nnnnnnnnnn gcatgaactt actatgncat nnnannnnnn tggctgtccc atgtcgtcag tagatattaa nnnnnnnnnn cngangggca ttgagtanca nnnnnnnnnn ccccgccgcc tggcaaacat tcttggcaaa nnnnnnnnnn gatattactg ganctaattt nnnnnnnnnn ccccccaccc ttcacagann ctgcttaatc nagtgaaagg cacaaactgc ttaaaatatg nnnnnnnnnn ccatatgtac nttattttgt ttgtggattt aaaaattgca catctcgctt ctaaactgga nnnnnnnnnn agatgataat ttctgtcttc 60 120 180 240 300 360 98677.doc -89- 420 200533758 aacatttttg acactgtgct aatagttata ttc <210〉 129 <211> 514 <212〉 DNA <213>人類 <220〉 <223> Probe 33130—at HG-U95Av2 <220〉 <221> misc_feature <222> (143)..(159) <223> n 為 a，g，c 或 t <220〉 <221> misc_feature <222〉 （316)..(333) <223> n 為 a，g，c 或 t <220〉 misc一feature (78)..(78) n 為 a，g，c 或 t 453≪ 400> 128 tttctccagt nnnnnnnnnn ttagttggtt cattttttta anngattann nnnnnnnnnn agggtgtgga gctcaactgt nnnnnnnnnn gcatgaactt actatgncat nnnannnnnn tggctgtccc atgtcgtcag tagatattaa nnnnnnnnnn cngangggca ttgagtanca nnnnnnnnnn ccccgccgcc tggcaaacat tcttggcaaa nnnnnnnnnn gatattactg ganctaattt nnnnnnnnnn ccccccaccc ttcacagann ctgcttaatc nagtgaaagg cacaaactgc ttaaaatatg nnnnnnnnnn ccatatgtac nttattttgt ttgtggattt aaaaattgca catctcgctt ctaaactgga nnnnnnnnnn agatgataat ttctgtcttc 60 120 180 240 300 360 98677.doc -89- 420 200533758 aacatttttg acactgtgct aatagttata ttc < 210〉 129 < 211 > 514 < 212〉 DNA < 213 > human < 220〉 < 223 > Probe 33130-at HG-U95Av2 < 220> < 221 > misc_feature < 222 > (143) .. (159) < 223 > n is a, g, c or t < 220〉 < 221 > misc_feature < 222〉 (316) .. (333) < 223 > n is a, g, c or t < 220〉 misc-feature (78) .. (78) n is a, g, c or t 453

<221> <222〉 <223〉 <400〉 129 cttgtaagcc cagcccagct tggcagacca ccaaagtttt acttgtttgg ccgctgcnta ttagttgctg tctggtttta ttatgatttg tctttgcctc agnnnnnnnn atttaaagga tgtcttatca acttagtcat nnnnnnnnnt caaggctaca gggaaaaggt gtgcaattcg gtgctcagaa tatattcagc gcccagctgc cgttgcagag gagcacctgc tttttgagat 60 120 180 240 98677.doc -90- 200533758 gaccaaagct gcactccagt gatacaatcg ctgaactata ttttttaaaa agttagggtc tttttnnnnn ctgtttagtt tcttgacaaa agatttgctt tccttgatgt nnnnnnnnnn actagatgaa tattattcaa gcaatgacct agctaagctg nnnttctacc caaatccaca acttgaatgt tata cttcagtgat tctctatgtg gaatgggtaa aaatatatac cttcacattt cctgagtgat agagtagaat agtatgtata <210〉 130 <211> 549 W <212> DNA <213>人類 <220> <223> Probe 33235_at HG-U95Av2 <220〉 <221> misc_feature <222> 26..40, 262, 273 <223〉n 為 a, g，c 或 t≪ 221 > < 222> < 223> < 400> 129 cttgtaagcc cagcccagct tggcagacca ccaaagtttt acttgtttgg ccgctgcnta ttagttgctg tctggtttta ttatgatttg tctttgcctc agnnnnnnnn atttaaagga tgtcttatca acttagtcat nnnnnnnnnt caaggctaca gggaaaaggt gtgcaattcg gtgctcagaa tatattcagc gcccagctgc cgttgcagag gagcacctgc tttttgagat 60 120 180 240 98677.doc -90 - 200533758 gaccaaagct gcactccagt gatacaatcg ctgaactata ttttttaaaa agttagggtc tttttnnnnn ctgtttagtt tcttgacaaa agatttgctt tccttgatgt nnnnnnnnnn actagatgaa tattattcaa gcaatgacct agctaagctg nnnttctacc caaatccaca acttgaatgt tata cttcagtgat tctctatgtg gaatgggtaa aaatatatac cttcacattt cctgagtgat agagtagaat agtatgtata < 210> 130 < 211 > 549 W < 212 > DNA < 213 > Human < 220 > < 223 > Probe 33235_at HG-U95Av2 < 220〉 < 221 > misc_feature < 222 > 26..40, 262, 273 < 223> n is a, g, c or t

<400〉 130 gtgtcacaaa atttatgcac gtgaaacatc taagaaaatt acagaatttc tgtgaaacat gtcaataggt atagaattgt aatatatgta gctaatcttt ctgcaataca ttgtctgtat ccttannnnn caccctgact gctggatgag ccctgccatt tncccagtag acattttata nnnnnnnnnn ttgaagcctc tgactagttt ttgagaaaca gtnccaccta ttttgtacat ctaagggaaa aaacatggat cccttgtata cagtccaaac gtttacaact tttgatgtaa tccgaactga caaatctgtt atatgtgatc atgagcataa taaactagtt catatcatgt 98677.doc -91 - 200533758 aaataggcag aacaataagt gttcctctag gtctaaatt aaacagtgaa acttggtgtc cttgtaaacc ataaatcatc aatggactta agcttgcata tgaaaagttt actggatgat tatttttttg tgtagtcttt gtattttcta caaatgtgca gtaaagcccc ttggtttatt ccctgtatct≪ 400> 130 gtgtcacaaa atttatgcac gtgaaacatc taagaaaatt acagaatttc tgtgaaacat gtcaataggt atagaattgt aatatatgta gctaatcttt ctgcaataca ttgtctgtat ccttannnnn caccctgact gctggatgag ccctgccatt tncccagtag acattttata nnnnnnnnnn ttgaagcctc tgactagttt ttgagaaaca gtnccaccta ttttgtacat ctaagggaaa aaacatggat cccttgtata cagtccaaac gtttacaact tttgatgtaa tccgaactga caaatctgtt atatgtgatc atgagcataa taaactagtt catatcatgt 98677.doc -91 - 200533758 aaataggcag aacaataagt gttcctctag gtctaaatt aaacagtgaa acttggtgtc cttgtaaacc ataaatcatc aatggactta agcttgcata tgaaaagttt actggatgat tatttttttg tgtagtcttt gtattttcta caaatgtgca gtaaagcccc ttggtttatt ccctgtat

<210〉 131 <211> 539 <212〉 DNA <213>人類 <220〉 <223> Probe 33236一at HG-U95Av2 <220〉 <221> misc_feature <222〉 （31)..(46) <223> n 為 a，g，c 或 t <220〉 <221〉 <222〉 <223> misc_feature (140)..(234) n 為 a，g，c 或 t <400> 131 tgagcaacag atcgggtcaa gttctgcgaa nnnnnnnnnn tgcagaggtg caacagcttg ggagatggtn nnnnnnnnnn aaacgggagc gaccatgagt nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn accaaccacg nnnnnnnnnn nnnnnnnnnn nnnnnnggga gcccgtggag nnnnnnnnnn nnnnnnnnnn ggctgttgct gtgatcatca nnnnnnnnnn nnnntggaaa 98677.doc -92- 200533758 aggccaaggt cttttgcgat gttagaagca gaccctcgtg ggcaaaagta tgaagtcggt taggagatac gctgtggggg ccctgtctca tgatctaatt gtggccacgg caaaaaaaag tcccagtgga ggcgttctct gaaacaagac cgcttggaat cgacagcctg gatgagcctc agatcctttc tgaaggatca cctggttgtt aagcagccac ccccatgcct ctctgtttcc ataaacagcc gctggatgct aaaatcctgt ccagcagcct ctctctcgct atctgcccc< 210> 131 < 211 > 539 < 212> DNA < 213 > Human < 220〉 < 223 > Probe 33236-at HG-U95Av2 < 220> < 221 > misc_feature < 222〉 (31 ) .. (46) < 223 > n is a, g, c or t < 220〉 < 221〉 < 222〉 < 223 > misc_feature (140) .. (234) n is a, g, c or t < 400 > 131 tgagcaacag atcgggtcaa gttctgcgaa nnnnnnnnnn tgcagaggtg caacagcttg ggagatggtn nnnnnnnnnn aaacgggagc gaccatgagt nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn accaaccacg nnnnnnnnnn nnnnnnnnnn nnnnnnggga gcccgtggag nnnnnnnnnn nnnnnnnnnn ggctgttgct gtgatcatca nnnnnnnnnn nnnntggaaa 98677.doc -92- 200533758 aggccaaggt cttttgcgat gttagaagca gaccctcgtg ggcaaaagta tgaagtcggt taggagatac gctgtggggg ccctgtctca tgatctaatt gtggccacgg caaaaaaaag tcccagtgga ggcgttctct gaaacaagac cgcttggaat cgacagcctg gatgagcctc agatcctttc tgaaggatca cctggttgtt aagcagccac ccccatgcct ctctgtttcc ataaacagcc gctggatgg ctctcc actat

<210> 132 <211> 563 <212〉 DNA <213>人類 <220〉 <223> Probe 33243_at HG-U95Av2 <220> <221> mi sc一feature <222> 123..137, 235, 244..260, 444, 488..511, 520..534 <223> n 為 a，g，c 或 t <400〉 132 tgcttctgga attgagttct ccttttaagt accaatgata cttaaatttc tcagaaatgt aatggtgtgt cattgccttg aaatgcttgc ttagggcttc ttttatgtta tcttaaaaag tgnnnnnnnn nnnnnnnttt tttacatcca tttcacatgt aagagacaaa aaagtctaga ttggtcttga tattgagata ataaaaagta agtagcatta agaaaggtaa caatncttea ttcnnnnnnn nnnnnnnnnn tgaaacaatt taggggaatg aggggcaaaa ggggagaaat actgctaaag aacatgagca taaaaatgcg tgcgtttcag tgtttaagaa ggettgataa 98677.doc -93 - 200533758 agaatgtcac accaaagaat taaataannn ctatgtcctc ttttttattt atttgtattt nnnnnnnnnn taggaaatga aactgataag caancagttt nnnnnnnnnn cag atttttgtta gtgtggtgtt ntaaaaaagn ttttttactt tctatataat nnnnnnnnnn tgataagtaa tttctgtgta nnnnnnccag< 210 > 132 < 211 > 563 < 212> DNA < 213 > Human < 220> < 223 > Probe 33243_at HG-U95Av2 < 220 > < 221 > mi sc-feature < 222 > 123 ..137, 235, 244..260, 444, 488..511, 520..534 < 223 > n is a, g, c or t < 400> 132 tgcttctgga attgagttct ccttttaagt accaatgata cttaaatttc tcagaaatgt aatggtgt agtgcttggttggt ttttatgtta tcttaaaaag tgnnnnnnnn nnnnnnnttt tttacatcca tttcacatgt aagagacaaa aaagtctaga ttggtcttga tattgagata ataaaaagta agtagcatta agaaaggtaa caatncttea ttcnnnnnnn nnnnnnnnnn tgaaacaatt taggggaatg aggggcaaaa ggggagaaat actgctaaag aacatgagca taaaaatgcg tgcgtttcag tgtttaagaa ggettgataa 98677.doc -93 - 200533758 agaatgtcac accaaagaat taaataannn ctatgtcctc ttttttattt atttgtattt nnnnnnnnnn taggaaatga aactgataag caancagttt nnnnnnnnnn cag atttttgtta gtgtggtgtt ntaaaaaagn ttttttactt tctatataat nnnnnnnnnn tgataagtaa tttctgtgta nnnnnnccag

<210〉 133 <211> 428 <212〉 DNA <213>人類 <220> <223> Probe 33249—at HG-U95Av2 <220〉 <221> misc_feature <222〉 44, 48, 49, 52, 94..135， 188·.203, 343 <223> n 為 a，g，c 或 t <400> 133 cacagcatgc agactgggag ttgctagcaa acaaatggct tacntacnna angcagcttt tagttcagac ttagttttta taaaatggga attnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncaget ttttgtatta acaaagttac tggctctttg tgtgtctcca ggtaactnnn nnnnnnnnnn nnncaaagcc atattetaaa ttcactgttg aatgcctgtc ccagtccaaa ttgtctgtct getettattt ttgtaccata ttgctcttaa aaatcttggt ttggtacagt tcataattea ccaaaagttc atataattta aanaaacact aaattagttt aaaatgaagc aatttatatc tttatgcaaa aacatatgtc tgtetttgea aaggactgta 98677.doc -94- 428 200533758 agcagatt <210> 134 <211> 451 <212> DNA <213>人類 <220〉 <223〉 Probe 33281—at HG-U95Av2 <220〉< 210> 133 < 211 > 428 < 212> DNA < 213 > Human < 220 > < 223 > Probe 33249-at HG-U95Av2 < 220> < 221 > misc_feature < 222〉 44, 48, 49, 52, 94..135, 188 · .203, 343 < 223 > n is a, g, c or t < 400 > 133 cacagcatgc agactgggag ttgctagcaa acaaatggct tacntacnnagetnnn nnn nnn taaaat acaaagttac tggctctttg tgtgtctcca ggtaactnnn nnnnnnnnnn nnncaaagcc atattetaaa ttcactgttg aatgcctgtc ccagtccaaa ttgtctgtct getettattt ttgtaccata ttgctcttaa aaatcttggt ttggtacagt tcataattea ccaaaagttc atataattta aanaaacact aaattagttt aaaatgaagc aatttatatc tttatgcaaa aacatatgtc tgtetttgea aaggactgta 98677.doc -94- 428 200533758 agcagatt < 210 > 134 < 211 > 451 < 212 > DNA < 213 > Humans < 220〉 < 223〉 Probe 33281-at HG-U95Av2 < 220>

<221> misc—feature <222〉 31， 86, 91， 109， 112， 113， 179, 242, 243, 250, 258, 260 <223〉n 為 a，g，c 或 t <220〉 <221> misc一feature <222〉 262, 263, 266, 267, 272, 281， 282, 285, 288..291， 293··332, 374 <223> n is a, g, c or t< 221 > misc—feature < 222〉 31, 86, 91, 109, 112, 113, 179, 242, 243, 250, 258, 260 < 223> n is a, g, c or t < 220 〉 ≪ 221 > misc-feature < 222〉 262, 263, 266, 267, 272, 281, 282, 285, 288..291, 293 · 332, 374 < 223 > n is a, g, c or t

<400〉 134 acccacagga aggtactgct cccactccct gggtttcccc tnncatgttn nnnnnnnnnn tgagaaaatg aagagtgtgg cctccatgcc ctggtttata agggcagtag aacacagntn nnnnnnnnnn ggtngccaag cagcaactgc catggntggg ggacttcact gtcaaacgac tnnccnntcc nnnnnnnnnn gccagtgcca ntggctgacc ncgtggggag ccctagccaa ctcatcacag cntgtgatίt nnctatgctt gtgtcttggg tttctatctt aagaagctnt caggagagga tcttccttcc nnganggnnn ggtctgactg gcccctttgg ctctaggctc cnnacgcctt ggcctcctng tcttcaagcg ncnnnnnnnn agcctaaagt ctctccctca ctctctgagg ctccagctgg tcctgggaca t 60 120 180 240 300 360 420 451 98677.doc -95-≪ 400> 134 acccacagga aggtactgct cccactccct gggtttcccc tnncatgttn nnnnnnnnnn tgagaaaatg aagagtgtgg cctccatgcc ctggtttata agggcagtag aacacagntn nnnnnnnnnn ggtngccaag cagcaactgc catggntggg ggacttcact gtcaaacgac tnnccnntcc nnnnnnnnnn gccagtgcca ntggctgacc ncgtggggag ccctagccaa ctcatcacag cntgtgatίt nnctatgctt gtgtcttggg tttctatctt aagaagctnt caggagagga tcttccttcc nnganggnnn ggtctgactg gcccctttgg ctctaggctc cnnacgcctt ggcctcctng tcttcaagcg ncnnnnnnnn agcctaaagt ctctccctca ctctctgagg ctccagctgg tcctgggaca t 60 120 180 240 300 360 420 451 98677.doc -95-

200533758 <210〉 135 <211〉 593 <212〉 DNA <213>人類 <220〉 <223> Probe 33295_at HG-U95Av2 <220〉 <221> mi sc—feature <222〉 108, 158, 229, 247, 349·.363, 370··455 <223> n 為 a，g，c 或 t <400〉 135 cagactgggt gcaggccagg tcccaggcct caccctgggg ctcactgtgg gaatttgggg agtggctgcc ctactgacac tgcctgtcac cctggccagt ggtgcttntg gtggactctg caccctgata tacagcacgg agctgaaggc tttgcagncc acacacactg tagcctgtct tgccatcttt gtcttgttgc cattgggttt gtttggagcc aaggggctna agaaggcatt gggtatnggg ccaggcccct ggatgaatat cctgtgggcc tggtttattt tctggtggcc tcatggggtg gttctaggac tggatttcct ggtgaggtcc aagctgttnn nnnnnnnnnn nnntctggcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntctgc caccaggcca cccgcaccct cttgccctct ctgcccctcc ctgaaggatg gtcttctcat ctggacaccc ttggaagcaa atcctagttc tcttcccacc tgtcaacctg aattaaagtc tacactgcct ttg 60 120 180 240 300 360 420 480 540 98677.doc -96- 593 200533758 <210〉 136 <211〉 498 <212> DNA <213>人類 <220〉 <223〉 Probe 33304—at HG-U95Av2 <220> <221> misc^feature <222〉 41， 85, 89, 96， 164..180, 216·.231， 330..361 <223〉n 為 a，g，c 或 t200533758 < 210〉 135 < 211〉 593 < 212〉 DNA < 213 > Human < 220〉 < 223 > Probe 33295_at HG-U95Av2 < 220> < 221 > mi sc--feature < 222〉 108, 158, 229, 247, 349 · .363, 370 ·· 455 < 223 > n is a, g, c or t < 400> 135 cagactgggt gcaggccagg tcccaggcct caccctgggg ctcactgtgg gaatttgggg aggggctgcc ctactgacca cggctggctggctggtcg tttgcagncc acacacactg tagcctgtct tgccatcttt gtcttgttgc cattgggttt gtttggagcc aaggggctna agaaggcatt gggtatnggg ccaggcccct ggatgaatat cctgtgggcc tggtttattt tctggtggcc tcatggggtg gttctaggac tggatttcct ggtgaggtcc aagctgttnn nnnnnnnnnn nnntctggcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntctgc caccaggcca cccgcaccct cttgccctct ctgcccctcc ctgaaggatg gtcttctcat ctggacaccc ttggaagcaa atcctagttc tcttcccacc tgtcaacctg aattaaagtc tacactgcct ttg 60 120 180 240 300 360 420 480 540 98677.doc -96- 593 200533758 < 210〉 136 < 21 1> 498 < 212 > DNA < 213 > human < 220> < 223〉 Probe 33304-at HG-U95Av2 < 220 > < 221 > misc ^ feature < 222> 41, 85, 89, 96 , 164..180, 216 · .231, 330..361 < 223> n is a, g, c or t

<400〉 136 gttcatccgg tcagcacatg tgaaaggcaa acatgagcgg agctggacca gcatccagaa nctatcaaat actgaagccc aactaccttg cctgagggag gtgggggcca gctggtggtg ctacacaatc ctgcaggcgt cagcctgctt ctcccagaga catccagccc cttttgga agatcaccga caccntttng ggtcatgacc tacgacacgt gtctccctgc ggacacagcn atccgagccc gttccgcagg ttacagaacc ccgtgnccag tgaagcacga ccactnnnnn gggtgctgag nnnnnnnnnn gccgagggct gactagaggc ngggtcagcg gctagagatc cttnnnnnnn nnnnnnnnnn tgagcgcctc nnnnnnnnnn gccccgcctg tttcggcttt gggtcacccc ctgcagctcc nnnnnnnnnn ngtgaggcca ctgcacaaga nnnnnnnnnn gctgtgtcag ttgggacagc 60 120 180 240 300 360 420 480 498 <210> 137 <211〉 503 <212〉 DNA <213〉人類 98677.doc -97- 200533758 <220> <223〉 Probe 33331—at HG-U95Av2 <220〉 <221> misc_feature <222〉 27, 74, 218, 242, 243, 310, 320·.322, 459, 462..464 <223> n 為 a，g，c 或 t≪ 400> 136 gttcatccgg tcagcacatg tgaaaggcaa acatgagcgg agctggacca gcatccagaa nctatcaaat actgaagccc aactaccttg cctgagggag gtgggggcca gctggtggtg ctacacaatc ctgcaggcgt cagcctgctt ctcccagaga catccagccc cttttgga agatcaccga caccntttng ggtcatgacc tacgacacgt gtctccctgc ggacacagcn atccgagccc gttccgcagg ttacagaacc ccgtgnccag tgaagcacga ccactnnnnn gggtgctgag nnnnnnnnnn gccgagggct gactagaggc ngggtcagcg gctagagatc cttnnnnnnn nnnnnnnnnn tgagcgcctc nnnnnnnnnn gccccgcctg tttcggcttt gggtcacccc ctgcagctcc nnnnnnnnnn ngtgaggcca ctgcacaaga nnnnnnnnnn gctgtgtcag ttgggacagc 60 120 180 240 300 360 420 480 498 < 210 > 137 < 211> 503 < 212〉 DNA < 213〉 human 98677.doc -97- 200533758 < 220 > < 223〉 Probe 33331—at HG-U95Av2 < 220〉 < 221 > misc_feature < 222〉 27, 74, 218, 242, 243, 310, 320 · .322, 459, 462..464 < 223 > n is a, g, c or t

<400〉 137 gaaggaccca ttaagcaccc gggctcacca tggttttaaa anngcacagc agaaagggan tcctggggtt ttcactactg ttgcaacctg tgtcccagga ggtngccctc ggacctcaac gtaaatgttt cctgtaactg ttgtcctaan tgcggggaca ctcactgctc ataccttgaa accgcgntgc cgaggcctgg gggcaaagtt ttctaaagaa cacgtgcctt nngtttgagg gggacagaac actttctgat aag gccacctgca cggaatggtg gtgcacacta agctgtgntc ctgtcattgg ccttacagtt tacaggagtc cactctgana ctcacccccc gtgcccacgg aaatatcaaa ttctgttgac gaatgaaata ttgtatctac atgggaaaga cnnntttttt tcacattctc ggttgggcaa tcaaggtgct ccagacgaat aattattacg atttttcccc aaattctggc tttttttttt 60 120 180 240 300 360 420 480 503 <210〉 138 <211〉 464 <212〉 DNA <213〉人類 <220> <223〉 Probe 33371一s一at HG-U95Av2 98677.doc -98-≪ 400> 137 gaaggaccca ttaagcaccc gggctcacca tggttttaaa anngcacagc agaaagggan tcctggggtt ttcactactg ttgcaacctg tgtcccagga ggtngccctc ggacctcaac gtaaatgttt cctgtaactg ttgtcctaan tgcggggaca ctcactgctc ataccttgaa accgcgntgc cgaggcctgg gggcaaagtt ttctaaagaa cacgtgcctt nngtttgagg gggacagaac actttctgat aag gccacctgca cggaatggtg gtgcacacta agctgtgntc ctgtcattgg ccttacagtt tacaggagtc cactctgana ctcacccccc gtgcccacgg aaatatcaaa ttctgttgac gaatgaaata ttgtatctac atgggaaaga cnnntttttt tcacattctc ggttgggcaa tcaaggtgct ccagacgaat aattattacg atttttcccc aaattctggc tttttttttt 60 120 180 240 300 360 420 480 503 < 210〉 138 < 211> 464 < 212〉 DNA < 213〉 Human < 220 > < 223〉 Probe 33371-s-at HG -U95Av2 98677.doc -98-

200533758 <220> <221> misc一feature <222〉 206, 236, 247, 359, 370·.372, 414, 432..434 <223〉η 為 a，g，c 或 t <400> 138 cgacctctca gatattaggg aggttcccct gaaggatgct aaggaatacg ctgaatccat aggtgccatc gtggttgaga caagtgcaaa aaatgctatt aatatcgaag agctctttca aggaatcagc cgccagatcc cacccttgga cccccatgaa aatggaaaca atggaacaat caaagttgag aagccaacca tgcaanccag ccgccggtgc tgttgaccca agggcngtgg tccacgntac ttgaagaagc cagagcccac atcctgtgca ctgctgaagg accctacgct cggtggcctg gcacctcact ttgagaagag tgagcacact ggctttgcat cctggaagnc ctgcaggggn nngggcagga aatgtacctg aaaaggattt tagaaaaccc tggnaaaccc accacaccac cnnnacaaaa tggcctttag tgtatgaaat gcac <210〉 139 <211> 69 <212〉 DNA <213> 人類 <220〉 <223> Probe 33410_at HG-U95Av2 <400> 139 agtgactgtg tttccctcaa agactgtagc tcagtattcg ggagtacctt ggtggatcat cctagtggc 60 120 180 240 300 360 420 464 60 98677.doc -99- 69 200533758 <210> 140 <211> 133 <212> DNA <213> 人類 <220> <223〉 Probe 33411一g—at HG-U95Av2 <400〉 140 ctgtagcgtg aacgtgaact gtgtgaacat cagatgcccg ctgcgggggc tggacagcaa ggcgtctctt attttgcgct cgaggttatg gaacagcaca tttctagagg aatattccaa200533758 < 220 > < 221 > misc-feature < 222〉 206, 236, 247, 359, 370 · .372, 414, 432..434 < 223> η is a, g, c or t < 400 > 138 cgacctctca gatattaggg aggttcccct gaaggatgct aaggaatacg ctgaatccat aggtgccatc gtggttgaga caagtgcaaa aaatgctatt aatatcgaag agctctttca aggaatcagc cgccagatcc cacccttgga cccccatgaa aatggaaaca atggaacaat caaagttgag aagccaacca tgcaanccag ccgccggtgc tgttgaccca agggcngtgg tccacgntac ttgaagaagc cagagcccac atcctgtgca ctgctgaagg accctacgct cggtggcctg gcacctcact ttgagaagag tgagcacact ggctttgcat cctggaagnc ctgcaggggn nngggcagga aatgtacctg aaaaggattt tagaaaaccc tggnaaaccc accacaccac cnnnacaaaa tggcctttag tgtatgaaat gcac < 210> 139 < 211 > 69 < 212> DNA < 213 > human < 220> < 223 > Probe 33410_at HG-U95Av2 < 400 > 139 agtgactgtg tttccctcaa agactgtagc tcagtattcg ggagt 120 cc ggtggcat 60 360 420 464 60 98677.doc -99- 69 200533758 < 210 > 140 < 211 > 133 < 212 > DNA < 213 > human < 220 > < 223〉 Probe 33411-g-at HG-U95Av2 < 400> 140 ctgtagcgtg aacgtgaact gtgtgaacat cagatgcccg ctgcgggggc tggacagcaa ggcgtctctt attttgcgct cgaggttatg agagacaca

actgaactac ttg <210> 141 <211〉 444 <212> DNA <213>人類 <220〉 <223> Probe 33439—at HG-U95Av2 <220〉 <221〉 misc_feature <222〉 27, 29, 78..118, 131..147， 159， 160, 379..404, 419 <223〉 n 為 a，g，c 或 t <400> 141 gaccaggtgc cttgccgcag agaaaancna ccaaagtctc ctgttcgctc ataaagaagt ttttgggatg ggagagannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntt tttacagagg nnnnnnnnnn nnnnnnncaa cacaaaacnn cttccccttt ttaaaatgat ttctgttcta atgccataga tcaaaggcct cagaaaccat tgtgtgtttc ctctttgaag 98677.doc -100- 200533758 caatgacaag cactttactt tcacggtggt ttttgttttt tcttattgct gtggaacctc ttttggagga cgttaaaggc gtgttttact tgttttttta agagtgtgtg atgtgtgttt tgtagatttc ttgacagtnn nnnnnnnnnn nnnnnnnnnn nnnngcctat ttaaagacnc tacgtgatct gattgagatg tacaactgaactac ttg < 210 > 141 < 211> 444 < 212 > DNA < 213 > human < 220〉 < 223 > Probe 33439—at HG-U95Av2 < 220〉 < 221〉 misc_feature < 222〉 27, 29, 78..118, 131..147, 159, 160, 379..404, 419 < 223> n is a, g, c or t < 400 > 141 gaccaggtgc cttgccgcag agaaaancna ccaaagtctc ctgttcgctc ataaagaagt ttttgggnng nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntt tttacagagg nnnnnnnnnn nnnnnnncaa cacaaaacnn cttccccttt ttaaaatgat ttctgttcta atgccataga tcaaaggcct cagaaaccat tgtgtgtttc ctctttgaag 98677.doc -100- 200533758 caatgacaag cactttactt tcacggtggt ttttgttttt tcttattgct gtggaacctc ttttggagga cgttaaaggc gtgttttact tgttttttta agagtgtgtg atgtgtgttt tgtagatttc ttgacagtnn nnnnnnnnnn nnnnnnnnnn nnnngcctat ttaaagacnc tacgtgatct gattgagatg taca

<210> 142 <211> 547 <212〉 DNA <213>人類 <220> <223> Probe 33533—at HG-U95Av2 <220> <221〉mi sc一feature <222> 185, 237..266, 304, 305, 317..339, 347..349, 354..356 <223> n 為 a，g，c 或 t <220> <221〉 <222> <223〉 misc一feature 359, 361， 395, 445 n 為 a，g，c 或 t <400〉 142 aatagtattc agggatggat tgctcaatta tgaancccgg cagcagacat caaatataat atgtaccaac aatgaggaga tgtttttatc ttactgctaa actggatgga agaattattg attaaagaca aattagttta agaacatacc gatatgggct aagatcatcc cgagaggaga tatgtcagta gccatttcca aaaatttaaa ttgtgtggcg aatgatattg aaaaatnnnn 98677.doc -101 - 200533758 nnnnnnnnnn nnnnnnnnnn nnnnnntttg aggtgtcctt cccagatact atatcttctt catnnaaaga agtactnnnn nnnnnnnnnn nnnnnnnnna gaatgannna cttnnntana natattttga taaggcactg aaaatataaa aggantggta gtttactgat gtagatgtga attctgtata aagatgtgta aattnttttg agggttcatt aaattgcatg aatagagaca ggtcaaataa ataggcaaaa gggattttta cagttagaga tagaagagaa aaccattcac tgtattt< 210 > 142 < 211 > 547 < 212> DNA < 213 > Human < 220 > < 223 > Probe 33533-at HG-U95Av2 < 220 > < 221> mi sc-feature < 222 > 185, 237..266, 304, 305, 317..339, 347..349, 354..356 < 223 > n is a, g, c or t < 220 > < 221〉 < 222 > < 223> misc a feature 359, 361, 395, 445 n is a, g, c or t < 400> 142 aatagtattc agggatggat tgctcaatta tgaancccgg cagcagacat caaatataat atgtaccaac aatgaggaga tgtttttatc ttactgctaa actggatgga agaattattg attaaagaca aattagttta agaacatacc gatatgggct aagatcatcc cgagaggaga tatgtcagta gccatttcca aaaatttaaa ttgtgtggcg aatgatattg aaaaatnnnn 98677.doc -101 - 200533758 nnnnnnnnnn nnnnnnnnnn nnnnnntttg aggtgtcctt cccagatact atatcttctt catnnaaaga agtactnnnn nnnnnnnnnn nnnnnnnnna gaatgannna cttnnntana natattttga taaggcactg aaaatataaa aggantggta gtttactgat gtagatgtga attctgtata aagatgtgta aattnttttg agggttcatt aaattgcatg aatagagaca ggtcaaataa ataggcaaaa gggattttta cagttagaga tagaagagaa aaccattcac tgtatt t

<210> 143 <211> 450 <212〉 DNA <213>人類 <220> <223> Probe 33707_at HG-U95Av2 <220〉 <221> misc_feature <222〉 26, 86， 109， 168..190 <223〉n 為 a，g，c 或 t< 210 > 143 < 211 > 450 < 212> DNA < 213 > human < 220 > < 223 > Probe 33707_at HG-U95Av2 < 220> < 221 > misc_feature < 222> 26, 86, 109, 168..190 < 223> n is a, g, c or t

<400〉 143 cgtggccggg ctctactacc cgaagnatag tgcccgaagt tgctgcttgg catagatgag cctcagcttc cagggcactg tgggcntgtt ggtctactag ggccctgang tccacctggc cttcctgttc ttcactccct tcagccacac gcttcatggc cttgagtnnn nnnnnnnnnn nnnnnnnnnn ccaatcacca gtgaccagct agactgtgat tttgatagcg tcattcagaa gaaggcgtcc aaggagctga aggtggtgaa atttgtcctg caggtccctc gggagatcct 98677.doc -102- 200533758 ggagctggag catgagtgtc tgacaatcag aagcatcatg tccaatgtcc agatggccag aatgaatgtg atagttcaga ccaatgcctt ccactgctcc tttatgactg cacttctagc cagtagctct gcacaagtta gctctgtaga <210〉 144 <211> 428 <212〉 DNA <213>人類≪ 400> 143 cgtggccggg ctctactacc cgaagnatag tgcccgaagt tgctgcttgg catagatgag cctcagcttc cagggcactg tgggcntgtt ggtctactag ggccctgang tccacctggc cttcctgttc ttcactccct tcagccacac gcttcatggc cttgagtnnn nnnnnnnnnn nnnnnnnnnn ccaatcacca gtgaccagct agactgtgat tttgatagcg tcattcagaa gaaggcgtcc aaggagctga aggtggtgaa atttgtcctg caggtccctc gggagatcct 98677.doc -102- 200533758 ggagctggag catgagtgtc tgacaatcag aagcatcatg tccaatgtcc agatggccag aatgaatgtg atagttcaga ccaatgcctt ccactgctcc tttatgactg cacttctagc cagtagctct gcacaagtta gctctgtaga < 210〉 144 < 211 > 428 < 212〉 DNA < 213 > human

<220〉 <223> Probe 3373Lat HG-U95Av2 <220〉 <221> misc_feature <222> (72)..(72) <223〉n 為 a，g，c 或 t <220〉 <221> misc^feature <222〉 （79)..(79) <223> n 為 a，g，c 或 t< 220> < 223 > Probe 3373Lat HG-U95Av2 < 220> < 221 > misc_feature < 222 > (72) .. (72) < 223> n is a, g, c or t < 220 〉 ≪ 221 > misc ^ feature < 222〉 (79) .. (79) < 223 > n is a, g, c or t

<400〉 144 ctgtgtatgt cagttgctgc agaaatggat ttggaagatg gaggagagat gcccaagcaa cgggatccca antctaacna aacaccatct ggaatcctga tgtggaaagc aggggtttct ggtciactgg ctagagctaa ggaagttgaa aaggaaagct cacttctttg gaggcacctg tccagaagcc tggcctaggc agcttcaacc tttgaactta ctttttgaaa tgaaaagtaa tttatttgtt ttgctacata ctgttccaga cttttaaagg ggacaatgaa ggtgactgtg 98677.doc •103-≪ 400> 144 ctgtgtatgt cagttgctgc agaaatggat ttggaagatg gaggagagat gcccaagcaa cgggatccca antctaacna aacaccatct ggaatcctga tgtggaaagc aggggtttct ggtciactgg ctagagctaa ggaagttgaa aaggaaagct cacttctttg gaggcacctg tccagaagcc tggcctaggc agcttcaacc tttgaactta ctttttgaaa tgaaaagtaa tttatttgtt ttgctacata ctgttccaga cttttaaagg ggacaatgaa ggtgactgtg 98677.doc • 103-

200533758 gggaggagca tgtcaggttt gggcttggtt gttttagaag cacctgggtg tgcctaccta ctcctctttt cttttaaaag ggcccacaat gctccaattt cctgtctcct ttagagagac atgaaact <210> 145 <211> 531 <212〉 DNA <213>人類 <220> <223> Probe 33764_at HG-U95Av2 <220〉 <221> misc一feature <222> 121, 160, 244, 333..365, 415 <223> n 為 a，g，c 或 t <400〉 145 gtgtattacc agtatttact tgctttcttg atttcaccaa aaccaaattt aatttaaagg accacattaa tttttcaaag ggaaagagac aattaattgt acataatgta tacacacaca naaaaaaaaa tacctgtaga aatattattc cagcatagcn ggaaaacaaa caaaagtatt ggactgtcgg aggtgagcct gtgcgtctgt aaccctttgt gactcctgag cgtgcgctgt cttnctaggt taactcacga agtacattct ctgtcttact gatactgtag gttcacccat ttttttttaa tttcctcgca aataacaaga ccnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnttctt ttatatgcag caaacacacc gtccatttct gaagaggctt cggcntgaag gcattttcca atgatgttag tgcacaaaac gctttaaatt agactggaac tgccagaatc 98677.doc -104-200533758 gggaggagca tgtcaggttt gggcttggtt gttttagaag cacctgggtg tgcctaccta ctcctctttt cttttaaaag ggcccacaat gctccaattt cctgtctcct ttagagagac atgaaact &220; &220; < 210 > 145 < 211 > > < 210 > < 210 > < 210 > < 210 > > 〉 ≪ 221 > misc-feature < 222 > 121, 160, 244, 333..365, 415 < 223 > n is a, g, c or t &400; 145 gtgtattacc agtatttact tgctttcttg atttcaccaa aaccaaattt aatttaaattcacaagaa ggaaagagac aattaattgt acataatgta tacacacaca naaaaaaaaa tacctgtaga aatattattc cagcatagcn ggaaaacaaa caaaagtatt ggactgtcgg aggtgagcct gtgcgtctgt aaccctttgt gactcctgag cgtgcgctgt cttnctaggt taactcacga agtacattct ctgtcttact gatactgtag gttcacccat ttttttttaa tttcctcgca aataacaaga ccnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnttctt ttatatgcag caaacacacc gtccatttct gaagaggctt cggcntgaag gcattttcca atgatgttag tgcacaaaac gctttaaatt agactggaac tgccagaatc 98677.doc -104-

200533758 aaatgtaaat gaggaatttc tcgtacccct actgcatggt atcgattttt a <210〉 146 <211〉 361 <212〉 DNA <213> 人類 <220〉 <223> Probe 33772_at HG-U95Av2 <220> <221> misc_feature <222〉 （161)..(161) <223> n 為 a，g，c 或 t <400〉 146 ttgcttccag gtgtgcctgg catgggcctg gcccaggaag acaccacctc actgaggact ttgcgaatat cagagacctc agactcttca cagggtcagg actcagagag tgtcttactg gtggatgagg ctggtgggag cggcagggct gggcctgccc ntaaggggag ctccctgcaa gtcacatttc ccagtgaaac actgaactta tcagaaaaat gtatataata ggcaaggaaa gaaatacagt actgtttctg gacccttata aaatcctgtg caatagacac atacatgtca catttagctg tgctcagaag ggctatcatc atcctacaac tcacattaga gaacatcctg <210〉 147 <211〉 426 <212> DNA <213> 人類 98677.doc -105 -200533758 aaatgtaaat gaggaatttc tcgtacccct actgcatggt atcgattttt a < 210〉 146 < 211〉 361 < 212〉 DNA < 213 > human < 220> < 223 > Probe 33772_at HG-U95Av2 < 220 > & lt_221 <221; 222> (161) .. (161) < 223 > n is a, g, c or t < 400> 146 ttgcttccag gtgtgcctgg catgggcctg gcccaggaag acaccacctc actgaggact ttgcgaatat cagagacctc agactcttca cagggtcagg actcagagag tgtcttactg gtggatgagg ctggtgggag cggcagggct gggcctgccc ntaaggggag ctccctgcaa gtcacatttc ccagtgaaac actgaactta tcagaaaaat gtatataata ggcaaggaaa gaaatacagt actgtttctg gacccttata aaatcctgtg caatagacac atacatgtca catttagctg tgctcagaag ggctatcatc atcctacaac tcacattaga gaacatcctg < 210> 147 < 211> 426 < 212 > DNA < 213 > human 98677.doc -105 -

200533758 <220> <223〉 Probe 33790—at HG-U95Av2 <220〉 <221> raisc_feature <222〉 （145)..(163) <223〉 n 為 a, g，c 或 t <220〉 <221> misc_feature <222> 174..190, 192..286 <223> n 為 a，g，c 或 t <400> 147 cccacagcat gaagatctcc gtggctgcca ttcccttctt cctcctcatc accatcgccc tagggaccaa gactgaatcc tcctcacggg gaccttacca cccctcagag tgctgcttca cctacactac ctacaagatc ccgcnnnnnn nnnnnnnnnn nnntactatg agannnnnnn nnnnnnnnnn annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnagaa ctgagtgacc cagaaggggt ggcgaaggca cagctcagag acataaagag aagatgccaa ggccccctcc tccacccacc gctaactctc agccccagtc accctcttgg agcttccctg ctttgaatta aagacc <210> 148 <211> 129 <212> DNA <213> 人類 60 120 180 240 300 360 420 426 98677.doc -106- 200533758 <220〉 <223> Probe 33791_at HG-U95Av2 <400〉 148 agaatatcta gcatgtaagg cctttcaata ttaatataag cccaatatca gctctttctc tttgtatttc atctctttct actctcctat ttgtattttg tgttcctatc aaagtgtcgt atctgggag <210〉 149 <211〉 517 <212〉 DNA <213> 人類200533758 < 220 > < 223〉 Probe 33790-at HG-U95Av2 < 220〉 < 221 > raisc_feature < 222〉 (145) .. (163) < 223〉 n is a, g, c or t < 220> < 221 > misc_feature < 222 > 174..190, 192..286 < 223 > n is a, g, c or t < 400 > 147 cccacagcat gaagatctcc gtggctgcca ttcccttctt cctcctcaccgcct accggat acctgcc cccctcagag tgctgcttca cctacactac ctacaagatc ccgcnnnnnn nnnnnnnnnn nnntactatg agannnnnnn nnnnnnnnnn annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnagaa ctgagtgacc cagaaggggt ggcgaaggca cagctcagag acataaagag aagatgccaa ggccccctcc tccacccacc gctaactctc agccccagtc accctcttgg agcttccctg ctttgaatta aagacc < 210 > 148 < 211 > 129 < 212 > DNA < 213 > human 60 120 180 240 300 360 420 426 98677.doc -106- 200533758 < 220〉 < 223 > Probe 33791_at HG-U95Av2 < 400〉 148 agaatatcta gcatgtaagg cctttcaata ttaatataag cccaatatca gctctttctc tttgta tttc atctctttct actctcctat ttgtattttg tgttcctatc aaagtgtcgt atctgggag < 210〉 149 < 211〉 517 < 212〉 DNA < 213 > human

<220〉 <223> Probe 33802_at HG-U95Av2 <220〉 <221> misc_feature <222> (32)..(32) <223> n 為 a，g，c 或 t <220〉 <221〉 <222〉 <223> misc一feature (42)..(58) n 為 a，g，c 或 t <220> <221> misc_feature <222> (60)..(62) <223〉 n 為 a，g，c 或 t 98677.doc 107- <220〉< 220> < 223 > Probe 33802_at HG-U95Av2 < 220> < 221 > misc_feature < 222 > (32) .. (32) < 223 > n is a, g, c or t < 220 〉 ≪ 221〉 < 222〉 < 223 > misc-feature (42) .. (58) n is a, g, c or t < 220 > < 221 > misc_feature < 222 > (60). . (62) < 223> n is a, g, c or t 98677.doc 107- < 220>

200533758 <221> misc—feature <222〉 （400)..(400) <223〉n 為 a，g，c 或 t <400〉 149 ttctttctag agagggaatt ctcttggctg gnttccttac cnnnnnnnnn nnnnnnnntn nngggcctcc agccctctca ctgtgtccct ctctctggaa aggaggaagg agcctatggc atcttcccca acgaaaagca catccaggca atggcctaaa cttcagaggg ggcgaaggga tcagccctgc ccttcagcat cctcagttcc tgcagcagag cctggaagac accctaatgt ggcagctgtc tcaaacctcc aaaagccctg agtttcaagt atccttgttg acacggccat gaccactttc cccgtgggcc atggcaattt ttacacaaac ctgaaaagat gttgtgtctt gtgtttttgt cttatttttg ttggagccac tctgttcctn gctcagcctc aaatgcagta tttttgttgt gttctgttgt ttttatagca gggttggggt ggtttttgag ccatgcgtgg gtggggaggg aggtgtttaa cggcactgtg gccttgg • <210〉 150 <211> 528 <212〉 DNA <213>人類 <220> <223〉 Probe 33803—at HG-U95Av2 <220〉 <221> misc一feature <222> (186)..(186) <223> n 為 a，g，c 或 t 60 120 180 240 300 360 420 480 517 98677.doc -108- 200533758 <400> 150200533758 < 221 > misc—feature < 222〉 (400) .. (400) < 223〉 n is a, g, c or t < 400> 149 ttctttctag agagggaatt ctcttggctg gnttccttac cnnnnnnnnn nnnnnnnntn nngggggcct cc actct agcc atcttcccca acgaaaagca catccaggca atggcctaaa cttcagaggg ggcgaaggga tcagccctgc ccttcagcat cctcagttcc tgcagcagag cctggaagac accctaatgt ggcagctgtc tcaaacctcc aaaagccctg agtttcaagt atccttgttg acacggccat gaccactttc cccgtgggcc atggcaattt ttacacaaac ctgaaaagat gttgtgtctt gtgtttttgt cttatttttg ttggagccac tctgttcctn gctcagcctc aaatgcagta tttttgttgt gttctgttgt ttttatagca gggttggggt ggtttttgag ccatgcgtgg gtggggaggg aggtgtttaa cggcactgtg gccttgg • < 210> 150 < 211 > 528 < 212> DNA < 213 > Human < 220 > < 223> Probe 33803-at HG-U95Av2 < 220> < 221 > misc-feature < 222 > (186) .. (186) < 223 > n is a, g, c or t 60 120 180 240 300 360 420 480 517 98677.doc -108- 200533758 < 400 > 150

tttctaccat ttcagagagg ccttttggaa tgtggcccct gaacaagaat tggaagctgc cctgcccatg ggagctggtt agaaatgcag aatcctaggc tccaccccat ccagttcatg agaatctata tttaacaaga tctgcagggg gtgtgtctgc tcagtaattt gaggacaacc attccnagac tgcttccaat tttctggaat acatgaaata tagatcagtt ataagtagca ggccaagtca ggcccttatt ttcaagaaac tgaggaattt tctttgtgta gctttgctct ttggtagaaa aggctaggta cacagctcta gacactgcca cacagggtct gcaaggtctt tggttcagct aagctaggaa tgaaatcctg cttcagtgta tggaaataaa tgtatcatag aaatgtaact tttgtaagac aaaggttttc ctcttctatt ttgtaaactc aaaatatttg tacatagtta tttatttatt ggagataatc tagaacacag gcaaaatc <210〉 151 <211> 606 <212〉 DNA <213>人類 <220〉 <223> Probe 33849_at HG-U95Av2 <220〉 <221> misc一feature <222> 392..394, 396, 398, 399, 401..403, 405, 445..448, 553 <223> n 為 a, g，c 或 t <400〉 151 tcttactgga atgtctaggc actgtacagt tattatatat cttggttgtt gtattgtacc 98677.doc -109- 120 200533758 180 240 300 360 420 480 540 600 606tttctaccat ttcagagagg ccttttggaa tgtggcccct gaacaagaat tggaagctgc cctgcccatg ggagctggtt agaaatgcag aatcctaggc tccaccccat ccagttcatg agaatctata tttaacaaga tctgcagggg gtgtgtctgc tcagtaattt gaggacaacc attccnagac tgcttccaat tttctggaat acatgaaata tagatcagtt ataagtagca ggccaagtca ggcccttatt ttcaagaaac tgaggaattt tctttgtgta gctttgctct ttggtagaaa aggctaggta cacagctcta gacactgcca cacagggtct gcaaggtctt tggttcagct aagctaggaa tgaaatcctg cttcagtgta tggaaataaa tgtatcatag aaatgtaact tttgtaagac aaaggttttc ctcttctatt ttgtaaactc aaaatatttg tacatagtta tttatttatt ggagataatc tagaacacag gcaaaatc < 210〉 151 < 211 > 606 < 212〉 DNA < 213 > human < 220〉 < 223 > Probe 33849_at HG-U95Av2 < 220〉 < 221 > misc-feature < 222 >; 392..394, 396, 398, 399, 401..403, 405, 445..448, 553 < 223 > n is a, g, c or t < 400〉 151 tcttactgga atgtctaggc actgtacagt tattatatat cttggttgtt gtattgtacc 98677 .doc -109- 120 200533758 180 240 300 360 420 480 540 600 606

agtgaaatgc caaatttgaa aggcctgtac tgcaatttta tatgtcagag attgcctgtg gctctaatat gcacctcaag attttaagga gataatgttt ttagagagaa tttctgcttc cactatagaa tatatacata aatgtaaaat acttacaaaa gtggaagtag tgtattttaa agtaattaca cttctgaatt tatttttcat attctatagt tggtatgact taaatgaatt actggagtgg gtagtgagtg tacttaaatg tttcaattct gttatatttt ttattaagtt tttaaaaaat taaattggat attaaattgt annnananna nnnantaatt ttaaactgaa tgccctcaat aagtaatact gaagnnnntt cttaaatgaa gataaattat ctccaatgaa aagcatgaca tgtgtttcaa tagaagaatc ttaagttggc taaattcaaa gtgcttgaca tcaaaatgtt ctngagtgat tagctactag attctgaatc atacatcaca tctgactaga gaccag <210> 152 <211> 440 <212〉 DNA <213> 人類 <220> <223> Probe 33862—at HG-U95Av2 <220> <221> misc一feature <222〉 （407)..(408) <223> n 為 a，g，c 或 t <400〉 152 tcacttggcg aggagcccgc ctgctccggc ccctcctgca gttcaccttg atcatgatgg 60 98677.doc -110- 120 200533758 ccttctacac gggactgtct caggatttgc tcaaggagcc tcaagactaa gacgacgctc ctgtggacat tattgacagg gagctgtttt tgtaaaatga acagtagaat gtagggaaaa ttttactatg tggccttcca cgcgtatcag accacaagca ctggtggcct gctgcatagt tccctgcctg cccctgctat aacaatcacc acaacatgat ctgctgacag caagttcttg acttttgccc gactgatttt ccatcccagt gatgttctgg tttcttcgtg tctgacctct ccggaaggaa atcctttcac gtaggtgcca cccacctcct ctgctctcca atctcatcag taaaaannaa aaaaaaaatg 180 240 300 360 420 440 <210〉 153 <211> 518 <212〉 DNA <213>人類 <220> <223> Probe 3390(Lat HG-U95Av2 <220〉 <221〉 <222〉 <223〉agtgaaatgc caaatttgaa aggcctgtac tgcaatttta tatgtcagag attgcctgtg gctctaatat gcacctcaag attttaagga gataatgttt ttagagagaa tttctgcttc cactatagaa tatatacata aatgtaaaat acttacaaaa gtggaagtag tgtattttaa agtaattaca cttctgaatt tatttttcat attctatagt tggtatgact taaatgaatt actggagtgg gtagtgagtg tacttaaatg tttcaattct gttatatttt ttattaagtt tttaaaaaat taaattggat attaaattgt annnananna nnnantaatt ttaaactgaa tgccctcaat aagtaatact gaagnnnntt cttaaatgaa gataaattat ctccaatgaa aagcatgaca tgtgtttcaa tagaagaatc ttaagttggc taaattcaaa gtgcttgaca tcaaaatgtt ctngagtgat tagctactag attctgaatc atacatcaca tctgactaga gaccag < 210 > 152 < 211 > 440 < 212> DNA < 213 > human < 220 > < 223 > Probe 33862-at HG-U95Av2 < 220 > < 221 > mis feature < 222〉 (407) .. (408) < 223 > n is a, g, c or t < 400〉 152 tcacttggcg aggagcccgc ctgctccggc ccctcctgca gttcaccttg atcatgatgg 60 98677.doc -110- 120 200533758 ccttctacacgggggtacacgg tcaagactaa gacgacgctc ctg tggacat tattgacagg gagctgtttt tgtaaaatga acagtagaat gtagggaaaa ttttactatg tggccttcca cgcgtatcag accacaagca ctggtggcct gctgcatagt tccctgcctg cccctgctat aacaatcacc acaacatgat ctgctgacag caagttcttg acttttgccc gactgatttt ccatcccagt gatgttctgg tttcttcgtg tctgacctct ccggaaggaa atcctttcac gtaggtgcca cccacctcct ctgctctcca atctcatcag taaaaannaa aaaaaaaatg 180 240 300 360 420 440 < 210> 153 < 211 > 518 < 212〉 DNA < 213 > Human < 220 > < 223 > Probe 3390 (Lat HG-U95Av2 < 220〉 < 221〉 < 222〉 < 223〉

misc一feature 31， 39, 41， 50..52, 58, 61， 63..69, 71..77, 79, 82..89 n 為 a，g，c 或 t <220> <221> misc_feature <222> 91, 92, 95, 117..209, 319..339, 398..412 <223> n 為 a, g，c 或 t <400> 153 60 tgtgacatcc ggagtcctgg agccgggtgt nccagtggna ncactaggtn nntgctgnct ncnnnnnnng nnnnnnncnc annnnnnnnt nnttngtccc ccacaacctg ccccggnnnn 98677.doc -Ill - 120 180 200533758misc-feature 31, 39, 41, 50..52, 58, 61, 63..69, 71..77, 79, 82..89 n is a, g, c or t < 220 > < 221 > misc_feature < 222 > 91, 92, 95, 117..209, 319..339, 398..412 < 223 > n is a, g, c or t < 400 > 153 60 tgtgacatcc ggagtcctgg agccgggtgt nccagtggna ncactaggtn nntgctgnct ncnnnnnnng nnnnnnncnc annnnnnnnt nnttngtccc ccacaacctg ccccggnnnn 98677.doc -Ill-120 180 200533758

240 300 360 420 480 518 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt tctcccacga cggctcaccc tcccctccat ctgcgttgat gctcagaatc gcctacctgt gcctgcgtgt aaaccacagc ctcagaccag ctatggggag aggacaacnn nnnnnnnnnn nnnnnnnnnc ggtctggggt gaggagtgtg gggagcttgg gcatcctcct ccagcctcct ccagcccnnn nnnnnnnnnn nncctgtggt gcccagaaaa gtgcccctag gttggtgggt ctacaggagc ctcagccagg cagcccaccc caccctgggg ccctgcctca ccaaggaaat aaagactc <210〉 154 <211〉 351 <212〉 DNA <213>人類 <220> <223> Probe 33925一at HG-U95Av2 <220〉 <221〉 <222> <223〉 misc一feature (180)..(180) n 為 a，g，c 或 t <220> <221> misc_feature <222> (306)..(308) <223> n 為 a，g，c 或 t <220〉 <221> misc一feature 98677.doc -112-240 300 360 420 480 518 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt tctcccacga cggctcaccc tcccctccat ctgcgttgat gctcagaatc gcctacctgt gcctgcgtgt aaaccacagc ctcagaccag ctatggggag aggacaacnn nnnnnnnnnn nnnnnnnnnc ggtctggggt gaggagtgtg gggagcttgg gcatcctcct ccagcctcct ccagcccnnn nnnnnnnnnn nncctgtggt gcccagaaaa gtgcccctag gttggtgggt ctacaggagc ctcagccagg cagcccaccc caccctgggg ccctgcctca ccaaggaaat aaagactc < 210> 154 < 211〉 351 < 212〉 DNA < 213 > human < 220 > < 223 > Probe 33925-at HG-U95Av2 < 220> < 221〉 < 222 > < 223〉 misc-feature (180) .. (180) n is a, g, c or t < 220 > < 221 > misc_feature < 222 > (306) .. (308) < 223 > n is a, g, c or t < 220〉 < 221 > misc-feature 98677.doc -112-

200533758 <222〉 （199)..(199) <223> η 為 a，g，c 或 t <220> <221> misc_feature <222> (322)..(323) <223> n 為 a，g，c 或 t <400〉 154 ttggtttcgg acgacccttg ctctgaccgg aagagaagtc cctatcccac acctgcctgt cacgttccct cccctttccc cagcgcactg ttgagggcag cctctccagc tctcttgttt atgcaaacgc cgagcgcctg ggaggctcgg taggaggagt cttccacggc cccgccccgn ccctgtcggt cccgccctnc cccccgccgg gctcctgggg ctgtggccga aaggtttctg atctccgtgt gtgcatgtga ctgtgctggg ttggaatgtg aacaataaag aggaatgtcc aagtgnnnaa aaaaaaaaaa annagggagt ttgggtgcac aaggcctccg c <210〉 155 <211> 330 <212〉 DNA <213> 人類 <220〉 <223> Probe 33943_at HG-U95Av2 <220〉 <221> misc_feature <222> (33),.(63) <223> n 為 a，g，c 或 t 60 120 180 240 300 351 98677.doc -113 - 200533758 <220〉 <221> misc_feature <222〉 （123)..(123) <223〉n 為 a, g，c 或 t <220> <221> mi sc一feature <222〉 （144)..(144) <223> n 為 a，g，c 或 t <400〉 155 gtgaccacgt gaccaacttg cgcaagatgg gannnnnnnn nnnnnnnnnn nnnnnnnnnn 60 nnnttgacaa gcacaccctg ggagacagtg ataatgaaag ctaagcctcg ggctaatttc 120 ccnatagccg tggggtgact tccntggtca ccaaggcagt gcatgcatgt tggggtttcc 180 tttacctttt ctataagttg taccaaaaca tccacttaag ttctttgatt tgtaccattc 240 ttcaaataaa gaaatttggt acccaggtgt tgtctttgag gtcttggatg aatcagaaat 300 330 ctatccaggc tatcttccag attccttaag200533758 < 222> (199) .. (199) < 223 > η is a, g, c or t < 220 > < 221 > misc_feature < 222 > (322) .. (323) < 223 > n is a, g, c or t < 400> 154 ttggtttcgg acgacccttg ctctgaccgg aagagaagtc cctatcccac acctgcctgt cacgttccct cccctttccc cagcgcactg ttgagggcag cctctccagc tctcttgttt atgcaaacgc cgagcgcctg ggaggctcgg taggaggagt cttccacggc cccgccccgn ccctgtcggt cccgccctnc cccccgccgg gctcctgggg ctgtggccga atctccgtgt gtgcatgtga ctgtgctggg ttggaatgtg aacaataaag aggaatgtcc aagtgnnnaa aaaaaaaaaa annagggagt aaggtttctg ttgggtgcac aaggcctccg c < 210> 155 < 211 > 330 < 212> DNA < 213 > human < 220> < 223 > Probe 33943_at HG-U95Av2 < 220> < 221 > misc_feature < 222 > (33) ,. (63) < 223 > n is a, g, c or t 60 120 180 240 300 300 351 98677.doc -113-200533758 < 220〉 < 221 > misc_feature < 222> (123) .. (123). 123) < 223> n is a, g, c or t < 220 > < 221 > mi sc-feature < 222> (144) .. (144) < 223 > n a, g, c or t < 400> 155 gtgaccacgt gaccaacttg cgcaagatgg gannnnnnnn nnnnnnnnnn nnnnnnnnnn 60 nnnttgacaa gcacaccctg ggagacagtg ataatgaaag ctaagcctcg ggctaatttc 120 ccnatagccg tggggtgact tccntggtca ccaaggcagt gcatgcatgt tggggtttcc 180 tttacctttt ctataagttg taccaaaaca tccacttaag ttctttgatt tgtaccattc 240 ttcaaataaa gaaatttggt acccaggtgt tgtctttgag gtcttggatg aatcagaaat 300 330 ctatccaggc tatcttccag attccttaag

類 5669DNA人 1 5 D <210〉 <211〉 <212> <213〉 <220> <223> Probe 34022_at HG-U95Av2 <220> <221> misc一feature <222〉 33, 39, 42, 46, 53, 60, 65, 93 <223> η 為 a，g，c 或 t 98677.doc -114- 60 60Class 5669DNA human 1 5 D < 210〉 < 211〉 < 212 > < 213〉 < 220 > < 223 > Probe 34022_at HG-U95Av2 < 220 > < 221 > misc-feature < 222〉 33, 39, 42, 46, 53, 60, 65, 93 < 223 > η is a, g, c or t 98677.doc -114- 60 60

200533758 <400> 156 gtatcattga cacttcctgc agggtggtcc ctngccctna cnaganctga aantgaaaan gagancagca gctttctagg gacagctgga aanggactta atgtgtttga ctatttctta cgagggttct acttatttat gtatttattt ttgaaagctt gtattttaat attttacatg ctgttattta aagatgtgag tgtgtttcat caaacatagc tcagtcctga ttatttaatt ggaatatgat gggttttaaa tgtgtcatta aactaatatt tagtgggaga ccataatgtg tcagccacct tgataaatga cagggtgggg aactggaggg tggggggatt gaaatgcaag caattagtgg atcactgtta gggtaaggga atgtatgtac acatctattt tttatacttt ttttttaaaa aaagaatgtc agttgttatt tattcaaatt atctcacatt atgtgttcaa catttttatg ctgaagtttc ccttagacat tttatgtctt gcttgtaggg cataatgcct tgtttaatgt ccattctgca gcgtttctc <210> 157 <211〉 410 <212〉 DNA <213> 人類 <220> <223> Probe 34075_at HG-U95Av2 <220〉 <221> misc_feature <222〉 40..70, 330， 331， 344, 346, 347, 357 <223> n 為 a, g，c 或 t 120 180 240 300 360 420 480 540 569 98677.doc -115 - 200533758 <400〉 157200533758 < 400 > 156 gtatcattga cacttcctgc agggtggtcc ctngccctna cnaganctga aantgaaaan gagancagca gctttctagg gacagctgga aanggactta atgtgtttga ctatttctta cgagggttct acttatttat gtatttattt ttgaaagctt gtattttaat attttacatg ctgttattta aagatgtgag tgtgtttcat caaacatagc tcagtcctga ttatttaatt ggaatatgat gggttttaaa tgtgtcatta aactaatatt tagtgggaga ccataatgtg tcagccacct tgataaatga cagggtgggg aactggaggg tggggggatt gaaatgcaag caattagtgg atcactgtta gggtaaggga atgtatgtac acatctattt tttatacttt ttttttaaaa aaagaatgtc agttgttatt tattcaaatt atctcacatt atgtgttcaa catttttatg ctgaagtttc ccttagacat tttatgtctt gcttgtaggg cataatgcct tgtttaatgt ccattctgca gcgtttctc < 210 < 212 > 212 < 212> DNA < 221 > misc_feature < 222〉 40..70, 330, 331, 344, 346, 347, 357 < 223 > n is a, g, c or t 120 180 240 300 360 420 480 540 569 98677.doc -115-200533758 < 400〉 157

aggacaacga ctaccaccgc agcgacgagc aggtgagcan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn cgggctgaag cggaagtgga tccgctgctc agcccaggcg accgtcttgc atctgaagaa gttcatcgcc aaaaaactca acctttcatc ctttaacgag ctggacattt tatgcaacga ggagatcctg ggcaaggacc acacactcaa gttcgtggtt gtcactaggt ggagattcaa gaaggcgccg ctcctgctgc actacagacc caagatggac ttgctgtgaa tggtgccaca cagcgcccac agactgggcn ntcgcaccct tggntnntcc cggccgncgc gettaagaac attgcctctg ggtgtcatgt ggaccagact tetgaataga <210〉 158 <211> 578 <212〉 DNA <213>人類 <220〉 <223> Probe 34082_at HG-U95Av2 <220> <221> misc_feature <222> 96, 97, 99, 113, 115, 120..178, 238..252 <223> n 為 a，g，c 或 t <220〉 <221> misc_feature <222〉 313, 522, 536, 542 <223> n 為 a，g，c 或 t <400〉 158 actctgtgcc cgaatggtgg tgcaggcgcc ctgtcctggt tgtgttgtta cgtgtttgac 9N677.doc -116- 120 120aggacaacga ctaccaccgc agcgacgagc aggtgagcan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn cgggctgaag cggaagtgga tccgctgctc agcccaggcg accgtcttgc atctgaagaa gttcatcgcc aaaaaactca acctttcatc ctttaacgag ctggacattt tatgcaacga ggagatcctg ggcaaggacc acacactcaa gttcgtggtt gtcactaggt ggagattcaa gaaggcgccg ctcctgctgc actacagacc caagatggac ttgctgtgaa tggtgccaca cagcgcccac agactgggcn ntcgcaccct tggntnntcc cggccgncgc gettaagaac attgcctctg ggtgtcatgt ggaccagact tetgaataga < 210> 158 < 211 > 578 < 212> DNA < 213 > Human < 220> < 223 > Probe 34082_at HG-U95Av2 < 220 > < 221 > misc_feature < 222 > 96, 97, 99, 113, 115, 120 ... 178, 238..252 < 223 > n is a, g, c or t < 220〉 < 221 > misc_feature < 222〉 313, 522, 536, 542 < 223 > n is a, g, c Or t < 400> 158 actctgtgcc cgaatggtgg tgcaggcgcc ctgtcctggt tgtgttgtta cgtgtttgac 9N677.doc -116- 120 120

200533758 cagcacaggg gtccggtggg gaaaatgtat gggttnntnt cagttgttgc tantnctgan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnat gattgtgttt aggtttgaaa ttgctcaagt gtctggctca ggtggtggtt ctgagacnnn nnnnnnnnnn nngagcccag atgcttaggt ccactagggc ccatctaggg aagggaaagg agatttcagc ggnttccccg aaaggaacag gactgtcggg atgcttcccg gatgtctaca gttgcccctt cctgcagtga gattactgct tcctgtttcc ctccagctct tcccagcagc agtgagggag tattaagagg gatcttgtag tcgctgcctg gctcttgtgg gcggcccttt aagactcagg ttgagctcag ccaagtcccg cttgcgccag gntttgattc aaggtngtca gnaagttaga ttgtcaaaac atttcgagag agaggcag &lt;210&gt; 159 &lt;211&gt; 353 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 φ &lt;223&gt; Probe 34209_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （196)..(196) 〈223〉n 為 a，g，c 或 t &lt;400〉 159 agatccggcc tcaggactta cacctcctgc ctgaccccca ggcttctctc tcctttctcc cagcaaactg cagtggcaga aaggaggttc agaggctggg aaagtgggcc tccccttgca 180 240 300 360 420 480 540 578 60 98677.doc -117- 120 200533758 actcagagct gctgggtgtg gcctgatcca catagccagg gctgcactca tgtcanaggc aaccaaagac tcttcctggc ggagggcccc gcagggtggg tgtagaaccc ccttgaggct atccaatccc tggggctgcc tggggtgtgg gggctggcgg gggcccctgc agccaggacc ctaacggccc acaggcacct agggaaaagc ctggcctgca ctccagcacc acc200533758 cagcacaggg gtccggtggg gaaaatgtat gggttnntnt cagttgttgc tantnctgan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnat gattgtgttt aggtttgaaa ttgctcaagt gtctggctca ggtggtggtt ctgagacnnn nnnnnnnnnn nngagcccag atgcttaggt ccactagggc ccatctaggg aagggaaagg agatttcagc ggnttccccg aaaggaacag gactgtcggg atgcttcccg gatgtctaca gttgcccctt cctgcagtga gattactgct tcctgtttcc ctccagctct tcccagcagc agtgagggag tattaagagg gatcttgtag tcgctgcctg gctcttgtgg gcggcccttt aagactcagg ttgagctcag ccaagtcccg cttgcgccag gntttgattc aaggtngtca gnaagttaga ttgtcaaaac atttcgagag agaggcag &lt; 210 &gt; 159 &lt; 211 &gt; 353 &lt; 212〉 DNA &lt; 213〉 Human &lt; 220〉 φ &lt; 223 &gt; Probe 34209_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222> (196) .. (196) <223> n is a, g, c, or t &lt; 400> 159 agatccggcc tcaggactta cacctcctgc ctgaccccca ggcttctctc tcctttctcc cagcaaactg cagtggcaga aaggaggttc agaggctggg aaagtgdoc cc cc 480 300 540 cc 480 cc 300 cc cc cc 480 117- 120 200533758 actcagagct gctgggtgtg gcctgatcca catagccagg gctgcactca tgtcanaggc aaccaaagac tcttcctggc ggagggcccc gcagggtggg tgtagaaccc ccttgaggct atccaatccccagg ggggggccgggccgggccgggcc

&lt;210〉 160 &lt;211〉 529 &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223&gt; Probe 34232HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （43)..(57) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc^feature φ &lt;222〉 （116)..(130) &lt;223&gt; n 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （217)..(274) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 160 atatggcaac ggaacatcct caagcagagg tagtaaaaca ggnnnnnnnn nnnnnnnaaa 98677.doc -118 - 200533758&lt; 210〉 160 &lt; 211〉 529 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 34232HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 (43): (57) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc ^ feature φ &lt; 222> (116) .. (130) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (217) .. (274) .. (274) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 160 atatggcaac ggaacatcct caagcagagg tagtaaaaca ggnnnnnnnnnnnnnnnnnaaa 98677. doc -118-200533758

gtaaagtgtt gggtgaagtg gggaaacagg acagcagctc tgctagcttg gctagnnnnn nnnnnnnnnn cgggaagaag gaggtggctg agaagagcca gatcaacctc attgataaga aatggaagcc cctgcaaggt gtggggaacc tggcagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaatgaa accacaaggc ttgagaatag aaattaaaag caaaaataaa gttcggcctg ggtctctctt tgatgaagta agaaagacag cacgcttaaa ccgtagacca agaaatcagg agagttcaag tgatgagcag acgcctagtc gggatgatga tagccagtcc aggagtccaa gtagatctcg aagtaaatct gaaaccaaat caagacacag aacaaggtct gtctcctata gtcactcaag aagtcgatc &lt;210〉 161 &lt;211&gt; 487 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 34261—at HG-U95Av2 &lt;221&gt; misc_feature &lt;222〉 （425)..(427) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 161 ctctaactgg cctggctctg gaagggctgg tgaggactct gcctccttgc ctgcctacaa ggtgcctggt ttgcagcagg ctctccgctc tttccagcaa agctgctcag agagggtgtc cagcacagtg gagaggccgg aagtgagacg ggcagacggc acctgcagcc tgaaacgcac 98677.doc -119- 240 200533758 cgctcctgcg tgcgccccca cctggtcccc ggatgccccc accacctgga cagaggccac actgactgcc cacccagctg tggcgggagg tgcagagcag agggctttag ggagcagtga ctgcggtcac ccctttagtt ctctgggtgt agaccacacc acctcccact gggcaccccc caacacggtg tcctgccacc cagcgcctgg ctccaggaaa acacgcttgc cttccttccc ggcannntcg ccactctcct tatggactct gttctgtttg tacatggctg acggaaatct ctttggtgtaaagtgtt gggtgaagtg gggaaacagg acagcagctc tgctagcttg gctagnnnnn nnnnnnnnnn cgggaagaag gaggtggctg agaagagcca gatcaacctc attgataaga aatggaagcc cctgcaaggt gtggggaacc tggcagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaatgaa accacaaggc ttgagaatag aaattaaaag caaaaataaa gttcggcctg ggtctctctt tgatgaagta agaaagacag cacgcttaaa ccgtagacca agaaatcagg agagttcaag tgatgagcag acgcctagtc gggatgatga tagccagtcc aggagtccaa gtagatctcg aagtaaatct gaaaccaaat caagacacag aacaaggtct gtctcctata gtcactcaag aagtcgatc &lt; 210 〉 161 &lt; 211 &gt; 487 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 34261-at HG-U95Av2 &lt; 221 &gt; misc_feature &lt; 222> (425) .. (427) &lt;; 223 &gt; n is a, g, c or t &lt; 400> 161 ctctaactgg cctggctctg gaagggctgg tgaggactct gcctccttgc ctgcctacaa ggtgcctggt ttgcagcagg ctctccgctc tttccagcaa agctgctcag agagggtgtc cagcacagtg gagaggccgg aagtgagacg ggcagacggc acctgcagcc tgaaacgcac 98677.doc -119- 240 200533758 cgctcctgcg tgcgccccca cctggtcccc ggatgcccc c accacctgga cagaggccac actgactgcc cacccagctg tggcgggagg tgcagagcag agggctttag ggagcagtga ctgcggtcac ccctttagtt ctctgggtgt agaccacacc acctcccact gggcaccccc caacacggtg tcctgccacc cagcgcctgg ctccaggaaa acacgcttgc cttccttccc ggcannntcg ccactctcct tatggactct gttctgtttg tacatggctg acggaaatct ctttggt

300 360 420 480 487 &lt;210&gt; 162 &lt;211&gt; 475 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 34265—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （352)..(385) &lt;223&gt; n 為 a，g，c 或 t300 360 420 480 487 &lt; 210 &gt; 162 &lt; 211 &gt; 475 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 34265-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222> (352) .. (385) &lt; 223 &gt; n is a, g, c or t

&lt;400&gt; 162 gatgctagac gaaaacccac attacctgtt aggcctcagc atggcttatg tgcacgtgta aatggagtcc ctgtgaatga cagcatgttt cttacataga taattatgga tacaaagcag ctgtatgtag atagtgtatt gtcttcacac cgatgattct gctttttgct aaattagaat aagagctttt ttgtttcttg ggtttttaaa atgtgaatct gcaatgatca taaaaattaa aatgtgaatg tcaacaataa aaagcaagac tatgaaaggc tcagatttct tgcagtttaa 60 120 180 240 98677.doc -120- 300 360 200533758 aatggtgtct gaggttgtac tattttggcc aagtctgtag aaagctgtca tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntgggc attgttatac accagtaaag aaggctgtac tcaagaggag gagctgacac atttcacttg gctgcgtctt aataaacatg aatgc &lt;210&gt; 163 &lt;211&gt; 403 &lt;212〉 DNA &lt;213&gt;人類&Lt; 400 &gt; 162 gatgctagac gaaaacccac attacctgtt aggcctcagc atggcttatg tgcacgtgta aatggagtcc ctgtgaatga cagcatgttt cttacataga taattatgga tacaaagcag ctgtatgtag atagtgtatt gtcttcacac cgatgattct gctttttgct aaattagaat aagagctttt ttgtttcttg ggtttttaaa atgtgaatct gcaatgatca taaaaattaa aatgtgaatg tcaacaataa aaagcaagac tatgaaaggc tcagatttct tgcagtttaa 60 120 180 240 98677.doc -120- 300 360 200533758 aatggtgtct gaggttgtac tattttggcc aagtctgtag aaagctgtca tnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntgggc attgttatac accagtaaag aaggctgtac tcaagaggag gagctgacac atttcacttg gctgcgtlt aataaacatg aatgc &lt; 210

420 475 &lt;220〉 &lt;223&gt; Probe 34272_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (46)..(62) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 331..346, 349..370 &lt;223&gt; n 為 a，g，c 或 t420 475 &lt; 220> &lt; 223 &gt; Probe 34272_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (46) .. (62) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 331..346, 349..370 &lt; 223 &gt; n is a, g, c or t

&lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （378)..(378) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 163 60 tgaattcatc tcagtccagg caaccaaaga ggtgaacctg gattcnnnnn nnnnnnnnnn nncaagccgg aacatgctag agcctacaat aacctgcttt gatgaggccc agaagaagat 98677.doc -121 - 120 180 180&lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (378) .. (378) &lt; 223 &gt; n is a, g, c or t &lt; 400> 163 60 tgaattcatc tcagtccagg caaccaaaga ggtgaacctg gattcnnnnn nnnnnnnnnnnnnncagcct agcat agcat gatgaggccc agaagaagat 98677.doc -121-120 180 180

200533758 tttcaacctg atggagaagg attcctaccg ccgcttcctc aagtctcgat tctatcttga tttggtcaac ccgtccagct gtggggcaga aaagcagaaa ggagccaaga gttcagcaga ctgtgcttcc ctggtccctc agtgtgccta attctcacct gaaggcagag ggatgaaatg ccaagactct atgctctgga aaacctgagg nnnnnnnnnn nnnnnnatnn nnnnnnnnnn nnnnnnnnnn attgtagnct aatattcatg ctgcctgcca tgt &lt;210&gt; 164 &lt;211&gt; 596 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 34273—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （512)..(571) &lt;223&gt; n 為 a，g，c 或 t • &lt;400〉 164 tgatttgacc actgacagcc tccaccttga gcactattct aaggagcaaa taccttagct cccttgagct ggttttctct gatggcactt ttgagctcct aagctgccag ccttcccttc ttttcctggg tgctcagggc atgcttatta gcagctgggt tggtatggag ttggcagaca ggatgttcaa cttaatgaag aaatacagct aaggccttgc cagcaacacc tgccgtaagt tactggctga gtgagggcat agaagttaaa ggttactgtt tttatcctct atcctttttt cctttcctga tcaaggtgct cttctcattt tttcctgaga accttagcca tcagatgagg 240 300 360 403 60 120 180 240 300 98677.doc -122- 360 200533758 ctccttagtt tattgtggtt ggttgttttt tctttataat ggctctgggc tatatgccca tatttataaa ccagcagcag gggaaagatt atattttata agagggaaca aattttcaca atttgaaaag cccacataag ttttctcttt tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nctttttagg ctctgagact aaatga200533758 tttcaacctg atggagaagg attcctaccg ccgcttcctc aagtctcgat tctatcttga tttggtcaac ccgtccagct gtggggcaga aaagcagaaa ggagccaaga gttcagcaga ctgtgcttcc ctggtccctc agtgtgccta attctcacct gaaggcagag ggatgaaatg ccaagactct atgctctgga aaacctgagg nnnnnnnnnn nnnnnnatnn nnnnnnnnnn nnnnnnnnnn attgtagnct aatattcatg ctgcctgcca tgt &lt; 210 &gt; 164 &lt; 211 &gt; 596 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 34273-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (512) .. (571) &lt; 223 &gt; n is a, g, c or t • &lt; 400> 164 tgatttgacc actgacagcc tccaccttga gcactattct aaggagcaaa taccttagct cccttgagct ggttttctct gatggcactt ttgagctcct aagctgccag ccttcccttc ttttcctggg tgctcagggc atgcttatta gcagctgggt tggtatggag ttggcagaca ggatgttcaa cttaatgaag aaatacagct aaggccttgc cagcaacacc tgccgtaagt tactggctga gtgagggcat agaagttaaa ggttactgtt tttatcctct atcctttttt cctttcctga tcaaggtgct cttctcattt tttcctgaga accttagcca tcagatgagg 240 300 360 403 60 120 180 240 300 98677.doc -122 -360 200533758 ctccttagtt tattgtggtt ggttgttttt tctttataat ggctctgggc tatatgccca tatttataaa ccagcagcag gggaaagatt atattttata agagggaaca aattttcaca atttgaaaga ngg cccacataag ttttctcttt tnnnnnnnnnnnnnnn nnnnnnnnnn

&lt;210〉 165 &lt;211&gt; 568 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 34288__at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 39, 41..43, 45, 394..418, 428..443, 493..512 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 165 tttgcaacag gcagagctgt gtcgcacagc agtgctgtnc nnnanagcca gctgaggaca&lt; 210> 165 &lt; 211 &gt; 568 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 34288__at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 39, 41. .43, 45, 394..418, 428..443, 493..512 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 165 tttgcaacag gcagagctgt gtcgcacagc agtgctgtnc nnnanagcca gctgaggaca

ggcttgcctg gacttctgta agataggatt ttctgtgttt cctgaatttt ttatatggtg atttgtattt aaattttaag actttatttt ctcactattg gtgtacctta taaatgtatt tgaaagttaa atatatttta aatattgttt gggaggcata gtgctgacat atattcagag tgttgtagtt ttaaggttag cgtgacttca gttttgacta aggatgacac taattgttag ctgttttgaa attatatata tataaatata tataaatata taaatatatg ccagtcttgg ctgaaatgtt ttatttacca tagttttata tctnnnnnnn nnnnnnnnnn nnnnnnnnat 98677.doc -123 - 200533758 atggaacnnn nnnnnnnnnn nnntgcagtt tgtgacatta atagtattgt aaagttacat tttaaaataa acnnnnnnnn nnnnnnnnnn nnaaatctgc acacacaacg aacagttgca tttcagagag ttctctcaat ttgtaagt &lt;210〉 166 &lt;211&gt; 353 &lt;212〉 DNA &lt;213〉人類ggcttgcctg gacttctgta agataggatt ttctgtgttt cctgaatttt ttatatggtg atttgtattt aaattttaag actttatttt ctcactattg gtgtacctta taaatgtatt tgaaagttaa atatatttta aatattgttt gggaggcata gtgctgacat atattcagag tgttgtagtt ttaaggttag cgtgacttca gttttgacta aggatgacac taattgttag ctgttttgaa attatatata tataaatata tataaatata taaatatatg ccagtcttgg ctgaaatgtt ttatttacca tagttttata tctnnnnnnn nnnnnnnnnn nnnnnnnnat 98677.doc -123 - 200533758 atggaacnnn nnnnnnnnnn nnntgcagtt tgtgacatta atagtattgt aaagttacat tttaaaataa acnnnnnnnn nnnnnnnnnn nnaaatctgc acacacaacg aacagttgca tttcagagag ttctctcaat ttgtaagt &lt; 210〉 166 &lt; 211 &gt; 353 &lt; 212〉 DNA &lt; 213〉 human

&lt;220&gt; &lt;223&gt; Probe 34304_s_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （139)..(166) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 166 agtacttgct aaaaatggca acagaggagt gaggagtgct gctgtagatg acaacctcca ttctatttta gaataaattc ccaacttctc ttgctttcta tgctgtttgt agtgaaataa&lt; 220 &gt; &lt; 223 &gt; Probe 34304_s_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (139) .. (166) &lt; 223 &gt; n is a, g, c or t &lt; 400 〉 166 agtacttgct aaaaatggca acagaggagt gaggagtgct gctgtagatg acaacctcca ttctatttta gaataaattc ccaacttctc ttgctttcta tgctgtttgt agtgaaataa

tagaatgagc acccattcnn nnnnnnnnnn nnnnnnnnnn nnnnnncatg tttgaaatga ggtctgttta aagtggcaat ctcagatgca gtttggagag tcagatcttt ctccttgaat atctttcgat aaacaacaag gtggtgtgat cttaatatat ttgaaaaaaa cttcattctc gtgagtcatt taaatgtgta caatgtacac actggtactt agagtttctg ttttagaatgagc acccattcnn nnnnnnnnnn nnnnnnnnnn nnnnnncatg tttgaaatga ggtctgttta aagtggcaat ctcagatgca gtttggagag tcagatcttt ctccttgaat atctttcgat aaacaacaag gtggtgtgat cttaatacat tatgat tttgat

&lt;210〉 167 &lt;211&gt; 508 &lt;212&gt; DNA 98677.doc -124-&lt; 210> 167 &lt; 211 &gt; 508 &lt; 212 &gt; DNA 98677.doc -124-

200533758 &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 34375—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; (33)..(33) &lt;223〉n 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （189)..(189) &lt;223&gt; n 為 a, g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (199)..(199) &lt;223〉n 為 a，g，c 或 t &lt;400〉 167 ccagatgcaa tcaatgcccc agtcacctgc tgntataact tcaccaatag gaagatctca gtgcagaggc tcgcgagcta tagaagaatc accagcagca agtgtcccaa agaagctgtg atcttcaaga ccattgtggc caaggagatc tgtgctgacc ccaagcagaa gtgggttcag gattccatng gaccacctng gacaagcaaa cccaaactcc gaagacttga acactcactc cacaacccaa gaatctgcag ctaacttatt ttcccctagc tttccccaga caccctgttt tattttatta taatgaattt tgtttgttga tgtgaaacat tatgccttaa gtaatgttaa ttcttattta agttattgat gttttaagtt tatctttcat ggtactagtg ttttttagat 60 120 180 240 300 360 98677.doc -125· 420 480 200533758 508 acagagactt ggggaaattg cttttcctct tgaaccacag ttctacccct gggatgtttt gagggtcttt gcaagaatca ttaataca &lt;210〉 168 &lt;211&gt; 530 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 34390_at HG-U95Av2200533758 &lt; 213〉 Human &lt; 220〉 &lt; 223 &gt; Probe 34375-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc ^ feature &lt; 222 &gt; (33) .. (33) &lt; 223〉 n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (189) .. (189) &lt; 223 &gt; n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (199) .. (199) &lt; 223> n is a, g, c or t &lt; 400> 167 ccagatgcaa tcaatgcccc agtcacctgc tgntataact tcaccaatag gaagatctca gtgcagaggc tcgcgagcta tagaagaatc accagcagca agtgtcccaa agaagctgtg atcttcaaga ccattgtggc caaggagatc tgtgctgacc ccaagcagaa gtgggttcag gattccatng gaccacctng gacaagcaaa cccaaactcc gaagacttga acactcactc cacaacccaa gaatctgcag ctaacttatt ttcccctagc tttccccaga caccctgttt tattttatta taatgaattt tgtttgttga tgtgaaacat tatgccttaa gtaatgttaa ttcttattta agttattgat gttttaagtt tatctttcat ggtactagtg ttttttagat 60 120 180 240 300 360 98677.doc -125 · 420 480 200533758 508 acagagactt ggggaaattg cttttcctct tgaaccacag ttctacccct gggatgtttt gagggtcttt gcaagaatca ttaataca &lt; 210 168 &lt; 211 &gt; 530 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 34390_at HG-U95Av2

&lt;221&gt; misc__feature &lt;222&gt; 34, 39, 40, 44, 464..478 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 168 gtacagctgt gttctggtac aacctcttgc ggancgggnn aagntgacta ccgaacaaga catgctgcct gccctgtgct tgtgggctgc aagtgggtct ccaataagtg gttccatgaa cgaggacagg agttcttgag accttgtgga tcaacagaag ttgactgaca tccttttctg tccttcccct tcctggtcct tcagcccatg tcaacgtgac agacaccttt gtatgttcct ttgtatgttc ctatcaggct gatttttgga gaaatgaatg tttgtctgga gcagagggag accatactag ggcgactcct gtgtgactga agtcccagcc cttccattca gcctgtgcca tccctggccc caaggctagg atcaaagtgg ctgcagcaga gttagctgtc tagcgcctag caaggtgcct ttgtacctca ggtgttttag gtgtgagatg tttnnnnnnn nnnnnnnnct gataccttgt ttacatgttt gtttttatgg catttctatc tattgtggct 60 120 180 240 300 360 420 480 530 98677.doc -126 - 200533758 &lt;210&gt; 169 &lt;211&gt; 404 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223〉 Probe 34432—at HG-U95Av2 &lt;220〉&lt; 221 &gt; misc__feature &lt; 222 &gt; 34, 39, 40, 44, 464..478 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 168 gtacagctgt gttctggtac aacctcttgc ggancgggnn aagntgacta ccgctgctggctggctggctgctgctgctgctgctgctgctgcgctgct gttccatgaa cgaggacagg agttcttgag accttgtgga tcaacagaag ttgactgaca tccttttctg tccttcccct tcctggtcct tcagcccatg tcaacgtgac agacaccttt gtatgttcct ttgtatgttc ctatcaggct gatttttgga gaaatgaatg tttgtctgga gcagagggag accatactag ggcgactcct gtgtgactga agtcccagcc cttccattca gcctgtgcca tccctggccc caaggctagg atcaaagtgg ctgcagcaga gttagctgtc tagcgcctag caaggtgcct ttgtacctca ggtgttttag gtgtgagatg tttnnnnnnn nnnnnnnnct gataccttgt ttacatgttt gtttttatgg catttctatc tattgtggct 60 120 180 240 300 360 420 480 530 98677.doc -126-200533758 &lt; 210 &gt; 169 &lt; 211 &gt; 404 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 34432-at HG-U95Av2 &lt; 220〉

&lt;221&gt; misc—feature &lt;222〉 （218)..(218) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 169 60 120 180 240 300 360 404 caggtggctc ccagctgcat tctgagaact ctgtgattgg gcaaggccct cccctgcccc accagccccc acccgcctgg agacacaccc tcccccacaa tctttctaga caggtgcttc aggacagagg acaggcatgg cttccccttg ggcctcctca gtaggcggtc tggcctgacc cccaacaaag aagcctggag gtcagagaag caaatgcnga gcctgctccc tcctaagaag atcccaagaa tccaatggct cagtccttgg tgatctaaga cagcaaagaa gtgtgcaagg&lt; 221 &gt; misc—feature &lt; 222〉 (218) .. (218) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 169 60 120 180 240 300 360 404 caggtggctc ccagctgcat tctgagaact ctgtgattgg gcaaggccct cccctgcccc accagccccc acccgcctgg agacacaccc tcccccacaa tctttctaga caggtgcttc aggacagagg acaggcatgg cttccccttg ggcctcctca gtaggcggtc tggcctgacc cccaacaaag tagcctccgcc tccccgggt

agggccctgt tagctcccac tgtcctggtt tctcctcctg gagtctaatt tccttggccc tctgagcctt ttgagtctgg gccctggtcc aatgctgctg ttgt &lt;210〉 170 &lt;211&gt; 76 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 34636—at HG-U95Av2 98677.doc -127- 60 200533758 &lt;400&gt; 170 76 tagaggggca ccttttcatg gtctctgcac ccagtgaaca cattttactc tagaggcatc acctgggacc ttactc &lt;210〉 171 &lt;211〉 444 &lt;212〉 DNA &lt;213&gt;人類agggccctgt tagctcccac tgtcctggtt tctcctcctg gagtctaatt tccttggccc tctgagcctt ttgagtctgg gccctggtcc aatgctgctg ttgt &lt; 210> 170 &lt; 211 &gt; 76 &lt; 212 &gt; DNA &lt; 213 &gt; UTF-9 &lt; HG &lt; 658 &lt; U &lt; 218 &gt; Ult &lt; 212 127- 60 200533758 &lt; 400 &gt; 170 76 tagaggggca ccttttcatg gtctctgcac ccagtgaaca cattttactc tagaggcatc acctgggacc ttactc &lt; 210〉 171 &lt; 211〉 444 &lt; 212〉 DNA &lt; 213 &gt; human

&lt;220〉 &lt;223&gt; Probe 34666_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 129， 135， 136， 140， 142， 147, 149 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 171 60 120 180 240 300 360 420 tgctctattg tagcatttct tgatgttgct tagtcactta tttcataaac aacttaatgt tctgaataat ttcttactaa acattttgtt attgggcaag tgattgaaaa tagtaaatgc&lt; 220> &lt; 223 &gt; Probe 34666_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222> 129, 135, 136, 140, 142, 147, 149 &lt; 223 &gt; n is a, g , C or t &lt; 400〉 171 60 120 180 240 300 360 420 tgctctattg tagcatttct tgatgttgct tagtcactta tttcataaac aacttaatgt tctgaataat ttcttactaa acattttgtt attgggcaag tgattgaaaa tagtaaatgc

tttgtgtgna ttgannctgn anttggncna ttttcttcag agagctaaat tacaattgtc atttataaaa ccatcaaaaa tattccatcc atatactttg gggacttgta gggatgcctt tctagtccta ttctattgca gttatagaaa atctagtctt ttgccccagt tacttaaaaa taaaatatta acactttccc aagggaaaca ctcggctttc tatagaaaat tgcacttttt gtcgagtaat cctctgcagt gatacttctg gtagatgtca cccagtggtt tttgttaggt caaatgttcc tgtatagttt ttgc 986~7.doc -128- 444 200533758 &lt;210〉 172 &lt;211&gt; 521 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 34678一at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc一featuretttgtgtgna ttgannctgn anttggncna ttttcttcag agagctaaat tacaattgtc atttataaaa ccatcaaaaa tattccatcc atatactttg gggacttgta gggatgcctt tctagtccta ttctattgca gttatagaaa atctagtctt ttgccccagt tacttaaaaa taaaatatta acactttccc aagggaaaca ctcggctttc tatagaaaat tgcacttttt gtcgagtaat cctctgcagt gatacttctg gtagatgtca cccagtggtt tttgttaggt caaatgttcc tgtatagttt ttgc 986 ~ 7.doc -128- 444 200533758 &lt; 210> 172 &lt; 211 &gt; 521 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 34678-at HG-U95Av2 &lt; 220> &lt; 221 &gt; mi sc-feature

&lt;222&gt; 158, 161..164, 166..171, 173..177, 179..186, 188..191 &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 193..198, 200..214, 218..234, 432..454, 457..491 &lt;223&gt; η 為 a，g，c 或 t &lt;400&gt; 172 ccgaactatt tgtcaatgaa gattgtaaag ccaaatgtgt aacaaaggca aaggcttcat 60 ttcaagagtc atccagcaat gagagaatcc tgcctctgta gaccaacatc cagtgtgatt 120 ttgtgtctga gaccacaccc cagtagcagg ttacgccntg nnnncnnnnn ncnnnnntnn 180 nnnnnngnnn ntnnnnnncn nnnnnnnnnn nnnnaacnnn nnnnnnnnnn nnnntgttat 240 ctcttaagta ttaaaagttt tattttctaa agtttaaatc atgtttttca aaatattttt 300 caaggtggct ggttccattt aaaaatcatc tttttatatg tgtcttcggt tctagacttc 360 agcttttgga aattgctaaa tagaattcaa aaatctctgc atcctgaggt gatatacttc 420 atatttgtaa tnnnnnnnnn nnnnnnnnnn nnnnaannnn nnnnnnnnnn nnnnnnnnnn 480 nnnnnnnnnn ngcccacaac cattgctata ttttgtatgg a 521 98677.doc -129- 200533758 &lt;210〉 173 &lt;211〉 455 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 34690_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc^feature &lt;222〉 120·.139, 340·.343, 345..348, 366, 375&lt; 222 &gt; 158, 161..164, 166..171, 173..177, 179..186, 188..191 &lt; 223 &gt; η is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 193..198, 200..214, 218..234, 432..454, 457..491 &lt; 223 &gt; η is a, g, c or t &lt; 400 &gt; 172 ccgaactatt tgtcaatgaa gattgtaaag ccaaatgtgt aacaaaggca aaggcttcat 60 ttcaagagtc atccagcaat gagagaatcc tgcctctgta gaccaacatc cagtgtgatt 120 ttgtgtctga gaccacaccc cagtagcagg ttacgccntg nnnncnnnnn ncnnnnntnn 180 nnnnnngnnn ntnnnnnncn nnnnnnnnnn nnnnaacnnn nnnnnnnnnn nnnntgttat 240 ctcttaagta ttaaaagttt tattttctaa agtttaaatc atgtttttca aaatattttt 300 caaggtggct ggttccattt aaaaatcatc tttttatatg tgtcttcggt tctagacttc 360 agcttttgga aattgctaaa tagaattcaa aaatctctgc atcctgaggt gatatacttc 420 atatttgtaa tnnnnnnnnn nnnnnnnnnn nnnnaannnn nnnnnnnnnn nnnnnnnnnn 480 nnnnnnnnnnnn ngcccacaac cattgctata ttttgtatgg a 521 98677.doc -129- 200533758 &lt; 210〉 173 &lt; 211〉 455 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &HG; &lt; 223 95Av2 &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222〉 120 · .139, 340 · .343, 345..348, 366, 375

&lt;223〉η 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; mi sc一feature &lt;222&gt; 385, 409, 420, 428 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 173 ttaaaaagcc acattggagc tcccttctac ttgaggggga gtgagtttta ggaaagggga nnnnnnnnnn nnnnnnnnnt ctctccccaa aactcccctc ccccacccta cgctgagctt ctgcggcttc ctcattgttg ctgttttagg ctctgaatgt cagttttgtt tttaaaagtc tttggngggg aaaancctaa tttcngggga gggcactngg gggctgttct ccttccttcc ccactaaaaa ataaccaatt tttacatttt attaagattc cagggagagc tctggggatn gccccttttt agtgactaag tcaaggcccc attcgagttc attcgtacta ataatccctc ccaccccagc tcagccaatg attcctttcc acttgcttan nnnannnnag cgtatgtgta tttctgtggt aggtaatang gagaagaaan ctggg 60 120 180 240 300 360 420 98677.doc -130 - 455 200533758 &lt;210〉 174 &lt;211&gt; 549 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 34720_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature&lt; 223> η is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222 &gt; 385, 409, 420, 428 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 173 ttaaaaagcc acattggagc tcccttctac ttgaggggga gtgagtttta ggaaagggga nnnnnnnnnn nnnnnnnnnt ctctccccaa aactcccctc ccccacccta cgctgagctt ctgcggcttc ctcattgttg ctgttttagg ctctgaatgt cagttttgtt tttaaaagtc tttggngggg aaaancctaa tttcngggga gggcactngg gggctgttct ccttccttcc ccactaaaaa ataaccaatt tttacatttt attaagattc cagggagagc tctggggatn gccccttttt agtgactaag tcaaggcccc attcgagttc attcgtacta ataatccctc ccaccccagc tcagccaatg attcctttcc acttgcttan nnnannnnag cgtatgtgta tttctgtggt aggtaatang gagaagaaan ctggg 60 120 180 240 300 360 420 98677.doc -130-455 200533758 &lt; 210〉 174 &lt; 211 &gt; 549 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 34720_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc-feature

&lt;222&gt; 35, 38..73, 118..140, 264..305, 458, 476..480, 483, 485 &lt;223&gt; η 為 a, g，c 或 t &lt;220&gt; &lt;221〉 misc_feature &lt;222&gt; 488..490, 492, 494..499, 501..504, 506..512, 514..516 &lt;223&gt; n 為 a，g，c 或 t&lt; 222 &gt; 35, 38..73, 118..140, 264..305, 458, 476..480, 483, 485 &lt; 223 &gt; η is a, g, c or t &lt; 220 &gt; &lt; 221〉 misc_feature &lt; 222 &gt; 488..490, 492, 494..499, 501..504, 506..512, 514..516 &lt; 223 &gt; n is a, g, c or t

&lt;400〉 174 tctcaccaac nnnnnnnnnn nnnnnnnnnn taacccagtt ggaaaaaaac nnnnnctctg aacagaggca tcagcccttg ttntnttnnn gaaggctagg nnncactctg nnnnnnnnnn tgaaatctta agtttgaaca catgcaacag agtgcaattt gactctaaat cncnnnnnnt aggcggcgtc atttctaaaa ttattaaatt aaaaaagaaa caannnnnnn taaaaattaa ataaatttat tgaggggatt nnnngnnnnn agagntgnnn gttaaaaaaa tcggccctta aaatgaaaaa nnnnnnnnnn tataatattt atctaaaggg aaaaagantt nnannncatt nnnnnnnnnn atatatgaaa acccagcctt aaaaggaaaa nnnnnnnnnn tccccacaaa gaatcatgat taaaataatt aattcaagac nnnnnnnnnn tctctgtnnn ttccagtgtg aaagaaaaaa nnnnnnnnnn agaaacactt tataagtcct ttgaannnnn aaatccatgt 60 120 180 240 300 360 420 480 540 98677.doc -131 - 549 200533758 ggcttgagg &lt;210〉 175 &lt;211〉 573 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 34748_at HG-U95Av2&Lt; 400> 174 tctcaccaac nnnnnnnnnn nnnnnnnnnn taacccagtt ggaaaaaaac nnnnnctctg aacagaggca tcagcccttg ttntnttnnn gaaggctagg nnncactctg nnnnnnnnnn tgaaatctta agtttgaaca catgcaacag agtgcaattt gactctaaat cncnnnnnnt aggcggcgtc atttctaaaa ttattaaatt aaaaaagaaa caannnnnnn taaaaattaa ataaatttat tgaggggatt nnnngnnnnn agagntgnnn gttaaaaaaa tcggccctta aaatgaaaaa nnnnnnnnnn tataatattt atctaaaggg aaaaagantt nnannncatt nnnnnnnnnn atatatgaaa acccagcctt aaaaggaaaa nnnnnnnnnn tccccacaaa gaatcatgat taaaataatt aattcaagac nnnnnnnnnn tctctgtnnn ttccagtgtg aaagaaaaaa nnnnnnnnnn agaaacactt tataagtcct ttgaannnnn aaatccatgt 60 120 180 240 300 360 420 480 540 98677.doc -131-549 200533758 ggcttgagg &lt; 210> 175 &lt; 211> <lt; 211> 〉 &Lt; 223 &gt; Probe 34748_at HG-U95Av2

&lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (85)..(85) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; (87)..(104) &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （160)..(174) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （348)..(348) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc feature 98677.doc -132- 60 60&lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (85) .. (85) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; (87) .. (104) &lt; 223〉 n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 (160) .. (174) &lt; 223> n is a, g , C or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (348) .. (348) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc feature 98677. doc -132- 60 60

200533758 &lt;222〉 （489)..(489) &lt;223〉η 為 a, g，c 或 &lt;400&gt; 175 tgctcagcaa aattgttgag tacctgttct gggcaggtcc cacgctatat gcacaaagtt aagaaaaact tggtcttagc ccttngnnnn nnnnnnnnnn nnnngggcat taaggcaaag tagttccagt gatttaaaat acggttccaa atacgctaan nnnnnnnnnn nnnnaccaga tttacagatt ggaaatactg cagatgatgt gaagttatca gttggaggag ctgtgattaa gctggataat aagagaacgt gccatctgta aagcactcag aaggcagcca tccctagatg ttggtttcat gtatattaca ctatctacta ctatccataa atgcaatnat atgcatgtta acaacattaa aaacagcaaa cagcaatcta agtacagaaa agctttttgt gtgtttaaaa aaattgaaga aaattcagga agaaacgtgt taataaacat tgtactgttc ttttgcttct caaaggaant attcacttgc cactttggtt atttttgagt tttcgtacat aggaagtttt atattgccag ccttcctgtg ataaagatat taa &lt;210&gt; 176 &lt;211〉 281 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 34759_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc—feature &lt;222〉 （128)..(197) &lt;223&gt; n 為 a，g，c 或 t 120 180 240 300 360 420 480 540 573 98677.doc -133- 200533758 &lt;400〉 176 caaattgcca tgttatggtt gtgattatga aacttatatg agatgtgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntta caaagctgtt cctacctcac ctgccttgaa acagcacaat ttgtgttgtt ttgtgtcttc nnnnnnnnnn nnnnnnnnnn cctaactttt tgtatgtttt catgaggctt tatggattgt gaagtgtatc agtatattct tgttgcctgt cctttgggcc nnnnnnnnnn nnnnnnnnnn catgactgtg tgttattttc &lt;210〉 177 &lt;211&gt; 538 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 34760_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 294, 296, 299..303, 509, 510 H &lt;223〉n 為 a，g，c 或 t &lt;400〉 177 cttgtagtga gcagtgtatg gtctcttttg ttcagaattt aaaactgata accaatgaaa gccttttctc ttattcctct accgtcattt acatgataat ctgaagctaa tatgacaata tttaaatact aagtggtact agggaactac aagaatactg taaagcttaa gccattgtta tcactgtcat ttagcattta ataacaaaac tatacagaat tatgtgcata ccaatgaatg ttttgtacca tctagttaaa ttttttaaat aaagttttat gggttaagca gaananaann 98677.doc -134- 200533758 nnnatactga acagaatata caaaggtaac gagatttgaa attttattaa ttaaaactac tggcaagagg attgtaataa aagtatatat cacccttaaa tgagcaaatg aattcttgnn acttcaaatt ttttatattt ttttagaaca tatgaagtct caaagcatcc ttgctttaag tttatattat gatgtcttct cttaggaccc acagacaatg tgcttaaaat ctgagcac200533758 &lt; 222> (489) .. (489) &lt; 223> η is a, g, c, or &lt; 400 &gt; 175 tgctcagcaa aattgttgag tacctgttct gggcaggtcc cacgctatat gcacaaagtt aagaaaaact tggtcttagc ccttngnnnn nnnnnnnnnn nnnngggcat taaggcaaag tagttccagt gatttaaaat acggttccaa atacgctaan nnnnnnnnnn nnnnaccaga tttacagatt ggaaatactg cagatgatgt gaagttatca gttggaggag ctgtgattaa gctggataat aagagaacgt gccatctgta aagcactcag aaggcagcca tccctagatg ttggtttcat gtatattaca ctatctacta ctatccataa atgcaatnat atgcatgtta acaacattaa aaacagcaaa cagcaatcta agtacagaaa agctttttgt gtgtttaaaa aaattgaaga aaattcagga agaaacgtgt taataaacat tgtactgttc ttttgcttct caaaggaant attcacttgc cactttggtt atttttgagt tttcgtacat aggaagtttt atattgccag ccttcctgtg ataaagatat taa &lt; 210 &gt; 176 &lt; 211> 281 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 34759_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> (128): (197) &lt; 223 &gt; n is a, g, c or t 120 180 240 300 360 420 480 540 573 98677.doc -133- 200533758 &lt; 400〉 176 caaattgcca tgttatggtt gtgattatga aacttatatg agatgtgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntta caaagctgtt cctacctcac ctgccttgaa acagcacaat ttgtgttgtt ttgtgtcttc nnnnnnnnnn nnnnnnnnnn cctaactttt tgtatgtttt catgaggctt tatggattgt gaagtgtatc agtatattct tgttgcctgt cctttgggcc nnnnnnnnnn nnnnnnnnnn catgactgtg tgttattttc &lt; 210> 177 &lt; 211 &gt; 538 &lt; 212> DNA &lt; 213> Human &lt; 220〉 &lt; 223 &gt; Probe 34760_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 294, 296, 299..303, 509, 510 H &lt; 223> n is a, g, c or t &lt; 400> 177 cttgtagtga gcagtgtatg gtctcttttg ttcagaattt aaaactgata accaatgaaa gccttttctc ttattcctct accgtcattt acatgataat ctgaagctaa tatgacaata tttaaatact aagtggtact agggaactac aagaatactg taaagcttaa gccattgtta tcactgtcat ttagcattta ataacaaaac tatacagaat tatgtgcata ccaatgaatg ttttgtacca tctagttaaa ttttttaaat aaagttttat gggttaagca gaananaann 98677.doc -134- 200533758 nnnatactga acagaatata caaaggtaac gagatttgaa attttattaa ttaaaactac tggcaagagg attgtaataa aagtatata t cacccttaaa tgagcaaatg aattcttgnn acttcaaatt ttttatattt ttttagaaca tatgaagtct caaagcatcc ttgctttaag tttatattat gatgtcttct cttaggaccc acagacaatg tgcttaaaat ctgagcac

&lt;210〉 178 &lt;211&gt; 428 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 34876—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 222, 228, 241..244, 266..303 &lt;223〉n 為 a，g，c 或 t&lt; 210〉 178 &lt; 211 &gt; 428 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 34876--at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 222, 228, 241..244, 266..303 &lt; 223> n is a, g, c or t

&lt;400〉 178 tgaggtgccc tgccttcaaa agtcaatttg taaacagatc nnnnctcata nnntatttag tatcacctat aacacccatt atgaaatttt taatttatgt tactaatcct atcttttttc tttttctgcc ggaatgtttc catctcaagt taaaagggac gaaatctaac gtataaaagt agatgnnnnn tatgctagtg tgtatttatg gcttcagtct tttaaatgaa tgtaatgagg tattttacga nnnnnnnnnn gaaaaatagt aattgactca ttggtttatt gttgaatagt tcctttctgt anaaaaanaa nnnnnnnnnn accaggatca aaagaaagct tcatgcactg agtttttaaa tttttatatg aaaaaaaaaa nnnnnnnnnn gaatacaggg ttgtttctga 98677.doc -135 - 428 200533758 aatcgcat &lt;210&gt; 179 &lt;211&gt; 337 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 34886_at HG-U95Av2ttgtttctga 98677.doc 400> 178 tgaggtgccc tgccttcaaa agtcaatttg taaacagatc nnnnctcata nnntatttag tatcacctat aacacccatt atgaaatttt taatttatgt tactaatcct atcttttttc tttttctgcc ggaatgtttc catctcaagt taaaagggac gaaatctaac gtataaaagt agatgnnnnn tatgctagtg tgtatttatg gcttcagtct tttaaatgaa tgtaatgagg tattttacga nnnnnnnnnn gaaaaatagt aattgactca ttggtttatt gttgaatagt tcctttctgt anaaaaanaa nnnnnnnnnn accaggatca aaagaaagct tcatgcactg agtttttaaa tttttatatg aaaaaaaaaa nnnnnnnnnn gaatacaggg; & lt -135-428 200533758 aatcgcat &lt; 210 &gt; 179 &lt; 211 &gt; 337 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 34886_at HG-U95Av2

&lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （197)..(216) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 179 60 120 180 240 300 337 atcatacaga tcaggcagtg tttaaaatga tggtaggtag cacagtggac agtctttgat catcatgtag aatatggcta tgaatcagga aagagattag aacatttaat aatgtatgta cagctggtgc ttagtttttt tttaatctaa atttaattac cttattggat atttgatatt tggttattta atcacannnn nnnnnnnnnn nnnnnnctga ttggtgtttt atctcctgtg atcctttgat ggcttttttt gcctaccatt tcacagaggt ttagacagca gtagtagctc cctaggagag tttactgatg aaacagcctc tgcaaga &lt;210&gt; 180 &lt;211&gt; 528 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; 98677.doc -136-&lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (197) .. (216) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 179 60 120 180 240 300 337 atcatacaga tcaggcagtg tttaaaatga tggtaggtag cacagtggac agtctttgat catcatgtag aatatggcta tgaatcagga aagagattag aacatttaat aatgtatgta cagctggtgc ttagtttttt tttaatctaa atttaattac cttattggat atttgatatt tggttattta atcacannnn nnnnnnnnnn nnnnnnctga ttggtgtttt atctcctgtg atcctttgat ggcttttttt gcctaccatt tcacagaggt ttagacagca gtagtagctc cctaggagag tttactgatg aaacagcctc tgcaaga &lt; 210 &gt; 180 &lt; 211 &gt; 528 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; 98677.doc -136-

200533758 &lt;223〉 Probe 34887—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; 361..367, 371..374, 376, 377, 379..383, 385..387, 499 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 180 gcactaccat agctacatca gtttgataca gtattgaaaa attatcagtt atattttgct gtttatgatc tatttgtaga ttaggattaa aatggattta atccattttt aaggctgtgt gaatttttct aaacaagaac catttgcaat atggatttct tagagattaa accaattata acttattagc agtcgcgagc acatgttcat atagtcaatg taaaaataca ctaatgagta tttggtaaat cccagtaggc ttttaccatt agcataattt tgtgttgtac aattaagtta caattacatc tctaattttg gataatattc attggttaac aataaagtga caaaagctca nnnnnnnaaa nnnnanngnn nnnannnaac atggattttt tgtatgtttc ttgaaaatta caatctttat cacagccatg aatcaccaca acttaaaagt aagaagtaga taggaaataa ttttaaatcc tcatagatnt actctttccc cgatacctct ttggtatg &lt;210&gt; 181 &lt;211&gt; 376 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 34916_s_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc feature 60 120 180 240 300 360 420 480 528 98677 doc •137- 60 200533758 &lt;222&gt; 203, 205..207, 212..287, 319, 325 &lt;223&gt; η 為 a，g，c 或 t &lt;400&gt; 181200533758 &lt; 223〉 Probe 34887-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 361..367, 371..374, 376, 377, 379..383, 385..387 , 499 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 180 gcactaccat agctacatca gtttgataca gtattgaaaa attatcagtt atattttgct gtttatgatc tatttgtaga ttaggattaa aatggattta atccattttt aaggctgtgt gaatttttct aaacaagaac catttgcaat atggatttct tagagattaa accaattata acttattagc agtcgcgagc acatgttcat atagtcaatg taaaaataca ctaatgagta tttggtaaat cccagtaggc ttttaccatt agcataattt tgtgttgtac aattaagtta caattacatc tctaattttg gataatattc attggttaac aataaagtga caaaagctca nnnnnnnaaa nnnnanngnn nnnannnaac atggattttt tgtatgtttc ttgaaaatta caatctttat cacagccatg aatcaccaca acttaaaagt aagaagtaga taggaaataa ttttaaatcc tcatagatnt actctttccc cgatacctct ttggtatg &lt; 210 &gt; 181 &lt; 211 &gt; 376 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 34916_s_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc feature 60 120 180 240 300 360 420 480 528 98677 doc • 137- 60 200533758 &lt; 222 &gt; 203, 205..207, 212..287, 319, 325 &lt; 223 &gt; η is a, g, c or t &lt; 400 &gt; 181

120 180 240 300 360 376 ccaactgcac cttggctggg aagcacaccc tgcagccggc cagcaatagc tcggacgcaa tctgtgagga cagggacccc ccagccacgc agccccagga gacccagggc cccccggcca ggcccatcac tgtccagccc actgaagcct ggcccagaac ctcacaggga ccctccaccc ggcccgtgga ggtccccggg ggncnnncgg tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncgg agggaccaga ggctgccccc cgatgcccna caagncccct gggggaggca gtttccggac ccccatccaa gaggagcagg ccgacg &lt;210〉 182 &lt;211&gt; 363 &lt;212〉 DNA &lt;213&gt;人類 • &lt;220&gt; &lt;223&gt; Probe 34975一at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （46).,(46) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 182 60 cagatctgtc atgtatccct aaaaggaggg agctggccac tggctnttgg gaaagccatg agtatatagt tagcaaatac tgaactttct cagatatggc attagatgca agacaacctc 98677.doc -138- 120 200533758 ctagggattg atttaaagac atggaaacta ttttcatatg tgt atgcctaact cagatctaag atgctgccac atattctgag gatggattct caaattttga tctcatcccc ctaatctgat ctttgagact aatagatgtt gtcccaacca aaaatctatg atttagatat tgttttttgt tctctgtcaa ccaatatata tatgtgagca atttctcagt aaatatacct ctattgcttg 180 240 300 360 363120 180 240 300 360 376 ccaactgcac cttggctggg aagcacaccc tgcagccggc cagcaatagc tcggacgcaa tctgtgagga cagggacccc ccagccacgc agccccagga gacccagggc cccccggcca ggcccatcac tgtccagccc actgaagcct ggcccagaac ctcacaggga ccctccaccc ggcccgtgga ggtccccggg ggncnnncgg tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncgg agggaccaga ggctgccccc cgatgcccna caagncccct gggggaggca gtttccggac ccccatccaa gaggagcagg ccgacg &lt; 210> 182 &lt; 211 &gt; 363 &lt; 212〉 DNA &lt; 213 &gt; human • &lt; 220 &gt; &lt; 223 &gt; Probe 34975-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 (46)., (46) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 182 60 cagatctgtc atgtatccct aaaaggaggg agctggccac tggctnttgg gaaagccatg agtatatagt tagcaaatac tgaactttct cagatatggc attagatgca agacaacctc 98677.doc -138- 120 200533758 ctagggattg atttaaagac atggaaacta ttttcatatg tgt atgcctaact cagatctaag atgctgccac atattctgag gatggattct caaattttga tctcatcccc ctaatctgat ctttgagact aatagatgtt gtcccaac ca aaaatctatg atttagatat tgttttttgt tctctgtcaa ccaatatata tatgtgagca atttctcagt aaatatacct ctattgcttg 180 240 300 360 363

&lt;210&gt; 183 &lt;211&gt; 411 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35017—fjt HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 82， 102， 107， 108， 134, 323 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 183 tacctggagg gcacctgcat ggagtggctc cgcagacacc tggagaacgg gaaggagacg ctgcagcgcg cggacccccc cnaagacaca cgtgacccac cnccctnnct ctgaacatga ggcataacga ggtnctgggt tctgggcttc taccctgcgg agatcacatt gacctggcag cgggatgggg aggaccagac ccaggacatg gagctcgtgg agaccaggcc cacaggggat ggaaccttcc agaagtgggc ggttgtggta gtgccttctg gagaggaaca gagatacaca tgccatgtgc agcacaaggg gcntgcccaa gcccctcatc ctgagatggg agccctctcc 60 120 180 240 300 98677.doc -139- 360 200533758 ccagcccacc atccccattg tgggtatcat tgctggcctg gttctccttg g &lt;210&gt; 184 &lt;211&gt; 545 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35025一at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （226)..(265) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 184 tttctggagg tctctgaacc cagggaagac aagaaggaaa gattttgttg ttgtttgttt atttggtttc cccagtagtt agctttcttc cctggattcc tcacttttga agagtgtgag gaaaacctat gtttggcgct taagctttca gctcagctta atgaagtgtt tagcatagta cctctgctat ttgctgttat tttatctgct atgctattga agtttnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntaatc ttacaaagtg tcttggaatt gtaggtgact attatttttc caagaaatat cccttaagat attaactgag aaggctgggg gtttaatgtg gaaatgatgt ttcaaaagga atcctgtgat ggaaatacaa ctggtatctt cactttttta ggaattggga aatattttaa tgtttcttgg ggaatatgtt agagaattcc cttactcttg attgtgggat actatttaat tatttcactt tagaaagctg agtgtttcac accttatcta tgtag 411&lt; 210 &gt; 183 &lt; 211 &gt; 411 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 35017—fjt HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 82, 102, 107, 108, 134, 323 &lt; 223 &gt; n is a, g, c or t &lt; 400> 183 tacctggagg gcacctgcat ggagtggctc cgcagacacc tggagaacgg gaaggagacg ctgcagcgcg cggacccccc cnaagacaca cgtgacccac cnccctnnct ctgaacatga ggcataacga ggtnctgggt tctgggcttc taccctgcgg agatcacatt gacctggcag cgggatgggg aggaccagac ccaggacatg gagctcgtgg agaccaggcc cacaggggat ggaaccttcc agaagtgggc ggttgtggta gtgccttctg gagaggaaca gagatacaca tgccatgtgc agcacaaggg gcntgcccaa gcccctcatc ctgagatggg agccctctcc 60 120 180 240 300 98677.doc -139- 360 200533758 ccagcccacc atccccattg tgggtatcat tgctggcctg gttctccttg g &lt; 210 &gt; 184 &lt; 211 &gt; 545 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 35025-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (226) .. (265) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 184 tttctggagg tctctgaac c cagggaagac aagaaggaaa gattttgttg atttggtttc cccagtagtt agctttcttc cctggattcc tcacttttga agagtgtgag gaaaacctat gtttggcgct taagctttca gctcagctta atgaagtgtt tagcatagta cctctgctat ttgctgttat tttatctgct agtttnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntaatc ttacaaagtg tcttggaatt gtaggtgact attatttttc caagaaatat cccttaagat attaactgag aaggctgggg gtttaatgtg gaaatgatgt ttcaaaagga atcctgtgat ggaaatacaa ctggtatctt cactttttta ggaattggga aatattttaa tgtttcttgg ggaatatgtt agagaattcc cttactcttg attgtgggat atgctattga ttgtttgttt actatttaat tatttcactt tagaaagctg agtgtttcac accttatcta tgtag 411

60 120 180 240 300 360 420 480 540 98677.doc 40- 545 200533758 &lt;210〉 185 &lt;211〉 316 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35153_at HG-U95Av2 &lt;220〉 &lt;221&gt; &lt;222〉 &lt;223〉60 120 180 240 300 360 420 480 540 98677.doc 40- 545 200533758 &lt; 210〉 185 &lt; 211〉 316 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 35153_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; &lt; 222〉 &lt; 223〉

misc一feature (34)..(34) η 為 a，g，c 或 t &lt;400〉 185misc-feature (34) .. (34) η is a, g, c or t &lt; 400> 185

60 120 180 240 300 316 tacattctag atgcaagtct cttgtcggat atangtattg agatattaca cctagtctgt ggcttgactg ttttctttat gtcttttgat gaatagaagt tttaaatttt gacaaggtca aatttatttt tttcttttgt ttgatatttt ttctctccaa tttaacccca agatttcaga tattctgctc tattatataa actttatatt tttatatttg tgatctacct tgaattgata tgtatgttgt gaattatgga tcagggttct ttttttcccc catacaagta tccagtcatt gtaacactgt ttattg &lt;210〉 186 &lt;211〉 38 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 35168_f_at HG-U95Av2 98677.doc -141 - 200533758 &lt;400〉 186 taaatggcca aagcttatag gactctgtga caggttgt &lt;210〉 187 &lt;211〉 539 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35261_at HG-U95Av260 120 180 240 300 316 tacattctag atgcaagtct cttgtcggat atangtattg agatattaca cctagtctgt ggcttgactg ttttctttat gtcttttgat gaatagaagt tttaaatttt gacaaggtca aatttatttt tttcttttgt ttgatatttt ttctctccaa tttaacccca agatttcaga tattctgctc tattatataa actttatatt tttatatttg tgatctacct tgaattgata tgtatgttgt gaattatgga tcagggttct ttttttcccc catacaagta tccagtcatt gtaacactgt ttattg &lt; 210> 186 &lt; 211> 38 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220 &gt; &lt; 223 &gt; Probe 35168_f_at HG-U95Av2 98677.doc -141-200533758 &lt; 400〉 186 taaatggcca aagcttatag gactctgtga caggttgt &lt; 210〉 187 &lt; 211> 539 &lt; 212 〉 DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 35261_at HG-U95Av2

&lt;220〉 &lt;221〉 misc一feature &lt;222〉 46·.76, 325, 327, 328, 349, 372·.406, 499..513 &lt;223〉n 為 a，g，c 或 t&lt; 220〉 &lt; 221〉 misc-feature &lt; 222〉 46 · .76, 325, 327, 328, 349, 372 · .406, 499..513 &lt; 223> n is a, g, c or t

&lt;400〉 187 cgcctagaag nnnnnnnnnn tccgaaaaga tggtgctgga agagacagcc cctacccttt atgtatgcag atccgcacca tgatctctgg acagcggaac nnnnnncgag gacagacaat ggaagaattt caggttcgtg gtgtttcatc gnnnnnnnnn ctgatgacct gctggggann taagaaaaga gtagacccag gcagccatca cagaacattt gtttacagct ttctncnncc nnnnnnnnnn cactgaggcc nnnnnnnnnn agaggcctgt agctaacaga taatgaaggt ccccagagga acaagtacgt ctgtgggctg nnnnnnnnnn tggctccaag nnnctgagtc ggacannnnn aaagctgagg ggacaaagac gctcaaaatg gcatgacgat caagccggna nnnnnncaaa aaaagttgtc ctcaaggtga nnnnnnnnnn aaattccgct cggcagatgg gagttgccgg ggccgagtgt acaacagatg ggtgttcgaa tttctttcgt ctggggact 98677.doc -142- 200533758 &lt;210〉 188 &lt;211&gt; 578 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 35280—at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature &lt;222&gt; 146..275, 295..299, 303 &lt;223&gt; n 為 a，g，c 或 t&Lt; 400> 187 cgcctagaag nnnnnnnnnn tccgaaaaga tggtgctgga agagacagcc cctacccttt atgtatgcag atccgcacca tgatctctgg acagcggaac nnnnnncgag gacagacaat ggaagaattt caggttcgtg gtgtttcatc gnnnnnnnnn ctgatgacct gctggggann taagaaaaga gtagacccag gcagccatca cagaacattt gtttacagct ttctncnncc nnnnnnnnnn cactgaggcc nnnnnnnnnn agaggcctgt agctaacaga taatgaaggt ccccagagga acaagtacgt ctgtgggctg nnnnnnnnnn tggctccaag nnnctgagtc ggacannnnn aaagctgagg ggacaaagac gctcaaaatg gcatgacgat caagccggna nnnnnncaaa aaaagttgtc ctcaaggtga nnnnnnnnnn aaattccgct cggcagatgg gagttgccgg ggccgagtgt acaacagatg ggtgttcgaa tttctttcgt ctggggact 98677.doc -142- 200533758 &lt; 210〉 188 &lt; 211 &gt; 578 &lt; 212〉 DNA &lt; 213> at &gt; 220 &lt; 220 &gt; 220 U95Av2 &lt; 220〉 &lt; 221〉 misc-feature &lt; 222 &gt; 146..275, 295..299, 303 &lt; 223 &gt; n is a, g, c or t

&lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (431)..(500) &lt;223〉n 為 a，g，c 或 t &lt;400〉 188 gatgcgcatc aatgtatttt atcttatttt ctcaatctcc tctctctttc ctccacccat aataagagaa tgttcctact cacacttcag ctgggtcaca tccatccctc cattcatcct tccatccatc tttccatcca ttaccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntaaat ttaaacttac aaacnnnnnt tgncacaagt ggtgtttatt gcaataaccg cttggtttgc aacctctttg ctcaacagaa catatgttgc aagaccctcc catgggggca cttgagtttt ggcaaggctg acagagctct gggttgtgca nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn taacaccagt gggaattgct ggaggaacca gaggcacttc 60 120 180 240 300 360 420 480 98677.doc -143 - 540 200533758 578 caccttggct gggaagacta tggtgctgcc ttgcttct &lt;210〉 189 &lt;211〉 139 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35281 at HG-U95Av2&lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; (431) .. (500) &lt; 223〉 n is a, g, c or t &lt; 400> 188 gatgcgcatc aatgtatttt atcttatttt ctcaatctcc tctctcttttt ctccacccat aatacagc tgtt tgtt cattcatcct tccatccatc tttccatcca ttaccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntaaat ttaaacttac aaacnnnnnt tgncacaagt ggtgtttatt gcaataaccg cttggtttgc aacctctttg ctcaacagaa catatgttgc aagaccctcc catgggggca cttgagtttt ggcaaggctg acagagctct gggttgtgca nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn taacaccagt gggaattgct ggaggaacca gaggcacttc 60 120 180 240 300 360 420 480 98677.doc -143-540 200533758 578 caccttggct gggaagacta tggtgctgcc ttgcttct &lt; 210〉 189 &lt; 211〉 139 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 35281 at HG-U95Av2

&lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （39)..(76) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 189 60 120 139 ataagcaact tcacagaaca cgagacagct tgggaatcnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngaca gttttaagca gaggaataac atcaccactg tatatttcag aaagatcact agggcagcc &lt;210&gt; 190 &lt;211&gt; 340 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223&gt; Probe 35320_at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature &lt;222〉 203, 204, 207..219, 224..228, 231， 233, 234 &lt;223&gt; n 為 a，g，c 或 t 98677.doc • 144 - 200533758 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 238, 240, 241， 243, 245..248 &lt;223&gt; η 為 a，g，c 或 t &lt;400&gt; 190 60 120 180 240 300 340&lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (39) .. (76) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 189 60 120 139 ataagcaact tcacagaaca cgagacagct tgggaatcnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn gttttaagca gaggaataac atcaccactg tatatttcag aaagatcact agggcagcc &lt; 210 &gt; 190 &lt; 211 &gt; 340 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 35320_at HG-U95Av2 &lt; 220> &lt; 222〉 203, 204, 207..219, 224..228, 231, 233, 234 &lt; 223 &gt; n is a, g, c or t 98677.doc • 144-200533758 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 238, 240, 241, 243, 245..248 &lt; 223 &gt; η is a, g, c or t &lt; 400 &gt; 190 60 120 180 240 300 340

gttcttgttc ttcttaaatg tgacatgaaa taattgtgct gctacattat actggaaatt aacaggggaa aagggaagag ctcttggctc ccttgaggtt ctgctagtgg tgttaggagt ggttacaact gagcttttag taaccattta accgtatgta aacttggttt ctaattaaaa aaaaatttct ttttccaaaa aannaannnn nnnnnnnnnt taannnnnaa ntnntttntn nanannnnta caacaacttt gatacaaaaa tactgaaaca gcaactacca cctggaatgg cacactaagt ccacactgtt aggattttct ccttagaaag &lt;210〉 191 &lt;211〉 517 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 35350—at HG-U95Av2 &lt;220&gt; &lt;221&gt; miscjeature &lt;222〉 （305)..(308) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 191 taatgaggct cctccgctct ggacacaacc cttttataga ttaatttctc tgccaattaa 60 9867'doc -145 - 200533758gttcttgttc ttcttaaatg tgacatgaaa taattgtgct gctacattat actggaaatt aacaggggaa aagggaagag ctcttggctc ccttgaggtt ctgctagtgg tgttaggagt ggttacaact gagcttttag taaccattta accgtatgta aacttggttt ctaattaaaa aaaaatttct ttttccaaaa aannaannnn nnnnnnnnnt taannnnnaa ntnntttntn nanannnnta caacaacttt gatacaaaaa tactgaaaca gcaactacca cctggaatgg cacactaagt ccacactgtt aggattttct ccttagaaag &lt; 210> 191 &lt; 211> 517 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223> Probe 35350-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; miscjeature &lt; 222> (305) .. (308) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 191 taatgaggct cctccgctct ggacacaacc cttttataga ttaatttctc tgccaattaa 60 9867'doc -145-200533758

cttgtcattt tcagtacata ttttactatt ccacaccaac cataattaca acaagggatt tttcttatgc actcctatgc atgtgaataa catgtggtgt aattctgctt cttacagaag tattactgaa ggtattattt ccaatattat ttggtttatt atgcggatct tttttatata tgcagtccca tcccttctgt gccactcaat gccatccaga catggttttt ccctccaggg gcctnnnntc tccagagggc acttcggctg cctctgcttc ctctcattcg aggcccggct cttgctgaca gaataggttc cgttctgggc ggtggttctc gagcctgcca ttcaaaacca aagcaaattg gagcatttct cacaacatgg tattgaagtt cctttttgtt ctcaaaagtt gtgaccgtgt taaattgtac tcccttagtc ctgtaag &lt;210〉 192 &lt;211&gt; 518 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 35366—at HG-U95Av2 &lt;221&gt; misc_feature &lt;222〉 122， 136， 144， 155， 168， 180， 186, 204, 213 &lt;223&gt; n 為 a，g，c 或 t &lt;4〇0&gt; 192 aatggtacat tttgccaaag accacttata cttgagaaca tggaagaatt tgcctgatac tctctttggg gaaaagagtc tctcctcttt tcctcaaacc ccagtacact cagcctctct gnccccacct tctccntgac tttngtcctc acttngcttc tgcagtanca ttggaacctn 98677.doc -146- 200533758 gaattngaaa gaaagtcttc cttngaataa ttnggagttt gtcttgagag gcaaatatag ccccaagaat cacaagattc gaggaccatg taggtctttt acgtagccca aatccataaa ttagtctcac tttttgtatt tatcgtttca tattaaaccc tctatatcaa atgttcatca tgattttgta tgatttttat aactatttta ttcattttat tagatttatt ctaaaatttt ttaatggtaa attcttaaac tgtggaaacc actgaaggtg cttattaact gttctcccag atttgtacaa gtattggatg attccttgag tttacagccttgtcattt tcagtacata ttttactatt ccacaccaac cataattaca acaagggatt tttcttatgc actcctatgc atgtgaataa catgtggtgt aattctgctt cttacagaag tattactgaa ggtattattt ccaatattat ttggtttatt atgcggatct tttttatata tgcagtccca tcccttctgt gccactcaat gccatccaga catggttttt ccctccaggg gcctnnnntc tccagagggc acttcggctg cctctgcttc ctctcattcg aggcccggct cttgctgaca gaataggttc cgttctgggc ggtggttctc gagcctgcca ttcaaaacca aagcaaattg gagcatttct cacaacatgg tattgaagtt cctttttgtt ctcaaaagtt gtgaccgtgt taaattgtac tcccttagtc ctgtaag &lt; 210> 192 &lt; 211 &gt; 518 &lt; 212〉 DNA &lt; 213> human &lt; 220> &lt; 223 &gt; Probe 35366-at HG-U95Av2 &lt; 221 &gt; misc_feature &lt; 222> 122, 136, 144, 155, 168, 180, 186, 204, 213 &lt; 223 &gt; n is a, g, c or t &lt; 4〇0 &gt; 192 aatggtacat tttgccaaag accacttata cttgagaaca tggaagaatt tgcctgatac tctctttggg gacaagacngtgt tccctt tcccctcttcttcttctcttcaaccgccttctcctccttctcctt -200533758 gaattngaaa gaaag tcttc cttngaataa ttnggagttt gtcttgagag gcaaatatag ccccaagaat cacaagattc gaggaccatg taggtctttt acgtagccca aatccataaa ttagtctcac tttttgtatt tatcgtttca tattaaaccc tctatatcaa atgttcatca tgattttgta tgatttttat aactatttta ttcattttat tagatttatt ctaaaatttt ttaatggtaa attcttaaac tgtggaaacc actgaaggtg cttattaact gttctcccag atttgtacaa gtattggatg attccttgag tttacagc

&lt;210〉 193 &lt;211&gt; 426 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35367—at HG-U95Av2 &lt;220&gt; &lt;221〉mi sc一feature &lt;222〉 84， 131， 134， 148， 197, 205..297 &lt;223&gt; n 為 a，g，c 或 t&lt; 210> 193 &lt; 211 &gt; 426 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 35367-at HG-U95Av2 &lt; 220 &gt; &lt; 221> mi sc-feature &lt; 222 〉 84, 131, 134, 148, 197, 205..297 &lt; 223 &gt; n is a, g, c or t

&lt;400〉 193 acaattctgg gcacggtgaa gcccaatgca aacagaattg ctttagattt ccaaagaggg aatgatgttg ccttccactt taancccacg cttcaatgag aacaacagga gagtcattgt ttgcaataca naangctgga taataacntg gggaagggaa gaaagacagt cggttttccc att tgaaagt gggaaancca ttcannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngaa 98677.doc -147- 360 200533758 atcagcaaac tgggaatttc tggtgacata gacctcacca gtgcttcata taccatgata taatctgaaa ggggcagatt aaaaaaaaaa aaagaatcta aaccttacat gtgtaaaggt ttcatg &lt;210〉 194 &lt;211&gt; 386 &lt;212&gt; DNA &lt;213&gt;人類&Lt; 400> 193 acaattctgg gcacggtgaa gcccaatgca aacagaattg ctttagattt ccaaagaggg aatgatgttg ccttccactt taancccacg cttcaatgag aacaacagga gagtcattgt ttgcaataca naangctgga taataacntg gggaagggaa gaaagacagt cggttttccc att tgaaagt gggaaancca ttcannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngaa 98677.doc -147- 360 200533758 atcagcaaac tgggaatttc tggtgacata gacctcacca gtgcttcata taccatgata taatctgaaa ggggcagatt aaaaaaaaaa aaagaatcta aaccttacat gtgtaaaggt ttcatg &lt; 210> 194 &lt; 211 &gt; 386 &lt; 212 &gt; DNA &lt; 213 &gt; human

420 426 &lt;220〉 &lt;223&gt; Probe 35372_r^at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （71)..(71) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （182)..(182) &lt;223&gt; n 為 a，g，c 或 t420 426 &lt; 220> &lt; 223 &gt; Probe 35372_r ^ at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (71) .. (71) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222> (182) .. (182) &lt; 223 &gt; n is a, g, c or t

&lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （271)..(285) &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 194 60 tatttgtgca agaatttgga aaaatagaag atgaatcatt gattgaatag ttataaagat gttatagtaa ntttatttta ttttagatat taaatgatgt tttattagat aaatttcaat 98677.doc -148- 120 200533758 cagggttttt agattaaaca aacaaacaat tgggtaccca gttaaatttt catttcagat anacaacaaa taatttttta gtataagtac attattgttt atctgaaatt ttaattgaac taacaatcct agtttgatac tcccagtctt nnnnnnnnnn nnnnngttgg tagtgctgtg ttgaattacg gaataatgag ttagaactat taaaacagcc aaaactccac agtcaatatt agtaatttct tgctggttga aacttg&lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 (271) .. (285) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 194 60 tatttgtgca agaatttgga aaaatagaag atgaatcatt gattgaatag ttataaagat gttatagta ant ttttagatat taaatgatgt aaatttcaat 98677.doc -148- 120 200533758 cagggttttt agattaaaca aacaaacaat tgggtaccca gttaaatttt catttcagat anacaacaaa taatttttta gtataagtac attattgttt atctgaaatt ttaattgaac taacaatcct agtttgatac tcccagtctt nnnnnnnnnn nnnnngttgg tagtgctgtg ttgaattacg gaataatgag ttagaactat taaaacagcc aaaactccac agtcaatatt agtaatttct tgctggttga aacttg tttattagat

&lt;210&gt; 195 &lt;211&gt; 396 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223〉 Probe 35396—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 75..80, 85..87, 90, 178, 180 &lt;223〉n 為 a，g，c 或 t&lt; 210 &gt; 195 &lt; 211 &gt; 396 &lt; 212〉 DNA &lt; 213〉 human &lt; 220〉 &lt; 223〉 Probe 35396-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; 75..80, 85..87, 90, 178, 180 &lt; 223〉 n is a, g, c or t

&lt;400〉 195 aaatcctgcc tttctctctc tttcaatatt ctttggaagt ggccaaaggt aagaaaacag caaaatgtga tctannnnnn ttaacttttt aaaaatacac agtgcaattt taggcatcca agcttggttg aaaannnaan gtttttattt actttcgtgt tttcattaag gcactggaca actgatgttc agtttatttc cttttagaaa gtacctaaaa atttaaaaaa aaacatgggt atgatagaaa tgtgaaagaa aggccaatat aaaaaatcgt aagggaatga atcaaagatg gaataaaatg gtatttaaac acctatcncn tgaaaatcaa tagtctttga aataatcttt 98677.doc -149- 200533758 ggagattctg gcagtgtttt cccagaacaa gtcaag 396 &lt;210〉 196 &lt;211&gt; 461 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35410_at HG-U95Av2 &lt;220&gt;ggagattctg gcagtgtttt 400> 195 aaatcctgcc tttctctctc tttcaatatt ctttggaagt ggccaaaggt aagaaaacag caaaatgtga tctannnnnn ttaacttttt aaaaatacac agtgcaattt taggcatcca agcttggttg aaaannnaan gtttttattt actttcgtgt tttcattaag gcactggaca actgatgttc agtttatttc cttttagaaa gtacctaaaa atttaaaaaa aaacatgggt atgatagaaa tgtgaaagaa aggccaatat aaaaaatcgt aagggaatga atcaaagatg gaataaaatg gtatttaaac acctatcncn tgaaaatcaa tagtctttga aataatcttt 98677.doc -149- 200533758; & lt cccagaacaa gtcaag 396 &lt; 210〉 196 &lt; 211 &gt; 461 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 35410_at HG-U95Av2 &lt; 220 &gt;

&lt;221&gt; &lt;222〉 &lt;223&gt; misc_feature (141)..(157) n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （233)..(249) &lt;223〉n 為 a，g，c 或 t &lt;400〉 196 ccctaggatg ctatttaagt tgtactgtat tagaacactg ggtgtgtcat accgttatct&lt; 221 &gt; &lt; 222〉 &lt; 223 &gt; misc_feature (141) .. (157) n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222> (233) .. (249) ) &lt; 223〉 n is a, g, c or t &lt; 400〉 196 ccctaggatg ctatttaagt tgtactgtat tagaacactg ggtgtgtcat accgttatct

gtgcagaata tatttcctta ttcagaattt ctaaaaattt aagttctgta agggctaata tattctcttc ctatggtttt nnnnnnnnnn nnnnnnntta gtatggcata atgtcatgat ttactcatta aactttgatt ttgtatgcta ttttttcact ataggatgac tannnnnnnn nnnnnnnnnt atacacttta gatagatgaa gaagcccaaa aacagataaa ttcctgattg ctaatttaca tagaaatgta ttctcttggt tttttaaata aaagcaaaat taacaatgat ctgtgctctg aaagttttga aaatatattt gaacaatttg aatataaatt catcatttag 60 120 180 240 300 360 98677.doc -150- 420 200533758 461 tcctcaaaat atatacagca ttgctaagat tttcagatat c &lt;210&gt; 197 &lt;211〉 587 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 35414—s—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature ® &lt;222&gt; 74, 90..94, 99..131, 146..148, 151, 153, 156 &lt;223&gt; n 為 a, g，c 或 t &lt;220〉 &lt;221〉 misc_feature &lt;222&gt; 158, 453..467, 474..489 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 197gtgcagaata tatttcctta ttcagaattt ctaaaaattt aagttctgta agggctaata tattctcttc ctatggtttt nnnnnnnnnn nnnnnnntta gtatggcata atgtcatgat ttactcatta aactttgatt ttgtatgcta ttttttcact ataggatgac tannnnnnnn nnnnnnnnnt atacacttta gatagatgaa gaagcccaaa aacagataaa ttcctgattg ctaatttaca tagaaatgta ttctcttggt tttttaaata aaagcaaaat taacaatgat ctgtgctctg aaagttttga aaatatattt gaacaatttg aatataaatt catcatttag 60 120 180 240 300 360 98677.doc -150- 420 200533758 461 tcctcaaaat atatacagca ttgctaagat tttcagatat c &lt; 210 &gt; 197 &lt; 211〉 587 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 35414-s-at HG-U95Av2 &lt; 220 &gt; &lt;221; misc_feature ® &lt; 222 &gt; 74, 90..94, 99..131, 146..148, 151, 153, 156 &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221〉 misc_feature &lt; 222 &gt; 158, 453..467, 474..489 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 197

60 120 180 240 300 360 420 gccttctact ggtgcctgcg gaagcggcgg aagccgggca gccacacaca ctcagcctct gaggacaaca ccancaacaa cgtgcgggan nnnntgaann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ncaacacggt ccccannnag nantangnga acaagttgag ctatgactta acatagccaa aatgtgagtg gttgaatatg attaaaaata tcaaattaat tgtgtgaact tggaagcaca ccaatcttac tttgtaaatt ctgatttctt ttcaccattc gtacataata ctgaaccact tgtagatttg attttttttt ttaatctact gcatttaggg agtattctaa taagctagtt gaatacttga accataaaat gtccagtaag atcactgttt agatttgcca tagagtacac tgcctgcctt aagtgaggaa atnnnnnnnn nnnnnnnaag ttcnnnnnnn 986~7.doc -151 - 480 540 200533758 nnnnnnnnna taaaacagag taatcttgtt ggttcaccat tgagaccgtg aagatacttt gtattgtcct attagtgtta tatgaacata caaatgcatc tttgatg &lt;210〉 198 &lt;211&gt; 520 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35628_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 29, 44, 53, 62, 75, 226, 308..333, 417 &lt;223〉n 為 a，g，c 或 t &lt;400〉 198 gcctctgtca tctgcctcat caatgctant ggttactaca tctnccgtgg ggncgaattc cnagaaaaac acttnccgaa agaatccttc tgaccccaga gtggctgggc ttgagaccat ctctacagcc acagggcgga aactgctggt gtctgggtgg tggggtatgg tccgccatcc caactatctt ggagacctca tcatggctct ggcttggtcc ttgccntgcg gggtgtcaca cctgctgccc tacttctacc tcctctactt caccgcgctg ctggtgcacc gtgaggcccg ggatgagnnn nnnnnnnnnn nnnnnnnnnn nnnggcctgg caggagtact gccggcgtgt gccttaccgc atcatgccct acatctactg aagcggctcc accaccccag gtggggncat gtgcccactc atccaccagc acacccagga ccaggagcct cgacacactt gggactcaag ggcttgcacc ccacccagcc ctgaggatga acaacctcag 58760 120 180 240 300 360 420 gccttctact ggtgcctgcg gaagcggcgg aagccgggca gccacacaca ctcagcctct gaggacaaca ccancaacaa cgtgcgggan nnnntgaann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ncaacacggt ccccannnag nantangnga acaagttgag ctatgactta acatagccaa aatgtgagtg gttgaatatg attaaaaata tcaaattaat tgtgtgaact tggaagcaca ccaatcttac tttgtaaatt ctgatttctt ttcaccattc gtacataata ctgaaccact tgtagatttg attttttttt ttaatctact gcatttaggg agtattctaa taagctagtt gaatacttga accataaaat gtccagtaag atcactgttt agatttgcca tagagtacac tgcctgcctt aagtgaggaa atnnnnnnnn nnnnnnnaag ttcnnnnnnn 986 ~ 7.doc -151-480 540 200533758 nnnnnnnnna taaaacagag taatcttgtt ggttcaccat tgagaccgtg &&;> &&;; &gt; 210 &210; &lt; 520 &lt; ct &lt; tcgat &lt; ctgat &lt; gat tatga 〉 &Lt; 223 &gt; Probe 35628_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 29, 44, 53, 62, 75, 226, 308..333, 417 &lt; 223〉 n is a, g , C or t &lt; 400〉 198 gcctctgtca tctgcctcat caatgctant ggttactaca tct nccgtgg ggncgaattc cnagaaaaac acttnccgaa agaatccttc tgaccccaga gtggctgggc ttgagaccat ctctacagcc acagggcgga aactgctggt gtctgggtgg tggggtatgg tccgccatcc caactatctt ggagacctca tcatggctct ggcttggtcc ttgccntgcg gggtgtcaca cctgctgccc tacttctacc tcctctactt caccgcgctg ctggtgcacc gtgaggcccg ggatgagnnn nnnnnnnnnn nnnnnnnnnn nnnggcctgg caggagtact gccggcgtgt gccttaccgc atcatgccct acatctactg aagcggctcc accaccccag gtggggncat gtgcccactc atccaccagc acacccagga ccaggagcct cgacacactt gggactcaag ggcttgcacc ccacccagcc ctgaggatga acaacctcag 587

60 120 180 240 300 360 420 480 98677.doc -152- 520 200533758 &lt;210〉 199 &lt;211&gt; 304 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35638—at HG-U95Av260 120 180 240 300 360 420 480 98677.doc -152- 520 200533758 &lt; 210〉 199 &lt; 211 &gt; 304 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 35638--at HG- U95Av2

&lt;400〉 199 tcacttttgc ttgaaaaaaa accccaccct ctgtcctgtg tgcattgtag ctgt aagttccaca taattttaaa gtttggattt aggtttccca tttaaccata gagtaagaca aatggtggct ttaattaaaa atggtgtttt tgcccacatt ttgggtctat tcagctccag actagtagtt tcttgtaaat tagtctcttt tccagctcat cccctttcca ctcttggtgt gtgttggaca attcctagtt tcattttata aaatttttca taaaacactt aatgtgaaga ggtgagaaac 60 120 180 240 300 304 &lt;210&gt; 200 • &lt;211&gt; 500 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 35664—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 55..75, 79, 84..87, 93, 113..116, 129..131, 147, 273 &lt;223&gt; n 為 a，g，c 或 t 98677.doc -153 - 60 60&Lt; 400> 199 tcacttttgc ttgaaaaaaa accccaccct ctgtcctgtg tgcattgtag ctgt aagttccaca taattttaaa gtttggattt aggtttccca tttaaccata gagtaagaca aatggtggct ttaattaaaa atggtgtttt tgcccacatt ttgggtctat tcagctccag actagtagtt tcttgtaaat tagtctcttt tccagctcat cccctttcca ctcttggtgt gtgttggaca attcctagtt tcattttata aaatttttca taaaacactt aatgtgaaga ggtgagaaac 60 120 180 240 300 304 &lt; 210 &gt; 200 • &lt; 211 &gt; 500 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 35664-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 55..75, 79, 84. .87, 93, 113..116, 129..131, 147, 273 &lt; 223 &gt; n is a, g, c or t 98677.doc -153-60 60

200533758 &lt;400&gt; 200 gtacactcaa gtctaagaat atatgagtgg atcatttacc gccccccgcc ccacnnnnnn nnnnnnnnnn nnnnngtcnt tttnnnnaat aangtattct tctatggtag tannnnccta cagatctgnn ncccttcttc ttctaanggg taagtcataa tctgtgtaat actacaattt atgggatgct cactatgccc tgtttctctt ctaaacaatt tacatgtaat gtctcattcc tcacaataac ccttgtaaag tgggcatgat tanccatgat ttttatagtt gaagaaccta agacacagag accaaggccc atgagctcat agggctgagg caggatttgg aatcaggcca tgtcttctcc agagcccaca tccatccttt ctctatattg cctcccacag atgtgctaaa atttatttaa ctaatccttt atcctctatt tgtgttgtct cccatttttt attattacaa tattactgtg gtgaacatgc &lt;210&gt; 201 &lt;211&gt; 494 &lt;212〉 DNA &lt;213&gt;人類 • &lt;220〉 &lt;223〉Probe 35666HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 33, 35, 45..54, 168, 203..257, 304, 306, 348..362, 427 &lt;223〉n 為 a，g, c 或 t &lt;400〉 201 gaagaagggg ccatcacagg atgccacccc tgncntgggt tgggnnnnnn nnnncacgac cagccccttc ctgggtattt attctctatt tattggggat aggagaagag gcatcctgcc 98677.doc 120 180 240 300 360 420 480 500 60 -154- 120 200533758200533758 &lt; 400 &gt; 200 gtacactcaa gtctaagaat atatgagtgg atcatttacc gccccccgcc ccacnnnnnn nnnnnnnnnn nnnnngtcnt tttnnnnaat aangtattct tctatggtag tannnnccta cagatctgnn ncccttcttc ttctaanggg taagtcataa tctgtgtaat actacaattt atgggatgct cactatgccc tgtttctctt ctaaacaatt tacatgtaat gtctcattcc tcacaataac ccttgtaaag tgggcatgat tanccatgat gaagaaccta agacacagag accaaggccc atgagctcat agggctgagg caggatttgg aatcaggcca tgtcttctcc agagcccaca tccatccttt ctctatattg cctcccacag atgtgctaaa atttatttaa ctaatccttt ttttatagtt atcctctatt tgtgttgtct cccatttttt attattacaa tattactgtg gtgaacatgc &lt; 210 &gt; 201 &lt; 211 &gt; 494 &lt; 212〉 DNA &lt; 213 &gt; Human • &lt; 220〉 &lt; 223〉 Probe 35666HG-U95Av2 &lt; 220 &gt; &lt;221; &lt; 221 222 &gt; 33, 35, 45..54, 168, 203..257, 304, 306, 348..362, 427 &lt; 223〉 n is a, g, c or t &lt; 400〉 201 gaagaagggg ccatcacagg atgccacccc tgncntgggt tgggnnnnnn nnnncacgac cagccccttc ctgggtattt attctctatt tattggggat aggagaagag gcatcctgcc 98677.doc 120 180 240 300 360 4 20 480 500 60 -154- 120 200533758

tgggtgggac agccccttca gccccttctc ccctccccgc ctggccangg cagggccacc 180 ccactctacc tccttagctt tcnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240 nnnnnnnnnn nnnnnnnaga gctgacggga ggccccagct ctgaggggag ggggtccgtg 300 gtanangcct ggggccggta gaggctcccc agggctccct tatgtccnnn nnnnnnnnnn 360 nngggtgtgg atgtaattag ctctgggggg cagttgggta gatgggtggg ggctcctggt 420 ggccttntgc tgcccaggcc acagccgcct ttgggttcca tcttgctaat aaacactggc 480 tctgggacta gaaa 494 &lt;210&gt; 202 &lt;211&gt; 385 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 35702—at HG-U95Av2 &lt;400〉 202 aggaatgtgc cctggagatc atcaaagggg gagctctgcg ccaagaagaa gtgtattatg 60 acagctcact ctggaccact cttctgatca gaaatccatg caggaagatc ctggaatttc 120 tctactcaac gagctataat atggacagat tcataaacaa gtaggaactc cctgagggct 180 gggcatgctg agggattttg ggactgttct gtctcatgtt tatctgagct cttatctatg 240 aagacatctt cccagagtgt ccccagagac atgcaagtca tgggtcacac ctgacaaatg 300 gaaggagttc ctctaacatt tgcaaaatgg aaatgtaata ataatgaatg tcatgcaccg 360 ctgcagccag cagttgtaaa attgt 385 98677.doc ，155， 200533758 &lt;210〉 203 &lt;211&gt; 534 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 357201 HG-U95Av2 &lt;220&gt;tgggtgggac agccccttca gccccttctc ccctccccgc ctggccangg cagggccacc 180 ccactctacc tccttagctt tcnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240 nnnnnnnnnn nnnnnnnaga gctgacggga ggccccagct ctgaggggag ggggtccgtg 300 gtanangcct ggggccggta gaggctcccc agggctccct tatgtccnnn nnnnnnnnnn 360 nngggtgtgg atgtaattag ctctgggggg cagttgggta gatgggtggg ggctcctggt 420 ggccttntgc tgcccaggcc acagccgcct ttgggttcca tcttgctaat aaacactggc 480 tctgggacta gaaa 494 &lt; 210 &gt; 202 &lt; 211 &gt; 385 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 35702-at HG-U95Av2 &lt; 400> 202 aggaatgtgc cctggagatc atcaaagggg gagctctgcga ccagtatgat acagctatcgat ctctctcgat ctctcgat ctact gagctataat atggacagat tcataaacaa gtaggaactc cctgagggct 180 gggcatgctg agggattttg ggactgttct gtctcatgtt tatctgagct cttatctatg 240 aagacatctt cccagagtgt ccgagat gggta taga ctga ctga agcaagtca tgggtcacaccgg ctga ctga cagttgtaaa attgt 385 98677.doc, 155, 200533758 &lt; 210> 203 &lt; 211 &gt; 534 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 357201 HG-U95Av2 &lt; 220 &gt;

&lt;221&gt; misc_feature &lt;222〉 （79)..(79) &lt;223&gt; η 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc.feature &lt;222〉 （164)..(164) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; (405)·.(438) • &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 203 60 120 180 240 acttcaaatt ggacccagga gccaaacatt cccaacctat ccctaaaggg tggacaagct tcatttacac gatatctgna gatgtgtata ttgggcccga tgatgcacaa caaaaaatag aacctcatca cacagcagtg cttggagaag gtgacagtgt ccangtggag aacaaggatc ccaagagaag ccactttgtc ttaattgctg gggagccatt aagagaacca gttatccaac atggtccatt tgtgatgaac accaatgaag agatttctca agctattctt gatttcagaa 300 98677.doc -156- 200533758 acgcaaaaaa tgggtttgaa agggccaaaa cctggaaatc aaagattggg aactagtgga aagcggaaga gcaggtcttg atgtgtccta gaattttgcc atttnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnaa get tatttag ccggtgcttc taaagaattc cacactaacg tgataacatg gtttttgtaa caataaatgt aggatatttc ctggcacatg caaa&lt; 221 &gt; misc_feature &lt; 222> (79) .. (79) &lt; 223 &gt; η is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc.feature &lt; 222> (164) .. (164) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; (405) ·. (438) • &lt; 223 &gt; n is a, g, c or t &lt; 400> 203 60 120 180 240 acttcaaatt ggacccagga gccaaacatt cccaacctat ccctaaaggg tggacaagct tcatttacac gatatctgna gatgtgtata ttgggcccga tgatgcacaa caaaaaatag aacctcatca cacagcagtg cttggagaag gtgacagtgt ccangtggag aacaaggatc ccaagagaag ccactttgtc ttaattgctg gggagccatt aagagaacca gttatccaac atggtccatt tgtgatgaac accaatgaag agatttctca agctattctt gatttcagaa 300 98677.doc -156- 200533758 acgcaaaaaa tgggtttgaa agggccaaaa cctggaaatc aaagattggg aactagtgga aagcggaaga gcaggtcttg atgtgtccta gaattttgcc atttnnnnnn nnnnnnnnnn nnnnnnnnnnnn nnnnnnnnaa get tatttag ccggtgcttc taaagaattc cacacta acag agg agt

&lt;210〉 204 &lt;211〉 553 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 35735—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 37, 74, 86, 199..214, 490 &lt;223〉n 為 a，g，c 或 t &lt;400〉 204 acacggtcta gatttcaagc aggaaggtgg gaagaaaact accattagac ttatagcaac ataattcaat tgagcaataa taangcaaac aagaaaccat tetettatnn aattgacact gtataatttg taettattat tgtgatttct cacctnatac gggcaggagt nnnnnnnnnn ggattaaaca caaagatgga ttagaatgtt ggacatngcc agagatetag aggaattgag nnnnattata aattcacata ctttaaaaga aaagcttatg catgtataat aatetettta tgataaacaa acttcaatgg atgccaaata tgctgtgtaa atagtctttt cctcactgat tgttctccag ttgggctaat gacactttag cacaatgtat ctaaactgaa etaattetta 98677.doc -157- 480 200533758 acactcatac ttgaaatctt tctgagtttc cccagaagag aatatgggat tttttttgac atttttgacn catttaataa tgctcttgtg tttacctagt atatgtagac tttgtcttat gtgtcaaaag tcc &lt;210&gt; 205 &lt;211〉 466 &lt;212&gt; DNA &lt;213&gt;人類&lt; 210〉 204 &lt; 211〉 553 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223〉 Probe 35735—at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 37, 74, 86, 199..214, 490 &lt; 223> n is a, g, c or t &lt; 400> 204 acacggtcta gatttcaagc aggaaggtgg gaagaaaact accattagac ttatagcaac ataattcaat tgagcaataa taangcaaac aagaaaccat tetettatnn aattgacact gtataatttg taettattat tgtgatttct cacctnatac gggcaggagt nnnnnnnnnn ggattaaaca caaagatgga ttagaatgtt ggacatngcc agagatetag aggaattgag nnnnattata aattcacata ctttaaaaga aaagcttatg catgtataat aatetettta tgataaacaa acttcaatgg atgccaaata tgctgtgtaa atagtctttt cctcactgat tgttctccag ttgggctaat gacactttag cacaatgtat ctaaactgaa etaattetta 98677.doc -157- 480 200533758 acactcatac ttgaaatctt tctgagtttc cccagaagag aatatgggat tttttttgac atttttgacn catttaataa tgctcttgtg tttacctagt atatgtagac tttgtcttat gtgtcaaaag tcc &lt; 210 &gt; 205 &lt; 211 〉 466 &lt; 212 &gt; DNA &lt; 213 &gt; human

540 553 &lt;220&gt; &lt;223〉 Probe 35766一at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc一feature 、 &lt;222&gt; 26, 166..168, 300..336 &lt;223&gt; n 為 a，g，c 或 t540 553 &lt; 220 &gt; &lt; 223〉 Probe 35766-at HG-U95Av2 &lt; 220> &lt; 221 &gt; mi sc-feature, &lt; 222 &gt; 26, 166..168, 300..336 &lt; 223 &gt; n For a, g, c or t

&lt;400〉 205 tgaggagagc cgctcacaga atctgaaggc atggagcagc gagggacagc nnnnnnnnnn gccttggaca gatggcaaag accacagtgg gctgagacgt cagcttggag tcaacgggat gccaggccca nnnnnnnnnn gcagcaactc tggtgtctga tcaccnacac acagtccagt aacagcctga cctgctgcac ggagtatgag nnnnnnnnnn catgcaaacc gaccaatgac agtctgctga ccttggagat gggaggtgga cttgagtcag gccctgctga nnnnnnggcg atccaaaaga accaaagttc ggttggagct cgacctggac ggcccnnnta agctggcaca acatcaaggt aggactttaa ccaccacccg tgaggc gctgagacga tccatgagaa cgccctacag gacccgggca caagctggan tcttggtgat ccggatagtg 60 120 180 240 300 360 420 466 98677.doc -]58 - 200533758 &lt;210&gt; 206 &lt;211&gt; 559 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35803,at HG-U95Av2 &lt;220〉 &lt;221&gt; &lt;222&gt; &lt;223〉&Lt; 400> 205 tgaggagagc cgctcacaga atctgaaggc atggagcagc gagggacagc nnnnnnnnnn gccttggaca gatggcaaag accacagtgg gctgagacgt cagcttggag tcaacgggat gccaggccca nnnnnnnnnn gcagcaactc tggtgtctga tcaccnacac acagtccagt aacagcctga cctgctgcac ggagtatgag nnnnnnnnnn catgcaaacc gaccaatgac agtctgctga ccttggagat gggaggtgga cttgagtcag gccctgctga nnnnnnggcg atccaaaaga accaaagttc ggttggagct cgacctggac ggcccnnnta agctggcaca acatcaaggt aggactttaa ccaccacccg tgaggc gctgagacga tccatgagaa cgccctacag gacccgggca caagctggan tcttggtgat ccggatagtg 60 120 180 240 300 360 420 466 98677.doc-] 58-200533758 &lt; 210 &gt; 206 &lt; 211 &gt; 559 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 35803, at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; &lt; 222 &gt; &lt; 223>

misc_feature 30, 31, 106..110, 112..117, 119..195 n 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc一feature &lt;222&gt; 201..256, 425..441 &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 206 gtgtcattgc taaaacctca ctgaacagan ngcagccaag gtctgtgttc agcacttggt ctctgttgtt acgtaaaata ataagcattt aaaatagttt acagannnnn tnnnnnngnnmisc_feature 30, 31, 106..110, 112..117, 119..195 n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222 &gt; 201..256, 425. .441 &lt; 223> n is a, g, c or t &lt; 400 &gt; 206 gtgtcattgc taaaacctca ctgaacagan ngcagccaag gtctgtgttc agcacttggt ctctgttgtt acgtaaaata ataagcattt aaaatagttt acagannnnn tnnn

60 120 180 240 300 360 420 cnnttnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt nnnnnnnnnn nnnnnnnnnn nnnnnctttc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntggc aggagagatt aaggtaatta caacactcag ttctatgtct tacaagcact ttgtcttgtc tctgcaagaa aattcgattc cagtcatttc ccataaaata cagacatttt accaacataa tatgctttga ttgatgcagc attatgcttt gggcagtatt acaannnnnn nnnnnnnnnn nttctgtatt taaatattgt aaaaagaaaa taagttataa 98677.doc -159- 480 540 200533758 559 ctgttataaa gcagaacttt tgttgcattt tttaaactgt tgaagtcact gtgtatgttt gtttggtcaa tgtttccgc &lt;210&gt; 207 &lt;211〉 542 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35822_at HG-U95Av2 籲 &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 31， 55, 66, 72, 97, 99, 176, 229, 273, 286 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 298, 308, 323..386, 458, 459 &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 20760 120 180 240 300 360 420 cnnttnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt nnnnnnnnnn nnnnnnnnnn nnnnnctttc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntggc aggagagatt aaggtaatta caacactcag ttctatgtct tacaagcact ttgtcttgtc tctgcaagaa aattcgattc cagtcatttc ccataaaata cagacatttt accaacataa tatgctttga ttgatgcagc attatgcttt gggcagtatt acaannnnnn nnnnnnnnnn nttctgtatt taaatattgt aaaaagaaaa taagttataa 98677.doc -159- 480 540 200533758 559 ctgttataaa gcagaacttt tgttggcattt tttaaactgt tgaagtcact gtgtatgttt gtttggtcaa tgtttccgc &lt; 210 &gt; 207 &lt; 211〉 542 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220> &lt; 223_at &gt; 223 + gt Probe ; 221 &gt; mi sc-feature &lt; 222〉 31, 55, 66, 72, 97, 99, 176, 229, 273, 286 &lt; 223〉 n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; 298, 308, 323..386, 458, 459 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 207

60 120 180 240 300 360 ggccagacta tcaggcccat ttgtctcccc ntgcaccgag ggaacaactc gagcntttga ggcttncctc cnaactacca cttgccagca acaaaangna agagctgctc cctgcacagg atatcaaagc tctgtttgtg tctgaggagg agaaaaagct gactcggaag gaggtnctac atcaagaatg gggataagaa aggcagctgt gagagagatg ctcaatatng ccccaggcta tgacaaagtc aaggacatct cagaggtggt cancccctcg gttccntttg tactggangg agtgagtncc ctatgctgac ccnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnttca agttggtgta atcagctggg gagtagtgga 98677.doc -160 - 420 200533758 tgtctgcaaa aaccagaagc ggcaaaagca ggtacctnnt cacgcccgag actttcacat caacctcttt caagtgctgc cctggctgaa ggagaaactc caagatgagg atttgggttt tc &lt;210&gt; 208 &lt;211&gt; 344 &lt;212〉 DNA &lt;213&gt;人類60 120 180 240 300 360 ggccagacta tcaggcccat ttgtctcccc ntgcaccgag ggaacaactc gagcntttga ggcttncctc cnaactacca cttgccagca acaaaangna agagctgctc cctgcacagg atatcaaagc tctgtttgtg tctgaggagg agaaaaagct gactcggaag gaggtnctac atcaagaatg gggataagaa aggcagctgt gagagagatg ctcaatatng ccccaggcta tgacaaagtc aaggacatct cagaggtggt cancccctcg gttccntttg tactggangg agtgagtncc ctatgctgac ccnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnttca agttggtgta atcagctggg gagtagtgga 98677. doc -160-420 200533758 tgtctgcaaa aaccagaagc ggcaaaagca ggtacctnnt cacgcccgag actttcacat caacctcttt caagtgctgc cctggctgaa ggagaaactc caagatgagg atttgggttt tc &lt; 210 &gt; 208 &lt; 211 &gt; DNA 211 &gt; 211 &gt; 211 &gt;

&lt;220〉 &lt;223&gt; Probe 35824—at HG-U95Av2&lt; 220> &lt; 223 &gt; Probe 35824—at HG-U95Av2

&lt;400&gt; 208 tgaaaatggc acagtttatg acggactttc ttagtttcac agtatgtttt gtgtgttggt cttggagcat ttaaaataat ttttggattt attcttcctt attttcctga gaatttttaa tatctttagt ttttattaat tctttttgtg tgttctaaaa gggggaataa actgtgtgct tacttgaaga ttagagaaga gtcattgtga cttagactga cttataatgc aactgcaata gtttctagtt caatcaatgt gtgattgctt catctagctt tgtttagttt aatt tttttaaaat ctgtgagaaa tttccttttc tgacaatcat tgtactattg &lt;210&gt; 209 &lt;211&gt; 537 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35844_at HG-U95Av2 98677.doc -161 -&Lt; 400 &gt; 208 tgaaaatggc acagtttatg acggactttc ttagtttcac agtatgtttt gtgtgttggt cttggagcat ttaaaataat ttttggattt attcttcctt attttcctga gaatttttaa tatctttagt ttttattaat tctttttgtg tgttctaaaa gggggaataa actgtgtgct tacttgaaga ttagagaaga gtcattgtga cttagactga cttataatgc aactgcaata gtttctagtt caatcaatgt gtgattgctt catctagctt tgtttagttt aatt tttttaaaat ctgtgagaaa tttccttttc tgacaatcat tgtactattg &lt; 210 &gt; 209 &lt; 211 &gt; 537 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 35844_at HG-U95Av2 98677.doc -161-

200533758 &lt;220〉 &lt;221&gt; misc—feature &lt;222〉 63..78, 239..241， 263, 264, 267, 268, 270 &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 209 tacagtaacc acatgcggct gtttaaagtt aagccaatta aaatcacata agattaaaaa ttnnnnnnnn nnnnnnnnta accacgtttc tagaggcgtc actgtatgta gttcatggct actgtactga cagcgagagc atgtccatct gttggacagc actattctag agaactaaac tggcttaacg agtcacagcc tcagctgtgc tgggacgacc cttgtctccc tgggtaggnn ngggggggaa tgggggaggg ctnnatnngn ccccagctgg ggcctgttgt ctgggaccct ccctctcctg agaggggagg cctggtggct tagcctgggc aggtcgtgtc tcctcctgac cccagtggct gcggtgaggg gaaccaccct cccttgctgc accagtggcc attagctccc gtcaccactg caacccaggg tcccagctgg ctgggtcctc ttctgccccc agtgcccttc cccttgggct gtgttggagt gagcacctcc tctgtaggca cctctcacac tgttgtc &lt;210〉 210 &lt;211&gt; 338 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 35938_at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature &lt;222&gt; (82)..(82) &lt;223〉n 為 a，g，c 或 t 60 120 180 240 300 360 420 480 537 98677.doc 162- 200533758 &lt;400〉 210 aggcagtttg caatcccatg acaactggat ttaaaagtac agtacagata gtcgtactga tcatgagaga ctggctgata cncaaagttg cagttactta gctgcatgag aataatacta ttataagtta ggttgacaaa tgatgttgat tatgtaagga tatacttagc tacattttca gtcagtatga acttcctgat acaaatgtag ggatatatac tgtattttta aacatttctc accaactttc ttatgtgtgt tctttttaaa aatttttttt cttttaaaat atttaacagt200533758 &lt; 220〉 &lt; 221 &gt; misc—feature &lt; 222〉 63..78, 239..241, 263, 264, 267, 268, 270 &lt; 223> n is a, g, c or t &lt; 400 &gt; 209 tacagtaacc acatgcggct gtttaaagtt aagccaatta aaatcacata agattaaaaa ttnnnnnnnn nnnnnnnnta accacgtttc tagaggcgtc actgtatgta gttcatggct actgtactga cagcgagagc atgtccatct gttggacagc actattctag agaactaaac tggcttaacg agtcacagcc tcagctgtgc tgggacgacc cttgtctccc tgggtaggnn ngggggggaa tgggggaggg ctnnatnngn ccccagctgg ggcctgttgt ctgggaccct ccctctcctg agaggggagg cctggtggct tagcctgggc aggtcgtgtc tcctcctgac cccagtggct gcggtgaggg gaaccaccct cccttgctgc accagtggcc attagctccc gtcaccactg caacccaggg tcccagctgg ctgggtcctc ttctgccccc agtgcccttc cccttgggct gtgttggagt gagcacctcc tctgtaggca cctctcacac tgttgtc &lt; 210〉 210 &lt; 211 &gt; 338 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 35938_at HG-U95Av2 misc feature &lt; 222 &gt; (82) .. (82) &lt; 223〉 n is a, g, c or t 60 120 180 240 300 360 420 480 537 98677.doc 162- 2005 33758 &lt; 400> 210 aggcagtttg caatcccatg acaactggat ttaaaagtac agtacagata gtcgtactga tcatgagaga ctggctgata cncaaagttg cagttactta gctgcatgag aataatacta ttataagtta ggttgacaaa tgatgttgat tatgtaagga tatacttagc tacattttca gtcagtatga acttcctgat acaaatgtag ggatatatac tgtattttta aacatttctc accaactttc ttatgtgtgt tctttttaaa aatttttttt cttttaaaat atttaacagt

tcaatctcaa taagacctcg cattatgtat gaatgtta &lt;210〉 211 &lt;211&gt; 576 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220〉 &lt;223〉Probe 35966HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 335, 337..345, 424..466, 471, 472, 474, 483..486 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 211 ccatttttaa tggcacacca aaaatcctac gataattggt gaagaggtgt tggatgacaa aagtctttgt tctagaattg tccagttctg tgaagaaaat gttggaatat aattcaaaag catctgatac ttggatgaat cttcatttgt tcaaggcatc cgtctccttt caaccattga aatactctga atttaaaata ccctgaagtc caatctaaac tttagtttag atctgatttc 98677.doc -163 - 300 200533758 agacaaatgc tgtgtggaaa catctatcct atagatcatc ctattcttat gtgtctttgg ttatcagatc aattacagaa taattgtgtt gtganannnn nnnnnaaatt gctcattaat ttttatttac agattgaaaa agaggcaccg tgtaaagaaa atggcaaaat aaatatcttt ccannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnggaa nnangtagcc ttnnnnattt tatgattttt tcatatgtgg aaatctatta catgtaatac aaaacaaaca tgtagtttga aggcggtcag atttctttga gaaatc 360 420 480 540 576tcaatctcaa taagacctcg cattatgtat gaatgtta &lt; 210〉 211 &lt; 211 &gt; 576 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 35966HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt;222; 335, 337..345, 424..466, 471, 472, 474, 483..486 &lt; 223 &gt; n is a, g, c or t &lt; 400> 211 ccatttttaa tggcacacca aaaatcctac gataattggt gaagaggtgt tggatgacaa aagtctgttgt tctttagat tgaagaaaat gttggaatat aattcaaaag catctgatac ttggatgaat cttcatttgt tcaaggcatc cgtctccttt caaccattga aatactctga atttaaaata ccctgaagtc caatctaaac tttagtttag atctgatttc 98677.doc -163 - 300 200533758 agacaaatgc tgtgtggaaa catctatcct atagatcatc ctattcttat gtgtctttgg ttatcagatc aattacagaa taattgtgtt gtganannnn nnnnnaaatt gctcattaat ttttatttac agattgaaaa agaggcaccg tgtaaagaaa atggcaaaat aaatatcttt ccannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnggaa nnangtagcc ttnnnnattt tatgattttt tcatatgtgg aaatctatta catgtaatac aaaacaaaca tgtagtttga aggcggtcag atttctttga gaaatc 360 420 480 540 576

&lt;210&gt; 212 &lt;211&gt; 451 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 35992—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 28, 29, 31·.47, 49, 53, 56, 62, 66, 68， 151， 152&lt; 210 &gt; 212 &lt; 211 &gt; 451 &lt; 212〉 DNA &lt; 213〉 Human &lt; 220〉 &lt; 223 &gt; Probe 35992-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222〉 28, 29, 31 ·. 47, 49, 53, 56, 62, 66, 68, 151, 152

&lt;220〉 &lt;221&gt; misc_feature &lt;222〉 154..184, 229, 335, 348, 349, 353, 354 &lt;223&gt; η 為 a，g，c 或 t &lt;400〉 212 60 120 tggagacaca cttcccagat caccgcanng nnnnnnnnnn nnnnnnngnt ctnggncgtt cnggcntncc tgccgggtgg cttcttcaat cccgtctcct tcccaagctc ccggcttttt 98677.doc -164- 200533758 ctaatcaggc nnnntgcgcc ctacctgcag gctccgggcg gagcgcgcag gccccgaggc aggcgtctgt aacctgtgtg cacccccagc ccccaactcc ggtgggcggc tgcactacca caaccctctc gggtcttctt tccgactcca aacaccacgt ttaccatagc caggaaataa nncnnnnnnn cgggcctccc gactctctgc cctgncgcgc aagtgatcct c nnnnnnnnnn tctccgccnc atcaggtctc aggttctnnc gcgataggga nnnnnnnnnn gctcctgctc cccactccac ccnngcggag acgcgccctt ® &lt;210&gt; 213 &lt;211〉 342 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36057_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （91)..(140) &lt;223&gt; n 為 a, g，c 或 t&lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 154..184, 229, 335, 348, 349, 353, 354 &lt; 223 &gt; η is a, g, c or t &lt; 400〉 212 60 120 tggagacaca cttcccagat caccgcanng nnnnnnnnnn nnnnnnngnt ctnggncgtt cnggcntncc tgccgggtgg cttcttcaat cccgtctcct tcccaagctc ccggcttttt 98677.doc -164- 200533758 ctaatcaggc nnnntgcgcc ctacctgcag gctccgggcg gagcgcgcag gccccgaggc aggcgtctgt aacctgtgtg cacccccagc ccccaactcc ggtgggcggc tgcactacca caaccctctc gggtcttctt tccgactcca aacaccacgt ttaccatagc caggaaataa nncnnnnnnn cgggcctccc gactctctgc cctgncgcgc aagtgatcct c nnnnnnnnnn tctccgccnc atcaggtctc aggttctnnc gcgataggga nnnnnnnnnn gctcctgctc cccactccac ccnngcggag acgcgccctt ® &lt; 210 &gt; 213 &lt; 211〉 342 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 36057_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 〉 (91) .. (140) &lt; 223 &gt; n is a, g, c or t

&lt;400&gt; 213 aaattctgat tggttatgta ccgtcaaaag acttgaagaa atttcatgat tttgcagtgt ggaagcgttg aaaattgaaa gttactgctt nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn aatgtatcat ccagagtgat gttatctgtg acagtcacca gctttaagct gaaccatttt atgaatacca aataaataga cctcttgtac tgaaaacata tttgtgactt taatcgtgct gcttggatag aaatattttt actggttctt ctgaattgac 98677.doc -165- 200533758 agtaaacctg tccattatga atggcctact gttctattat tt &lt;210&gt; 214 &lt;211&gt; 520 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 36059_at HG-U95Av2 &lt;220〉 &lt;221&gt; miscjeature &lt;222&gt; 90..107, 115..140, 259..273, 275..277, 388, 390, 404 &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 214 gaaggatctt attgcacttg ggctgttcag aatgtagaaa ggacatattt gaggaagtat ctatttgagc actgatttac tctgtaaaan nnnnnnnnnn nnnnnnntaa actannnnnn nnnnnnnnnn nnnnnnnnnn tgtaatggtt ttaacgttac tcactggaga gattggactt tctggagtta tttaaccact atgttcagta ttttaggact ttatgataat ttaatataaa tttagctttt cttaatcann nnnnnnnnnn nnnannnatg actaatcctg cacctgctct gtctggcaga cccatgctgt ggaaaacctg cttacagaca tcacttttaa gtcctttgtg gatgtgggca cagtgaagag caataaanan tgtgaggttc ctgntggagt tttcagctca tctggagaag acaggtcgaa ggccagagtt ccttgactga tgaaaccttt atttcctctg gaagaaggaa tgggtagatg gggtttcctc tttgagttgc &lt;210&gt; 215 342&Lt; 400 &gt; 213 aaattctgat tggttatgta ccgtcaaaag acttgaagaa atttcatgat tttgcagtgt ggaagcgttg aaaattgaaa gttactgctt nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn aatgtatcat ccagagtgat gttatctgtg acagtcacca gctttaagct gaaccatttt atgaatacca aataaataga cctcttgtac tgaaaacata tttgtgactt taatcgtgct gcttggatag aaatattttt actggttctt ctgaattgac 98677.doc -165- 200533758 agtaaacctg tccattatga atggcctact gttctattat tt &lt; 210 &gt; 214 &lt; 211 &gt; 520 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 36059_at HG-U95Av2 &lt; 220> &lt; 221 &gt; miscjeature &lt; 222 &gt; 90..107, 115. .140, 259..273, 275..277, 388, 390, 404 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 214 gaaggatctt attgcacttg ggctgttcag aatgtagaaa ggacatattt gaggaagtat ctatttgagcnnnnnnnnnnnnn nnnnnnnnn nnnnnnnn tgtaatggtt ttaacgttac tcactggaga gattggactt tctggagtta tttaaccact atgttcagta ttttaggact ttatgataat ttaatataaa tttagctttt cttaatcann nnnnnnnnnn nnnannnatg actaatcctg c acctgctct gtctggcaga cccatgctgt ggaaaacctg cttacagaca tcacttttaa gtcctttgtg gatgtgggca cagtgaagag caataaanan tgtgaggttc ctgntggagt tttcagctgatctgt ccttt ccttgcc ccttgcc

60 120 180 240 300 360 420 480 98677.doc -166- 52060 120 180 240 300 360 420 480 98677.doc -166- 520

200533758 &lt;211〉 466 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36065_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc.feature &lt;222〉 （46)..(46) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 215 ggcccagcaa ggtaatttat ggttgagctg atgtcaattg gttctngtct tgagtcgact caatttagcc caagtgctga aacaagaaat gtcatttttt tcatcaaaga caccagggca gatttttaag taaagaaaga caattggacc cttaagaatt tatgcatttg taaagttgct gttgatccaa atattttcaa gccatgtaat ccattggttt tgtgggcagt ttaataaacc tgaacctttg tgtgttttct aattgtacct gagttgacca tcctttcttt ttatagtata tttcttgtat gatattttgt aaagctctca cctggttctt ttatggggac ttttcgtttt200533758 &lt; 211〉 466 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 36065_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc.feature &lt; 222〉 (46) .. 46) &lt; 223 &gt; n is a, g, c or t &lt; 400> 215 ggcccagcaa ggtaatttat ggttgagctg atgtcaattg gttctngtct tgagtcgact caatttagcc caagtgctga aacaagaaat gtcatttttt tcatcaaaga caccagggca gatttttaag taaagaaaga caattggacc cttaagaatt tatgcatttg taaagttgct gttgatccaa atattttcaa gccatgtaat ccattggttt tgtgggcagt ttaataaacc tgaacctttg tgtgttttct aattgtacct gagttgacca tcctttcttt ttatagtata tttcttgtat gatattttgt aaagctctca cctggttctt ttatggggac ttttcgtttt

tgggcaactc cagtgtattt atgtgaaact ttataagaga attaattttt ccatttgcat attaatatgt tcctccacac atgtaaaggc acagtggctc cgtgtg &lt;210&gt; 216 &lt;211&gt; 342 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36103_at HG-U95Av2 60 120 180 240 300 360 420 466 98677.doc -167- 200533758 &lt;220&gt; &lt;221&gt; misc^feature &lt;222〉 65·.80, 202, 204, 215, 216, 218, 229..253 &lt;223〉η 為 a，g，c 或 t &lt;400〉 216tgggcaactc cagtgtattt atgtgaaact ttataagaga attaattttt ccatttgcat attaatatgt tcctccacac atgtaaaggc acagtggctc cgtgtg &lt; 210 &gt; 216 &lt; 211 &gt; 342 &lt; 212> DNA &lt; 213 &gt; human & lt 120_220; 220 &gt; 220 &gt; 220 &gt; 220 &gt; 220 &gt; 220 &gt; 420 466 98677.doc -167- 200533758 &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222〉 65 · .80, 202, 204, 215, 216, 218, 229..253 &lt; 223〉 η is a , G, c or t &lt; 400> 216

agcaggagcc tgagccttgg gaacatgcgt gtgacctcca cagctacctc ttctatggac tggtnnnnnn nnnnnnnnnn cactgtggga ctcttcttaa cttaaatttt aatttattta tactatttag tttttgtaat ttattttcga tttcacagtg tgtttgtgat tgtttgctct gagagttccc ctgtcccctc cncnttccct cacanngngt ctggtgacnn nnnnnnnnnn nnnnnnnnnn nnngtaggca gtcatggcac caaagccacc agactgacaa atgtgtatcg gatgcttttg ttcagggctg tgatcggcct ggggaaataa ta &lt;210&gt; 217 &lt;211&gt; 503 &lt;212&gt; DNA &lt;213〉人類agcaggagcc tgagccttgg gaacatgcgt gtgacctcca cagctacctc ttctatggac tggtnnnnnn nnnnnnnnnn cactgtggga ctcttcttaa cttaaatttt aatttattta tactatttag tttttgtaat ttattttcga tttcacagtg tgtttgtgat tgtttgctct gagagttccc ctgtcccctc cncnttccct cacanngngt ctggtgacnn nnnnnnnnnn nnnnnnnnnn nnngtaggca gtcatggcac caaagccacc agactgacaa atgtgtatcg gatgcttttg ttcagggctg tgatcggcct ggggaaataa ta &lt; 210 &gt; 217 &lt; 211 &gt; 503 &lt; 212 &gt; DNA &lt; 213〉 Human

&lt;220〉 &lt;223〉 Probe 36149—at HG-U95Av2 &lt;220&gt; &lt;221&gt; mi sc一feature &lt;222〉 130·.144, 254, 255, 273·.275, 280..288, 323, 419, 423, 428 &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 217 tgggcagcca gcattcattg taagttccct ctttgaaaac tggtgtgtgg gtgttcagtt 98677.doc -168- 120 200533758 180 240 300 360 420 480 503&lt; 220〉 &lt; 223〉 Probe 36149-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222> 130 · .144, 254, 255, 273 · 275, 280..288, 323, 419, 423, 428 &lt; 223〉 n is a, g, c or t &lt; 400 &gt; 217 tgggcagcca gcattcattg taagttccct ctttgaaaac tggtgtgtgg gtgttcagtt 98677.doc -168- 120 200533758 180 240 300 360 420 480 503

ctgtgtctgg tgggtatgga cagacagtaa tctcctgtga tctgtgctag ctgtgaggca gctctggaan nnnnnnnnnn nnnnggtttg aaccgtgaac aaaactgtgt tttgagttta gctgacatta aagaaaaaag ttcatcacgt gactgttaat gtaaacctgg ttattaaaat aactatgaaa ttannaaaaa aaaaaaaaaa aannnaaaan nnnnnnnnat ttaaaacagg agaaatctgg taagttgtta ggnttctaaa ttccttttag tctgttcact gagatattaa atttcagtag acagaaccca aaaagagatt tcatttcttt ctaatcactt tggcttctnt ctnttttntt aagtaggtaa aaaccttcct tggtgggcac ctaagcagga tgcagccaat tagttcatga acccagctgc gga &lt;210〉 218 &lt;211&gt; 455 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 36156_at HG-U95Av2 &lt;221&gt; misc_feature &lt;222〉 194..224, 343, 411， 412 &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 218 taagtccttt caattccacc agggccagag cagctccacc actgtgcact tagccatgat 60 ggcaacagaa accaagagac acaattacgc aggtatttag aagcagaggg acaaccagaa 120 ggcccttaac tatcaccagt gcatcacatc tgcacactct cttctccatt ccctagcagg 180 98677.doc -169- 200533758 aacttctagc tcannnnnnn nnnnnnnnnn nnnnnnnnnn nnnntttcag ctagacaatg atttggccag gcctagtaac caaggccctg tctctggcta ctccctggac cacgaggctg attcctctca tttccagctt ctcagtttct gcctgggcaa tgnccagggg ccaggagtgg ggagagttgt gatggagggg agaggggtca cacccacccc ctgcctggtt nntaggctgc tgcacaccaa ggccctgcat ctgtctgctc tgcat &lt;210〉 219 &lt;211&gt; 526 W &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 36175—s_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 30, 53, 54, 57, 154， 195, 223, 232 &lt;223&gt; n 為 a，g，c 或 tctgtgtctgg tgggtatgga cagacagtaa tctcctgtga tctgtgctag ctgtgaggca gctctggaan nnnnnnnnnn nnnnggtttg aaccgtgaac aaaactgtgt tttgagttta gctgacatta aagaaaaaag ttcatcacgt gactgttaat gtaaacctgg ttattaaaat aactatgaaa ttannaaaaa aaaaaaaaaa aannnaaaan nnnnnnnnat ttaaaacagg agaaatctgg taagttgtta ggnttctaaa ttccttttag tctgttcact gagatattaa atttcagtag acagaaccca aaaagagatt tcatttcttt ctaatcactt tggcttctnt ctnttttntt aagtaggtaa aaaccttcct tggtgggcac ctaagcagga tgcagccaat tagttcatga acccagctgc gga &lt; 210> 218 &lt; 211 &gt; 455 &lt; 212〉 DNA &lt; 213〉 human &lt; 220〉 &lt; 223 &gt; Probe 36156_at HG-U95Av2 &lt; 221 &gt; misc_feature &lt; 222> 194..224, 343, 411, 412 &lt; 223 > n is a, g, c or t &lt; 400 &gt; 218 taagtccttt caattccacc agggccagag cagctccacc actgtgcact tagccatgat 60 ggcaacagaa accaagagac acaattacgc aggtatttag aagcagaggg acaaccagaa 120 ggcccttaac tatcaccagt gcatcacatc tgcacactct cttctccatt ccctagcagg 180 98677.doc -169- 200533758 aacttctagc tcannnnnnn nnnnnnnnnn nnnnnnnnnn nnnntttcag c tagacaatg atttggccag gcctagtaac caaggccctg tctctggcta ctccctggac cacgaggctg attcctctca tttccagctt ctcagtttct gcctgggcaa tgnccagggg ccaggagtgg ggagagttgt gatggagggg agaggggtca cacccacccc ctgcctggtt nntaggctgc tgcacaccaa ggccctgcat ctgtctgctc tgcat &lt; 210> 219 &lt; 211 &gt; 526 W &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 36175—s_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 30, 53, 54, 57, 154, 195, 223, 232 &lt; 223 &gt; n is a, g, c or t

&lt;220〉 &lt;221&gt; &lt;222〉 misc_feature 242, 253, 263, 485, 486, 488 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 219 tagagcttgg gagaagacct aaggctacac gatggagacc ttatcggccg gggcttagca agagggtcgc tgctncccca gcccggtggn atctccttag acttggactc gctcttcctg ttggcaggca ttcttgctac tganggttgg tcagccggtt gtgctgtgcg acaggatggt gtgtggaagg tancatggga ctnntcnatg gactggaact gggaaaaggg ancagggtta 98677.doc 170- 300 200533758 360 420 480 526 ancatctgtg ttnaggggag gtncacctta ccctttttca taggggaaga gtgtcacact cctggctatc tcagggggaa tggggaaaag aatctttcaa gggcaaagaa ctcgtgggag gatgtctgtt gtatgtaata ctcacaatgg cttttggtta gtgttgaagg tgggaagagc atttgtaggt ccagaagagt gaaagagagg gaggggtgca gcaacatgtg cacaggcacg cacanntntg cacgcacaca tacaatctgg gttatctttg tgctat &lt;210&gt; 220 9 &lt;211&gt; 594 &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 36215^at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 53, 117, 353..375, 480..507 &lt;223&gt; n 為 a, g, c 或 t &lt;400&gt; 220 gtctgatcga ttttttttgc acatttagtt tctttgcttt acaacacacg atttattttt tcatgcagat caactgactt cagtgtttgt taattttccc agaagagtta aatcaagctg acaatgttgg aacaacattg tgagaatcca catctgattt aactgggttc atcttaatgt tatttgagag ctgtcaggtg tggcttaacc tatctctgcg attttaatga atataatcat gttagttttt gaaatttcaa cacttgtttt tttcagtgac tcaatttacc tctatttgct ttncctacac gcacttntgc gctatttttt ctaccttaaa tgcatataaa ttnnnnnnnn 60 120 180 240 300 360 98677.doc -171 - 200533758 nnnnnnnnnn aagacataaa nnnnnnnnnn atatttaaaa nnnnnaacac aaaaacctgt nnnnnnnnnn cgtgcaagaa cacttctttt ctgagatgtt nnnnnnngta aaaaataaaa catctgtacc ctttctacca aatgctgata tactctgctc acaccctggt atctatatgt ttgatttcac tagcaagttt gaaacctttg ctttcggttn tggtccatct tgtg&lt; 220〉 &lt; 221 &gt; &lt; 222〉 misc_feature 242, 253, 263, 485, 486, 488 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 219 tagagcttgg gagaagacct aaggctacac gatggagacc ttatcggcag tgctctggct gcccggtggn atctccttag acttggactc gctcttcctg ttggcaggca ttcttgctac tganggttgg tcagccggtt gtgctgtgcg acaggatggt gtgtggaagg tancatggga ctnntcnatg gactggaact gggaaaaggg ancagggtta 98677.doc 170- 300 200533758 360 420 480 526 ancatctgtg ttnaggggag gtncacctta ccctttttca taggggaaga gtgtcacact cctggctatc tcagggggaa tggggaaaag aatctttcaa gggcaaagaa ctcgtgggag gatgtctgtt gtatgtaata ctcacaatgg cttttggtta gtgttgaagg tgggaagagc atttgtaggt ccagaagagt gaaagagagg gaggggtgca gcaacatgtg cacaggcacg cacanntntg cacgcacaca tacaatctgg gttatctttg tgctat &lt; 210 &gt; 220 9 &lt; 211 &gt; 594 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 36215 ^ at HG-U95Av2 &lt; 220> &lt; 220> misc-feature &lt; 222 &gt; 53, 117, 353..375, 480..507 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 220 gtctgat cga ttttttttgc acatttagtt tctttgcttt acaacacacg atttattttt tcatgcagat caactgactt cagtgtttgt taattttccc agaagagtta aatcaagctg acaatgttgg aacaacattg tgagaatcca catctgattt aactgggttc atcttaatgt tatttgagag ctgtcaggtg tggcttaacc tatctctgcg attttaatga atataatcat gttagttttt gaaatttcaa cacttgtttt tttcagtgac tcaatttacc tctatttgct ttncctacac gcacttntgc gctatttttt ctaccttaaa tgcatataaa ttnnnnnnnn 60 120 180 240 300 360 98677.doc -171 - 200533758 nnnnnnnnnn aagacataaa nnnnnnnnnn atatttaaaa nnnnnaacac aaaaacctgt nnnnnnnnnn cgtgcaagaa cacttctttt ctgagatgtt nnnnnnngta aaaaataaaa catctgtacc ctttctacca aatgctgata tactctgctc acaccctggt atctatatgt ttgatttcac tagcaagttt gaaacctttg ctttcggttn tggtccatct tgtg

&lt;210〉 221 &lt;211&gt; 268 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 36227—at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 （220)..(241) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 221 鲁 taccaaaacc agtgaagtgt aagaaaccca gactgaactt accgtgagcg acaaagatga tttaaaaggg aagtctagag ttcctagtct ccctcacagc acagagaaga caaaattagc aaaaccccac tacacagtct gcaagattct gaaacattgc tttgaccact cttcctgagt tcagtggcac tcaacatgag tcaagagcat cctgcttctn nnnnnnnnnn nnnnnnnnnn ngtttaaggt gacccaatga ttcagcta &lt;210〉 222 &lt;211&gt; 322 98677.doc -172 - 200533758 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 36233一at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （64)..(65) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221〉 &lt;222〉 &lt;223〉&lt; 210〉 221 &lt; 211 &gt; 268 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 36227-at HG-U95Av2 &lt; 220> &lt; 221〉 misc_feature &lt; 222〉 (220 ) .. (241) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 221 Lu taccaaaacc agtgaagtgt aagaaaccca gactgaactt accgtgagcg acaaagatga tttaaaaggg aagtctagag ttcctagtct ccctcacagc acagagaaga caaaattagc aaaaccccac tacacagtct gcaagattct gaaacattgc tttgaccact cttcctgagt tcagtggcac tcaacatgag tcaagagcat cctgcttctn nnnnnnnnnn nnnnnnnnnn ngtttaaggt gacccaatga ttcagcta &lt; 210〉 222 &lt; 211 &gt; 322 98677.doc -172-200533758 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 36233-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 (64) .. (65) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221〉 &lt; 222〉 &lt; 223〉

misc一feature (206)..(232) n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc__feature &lt;222〉 （296)..(297) &lt;223〉n 為 a，g，c 或 t &lt;400〉 222 60 120 180 240 300 _ ctgaaaccaa gaaggatctg tatgaaccca ctcatggggg caaggtcttg agcatggccc ctgnnctcac ctctgtggaa atcattccat tccgagtggc tgcctacaac aaagccaaaa aagccatgga cttctatgat ccagcaaggc acaatgagtt tgacttcatc tcaggaactc gaatgaggaa gctcgcccgg gaaggnnnnn nnnnnnnnnn nnnnnnnnnn nnccccaaag catggaaggt cctgacagat tattacaggt ccctggagaa gaactaagcc tttggnncca gagtttcttt ctgaagtgct ct 98677.doc -173 - 322 200533758 &lt;210&gt; 223 &lt;211〉 482 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 36314_at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 49， 156， 162·.177, 285..369, 438 &lt;223&gt; n 為 a，g，c 或 tmisc-feature (206) .. (232) n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc__feature &lt; 222〉 (296) .. (297) &lt; 223〉 n is a, g , c, or t &lt; 400> 222 60 120 180 240 300 _ ctgaaaccaa gaaggatctg tatgaaccca ctcatggggg caaggtcttg agcatggccc ctgnnctcac ctctgtggaa atcattccat tccgagtggc tgcctacaac aaagccaaaa aagccatgga cttctatgat ccagcaaggc acaatgagtt tgacttcatc tcaggaactc gaatgaggaa gctcgcccgg gaaggnnnnn nnnnnnnnnn nnnnnnnnnn nnccccaaag catggaaggt cctgacagat tattacaggt ccctggagaa gaactaagcc tttggnncca gagtttcttt ctgaagtgct ct 98677. doc -173-322 200533758 &lt; 210 &gt; 223 &lt; 211〉 482 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 36314_at HG-U95Av2 &lt; 220> &lt; 221 &gt; mi sc 一feature &lt; 222〉 49, 156, 162 · .177, 285..369, 438 &lt; 223 &gt; n is a, g, c or t

&lt;400&gt; 223 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccnt gccaccccca tggagtcccc ggcccctgga ggccacagcc ccgacagccc cgcagccccc tctgctcctc ctactgctgc tgcccgtggg cctcctgctg ctggcngctg cnnnnnnnnn nnnnnnncag aggacgcggc ggaggacacc ccgccctggg gagcaggtgc cccccgtccc cagtccccag gacctgctgc ttgtggagca ctgacctggc caaggcctca tcctnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc ccttccttgg gcccctctca ttccctcccc agaatggagg caacgccaga atccagcacc ggccccantt acccaactct gtacaaagcc cttgtcccca tgaaattgta ta &lt;210〉 224 &lt;211〉 509 &lt;212&gt; DNA &lt;213&gt;人類 60 120 180 240 300 360 420 480 482 98677.doc -174- 200533758 &lt;220〉 &lt;223&gt; Probe 36344_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （94)..(125) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt;misc_feature &lt;222〉 （259)..(259) 擊 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221〉 misc一feature &lt;222〉 （348)..(376) &lt;223&gt; n 為 a，g，c 或 tggccccantt acccaactct 223 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccnt gccaccccca tggagtcccc ggcccctgga ggccacagcc ccgacagccc cgcagccccc tctgctcctc ctactgctgc tgcccgtggg cctcctgctg ctggcngctg cnnnnnnnnn nnnnnnncag aggacgcggc ggaggacacc ccgccctggg gagcaggtgc cccccgtccc cagtccccag gacctgctgc ttgtggagca ctgacctggc caaggcctca tcctnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc ccttccttgg gcccctctca ttccctcccc agaatggagg caacgccaga atccagcacc; &lt; 400 & gt gtacaaagcc cttgtcccca tgaaattgta ta &lt; 210〉 224 &lt; 211〉 509 &lt; 212 &gt; DNA &lt; 213 &gt; human 60 120 180 240 300 360 420 480 482 98677.doc -174- 200533758 &lt; 220〉 &lt; 223 &gt; Probe 36344_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222〉 (94) .. (125) &lt; 223 &gt; n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 (259) .. (259) Click &lt; 223〉 n is a, g, c or t &lt; 220〉 &lt; 221〉 misc-feature &lt; 222〉 (348) .. (376) &lt; 223 &gt; n is a, g, c or t

&lt;400&gt; 224 tttgcctgag cagctcttgg tgggagacat gttcaattac ttcctctctc tggccattgg 60 ggtctttctg ttcccagcct tcctcacagc ctcnnnnnnn nnnnnnnnnn nnnnnnnnnn 120 nnnnncttct gccatggatg aaaactcaga gaagaaaagg aagagggcca tcaaactcat 180 tgtcactgtc ctggccatgt acctgatctg cttcactcct agtaaccttc tgcttgtggt 240 gcattatttt ctgattaana gccagggcca gagccatgtc tatgccctgt acattgtagc 300 cctctgcctc tctaccctta acagctgcat cgaccccttt gtctattnnn nnnnnnnnnn 360 nnnnnnnnnn nnnnnngcaa agaacgctct cctttgccga agtgtccgca ctgtaaagca 420 gatgcaagta tccctcacct caaagaaaca ctccaggaaa tccagctctt actcttcaag 480 98677.doc -175- 200533758 ttcaaccact gttaagacct cctattgag 509 &lt;210&gt; 225 &lt;211&gt; 111 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 36345—g—at HG-U95Av2agaacgctct 224 tttgcctgag cagctcttgg tgggagacat gttcaattac ttcctctctc tggccattgg 60 ggtctttctg ttcccagcct tcctcacagc ctcnnnnnnn nnnnnnnnnn nnnnnnnnnn 120 nnnnncttct gccatggatg aaaactcaga gaagaaaagg aagagggcca tcaaactcat 180 tgtcactgtc ctggccatgt acctgatctg cttcactcct agtaaccttc tgcttgtggt 240 gcattatttt ctgattaana gccagggcca gagccatgtc tatgccctgt acattgtagc 300 cctctgcctc tctaccctta acagctgcat cgaccccttt gtctattnnn nnnnnnnnnn 360 nnnnnnnnnn nnnnnngcaa; &lt; 400 & gt cctttgccga agtgtccgca ctgtaaagca 420 gatgcaagta tccctcacct caaagaaaca ctccaggaaa tccagctctt actcttcaag 480 98677.doc -175- 200533758 ttcaaccact gttaagacct cctattgag 509 &lt; 210 &gt; 225 &lt; 211 &lt; 211 &lt; 211 Probe 36345—g—at HG-U95Av2

&lt;400〉 225 tgttaagacc tcctattgag ttttccaggt cctcagatgg gaattgcaca gtaggatgtg gaacctgttt aatgttatga ggacgtgtct gttatttcct aatcaaaaag g 60 111 &lt;210&gt; 226 &lt;211&gt; 437 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 36377_at HG-U95Av2&lt; 400〉 225 tgttaagacc tcctattgag ttttccaggt cctcagatgg gaattgcaca gtaggatgtg gaacctgttt aatgttatga ggacgtgtct gttatttcct aatcaaaaag g 60 111 &lt; 210 &gt; 226 &lt; 211 &gt; 437 &lt; 223 &lt; 212 -U95Av2

&lt;220&gt; &lt;221〉 misc一feature &lt;222〉 （138)·.(178) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 226 ggcgaaagat atctctccat tgtgcatctg cctcttttga cgttggaaga cacatgtctt actccccaaa gggagcccag cactgggagc cttcttgatg atctcaaaaa taatagctat tcaagaaaat caccaagnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntg 60 120 986^7.doc -176- 180 200533758 ggagcaacat gatattactg gtagtgctta atagctcata attgctattg gaatgttcta aaaaccaaaa caattttgtg ttttatgtgt catagtc caaaagttta aagagtgaga taccaactgg gaaaacatgt aagcagagat ttgtcagtgt atgactaaaa tagtgaacat tgtttcaaat aagaatgtga agagtaaaat atataatcaa gggtgtagta tttaatgttt aatttaatta aatagatttc&lt; 220 &gt; &lt; 221〉 misc-feature &lt; 222〉 (138) ·. (178) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 226 ggcgaaagat atctctccat tgtgcatctg cctcttttga cgttggaaga cacatgtctt actccccagggggg cttcttgatg atctcaaaaa taatagctat tcaagaaaat caccaagnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntg 60 120 986 ^ 7.doc -176- 180 200533758 ggagcaacat gatattactg gtagtgctta atagctcata attgctattg gaatgttcta aaaaccaaaa caattttgtg ttttatgtgt catagtc caaaagttta aagagtgaga taccaactgg gaaaacatgt aagcagagat ttgtcagtgt atgactaaaa tagtgaacat tgtttcaaat aagaatgtga agagtaaaat atataatcaa gggtgtagta tttaatgttt aatttaatta aatagatttc

&lt;210〉 227 &lt;211&gt; 82 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 36445—at HG-U95Av2 &lt;400&gt; 227 cagtacttct ggacatgctc tggaggagaa agattggtcc tcagatgacc ctttctcatg ctgcaggatt ccatgctact ag &lt;210〉 228 &lt;211〉 290 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 36543—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （134)..(151) &lt;223&gt; n 為 a，g，c 或 t 98677.doc 177- 60 200533758 &lt;400&gt; 228 gggtgcattt ctaggacttt ttttcaggaa tacatttgga tgcaggagac attnnnnnnn tgacttaagt ggcattaaac actacagagt ttatgattta tctaacatat gtctataata aattcaaaac aattggcaaa nnnnnnnnnn nctaatatgc atttgagagc taactatatt aggtacttaa agcttctatg tagtgtttag gttctttttt ctttgtatta atgtgttaag tttacaatct gcactttaac tttataagac tactatacaa gttgacattg 120 180 240 290 &lt;210&gt; 229 &lt;211&gt; 484 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 36550—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （284)..(304) 鲁 &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （316),.(336) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （36)·.(36) &lt;223&gt; n 為 a，g，c 或 t 98677.doc -178 - 200533758 &lt;400&gt; 229 ggaaccacct atgcttaaaa tactgtaaat atgcantgag gtttggcaaa atctattcca tgtgtgattt gcttgtagaa acaattttga aagccccttg aggaaaataa aaatcaagaa gaacactttt ctcccttttc catacaaatt aaaacttaac agcatcaaat tattgggacc agaaaccaag taatgtataa tgtggctttt gttgagttaa ataagatgct atataatgga gaagaatttg aaaatgcaca aaaaaatcaa tctacattat cagnnnnnnn nnnnnnnnnn&lt; 210> 227 &lt; 211 &gt; 82 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 36445-at HG-U95Av2 &lt; 400 &gt; 227 cagtacttct ggacatgctc tggaggagaa agattggtcc tcagatg cctgctctctctctctctctctct ; 210〉 228 &lt; 211〉 290 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 36543—at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 (134) .. (151) &lt; 223 &gt; n is a, g, c or t 98677.doc 177- 60 200533758 &lt; 400 &gt; 228 gggtgcattt ctaggacttt ttttcaggaa tacatttgga tgcaggagac attnnnnnnn tgacttaagt ggcattaaac actacagagt ttatgattta tctaacatat gtctataata aattcaaaac aattggcaaa nnnnnnnnnn nctaatatgc atttgagagc taactatatt aggtacttaa agcttctatg tagtgtttag gttctttttt ctttgtatta atgtgttaag tttacaatct gcactttaac tttataagac tactatacaa gttgacattg 120 180 240 290 &lt; 210 &gt; 229 &lt; 211 &gt; 484 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220> &ltat; 223-HG-UU-350-UU 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (284) .. (304) Lu &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (316),. (336) &lt; 223 &gt; n is a, g, c or t &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (36) ·. (36) &lt; 223 &gt; n is a, g, c or t 98677.doc -178-200533758 &lt; 400 &gt; 229 ggaaccacct atgcttaaaa tactgtaaat atgcantgag gtttggcaaa atctattcca tgtgtgtatt gct aagccccttg aggaaaataa aaatcaagaa gaacactttt ctcccttttc catacaaatt aaaacttaac agcatcaaat tattgggacc agaaaccaag taatgtataa tgtggctttt gttgagttaa ataagatgct atataatgga gaagaattnnnn nnn aaaatca

nnnntatgtt aaatannnnn nnnnnnnnnn nnnnnnaact atgagggtct tgtatccacg taacacaggt agttacaaaa acatgttatt gtactgtgta aagatgcata gtcatctcat ttggttggct ttgtaccttg tacctttttt agccttggct tttgttgaac tagaaccctc agca &lt;210&gt; 230 &lt;211〉 145 &lt;212〉 DNA φ &lt;2丨3&gt;人類 &lt;220&gt; &lt;223〉 Probe 36564—at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 （57)..(82) &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 230 gcaccgagcc caagtgccca tatgaacctc tctgccctag ccgagggaca aactgtnnnn 98677.doc -179- 200533758 nnnnnnnnnn nnnnnnnnnn nnagagtatg aagtggaatg aatgctcctg ttctgagaag cacacttgta actgcatctt ttgga 120 145 &lt;210&gt; 231 &lt;211&gt; 566 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉nnnntatgtt aaatannnnn nnnnnnnnnn nnnnnnaact atgagggtct tgtatccacg taacacaggt agttacaaaa acatgttatt gtactgtgta aagatgcata gtcatctcat ttggttggct lt &lt;220; &lt; &lt; &lt; &lt; &gt; &gt; &lt; &lt; &lt; &gt; &lt; &lt; &lt; &gt; &lt; &lt; &gt; &gt; Probe 36564-at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222〉 (57) .. (82) &lt; 223> n is a, g, c or t &lt; 400 &gt; 230 gcaccgagcc caagtgccca tatgaacctc tctgccctag ccgagggaca aactgtnnnn 98677.doc -179- 200533758 nnnnnnnnnnnn nnnnnnnnnn nnagagtatg aagtggaatg aatgctcctg ttctgagaag cacacttgta actgcatctt ttgga 120 145 &lt; 210 &gt; 231 &lt; 211 &gt; DNA

&lt;223&gt; Probe 36578_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （230)..(248) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （339)·.(371) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 231 60 120 180 240 300 tatgccagga atgtgcccct tctctaagaa aatgccctat ttgcaggggt ataatcaagg gtactgttcg tacatttctc tcttaaagaa aaatagtcta tattttaacc tgcataaaaa ggtctttaaa atattgttga acacttgaag ccatctaaag taaaaaggga attatgagtt tttcaattag taacatteat gttetagtet getttggtac taataatctn nnnnnnnnnn nnnnnnnntc atatatttaa tettaatetg tttatttaca agggaagatt tatgtttggt gaactatatt agtatgtatg tgtacctaag ggagtagtnn nnnnnnnnnn nnnnnnnnnn 98677.doc -180 - 360 200533758 nnnnnnnnnn agaaaagaac ttggtgcttt gtgagaaaca nactggattt tggaaaccag tcacttgtgt tctcaataaa gttgttcttt gaactctgga tttaaaataa gtgctt cagaaagctt gttcatcaga ggatttttct tgaatactaa gttatggtgc cttatttctc attatagtgt cgaattgtct cccctagttt&lt; 223 &gt; Probe 36578_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222> (230) .. (248) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (339) ·. (371) &lt; 223 &gt; n is a, g, c or t &lt; 400> 231 60 120 180 240 300 tatgccagga atgtgcccct tctctaagaa aatgccctat ttgcaggggt tacata taatcaagg gtactgttcg tagata tacata atattgttga acacttgaag ccatctaaag taaaaaggga attatgagtt tttcaattag taacatteat gttetagtet getttggtac taataatctn nnnnnnnnnn nnnnnnnntc atatatttaa tettaatetg tttatttaca agggaagatt tatgtttggt gaactatatt agtatgtatg tgtacctaag ggagtagtnn nnnnnnnnnn nnnnnnnnnn 98677.doc -180 - 360 200533758 nnnnnnnnnn agaaaagaac ttggtgcttt gtgagaaaca nactggattt tggaaaccag tcacttgtgt tctcaataaa gttgttcttt gaactctgga tttaaaataa gtgctt cagaaagctt gttcatcaga ggatttttct tgaatactaa gttatggtgc cttatttctc attatagtgt cgaattgtct cccctagttt

&lt;210&gt; 232 &lt;211&gt; 447 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 36600_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 34, 89， 173..187, 357·.395, 399..415 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 232 cagatacctc ggattgagga tggtaacaat tttnggagtg gctgtccagg agaaggtgtt tgagctgatg accagcctcc acaccaagnc tagaaggctt ccacactcaa atctctaagt atttctctga gcgtggtgat gcagtgacta aagcagccaa gcagccccat gtnnnnnnnn nnnnnnngct ggtgcacgag ctggatgagg cagagtaccg ggacatccgg ctgatggtca tggagatccg caatgcttat gctgtgttat atgacatcat cctgaagaac ttcgagaagc tcaagaagcc caggggagaa acaaagggaa tgatctattg agagccctct ctcccannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntggnn nnnnnnnnnn nnnnncaaac 98677.doc -181 - 200533758 ttgcttctgt tgagattttt ccctcac &lt;210〉 233 &lt;211&gt; 481 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36658_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 81..100, 158, 195, 235, 237..273, 275, 456 &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 233 gaccttatcc acaacccggg gcttggaaag gaaggtattt tggaatcaca ccctccggtt atgttgctcc agtaaaatct nnnnnnnnnn nnnnnnnnnn ttcttagcat ggtgagctga gttcatggct tttttttgta gccagtcctg tccctggncc atccatgtga tggttttgga tggagttaaa cttgnatgcc agtgggcagt gcatgtggaa agtatcagag taagncnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnanggttt tctttagaat cagaattgta gccagtttct ttggccagaa ggatgaatac ttggatatta ctgaaaggga ggggtggaga tgggtgtggc agtgtatggt gtgtgatttt tattttcttc tttggtcatg ggggccaagg agaaaggcat gaatcttccc tgtcaggctc ttacanccac aggcactgtg tctactgtct g 447&lt; 210 &gt; 232 &lt; 211 &gt; 447 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 36600_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222> 34, 89, 173..187, 357 · .395, 399..415 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 232 cagatacctc ggattgagga tggtaacaat tttnggagtg gctgtccagg ccaggt nggagt agcact agg actg ag cct ag gt nnnnnnngct ggtgcacgag ctggatgagg cagagtaccg ggacatccgg ctgatggtca tggagatccg caatgcttat gctgtgttat atgacatcat cctgaagaac ttcgagaagc tcaagaagcc caggggagaa acaaagggaa tgatctattg agagccctct ctcccannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntggnn nnnnnnnnnn nnnnncaaac 98677.doc -181 - 200533758 ttgcttctgt tgagattttt ccctcac &lt; 210> 233 &lt; 211 &gt; 481 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 36658_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; 81..100, 158, 195, 235, 237..273, 275, 456 &lt; 223 &gt; n is a, g c or t &lt; 400> 233 gaccttatcc acaacccggg gcttggaaag gaaggtattt tggaatcaca ccctccggtt atgttgctcc agtaaaatct nnnnnnnnnn nnnnnnnnnn ttcttagcat ggtgagctga gttcatggct tttttttgta gccagtcctg tccctggncc atccatgtga tggttttgga tggagttaaa cttgnatgcc agtgggcagt gcatgtggaa agtatcagag taagncnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnanggttt tctttagaat cagaattgta gccagtttct ttggccagaa ggatgaatac ttggatatta ctgaaaggga ggggtggaga tgggtgtggc agtgtatggt gtgtgatttt tattttcttc tttggtcatg ggggccaagg agaaaggcat gaatcttccc tgtcaggctc ttacanccac aggcactgtg tctactgtct g 447

60 120 180 240 300 360 420 480 481 98677.doc -182- 200533758 &lt;210&gt; 234 &lt;211〉 449 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36659_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 36, 46, 55, 56, 66, 735 80, 915 92， 102， 113, 120， 126, 131 &lt;223〉 n 為 a，g，c 或 t60 120 180 240 300 360 420 480 481 98677.doc -182- 200533758 &lt; 210 &gt; 234 &lt; 211〉 449 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 36659_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 36, 46, 55, 56, 66, 735 80, 915 92, 102, 113, 120, 126, 131 &lt; 223> n is a, g, c or t

&lt;220&gt; &lt;221&gt; misc__feature &lt;222〉 133， 145， 152， 162， 173， 178, 204, 215, 216, 222, 315, 328, 392 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 234 acagacgaga caacagcaca caggcagcca gccgtnggcc agaggntcga ggggnnctca 60 ggggcntcag gcnacccgtn ccccacacga nngggccccg tngggtgggc ctnggccctn 120 gctttnctac ngnccaatgt tatgnccagc tnccatgttc tncccaaata ccngttgnat 180&lt; 220 &gt; &lt; 221 &gt; misc__feature &lt; 222〉 133, 145, 152, 162, 173, 178, 204, 215, 216, 222, 315, 328, 392 &lt; 223 &gt; n is a, g, c or t &lt; 400> 234 acagacgaga caacagcaca caggcagcca gccgtnggcc agaggntcga ggggnnctca 60 ggggcntcag gcnacccgtn ccccacacga nngggccccg tngggtgggcc ctnggccctn 120 gctttnctac ngnct ctngat ctacat tnct

gtgaattatt ttaaaggcaa aacngtgctc tttanntttt anaaaacact gataatcaca 240 ctgcggtagg tcattctttt gccacatccc tatagaccac tgggtttggc aaaactcagg 300 cagaagtgga gaccnttcta gacatcantg tcagccttgc tacttgaagg tacaccccat 360 agggtcggag gtgctgtccc cactgcccca cnttgtccct gagatttaac ccctccactg 420 ctgggggtga gctgtactct tctgactgc 449 &lt;210&gt; 235 98677.doc 183 - 200533758 &lt;211&gt; 471 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 36690—at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 （99)..(115) &lt;223〉為 a，g，c 或 tgtgaattatt ttaaaggcaa aacngtgctc tttanntttt anaaaacact gataatcaca 240 ctgcggtagg tcattctttt gccacatccc tatagaccac tgggtttggc aaaactcagg 300 cagaagtgga gaccnttcta gacatcantg tcagccttgc tacttgaagg tacaccccat 360 agggtcggag gtgctgtccc cactgcccca cnttgtccct gagatttaac ccctccactg 420 ctgggggtga gctgtactct tctgactgc 449 &lt; 210 &gt; 235 98677.doc 183 - 200533758 &lt; 211 &gt; 471 &lt; 212 &gt; DNA &lt; 213> Human &lt; 220> &lt; 223 &gt; Probe 36690-at HG-U95Av2 &lt; 220> &lt; 221 &gt; mi sc-feature &lt; 222> (99) .. (115) &lt; 223 > For a, g, c or t

&lt;221〉 misc_feature &lt;222〉 （376)..(391) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （324)..(324) &lt;223&gt; n 為 a，g，c 或 t • &lt;400〉 235 gactattttc aagcaacctg gtccacccag gattagtgac caggttttca ggaaaggatt tgcttctctc tagaaaatgt ctgaaaggat tttattttnn nnnnnnnnnn nnnnngaaaa taccctcctc aaataacttg cttaactaca tatagattca agtgtgtcaa tattctattt tgtatattaa atgctatata atggggacaa atctatatta tactgtgtat ggcattatta agaagctttt tcattatttt ttatcacagt aattttaaaa tgtgtaaaaa ttaaaaccag tgactcctgt ttaaaaataa aagntgtagt tttttattca tgctgaataa taatctgtag 60 120 180 240 300 98677.doc -184- 360 200533758 ttaaaaaaaa agtgtnnnnn nnnnnnnnnn ntgaaatgtc agactgtaaa accttgtgtg gaaatgttta acttttattt tttcatttaa atttgctgtt ctggtattac c &lt;210〉 236 &lt;211&gt; 356 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36691一at HG-U95Av2&lt; 221〉 misc_feature &lt; 222〉 (376) .. (391) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (324) .. (324) ) &lt; 223 &gt; n is a, g, c or t • &lt; 400> 235 gactattttc aagcaacctg gtccacccag gattagtgac caggttttca ggaaaggatt tgcttctctc ctgaaaggat tttattttnn nnnnnnnnnn nnnnngaaaa taccctcctc aaataacttg cttaactaca tatagattca agtgtgtcaa tattctattt tgtatattaa atgctatata atggggacaa atctatatta tactgtgtat ggcattatta agaagctttt tcattatttt ttatcacagt aattttaaaa tgtgtaaaaa ttaaaaccag tagaaaatgt tgactcctgt ttaaaaataa aagntgtagt tttttattattca tgctgaataa taatctgtag 60 120 180 240 300 98677.doc -184- 360 200533758 ttaaaaaaaa &gt; 236 &236; &lt; 236 &lt; 236 &gt; algactgtaaa accttgtgtg gaaatgtttactttcttttttatttttttattttattttattttattttattttattttattttattttattttattttattttattttatttttttttatttttttttattttttttattttttttattttttttattttttttttttttttttttttttttttttttttttatttttttttatttttttattttttttattattca tgctgaataa taatctgtag 60 120 180 240 300 98677.doc -184- 360 200533758 ttaaaaaaaa &gt; &lt; 236 &gt; 236 Human &lt; 220 &gt; &lt; 223 &gt; Probe 36691-at HG-U95Av2

cttcagcgcc actggctgga aggtgggctg ggtcctgggt ccagatcaca tcatgaagca cctgcggacc gtgcaccaga actccgtctt ccactgcccc acgcagagcc aggctgcagt agccgagagc tttgaacggg agcagctgct cttccgccaa cccagcagct actttgtgca gttcccgcag gccatgcagc gctgccgtga ccacatgata cgtagcctac agtcagtggg cctgaagccc atcatccctc agggcagcta cttcctcatc acagacatct cagacttcaa gaggaagatg cctgacttgc ctggagctgt ggatgagccc tatgacagac gcttcgcttcagcgcc actggctgga aggtgggctg ggtcctgggt ccagatcaca tcatgaagca cctgcggacc gtgcaccaga actccgtctt ccactgcccc acgcagagcc aggctgcagt agccgagagc tttgaacggg agcagctgct cttccgccaa cccagcagct actttgtgca gttcccgcag gccatgcagc gctgccgtga ccacatgata cgtagcctac agtcagtggg cctgaagccc atcatccctc agggcagcta cttcctcatc acagacatct cagacttcaa gaggaagatg cctgacttgc ctggagctgt ggatgagccc tatgacagac gcttcg

&lt;210&gt; 237 &lt;211〉 221 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 36700一at HG-U95Av2 &lt;400&gt; 237 tacaaactgt gacctcagct tcagagtgtc agggcctcac ttgtatagaa tgtaatgttc 9867^.doc -185 - 200533758 tcctcaaaca tttatgttaa ctctataaac aaatatcgtt aagttaaaca agttttcaaa aacaaaacaa tttttaaagt accttaaaat tgaggatgtt actcagtgtt aacacatggg aacaccaaaa tattcaataa gcctggtcaa ttctatagtt a &lt;210〉 238 &lt;211〉 535 &lt;212〉 DNA &lt;213〉人類&lt; 210 &gt; 237 &lt; 211> 221 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223> Probe 36700-at HG-U95Av2 &lt; 400 &gt; 237 tacaaactgt gacctcagct tcagagtgtc agggcctcac ttgtatagat tgtaat. -185-200533758 tcctcaaaca tttatgttaa ctctataaac aaatatcgtt aagttaaaca agttttcaaa aacaaaacaa tttttaaagt accttaaaat tgaggatgtt actcagtgtt aacacatggg aacaccaaaa tattcaataa gcctggtcaa ttctltltltlt; 212; 535 &lt; 212

&lt;220〉 &lt;223&gt; Probe 3671Lat HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 39, 43, 44, 53, 62, 70, 74, 86, 113， 124 &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221〉 misc_feature &lt;222〉 127， 142， 148， 171..465 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 238 ttgcacggat ctaagttatt ctccccagcc agagcccgng ctnnctgctc ccngggaaaa gntggcgtan tggncctgag ctgggnttta tattttatat ctgcaaataa atnacatttt atcntanatt tagggaaagc cngagagnaa caacaaaaaa tgtttaagcc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 98677.doc -186- 200533758 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntattg cccggctcct 480 agaatttatt tatttcctga cttacagcaa gcgagttatc gtcttctgta ttttg 535 &lt;210〉 239 &lt;211&gt; 452 &lt;212〉 DNA &lt;213&gt;人類&lt; 220> &lt; 223 &gt; Probe 3671Lat HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 39, 43, 44, 53, 62, 70, 74, 86, 113, 124 &lt; 223 &gt; n Is a, g, c or t &lt; 220〉 &lt; 221〉 misc_feature &lt; 222〉 127, 142, 148, 171..465 &lt; 223 &gt; n is a, g, c or t &lt; 400> 238 ttgcacggat ctaagttatt ctccccagcc agagcccgng ctnnctgctc ccngggaaaa gntggcgtan tggncctgag ctgggnttta tattttatat ctgcaaataa atnacatttt atcntanatt tagggaaagc cngagagnaa caacaaaaaa tgtttaagcc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 98677.doc -186- 200533758 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntattg cccggctcct 480 agaatttatt tatttcctga cttacagcaa gcgagttatc gtcttctgta ttttg 535 &lt; 210〉 239 &lt; 211 &gt; 452 &lt; 212> DNA &lt; 213 &gt;

&lt;223&gt; Probe 36767.at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc^feature &lt;222〉 （27)..(27) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 239 cagaggtagt ctcactgctt gaactangct gagcaatctg accctatggg tctaggacac 60 ^ agttcctggg aacatcacat tcctctgccc ttcctgcagg caggaacaaa cagggctgcc 120 ttctggcctt gtaagaccct tattgctgtc ctggaggggc tggggacttg tgtctgcggg 180 gatcagagcg cacagggagt gcacatatcc aggcaccagg actagggctg gagtgagggg 240 ggggtatttc aattaccttc tattggtctc ccttctctac actcttgtaa taaaatgtct 300 atttttaatg tttgtacaca acaatccttc tattctagcc tgcattgagc ttgcatgctt 360 gcataagagc ttaagaacca ttgatttaat gtaataggga aaattctaac ccaggtatcc 420 aaaaatgtgt aagaacaact acctgagcta aa 452 &gt;8677.doc -187- 200533758 &lt;210&gt; 240 &lt;211&gt; 131 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 36790—at HG-U95Av2 &lt;220〉&lt; 223 &gt; Probe 36767.at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222> (27) .. (27) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 239 cagaggtagt ctcactgctt gaactangct gagcaatctg accctatggg tctaggacac 60 ^ agttcctggg aacatcacat tcctctgccc 120 ttctggcctt ttcctgcagg caggaacaaa cagggctgcc gtaagaccct tattgctgtc ctggaggggc tggggacttg tgtctgcggg 180 gatcagagcg cacagggagt gcacatatcc aggcaccagg actagggctg gagtgagggg 240 ggggtatttc aattaccttc tattggtctc ccttctctac actcttgtaa taaaatgtct 300 atttttaatg tttgtacaca acaatccttc tattctagcc tgcattgagc ttgcatgctt 360 gcataagagc ttaagaacca ttgatttaat gtaataggga aaattctaac ccaggtatcc 420 aaaaatgtgt aagaacaact acctgagcta aa 452 &gt; 8677.doc -187- 200533758 &lt; 210 &gt; 240 &lt; 211 &gt; 131 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 36790-at HG- U95Av2 &lt; 220〉

&lt;221〉 misc一feature &lt;222&gt; (39)..(39) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 240 gagaagttcc attcaaagtg ccaatgatag agtcaacang gaaggttaat gttggaaaca caatcaggtg tggattggtg ctactttgaa caaaaggtcc ccctgtggtc ttttgttcaa cattgtacaa t &lt;210〉 241 • &lt;211〉 404 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 36791—g—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （196)·.(200) &lt;223&gt; n 為 a，g，c 或 t 98677.doc 188-&lt; 221> misc-feature &lt; 222 &gt; (39) .. (39) &lt; 223 &gt; n is a, g, c or t &lt; 400> 240 gagaagttcc attcaaagtg ccaatgatag agtcaacang gaaggttaat gttggaaaca caatcaggtg tggattggt cgt actctt ctacttt t &lt; 210〉 241 • &lt; 211〉 404 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 36791—g-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (196) .. (200) &lt; 223 &gt; n is a, g, c or t 98677.doc 188-

200533758 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （310)..(310) &lt;223〉 η 為 a，g，c 或 t &lt;400〉 241 ctgagtttgc ggagaggtca gtaactaaat tggagaaaag cattgatgac ttagaagaga aagtggctca tgccaaagaa gaaaacctta gtatgcatca gatgctggat cagactttac tggagttaaa caacatgtga aaacctcctt agctgcgacc acattctttc attttgtttt gttttgtttt gttttnnnnn taaacacctg cttacccctt aaatgcaatt tatttacttt taccactgtc acagaaacat ccacaagata ccagctaggt cagggggtgg ggaaaacaca tacaaaaagn caagcccatg tcagggcgat cctggttcaa atgtgccatt tcccgggttg atgctgccac actttgtaga gagtttagca acacagtgtg ctta &lt;210&gt; 242 &lt;211〉 128 &lt;212&gt; DNA φ &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 36792^at HG-U95Av2 &lt;400&gt; 242 gaagaagttc cattcctttc tgattggcac acgtgcagct catgacaatc tgtaggataa caatcagtgt ggatttccac tcttttcagt ccttcatgtt aaagatttag acaccacata caactggt 60 120 180 240 300 360 404 60 120 128 98677.doc 189- 200533758 &lt;210〉 243 &lt;211&gt; 571 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 36825—at HG-U95Av2 &lt;220〉 &lt;221〉mi sc一feature &lt;222&gt; 74, 78, 453..468, 540, 542..545 &lt;223&gt; n 為 a, g，c 或 t200533758 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (310) .. (310) &lt; 223〉 η is a, g, c or t &lt; 400> 241 ctgagtttgc ggagaggtca gtaactaaat tggagaaaag cattgatgac ttagaagaga aagaccaga tagcat gatgctggat cagactttac tggagttaaa caacatgtga aaacctcctt agctgcgacc acattctttc attttgtttt gttttgtttt gttttnnnnn taaacacctg cttacccctt aaatgcaatt tatttacttt taccactgtc acagaaacat ccacaagata ccagctaggt cagggggtgg ggaaaacaca tacaaaaagn caagcccatg tcagggcgat cctggttcaa atgtgccatt tcccgggttg atgctgccac actttgtaga gagtttagca acacagtgtg ctta &lt; 210 &gt; 242 &lt; 211> 128 &lt; 212 &gt; DNA φ &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 36792 ^ at HG-U95Av2 &lt; 400 &gt; 242 gaagaagttc cattcctttc tgattggcac acgtgcagct catgacaatc tgtaggataa caatcagtgt ggatttccac tcttttcagt 120 ccttcatgt tac aac 404 200533758 &lt; 210> 243 &lt; 211 &gt; 571 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223> Probe 36825 --At HG-U95Av2 &lt; 220〉 &lt; 221〉 mi sc-feature &lt; 222 &gt; 74, 78, 453..468, 540, 542..545 &lt; 223 &gt; n is a, g, c or t

&lt;400〉 243 cttggtttca ctagtagtaa acattattat tttttttata tttgcaaagg aaacatatct 60 aatccttcct atangaanga acagtattgc tgtaattcct tttcttttct tcctcatttc 120 ctctgcccct taaaagattg aagaaagaga aacttgtcaa ctcatatcca cgttatctag 180 caaagtacat aagaatctat cactaagtaa tgtatccttc agaatgtgtt ggtttaccag 240 tgacacccca tattcatcac aaaattaaag caagaagtcc atagtaattt atttgctaat 300 agtggatttt taatgctcag agtttctgag gtcaaatttt atcttttcac ttacaagctc 360 tatgatctta aataatttac ttaatgtatt ttggtgtatt ttcctcaaat taatattggt 420 gttcaagact atatctaatt cctctgatca ctnnnnnnnn nnnnnnnnta ttaaatgtaa 480 ggcacttttc tatgaatttt aaatataaaa ataaatattg ttctgattat tactgaaaan 540 annnnagcca tttcaatgtc ttgggaaaca a 571 &lt;210〉 244 &lt;211&gt; 75 98677.doc -190 - 200533758 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 36852—at HG-U95Av2 &lt;400〉 244 ccacggctat ccttatagtg atctggactt tgagtgagaa gatgtgattt ggaccatggc acttaaaaac tctat&Lt; 400> 243 cttggtttca ctagtagtaa acattattat tttttttata tttgcaaagg aaacatatct 60 aatccttcct atangaanga acagtattgc tgtaattcct tttcttttct tcctcatttc 120 ctctgcccct taaaagattg aagaaagaga aacttgtcaa ctcatatcca cgttatctag 180 caaagtacat aagaatctat cactaagtaa tgtatccttc agaatgtgtt ggtttaccag 240 tgacacccca tattcatcac aaaattaaag caagaagtcc atagtaattt atttgctaat 300 agtggatttt taatgctcag agtttctgag gtcaaatttt atcttttcac ttacaagctc 360 tatgatctta aataatttac ttaatgtatt ttggtgtatt ttcctcaaat taatattggt 420 gttcaagact atatctaatt cctctgatca ctnnnnnnnn nnnnnnnnta ttaaatgtaa 480 ggcacttttc tatgaatttt aaatataaaa ataaatattg ttctgattat tactgaaaan 540 annnnagcca tttcaatgtc ttgggaaaca a 571 &lt; 210> 244 &lt; 211 &gt; 75 98677.doc -190 - 200533758 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 36852—at HG-U95Av2 &lt; 400〉 244 ccacggctat ccttatagtg atctggactt tgagtgagaa gatgtgattt ggaccatggc acttaaaaac tctat

&lt;210〉 245 &lt;211&gt; 397 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 36879—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 155， 168， 193, 306 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 245 cgagccctgt caggaggagc gcgctggtgc ggggtgggcg ctccgcgtgc gcgctngtac gctcgggaag tgctggcgcc tgcacgagct canagctgct accgggacgg tctccgaccg tcccgcagaa cgcagatggc cggggccggg ggtcgacgtg ccccgcgctc cgcgccattc cgccggcagc accgtggagc cgcanccgcg ggtcagaggc agcggcccgc gccgccccct tgctgcctcg tggtccgggc ctggggancc tgcgccgtgg agagccgcgc cgcccttcgc cgcccgggag gctgccgctg gctccgcctg gaccccctgg cctgcaggag agagctcgtt 98677.doc -191 - 200533758 ctgccgccgc agcaataaag ctcctttgcc gcgaaaa &lt;210&gt; 246 &lt;211〉 522 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36929_at HG-U95Av2 &lt;220&gt; &lt;221〉mi sc一feature &lt;222&gt; 106, 109, 165..235, 239, 243, 246..251, 323 &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 246 gtgcccggat ccagagtgtg aagacagagg cagaggagct gtttggggag accatggaga tgatggacag gatgaaagac atggagttgg agctgctgcg gggcanccna ggccatcatg ctgcgctcag cggacctgac aggactggag aagcgtgtgg agcannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngccng ttnccnnnnn natctgccgc ctttgctttt ggttgggggc agattgggtt ggaatgcttt ccatctccag gagactttca tgnagcctaa agtacagcct ggaccacccc tggtgtgtag ctagtaagat taccctgagc tgcagctgag cctgagccaa tgggacagtt acacttgaca gacaaagatg gtggagattg gcatgccatt gaaactaaga gctctcaagt caaggaagct gggctgggca gtatcccccg cctttagttc tccactgggg ag 397&lt; 210> 245 &lt; 211 &gt; 397 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 36879-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> 155, 168, 193, 306 &lt; 223 &gt; n is a, g, c or t &lt; 400> 245 cgagccctgt caggaggagc gcgctggtgc ggggtgggcg ctccgcgtgc gcgctngtac gctcgggaag tgctggcgcc tgcacgagct canagctgct accgggacgg tctccgaccg tcccgcagaa cgcagatggc cggggccggg ggtcgacgtg ccccgcgctc cgcgccattc cgccggcagc accgtggagc cgcanccgcg ggtcagaggc agcggcccgc gccgccccct tgctgcctcg tggtccgggc ctggggancc tgcgccgtgg agagccgcgc cgcccttcgc cgcccgggag gctgccgctg gctccgcctg gaccccctgg cctgcaggag agagctcgtt 98677.doc -191 - 200533758 ctgccgccgc agcaataaag ctcctttgcc gcgaaaa &lt; 210 &gt; 246 &lt; 211> 522 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 36929_at HG-U95Av2 &lt; 220 &gt; &lt; 221〉 mi sc-feature &lt; 222 &gt; 106, 109, 165..235, 239, 243, 246..251, 323 &lt; 223 &gt; n is a, g, c or t &lt; 400> 246 gtgcccggat ccagagtgtg aagacagagg cagaggagct gtttggggag accatggaga tgatggacag gatgaaagac atggagttgg agctgctgcg gggcanccna ggccatcatg ctgcgctcag cggacctgac aggactggag aagcgtgtgg agcannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngccng ttnccnnnnn natctgccgc ctttgctttt ggttgggggc agattgggtt ggaatgcttt ccatctccag gagactttca tgnagcctaa agtacagcct ggaccacccc tggtgtgtag ctagtaagat taccctgagc tgcagctgag cctgagccaa tgggacagtt acacttgaca gacaaagatg gtggagattg gcatgccatt gaaactaaga gctctcaagt caaggaagct gggctgggca gtatcccccg cctttagttc tccactgggg ag 397

60 120 180 240 300 360 420 480 98677.doc -192- 522 200533758 &lt;210&gt; 247 &lt;211〉 358 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 36965_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （97)..(119) &lt;223&gt; n 為 a，g，c 或 t60 120 180 240 300 360 420 480 98677.doc -192- 522 200533758 &lt; 210 &gt; 247 &lt; 211〉 358 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 36965_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (97) .. (119) &lt; 223 &gt; n is a, g, c or t

&lt;400〉 247 aatgcttgcc gctttagagg tggatggtgc tcataaaagg ccccagtcgg gggtatttaa aaaggactga acagaaatcc ttagctagta gaatggnnnn nnnnnnnnnn nnnnnnnnnt gtattgtgta ctggctataa gatgtagaca cctttcagta agccaatcat ttgtaaccat tctagcagtg tcatattagg ttaataaggc tgctgtgttt taaagggcat ttttatttgg gttttggtga aattctttaa tttgttgatt atattcacat aaaatcagca ttcattgaca 鲁 catagctcta atgacatatg tatgaaaaac catacactgg atgacctagt cgattatt &lt;210〉 248 &lt;211〉 456 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 37015—at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature 60 120 180 240 300 358 986'Tdoc -193- 200533758 &lt;222〉 （29)..(29) &lt;223〉η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc—feature &lt;222&gt; (68)..(68) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉&Lt; 400> 247 aatgcttgcc gctttagagg tggatggtgc tcataaaagg ccccagtcgg gggtatttaa aaaggactga acagaaatcc ttagctagta gaatggnnnn nnnnnnnnnn nnnnnnnnnt gtattgtgta ctggctataa gatgtagaca cctttcagta agccaatcat ttgtaaccat tctagcagtg tcatattagg ttaataaggc tgctgtgttt taaagggcat ttttatttgg gttttggtga aattctttaa tttgttgatt atattcacat aaaatcagca ttcattgaca Lu catagctcta atgacatatg tatgaaaaac catacactgg atgacctagt cgattatt &lt; 210> 248 &lt; 211 〉 456 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 37015-at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc-feature 60 120 180 240 300 358 986'Tdoc -193- 200533758 &lt; 222〉 (29) .. (29) &223; 223> η is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222 &gt; (68) .. (68) &lt; 223 &gt; n is a, g, c or t &lt; 220>

&lt;221&gt; misc一feature &lt;222&gt; (103)..(103) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （129)..(129) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 248 gtgaaaatct ctcagaagaa ctcataaang aaaatacaag agtggagaga agctcttcaa tagctaangc atctccttac agtcactaat atagtagatt ttnaaagaca aaatttttct tttcttgant ttttttaaac ataagctaaa tcatattagt attaatacta cccatagaaa acttgacatg tagcttcttc tgaaagaatt atttgccttc tgaaatgtga cccccaagtc ctatcctaaa taaaaaaaga caaattcgga tgtatgatct ctctagcttt gtcatagtta tgtgattttc ctttgtagct acttttgcag gataataatt ttatagaaaa ggaacagttg catttagctt ctttccctta gtgactcttg aagtacttaa catacacgtt aactgcagag taaattgctc tgttcccagt agttataaag tccttg 98677.doc -194- 200533758 &lt;210〉 249 &lt;211〉 509 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 37027—at HG-U95Av2 &lt;220〉 &lt;221&gt; &lt;222〉 &lt;223〉&lt; 221 &gt; misc-feature &lt; 222 &gt; (103) .. (103) &lt; 223 &gt; n is a, g, c or t &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222> (129) .. (129) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 248 gtgaaaatct ctcagaagaa ctcataaang aaaatacaag agtggagaga agctcttcaa tagctaangc atctccttac agtcactaat atagtagatt ttnaaagaca aaatttttct tttcttgant ttttttaaac ataagctaaa tcatattagt attaatacta cccatagaaa acttgacatg tagcttcttc tgaaagaatt atttgccttc tgaaatgtga cccccaagtc ctatcctaaa taaaaaaaga caaattcgga tgtatgatct ctctagcttt gtcatagtta tgtgattttc ctttgtagct acttttgcag gataataatt ttatagaaaa ggaacagttg catttagctt ctttccctta gtgactcttg aagtacttaa catacacgtt aactgcagag taaattgctc tgttcccagt agttataaag tccttg 98677.doc -194- 200533758 &lt; 210> 249 &lt; 211> 509 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 37027-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; &lt; 222〉 &lt; 223〉

misc_feature 26..53, 134..159, 322..348, 420, 441..478 η 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 480, 481， 483 &lt;223&gt; n 為 a，g, c 或 t &lt;400〉 249 60 120 180 240 300 360 420 gttgcagacg gaggtcaggt cttccnnnnn nnnnnnnnnn nnnnnnnnnn nnnagcaaac gcccacagat ggcccagagg tggtggtagt cagggtgtgt gggtgttttt agggttctttmisc_feature 26..53, 134..159, 322..348, 420, 441..478 η is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 480, 481, 483 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 249 60 120 180 240 300 300 360 420 gttgcagacg gaggtcaggt cttccnnnnn nnnnnnnnnn nnnnnnnnnn nnnagcaaac gcccacagat ggcccagagg tggtggtagt cagggtgtgt gggtcttttttt

agtgttgttt cttnnnnnnn nnnnnnnnnn nnnnnnnnng tttggtgctg acggtgagag gaaattagaa tctgtttgca aattgtccaa cccaccccct caacatgagg ggcttccatt ttctgtgttt tgtaagggaa ctgtttcctt catgccgcca tgttcctgat attagttctg atttcttttt aacaaatgtt annnnnnnnn nnnnnnnnnn nnnnnnnnta atggccaatt aactgagaat gtaagaaaat tgatgctgta caaggcaaat aaagctgttt attaaccttn aaaaaaaaaa aaaaaaaaaa nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnan 98677.doc -195 - 480 200533758 ncngccatgt tcctgatatt agttctgat 509 &lt;210&gt; 250 &lt;211〉 404 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 37168_at HG-U95Av2 &lt;400&gt; 250agtgttgttt cttnnnnnnn nnnnnnnnnn nnnnnnnnng tttggtgctg acggtgagag gaaattagaa tctgtttgca aattgtccaa cccaccccct caacatgagg ggcttccatt ttctgtgttt tgtaagggaa ctgtttcctt catgccgcca tgttcctgat attagttctg atttcttttt aacaaatgtt annnnnnnnn nnnnnnnnnn nnnnnnnnta atggccaatt aactgagaat gtaagaaaat tgatgctgta caaggcaaat aaagctgttt attaaccttn aaaaaaaaaa aaaaaaaaaa nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnan 98677.doc -195 - 480 200533758 ncngccatgt tcctgatatt agttctgat 509 &lt; 210 &gt; 250 &lt; 211〉 404 &lt; 212〉 DNA &lt; 213〉 human &lt; 220〉 &lt; 223 &gt; Probe 37168_at HG-U95Av2 &lt; 400 &gt; 250

cagttgctca tttttatggg attgcttagc tgggctgtaa agatgaaggc atcaaataaa 60 ctcaaagtat ttttaaattt ttttgataat agagaaactt cgctaaccaa ctgttctttc 120 ttgagtgtat agccccatct tgtggtaact tgctgcttct gcacttcata tccatatttc 180 ctattgttca ctttattctg tagagcagcc tgccaagaat tttatttctg ctgttttttt 240 tgctgctaaa gaaaggaact aagtcaggat gttaacagaa aagtccacat aaccctagaa 300 ttcttagtca aggaataatt caagtcagcc tagagaccat gttgactttc ctcatgtgtt 360 tccttatgac tcagtaagtt ggcaaggtcc tgactttagt ctta 404cagttgctca tttttatggg attgcttagc tgggctgtaa agatgaaggc atcaaataaa 60 ctcaaagtat ttttaaattt ttttgataat agagaaactt cgctaaccaa ctgttctttc 120 ttgagtgtat agccccatct tgtggtaact tgctgcttct gcacttcata tccatatttc 180 ctattgttca ctttattctg tagagcagcc tgccaagaat tttatttctg ctgttttttt 240 tgctgctaaa gaaaggaact aagtcaggat gttaacagaa aagtccacat aaccctagaa 300 ttcttagtca aggaataatt caagtcagcc tagagaccat gttgactttc ctcatgtgtt 360 tccttatgac tcagtaagtt ggcaaggtcc tgactttagt ctta 404

&lt;210〉 251 &lt;211〉 452 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 37185_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （94)..(113) 98677.doc -196- 200533758 &lt;223&gt; η 為 a，g，c 或 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （89)..(89) &lt;223&gt; η 為 a，g，c 或 t&lt; 210〉 251 &lt; 211〉 452 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 37185_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> (94 ): (113) 98677.doc -196- 200533758 &lt; 223 &gt; η is a, g, c or &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (89) .. (89) &lt; 223 &gt; η is a, g, c or t

&lt;400〉 251 ctcaccctaa aactaagcgt gctgcttctg caaaagattt ttgtagatga gctgtgtgcc 60 tcagaattgc tatttcaaat tgccaaaant ttannnnnnn nnnnnnnnnn nnnctgctct 120 tctgaacaac ttctgctacc cactaaataa aaacacagaa ataattagac aattgtctat 180 tataacatga caaccctatt aatcatttgg tcttctaaaa tgggatcatg cccatttaga 240 ttttccttac tatcagttta tttttataac attaactttt actttgttat ttattatttt 300 atataatggt gagtttttaa attattgctc actgcctatt taatgtagct aataaagtta 360 tagaagcaga tgatctgtta atttcctatc taataaatgc ctttaattgt tctcataatg 420 aagaataagt aggtatccct ccatgccctt ct 452 &lt;210&gt; 252 &lt;211&gt; 444 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37187^at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 36， 55, 59, 67, 78， 117， 137, 318, 331.,350 98677.doc -197- 60 200533758 &lt;223&gt; η 為 a，g，c 或 t &lt;400&gt; 252&Lt; 400> 251 ctcaccctaa aactaagcgt gctgcttctg caaaagattt ttgtagatga gctgtgtgcc 60 tcagaattgc tatttcaaat tgccaaaant ttannnnnnn nnnnnnnnnn nnnctgctct 120 tctgaacaac ttctgctacc cactaaataa aaacacagaa ataattagac aattgtctat 180 tataacatga caaccctatt aatcatttgg tcttctaaaa tgggatcatg cccatttaga 240 ttttccttac tatcagttta tttttataac attaactttt actttgttat ttattatttt 300 atataatggt gagtttttaa attattgctc actgcctatt taatgtagct aataaagtta 360 tagaagcaga tgatctgtta atttcctatc taataaatgc ctttaattgt tctcataatg 420 aagaataagt aggtatccct ccatgccctt ct 452 &lt; 210 &gt; 252 &lt; 211 &gt; 444 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 37187 ^ at HG-U95> 221 &gt; misc_feature &lt; 222〉 36, 55, 59, 67, 78, 117, 137, 318, 331., 350 98677.doc -197- 60 200533758 &lt; 223 &gt; η is a, g, c or t &lt; 400 &gt; 252

120 180 24〇 300 360 420 444 cgcctaatgt gtttgagcat cacttaggag aagtcntcta tttatttatt tattnattna tttgttngtt ttagaagntt ctatgttaat attttatgtg taaaataagg ttatgantga atctacttgc acactcnccc attatattta ttgtttattt taggtcaaac ccaagttagt tcaatcctga ttcatattta atttgaagat agaaggtttg cagatattct ctagtcattt gttaatattt cttcgtgatg acatatcaca tgtcagccac tgtgatagag gctgaggaat ccaagaaaat ggccagtnag atcaatgtga nnnnnnnnnn nnnnnnnnnn gtctattttg taactgtaaa gatgaatgtc agttgttatt tattgaaatg atttcacagt gtgtggtcaa catttctcat gttgaagctt taag &lt;210〉 253 &lt;211&gt; 572 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37218一at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （54)..(54) &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (68)..(68) 98677.doc -198- 200533758 &lt;223〉η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (80)..(80) &lt;223&gt; n 為 a，g，c 或 t24〇300 120 180 360 420 444 cgcctaatgt gtttgagcat cacttaggag aagtcntcta tttatttatt tattnattna tttgttngtt ttagaagntt ctatgttaat attttatgtg taaaataagg ttatgantga atctacttgc acactcnccc attatattta ttgtttattt taggtcaaac ccaagttagt tcaatcctga atttgaagat ttcatattta gatgaatgtc agttgttatt tattgaaatg agaaggtttg cagatattct ctagtcattt gttaatattt cttcgtgatg acatatcaca tgtcagccac tgtgatagag gctgaggaat ccaagaaaat ggccagtnag atcaatgtga nnnnnnnnnn nnnnnnnnnn gtctattttg taactgtaaa atttcacagt gtgtggtcaa catttctcat gttgaagctt taag &lt; 210〉 253 &lt; 211 &gt; 572 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 37218-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 (54) .. (54) &lt; 223> n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (68) .. (68) 98677.doc -198- 200533758 &lt; 223> η is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (80) .. (80) &lt; 223 &gt; n is a, g, c or t

&lt;400&gt; 253 gtgtaccaga tttcagaact tatatttcca cctcttccaa tgtggcaccc tttngcccag 60 aaaaaagncc aggaatgtan tcgagggaat ggccatcaga atcactatcc tcctcctgtt 120 ccatttggtt atccaaatca gggaagaaaa aataaaccat atcgcccaat tccagtgaca 180 tgggtacctc ctcctggaat gcattgtgac cggaatcact ggattaatcc tcacatgtta 240 gcacctcact aacttcgttt ttgattgtgt tggtgtcatg ttgagaaaaa ggtagaataa 300 accttactac acattaaaag ttaaaagttc ttactaatag tagtgaagtt agatgggcca 360 aaccatcaaa cttattttta tagaagttat tgagaataat ctttcttaaa aaatatatgc 420 actttagata ttgatatagt ttgagaaatt ttattaaagt tagtcaagtg ccgaagtttt 480 taatattgga cttgagtatt tatatattgt gcatcaactc tgttggatac gagaacactg 540 tagaagtgga cgatttgttc tagcaccttt ga 572 &lt;210&gt; 254 &lt;211&gt; 503 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 37221 at HG-U95Av2 98677.doc -199- 200533758 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 315..347, 371..374, 377, 378, 443, 448..450 &lt;223〉η 為 a, g，c 或 t &lt;400〉 254 tttatggtcc cacttgtata tgaaaatgtg gttagaatgt taattggata atgtatatat aagaagttaa agtatgtaaa gtataacttc agccacattt ttagaacact gtttaacatt tttgcaaaac cttcttgtag gaaaagagag ctctctacat gaagatgact tgttttatat ttcagatttt attttaaaag ccatgtctgt taaacaagaa aaaacacaaa agaactccag attcctggtt catcattctg tattcttact cactttttca agttatctat tttgttgcat aaactaattg ttaannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnaga actttgacca aggctataaa nnnnacnnac attattttca gtattgttgg ttatatttaa attttcctta caataaagca cacttttata atnaaaannn gaattattgt ttttcatact tttttgcttg tttcttaaag ttttctgacg tgc &lt;210&gt; 255 &lt;211〉 365 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 37241一at HG-U95Av2 &lt;220&gt; &lt;221〉mi sc一feature &lt;222〉 （219)..(233) 60 120 180 240 300 360 420 480 503 98677.doc -200 - 60 200533758 &lt;223&gt; η 為 a，g，c 或 t &lt;400&gt; 255&Lt; 400 &gt; 253 gtgtaccaga tttcagaact tatatttcca cctcttccaa tgtggcaccc tttngcccag 60 aaaaaagncc aggaatgtan tcgagggaat ggccatcaga atcactatcc tcctcctgtt 120 ccatttggtt atccaaatca gggaagaaaa aataaaccat atcgcccaat tccagtgaca 180 tgggtacctc ctcctggaat gcattgtgac cggaatcact ggattaatcc tcacatgtta 240 gcacctcact aacttcgttt ttgattgtgt tggtgtcatg ttgagaaaaa ggtagaataa 300 accttactac acattaaaag ttaaaagttc ttactaatag tagtgaagtt agatgggcca 360 aaccatcaaa cttattttta tagaagttat tgagaataat ctttcttaaa aaatatatgc 420 actttagata ttgatatagt ttgagaaatt ttattaaagt tagtcaagtg ccgaagtttt 480 taatattgga cttgagtatt tatatattgt gcatcaactc tgttggatac gagaacactg 540 tagaagtgga cgatttgttc tagcaccttt ga 572 &lt; 210 &gt; 254 &lt; 211 &gt; 503 &lt; 212 &gt; DNA &lt; 213> human &lt; 220> &lt; 223 &gt; Probe 37221 at HG-U95Av2 98677.doc -199- 200533758 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; 315..347, 371..374, 377, 378, 443, 448..450 &lt; 223 〉 Η is a, g, c or t &lt; 400〉 254 tttatggtcc cacttgtata tgaa aatgtg gttagaatgt taattggata atgtatatat aagaagttaa agtatgtaaa gtataacttc agccacattt ttagaacact gtttaacatt tttgcaaaac cttcttgtag gaaaagagag ctctctacat gaagatgact tgttttatat ttcagatttt attttaaaag ccatgtctgt taaacaagaa aaaacacaaa agaactccag attcctggtt catcattctg tattcttact cactttttca agttatctat tttgttgcat aaactaattg ttaannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnaga actttgacca aggctataaa nnnnacnnac attattttca gtattgttgg ttatatttaa attttcctta caataaagca cacttttata atnaaaannn gaattattgt ttttcatact tttttgcttg tttcttaaag ttttctgacg tgc &lt; 210 &gt; 255 &lt; 211〉 365 &lt; 212 &gt; DNA &lt; 213〉 human &lt; 220 &gt; &lt; 223〉 Probe 37241-at HG-U95Av2 &lt; 220 &gt; &lt; 221〉 mi sc-feature &lt; 222〉 (219) .. (233) 60 120 180 240 300 360 420 480 503 98677.doc -200-60 200533758 &lt; 223 &gt; η is a, g, c or t &lt; 400 &gt; 255

120 180 240 300 360 365 catgacatct ggaacacaga aagccctcaa tacattgaag ctcttaggat tttcacgatg ttcctgtctg ctcaatgcat gctttcttta ttgttctgac agttgtgtgg taacaagcta atatgcttcc agttgacttc cagtctaccc tggtgttaga aaccgtttca tctcttattg taaatttgag tgcttgttgt tttttatatt tgtgatgann nnnnnnnnnn nnnttgacaa ttgttagagg tttgactttt aaataattac ttattttttc tgattgtggt tcagtttaac tgaagaatat cctgagattg taagaaaagc attttttaaa aggtatcact tgtgatcatt tatct &lt;210&gt; 256 &lt;211&gt; 566 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; • &lt;223&gt; Probe 37255_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 26, 37..61, 153, 438..477, 527, 528 &lt;223&gt; n 為 a, g，c 或 t &lt;400&gt; 256 60 gettggacag ccagtgccct cgtggnttcg ggaagannnn nnnnnnnnnn nnnnnnnnnn ntgtcccagc ctcccatacc agcaaaatgc cccctgcttc cctaagggtc aggtccagag 98677 doc -201 - 120 180 180120 180 240 300 360 365 catgacatct ggaacacaga aagccctcaa tacattgaag ctcttaggat tttcacgatg ttcctgtctg ctcaatgcat gctttcttta ttgttctgac agttgtgtgg taacaagcta atatgcttcc agttgacttc cagtctaccc tggtgttaga aaccgtttca tctcttattg taaatttgag tgcttgttgt tttttatatt tgtgatgann nnnnnnnnnn nnnttgacaa ttgttagagg tttgactttt aaataattac ttattttttc tgattgtggt tcagtttaac tgaagaatat cctgagattg taagaaaagc attttttaaa aggtatcact tgtgatcatt tatct &lt; 210 &gt; 256 &lt; 211 &gt; 566 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; • &lt; 223 &gt; Probe 37255_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 26, 37..61, 153, 438 .. 477, 527, 528 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 256 60 gettggacag ccagtgccct cgtggnttcg ggaagannnn nnnnnnnnnnnn nnnnnnnnnn ntgtcccagc ctcccatacc agcaaaatgc 180cc ccggtccc ccggtctgcc

200533758 cagggcccac aagggggatt agagtggcct ggnccctccc cctctacctc agtagccccc aggcctgaga tggctgagaa gggaagggta tccttttccc acagttctgg gacaaataaa ggggcttcct ttggtacccc acataatagt gctaggtacc tttgacccat catcttggga ggtggggagg aatgagaggg tccaggcagg gtgtagggga atgtattagt ccaatgagat ttccctcttc atccgcagca gtgtatctat tctatacctg gctatgggag agaccccttg catgggaggg accccttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnccc ggcctcccta atgtcattca cattgaatgg ggatgaggtc ggacagnngc tcatagagcc gagtatgagc cctagctgtg ggctag &lt;210&gt; 257 &lt;211&gt; 526 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37286HG-U95Av2 # &lt;400&gt; 257 cacctttttt gctgtgaaac tgaaatagtg aacttttcta cgtattgaca gcagattttt cgatgaaatc ttcagagctt tgcctatggg gcacagtagg cctagtaacc tggcatgttt gatatatgta ggtaaagcat aatttaaagt aatcccaggt aaagatggcc ctaaatactt tcatgtctct atattcattt ttcacagatc cacctgtctc ttgaaaatat aaaaagacaa aacaggtttg ccttggcatc agagagcaca aagattaaaa gttactttaa atttgccaat attttgggag aacaataaaa ctacattttt tcctcttcca tactggtaga tgcgaaattt 240 300 360 420 480 540 566 60 120 180 240 300 98677.doc -202 - 360 200533758 atctgtgcat gaaagggtca cttctgtaat agtgcaacag atttggtatt aaaaattaaa tgtggtttta aaagttcctc tctcttttgt aatttatgtt cccaattgag tgtgaatgtc caagtaatgg tgtatgtaat ggtacaggca aatgtgactg gatttc &lt;210〉 258 &lt;211&gt; 143 &lt;212〉 DNA &lt;213&gt;人類 • &lt;220&gt; &lt;223&gt; Probe 37287_at HG-U95Av2 &lt;400〉 258 tgtaaatggt tctcggagct tctttgggtt aaagggtcta atgccaggaa cagcatacaa agttcgagtt ggtgctgtgg gggactctgg ttttgtgagt tcagaggatg tgtttgagac aggcccagcg atggcaagcc ggc &lt;210〉 259 &lt;211&gt; 371 φ &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 37288_g_at HG-U95Av2 &lt;220〉 &lt;221〉mi sc—feature &lt;222〉 （113)..(187) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 259 98677.doc 203 - 200533758200533758 cagggcccac aagggggatt agagtggcct ggnccctccc cctctacctc agtagccccc aggcctgaga tggctgagaa gggaagggta tccttttccc acagttctgg gacaaataaa ggggcttcct ttggtacccc acataatagt gctaggtacc tttgacccat catcttggga ggtggggagg aatgagaggg tccaggcagg gtgtagggga atgtattagt ccaatgagat ttccctcttc atccgcagca gtgtatctat tctatacctg gctatgggag agaccccttg catgggaggg accccttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnccc ggcctcccta atgtcattca cattgaatgg ggatgaggtc ggacagnngc tcatagagcc gagtatgagc cctagctgtg ggctag &lt; 210 &gt; 257 &lt; 211 &gt; 526 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 37286HG-U95Av2 # &lt; 400 &gt; 257 cacctttttt gctgtgaaac tgaaatagtg aacttttcta cgtattgaca gcagattttt cgatgaaatc ttcagagctt tgcctatggg gcacagtagg cctagtaacc tggcatgttt gatatatgta ggtaaagcat aatttaaagt aatcccaggt aaagatggcc ctaaatactt tcatgtctct atattcattt ttcacagatc cacctgtctc ttgaaaatat aaaaagacaa aacaggtttg ccttggcatc agagagcaca aagattaaaa gttactttaa atttgccaat attttgggag aacaataacc ctcttcctt a tactggtaga tgcgaaattt 240 300 360 420 480 540 566 60 120 180 240 300 98677.doc -202 - 360 200533758 atctgtgcat gaaagggtca cttctgtaat agtgcaacag atttggtatt aaaaattaaa tgtggtttta aaagttcctc tctcttttgt aatttatgtt cccaattgag tgtgaatgtc caagtaatgg tgtatgtaat ggtacaggca aatgtgactg gatttc &lt; 210> 258 &lt; 211 &gt; 143 &lt; 212> DNA &lt; 213 &gt; human • &lt; 220 &gt; &lt; 223 &gt; Probe 37287_at HG-U95Av2 &lt; 400> 258 tgtaaatggt tctcggagct tctttgggtt aaagggtcta atgccagggttcctggtggtggtggtggtggtggtggtgt ; 211 &gt; 371 φ &lt; 212 &gt; DNA &lt; 213> Human &lt; 220 &gt; &lt; 223 &gt; Probe 37288_g_at HG-U95Av2 &lt; 220> &lt; 221〉 mi sc-feature &lt; 222〉 (113) .. 187) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 259 98677.doc 203-200533758

ctcagggctg gttcattggt ctgatgtgtg ctgttgctct ccttatctta attttgctga 60 ttgtttgctt catcagaaga aacaagggtg gtaaatatcc agttaaagaa aannnnnnnn 120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 180 nnnnnnnaga agaccacaag cctttgaaaa aaggaagtcg aactccttca gacaggactg 240 tgaaaaaaga agatagtgac gacagcctag ttgactatgg agaaggggtt aatggccagt 300 tcaa.tgagga tggctccttt attggacaat acagtggtaa gaaagagaaa gagccggctg 360 aaggaaacga a 371 &lt;210〉 260 &lt;211〉 387 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 37352^at HG-U95Av2 &lt;400〉 260 gatgccaaga cttggcctgc agaatgtcag gaatgtgaat taaaagctgc tgtttccaga 60 cgctttttat tctgagcacc ttcactacct tgtatccagt tcatctggga actccttttt 120 gcattttaga aaatggaaag aggcaggaaa ttatgataaa ctcatgttta acagaaagag 180 tttcactgac taaatgtatg taattatatt ttgttgttgt agaagaaata aatagcaaat 240 ttgtggtatt ctttttttta aacctgctct cattcctatt aacactaaga tcttagattt 300 ttatagtgat aaatgggttg acatcattgt catttgtaat tgtaaagcct caaaagacaa 360 ctgttcctac tatgtaatta tagacag 387 9S677.doc -204- 200533758 &lt;210〉 261 &lt;211〉 156 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 37353—g—at HG-U95Av2 &lt;400〉 261 aagcaagcat ggtgagaagg ctcctatgac ttctagaagt acatctactt ggagaataccctcagggctg gttcattggt ctgatgtgtg ctgttgctct ccttatctta attttgctga 60 ttgtttgctt catcagaaga aacaagggtg gtaaatatcc agttaaagaa aannnnnnnn 120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 180 nnnnnnnaga agaccacaag cctttgaaaa aaggaagtcg aactccttca gacaggactg 240 tgaaaaaaga agatagtgac gacagcctag ttgactatgg agaaggggtt aatggccagt 300 tcaa.tgagga tggctccttt attggacaat acagtggtaa gaaagagaaa gagccggctg 360 aaggaaacga a 371 &lt; 210 > 260 &lt; 211> 387 &lt; 212> DNA &lt; 213> human &lt; 220> &lt; 223 &gt; Probe 37352 ^ at HG-U95Av2 &lt; 400> 260 gatgccaaga cttggcctgc agaatgtcag gaatgtgaat taaaagctgc tgtttcccc tctgattctgacc tctgacc 120 gcattttaga aaatggaaag aggcaggaaa ttatgataaa ctcatgttta acagaaagag 180 tttcactgac taaatgtatg taattatatt ttgttgttgt agaagaaata aatagcaaat 240 ttgtggtatt ctttttttta aacctgctct cattcctatt aacactaaga tcttagattt 300 ttatagtgat aaatgggttg acatcattgt catttgtaat tgtaaagcct caaaagacaa 360 ctgttcctac tatgtaat ta tagacag 387 9S677.doc -204- 200533758 &lt; 210〉 261 &lt; 211〉 156 &lt; 212〉 DNA &lt; 213〉 Human &lt; 220 &gt; &lt; 223〉 Probe 37353-g-at HG-U95Av2 &lt; 400 〉 261 aagcaagcat ggtgagaagg ctcctatgac ttctagaagt acatctactt ggagaatacc

60 120 156 cagcaggaag agacgtttca gcagtagtga cttttcagac ctgagtaatg gagaagagct tcaggaaacc tgcagctcat ccctaagaag agggtc &lt;210&gt; 262 &lt;211&gt; 555 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37354一at HG-U95Av2 φ &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 205, 208, 212, 216, 253, 270, 273, 282, 320, 326, 490..508 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 262 60 120 ttctactttg gaaaaacaca gtgggaaaag aagaaaaaag agaaggcata gatctaaagt aaatggtctc caaagaggga gaaagaaaga cagacctaga aaacatttaa ctctgaataa caaagtccaa aagaaaagat ggcaacaaag aggaagaaaa gccaacacta gacctttgaa 98&lt;v7.doc -205 - 180 20053375860 120 156 cagcaggaag agacgtttca gcagtagtga cttttcagac ctgagtaatg gagaagagct tcaggaaacc tgcagctcat ccctaagaag agggtc &lt; 210 &gt; 262 &lt; 211 &gt; 555 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 354 &lt;220; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 205, 208, 212, 216, 253, 270, 273, 282, 320, 326, 490..508 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 262 60 120 ttctactttg gaaaaacaca gtgggaaaag aagaaaaaag agaaggcata gatctaaagt aaatggtctc caaagaggga gaaagaaaga cagacctaga aaacatttaa ctctgaataa 2005 -7ggagaac7ggagaacgcgagac7ggaacac-ggagaacac-gaga

aagaagaaga aaaagaggtc caagnatncc cnaagntgaa aatattaatt ttaaacaatc 240 tgaacttcct gtnacctgtg gtgaggtgan ggncactcta tntaaggagc gattcaaaca 300 aggaacctca aagaagtgtn tacagngtga ggataaaaag tggttcactc ccagggaatt 360 tgaaattgaa ggagaccgcg gagcatccaa gaactggaag ctaagtatac gctgcggtgg 420 atataccctg aaagtcctga tggagaacaa atttctgcca gaaccaccaa gcacaagaaa 480 aaaggtgatn nnnnnnnnnn nnnnnnnnaa tgtctcgtct attatgttgt tgattttcta 540 tctctgtgga cttac 555 &lt;210〉 263 &lt;211&gt; 166 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37377—i—at HG_U95Av2 &lt;400&gt; 263 ctctgtgcag tcactggagg ttgaagccaa gtggggtgct gggaggaggg agagggaggt 60aagaagaaga aaaagaggtc caagnatncc cnaagntgaa aatattaatt ttaaacaatc 240 tgaacttcct gtnacctgtg gtgaggtgan ggncactcta tntaaggagc gattcaaaca 300 aggaacctca aagaagtgtn tacagngtga ggataaaaag tggttcactc ccagggaatt 360 tgaaattgaa ggagaccgcg gagcatccaa gaactggaag ctaagtatac gctgcggtgg 420 atataccctg aaagtcctga tggagaacaa atttctgcca gaaccaccaa gcacaagaaa 480 aaaggtgatn nnnnnnnnnn nnnnnnnnaa tgtctcgtct attatgttgt tgattttcta 540 tctctgtgga cttac 555 &lt; 210> 263 &lt; 211 &gt; 166 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 37377-i-at HG_U95Av2 &lt; 400 &gt; 263 ctctgtgcag tcactggagg ttgaagccaa gtggggtgct gggaggaggg agagggaggt

cactggaaag gggagagcct gctggcaccc accgtggagg aggaaggcaa gagggggtgg 120 aggggtgtgg cagtggtttt ggcaaacgct aaagagccct tgcctc 166 &lt;210&gt; 264 &lt;211&gt; 208 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37383_f_at HG-U95Av2 98677.doc -206 - 200533758 &lt;220&gt; &lt;221&gt; mi sc一feature &lt;222〉 46, 63, 105, 106, 115, 127, 132, 133, 146, 154, 155, 165 &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 177， 183 &lt;223〉n 為 a，g，c 或 tcactggaaag gggagagcct gctggcaccc accgtggagg aggaaggcaa gagggggtgg 120 aggggtgtgg cagtggtttt ggcaaacgct aaagagccct 166 &lt; 210 &gt; 264 &lt; 211 &gt; 208 &lt; 212> DNA &lt; 223 &gt; 213 &gt; 206-200533758 &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222〉 46, 63, 105, 106, 115, 127, 132, 133, 146, 154, 155, 165 &lt; 223 &gt; η is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 177, 183 &lt; 223〉 n is a, g, c or t

&lt;400〉 264 cctttgtgac gtncctgtta ccctgtnccc ggnctggatg ttcaagagcc gcataatgtg annctgacct tctccatctc tctggcatct aggaggtgga gtgttncctc tgtctcaa ctttctgcaa gagacagccc cccnntcatc aggcanctga acccnngtgt tttcntgttc atgtgtctgc ccacngtgac cagagangtg &lt;210&gt; 265 &lt;211&gt; 224 &lt;212&gt; DNA φ &lt;2丨3&gt;人類 &lt;220〉 &lt;223〉 Probe 37388—at HG-U95Av2 &lt;400&gt; 265 ttgacaaatg actcttcagt tatgcatatc taaacacaca tatatgcctg cagggactgg ttctgactcc tatacacaaa agaactttga ttgaagattt cagggataca catcacagaa atgatgctga tatggatgag taagaaacac gatactaaag aagctagaag gagttagcaa agggcctaga gtat caaaccaggt aatatctata acagtatgaa 98677.doc -207 - 200533758 &lt;210&gt; 266 &lt;211〉 446 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 37393—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature • &lt;222&gt; 46, 57, 177..179, 187 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 266 tcccgatggc cagtttgctt tcctcattcc caacggggcc ttcgcncaca gcggccntgt 60 catccccgtc tacaccagca acagcggcac ctccgtgggc cccaacgcag tgtcaccttc 120 cagcggcccc tcgcttacgg cggactccat gtggaggccg tggcggaact gaggggnnnt 180 caggccnacc cctcctccta aactccccaa cccacctctc ttccctccgg actctaaaca 240 ^ ggaacttgaa tactgggaga gaagaggact tttttgatta agtggttact ttgtgttttt 300 ttaatttcta agaagttact ttttgtagag agagctgtat taagtgactg accatgcact 360 atatttgtat atattttata tgttcatatt ggattgcgcc tttgtattat aaaagctcag 420 atgacatttc gttttttaca cgagat 446 &lt;210〉 267 &lt;211〉 316 &lt;212&gt; DNA &lt;213&gt;人類 98677.doc 208 - 200533758 &lt;220〉 &lt;223&gt; Probe 37402.at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （90)..(90) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature φ &lt;222&gt; (95)..(95) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 267&Lt; 400> 264 cctttgtgac gtncctgtta ccctgtnccc ggnctggatg ttcaagagcc gcataatgtg annctgacct tctccatctc tctggcatct aggaggtgga gtgttncctc tgtctcaa ctttctgcaa gagacagccc cccnntcatc aggcanctga acccnngtgt tttcntgttc atgtgtctgc ccacngtgac cagagangtg &lt; 210 &gt; 265 &lt; 211 &gt; 224 &lt; 212 &gt; DNA φ &lt; 2 Shu 3 &gt; human &lt; 220> &lt; 223> Probe 37388-at HG-U95Av2 &lt; 400 &gt; 265 ttgacaaatg actcttcagt tatgcatatc taaacacaca tatatgcctg cagggactgg ttctgactcc tatacacaaa agaactttga ttgaagattt cagggataca catcacagaa atgatgctga tatggatgag taagaaacac gatactaaag aagctagaag gagttagcaa agggcctaga gtat caaaccaggt aatatctata acagtatgaa 98677.doc -207 - 200533758 &lt; 210 &gt; 266 &lt; 211〉 446 &lt; 212 &gt; DNA &lt; 213〉 human &lt; 220 &gt; &lt; 223 &gt; Probe 37393-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature • &lt; 222 &gt; 46, 57, 177..179, 187 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 266 tcccgatggc cagtttgctt tcctcattcc caacggggcc ttcgcncaca gcggccntgt 60 catccccgtc tacaccagca acagcggcac ctccgt gggc cccaacgcag tgtcaccttc 120 cagcggcccc tcgcttacgg cggactccat gtggaggccg tggcggaact gaggggnnnt 180 caggccnacc cctcctccta aactccccaa cccacctctc ttccctccgg actctaaaca 240 ^ ggaacttgaa tactgggaga gaagaggact tttttgatta agtggttact ttgtgttttt 300 ttaatttcta agaagttact ttttgtagag agagctgtat taagtgactg accatgcact 360 atatttgtat atattttata tgttcatatt ggattgcgcc tttgtattat aaaagctcag 420 atgacatttc gttttttaca cgagat 446 &lt; 210> 267 &lt; 211〉 316 &lt; 212 &gt; DNA &lt; 213 &gt; human 98677.doc 208-200533758 &lt; 220〉 &lt; 223 &gt; Probe 37402.at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 (90 ): (90) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature φ &lt; 222 &gt; (95) .. (95) &lt; 223 &gt; n is a, g , C or t &lt; 400 &gt; 267

60 120 180 240 300 316 aaaggtcacc tgcaagaacg ggcagggcaa ctgctacaag agcaactcca gcatgcacat cacagactgc cgcctgacaa acggctccan ggtancccca actgtgcata ccggaccagc ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt gatgcttctg tggaggactc tacctaaggt cagagcagcg agatacccca cctccctcaa cctcatcctc tccacagctg cctcttccct cttccttccc tgctgtgaaa gaagtaacta cagttagggc tcctat &lt;210&gt; 268 &lt;211&gt; 470 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37417_at HG-U95Av2 98677.doc -209 -60 120 180 240 300 316 aaaggtcacc tgcaagaacg ggcagggcaa ctgctacaag agcaactcca gcatgcacat cacagactgc cgcctgacaa acggctccan ggtancccca actgtgcata ccggaccagc ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt gatgcttctg tggaggactc tacctaaggt cagagcagcg agatacccca cctccctcaa cctcatcctc tccacagctg cctcttccct cttccttccc tgctgtgaaa gaagtaacta cagttagggc tcctat &lt; 210 &gt; 268 &lt; 211 &gt; 470 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 37417_at HG-U95Av2 98677.doc -209-

200533758 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （316)..(316) &lt;223&gt; η 為 a，g，c 或 t &lt;400&gt; 268 ccgctcttct tgaatcatgc tgggctgccc ctgctcagca ccccgcctgg tgtgggcctg gtctcagcag cggctgcggc tgtggcagcc tccatctcca gcaagtctcc tggcctctcc tcctcatcct cttcatcctc atcctcctcc tcctccactt gcagcgagac ggcagcacag acccctggag gtccaggggg gcccgaggca gggtccaaac ctgagtgagg gccagccatg cctcccctcc cattcctctg gtccctgcct tggtcccttg cctgggaaga gggcgaggag gccagtggtg gggacncaga gggtcctcag agcaggagtg acaagggagg aaagaccaaa aaaacaacca accaaaaaaa aaaaaaaaaa aggaaagaaa ctaaccaaca aaagagaaaa ccaaaaataa tcacaacaga aaccagctgc cccaaaggaa ccagaggtga &lt;210〉 269 φ &lt;211〉 334 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 37419_g—at HG-U95Av2 &lt;400〉 269 gagaaacgca tcaacccctg cagtgcggcc cccatgctgc ccagcccagg gaagccggcc agctacagcc cccatatggt cacaccccaa gggggcgcgg ggaccttacc gttgtcccaa gcttccagca gtctgagcac aacagttact accttatcct cagctgtggg gacgctccac 60 120 180 240 300 360 420 470 60 120 98o77.doc -210- 180 240 240200533758 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> (316) .. (316) .. (316) &lt; 223 &gt; η is a, g, c or t &lt; 400 &gt; 268 ccgctcttct tgaatcatgc tgggctgccc ctgctcagca ccccggggggtgggt tgtggcagcc tccatctcca gcaagtctcc tggcctctcc tcctcatcct cttcatcctc atcctcctcc tcctccactt gcagcgagac ggcagcacag acccctggag gtccaggggg gcccgaggca gggtccaaac ctgagtgagg gccagccatg cctcccctcc cattcctctg gtccctgcct tggtcccttg cctgggaaga gggcgaggag gccagtggtg gggacncaga gggtcctcag agcaggagtg acaagggagg aaagaccaaa aaaacaacca accaaaaaaa aaaaaaaaaa aggaaagaaa ctaaccaaca aaagagaaaa ccaaaaataa tcacaacaga aaccagctgc cccaaaggaa ccagaggtga &lt; 210> 269 φ &lt; 211> 334 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 37419_g-at HG-U95Av2 &lt; 400> 269 gagaaacgca tcaacccctg cagtgcggcc cccatgctgc ccagcccagg gaagccggcc agctacagcc cccatatggt cacaccccaa gggggcgcgg ggaccttacc gttgtcccaa gcttccagca gtctgagcac aacagttact accttatcct cagctgtggg gacgctccac 60 120 180 240 300 360 4 20 470 60 120 98o77.doc -210- 180 240 240

200533758 cccagccgga cagctggagg gggtgggggc gggggcgggg ctgcgccccc cctcaattcc atcccctctg tcactccccc acccccggcc accaccaaca gcacaaaccc cagccctcaa ggcagccact cggctatcgg cttgtcaggc ctga &lt;210&gt; 270 &lt;211&gt; 561 &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223〉 Probe 37420」_at HG-U95Av2 &lt;220〉 &lt;221&gt; miscjeature &lt;222〉 260, 265, 267, 268, 303..318, 417·.457' &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 270 cgcagatcct ccaaaggcac acgttgccca ccaccccatc tctgaccatg aggccaccct • gaggtgctgg gccctgggct tctaccctgc ggagatcacg ctgacctggc agcgggatgg ggaggaacag acccaggaca cagagcttgt ggagaccagg cctgcagggg atggaacctt ccagaagtgg gccgctgtgg tggtgccttc tggagaggaa cagagataca catgccatgt gcagcacgag gggctgcccn agccncnnat cctgagatgg gagcagtctc cccagcccac cannnnnnnn nnnnnnnntc gttgctggcc ttgttgtcct tggagctgtg gtcactggag ctgtggtcgc tgctgtgatg tggaggaaga agagctcaga tagaaacaga gggagcnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnggt gtctctcaca gctaataaag 300 334 60 120 180 240 300 360 420 98677.doc -211 - 480 540 200533758 tgtgagacag cttccttgtg tgggactgag aagcaagata tcaatgtagc agaattgcac ttgtgcctca cgaacataca t &lt;210&gt; 271 &lt;211&gt; 521 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37421_f—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 39, 299, 304, 306, 307, 342..357, 456..496 &lt;223&gt; n 為 a, g, c 或 t &lt;400〉 271 ccgcagatac ttggagaatg ggaaggagac gctacagcnc gcagatcctc caaaggcaca cgttgcccac caccccatct ctgaccatga ggccaccctg aggtgctggg ccctgggctt • ctaccctgcg gagatcacgc tgacctggca gcgggatggg gaggaacaga cccaggacac agagcttgtg gagaccaggc ctgcagggga tggaaccttc cagaagtggg ccgctgtggt ggtgccttct ggagaggaac agagatacac atgccatgtg cagcacgagg ggctgcccna gccncnnatc ctgagatggg agcagtctcc ccagcccacc annnnnnnnn nnnnnnntcg ttgctggcct tgttgtcctt ggagctgtgg tcactggagc tgtggtcgct gctgtgatgt ggaggaagaa gagctcagat agaaacagag ggagcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnggtg tctctcacag ctaataaagt g 561200533758 cccagccgga cagctggagg gggtgggggc gggggcgggg ctgcgccccc cctcaattcc atcccctctg tcactccccc acccccggcc accaccaaca gcacaaaccc cagccctcaa ggcagccact cggctatcgg cttgtcaggc ctga &lt; 210 &gt; 270 &lt; 211 &gt; 561 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223> Probe 37420 "_at HG -U95Av2 &lt; 220〉 &lt; 221 &gt; miscjeature &lt; 222〉 260, 265, 267, 268, 303..318, 417 · .457 '&lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 270 cgcagatcct ccaaaggcac acgttgccca ccaccccatc tctgaccatg aggccaccct • gaggtgctgg gccctgggct tctaccctgc ggagatcacg ctgacctggc agcgggatgg ggaggaacag acccaggaca cagagcttgt ggagaccagg cctgcagggg atggaacctt ccagaagtgg gccgctgtgg tggtgccttc tggagaggaa cagagataca catgccatgt gcagcacgag gggctgcccn agccncnnat cctgagatgg gagcagtctc cccagcccac cannnnnnnn nnnnnnnntc gttgctggcc ttgttgtcct tggagctgtg gtcactggag ctgtggtcgc tgctgtgatg tggaggaaga agagctcaga tagaaacaga gggagcnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnggt gtctctcaca gctaataaag 300 334 60 120 180 240 300 360 42 0 98677.doc -211-480 540 200533758 tgtgagacag cttccttgtg tgggactgag aagcaagata tcaatgtagc agaattgcac ttgtgcctca cgaacataca t &lt; 210 &gt; 271 &lt; 211 &gt; 521 &lt; 212 &gt; DNA &lt; 213 &gt; Probe> at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; 39, 299, 304, 306, 307, 342..357, 456..496 &lt; 223 &gt; n is a, g, c or t &lt; 400> 271 ccgcagatac ttggagaatg ggaaggagac gctacagcnc gcagatcctc caaaggcaca cgttgcccac caccccatct ctgaccatga ggccaccctg aggtgctggg ccctgggctt • ctaccctgcg gagatcacgc tgacctggca gcgggatggg gaggaacaga cccaggacac agagcttgtg gagaccaggc ctgcagggga tggaaccttc cagaagtggg ccgctgtggt ggtgccttct ggagaggaac agagatacac atgccatgtg cagcacgagg ggctgcccna gccncnnatc ctgagatggg agcagtctcc ccagcccacc annnnnnnnn nnnnnnntcg ttgctggcct tgttgtcctt ggagctgtgg tcactggagc tgtggtcgct gctgtgatgt ggaggaagaa gagctcagat agaaacagag ggagcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnggtg tctctcacag ctaataaagt g 561

60 120 180 240 300 360 420 480 98677.doc -212 - 521 200533758 &lt;210&gt; 272 &lt;211&gt; 359 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37423—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature • &lt;222〉 （227)..(227) &lt;223&gt; η 為 a，g，c 或 t &lt;400〉 272 60 120 180 240 300 359 ttcataaatg ttctatacag tggacagccc tccagaatgg tacttcagtg cctagtgtag taactgaaat cttcaatgac acattaacat cacaatggcg aatggtgact tttctttcac gatttcatta atttgaaagc acacaggaaa gttgctccat tgataacgtg tatggagact tcggttttag tcaattccat atctcaatct taatggtgat tcttctntgt tgaactgaag • tttgtgagag tagttttcct ttgctacttg aatagcaata aaagcgtgtt aactttttga ttgatgaaag aagtacaaaa agcctttagc cttgaggtgc cttctgaaat taaccaaat &lt;210〉 273 &lt;211&gt; 457 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 37452^at HG-U95Av2 98677.doc -213 - 200533758 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 44, 104, 131.· 150, 272..286 &lt;223&gt; n為a，g，c或 t &lt;400&gt; 273 tagagactca actatccaag tggtggagaa tggggagtcc tccnagggcc gattttccgt ccagatgttc cggtttgctg gaaactatga cctagtctac ctgnactgtg aagtctatct ctgtgacacc nnnnnnnnnn nnnnnnnnnn tacctgctct gggaccagat tccgaagtgg60 120 180 240 300 360 420 480 98677.doc -212-521 200533758 &lt; 210 &gt; 272 &lt; 211 &gt; 359 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 37423-at HG- U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature • &lt; 222〉 (227) .. (227) &lt; 223 &gt; η is a, g, c or t &lt; 400〉 272 60 120 180 240 300 359 ttcataaatg ttctatagg tggacagccc tccagaatgg tacttcagtg cctagtgtag taactgaaat cttcaatgac acattaacat cacaatggcg aatggtgact tttctttcac gatttcatta atttgaaagc acacaggaaa gttgctccat tgataacgtg tatggagact tcggttttag tcaattccat atctcaatct taatggtgat tcttctntgt tgaactgaag • tttgtgagag tagttttcct ttgctacttg aatagcaata aaagcgtgtt aactttttga ttgatgaaag aagtacaaaa agcctttagc cttgaggtgc cttctgaaat taaccaaat &lt; 210> 273 &lt; 211 &gt; 457 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 37452 ^ at HG-U95Av2 98677.doc -213-200533758 &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222> 44, 104, 131. · 150, 272..286 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 273 tagagactca actatccaag tggtggagaa tggggagtcc tccnagggcc gattttccgt ccagatgttc cggtttgctg gaaactatga cctagtctac ctgnactgtg aagtctatct ctgtgacacc nnnnnnnnnn nnnnnnnnnn tacctgctct gggaccagat tcc

60 120 180 240 300 360 420 457 gagtgtcata gatcaatccc gtgtcctgaa cttgggtccc atcacacgga aaggtgtcca ggccacagtc tcaagggctt ttagcagctt gnnnnnnnnn nnnnnntggc tgcctctgct tctctcggcc accttgaccc tgacttttca gtgactgaca gcggaaagcc ctgtgctcca tggctgccat ctcacctcct gctgggcagg gggcatgatg cgggccagtg ctccagccac agaaaagaaa gttcatgctt tgttcagcct gccttct &lt;210〉 274 φ &lt;211〉 577 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37459_at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature &lt;222〉 29·.63, 74·.76, 80..83, 86, 87， 105， 107..114， 116..119 &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; 98677.doc 200533758 &lt;221&gt; misc一feature &lt;222〉 123， 127， 131， 132， 134·.138, 140·.142, 285, 287, 289..291 &lt;223〉n 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc^feature &lt;222&gt; 293..296, 298, 301..303, 311, 497, 521, 528, 530, 532..535 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 537..539, 541..546 • &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 274 gagaccgggt gttcctccag atgccctcnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnntccactc ctcnnnttcn nnntanntat tgtatcccat gtaanannnn nnnnannnna aanaaanaaa nnannnnnan nntatagaag aaaatgacac accaaaaaat ccaaatgaaa aacataattg cttcaaaaca cttacacagt tggaaagtta tatgtaagtg aaaatttgga ccattgtgta caaataaaaa ctaagatgca tgtttaatac tccananann ngnnnngnaa60 120 180 240 300 360 420 457 gagtgtcata gatcaatccc gtgtcctgaa cttgggtccc atcacacgga aaggtgtcca ggccacagtc tcaagggctt ttagcagctt gnnnnnnnnn nnnnnntggc tgcctctgct tctctcggcc accttgaccc tgacttttca gtgactgaca gcggaaagcc ctgtgctcca tggctgccat ctcacctcct gctgggcagg gggcatgatg cgggccagtg ctccagccac agaaaagaaa gttcatgctt tgttcagcct gccttct &lt; 210> 274 φ &lt; 211> 577 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 37459_at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc-feature &lt; 222〉 29 · 63, 74 · .76, 80..83, 86, 87, 105, 107..114, 116..119 &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; 98677.doc 200533758 &lt; 221 &gt; misc-feature &lt; 222> 123, 127 , 131, 132, 134 · .138, 140 · .142, 285, 287, 289..291 &lt; 223〉 n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 293..296, 298, 301..303, 311, 497, 521, 528, 530, 532..535 &lt; 223〉 n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; 537..539, 541..546 • &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 274 gagaccgggt gttcctccag atgccctcnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnntccactc ctcnnnttcn nnntanntat tgtatcccat gtaanannnn nnnnannnna aanaaanaaa nnannnnnan nntatagaag aaaatgacac accaaaaaat ccaaatgaaa aacataattg cttcaaaaca cttacacagt tggaaagtta tatgtaagtg aaaatttgga ccattgtgta caaataaaaa ctaagatgca tgtttaatac tccananann ngnnnngnaa

nnncgaatga ntgggataga gttatgtatc aagtactgac acttggttgt acccactgga atcatattag ctgttttatg ttatatgctt ccacagtaac ctgcttattc agatcagtca aaatatatca gtatgaaaga tcatagctaa tgaaaggcac tcactcatat tgtttacttt aaaatattta taaatangcc ttaaagaaat acaaatgata ncaattanan annnnannna nnnnnntaat ttcctctgta tttgtgtaga tactttg &lt;210&gt; 275 60 120 180 240 300 360 420 480 540 98677.doc -215 - 577 200533758 &lt;211〉 477 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 3746l.at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （26)..(26) &lt;223〉n 為 a，g，c 或 tnnncgaatga ntgggataga gttatgtatc aagtactgac acttggttgt acccactgga atcatattag ctgttttatg ttatatgctt ccacagtaac ctgcttattc agatcagtca aaatatatca gtatgaaaga tcatagctaa tgaaaggcac tcactcatat tgtttacttt aaaatattta taaatangcc ttaaagaaat acaaatgata ncaattanan annnnannna nnnnnntaat ttcctctgta tttgtgtaga tactttg &lt; 210 &gt; 275 60 120 180 240 300 360 420 480 540 98677.doc -215 - 577 200533758 &lt; 211〉 477 &lt; 212〉 DNA &lt; 213〉 human &lt; 220 &gt; &lt; 223 &gt; Probe 3746l.at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 (26) .. (26) &lt; 223> n is a, g, c or t

&lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （326)..(343) &lt;223〉n 為 a，g，c 或 t &lt;400〉 275 60 120 180 240 300 360 420 cgctcaaggc cacaaccatg atgatncgac cagcagattt ctaaacatcc cagtccacct gaggaactgt ctcgaactat tttcaaagac ttaagcccag tgcactgaaa gtcacggctg cgcactgtgt cctcttccac cacagagggc gtgtgctcgg tgctgacggg acccacatgc&lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222〉 (326) .. (343) &lt; 223〉 n is a, g, c or t &lt; 400〉 275 60 120 180 240 300 360 420 cgctcaaggc cacaaccatg atgatncgac cagcagattt ctaaacatcc cagtccacct gaggaactgt ctcgaactat tttcaaagac ttaagcccag tgcactgaaa gtcacggctg cgcactgtgt cctcttccac cacagagggc gtgtgctcgg tgctgacggg acccacatgc

tccagattag agcctgtaaa ctttatcact taaacttgca tcacttaacg gaccaaagca agaccctaaa catccataat tgtgattaga cagaacacct atgcaaagat gaacccgagg ctgagaatca gactgacagt ttacannnnn nnnnnnnnnn nnnaagaatg ttatgtgcaa §tttatcagt aaataactgg aaaacagaac acttatgtta tacaatacag atcatcttgg aactgcattc ttctgagcac tgtttataca ctgtgtaaat acccatatgt cctgaat &lt;210&gt; 276 986^7.doc -216- 477tccagattag agcctgtaaa ctttatcact taaacttgca tcacttaacg gaccaaagca agaccctaaa catccataat tgtgattaga cagaacacct atgcaaagat gaacccgagg ctgagaatca gactgacagt ttacannnnn nnnnnnnnnn nnnaagaatg ttatgtgcaa §tttatcagt aaataactgg aaaacagaac acttatgtta tacaatacag atcatcttgg aactgcattc ttctgagcac tgtttataca ctgtgtaaat acccatatgt cctgaat &lt; 210 &gt; 276 986 ^ 7.doc -216- 477

200533758 &lt;211&gt; 475 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223〉 Probe 37484一at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 104..165, 252..270, 359..361, 365..379 &lt;223〉n 為 a，g，c 或 t200533758 &lt; 211 &gt; 475 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220〉 &lt; 223〉 Probe 37484-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; 104..165 , 252..270, 359..361, 365..379 &lt; 223> n is a, g, c or t

&lt;400&gt; 276 tcttctgaca tcagccaagt caatgtttcg cttatcttgt ggaaaccaac ttttataaaa tcatattttt ccagcttaaa tcttactata aggggagaac ttcnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnatatc caaagatggg ctaccgggca gagtgccatt atgggtcatc ctgctgagtg cttttgccgg attgttgctg ttaatgctgc tnnnnnnnnn nnnnnnnnnn attggattct tcaaaagacc actgaaaaag aaaatggaga aatgaaatat tttacgaaag aaaataataa caattattca ataatctann ntcannnnnn nnnnnnnnnt gtgacaagaa atgtataatt catgacatag tcatgtaact atgtaatcca tcagggattc attacttgga aaatgacagg tcatgcatta tccaa &lt;210&gt; 277 &lt;211&gt; 442 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 37493—at HG-U95Av2 60 120 180 240 300 360 420 475 98677.doc -217- 60 200533758 &lt;400〉 277 120 180 240 300 360 420 442 caaagcagtg tttgtcctaa tttatatatt gtttttctag ttcattttgt gtttccaact tttcatgtaa aattttaatt atttttgaat gtgtggatgt gagactgagg tgccttttgg tactgaaatt ctttttccat gtacctgaag tgttactttt gtgatatagg aaatccttgt atatatactt tattggtccc taggcttcct attttgttac cttgctttct ctatggcatc caccatittg attgttctac ttttatgata tgttttcata agtggttaag caagtattct 鲁 cgttactttt gctcttaaat ccctattcat tacagcaatg ttggtggtca aagaaaatga taaacaactt gaatgttcaa tggtcctgaa atacataaca acattttagt acattgtaaa gtagaatcct ctgttcataa tg &lt;210〉 278 &lt;211&gt; 435 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; w &lt;223&gt; Probe 37494„at HG-U95Av2 &lt;220&gt; &lt;221&gt; mi sc—feature &lt;222〉 （155)..(182) &lt;223〉n 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （220)..(259) &lt;223〉n 為 a，g，c 或 t 08677.doc -218 - 60 200533758 &lt;400&gt; 278 gcccccttgg gaggtcaaca agcctgggga ggtgtgttga gacccccagg cctagacagg caaggggatg gagagggctt gccttccctc ccgcctgacc ttcctcagtc atttctgcaa agccaagggg cagcctcctg tcaaggtagc tagannnnnn nnnnnnnnnn nnnnnnnnnn nnggccccct tgaccttcag caaatcactt ctctccctgn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt ttttcctgtc aggttaactt atttgtaggt tctgcattat&Lt; 400 &gt; 276 tcttctgaca tcagccaagt caatgtttcg cttatcttgt ggaaaccaac ttttataaaa tcatattttt ccagcttaaa tcttactata aggggagaac ttcnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnatatc caaagatggg ctaccgggca gagtgccatt atgggtcatc ctgctgagtg cttttgccgg attgttgctg ttaatgctgc tnnnnnnnnn nnnnnnnnnn attggattct tcaaaagacc actgaaaaag aaaatggaga aatgaaatat tttacgaaag aaaataataa caattattca ataatctann ntcannnnnn nnnnnnnnnt gtgacaagaa atgtataatt catgacatag tcatgtaact atgtaatcca tcagggattc attacttgga aaatgacagg tcatgcatta tccaa &lt; 210 &gt; 277 &lt; 211 &gt; 442 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 37493-at HG-U95Av2 60 120 180 240 300 360 420 475 98677.doc- 217- 60 200533758 &lt; 400〉 277 120 180 240 300 360 420 442 caaagcagtg tttgtcctaa tttatatatt gtttttcctag ttcattttgt gtttccaact tttcatgtaa aattttaatt atttttgaat gtgtggattttttctctt cttt cctttcc cttgctttct ctatggcatc caccatittg attgttctac ttttatgata tgttttcata agtggttaag caagtattct Lu cgttactttt gctcttaaat ccctattcat tacagcaatg ttggtggtca aagaaaatga taaacaactt gaatgttcaa tggtcctgaa atacataaca acattttagt acattgtaaa gtagaatcct ctgttcataa tg &lt; 210> 278 &lt; 211 &gt; 435 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; w &lt; 223 &gt; Probe 37494 „at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222〉 (155) .. (182) &lt; 223> n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222〉 (220) .. (259) &lt; 223〉 n is a, g, c or t 08677.doc -218-60 200533758 &lt; 400 &gt; 278 gcccccttgg gaggtcaaca agcctgggga ggtgtgttga gacccccagg cctagacagg caaggggatg gagagggctt gccttccctc ccgcctgacc ttcctcagtc atttctgcaa agccaagggg cagcctcctg tcaaggtagc tagannnnnn nnnnnnnnnn nnnnnnnnnn nnggccccct tgaccttcag caaatcactt ctctccctgn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt ttttcctgtc aggttaactt atttgtaggt tctgcattat

120 180 240 300 360 420 435 tagaactttc tagatatact cattccatct ccccctcatt tttttaatca ggtttccttg cttttgccat ttttcttcct tcttttttea ctgatttatt atgagagtgg ggctgaggtc tgagctgagc ettat &lt;210〉 279 &lt;211〉 442 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; # &lt;223〉 Probe 37514—s—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （315)..(336) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 279 60 ctgaacctgt gttcgggcgc ctggcatccc ccggctttcc aggggagtat gccaatgacc aggageggeg ctggaccctg actgcacccc ccggctaccg cctgcgcctc tacttcaccc 9^677.doc -219- 120 200533758 acttcgacct ccaaggtgct aggacacttt acgagaagcc aggtggcccc tctactgctc ggagctctcc ggccacgctg ctactcgctg gttcnnnnnn gggagaggcg ctgccgcgca cacctctgcg tgcgggcagg ggctccagcc nnnnnnnnnn cccacctgcg gg agtacgactt agagcacaga tggacattac nnnnnncagc accaccactg cgtcaagctg cacggagcgg cttccgctcc cgaggacatt ccacaaccac agctcggggg gcccctggca gactactcca gacgagtgcc ctgggcggtt 180 240 300 360 420 442120 180 240 300 360 420 435 tagaactttc tagatatact cattccatct ccccctcatt tttttaatca ggtttccttg cttttgccat ttttcttcct tctttttteatea ctgatttatt atgagagtgg ggctgaggtc tgagctgagc ettat &lt; 210> 279 &lt;212;lt;lt; 210 &lt;212; lt &lt; 212 Probe 37514-s-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (315) .. (336) &lt; 223 &gt; n is a, g, c or t &lt; 400> 279 60 ctgaacctgt gttcgggcgc ctggcatccc ccggctttcc aggggagtat gccaatgacc aggageggeg ctggaccctg actgcacccc ccggctaccg cctgcgcctc tacttcaccc 9 ^ 677.doc -219- 120 200533758 acttcgacct ccaaggtgct aggacacttt acgagaagcc aggtggcccc tctactgctc ggagctctcc ggccacgctg ctactcgctg gttcnnnnnn gggagaggcg ctgccgcgca cacctctgcg tgcgggcagg ggctccagcc nnnnnnnnnn cccacctgcg gg agtacgactt agagcacaga tggacattac nnnnnncagc accaccactg cgtcaagctg cacggagcgg cttccgctcc cgaggacatt ccacaaccac agctcggggg gcccctggca gactactcca gacgagtgcc ctgggcggtt 180 240 300 360 420 442

&lt;210&gt; 280 &lt;211&gt; 532 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 37534一at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （142)..(158) &lt;223〉η 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc__feature &lt;222〉 （273)..(305) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （430)..(458) &lt;223〉n 為 a，g，c 或 t 98677.doc -220-&lt; 210 &gt; 280 &lt; 211 &gt; 532 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223> Probe 37534-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222〉 (142) .. (158) &lt; 223> η is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc__feature &lt; 222> (273) .. (305) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (430) .. (458) &lt; 223> n is a, g, c or t 98677.doc -220-

200533758 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （461)..(488) &lt;223&gt; η 為 a, g，c 或 t &lt;220〉 &lt;221&gt; misc—feature &lt;222〉 （319)..(319) &lt;223&gt; n 為 a, g，c 或 t &lt;400&gt; 280 cttttatatg ctaaaggagc atctatcaga ttaagttaga acatttgctg tcagccacat attgagatga cactaggtgc aatagcaggg atagattttg ttggtgagta gtctcatgcc ttgagatctg tggtggtctt cnnnnnnnnn nnnnnnnnga tcaaggatgt agtatctcat agttcccagg tgatattttt cttattagaa aaatattata actcatttgt tgtttgacac ttatagattg aaatttecta atttatteta aannnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnttgtt gttgttttng gatggtgtta catattatat gttctagaaa catgtaatcc200533758 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 (461) .. (488) &lt; 223 &gt; η is a, g, c or t &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (319) .. (319) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 280 cttttatatg ctaaaggagc atctatcaga ttaagttaga acatttgctg tcagccacat attgagatga cactaggtgc aatagcaggg atagattttg ttggtgagta gtctcatgcc ttgagatctg tggtggtctt cnnnnnnnnn nnnnnnnnga tcaaggatgt agtatctcat agttcccagg tgatattttt cttattagaa aaatattata actcatttgt tgtttgacac ttatagattg aaatttecta atttatteta aannnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnttgtt gttgttttng gatggtgtta catattatat gttctagaaa catgtaatcc

taaatttacc ctcttgaata taatccctgg atgatatttt ttatcataaa tgcagaataa tcaaatacan nnnnnnnnnn nnnnnnnnnn nnnnnnnntt nnnnnnnnnn nnnnnnnnnn nnnnnnnngt tgctgttgtg tgatcaaaca tgtctctgtg tagttccagc aa 60 120 180 240 300 360 420 480 532 &lt;210〉 281 &lt;211&gt; 519 &lt;212〉 DNA &lt;213&gt; 人類 98677.doc 221 -taaatttacc ctcttgaata taatccctgg atgatatttt ttatcataaa tgcagaataa tcaaatacan nnnnnnnnnn nnnnnnnnnn nnnnnnnntt nnnnnnnnnn nnnnnnnnnn nnnnnn &lt; &lt;210; 210 &lt;210; 480> 221-

200533758 &lt;220&gt; &lt;223&gt; Probe 37565—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （412)·.(431) &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (28)..(28) 鲁 &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 281 agtccatgag ttatatcctg gctcagtngg agtgatattt atgtattatt tttacttttc tctcagtgtc ttatattaag attaacatgt tgttaatagt tgctttgttg attaatctct cttgttggtg ttttaataaa tgaaataggc ttgcctttag atcgggtgct gatattgcct gtttcctagt aatgggctga tcaaatgatc agtggaattc ttggtttgat gataacctta ttaattgaaa ttttttactg atgtggcttt aaaagaggtt tattttgtat atgtttagaa ctctctgatt ttgatgaatt atatgggaat gagaaacaga agaagtggta tttgctggcg agttaaatag gcaaggtacc cagtgataac accaaccaaa ccactcctat cnnnnnnnnn nnnnnnnnnn ngatgcctgt tgttttactg tgtatatttt atttttaata tattaacttt gtggatteat ttaaggtcta ctcaaaagta acactgtca200533758 &lt; 220 &gt; &lt; 223 &gt; Probe 37565—at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 (412) ·. (431) &lt; 223> n is a, g, c Or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (28) .. (28) Lu &223; n is a, g, c or t &lt; 400 &gt; 281 agtccatgag ttatatcctg gctcagtngg agtgatattt atgtattatt tcttattatc attaacatgt tgttaatagt tgctttgttg attaatctct cttgttggtg ttttaataaa tgaaataggc ttgcctttag atcgggtgct gatattgcct gtttcctagt aatgggctga tcaaatgatc agtggaattc ttggtttgat gataacctta ttaattgaaa ttttttactg atgtggcttt aaaagaggtt tattttgtat atgtttagaa ctctctgatt ttgatgaatt atatgggaat gagaaacaga agaagtggta tttgctggcg agttaaatag gcaaggtacc cagtgataac accaaccaaa ccactcctat cnnnnnnnnn nnnnnnnnnn ngatgcctgt tgttttactg tgtatatttt atttttaata tattaacttt gtggatteat ttaaggtcta ctcaaaagta acactgtca

&lt;210&gt; 282 &lt;211&gt; 404 &lt;212&gt; DNA 60 120 180 240 300 360 420 480 9S677.doc -222- 519 200533758 &lt;213&gt; 人類 &lt;220&gt; &lt;223&gt; Probe 37608_g—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （163)..(254) &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 282 60 120 180 240 300 360 404 • ttccagtcag cagaggaagc cttgaggggc ttgtatggtc gtgtgaggaa aggggctgtg cttgtctgtg cctgggctga ggagggcgcc gacgccctgg gccctgatgg caaattgctc cactcggatg ctttcccgcc accccgcgtg gtggatacac tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncggcaa gaagtgtggc ctgcagggct ttgatggcat cgtgtgagag caggtgccgg ctcctcacac accatggaga ctaccattgc ggctgcatcg ccttctcccc tccatccagc ctggcgtcca ggttgccctg ttcaggggac agat &lt;210〉 283 &lt;211&gt; 402 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 3761l_at HG-U95Av2 &lt;220&gt; &lt;221〉 misc一feature &lt;222&gt; (160)..(182) 98677.doc - 223 &gt; 200533758 &lt;223〉η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （184)..(184) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 283 ggatcgtiat ctactgacia tattttccct tattactgct tgcagtaatt caactggaaa ttaaaaaaaa tagctttgag nnangttact taagatttgt attatattct gtagcatttt aaaactagac atttcagcta aatatatctg acatattatc gtttattatg tctaataggt tccattgtgc tgctagaggc taacactatt atcctataaa acaaatgaaa actgccatat cttactaaat ttttattagn acagtattgc gaaacggtat gagaaaatat ttttctgtgt atgggaatgt nnnnnnnnnn tatttatatt gacttaattt atatttttaa gg ctaacttaaa nnnnnnnnnn cattcagata tagaaagaaa tggaaagttt 60 120 180 240 300 360 402 # &lt;210&gt; 284 &lt;211〉 437 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37637—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 48..50, 53, 93, 352 &lt;223&gt; n 為 a，g，c 或 t 98677.doc 224 - 60 200533758 &lt;400〉 284 120 180 240 300 360 420 437 tccttaaaga actggctgat ggggcaggag gtccaggcct gggctctnnn ggncctecta gagggccatt ggagettgea gctcagaccc ccnactttga gttttattta tttaaatagt agttggatgc ttggcacgtc gtcctgtaat aggaaaccct tgcctcatca gttttcctga tttacaagtg caatatttta gccaatgcct tgggagaagc tgccatgcaa aggtggacac cattciccag citcagggga tatgetegte ccgggcaccg gtggcaggca gctggccttc _ tggactaagg cagcctgggg ggacactgca gtctggctac acacagagat cntggcaccc cctgggtgga gtgtccctcg ggggctttgg gaaagcatgg caccctcaga ccacacagta gccaagttct ggagcaa &lt;210〉 285 &lt;211&gt; 486 &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220&gt; Φ &lt;223〉 Probe 37645_at HG-U95Av2 &lt;220〉 &lt;221〉mi sc一feature &lt;222〉 （397)..(411) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 285 60 catttgcact actggaagga gttagatgtt ggtactagat actgaatgta aacaaaggaa ttatggctgg taacataggt ttttagtcta attgaatccc ttaaactcag ggagcattta 98677.doc -225 - 120 200533758 taaatggaca aatgcttatg aaattaagat ttgtaatatt tctctctttt tagagaaatt 180 tgccaattta ctttgttatt tttccccaaa aagaatggga tgatcgtgta tttatttttt 240 tacttcctca gctgtagaca ggtccttttc gatggtacat atttctttgc ctttataatc 300 ttttatacag tgtcttacag agaaaagaca taagcaaaga ctatgaggaa tatttgcaag 360 acatagaata gtgttggaaa atgtgcaata tgtgatnnnn nnnnnnnnnn ntaggaaata 420 ttctgtaatc itcagaccta gaataataci agtcttataa taggittgtg actttcctaa 480 • atcaat 486 &lt;210〉 286 &lt;211〉 501 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37695jt HG-U95Av2 &lt;220〉 &lt;221&gt; misc.feature 鲁 &lt;222〉 （449)..(457) &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （224)..(287) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 286 gggcctgcgt taaaacctaa ttgctaatgc ttcacaacta ggagagcatg ccgtcttgat 60 98677.doc - 226 - 200533758 gtttaaaaaa cccagggtct ccacccttcc tttgatttgt gcaattctgt cttccacagt 120 tccggagcct tcagtgaggg gtagctacat gccccatgcc tgccctttct ttccttcttt 180 gctcacttta ctatgggtgt attttaatct tgtataaaaa tatnnnnnnn nnnnnnnnnn 240 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnaaa cagatttgat 300 ttgtgttttt gaaatgtcag tacattttgt gccactaaca ctgtgatgta taaaagagct 360 gtttgaatgc cttttaatgt tgtgttitgt actctggaat catatggaaa aagtttgatt 420 • tgtaatttca atacatattt taaatgtann nnnnnnnacg tagtttgtcc ccccctttag 480 cagggattcc tttttaaagc t 501 &lt;210〉 287 &lt;211〉 577 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 37701一at HG-U95Av2&lt; 210 &gt; 282 &lt; 211 &gt; 404 &lt; 212 &gt; DNA 60 120 180 240 300 360 420 480 9S677.doc -222- 519 200533758 &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 37608_g-at HG- U95Av2 &lt; 220〉 &lt; 221 &gt; misc ^ feature &lt; 222〉 (163) .. (254) &lt; 223〉 n is a, g, c or t &lt; 400 &gt; 282 60 120 180 240 300 360 360 404 • ttccagtcag cagaggaagc cttgaggggc ttgtatggtc gtgtgaggaa aggggctgtg cttgtctgtg cctgggctga ggagggcgcc gacgccctgg gccctgatgg caaattgctc cactcggatg ctttcccgcc accccgcgtg gtggatacac tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncggcaa gaagtgtggc ctgcagggct ttgatggcat cgtgtgagag caggtgccgg ctcctcacac accatggaga ctaccattgc ggctgcatcg ccttctcccc tccatccagc ctggcgtcca ggttgccctg ttcaggggac agat &lt; 210> 283 &lt; 211 &gt; 402 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 3761l_at HG-U95Av2 &lt; 220 &gt; &lt; 221> misc-feature &lt; 222 &gt; (160) .. (182) 98677.doc -223 &gt; 200533758 &lt; 223> η is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc ^ feature &lt; 222〉 (184) .. (184) &lt; 223 &gt; n is a, g, c or t &lt; 400> 283 ggatcgtiat ctactgacia tattttccct tattactgct tgcagtaatt caactggaaa ttaaaaaaaa tagctttgag nnangttact taagatttgt attatattct gtagcatttt aaaactagac atttcagcta aatatatctg acatattatc gtttattatg tctaataggt tccattgtgc tgctagaggc taacactatt atcctataaa acaaatgaaa actgccatat cttactaaat ttttattagn acagtattgc gaaacggtat gagaaaatat ttttctgtgt atgggaatgt nnnnnnnnnn tatttatatt gacttaattt atatttttaa gg ctaacttaaa nnnnnnnnnn cattcagata tagaaagaaa tggaaagttt 60 120 180 240 300 360 402 # &lt; 210 &gt; 284 &lt; 211〉 437 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 37637-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> 48..50, 53, 93, 352 &lt; 223 &gt; n is a, g, c or t 98677.doc 224-60 200533758 &lt; 400〉 284 120 180 240 300 360 420 437 tccttaaaga actggctgat ggggcaggag gtccaggcct gggctctnnn ggncctecta gagggccatt ggagettgetta gctcagacc gctcagacc tttaaatagt agttggatgc ttggcacgtc gtcctgtaat aggaaaccct tgcctcatca gttttcctga tttacaagtg caatatttta gccaatgcct tgggagaagc tgccatgcaa aggtggacac cattciccag citcagggga tatgetegte ccgggcaccg gtggcaggca gctggccttc _ tggactaagg cagcctgggg ggacactgca gtctggctac acacagagat cntggcaccc cctgggtgga gtgtccctcg ggggctttgg gaaagcatgg caccctcaga ccacacagta gccaagttct ggagcaa &lt; 210> 285 &lt; 211 &gt; 486 &lt; 212 &gt; DNA &lt; 213 &gt; Humans &lt; 220 &gt; Φ &lt; 223〉 Probe 37645_at HG-U95Av2 &lt; 220〉 &lt; 221〉 mi sc-feature &lt; 222〉 (397) .. (411) &lt; 223 &gt; n is a, g, c or t &lt; 400> 285 60 catttgcact actggaagga gttagatgtt ggtactagat actgaatgta aacaaaggaa ttatggctgg taacataggt ttttagtcta attgaatccc ttaaactcag ggagcattta 98677.doc -225 - 120 200533758 taaatggaca aatgcttatg aaattaagat ttgtaatatt tctctctttt tagagaaatt 180 tgccaattta ctttgttatt tttccccaaa aagaatggga tgatcgtgta tttatttttt 240 tacttcctca gctgtagaca ggtccttttc gatggtacat atttctttgc ctttataatc 300 ttttatacag tgtcttacag agaaaagaca taagcaaaga ctatgaggaa tatttgcaag 360 acatagaata gtgttggaaa atgtgcaata tgtgatatnnnn nnnnnnnnnn ntaggaaata 420 ttctgtaatc itcagaccta gaataataci agtcttataa &&;; 220 &lt;212; lt &lt;212; lt &lt;212; lt &lt; 212 &lt; 212 37695jt HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc.feature Lu & 222> (449) .. (457) &lt; 223〉 n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222> (224) .. (287) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 286 gggcctgcgt taaaacctaa ttgctaatgc ttcacaacta ggagagcatg ccgtcttgat 60 98677.doc-226-200533758 ccgttttt aaa 120 tccggagcct tcagtgaggg gtagctacat gccccatgcc tgccctttct ttccttcttt 180 gctcacttta ctatgggtgt attttaatct tgtataaaaa tatnnnnnnn nnnnnnnnnn 240 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnaaa cagatttgat 300 ttgtgttttt gaaatgtcag tacattttgt gccactaaca ctgtgatgta taaaagagct 360 gtttgaatgc cttttaatgt tgtgttitgt actctgg aat catatggaaa aagtttgatt 420 • tgtaatttca atacatattt taaatgtann nnnnnnnacg tagtttgtcc ccccctttag 480 cagggattcc tttttaaagc t 501 &lt; 210〉 287 &lt; 211〉 577 &lt; 212 &gt; DNA &lt; 213> Humans &lt; 701 U95Av2

&lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 28..42, 145, 194, 220, 239, 301, 306, 319, 324, 329, 352..368 &lt;223〉n 為 a, g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 386, 447..462 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 287 cataaagact gaccttgaat tcagcctnnn nnnnnnnnnn nnatcactca gaactattga 60 98677.doc -227- 120 200533758 ttcaaagttg ggtagtgaat caggaagcca gtaactgact aggagaagct ggtatcagaa cagcttccct cactgtgtac agaancgcaa gaagggaata ggtggtctga acgtggtgtc tcactctgaa aagncaggaa tgtaagatga tgaaagagan caatgtaata ctgttggtnc caaaagcatt taaaatcaat agatctggga ttatgtggcc ttaggtagct ggttgtacat netttnccct aaatcgatnc catngttanc cacatagtag ttttagttta gnnnnnnnnn nnnnnnnngt gtttactatg tgcaanggta ttgaagttct tatgaccaca gatcatcagt&lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; 28..42, 145, 194, 220, 239, 301, 306, 319, 324, 329, 352..368 &lt; 223> n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 386, 447..462 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 287 cataaagact gaccttgaat tcagcctnnn nnnnnnnnnnnn nnatcactca gaactattga 60 98 .doc -227- 120 200533758 ttcaaagttg ggtagtgaat caggaagcca gtaactgact aggagaagct ggtatcagaa cagcttccct cactgtgtac agaancgcaa gaagggaata ggtggtctga acgtggtgtc tcactctgaa aagncaggaa tgtaagatga tgaaagagan caatgtaata ctgttggtnc caaaagcatt taaaatcaat agatctggga ttatgtggcc ttaggtagct ggttgtacat netttnccct aaatcgatnc catngttanc cacatagtag ttttagttta gnnnnnnnnn nnnnnnnngt gtttactatg tgcaanggta ttgaagttct tatgaccaca gatcatcagt

actgttgtct catgtaatgc taaaacnnnn nnnnnnnnnn nntgcattgt taaaaatgat gtgtgaaata gaatgagtgc tatggtgttg aaaactgcag tgtccgttat gagtgccaaa aatctgtctt gaaggeaget acactttgaa gtggtct &lt;210〉 288 &lt;211〉 491 &lt;212&gt; DNA &lt;213〉人類 籲 &lt;220〉 &lt;223〉 Probe 37712_g—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （96)..(101) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc^feature &lt;222〉 （106)..(134) &lt;223〉n 為 a，g，c 或 t 180 240 300 360 420 480 540 577 9S677.doc -228 - 60 200533758 &lt;400&gt; 288 gaggatatcc atcagccatt tcaacaacat atggtaccga gtactctctg agtagtgcag acctgtcatc tctgtctggg tttaacaccg ccagcnnnnn ncaccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnacacct acataacatg ccaccatctg ccctcagtca gttgggagct tgcactagca ctcatttatc tcagagttca aatctctccc tgccttctac tcaaagcctc aacatcaagt cagaacctgt ttctcctcct agagaccgta ccaccacccc ttcgagatacactgttgtct catgtaatgc taaaacnnnn nnnnnnnnnn nntgcattgt taaaaatgat gtgtgaaata gaatgagtgc tatggtgttg aaaactgcag tgtccgttat gagtgccaaa alt &220; &gt; 210> 212; ltgt> 210; gtgggtctgt gt> -U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> (96) .. (101) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222〉 (106) .. (134) &lt; 223〉 n is a, g, c or t 180 240 300 360 420 480 540 577 9S677.doc -228-60 200533758 &lt; 400 &gt; 288 gaggatatcc atcagccatt tcaacaacat atggtaccga gtactctctg agtagtgcag acctgtcatc tctgtctggg tttaacaccg ccagcnnnnn ncaccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnacacct acataacatg ccaccatctg ccctcagtca gttgggagct tgcactagca ctcatttatc tcagagttca aatctctccc tgccttctac tcaaagcctc aacatcaagt cagaacctgt ttctcctcct agagaccgta ccaccacccc ttcgagatac

ccacaacaca cgcgccacga ggcggggaga tctcctgttg acagcttgag cagctgtagc agttcgtacg acgggagcga ccgagaggat caccggaacg aattccactc ccccattgga ctcaccagac cttcgccgga cgaaagggaa agtccctcag tcaagcgcat gcgactttct gaaggatggg c &lt;210〉 289 &lt;211&gt; 585 &lt;212〉 DNA 修&lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 37745—s—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 72, 89·.103， 139， 194..202, 204·.206, 208, 209, 212 &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc一feature &lt;222&gt; 214..216, 229, 230, 232, 233, 240..266 120 180 240 300 360 420 480 491 98677.doc -229 - 60 200533758 &lt;223〉η 為 a，g，c 或 t &lt;400&gt; 289 ctgctgtaag ctttcttaac tgttttttgt aacaagcaaa gagaatatgg caaatatttg tatattccca anggggccgg gtgctttcnn nnnnnnnnnn nnnatggatg aagtttcgct gggtgctcgt gactggccna gttttgtgca gctgactgtc tcagccaaac cactgatctt ccctggaggc ctinnnnnnn nncnnncnng cntnnncctg aggtccccnn tnnccagtcn nnnnnnnnnn nnnnnnnnnn gtttctattt tttgctggta caatcagtcc ccatttgtag caccctccga gatggtcagt tgggcctggc tcccagtcag ctacgggtgt tctcaataaa nnnnnntgtt atgtacagga gtccgcatac ccataccctc catggcacca gggtcttagg gtgtcatggg aagcccaccc tggtggccac gatgcggtac caatgtacag ttgtttgggc ggacctttta aaaaaatcaa tgtttttgaa aggcaaaggc cctagtcctc tcattcctcc ccagctctgc cagtgctctc agggcatccc tccttcccat ccaga 120 180 240 300 360 420 480 540 585 φ &lt;210&gt; 290 &lt;211&gt; 532 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 37749—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; (32)..(32) &lt;223〉 n 為 a，g，c 或 t 98677.doc - 230 - 200533758 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （109)..(123) &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （247)..(299) &lt;223〉n 為 a，g，c 或 tccacaacaca cgcgccacga ggcggggaga tctcctgttg acagcttgag cagctgtagc agttcgtacg acgggagcga ccgagaggat caccggaacg aattccactc ccccattgga ctcaccagac cttcgccgga cgaaagggaa agtccctcag tcaagcgcat gcgactttct gaaggatggg c &lt; 210> 289 &lt; 211 &gt; 585 &lt; 212> DNA repair &lt; 213> Human &lt; 220 &gt; &lt; 223> Probe 37745-s-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc ^ feature &lt; 222〉 72, 89 · .103, 139, 194..202, 204 · .206, 208, 209, 212 &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222 &gt; 214..216, 229, 230, 232, 233, 240..266 120 180 240 300 360 420 480 491 98677.doc -229 - 60 200533758 &lt; 223> η is a, g, c or t &lt; 400 &gt; 289 ctgctgtaag ctttcttaac tgttttttgt aacaagcaaa gagaatatgg caaatatttg tatattccca anggggccgg gtgctttcnn nnnnnnnnnn nnnatggatg aagtttcgct gggtgctcgt gactggccna gttttgtgca gctgactgtc tcagccaaac cactgatctt ccctggaggc ctinnnnnnn nncnnncnng cntnnncctg aggtccccnn tnnccagtcn nnnnnnnnnn nnnnnnnnnn gtttctattt tttgctggta caatcagtcc ccatttgtag caccctccga gatggtcagt tgggcctggc tcccagtcag ctacgggtgt tctcaataaa nnnnnntgtt atgtacagga gtccgcatac ccataccctc catggcacca gggtcttagg gtgtcatggg aagcccaccc tggtggccac gatgcggtac caatgtacag ttgtttgggc ggacctttta aaaaaatcaa tgtttttgaa aggcaaaggc cctagtcctc tcattcctcc ccagctctgc cagtgctctc agggcatccc tccttcccat ccaga 120 180 240 300 360 420 480 540 585 φ &lt; 210 &gt; 290 &lt; 211 &gt; 532 &lt; 212 &gt; DNA &lt; 213 &gt; Humans &lt; 220〉 &lt; 223〉 Probe 37749-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; (32) .. (32) &lt; 223> n A, g, c or t 98677.doc-230-200533758 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222> (109) .. (123) &lt; 223 &gt; η is a, g, c or t &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (247) .. (299) &lt; 223> n is a, g, c or t

&lt;400〉 290 ctctgccaga gtagtgaagc taattaaaca cntttggttt ctgaataaat tgaactaaat ccaaactatt tcctaaaatc acaggacatt aaggaccaat agcatctgnn nnnnnnnnnn nnngttatta gctgggaaga ccaattctaa cagcaaataa cagtctgaga ctcctcatac ctcagtggtt agaagcatgt ctctcttgag ctacagtaga ggggaaggga ttgttgtgta gtcaagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt gcctgtccca gagaggcttt ccaatgtagc tcagtaattc ctgttacttt acagacagga aagttccaga aactttaaga acaaactctg aaagacctat gagcaaatgg tgctgaatac ttttttttta aagccacatt tcattgtctt agtcaaagca ggattattaa gtgattattt aaaattcgtt tttttaaatt agcaacttca agtataacaa ctttgaaact gg 60 120 180 240 300 360 420 480 532 &lt;210〉 291 &lt;211&gt; 312 &lt;212&gt; DNA &lt;213&gt; 人類 98677.doc 231 - 200533758 &lt;220〉 &lt;223&gt; Probe 37785一at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 135， 140， 141， 143·.151， 154·.156, 158， 160， 161 &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 163..170, 173, 174, 176..212, 220, 258 &lt;223&gt; n 為 a, g，c 或 taagccacatt tcattgtctt 400> 290 ctctgccaga gtagtgaagc taattaaaca cntttggttt ctgaataaat tgaactaaat ccaaactatt tcctaaaatc acaggacatt aaggaccaat agcatctgnn nnnnnnnnnn nnngttatta gctgggaaga ccaattctaa cagcaaataa cagtctgaga ctcctcatac ctcagtggtt agaagcatgt ctctcttgag ctacagtaga ggggaaggga ttgttgtgta gtcaagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt gcctgtccca gagaggcttt ccaatgtagc tcagtaattc ctgttacttt acagacagga aagttccaga aactttaaga acaaactctg aaagacctat gagcaaatgg tgctgaatac ttttttttta; & lt agtcaaagca ggattattaa gtgattattt aaaattcgtt tttttaaatt agcaacttca agtataacaa ctttgaaact gg 60 120 180 240 300 360 420 480 532 &lt; 210〉 291 &lt; 211 &gt; 312 &lt; 212 &gt; DNA &lt; 213 &gt; human 9867733.doc; 231 223 &gt; Probe 37785-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> 135, 140, 141, 143 · .151, 154 · .156, 158, 160, 161 &lt; 223 &gt; n Is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 163..170, 173, 174, 176. .212, 220, 258 &lt; 223 &gt; n is a, g, c or t

&lt;400&gt; 291 60 120 180 240 300 312 ttgggggcct acagcagcct caccttcagc ttcatgcctc ttccacacag cgtttccatg caggtcaggg gatgggaggg gtccctgagc ccttcccttc ccctctaagg aggcagcaac ggcagagtgg ggaantggan ngnnnnnnnn nctnnntngn ntnnnnnnnn ccnngnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nncagagccn aatgagaagg aaacctcatc tttgcatagc ccatgccntc atggagaggt gacatcatac attcacatgc ttctcaccta agtccccagg gt &lt;210〉 292 &lt;211&gt; 345 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37823^at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature 98677.doc - 232 - 200533758 &lt;222〉 （35)..(35) &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; miscjeature &lt;222&gt; (38)..(38) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 292 60 120 180 240 300 345 cccaggtgca gtgtgacatt attttattat aacanccnca aagagattat ttttaaataa&Lt; 400 &gt; 291 60 120 180 240 300 312 ttgggggcct acagcagcct caccttcagc ttcatgcctc ttccacacag cgtttccatg caggtcaggg gatgggaggg gtccctgagc ccttcccttc ccctctaagg aggcagcaac ggcagagtgg ggaantggan ngnnnnnnnn nctnnntngn ntnnnnnnnn ccnngnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nncagagccn aatgagaagg aaacctcatc tttgcatagc ccatgccntc atggagaggt gacatcatac attcacatgc ttctcaccta agtccccagg gt &lt; 210> 292 &lt; 211 &gt; 345 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 37823 ^ at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature 98677.doc-232-200533758 &lt; 222> (35 ): (35) &lt; 223 &gt; η is a, g, c or t &lt; 220> &lt; 221 &gt; miscjeature &lt; 222 &gt; (38) .. (38) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 292 60 120 180 240 300 345 cccaggtgca gtgtgacatt attttattat aacanccnca aagagattat ttttaaataa

tttaaagcat aatatttctt aaaaagtatt taattatatt taagttgttg atgttttaac tctatctgtc atacatccta gtgaatgtaa aatgcaaaat cctggtgatg tgttttttgt ttttgttttc ctgtgagctc aactaagttc acggcaaaat gtcattgttc tccctcctac ctgtctgtag tgttgtgggg tcctcccatg gatcatcaag gtgaaacact ttggtattct ttggcaatca gtgctcctgt aagtcaaatg tgtgctttgt actgc &lt;210&gt; 293 w &lt;211&gt; 491 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 37830_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 26, 34, 49, 67, 68, 72, 78, 80, 313, 314 &lt;223&gt; n 為 a，g，c 或 t 98677.doc -233 - 60 200533758 &lt;400&gt; 293 acctgcctgc gctctccaga tatganccct gcanccaccc cccacagcnt gccctacccc acctacnntg cntcagcntn ggacttctca gtgggtggag tgccagggag gaggaggcac acggagacct ggggctcggg gcccctggat tcctgcatct gcatatgcgt atttgccaaa gacgacaggg tgggctgggg tgcgctccgg aggaaccccc ggcactgatg ggcttctgcc cctgcccttc ctcacactga cactttgtcc ccacatgggg tggggagcag agtgcccgcc ccgtggagat acnnccccag cgggggctgc gacatccatg gccaccatgg ggcacctggctttaaagcat aatatttctt aaaaagtatt taattatatt taagttgttg atgttttaac tctatctgtc atacatccta gtgaatgtaa aatgcaaaat cctggtgatg tgttttttgt ttttgttttc ctgtgagctc aactaagttc acggcaaaat gtcattgttc tccctcctac ctgtctgtag tgttgtgggg tcctcccatg gatcatcaag gtgaaacact ttggtattct ttggcaatca gtgctcctgt aagtcaaatg tgtgctttgt actgc &lt; 210 &gt; 293 w &lt; 211 &gt; 491 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 37830_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 26, 34, 49, 67, 68, 72, 78, 80, 313, 314 &lt; 223 &gt; n is a, g, c or t 98677.doc -233 - 60 200533758 &lt; 400 &gt; 293 acctgcctgc gctctccaga tatganccct gcanccaccc cccacagcnt gccctacccc acctacnntg cntcagcntn ggacttctca gtgggtggag tgccagggag gaggaggcac acggagacct ggggctcggg gcccctggat tcctgcatct gcatatgcgt atttgccaaa gacgacaggg tgggctgggg tgcgctccgg aggaaccccc ggcactgatg ggcttctgcc cctgcccttc ctcacactga cactttgtcc ccacatgggg tggggagcag agtgcccgcc ccgtggagat acnnccccag cgggggctgc gacatccatg gccaccatgg ggcacctggc

ggggcggggg tctgccggcc tctgggcaag gcccctggag catctcgccc aggcttttta taccttacaa tgtaactttt ttattttatt ttactctatg attattcagg aatattatct ctcagataag t &lt;210&gt; 294 &lt;211&gt; 437 &lt;212&gt; DNA &lt;213〉人類 120 180 240 300 360 420 480 491ggggcggggg tctgccggcc tctgggcaag gcccctggag catctcgccc aggcttttta taccttacaa tgtaactttt ttattttatt ttactctatg attattcagg aatattatct ctcagataag t &lt; 210 &gt; 294 &lt; 211 &gt; 360 &gt; 437 &lt; 212

&lt;223〉 Probe 37841—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （286)..(286) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （339)..(359) &lt;223〉n 為 a，g，c 或 t 9b67，.doc -234 - 60 200533758 &lt;400〉 294 gaaagcagga ttccatcgct ggaacaatta catgatggac tggaaaaatc aatttaacga ttacactagc aagaaagaaa gttgtgtggg tctctaatta atagatttac cctttataga acatattttc ctttagatca aggcaaaaat atcaggagct tttttacaca cctactaaaa aagttattat gtagctgaaa caaaaatgcc agaaggataa tattgattcc tcacatcttt aacttagtat tttacctagc atttcaaaac ccaaatggct agaacntgtt taattaaatt&lt; 223> Probe 37841-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (286) .. (286) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (339) .. (359) &lt; 223〉 n is a, g, c or t 9b67, .doc -234-60 200533758 &lt; 400> 294 gaaagcagga ttccatcgct ggaacaatta catgatggac tggaaaaatc aatttaacga ttacactagc aagaaagaaa gttgtgtggg tctctaatta atagatttac cctttataga acatattttc ctttagatca aggcaaaaat atcaggagct tttttacaca cctactaaaa aagttattat gtagctatat cctagat cc tact aca tact cc tac at cc

tcacaatata aagttctaca gttaattatg tgcatattnn nnnnnnnnnn nnnnnnnnnt tctttctttc cttaataaat ttaagttttt tccccccaaa attatcagtg ctctgctttt agtcacgtgt attttca &lt;210&gt; 295 &lt;211&gt; 582 &lt;212&gt; DNA &lt;213〉 人類 &lt;220&gt; &lt;223〉 Probe 37944_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_ .feature &lt;222&gt; (138)..(139) &lt;223&gt; n為 a，g，c 或 t &lt;220&gt; &lt;221&gt; mi sc一 feature &lt;222&gt; (146) ..(146) &lt;223&gt; n為 a，g，c 或 ttcacaatata aagttctaca gttaattatg tgcatattnn nnnnnnnnnn nnnnnnnnnt tctttctttc cttaataaat ttaagttttt tccccccaaa attatcagtg ctctgctttt agtcacgtgt attttca &lt; 210 &gt; 295 &lt; 211 &gt; A &lt;210; &lt; 221 &gt; misc_ .feature &lt; 222 &gt; (138) .. (139) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222 &gt; ( 146) .. (146) &lt; 223 &gt; n is a, g, c or t

120 180 240 300 360 420 437 98677.doc120 180 240 300 360 420 437 98677.doc

200533758 &lt;220&gt; &lt;221&gt; misc^feature &lt;222〉 （153)..(153) &lt;223&gt; η 為 a，g，c 或 t &lt;400〉 295 ccactttgat gctatttggg ttatgatggg gcaagatggc agaggtattg ggtttttttg tttttttcca ttcctctcta cttctgtttc ctagcttttt ctttctggag tttaagtaca gtgatggttg gcttgagnnc cttttnaaat ctngcccagt ataaacatta gcctgcttaa tatttagaca tttataggta gaattctgag cactcaactc atgtttggca ttttaaagta aaaacaagtg tgacttcgag gaccaaagaa attgtcagct atacatttat ctttatgaac tcatttatat tcctttttaa tgactcgttg ttctaacatt tcctagaagt gttcttataa aggtctaatg tatccacagg ctgttgtctt attagtaaat gcaaagtaat gactttgtct gttttactct agtctttagt acttcaaaat taccttttca tatccatgat cttgagtcca tttgggggat ttttaagaat ttgatgtatt tcaatacact gttcaaaatt aaattgttta attttatgta tgagtatgta tgttcctgaa gttggtccta tt &lt;210&gt; 296 &lt;211&gt; 432 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 38022_s_at HG-U95Av2 60 120 180 240 300 360 420 480 540 582 98677.doc - 236 - 200533758 &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; (39)..(65) &lt;223〉 η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc—feature &lt;222&gt; (234)..(340) &lt;223&gt; n 為 a，g，c 或 t φ &lt;220&gt; &lt;221&gt; misc—feature &lt;222&gt; (377)..(402) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 296200533758 &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222〉 (153) .. (153) &lt; 223 &gt; η is a, g, c or t &lt; 400> 295 ccactttgat gctatttggg ttatgatggg gcaagatggc agaggtattg gttttctcttttc cttctgtttc ctagcttttt ctttctggag tttaagtaca cttttnaaat gtgatggttg gcttgagnnc aaattgttta attttatgta tgagtatgta ctngcccagt ataaacatta gcctgcttaa tatttagaca tttataggta gaattctgag cactcaactc atgtttggca ttttaaagta aaaacaagtg tgacttcgag gaccaaagaa attgtcagct atacatttat ctttatgaac tcatttatat tcctttttaa tgactcgttg ttctaacatt tcctagaagt gttcttataa aggtctaatg tatccacagg ctgttgtctt attagtaaat gcaaagtaat gactttgtct gttttactct agtctttagt acttcaaaat taccttttca tatccatgat cttgagtcca tttgggggat ttttaagaat ttgatgtatt tcaatacact gttcaaaatt tgttcctgaa gttggtccta tt &lt; 210 &gt; 296 &lt; 211 &gt; 432 &lt; 212〉 DNA &lt; 213〉 human &lt; 220 &gt; &lt; 223 &gt; Probe 38022_s_at HG-U95Av2 60 120 180 240 300 360 420 480 540 582 98677.doc-236- 200533758 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222 &gt; (39): (65) &lt; 223> η is a, g, c or t &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; (234) .. (340) &lt; 223 &gt; n is a, g, c Or t φ &lt; 220 &gt; &lt; 221 &gt; misc—feature &lt; 222 &gt; (377) .. (402) &lt; 223 &gt; n is a, g, c or t &lt; 400> 296

60 120 180 240 300 360 420 tcaacaaggg cctggtggac aagatcatgg tggaccgcnn nnnnnnnnnn nnnnnnnnnn nnnnnggctt cgaggaccca cgcaccaaga ccaagatgtc ggccgcccag gccctgaaga agggctggct ctactacgag gccggccagc gcttcctgga ggtgcagtac ctgaccggcg gcttgatcga gcccgacacg ccgggccgcg tgcccctgga cgaggccctg cagnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn getggaccgc agcatggtgg aggagggeae ggggctnnnn nnnnnnnnnn nnnnnnnnnn nnccaccaag ggctactaca gcccctacag eg &lt;210〉 297 &lt;211〉 429 98677.doc - 237- 432 200533758 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 38062一at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （116)..(133)&lt;223〉n 為 a，g，c 或 t φ &lt;220&gt; &lt;221〉 raisc^feature &lt;222〉 （400)..(400)&lt;223&gt; n 為 a，g，c 或 t &lt;400〉 297 60 120 180 240 300 360 420 429 &lt;210&gt; 298 &lt;211&gt; 385 aaatcagtga cctgaagcaa gaaatcttgc cttttaatgt atcattaatt agggctgctg tgatattgtc agcttgcatt aacaattaga agatagagaa cccgccatca gggtgnnnnn nnnnnnnnnn nnngactaca cttggtagtt ttccaccatt taaagaactg gtaaatatga aacatttgtt gagttaccag aattgccatt aacagtgttt tctttcccat attccatgct ttctgcctct gtgtatatat ataatatata tgtatatgac tgtgctgtgt atttatcgaa gctagtaagc aataatttat atgtaaaaat ggccaagcaa tataaggtta aaacttatat aagtaaccct taccttatct tgtattttca attttttttn aaaactgctt ttccaaatat gagactatg 98677.doc 238 - 200533758 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 38066—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc-feature &lt;222〉 （90)..(90) &lt;223〉n 為 a，g，c 或 t φ &lt;220&gt; &lt;221&gt; misc—feature &lt;222〉 （97)..(97) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 29860 120 180 240 300 360 420 tcaacaaggg cctggtggac aagatcatgg tggaccgcnn nnnnnnnnnn nnnnnnnnnn nnnnnggctt cgaggaccca cgcaccaaga ccaagatgtc ggccgcccag gccctgaaga agggctggct ctactacgag gccggccagc gcttcctgga ggtgcagtac ctgaccggcg gcttgatcga gcccgacacg ccgggccgcg tgcccctgga cgaggccctg cagnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn getggaccgc agcatggtgg aggagggeae ggggctnnnn nnnnnnnnnn nnnnnnnnnn nnccaccaag ggctactaca gcccctacag eg &lt; 210〉 297 &lt; 211〉 429 98677.doc-237- 432 200533758 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 38062-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (116) .. (133) &lt; 223〉 n is a, g, c or t φ &lt; 220 &gt; &lt; 221〉 raisc ^ feature &lt; 222〉 (400) .. (400) .. 400) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 297 60 120 180 240 300 360 420 429 &lt; 210 &gt; 298 &lt; 211 &gt; 385 aaatcagtga cctgaagcaa gaaatcttgc cttttaatgt atcattaatt agggctgctg tgatattgt a ttgcatt aacaattaga agatagagaa cccgccatca gggtgnnnnn nnnnnnnnnn nnngactaca cttggtagtt ttccaccatt taaagaactg gtaaatatga aacatttgtt gagttaccag aattgccatt aacagtgttt tctttcccat attccatgct ttctgcctct gtgtatatat ataatatata tgtatatgac tgtgctgtgt atttatcgaa gctagtaagc aataatttat atgtaaaaat ggccaagcaa tataaggtta aaacttatat aagtaaccct taccttatct tgtattttca attttttttn aaaactgctt ttccaaatat gagactatg 98677.doc 238 - 200533758 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223〉 Probe 38066—at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 (90) .. (90) &lt; 223〉 n is a, g, c or t φ &lt; 220 &gt; &lt; 221 &gt; misc—feature &lt; 222> (97) .. (97) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 298

60 120 180 240 300 360 385 ctgatctata caaattttca gaaggttatt ttctttatca ttgctaaact gatgacttac catgggatgg ggtccagtcc catgaccttn ggggtancaa ttgtaaacct agagttttat caactttggt gaacagtttt ggcataatag tcaatttcta cttctggaag tcatctcatt ccactgttgg tattatataa ttcaaggaga atatgataaa acactgccct cttgtggtgc attgaaagaa gagatgagaa atgatgaaaa ggttgcctga aaaaigggag acagcctctt acttgccaag aaaatgaagg gattggaccg agctggaaaa cctcctttac cagatgctga ctggcactgg tggtttttgc tctcg &lt;210〉 299 &lt;211〉 540 &lt;212&gt; DNA &lt;213〉 人類 98677.doc 239 -60 120 180 240 300 360 385 ctgatctata caaattttca gaaggttatt ttctttatca ttgctaaact gatgacttac catgggatgg ggtccagtcc catgaccttn ggggtancaa ttgtaaacct agagttttat caactttggt gaacagtttt ggcataatag tcaatttcta cttctggaag tcatctcatt ccactgttgg tattatataa ttcaaggaga atatgataaa acactgccct cttgtggtgc attgaaagaa gagatgagaa atgatgaaaa ggttgcctga aaaaigggag acagcctctt acttgccaag aaaatgaagg gattggaccg agctggaaaa cctcctttac cagatgctga ctggcactgg tggtttttgc tctcg &lt; 210> 299 &lt; 211〉 540 &lt; 212 &gt; DNA &lt; 213> human 98677.doc 239-

200533758 &lt;220〉 &lt;223&gt; Probe 38129^at HG-U95Av2 &lt;220&gt; &lt;221&gt; mi sc一feature &lt;222〉 205·.208, 210, 238..241， 280, 281， 290, 357 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 391, 456..470, 501 籲 &lt;223〉n 為 a, g，c 或 t &lt;400〉 299 atctccagaa agtggtattc cataaaacct accaactcat ggattcccaa gatgtgagct ttttacataa tgaaagaacc cagcaattct gtctcttaat gcaatgacac tattcataga ctttgatttt atttataagc cacttgctgc atgaccctcc aagtagacct gtggcttaaa ataaagaaaa tgcagcaaaa agaannnnan agaaatattt ggtggttttt tttttttnnn naaacatcca cagttaaggt tgggccagct acctttgggn ntgacccccn ccattgccat aacatcctgc tccattccct ctaagatgta ggaagaattc ggatccttac cattggnaat cttccatcga acatactcaa acacttttgg nccaggattt gagtctctgc atgacatata cttgattaaa aggttattac taacctgtta aaaatnnnnn nnnnnnnnnn tttaacagac accctaaaag tctccttttc nacatagttg aagacagcaa catcttcact gaatgttttg200533758 &lt; 220> &lt; 223 &gt; Probe 38129 ^ at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222> 205 · .208, 210, 238..241, 280, 281, 290, 357 &lt; 223〉 n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; 391, 456..470, 501 &lt; 223> n is a, g, c or t &lt; 400> 299 atctccagaa agtggtattc cataaaacct accaactcat ggattcccaa gatgtgagct ttttacataa tgaaagaacc cagcaattct gtctcttaat gcaatgacac tattcataga ctttgatttt atttataagc cacttgctgc atgaccctcc aagtagacct gtggcttaaa ataaagaaaa tgcagcaaaa agaannnnan agaaatattt ggtggttttt tttttttnnn naaacatcca cagttaaggt tgggccagct acctttgggn ntgacccccn ccattgccat aacatcctgc tccattccct ctaagatgta ggaagaattc ggatccttac cattggnaat cttccatcga acatactcaa acacttttgg nccaggattt gagtctctgc atgacatata cttgattaaa aggttattac taacctgtta aaaatnnnnn nnnnnnnnnn tttaacagac accctaaaag tctccttttc nacatagttg aagacagcaa catcttcact gaatgttttg

&lt;210&gt; 300 &lt;211〉 301 &lt;212&gt; DNA 60 120 180 240 300 360 420 480 98677.doc - 240- 540 200533758 &lt;213&gt; 人類 &lt;220&gt; &lt;223&gt; Probe 38130_sjt HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （168)..(184) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 300 • catattgctt ttgctgcatt agaagctgtt tgtttccaaa ctcgagagat tttggatgcc atgaatcgag actgtggaat tccactcagt catttgcagg ttgatggagg aatgaccagc aacaaaattc ttatgcagct acaagcagac attctgtata ttccagtnnn nnnnnnnnnn nnnnccgaaa ccactgcact gggtgctgcc atggcggcag gggctgcaga aggagtcgac gtatggagtc ttgaacctga ggatttgtcc gccgtcacga tggagcggtt tgaacctcag a&lt; 210 &gt; 300 &lt; 211〉 301 &lt; 212 &gt; DNA 60 120 180 240 300 360 420 480 98677.doc-240- 540 200533758 &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 38130_sjt HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (168) .. (184) &lt; 223 &gt; n is a, g, c or t &lt; 400> 300 • catattgctt ttgctgcatt agaagctgtt tgtttccaaa ctcgagagat tttggatgcc atcaatgaggatcggggact aatgaccagc aacaaaattc ttatgcagct acaagcagac attctgtata ttccagtnnn nnnnnnnnnn nnnnccgaaa ccactgcact gggtgctgcc atggcggcag gggctgcaga aggagtc tggggtgt

60 120 180 240 300 30160 120 180 240 300 301

&lt;210&gt; 301 &lt;211&gt; 431 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38152^at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （130)..(145) &lt;223&gt; n 為 a，g，c 或 t 98677.doc 241 - 200533758 &lt;400〉 301 agtgctacat gttttagcag atcaacaacn ttgaatagta gatgccggtg ctgaaaattt nnnnnnnnnn agatgttaat ttgaccttcc atttctccct nnnnnttctt tttttttact ttcaagagga gtaaacgtta attctttcta ataaacattt ccaaatgatt aaaacagttt aactacaacg ttagagaagt tcagaattta tccaaataac aacacaagaa aaaacatgct&lt; 210 &gt; 301 &lt; 211 &gt; 431 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 38152 ^ at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 (130) .. (145) &lt; 223 &gt; n is a, g, c or t 98677.doc 241-200533758 &lt; 400〉 301 agtgctacat gttttagcag atcaacaacn ttgaatagta gatgccggtg ctgaaaattat ac ttgcctt ttgcctttt ccttt acc aactacaacg ttagagaagt tcagaattta tccaaataac aacacaagaa aaaacatgct

gaaaactaca caaattataa gcatacaact ggactcatta tcacagtgaa tgcactgtgt gatcgccaca taggtaaaaa ctggaatggt cgtaggcctc tccatctgta cccttttcca tcatgtccta ttccctgtca ctacacacta aaactttcct gacttacaat accatgggtt atttatgctt g &lt;210〉 302 &lt;211&gt; 618 &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 38169j__at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 35..78, 142..236, 274..346, 529..547 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 302 ggatcgtctc ccagggtaac ctcgaagagt gagtnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnct cttctgcccc tcccttctgc caacacagca gtcagcttct 98677.doc -242- 180 180gaaaactaca caaattataa gcatacaact ggactcatta tcacagtgaa tgcactgtgt gatcgccaca taggtaaaaa ctggaatggt cgtaggcctc tccatctgta cccttttcca tcatgtccta ttccctgtca ctacacacta aaactttcct gacttacaat accatgggtt atttatgctt g &lt; 210> 302 &lt; 211 &gt; 618 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 38169j__at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 35..78, 142..236, 274..346, 529..547 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 302 ggatcgtctc ccagggtaac ctcgaagagt gagtnnnnnn nnnnnnnnnn nnnnnnnnnnnn nnnnnnnnnn nnnnnnnnct cttctgcccc tcccttctgc caacacagca gtcagcttct 98677.doc -242- 180 180

200533758 ctcgtgagct ttctggtagg annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngctg tttcttgttc tcttcgttgc catcgttctc accnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngcat cttggtgaac atttacttga tggtccagtt aagtgcagac acttgggtca gattcagcat ttggatggca attggcttcc tgatttactt ttcttatggc attagacaca gcctggaggg tcatctgaga • gatgaaaaca atgaagaaga tgcttatcca gacaacgttc atgcageann nnnnnnnnnn nnnnnnnttc aagcaaatga ccatcaccca agaaatetea gttcaccttt catattccat gaaaagacaa gtgaattc &lt;210〉 303 &lt;211&gt; 601 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 38177—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 110， 117..123， 126， 127， 129， 130， 132..139， 141， 143..147 &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; 218..264, 308, 433, 442, 541..573 &lt;223〉n 為 a，g，c 或 t 240 300 360 420 480 540 600 618 98677.doc -243 - 60 200533758 &lt;400〉 303 ggcgctgtcc tgaatcccca cgaggccctg gctcagcctc ttcccaccac aggcacacca gggtcagaag gggggacggt gaagaactat gagacagctg tccaattttn ctggaannnn nnnaannann annnnnnnnc nannnnnaag gattggtgcg actgggccat gattagcagg ccttatagca ccctgcgaga ttgcctggag cactttgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnatcttt gagactcacc agatccactt tgccaactgc tccctggntg cagcccacct tctctgaccc cccagaggat gtactcctgg ccatgatcat200533758 ctcgtgagct ttctggtagg annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngctg tttcttgttc tcttcgttgc catcgttctc accnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngcat cttggtgaac atttacttga tggtccagtt aagtgcagac acttgggtca gattcagcat ttggatggca attggcttcc tgatttactt ttcttatggc attagacaca gcctggaggg tcatctgaga • gatgaaaaca atgaagaaga tgcttatcca gacaacgttc atgcageann nnnnnnnnnn nnnnnnnttc aagcaaatga ccatcaccca agaaatetea gttcaccttt catattccat gaaaagacaa gtgaattc &lt; 210〉 303 &lt; 211 &gt; 601 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 38177-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 110, 117..123, 126, 127, 129, 130, 132..139, 141, 143..147 &lt; 223 &gt; n is a, g, c or t &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 218..264, 308, 433, 442, 541..573 &lt; 223〉 n is a, g, c or t 240 300 360 420 480 540 600 618 98677.doc -243-60 200 533758 &lt; 400> 303 ggcgctgtcc tgaatcccca cgaggccctg gctcagcctc ttcccaccac aggcacacca gggtcagaag gggggacggt gaagaactat gagacagctg tccaattttn ctggaannnn nnnaannann annnnnnnnc nannnnnaag gattggtgcg actgggccat gattagcagg ccttatagca ccctgcgaga ttgcctggag cactttgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnatcttt gagactcacc agatccactt tgccaactgc tccctggntg cagcccacct tctctgaccc cccagaggat gtactcctgg ccatgatcat

agcccccatc tgcctcatcc ccttcctcat cactcttgta gtatggagga gtaaagacag tgaggcccag gcntaggggg cnacgagctt ctcaacaacc atgttactcc acttccccac ccccaccagg cctccctcct cccctcctac tcccttttct cactctcatc cccaccacag nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnggtcatg gcacaagttc tgtaatcttc &lt;210〉 304 W &lt;211&gt; 380 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 38222_at HG-U95Av2 120 180 240 300 360 420 480 540 600 601 &lt;400〉 304 cacccagaag gcagaggcag ccggggcacc aagttccgcc ggtcgctgag aggagcccca ggcgaccaca tcctccaggt ccaaccccaa tgagctccta cctgggcagc accatgcgga cagaaactca cttcatattt gaattagagt cagccaaatg gccattgtgt tcagctcagc 60 120 180 98677.doc -244- 200533758 tgggcatgga ccccttctct agaggtccca agtgtgacgt gttaagatcc ggcccagacc gtcagccatg gtactgtcaa ctcacaggac ctgtgggcat gagagctggg ccagaagctc ggagatggac gaaaccacat accaaaaact agacctgggc taaggtgctc atttcttcag ctggctcttg acaaaaatac 240 300 360 380 &lt;210&gt; 305 &lt;211〉 566 φ &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223〉 Probe 38223—at HG-U95Av2 &lt;220&gt; &lt;221〉 misc_feature &lt;222&gt; 26, 67, 81， 86, 98..112, 265·.301， 541 &lt;223〉n 為 a，g，c 或 tagcccccatc tgcctcatcc ccttcctcat cactcttgta gtatggagga gtaaagacag tgaggcccag gcntaggggg cnacgagctt ctcaacaacc atgttactcc acttccccac ccccaccagg cctccctcct cccctcctac tcccttttct cactctcatc cccaccacag nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnggtcatg gcacaagttc tgtaatcttc &lt; 210> 304 W &lt; 211 &gt; 380 &lt; 212> DNA &lt; 213> Human &lt; 220 &gt; &lt; 223 &gt; Probe 38222_at HG-U95Av2 120 180 240 300 360 420 480 540 600 601 &lt; 400> 304 cacccagaag gcagaggcag ccggggcacc aagttccgcc ggtcgctgag aggagcccca ggcgaccaca tcctccaggt ccaaccccaa tgagctccta cctgggcagc accatgcgga cagaaactca cttcatattt gaattagagt cagccaaatg gccattgtgt tcagctcagc 60 120 180 98677.doc -244- 200533758 tgggcatgga ccccttctct agaggtccca agtgtgacgt gttaagatcc ggcccagacc gtcagccatg gtactgtcaa ctcacaggac ctgtgggcat gagagctggg ccagaagctc ggagatggac gaaaccacat accaaaaact agacctgggc taaggtgctc atttcttcag ctggctcttg acaaaaatac 240 300 360 380 &lt; 210 &gt; 305 &lt; 211> 566 φ &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Prob e 38223-at HG-U95Av2 &lt; 220 &gt; &lt; 221〉 misc_feature &lt; 222 &gt; 26, 67, 81, 86, 98..112, 265 · .301, 541 &lt; 223> n is a, g, c Or t

&lt;400&gt; 305 gcaagacagc tttcttnggg taaacaacct ttgagaattg taccggattt ngaacacaat ttggagtgac agctgctatg gtcagcccta gacaaactgt tcagtgccct gctgaaatgg gtctcatact aatgggagag cacacntgga naccgngatt ggccagggga aaggtatcca gcacnnnnnn aaccaagaag gtcaggaatc gtccaccata tcagtctnnn accgacacaa ttggttccct nnnnnnnnnn caagaaaagc aagttcactt ccaaagcacg nnnnnnnnnn ccctcaagca tgatgccaac nnnnnnnnnn cccatgcttt tcaagatcta aaccagactg nncatctggc tttctatgta ttacaatttt nnnnnnnnnn catttttcac agggagtcca 60 120 180 240 300 360 420 98677.doc - 245 - 200533758 ctatctgtgc aattgtattt ggcttttttt tgcactgttt caatgctggt aattgaaacc 480 attttaatat atttggttgt attcacttta tatgtccttc caaaaatgtt gttgtgtaca 540 naccatgctt tcaatgttgg cttcca 566 &lt;210〉 306 &lt;211&gt; 365 &lt;212&gt; DNA &lt;213&gt;人類&Lt; 400 &gt; 305 gcaagacagc tttcttnggg taaacaacct ttgagaattg taccggattt ngaacacaat ttggagtgac agctgctatg gtcagcccta gacaaactgt tcagtgccct gctgaaatgg gtctcatact aatgggagag cacacntgga naccgngatt ggccagggga aaggtatcca gcacnnnnnn aaccaagaag gtcaggaatc gtccaccata tcagtctnnn accgacacaa ttggttccct nnnnnnnnnn caagaaaagc aagttcactt ccaaagcacg nnnnnnnnnn ccctcaagca tgatgccaac nnnnnnnnnn cccatgcttt tcaagatcta aaccagactg nncatctggc tttctatgta ttacaatttt nnnnnnnnnn catttttcac agggagtcca 60 120 180 240 300 360 420 98677.doc-245-200533758 ctatctgtgc aattgtattt ggcttttttt tgcactgttt caatgctggt aattgaaacc 480 attttaatat atttggttgt attcacttta tatgtccttc ca & aa &212; 212 &gt; 210 &gt; 210 &lt; gtgttgttgtgttttgtgttttgtgttttgttgt

&lt;220&gt; &lt;223&gt; Probe 38234—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （191)..(191) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 306 cagccgagcg ttcagggctg cgctccggcc ggctgagagg gcacgtgccc cgtcacagtc 60&lt; 220 &gt; &lt; 223 &gt; Probe 38234—at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (191) .. (191) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 306 cagccgagcg ttcagggctg cgctccggcc ggctgagagg gcacgtgccc cgtcacagtc 60

tggactcctg ggcctggatt gatgtgtctc acagactcgg aagggttctg ctcctcctcc 120 tccccctgaa caatgctggc agttgctaca aatagattta ttggaggctt atggctccgg 180 ttcccccaca nacccgctca tgagtctctg tttgttcttc ccttttcttt tgccctgtcc 240 ctcaccttgg gtcgggggtg ctggagtgga ccacaatgtt gtgctggggg atgggggggt 300 ctctctttgc cgattgtgca gtgcacaaga tttgtgaaaa atgtaaataa cagactccta 360 ttgcg 365 98677.doc - 246 - 200533758 &lt;210&gt; 307 &lt;211〉 540 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 38247一at HG-U95Av2 &lt;220&gt; &lt;221〉mi sc一feature &lt;222〉 （452)..(467) &lt;223&gt; n 為 a，g, c 或 t &lt;400〉 307 cagactggga acagggccca ggaatctgtg tggtacaaac ctgcatggtg tttatgcaca 60 cagagatttg agaaccattg ttctgaatgc tgcttccatt tgacaaagtg ccgtgataat 120 ttttgaaaag agaagcaaac aatggtgtct cttttatgtt cagcttataa tgaaatctgt 180 ttgttgactt attaggactt tgaattattt ctttattaac cctctgagtt tttgtatgta 240 ttattattaa agaaaaatgc aatcaggatt ttaaacatgt aaatacaaat tttgtataac 300 ttttgatgac ttcagtgaaa ttttcaggta gtctgagtaa tagattgttt tgccacttag 360 aatagcattt gccacttagt attttaaaaa ataattgttg gagtatttat tgtcagtttt 420 gttcacttgt tatctaatac aaaattataa annnnnnnnn nnnnnnngac cacatctctt 480 tggaaaatag tttgcaacat atttaagaga tacttgatgc caaaatgact ttatacaacg 540tggactcctg ggcctggatt gatgtgtctc acagactcgg aagggttctg ctcctcctcc 120 tccccctgaa caatgctggc agttgctaca aatagattta ttggaggctt atggctccgg 180 ttcccccaca nacccgctca tgagtctctg tttgttcttc ccttttcttt tgccctgtcc 240 ctcaccttgg gtcgggggtg ctggagtgga ccacaatgtt gtgctggggg atgggggggt 300 ctctctttgc cgattgtgca gtgcacaaga tttgtgaaaa atgtaaataa cagactccta 360 ttgcg 365 98677.doc - 246 - 200533758 &lt; 210 &gt; 307 &lt; 211〉 540 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223〉 Probe 38247-at HG-U95Av2 &lt; 220 &gt; &lt; 221〉 mi sc-feature &lt; 222> (452) .. (467) &lt; 223 &gt; n is a, g, c or t &lt; 400> 307 cagactggga acagggccca ggaatctgtg tggtacaaac ctgcatggtg tttatgcaca 60 cagagatttg agaaccattg ttctgaatgc tgcttccatt tgacaaagtg ccgtgataat 120 ttttgaaaag agaagcaaac aatggtgtct cttttatgtt cagcttataa tgaaatctgt 180 ttgttgactt attaggactt tgaattattt ctttattaac cctctgagtt tttgtatgta 240 ttattattaa agaaaaatgc aatcaggatt ttaaacatgt aaatacaaat tttgtataac 300 ttttgatgac ttcagtgaaa ttttcaggta gtctgagtaa tagattgttt tgccacttag 360 aatagcattt gccacttagt attttaaaaa ataattgttg gagtatttat tgtcagtttt 420 gttcacttgt tatctaatac aaaattataa annnnnnnnnnn nnnnnnngac cacatctctt 480 tggaaaatag tttgactca tca

&lt;210&gt; 308 &lt;211&gt; 588 &lt;212〉 DNA &lt;213&gt;人類 98077.doc -247 -&lt; 210 &gt; 308 &lt; 211 &gt; 588 &lt; 212> DNA &lt; 213 &gt; human 98077.doc -247-

200533758 &lt;220&gt; &lt;223&gt; Probe 38267eat HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 282, 400·.402, 405..407, 409, 410, 413, 488..538 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 308 gttctaacta gtaatcttgg ccctattcat tacatcctct gcttgtcatt ctgctaattt atgaagatag tttattatag tctgtacttc agttctcatc ttgtaaataa tgcttaacat aaacttgtac ttacactgaa atccaaaata gtcatgtttc tgcagtattc tgtagccaac ttaaacctgt gctttcatgt ttaagaaatg agaaattgtg ccaaagatag cagaagagta gataagtgct cagtattgac gacctacatc tgaaatctac ancataatga tactgaattg ttatgtaaac atcataaata gtaaataatg attcaatgtg aattttaaaa tgcaaatatt gctattgttt ataggaaata aatctaaata taaatgaaan nnaannnann aantttatct tgggctaaat ggttctaccc cttactaggt tgccccaatt agtggcacta gttggcagag ctgttcannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnac tgctgttaac tcataaaaga gaagagtgtt ccatttcagt ctcaataa &lt;210&gt; 309 &lt;211〉 499 &lt;212&gt; DNA &lt;213〉人類 &lt;22〇&gt; 60 120 180 240 300 360 420 480 540 588 98677.doc -248 - 200533758 &lt;223&gt; Probe 38268_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 106..141， 215, 221， 223, 226, 229, 235, 238, 250, 351 &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc^feature &lt;222&gt; 352, 376..408, 453, 474 &lt;223&gt; n 為 a, g，c 或 t200533758 &lt; 220 &gt; &lt; 223 &gt; Probe 38267eat HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 282, 400 · .402, 405..407, 409, 410, 413, 488..538 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 308 gttctaacta gtaatcttgg ccctattcat tacatcctct gcttgtcatt ctgctaattt atgaagatag tttattatag tctgtacttc agttctcatc ttgtaaataa tgcttaacat aaacttgtac ttacactgaa atccaaaata gtcatgtttc tgcagtattc tgtagccaac ttaaacctgt gctttcatgt ttaagaaatg agaaattgtg ccaaagatag cagaagagta gataagtgct cagtattgac gacctacatc tgaaatctac ancataatga tactgaattg ttatgtaaac atcataaata gtaaataatg attcaatgtg aattttaaaa tgcaaatatt gctattgttt ataggaaata aatctaaata taaatgaaan nnaannnann aantttatct tgggctaaat ggttctaccc cttactaggt tgccccaatt agtggcacta gttggcagag ctgttcannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnac tgctgttaac tcataaaaga gaagagtgtt ccatttcagt ctcaataa &lt; 210 &gt; 309 &lt; 211> 499 &lt; 212 &gt; DNA &lt; 213> human &lt; 22〇 &gt; 60 120 180 240 300 360 420 480 540 588 98677.doc -248-200533758 &lt; 223 &gt; Probe 38268_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 106..141, 215, 221, 223, 226, 229, 235, 238, 250, 351 &lt; 223 &gt; n is a , G, c or t &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 352, 376..408, 453, 474 &lt; 223 &gt; n is a, g, c or t

&lt;400&gt; 309 ctcatgcata gacaagtgtt ttgggttttt aaaaaaaata ttctgtcatt ggttacaaat ttttactcag gctttctatt ggcatggatt tcctttgacc tctcannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nccccagtta atgtgccaaa atgtcaattt ttaacttatc tccagccaat ttcaaagaaa acagaccagc atagnttctg ncnatnacng ttttnagntg ggcatagggn ttggaagaaa gggagaagga ttcttttttc aatgtactgt attgggacgc&Lt; 400 &gt; 309 ctcatgcata gacaagtgtt ttgggttttt aaaaaaaata ttctgtcatt ggttacaaat ttttactcag gctttctatt ggcatggatt tcctttgacc tctcannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nccccagtta atgtgccaaa atgtcaattt ttaacttatc tccagccaat ttcaaagaaa acagaccagc atagnttctg ncnatnacng ttttnagntg ggcatagggn ttggaagaaa gggagaagga ttcttttttc aatgtactgt attgggacgc

tggtaactgt ttattatttt agagttctcc taacccagtg catatnnnnn ttgtacttga ttcagcatag nnnnnnnnnn ataataacca agctatatat nnnnnnnnnn cgnttccaac atatatatat nnnnnnnnaa ccaggtctgc nngtatatat tgtgaaataa tttngggctt atcagaactc ctttctaag &lt;210〉 310 &lt;211&gt; 435 &lt;212&gt; DNA &lt;213〉 人類 98677.doc 249-tggtaactgt ttattatttt agagttctcc taacccagtg catatnnnnn ttgtacttga ttcagcatag nnnnnnnnnn ataataacca agctatatat nnnnnnnnnn cgnttccaac atatatatat nnnnnnnnaa ccaggtctgc nngtatatat tgtgaaataa tttngggctt atcagaactc ctttctaag &lt; 210> 310 &lt; 211 &gt; 435 &lt; 212 &gt; DNA &lt; 213> human 98677.doc 249-

200533758 &lt;220&gt; &lt;223&gt; Probe 38276—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （247)..(283) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 310 ccggagccat aactgctgca gtttgggccc aggciatgtg ctcttctggt gccctaggga ctgctgtggc cagagcctgg ggccagccag tacagtcctg agccgaggag gagggactgc aagtggaaga gagccagtct ggaaggaaga gctttccagg tggacagggc ttcttggaag acccccaaag ccccaggtat cctgggtgaa gcctgtttgc ctctcttgaa aatggcaggt gctcttnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnagtagga agcatggact ctcctgagtg agaagagact gaaataggag caagcagaac cctgagaggt gtcccatctt attgctgttg aggaccctga aacaccgttg tttaaagact tcacacagaa ggctctgaac tgagccactg gggaa200533758 &lt; 220 &gt; &lt; 223 &gt; Probe 38276-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (247): (283) &lt; 223 &gt; n is a, g, c or t &lt; 400> 310 ccggagccat aactgctgca gtttgggccc aggciatgtg ctcttctggt gccctaggga ctgctgtggc cagagcctgg ggccagccag tacagtcctg agccgaggag gagggactgc aagtggaaga gagccagtct ggaaggaaga gctttccagg tggacagggc ttcttggaag acccccaaag ccccaggtat cctgggtgaa gcctgtttgc ctctcttgaa aatggcaggt gctcttnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnagtagga agcatggact ctcctgagtg agaagagact gaaataggag caagcagaac cctgagaggt gtcccatctt attgctgttg aggaccctga aacaccgttg tttaaagact tcacacagaa ggctctgaac tgagccactg gggaa

&lt;210〉 311 &lt;211〉 294 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 38278—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; (51)..(65) 60 120 180 240 300 360 420 435 98677.doc - 250 - 200533758 &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （116)..(116) &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; &lt;222〉 &lt;223〉&lt; 210〉 311 &lt; 211〉 294 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220〉 &lt; 223 &gt; Probe 38278-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; (51 ) .. (65) 60 120 180 240 300 360 420 435 98677.doc-250-200533758 &lt; 223 &gt; η is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (116) .. (116) &lt; 223 &gt; η is a, g, c or t &lt; 220〉 &lt; 221 &gt; &lt; 222〉 &lt; 223〉

misc一feature (240)..(240) n 為 a，g，c 或 t &lt;400〉 311 gtaggccagc ccatggtgtt nnnnnctgcc agggggctct tggctgggca gcctggcaca ggcagcagcc tgagcccagg ggcagctccc actgccccag gtgtacactg tggagtcgac gaactagtgc ctgctaccca agtgaagaag aaggcagtgg agcagaggac ccagttgtta agcggagctc gaagcaccca aggggcctac nnnnnnnnnn ggacacccgg gccatncccc gaaaactggg tttatctcaa taaggcgctg ggagaggatn ggttgcccac ggaa 60 120 180 240 294misc a feature (240) .. (240) n is a, g, c or t &lt; 400> 311 gtaggccagc ccatggtgtt nnnnnctgcc agggggctct tggctgggca gcctggcaca ggcagcagcc tgagcccagg ggcagctccc actgccccag gtgtacactg tggagtcgac gaactagtgc ctgctaccca agtgaagaag aaggcagtgg agcagaggac ccagttgtta agcggagctc gaagcaccca aggggcctac nnnnnnnnnn ggacacccgg gccatncccc gaaaactggg tttatctcaa taaggcgctg ggagaggatn ggttgcccac ggaa 60 120 180 240 294

&lt;210&gt; 312 &lt;211〉 444 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38287__at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (327)..(342) 9S6^7.doc -251 -&lt; 210 &gt; 312 &lt; 211> 444 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 38287__at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (327). . (342) 9S6 ^ 7.doc -251-

200533758 &lt;223〉η 為 a,g，c 或 t &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 （362)..(381) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 312 actggaggaa cctccacttg ttttggctgc tgcaaatgtg gtgagaaata tcagctataa atatcgagag gacttgtctg cacatctcat ggtagctggc tgggaccaac gtgaaggagg tcaggtatat ggaaccctgg gaggaatgct gactcgacag ccttttgcca ttggtggctc cggcagcacc tttatctatg gttatgtgga tgcagcatat aagccaggca tgtctcccga ggagtgcagg cgcttcacca cagacgctat tgctctggcc atgagccggg atggctcaag cgggggtgtc atctacctgg tcactannnn nnnnnnnnnn nnggaccatc gagtcatctt gnnnnnnnnn nnnnnnnnnn nctatgatga gtgaaccttc cccagacttc tctttcttat tttgtaataa actctctagg gcca 60 120 180 240 300 360 420 444200533758 &lt; 223〉 η is a, g, c or t &lt; 220〉 &lt; 221 &gt; mi sc-feature &lt; 222〉 (362) .. (381) &lt; 223 &gt; n is a, g, c or t &lt; 400> 312 actggaggaa cctccacttg ttttggctgc tgcaaatgtg gtgagaaata tcagctataa atatcgagag gacttgtctg cacatctcat ggtagctggc tgggaccaac gtgaaggagg tcaggtatat ggaaccctgg gaggaatgct gactcgacag ccttttgcca ttggtggctc cggcagcacc tttatctatg gttatgtgga tgcagcatat aagccaggca tgtctcccga ggagtgcagg cgcttcacca cagacgctat tgctctggcc atgagccggg atggctcaag cgggggtgtc atctacctgg tcactannnn tttgtaataa actctctagg nnnnnnnnnn nnggaccatc gagtcatctt gnnnnnnnnn nnnnnnnnnn nctatgatga gtgaaccttc cccagacttc tctttcttat gcca 60 120 180 240 300 360 420 444

&lt;210〉 313 &lt;211&gt; 594 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38298_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; 39, 44, 264..296, 417..431, 524, 525, 537..569 98677.doc 60 60&lt; 210> 313 &lt; 211 &gt; 594 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 38298_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 39, 44, 264..296, 417..431, 524, 525, 537..569 98677.doc 60 60

200533758 &lt;223〉η 為 a，g，c 或 t &lt;400&gt; 313 ataccacttg tcagggcaca ggggactggc tgggccccna gggntgctcc ccacttgcag cacaatgcct tctccacctg ccctcccact cttccagtcc aatccacgct gtcttctgtt gcaggactaa cctttgagaa atccttttgt gaagtcattg cctgctcaag aatgtacagt ggctcccxaa tgccttggag gccataaggc cagccagttc tagctctcta ttacctgtcc ccactcaact gactcatacc tgtnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncgat gatcgtcacc tctgtgcctg agttctccct gttgtctcaa agcggtaccc atcctccccc agaagctgtc cccagcgagc ctcccttctt tgtttgaatt ctctaataag agcaacnnnn nnnnnnnnnn ntagaacaca tttacagtat tactattttc taggatataa agtgccatat atatttttaa ttccaatatt aataaatgta tgccaaacaa caannaaaaa aaaaaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc agctgcaagg aaacacatga gaac φ &lt;210&gt; 314 &lt;211&gt; 325 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223&gt; Probe 38299_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （202)..(222) &lt;223&gt; n 為 a，g，c 或 t 120 180 240 300 360 420 480 540 594 98677.doc -253 - 60 200533758 &lt;400〉 314 tgggcacctc agattgttgt ctgggcacag aacttatgtt attttaatta tttttaattt gtcatattta tatttttaag ataatggaaa gtggctatgc gaaagtgtag gcttacctca tgttaatggg cattccttct gttctctatg gagaactaaa attaatattt aaatatgtga annnnnnnnn nnnnnnnnnn agtttgaata tcctttgttt aataa tctggtcaga aacctgtcca agtatgagcg ttaggacact agctgagtta atttatgtaa nntgtattag ttttgaaata cagagccaga tcatttcttg 120 180 240 300 325 &lt;210〉 315 &lt;211〉 564 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 38315—at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature φ &lt;222〉 （213)..(213) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （170)..(170) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; (417)..(469) 98677.doc -254 - 60 60200533758 &lt; 223> η is a, g, c or t &lt; 400 &gt; 313 ataccacttg tcagggcaca ggggactggc tgggccccna gggntgctcc ccacttgcag cacaatgcct tctccacctg ccctcccact cttccagtcc aatccacgct gtcttctgtt gcaggactaa cctttgagaa atccttttgt gaagtcattg cctgctcaag aatgtacagt ggctcccxaa tgccttggag gccataaggc cagccagttc tagctctcta ttacctgtcc ccactcaact gactcatacc tgtnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncgat gatcgtcacc tctgtgcctg agttctccct gttgtctcaa agcggtaccc atcctccccc agaagctgtc cccagcgagc ctcccttctt tgtttgaatt ctctaataag agcaacnnnn nnnnnnnnnn ntagaacaca tttacagtat tactattttc taggatataa agtgccatat atatttttaa ttccaatatt aataaatgta tgccaaacaa caannaaaaa aaaaaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc agctgcaagg aaacacatga gaac φ &lt; 210 &gt; 314 &lt; 211 &gt; 325 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 38299_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 (202) .. (222) &lt; 223 &gt; n is a, g, c or t 120 180 240 300 360 420 480 540 594 98677.doc -253-60 200533758 &lt; 400 > 314 tgggcacctc agattgttgt ctgggcacag aacttatgtt attttaatta tttttaattt gtcatattta tatttttaag ataatggaaa gtggctatgc gaaagtgtag gcttacctca tgttaatggg cattccttct gttctctatg gagaactaaa attaatattt aaatatgtga annnnnnnnn nnnnnnnnnn agtttgaata tcctttgttt aataa tctggtcaga aacctgtcca agtatgagcg ttaggacact agctgagtta atttatgtaa nntgtattag ttttgaaata cagagccaga tcatttcttg 120 180 240 300 325 &lt; 210> 315 &lt; 211> 564 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223〉 Probe 38315-at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature φ &lt; 222〉 (213) .. (213) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (170) .. (170) &lt; 223> n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; (417) .. (469) 98677.doc -254-60 60

200533758 &lt;223〉η 為 a，g，c 或 t &lt;400〉 315 agcttgcagg gagtaaagca ggcccgcctc cctttcttcc catccacata ctcctcttct gctttccagt gactccacca gtttgatgtg ggaagtgtta gcttcctttc cttcttccat cccttcttcc atctttccag ctgtcaaatc caatccagtc tctaacctan atgcagatca tttatttaaa agtaccaaac ataacccaga gtntgtggaa tatgggcaac atatatatag ccttctgtat ttaacgatct tctgcttctt aaccgtacca gttttctatt tataactctt atctatccat gatgttttaa agtctccact tgctgttatt tacaaacgac agtgcattca gcagcccagt gccgtgagcc ctgacagatg ccgtatttct gagtgcttcc atgtgannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt tacctttgga ctgcaacaaa aaatgtgaaa atgaagattt atttctttta atttacttaa aaagaaacct ctgtgctagc aataaagcat ttat φ &lt;210&gt; 316 &lt;211&gt; 399 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 38326.at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （320)..(320) &lt;223&gt; n 為 a，g，c 或 t 120 180 240 300 360 420 480 540 564 98677.doc -255 - 200533758 &lt;400〉 316200533758 &lt; 223> η is a, g, c or t &lt; 400> 315 agcttgcagg gagtaaagca ggcccgcctc cctttcttcc catccacata ctcctcttct gctttccagt gactccacca gtttgatgtg ggaagtgtta gcttcctttc cttcttccat cccttcttcc atctttccag ctgtcaaatc caatccagtc tctaacctan atgcagatca tttatttaaa agtaccaaac ataacccaga gtntgtggaa tatgggcaac atatatatag ccttctgtat ttaacgatct tctgcttctt aaccgtacca gttttctatt tataactctt atctatccat gatgttttaa agtctccact tgctgttatt tacaaacgac agtgcattca gcagcccagt gccgtgagcc ctgacagatg ccgtatttct gagtgcttcc atgtgannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt tacctttgga ctgcaacaaa aaatgtgaaa atgaagattt atttctttta atttacttaa aaagaaacct ctgtgctagc aataaagcat ttat φ &lt; 210 &gt; 316 &lt; 211 &gt; 399 &lt; 212> DNA &lt; 213> human &lt; 220 &gt; &lt; 223 &gt; Probe 38326.at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (320) .. (320) &lt; 223 &gt; n is a, g, c or t 120 180 240 300 360 420 480 540 564 98677.doc -255-200533758 &lt; 400〉 316

gacaggctct ccagaagcaa gccctgcagg agaaaggcaa gcagcaggac acggtcctcg gcggccgggc cctgtccaac cggcagcacg cctcctagga actgtgggag accagcggag tgggagggag acgcagtaga cagagacaga ccgagaagga agggagagac agagggggcg cgcgcacagg agcctgactc cgctgggaga gtgcaggagc acgtgctgtt ttttatttgg acttaacttc agagaaaccg ctgacatcta gaactgacct accacaagca tccaccaaag gagtttggga ttgagttttn ctgctgtgca gcactgcatt gtcatgacat ttccaacact gtgtgaatta tctaaatgcg tctaccattt tgcactagg &lt;210〉 317 &lt;211〉 570 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 38332一at HG-U95Av2 φ &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 296, 330..344, 439..519 &lt;223〉n 為 a，g，c 或 t &lt;400〉 317 cagggtcttg cccatcaaag tttctggaat ctagtgagct aacagagagg ctgattgagt ggaccagtga aggaggaggg ctccactcca ggcctacccc agaaatggcc caagcactca acacctgggc accacatcac gggttcccca tctccacagc cccagagaaa gcagctcctg 98677.doc -256 - 240 200533758 tgtgttgtgt gcaggatctg ctgggtcaac tctgcttttc agtggcactg ctgtggcttt agctctctcc aggacaggcc gcggcagggg aggccgccnn nnnnnnnnnn nnnnnnnnnn ctgtgctaag gtgatcgagg tttgcccact cggcccagga ccgcaacctg gggttgtcgg cagggctggn nnnnnnnnnn cagtcctctg aggcacggcg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng accagacatt ggtcagcagt ctgttcttgg gggagcgctg gcccgnacgc nnnngaagcc tcctgtctcc gctctgttca agcactttat nnnnnnnnnn nnnnnnnnnn catttcicct cagagaagcg 300 360 420 480 540 570 &lt;210&gt; 318 &lt;211&gt; 443 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38430^at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature φ &lt;222&gt; 35..58, 72, 78·.80, 82, 83, 85, 147, 218, 224 &lt;223〉n 為 a，g，c 或 t &lt;400〉 318 60 120 180 gatgcttttg taggtacctg gaaacttgtc tccannnnnn nnnnnnnnnn nnnnnnnnaa gaagtaggag tnggcttnnn cnncnaggaa agtggctggc atggccaaac ctaacatgat catcagtgtg aatggggatg tgatcancca ttaaatctga aagtaccttt aaaaatactg agatttcctt catactgggc caggaatttg acgaagtnca ctgncagatg acaggaaagt 98677.doc - 257 - 240 300 300gacaggctct ccagaagcaa gccctgcagg agaaaggcaa gcagcaggac acggtcctcg gcggccgggc cctgtccaac cggcagcacg cctcctagga actgtgggag accagcggag tgggagggag acgcagtaga cagagacaga ccgagaagga agggagagac agagggggcg cgcgcacagg agcctgactc cgctgggaga gtgcaggagc acgtgctgtt ttttatttgg acttaacttc agagaaaccg ctgacatcta gaactgacct accacaagca tccaccaaag gagtttggga ttgagttttn ctgctgtgca gcactgcatt gtcatgacat ttccaacact gtgtgaatta tctaaatgcg tctaccattt tgcactagg &lt; 210> 317 &lt; 211> 570 &lt; 212> DNA &lt; 213> Human &lt; 220 &gt; &lt; 223 &gt; Probe 38332-at HG-U95Av2 φ &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 296, 330..344, 439..519 &lt; 223> n is a, g, c or t &lt; 400> 317 cagggtcttg cccatcaaag tttctggaat ctagtgagct aacagagagg ctgattgagt ggaccagtga aggaggaggg ctccactcca ggcctacccc agaaatggcc caagcactca acacctgggc accacatcac gggttcccca tctccacagc cccagagaaa gcagctcctg 98677.doc -256 - 240 200533758 tgtgttgtgt gcaggatctg ctgggtcaac tctgcttttc agtggcactg ctgtggcttt agctctctcc aggacaggcc gcggcagg gg aggccgccnn nnnnnnnnnn nnnnnnnnnn ctgtgctaag gtgatcgagg tttgcccact cggcccagga ccgcaacctg gggttgtcgg cagggctggn nnnnnnnnnn cagtcctctg aggcacggcg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng accagacatt ggtcagcagt ctgttcttgg gggagcgctg gcccgnacgc nnnngaagcc tcctgtctcc gctctgttca agcactttat nnnnnnnnnn nnnnnnnnnn catttcicct cagagaagcg 300 360 420 480 540 570 &lt; 210 &gt; 318 &lt; 211 &gt; 443 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 38430 ^ at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature φ &lt; 222 &gt; 35..58, 72, 78 · .80, 82, 83, 85, 147, 218, 224 &lt; 223> n is a, g, c or t &lt; 400> 318 60 120 180 gatgcttttg taggtacctg gaaacttgtc tccannnnnn nnnnnnnnnn nnnnnnnnaa gaagtaggag tnggcttnnn cnncnaggaa agtggctggc atggccaaac ctaacatgat catcagtgtg aatggggatg tgatcancca ttaaatctga aagtaccttt aaaaatactg agatttcctt catactgggc caggaatttg acgaagtnca ctgncagatg acaggaaagt 98677.doc-257-240 300 300

200533758 caagagcacc ataaccttag atgggggtgt cctggtacat gtgcagaaat gggatggaaa atcaaccacc ataaagagaa aacgagagga tgataaactg gtggtggaat gcgtcatgaa aggcgtcact tccacgagag tttatgagag agcataagcc aagggacgtt gacctggact gaagttcgca ttgaactcta caa &lt;210&gt; 319 &lt;211&gt; 518 &lt;212〉 DNA φ &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38433jt HG-U95Av2 &lt;220&gt; &lt;221〉 misc一feature &lt;222〉 116， 133， 179, 235, 246, 374 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 319 tgtttcaagg cactctagat tccattggtc caagattccg gatcctaagc atctaagtta taagactctc acactcagtt gtgactaact agacaccaaa gttctaataa tttctnaatg ttggacacct ttnaggttct ttgctgcatt ctgcctctct aggaccatgg ttaagagtnc caagaatcca catttctaaa atcttatagt tctaggcact gtagttctaa gactncaaat gttctnaagt ttctaagatt ctaaaggtcc acaggtctag actattaggt gcaatttcaa ggttctaacc ctatactgta gtattctttg gggtgcccct ctccttctta gctatcattg cttcctcctc cccnaactgt gggggtgtgc ccccttcaag cctgtgcaat gcattaggga 360 420 443 60 120 180 240 300 360 98677.doc - 258 - 420 200533758 tgcctccttt cccgcagggg atggacgatc tcccaccttt cgggccatgt tgcccccgtg agccaatccc tcaccttctg agtacagagt gtggactc 480 518 &lt;210&gt; 320 &lt;211&gt; 366 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 38438—at HG-U95Av2200533758 caagagcacc ataaccttag atgggggtgt cctggtacat gtgcagaaat gggatggaaa atcaaccacc ataaagagaa aacgagagga tgataaactg gtggtggaat gcgtcatgaa aggcgtcact tccacgagag tttatgagag agcataagcc aagggacgtt gacctggact gaagttcgca ttgaactcta caa &lt; 210 &gt; 319 &lt; 211 &gt; 518 &lt; 212> DNA φ &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 38433jt HG-U95Av2 &lt; 220 &gt; &lt; 221〉 misc-feature &lt; 222〉 116, 133, 179, 235, 246, 374 &lt; 223 &gt; n is a, g, c or t &lt; 400> 319 tgtttcaagg cactctagat tccattggtc caagattccg gatcctaagc atctaagtta taagactctc acactcagtt gtgactaact agacaccaaa gttctaataa tttctnaatg ttggacacct ttnaggttct ttgctgcatt ctgcctctct aggaccatgg ttaagagtnc caagaatcca catttctaaa atcttatagt tctaggcact gtagttctaa gactncaaat gttctnaagt ttctaagatt ctaaaggtcc acaggtctag actattaggt gcaatttcaa ggttctaacc ctatactgta gtattctttg gggtgcccct ctccttctta gctatcattg cttcctcctc cccnaactgt gggggtgtgc ccccttcaag cctgtgcaat gcattaggga 360 420 443 60 120 180 240 300 360 98677.doc-258-420 2 00533758 tgcctccttt cccgcagggg atggacgatc tcccaccttt cgggccatgt tgcccccgtg agccaatccc tcaccttctg agtacagagt gtggactc 480 518 &lt; 210 &gt; 320 &lt; 211 &gt; 366 &lt; 212> Probe &gt; 213 &gt; 213 &lt; 213 &gt;

&lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （103)..(164) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (166)..(166) &lt;223&gt; n 為 a，g，c 或 t φ &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （176)..(203) &lt;223〉n 為 a，g，c 或 t &lt;400〉 320 60 120 aggtgctcag agagccggcc cgcctgaatc attctcgatt taactcgaga ccttttcaac ttggcttcct ttcttggttc ataaatgaat tttagtttgg ttnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnntngctt actaannnnn 98677.doc -259 - 180 200533758 nnnnnnnnnn nnnnnnnnnn nnntgctttc tgttgtcatt gctgttgtcc ctctgctacg 240 ttcctattgt cattaaaggt atcacggtcg ccacctggca ttccttctga ccacagcatc 300 attttgcatt caaattaagg gttaagaaaa gagatatttt aaaatgagag tcacttgatg 360 tgccat 366 &lt;210〉 321 &lt;211&gt; 320 &lt;212&gt; DNA φ &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 38439_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （147)..(147) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 321 acacttggga tttttctcct ctgtcccgag gtcgtcgtct gctttctttt ttgggtttct 60&lt; 220> &lt; 221 &gt; misc_feature &lt; 222> (103) .. (164) &lt; 223 &gt; n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (166) .. (166) &lt; 223 &gt; n is a, g, c or t φ &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (176) .. (203) &lt; 223> n is a, g, c or t &lt; 400> 320 60 120 aggtgctcag agagccggcc cgcctgaatc attctcgatt taactcgaga ccttttcaac ttggcttcct ttcttggttc ataaatgaat tttagtttgg ttnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnntngctt actaannnnn 98677.doc -259 - 180 200533758 nnnnnnnnnn nnnnnnnnnn nnntgctttc tgttgtcatt gctgttgtcc ctctgctacg 240 ttcctattgt cattaaaggt atcacggtcg ccacctggca ttccttctga ccacagcatc 300 attttgcatt caaattaagg gttaagaaaa gagatatttt aaaatgagag tcacttgatg 360 tgccat 366 &lt; 210〉 321 &lt; 211 &gt; 320 &lt; 212 &gt; DNA φ &lt; 213〉 human &lt; 220> &lt; 223 &gt; Probe 38439_at HG-U95Av2 &gt; misc-feature &lt; 222〉 (147) .. (147) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 321 acacttggga tttttctcct ctgtcccgag gtcgtcgtct gctttctttt ttgggtttct 60

ttctagaaga ttgagaagtg catatgacag gctgagagca cctccccaaa cacacaagct 120 ctcagccaca ggcagcttct ccacagnccc cagcttcgca caggctcctg gagggctgcc 180 tgggggaggc agacatggga gtgccaaggt ggccagatgg ttccaggact acaatgtctt 240 tatttttaac tgtttgccac tgctgccctc acccctgccc ggctctggag taccgtctgc 300 cccagacaag tgggagtgaa 320 &lt;210&gt; 322 98677.doc -260-ttctagaaga ttgagaagtg catatgacag gctgagagca cctccccaaa cacacaagct 120 ctcagccaca ggcagcttct ccacagnccc cagcttcgca caggctcctg gagggctgcc 180 tgggggaggc agacatggga gtgccaaggt ggccagatgg ttccaggact acaatgtctt 240 tatttttaac tgtttgccac tgctgccctc acccctgccc ggctctggag taccgtctgc 300 cccagacaag tgggagtgaa 320 &lt; 210 &gt; 322 98677.doc -260-

200533758 &lt;211〉 545 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 38453—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 42, 50, 61·.78， 168， 183, 205..328, 377, 378 &lt;223〉η 為 a，g，c 或 t &lt;221&gt; misc_feature &lt;222〉 380, 381， 403, 405, 412, 415, 416 &lt;223〉n 為 a，g，c 或 t &lt;400〉 322 * cgtggcaatg agactctgca ctatgagacc ttcgggaagg cnagcccctn ctccgcagga nnnnnnnnnn nnnnnnnnac agcacggctg acagagagga tggccaccgc aacttctcct gcctggctgt gctggacttg atgtctcgcg gtggcaacat ctttcacnaa acactcagcc • ccngaagatg ttggagatct atgannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnag cggatgggca cctacggggt gcgagcggct tggaggaggc tgccccnngn nttccggcca tagcaaccat gantngcatg gnccnncacc acggtggtca ctggaactca gtgtgactcc tcagggttga ggtccagccc tggctgaagg actgtgacag gcagcagaga cttgggacat tgccttttct agcccgaata caaacacctg gactt 60 120 180 240 300 360 420 480 540 98677.doc -261 - 545 200533758 &lt;210&gt; 323 &lt;211〉 113 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 38454_g_at HG-U95Av2 &lt;400&gt; 323 cactggaact cagtgtgact cctcagggtt gaggtccagc cctggctgaa ggactgtgac200533758 &lt; 211〉 545 &lt; 212 &gt; DNA &lt; 213〉 human &lt; 220 &gt; &lt; 223〉 Probe 38453-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 42, 50, 61 · .78, 168, 183, 205..328, 377, 378 &lt; 223〉 η is a, g, c or t &lt; 221 &gt; misc_feature &lt; 222〉 380, 381, 403, 405, 412, 415, 416 &lt; 223> n is a, g, c or t &lt; 400> 322 * cgtggcaatg agactctgca ctatgagacc ttcgggaagg cnagcccctn ctccgcagga nnnnnnnnnn nnnnnnnnac agcacggctg acagagagga tggccaccgc aacttctcct gcctggctgt gctggacttg atgtctcgcg gtggcaacat ctttcacnaa acactcagcc • ccngaagatg ttggagatct atgannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnag cggatgggca cctacggggt gcgagcggct tggaggaggc tgccccnngn nttccggcca tagcaaccat gantngcatg gnccnncacc acggtggtca ctggaactca gtgtgactcc tcagggttga ggtccagccc tggctgaagg actgtgacag gcagcagaga cttgggacat tgccttttct agcccgaata caaacacctg gactt 60 120 180 240 300 360 420 480 540 98 677.doc -261-545 200533758 &lt; 210 &gt; 323 &lt; 211> 113 &lt; 212 &gt; DNA &lt; 213> human &lt; 220 &gt; &lt; 223 &gt; Probe 38454_g_at HG-U95Av2 &lt; 400 &gt; 323 cactggaact cagtgtgact cctcagggtt gag cctggctgaa ggactgtgac

aggcagcaga gacttgggac attgcctttt ctagcccgaa tacaaacacc tgg &lt;210&gt; 324 &lt;211〉 412 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38463—s_at HG-U95Av2 &lt;220〉 ^ &lt;221&gt; misc_feature &lt;222〉 （182)·.(208) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221〉mi sc一feature &lt;222〉 （271)·.(341) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 324 tgtcaaagtg actgcgttca tcagttttac actggggctg ctacataata ttttcatttg 98677.doc -262 - 200533758 aacgaagaac ttcaaaaagc acaggactag atgatctctg ttccttttgg ctctaatatg 120 ctacaactgt aggccaatta tcactttacc aattaagagt taggccagat aagtgaaatt 180 tnnnnnnnnn nnnnnnnnnn nnnnnnnnat aggcctaaac tggatttcct tattccaaat 240 cctgtctttt ccccactatt ccattagacc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn naaaatttct cccttatcta 360 ctgtgatgac ttcagaagat acaatggtcc caggggccaa gtagaaagca tt 412aggcagcaga gacttgggac attgcctttt ctagcccgaa tacaaacacc tgg &lt; 210 &gt; 324 &lt; 211〉 412 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 38463—s_at HG-U95Av2 &lt; 220> ^ &gt; misc_feature &lt; 222〉 (182) ·. (208) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221〉 mi sc-feature &lt; 222〉 (271) · (341) 200533758 aacgaagaac ttcaaaaagc acaggactag atgatctctg ttccttttgg ctctaatatg 120 ctacaactgt aggccaatta tcactttacc aattaagagt taggccagat aagtgaaatt 180 tnnnnnnnnn nnnnnnnnnn nnnnnnnnat aggcctaaac tggatttcct - 324 tgtcaaagtg actgcgttca tcagttttac actggggctg ctacataata ttttcatttg 98677.doc -262; &lt; 223 &gt; n is a, g, c or t &lt; 400 & gt tattccaaat 240 cctgtctttt ccccactatt ccattagacc nnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300 nnnnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn naaaatttct cccttatcta 360 ctgtgatgac ttcagaagat acaatcct ggcaggg ccggat

&lt;210&gt; 325 &lt;211&gt; 290 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 38466—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc—feature &lt;222&gt; (184)..(226) _ &lt;223〉n 為 a，g，c 或 t &lt;400〉 325 tcactgtggc catcaggact ttccctgaca gctgtgtact cttaggctaa gagatgtgac 60 tacagcctgc ccctgactgt gttgtcccag ggctgatgct gtacaggtac aggctggaga 120 ttttcacata ggttagattc tcattcacgg gactagttag ctttaagcac cctagaggac 180 tagnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnaagg tagaaatgtc 240 tatgttttct actccaattc ataaatctat tcataagtct ttggtacaag 290 98677 doc - 263 - 200533758 &lt;210〉 326 &lt;211&gt; 319 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38488一sjt HG-U95Av2 &lt;400〉 326 tgtgctgtca aaacaagttt ttctgtcaag aagatgatca gaccttggat cagatgaact&lt; 210 &gt; 325 &lt; 211 &gt; 290 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 38466-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; (184) .. (226) _ &lt; 223〉 n is a, g, c or t &lt; 400〉 325 tcactgtggc catcaggact ttccctgaca gctgtgtact cttaggctaa gagatgtgac 60 tacagcctgc ccctnncatnnggggtggggtggtggggtt nnnnnnnnnn nnnnnnnnnn nnnnnnaagg tagaaatgtc 240 tatgttttct actccaattc ataaatctat tcataagtct ttggtacaag 290 98677 doc-263-200533758 &lt; 210〉 326 &lt; 211 &gt; 319 &lt; 212〉 DNA &lt; 213 &gt; Humans &lt; HG &lt; 138 &gt; Human &lt; 488 -U95Av2 &lt; 400〉 326 tgtgctgtca aaacaagttt ttctgtcaag aagatgatca gaccttggat cagatgaact

cttagaaatg aaggcagaaa aatgtcattg agtaatatag tgactatgaa cttctctcag acttacttta ctcatttttt taatttatta ttgaaattgt acatatttgt ggaataatgt aaaatgttga ataaaaatat gtacaagtgt tgttttttaa gttgcactga tattttacct cttattgcaa aatagcattt gtttaagggt gatagtcaaa ttatgtattg gtggggctgg gtaccaatgc tgcaggtca &lt;210〉 327 φ &lt;211〉 505 &lt;212〉DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 384—at HG-U95Av2 &lt;400〉 327 acgccgagat gccgcgagcc agggccacgt gaccacacgg ccgcgtggcc gggtgcatcg atggtggcgt acggtcactc ctgatcgtgg ccaagatgga gcatcctgcg gcggcgtaga gctacacgcg ccagacgctc cctgactgga ttatctacgg ttcaggtacc ccgcagctct 98677.doc -2()4- 200533758 acggtgtgca tccccatggc tcctacagcc gtctgccctt cacagccctg ggctctggtc 240 aggacgcggc cctggcggtg ctagaagacc ggttccagcc gaacatgacg ctggaggctg 300 ctcaggggct gctggtggaa gccgtcaccg ccgggatctt gggtgacctg ggctccgggg 360 gcaatgtgga cgcatgtgtg atcacaaaga ctggcgccaa gctgctgcgg acactgagct 420 cacccacaga gcccgtgaag aggtctggcc gctaccactt tgtgcctgga accacagctg 480 tcctgaccca gacagtgaag ccact 505cttagaaatg aaggcagaaa aatgtcattg agtaatatag tgactatgaa cttctctcag acttacttta ctcatttttt taatttatta ttgaaattgt acatatttgt ggaataatgt aaaatgttga ataaaaatat gtacaagtgt tgttttttaa gttgcactga tattttacct cttattgcaa aatagcattt gtttaagggt gatagtcaaa ttatgtattg gtggggctgg gtaccaatgc tgcaggtca &lt; 210> 327 φ &lt; 211> 505 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 > &lt; 223> Probe 384-at HG-U95Av2 &lt; 400> 327 acgccgagat gccgcgagcc agggccacgt gaccacacgg ccgcgtggcc gggtgcatcg atggtggcgt acggtcactc ctgatcgtgg ccaagatgga gcatcctgcg gcggcgtaga gctacacgcg ccagacgctc cctgactgga ttatctacgg ttcaggtacc ccgcagctct 98677.doc -2 () 4- 200533758 acggtgtgca tccccatggc tcctacagcc gtctgccctt cacagccctg ggctctggtc 240 aggacgcggc cctggcggtg ctagaagacc ggttccagcc gaacatgacg ctggaggctg 300 ctcaggggct gctggtggaa gccgtcaccg ccgggatctt gggtgacctg ggctccgggg 360 gcaatgtgga cgcatgtgtg atcacaaaga ctggcgccaa gctgctgcgg acactgagct 420 cacccacaga gcccgtgaag aggtctggcc gctaccactt tgtgcctgga accacagctg 480 tcctgaccca ga cagtgaag ccact 505

&lt;210&gt; 328 &lt;211〉 242 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 38584—at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature &lt;222〉 （41)·.(41) Φ &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 328 tattttcctg tcagcatctg agcttgagga tggtagtgag naaatgggcc agggcgcagt 60 cagctccagt cccagagagc tcctctctaa ctcagagcaa ctgaactgag acagaggagg 120 aaaacagagc atcagaagcc tgcagtggtg gttgtgacgg gtaggaggat aggaagacag 180 ggggccccaa cctgggattg ctgagcaggg aagctttgca tgttgctcta aggtacattt 240 tt 242 98677.doc - 265 - 200533758 &lt;210〉 329 &lt;211〉 482 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223〉 Probe 38617一at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature φ &lt;222〉 97, 99， 102·.105， 107， 111， 115·.140, 426, 430 &lt;223〉n 為 a，g，c 或 t &lt;400〉 329 gagatagctc cctgagctgg gccatctgac ttctacctcc catgtttgct ctcccaactc 60 attagctcct gggcagcatc ctcctgagcc acatgtncng gnnnngnaaa ncctnnnnnn 120 nnnnnnnnnn nnnnnnnnnn actcttcatc acaactagat ttgcctcttc taagtgtcta 180 tgagcttgca ccatatttaa taaattggga atgggtttgg ggtattaatg caatgtgtgg 240 ^ tggttgtatt ggagcagggg gaattgataa aggagagtgg ttgctgttaa tattatctta 300 tctattgggt ggtatgtgaa atattgtaca tagacctgat gagttgtggg accagatgtc 360 atctctggtc agagtttact tgctatatag actgtactta tgtgtgaagt ttgcaagctt 420 gctttnaggn ctgagccctg gactcccagc agcagcacag ttcagcattg tgtggctggt 480 tg 482 &lt;210〉 330 &lt;211〉 371 98677.doc -266- 200533758 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 3863Lat HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; 68..83, 115, 116, 136..151, 153..180, 189 &lt;223〉n 為 a，g，c 或 t • &lt;400〉 330 tcctgctcgg catgtgctcc ccctaaggct ctcagcctga gagggggccc ttcgnnctca ngnnnnnnnn nnnnnnnnnn nnnnnnnnnn ccttacaaag ctgtggccag gaagtggccg gtgtaggagt tagcgtgttt gatattgtta cttttgtatg tatgttgaac aggatccagg gctctacccc aggaaaatgt gagctcgttt ctgctccnnn nnnnnnnnnn nnngttcctt ggcatgactc agcccnnnnn nnnnnnnnnn cttgggtcng tccccttttc ccaggtactg gtataaagga tgcccaaggt ctttgtacgt atataataat aattattttt tagagtactg ^ tttttatagc t &lt;210〉 331 &lt;211〉 223 &lt;212&gt; DNA &lt;213〉 人類 &lt;220&gt; &lt;223〉 Probe 38787—at HG-U95Av2 &lt;400&gt; 331 tgccgaaaac tcgtcctccc gagagctgga tgacagcagc agtgagtcca gtgacctcca 98677.doc 267- 200533758 gctggaaggc cccagcaccc tcagggtcct ggacgagaac cttgctgacc cccaagcaga 120 agacagacct ctggttttct ttgacctcaa gattgacaat gaaagtgggt tctcctgggg 180 ctacccccac ccctttctaa tttagtctct gagtcccaaa aag 223 &lt;210&gt; 332 &lt;211&gt; 294 &lt;212&gt; DNA &lt;213&gt; 人類&lt; 210 &gt; 328 &lt; 211〉 242 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 38584-at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc-feature &lt; 222〉 . (41) · (41) Φ &lt; 223 &gt; n is a, g, c or t &lt; 400> 328 tattttcctg tcagcatctg agcttgagga tggtagtgag naaatgggcc agggcgcagt 60 cagctccagt cccagagagc tcctctctaa ctcagagcaa ctgaactgag acagaggagg 120 aaaacagagc atcagaagcc aggaagacag 180 ggggccccaa tgcagtggtg gttgtgacgg gtaggaggat cctgggattg ctgagcaggg aagctttgca tgttgctcta aggtacattt 240 tt 242 98677.doc-265-200533758 &lt; 210〉 329 &lt; 211〉 482 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220〉 &lt; 223〉 Probe 38617-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature φ &lt; 222〉 97, 99, 102 · .105, 107, 111, 115 · .140, 426, 430 &lt; 223> n is a, g, c or t &lt; 400 〉 329 gagatagctc cctgagctgg gccatctgac ttctacctcc catgtttgct ctcccaactc 60 attagctcct gggcagcatc ctcctgagcc acatgtncng gnnnngnaaa ncctnnnnnn 120 nnnnnnnnnn nnnnnnnnnn actcttcatc agacttt c taagtgtcta 180 tgagcttgca ccatatttaa taaattggga atgggtttgg ggtattaatg caatgtgtgg 240 ^ tggttgtatt ggagcagggg gaattgataa aggagagtgg ttgctgttaa tattatctta 300 tctattgggt ggtatgtgaa atattgtaca tagacctgat gagttgtggg accagatgtc 360 atctctggtc agagtttact tgctatatag actgtactta tgtgtgaagt ttgcaagctt 420 gctttnaggn ctgagccctg gactcccagc agcagcacag ttcagcattg tgtggctggt 480 tg 482 &lt; 210> 330 &lt; 211> 371 98677.doc -266- 200533758 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220〉 &lt; 223 &gt; Probe 3863Lat HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 68..83 , 115, 116, 136..151, 153..180, 189 &lt; 223〉 n is a, g, c or t • &lt; 400〉 330 tcctgctcgg catgtgctcc ccctaaggct ctcagcctga gagggggccc ttcgnnctca ngnnnnnnnn nnnnnnnnag gtncc ngtnnnnnnnnnn cttttgtatg tatgttgaac aggatccagg gctctacccc aggaaaatgt gagctcgttt ctgctccncn nnnnnnnnnn nnngttcctt ggcatgactc agcccnnnnn nnnnnnnnnn cttgggtcng tccccttttc ccaggtactg gtcaaagga aggt ctttgtacgt atataataat aattattttt tagagtactg ^ tttttatagc t &lt; 210〉 331 &lt; 211〉 223 &lt; 212 &gt; DNA &lt; 213〉 humans &lt; 220 &gt; &lt; 223〉 Probe 38787—at HG-U95Av2 &lt; 400 &gt; c tccccgatac gagagctgga tgacagcagc agtgagtcca gtgacctcca 98677.doc 267- 200533758 gctggaaggc cccagcaccc tcagggtcct ggacgagaac cttgctgacc cccaagcaga 120 agacagacct ctggttttct ttgacctcaa gattgacaat gaaagtgggt tctcctgggg 180 ctacccccac ccctttctaa tttagtctct gagtcccaaa aag 223 &lt; 210 &gt; 332 &lt; 211 &gt; 294 &lt; 212 &gt; DNA &lt; 213 &gt; human

&lt;220〉 &lt;223&gt; Probe 38880—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 68, 110, 118, 125, 184, 224 &lt;223〉n 為 a, g, c 或 t &lt;400〉 332 gcacccacgg gtgtgctgga tactggagtt tgagaggagg gaggtgctgg ggccaaagga 60 • gacactanaa aagtggtaga tgggacaggt aagtggcaga ggtgaggggn taagttanaa 120 tgtanaaggg cagtaattag gggtgaggga aaggagatag gggaccctag gaggtagagt 180 gggnccatgt cgtgaggcag ttgaagagtt gaggaaaggt tttnctgggc cctactgctc 240 ccctctgctg caggtaagtc agagcagctt taccacagct tcaggccacg agag 294 &lt;210〉 333 &lt;211〉 535 &lt;212&gt; DNA &lt;213&gt;人類 93677.doc - 268 - 200533758 &lt;220〉 &lt;223〉 Probe 38916_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; (31)..(52) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature • &lt;222〉 （250)..(282) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （449)..(463) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 333 gaacctttca gtctccgcta gctctttcct nnnnnnnnnn nnnnnnnnnn nngttttatc 60 ^ gttaagtgcc ccacagagac actttaccag gaggctggga gagttctcca gatttgggag 120 aggcgcagag acagtgtgtg agccgagccc tgtctcagca atccacctgg aggagctaga 180 gtatcctcct ccctttacca ttcagaccga gagaaaaagc ccagcttgtg tgcaccctcg 240 tggggttaan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntttgtttt gatgtaaggc 300 tctgtggttt gggggggaac atctgtaaac attattagtt gatttggggt ttgtctttga 360 tggtttctat ctgcaattat cgtcatgtat atttaagtgt ctgttataga aaacccacac 420 ccactgtcct gtaaactttt ctcagtgtnn nnnnnnnnnn nnntcacatt ttaattgcca 480 98677.doc -269 - 200533758 cctcgtattt cacctctaca tttgaaatct ggcgtctgtt tcaagccagt gtgtt 535 &lt;210〉 334 &lt;211〉 328 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 38944_at HG-U95Av2 • &lt;400〉 334 ctctcagaac atactgattg ggaggtgcgt gttcagcaga acctgcacac aggacagcgg 60 gaaaaatcga tgagcgccac ctctttaaaa actcacttac gtttgtcctt tttcactttg 120 aaaagttgga aggatctgct gaggcccagt gcatatgcaa tgtatagtgt ctattatcac 180 attaatctca aagagatteg aatgacggta agtgttctca tgaagcagga ggcccttgtc 240 gtgggatggc atttggtctc aggcagcacc acactgggtg cgtctccagt catctgtaag 300 agettgctcc agattetgat gcatacgg 328&lt; 220> &lt; 223 &gt; Probe 38880-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 68, 110, 118, 125, 184, 224 &lt; 223> n is a, g, c or t &lt; 400> 332 gcacccacgg gtgtgctgga tactggagtt tgagaggagg gaggtgctgg ggccaaagga 60 • gacactanaa aagtggtaga tgggacaggt aagtggcaga ggtgaggggn taagttanaa 120 tgtanaaggg cagtaattag gggtgaggga aaggagatag gggaccctag gaggtagagt 180 gggnccatgt cgtgaggcag ttgaagagtt gaggaaaggt tttnctgggc cctactgctc 240 ccctctgctg caggtaagtc agagcagctt taccacagct tcaggccacg agag 294 &lt; 210> 333 &lt; 211> 535 &lt; 212 &gt; DNA &lt; 213 &gt; human 93677.doc-268-200533758 &lt; 220〉 &lt; 223〉 Probe 38916_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; (31 ) .. (52) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature • &lt; 222> (250) .. (282) &lt; 223 &gt; n is a, g , C or t &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222〉 (449) .. (463) &lt; 223 &gt; n is a, g, c or t &lt; 400> 333 gaacctttca gtctccgcta gctctttcct nnn nnnnnnn nnnnnnnnnn nngttttatc 60 ^ gttaagtgcc ccacagagac actttaccag gaggctggga gagttctcca gatttgggag 120 aggcgcagag acagtgtgtg agccgagccc tgtctcagca atccacctgg aggagctaga 180 gtatcctcct ccctttacca ttcagaccga gagaaaaagc ccagcttgtg tgcaccctcg 240 tggggttaan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntttgtttt gatgtaaggc 300 tctgtggttt gggggggaac atctgtaaac attattagtt gatttggggt ttgtctttga 360 tggtttctat ctgcaattat cgtcatgtat atttaagtgt ctgttataga aaacccacac 420 ccactgtcct gtaaactttt ctcagtgtnn nnnnnnnnnn nnntcacatt ttaattgcca 480 98677.doc -269-200533758 cctcgtattt cacctctaca tttgaaatct ggcgtctgtt tcaagccagt gtgtt 535 &lt; 210〉 334 &lt;211; 328 &lt; 212 &gt; DNA &lt;213; _gt &gt; human &gt; U95Av2 • &lt; 400〉 334 ctctcagaac atactgattg ggaggtgcgt gttcagcaga acctgcacac aggacagcgg 60 gaaaaatcga tgagcgccac ctctttaaaa actcacttaccagt agt agt agtat agtat agtat agtat a tgaagcagga ggcccttgtc 240 gtgggatggc atttggtctc aggcagcacc acactgggtg cgtctccagt catctgtaag 300 agettgctcc agattetgat gcatacgg 328

&lt;210&gt; 335 &lt;211〉 473 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223〉 Probe 38970—s—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 55, 76, 77, 79 &lt;223&gt; n 為 a，g，c 或 t 98677.doc - 270 - 60 200533758 &lt;400〉 335 accatccgtt gcagaagcct ccaggagcag caatcctaag agtgggaggc agccnaagac ccccttcctt caaaanncnt cccggaagtg gtttcaggcc ctctagttgc catgaccaat ttgtgtgtgt gtttaatttt tgcttcaagc tctgtagcag gacctgcccc acgcacaccc ctacccctct gtgaggagct gtgggaagtg tgggtttgtc tccagaacag aagagaatga tggatattct ggctctgggg ccctctccac caccactcac agtagccttg ctgaagccat&lt; 210 &gt; 335 &lt; 211> 473 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 38970-s-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; 55, 76, 77, 79 &lt; 223 &gt; n is a, g, c or t 98677.doc-270-60 200533758 &lt; 400> 335 accatccgtt gcagaagcct ccaggagcag caatcctaag agtgggaggc agccnaagac ccccttcctt caaaanncg cgt cgtggt cgtgcat cgtggt tctgtagcag gacctgcccc acgcacaccc ctacccctct gtgaggagct gtgggaagtg tgggtttgtc tccagaacag aagagaatga tggatattct ggctctgggg ccctctccac caccactcac agtagccttg ctgaagccat

120 180 240 300 360 420 473 cacagatggg agaaggccat gccagccacg tccgccgagg ggcgccagcc tgaagctgcc aggccctgag gttcagaccc tggaccccat agctggaggc ctgtggtgcc agaagcccag attagggtgg ctgtccatcc ctggatagct atttgcacga atcatggaca taa &lt;210&gt; 336 &lt;211〉 265 &lt;212&gt; DNA &lt;213&gt;人類 φ &lt;220&gt; &lt;223&gt; Probe 38971_r—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 26, 47, 48, 50 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 336 60 gcaatcctaa gagtgggagg cagccnaaga cccccttcct tcaaaanncn tcccggaagt ggtttcaggc cctctagttg ccatgaccaa tttgtgtgtg tgtttaattt ttgcttcaag 98677.doc -271 - 120 200533758 ctctgtagca ggacctgccc cacgcacacc cctacccctc tgtgaggagc tgtgggaagt £tgggtttgt ctccagaaca gaagagaatg atggatattc tggctctggg gccctctcca ccaccactca cagtagcctt gctga &lt;210〉 337 &lt;211&gt; 527 &lt;212&gt; DNA &lt;213〉人類120 180 240 300 360 420 473 cacagatggg agaaggccat gccagccacg tccgccgagg ggcgccagcc tgaagctgcc aggccctgag gttcagaccc tggaccccat agctggaggc ctgtggtgcc agaagcccag attagggtgg ctgtccatcc ctggatagct atttgcacga atcatggaca taa &lt; 210 &gt; 336 &lt; 211> 265 &lt; 212 &gt; DNA &lt; 213 &gt; human φ &lt; 220 &gt; &lt; 223 &gt; Probe 38971_r-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 26, 47, 48, 50 &lt; 223 &gt; n is a, g, c or t &lt; 400> 336 60 gcaatcctaa gagtgggagg cagccnaaga cccccttcct tcaaaanncn tcccggaagt ggtttcaggc cctctagttg ccatgaccaa tttgtgtgtg tgtttaattt ttgcttcaag 98677.doc -271 - 120 200533758 ctctgtagca ggacctgccc cacgcacacc cctacccctc tgtgaggagc tgtgggaagt £ tgggtttgt ctccagaaca gaagagaatg atggatattc tggctctggg gccctctcca ccaccactca cagtagcctt gctga &lt; 210> 337 &lt; 211 &gt; 527 &lt; 212 &gt; DNA &lt; 213〉 Human

&lt;220&gt; &lt;223〉 Probe 39032—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 35..102， 123, 267, 270..287, 295, 298, 306 &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 313, 315..338, 430..445&lt; 220 &gt; &lt; 223> Probe 39032-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 35..102, 123, 267, 270..287, 295, 298, 306 &lt; 223 〉 N is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> 313, 315..338, 430..445

&lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 337 atgacacaaa actatgagag tgacaaaatg gtgannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgtagtgt aactattttg tancaataga tggctgtctg aaaaaccaca ggactgtaac aggaggtgtg cctaaagaaa tactatttag gacttttata ttttaangan gttgtacaga tatagatcta nnnnnnnnnn ttgaaattta cataaaaact nnnnnnntca gttgtttcat gctacatgac ctttngtngt 98677.doc -272- 200533758 aatctngaaa tcntnnnnnn nnnnnnnnnn nnnnnnnnaa tccttgttea ctgaagtctt 360 tcaattgagc tggttgaata ctttgaaaaa tgctcagttc taactaatga aatggatttc 420 ccagtagggn nnnnnnnnnn nnnnntgtat agtagttata tgcatatgtt tctgtgcatg 480 ttctctacac aattgtaagg tgtcactgta tttaactgtt gcacttg 527 &lt;210〉 338 &lt;211&gt; 469 &lt;212&gt; DNA 春&lt;2丨3&gt;人類 &lt;220〉 &lt;223&gt; Probe 39070—at HG-U95Av2 &lt;400&gt; 338&Lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 337 atgacacaaa actatgagag tgacaaaatg gtgannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgtagtgt aactattttg tancaataga tggctgtctg aaaaaccaca ggactgtaac aggaggtgtg cctaaagaaa tactatttag gacttttata ttttaangan gttgtacaga tatagatcta nnnnnnnnnn ttgaaattta cataaaaact nnnnnnntca gttgtttcat gctacatgac ctttngtngt 98677. doc -272- 200533758 aatctngaaa tcntnnnnnn nnnnnnnnnn nnnnnnnnaa tccttgttea ctgaagtctt 360 tcaattgagc tggttgaata ctttgaaaaa tgctcagttc taactaatga 420 ccagtagggn nnnnnnnnnn nnnnntgtat agtagttata tgcatatgtt tctgtgcatg 480 ttctctacac aattgtaagg tgtcactgta tttaactgtt gcacttg 527 & lt aatggatttc; 210> 338 &lt; 211 &gt; 469 &lt; 212 &gt; DNA spring &lt; 2 丨 3 &gt; Human &lt; 220> &lt; 223 &gt; Probe 39070-at HG-U95Av2 &lt; 400 &gt; 338

ggggccgtct tcctcctgtc tctttccttt caccctagcc tgactggaag cagaaaatga 60 ccaaatcagt atttttttta atgaaatatt attgctggag gcgtcccagg caagcctggc 120 tgtagtagcg agtgatctgg cggggggcgt ctcagcaccc tccccagggg gtgeatetea 180 gccccctctt tccgtccttc ccgtccagcc ccagccctgg gcctgggctg ccgacacctg 240 ggccagagcc cctgctgtga ttggtgctcc ctgggcctcc cgggtggatg aagccaggcg 300 tcgccccctc cgggagccct ggggtgagcc gccggggccc ccctgctgcc agcctccccc 360 gtccccaaca tgcatctcac tctgggtgtc ttggtctttt attttttgta agtgtcattt 420 gtataactct aaacgcccat gatagtaget tcaaactgga aatagcgaa 469ggggccgtct tcctcctgtc tctttccttt caccctagcc tgactggaag cagaaaatga 60 ccaaatcagt atttttttta atgaaatatt attgctggag gcgtcccagg caagcctggc 120 tgtagtagcg agtgatctgg cggggggcgt ctcagcaccc tccccagggg gtgeatetea 180 gccccctctt tccgtccttc ccgtccagcc ccagccctgg gcctgggctg ccgacacctg 240 ggccagagcc cctgctgtga ttggtgctcc ctgggcctcc cgggtggatg aagccaggcg 300 tcgccccctc cgggagccct ggggtgagcc gccggggccc ccctgctgcc agcctccccc 360 gtccccaaca tgcatctcac tctgggtgtc ttggtctttt attttttgta agtgtcattt 420 gtataactct aaacgcccat gatagtaget tcaaactgga aatagcgaa 469

&lt;210〉 339 &lt;211&gt; 478 &lt;212&gt; DNA 98677.doc -273 - 200533758 &lt;213〉人類 &lt;220〉 &lt;223〉 Probe 39071一at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （59)..(59) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 • &lt;221〉mi sc一feature &lt;222〉 （259)..(276) &lt;223〉n 為 a，g，c 或 t &lt;400〉 339&lt; 210> 339 &lt; 211 &gt; 478 &lt; 212 &gt; DNA 98677.doc -273-200533758 &lt; 213〉 Human &lt; 220〉 &lt; 223〉 Probe 39071-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (59) .. (59) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 • &lt; 221〉 mi sc-feature &lt; 222〉 (259) .. (276) ) &lt; 223〉 n is a, g, c or t &lt; 400〉 339

60 120 180 240 300 360 420 actcagtgtt ttggagagta ttccttttag tttgttggtt ggctggtttg aacgatagna aatatgcagc atgcaatata tgcttatatt tcattttaat ttctgatata taatgaactt cttgggagag gtactgaatc tttgatgttt tttgtcattg ttctcaagtg caatataaca atgtaaccaa atctagataa tttcaaagtt gtcattaatt tagtaagcct aatataaaca aatatttgta ttatttttnn nnnnnnnnnn nnnnnnttaa gtgaggttat ttacccctaa atggtccatt ctgcattgta tttcaggctg gaaatgaatt attctttacc agttttgaaa cactttgaaa tatcctaagg taacttggaa gctgtgtagt atatcaaatt aatttgctac ctaataacat agaaagtaaa tatctttgtg gtcacccaca ttgggtgaga cagaaaat60 120 180 240 300 360 420 actcagtgtt ttggagagta ttccttttag tttgttggtt ggctggtttg aacgatagna aatatgcagc atgcaatata tgcttatatt tcattttaat ttctgatata taatgaactt cttgggagag gtactgaatc tttgatgttt tttgtcattg ttctcaagtg caatataaca atgtaaccaa atctagataa tttcaaagtt gtcattaatt tagtaagcct aatataaaca aatatttgta ttatttttnn nnnnnnnnnn nnnnnnttaa gtgaggttat ttacccctaa atggtccatt ctgcattgta tttcaggctg gaaatgaatt attctttacc agttttgaaa cactttgaaa tatcctaagg taacttggaa gctgtgtagt atatcaaatt aatttgctac ctaataacat agaaagtaaa tatctttgtg gtcacccaca ttgggtgaga cagaaaat

&lt;210&gt; 340 &lt;211&gt; 398 &lt;212〉 DNA 98o&quot;^.doc -274- 478 200533758 &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 3908Lat HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 82..100, 102, 103, 114..117, 119, 121, 142, 149..152, 154..156 &lt;223〉η 為 a, g, c 或 t &lt;220〉 &lt;221〉 misc_feature • &lt;222&gt; 158..160, 163, 165..170, 172..176, 178, 179, 181 &lt;223〉n 為 a, g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 183..188, 190..226, 323..351 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 340 gtgatcctta tcagggagag caggaatcct tattcccggt gtcgctagta ctcatctctg 60 ccgcctcctg tctgccccca gnnnnnnnnn nnnnnnnnnn cnncgaaccc gcgnnnnanc 120&lt; 210 &gt; 340 &lt; 211 &gt; 398 &lt; 212〉 DNA 98o &quot; ^. doc -274- 478 200533758 &lt; 213〉 Human &lt; 220 &gt; &lt; 223 &gt; Probe 3908Lat HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; 82..100, 102, 103, 114..117, 119, 121, 142, 149..152, 154..156 &lt; 223> η is a, g, c or t &lt; 220〉 &lt; 221〉 misc_feature • &lt; 222 &gt; 158..160, 163, 165..170, 172..176, 178, 179, 181 &lt; 223> n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 183..188, 190..226, 323..351 &lt; 223 &gt; n is a, g, c or t &lt; 400> 340 gtgatcctta tcagggagag caggaatcct tattcccggt gtccatctctgct 60 ccgcctcctg tctgccccca gnnnnnnnnn nnnnnnnnnn cnncgaaccc gcgnnnnanc 120

ntgtcccgac tctagccgcc tnttcagcnn nncnnngnnn ccnannnnnn cnnnnncnnc 180 ngnnnnnncn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnaaat gcacctcctg 240 caagaaaagc tgctgctcct gctgccctgt gggctgtgcc aagtgtgccc agggctgcat 300 ctgcaaaggg gcgtcggaca agnnnnnnnn nnnnnnnnnn nnnnnnnnnn nccccgctcc 360 cagatgtaaa gaacgcgact tccacaaacc tggatttt 398 &lt;210〉 341 986^7.d〇c 275 -ntgtcccgac tctagccgcc tnttcagcnn nncnnngnnn ccnannnnnn cnnnnncnnc 180 ngnnnnnncn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnaaat gcacctcctg 240 caagaaaagc tgctgctcct gctgccctgt gggctgtgcc aagtgtgccc agggctgcat 300 ctgcaaaggg gcgtcggaca agnnnnnnnn nnnnnnnnnn nnnnnnnnnn nccccgctcc 360 cagatgtaaa gaacgcgact tccacaaacc tggatttt 398 &lt; 210> 341 986 ^ 7.d〇c 275--

200533758 &lt;211&gt; 578 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 39107_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （93)..(108) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 341 acttcagtgt cagtatccct gccttcagtc ttctttagaa atcacatctg tgttcaatcc attgtttaga gggagtgtat ttttcctgtt ccnnnnnnnn nnnnnnnngt tcacaattgg atcacaatgc agaggagtct gttcctcccc cgtcggcttc tcggtgctgg gagggtgacc tgtcccagat gactcatcac cctgacatgc tcttgacaaa ggacaccacc aagaggagat ggcagctgta ccggtgcagc ctctgtctga gggggatatt tgcctcagtg tgattaaaaa tcagtcatga aagatttttg aattcagatt atttttatca ggaacagatt ttgaacatcc200533758 &lt; 211 &gt; 578 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 39107_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (93). (108) &lt; 223 &gt; n is a, g, c or t &lt; 400> 341 acttcagtgt cagtatccct gccttcagtc ttctttagaa atcacatctg tgttcaatcc attgtttaga gggagtgtat ttttcctgtt ccnnnnnnnn nnnnnnnngt tcacaattgg atcacaatgc agaggagtct gttcctcccc cgtcggcttc tcggtgctgg gagggtgacc tgtcccagat gactcatcac cctgacatgc tcttgacaaa ggacaccacc aagaggagat ggcagctgta ccggtgcagc ctctgtctga gggggatatt tgcctcagtg tgattaaaaa tcagtcatga aagatttttg aattcagatt atttttatca ggaacagatt ttgaacatcc

tgaaatcttt tccctggcat catattaggt tttctttgtt cactatgatg taaagtttca gactcttgat atttttaata tcaacataga cggtaggaca aggaacggta ccagaaatga gtaaagagac aataatgata agatcgattt atcaagacat aacaacccca aatgtatatg cactaaataa cagcttcaaa atacatgaag caaaatggtgaaatcttt tccctggcat catattaggt tttctttgtt cactatgatg taaagtttca gactcttgat atttttaata tcaacataga cggtaggaca aggaacggta ccagaaatga gtaaagagac aataatgata agatcgattt atcaagacat aacaacccca catcaata aatgtata

&lt;21〇&gt; 342 &lt;211&gt; 328 &lt;212&gt; DNA 60 120 180 240 300 360 420 480 540 98677.doc -276 - 578 200533758 &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 39119—s—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 26, 51， 53, 68..84, 86, 243 &lt;223〉η 為 a，g，c 或 t &lt;400〉 342 60 120 180 240 300 328 ^ gtcccggatg ttgaggatcc cgcaanccga ggagcctggg gagagctttt ntnacaaggt catgagannn nnnnnnnnnn nnnncntgca gcggctgcag acctggtggc acggggttct ggcctgggtg aaggagaagg tggtggccct ggtccatgca gtgcaggccc tctggaaaca gttccagagt ttctgctgct ctctgtcaga gctcttcatg tcctctttcc agtcctacgg agncccacgg ggggacaagg aggagctgac accccagaag tgctctgaac cccaatcctc aaaatgaaga tactgacacc acctttgc φ &lt;210&gt; 343 &lt;211&gt; 297 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 39120_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc—feature &lt;222〉 （29)..(29) &lt;223〉n 為 a，g，c 或 t 98677.doc -277- 200533758 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 （95)..(129) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 343 tgtcccgctg cgtgttttcc tcttgatcng ggaactcctg cttctccttg cctcgaaatg gaccccaact gcicctgctc gcctgttggc tcctnnnnnn nnnnnnnnnn nnnnnnnnnn 鲁 nnnnnnnnna aatgcacctc ctgcaagaag agctgctgct cctgctgccc tgtgggctgt gccaagtgtg cccagggctg catctgcaaa gggacgtcag acaagtgcag ctgctgtgcc tgatgccagg acagctgtgc tctcagatgt aaatagagca acctatataa acctgga &lt;210&gt; 344 &lt;211&gt; 352 &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220&gt; W &lt;223〉 Probe 39253—s—at HG-U95Av2 &lt;400〉 344 aagcagacag ctatcggaag aaggtagtgc tagatgggga ggaagtccag atcgatatct tagatacagc tgggcaggag gactacgctg caattagaga caactacttc cgaagtgggg aggggttcct ctgtgttttc tctattacag aaatggaatc ctttgcagct acagctgact tcagggagca gattttaaga gtaaaagaag atgagaatgt tccatttcta ctggttggta acaaatcaga tttagaagat aaaagacagg tttctgtaga agaggcaaaa aacagagctg 60 120 180 240 297 60 120 180 240 98677.doc - 278 - 300 200533758 352 agcagtggaa tgttaactac gtggaaacat ctgctaaaac acgagctaat gt &lt;210&gt; 345 &lt;211&gt; 588 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 39267^at HG-U95Av2 &lt;220〉 • &lt;221&gt; misc^feature &lt;222&gt; (75)..(93) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221〉 misc_feature &lt;222〉 （399)..(434) &lt;223〉 n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature _ &lt;222〉 （458)..(472) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 345 60 120 180 tgcacatgaa gtgagcttgg cagtatttca gctggctgga ggaattggag aaaggcccca accaggtttc tgaannnnnn nnnnnnnnnn nnnagaaact ggacttttta caagtcttta caaaactgtc aataataatg gcagtactaa gagatttata atcataatgt ttacaatgca gcctactgga ttgtctctag atctgttttt cttaaacact aacagaataa ttctttataa 98677.doc -279- 240 300 300&lt; 21〇 &gt; 342 &lt; 211 &gt; 328 &lt; 212 &gt; DNA 60 120 180 240 300 360 420 480 540 98677.doc -276-578 200533758 &lt; 213> Human &lt; 220 &gt; &lt; 223 &gt; Probe 39119— s—at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 26, 51, 53, 68..84, 86, 243 &lt; 223> η is a, g, c or t &lt; 400> 342 60 120 180 240 300 328 ^ gtcccggatg ttgaggatcc cgcaanccga ggagcctggg gagagctttt ntnacaaggt catgagannn nnnnnnnnnn nnnncntgca gcggctgcag acctggtggc acggggttct ggcctgggtg aaggagaagg tggtggccct ggtccatgca gtgcaggccc tctggaaaca gttccagagt ttctgctgct ctctgtcaga gctcttcatg tcctctttcc agtcctacgg agncccacgg ggggacaagg aggagctgac accccagaag tgctctgaac cccaatcctc aaaatgaaga tactgacacc acctttgc φ &lt; 210 &gt; 343 &lt; 211 &gt; 297 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 39120_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> (29) .. (29). (29) &lt; 223〉 n is a, g, c or t 98677.doc -277- 200533758 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222〉 (95) .. (129) & l t; 223 &gt; n is a, g, c or t &lt; 400> 343 tgtcccgctg cgtgttttcc tcttgatcng ggaactcctg cttctccttg cctcgaaatg gaccccaact gcicctgctc gcctgttggc tcctnnnnnn nnnnnnnnnn nnnnnnnnnn Lu nnnnnnnnna aatgcacctc ctgcaagaag agctgctgct cctgctgccc tgtgggctgt gccaagtgtg cccagggctg catctgcaaa gggacgtcag acaagtgcag ctgctgtgcc tgatgccagg acagctgtgc tctcagatgt aaatagagca acctatataa acctgga &lt; 210 &gt; 344 &lt; 211 &gt; 352 &lt; 212 &gt; DNA &lt; 213 &gt; humans &lt; 220 &gt; W &lt; 223〉 Probe 39253—s-at HG-U95Av2 &lt; 400> 344 aagcagacag ctatcggaag aaggtagtgc tagatgggga atggggatgggt agg gactacgctg caattagaga caactacttc cgaagtgggg aggggttcct ctgtgttttc tctattacag aaatggaatc ctttgcagct acagctgact tcagggagca gattttaaga gtaaaagaag atgagaatgt tccatttcta ctggttggta acaaatcaga tttagaagat aaaagacagg tttctgtaga agaggcaaaa aacagagctg 60 120 180 240 297 60 120 180 240 98677.doc - 278 - 300 200533758 352 agcagtggaa tgttaactac gtggaaacat ctgctaaaac acgagctaat gt &lt; 210 &gt; 345 &lt; 211 &gt; 588 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 39267 ^ at HG-U95Av2 &lt; 220> • &lt; 221 &gt; misc ^ feature &lt; 222 &gt; (75). ) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221〉 misc_feature &lt; 222〉 (399) .. (434) &lt; 223> n is a, g, c or t &lt; 220> &lt; 221 &gt; misc-feature _ &lt; 222> (458) .. (472) &lt; 223 &gt; n is a, g, c or t &lt; 400> 345 60 120 180 tgcacatgaa gtgagcttgg cagtatttca gctggctgga ggaattggag aaaggcccca accaggttt tgaannnnnn nnnnnnnnnn nnnagaaact ggacttttta caagtcttta caaaactgtc aataataatg gcagtactaa gagatttata atcataatgt ttacaatgca gcctactgga ttgtctctag atctgttttt cttaaacact aacagaataa ttctttataa 98677 300.doc -279-279

200533758 ataggtaagc cttacacttg ttaaagaaat ttacctctaa tttcagtctc actaatgtaa aatactggga cttaagtata caattcagtc actaactgta cagttttatg tggggaacaa ttcatgcagg ctactggaaa attaaatctt attaccaann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncaagat gatgttttgc agcattcnnn nnnnnnnnnn nnaatggaga gggcagagaa gactttatac aaccagtttt tccattgcag agtcttaaga aagattatta gatgacttac ctatatggac taatgccatc caggaactca gaggtatg &lt;210〉 346 &lt;211&gt; 390 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 39300—at HG-U95Av2 &lt;220〉 &lt;221〉mi sc一feature &lt;222&gt; (125)..(163) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 346 gaggcaggaa tctccatttt tgtgcttttt gaaaatgcaa tgaattccta tacgggggag cgggaaaggt gcctcagaga gagacaagtc tggatgaggg aaatattgaa tattctcaat caaannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngacttga aagacctgag tccattacgt tgagaaggga cctgctgatt gctttgattc cccctggcaa gtgctccctg gttgtgaatg ccaggcacta gagatggtga ggggttgggg ggcagttggg cacacacagt 360 420 480 540 588 60 120 180 240 98677.aoc -280- 300 360 200533758 390 gtaagagcaa ttcagagccg ttagtcctgc actagccctc aagctgctgg caacacctag agaaggtcga agggccctgc cagagatccc &lt;210&gt; 347 &lt;211〉 398 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220〉 &lt;223〉 Probe 39310—at HG-U95Av2200533758 ataggtaagc cttacacttg ttaaagaaat ttacctctaa tttcagtctc actaatgtaa aatactggga cttaagtata caattcagtc actaactgta cagttttatg tggggaacaa ttcatgcagg ctactggaaa attaaatctt attaccaann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncaagat gatgttttgc agcattcnnn nnnnnnnnnn nnaatggaga gggcagagaa gactttatac aaccagtttt tccattgcag agtcttaaga aagattatta gatgacttac ctatatggac taatgccatc caggaactca gaggtatg &lt; 210> 346 &lt; 211 &gt; 390 &lt; 212> DNA &lt; 213 &gt; Humans &lt; 220〉 &lt; 223〉 Probe 39300-at HG-U95Av2 &lt; 220〉 &lt; 221〉 mi sc-feature &lt; 222 &gt; (125) .. (163) &lt; 223 &gt; n is a, g, c or t &lt; 400> 346 gaggcaggaa tctccatttt tgtgcttttt gaaaatgcaa tgaattccta tacgggggag cgggaaaggt gcctcagaga gagacaagtc tggatgaggg aaatattgaa tattctcaat caaannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngacttga aagacctgag tccattacgt tgagaaggga cctgctgatt gctttgattc cccctggcaa gtgctccctg gttgtgaatg ccaggcacta gagatggtga ggggttgggg ggcagttggg cacacacagt 360 420 480 540 588 60 120 180 240 98677.aoc -280- 30 0 360 200533758 390 gtaagagcaa ttcagagccg ttagtcctgc actagccctc aagctgctgg caacacctag agaaggtcga agggccctgc cagagatccc &lt; 210 &gt; 347 &lt; 211〉 398 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 95-lt> 220> &lt; 220>

&lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 45, 46, 56, 221, 222, 312..329, 335..352 &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 347 gcaaagagcc cataaatcct gaccaatcca actctgaatt ttaanncaaa agcgtnaaaa aaaagattcc ctccttaccc ccaacccact cttttttccc accacccact ctcctctgcc tcagtaagta tctggaggaa gaaaacaggt gaaagaagaa gtaaaaacca tttagtatta&lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 45, 46, 56, 221, 222, 312..329, 335..352 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 347 gcaaagagcc cataaatcct gaccaatcca actctgaatt ttaanncaaa agcgtnaaaa aaaagattcc ctccttaccc ccaacccact cttttttccc accacccact ctcctctgcc tcagtaagta tctggaggaga gaaaacaggt gaaagaagaa gttagtaaac

60 120 180 240 300 360 gtattagaat gaagtcaaac tgtgccacac atggtgaatg nnaaaaaaaa aaaagaggct gtgttttgtc acacagggca gtcattcagc accagagcac gtgatggtct gagactctct taggagcaga gnnnnnnnnn nnnnnnnnng tgggnnnnnn nnnnnnnnnn nnggggcaac tgagtctgcg ggagaagagc ggccctatgc atggtgta60 120 180 240 300 360 gtattagaat gaagtcaaac tgtgccacac atggtgaatg nnaaaaaaaa aaaagaggct gtgttttgtc acacagggca gtcattcagc accagagcac gtgatggtct gagactct tagggagcaga gnnnnnnnnnnnnnnnnncngggagggg

&lt;210&gt; 348 &lt;211&gt; 545 &lt;212〉 DNA 98677.doc -2S!- 398&lt; 210 &gt; 348 &lt; 211 &gt; 545 &lt; 212> DNA 98677.doc -2S!-398

200533758 &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 39327.at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 73, 209, 211， 302, 306, 307, 393 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 348 ^ ggttccatca caagctatgt ttaaaaagaa aattggtgtt tggcaaacgg aacagaacct ttgatgagag cgnttcacag ggacactgtc tgggggtgca gtgcaagccc ccggcctctt ccctgggaac ctctgaactc ctccttcctc tgggctctct gtaacatttc accacacgtc agcatctaat cccaagacaa acattcccnc ntgctcgaag cagctgtata gcctgtgact ctccgtgtgt cagctccttc cacacctgat tagaacattc ataagccaca tttagaaaca gntttnnttt cagctgtcac ttgcacacat actgcctagt tgtgaaccaa atgtgaaaaa acctccttea tcccattgtg tatctgatac etneegaggg ccaagggtgt gtgttgacaa cgccgctccc agccggccct ggttgcgtcc acgtcctgaa caagagccgc tteeggatgg ctcttcccaa gggaggagga gctcaagtgt cgggaactgt ctaacttcag gttgtgtgag tgcgt &lt;210&gt; 349 &lt;211&gt; 417 &lt;212〉 DNA &lt;213&gt;人類 60 120 180 240 300 360 420 480 540 545 98677.doc - 282 - 200533758 &lt;220&gt; &lt;223〉 Probe 39333—at HG-U95Av2 &lt;220&gt; &lt;221〉misc一feature &lt;222〉 （264)..(278) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 （345)..(346) 9 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 349200533758 &lt; 213〉 Human &lt; 220 &gt; &lt; 223 &gt; Probe 39327.at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222〉 73, 209, 211, 302, 306, 307, 393 &lt; 223 &gt; n is a, g, c or t &lt; 400> 348 ^ ggttccatca caagctatgt ttaaaaagaa aattggtgtt tggcaaacgg aacagaacct ttgatgagag cgnttcacag ggacactgtc tgggggtgca gtgcaagccc ccggcctctt ccctgggaac ctctgaactc ctccttcctc tgggctctct gtaacatttc accacacgtc agcatctaat cccaagacaa acattcccnc ntgctcgaag cagctgtata gcctgtgact ctccgtgtgt cagctccttc cacacctgat tagaacattc ataagccaca tttagaaaca gntttnnttt cagctgtcac ttgcacacat actgcctagt tgtgaaccaa atgtgaaaaa acctccttea tcccattgtg tatctgatac etneegaggg ccaagggtgt gtgttgacaa cgccgctccc agccggccct ggttgcgtcc acgtcctgaa caagagccgc tteeggatgg ctcttcccaa gggaggagga gctcaagtgt cgggaactgt ctaacttcag gttgtgtgag tgcgt &lt; 210 &gt; 349 &lt; 211 &gt; 417 &lt; 212> DNA &lt; 213 &gt; human 60 120 180 [240 300,360,420,480,540 545 98677.doc-282-200533758 &lt; 220 &gt; &lt; 223〉 Probe 39333—at HG-U95Av2 &lt; 220 & gt &lt; 221〉 misc-feature &lt; 222〉 (264) .. (278) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221 &gt; mi sc-feature &lt; 222〉 ( 345): (346) 9 &lt; 223 &gt; n is a, g, c or t &lt; 400> 349

60 120 180 240 300 360 417 gaatgacttg acttcaaaag caacaacctt aaaggccgtc atttcattag tattcctcat tctgcatcct ggcttgaaaa acagctctgt tgaatcacag tatcagtatt ttcacacgta agcacattcg ggccatttcc gtggtttctc atgagctgtg ttcacagacc tcagcagggc atcgcatgga ccgcaggagg gcagattcgg accactaggc ctgaaatgac atttcactaa aagtctccaa aacatttcta agannnnnnn nnnnnnnnat gtaatttctt taaatgtgta tttcttaaga attcaaattt gtaataaaac tatttgtata aaaannaagc ttttattaat ttgttgctag tattgccaca gacgcattaa aagaaactta ctgcacaagc tgctaat &lt;210〉 350 &lt;211&gt; 382 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 39397一at HG-U95Av2 98677.doc -283 - 200533758 &lt;220&gt; &lt;221〉 misc-feature &lt;222〉 （142)..(202) &lt;223&gt; η 為 a，g，c 或 t &lt;400〉 350 atttttaggt gaagtcgagc actctaatta gagaactgga ggaaccacat ataacactta acttccccta ccctgcccct ccccaaaaga aaccatgaca aacctagctt ttaaaaaata • ttttaagaaa gagaatgaac tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nngtgaactt ttgtaatttg aattgggtcc cgcttagttc ttgaattgtt atgaaaatcc tatatctgtt tgtatatttg caaacccttt gtattataat tgttgatatt ttcccttttt aaaaaatacc attgaaatca gcatgacaaa aataacactg ttggcactta taggtaacgt ga &lt;210&gt; 351 &lt;211&gt; 234 φ &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 393—s—at HG-U95Av2 &lt;400〉 351 atacctgttt ggggggaatg caacatattt ctttgggaca acatgtttgg tacatctgag ttccgtcctg gtcttttata cacaatgcct atgatttttt catgaaaatt ttttgtttac attggttggt tgtttgacaa cgtagcgtat ttttattttt taatctcaca acatttgttt 986^7.doc -284- 200533758 tgggattttt gtgtgtttgt tgggaatttt gtttttagcc aggtcagtat tgat &lt;210&gt; 352 &lt;211〉 550 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 39402.at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; (51, 123..139, 272..274, 301..369) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 352 aatgtggact caatccctag ggctggcaga aagggaacag aaaggttttt nagtacggct atagcctgga ctttcctgtt gtctacacca atgcccaact gcctgcctta gggtagtgct aannnnnnnn nnnnnnnnnc agccaggaca gtcagctctc tcctttcagg gccaatcccc agcccttttg ttgagccagg cctctctcac ctctcctact cacttaaagc ccgcctgaca60 120 180 240 300 360 417 gaatgacttg acttcaaaag caacaacctt aaaggccgtc atttcattag tattcctcat tctgcatcct ggcttgaaaa acagctctgt tgaatcacag tatcagtatt ttcacacgta agcacattcg ggccatttcc gtggtttctc atgagctgtg ttcacagacc tcagcagggc atcgcatgga ccgcaggagg gcagattcgg accactaggc ctgaaatgac atttcactaa aagtctccaa aacatttcta agannnnnnn nnnnnnnnat gtaatttctt taaatgtgta tttcttaaga attcaaattt gtaataaaac tatttgtata aaaannaagc ttttattaat ttgttgctag tattgccaca gacgcattaa aagaaactta ctgcacaagc tgctaat &lt; 210> 350 &lt; 211 &gt; 382 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 39397-at HG-U95Av2 98677.doc -283-200533758 &lt; 220 &gt; &lt; 221〉 misc -feature &lt; 222〉 (142) .. (202) &lt; 223 &gt; η is a, g, c, or t &lt; 400〉 350 atttttaggt gaagtcgagc actctaatta gagaactgga ggaaccacat ataacactta acttccccta ccctgcccct ccccaaaaaagannnn nnnntgatcatta nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nngtgaactt ttgtaatttg aattgggtcc cg cttagttc ttgaattgtt atgaaaatcc tatatctgtt tgtatatttg caaacccttt gtattataat tgttgatatt ttcccttttt aaaaaatacc attgaaatca gcatgacaaa aataacactg ttggcactta tag &lt; 220 &lt; lt &lt; 212 &lt; lt &lt; 212 at HG-U95Av2 &lt; 400> 351 atacctgttt ggggggaatg caacatattt ctttgggaca acatgtttgg tacatctgag ttccgtcctg gtcttttata cacaatgcct atgatttttt catgaaaatt ttttgtttac attggttggt tgtttgacaa cgtagcgtat ttttattttt taatctcaca acatttgttt 986 ^ 7.doc -284- 200533758 tgggattttt gtgtgtttgt tgggaatttt gtttttagcc aggtcagtat tgat &lt; 210 &gt; 352 &lt; 211 〉 550 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 39402.at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; (51, 123..139, 272..274, 301..369) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 352 aatgtggact caatccctag ggctggcaga aagggaacag aaaggttttt nagtacggct atagcctgga ctttcctgtt gtctacacca atgcccann gnncnn gnncnn gnn cagctctc tcctttcagg gccaatcccc agcccttttg ttgagccagg cctctctcac ctctcctact cacttaaagc ccgcctgaca

gaaaccacgg ccacatttgg ttctaagaaa cnnncctctg tcattcgctc ccacattctg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna agggggcaag aagtagcagt gtctgtaaaa gagcctagtt tttaatagct atggaatcaa ttcaatttgg actggtgtgc tctctttaaa tcaagtcctt taattaagac tgaaaatata taagctcaga ttatttaaat gggaatattt ataaatgagc aaatatcata ctgttcaatg 234gaaaccacgg ccacatttgg ttctaagaaa cnnncctctg tcattcgctc ccacattctg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna agggggcaag aagtagcagt gtctgtaaaa gagcctagtt tttaatagct atggaatcaa ttcaatttgg actggtgtgc tctctttaaa tcaagtcctt taattaagac tgaaaatata taagctcaga ttatttaaat gggaatattt ataaatgagc aaatatcata ctgttcaatg 234

60 120 180 240 300 360 420 480 540 98677.doc -285 - 55060 120 180 240 300 360 420 480 540 98677.doc -285-550

200533758 &lt;210&gt; 353 &lt;211&gt; 481 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;222» Probe 39409^at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature &lt;222&gt; (262..285, 295..297, 302, 304..311, 313, 315..350) • &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 353 ctggacaccc atctctaaag caggacgcct gccaggggga tagtgggggc gtttttgcag taagggaccc gaacactgat cgctgggtgg ccacgggcat cgtgtcctgg ggcatcgggt gcagcagggg ctatggcttc tacaccaaag tgctcaacta cgtggactgg atcaagaaag agatggagga ggaggactga gcccagaatt cactaggttc gaatccagag agcagtgtgg aaaaaaaaaa acaaaaaaca annnnnnnnn nnnnnnnnnn nnnnnagagt ctctnnnaaa antnnnnnnn nanannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttgatgtact ttacctgaaa caacccaaag ggcccctttc tttcttctga ggattgcaga ggatatagtt atcaatctct agttgtcact ttcctcttcc actttgatac cattgggtca ttgaatataa200533758 &lt; 210 &gt; 353 &lt; 211 &gt; 481 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 222 »Probe 39409 ^ at HG-U95Av2 &lt; 220> &lt; 221〉 misc-feature &lt; 222 &gt; (262..285, 295..297, 302, 304..311, 313, 315..350) • &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 353 ctggacaccc atctctaaag caggacgcct gccaggggga tagtgggggc gtttttgcag taagggaccc gaacactgat cgctgggtgg ccacgggcat cgtgtcctgg ggcatcgggt gcagcagggg ctatggcttc tacaccaaag tgctcaacta cgtggactgg atcaagaaag agatggagga ggaggactga gcccagaatt cactaggttc gaatccagag agcagtgtgg aaaaaaaaaa acaaaaaaca annnnnnnnn nnnnnnnnnn nnnnnagagt ctctnnnaaa antnnnnnnn nanannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ttgatgtact ttacctgaaa caacccaaag ggcccctttc tttcttctga ggattgcaga ggatatagtt atcaatctct agttgtcact ttcctcttcc actttgatac cattgggtca ttgaatataa

&lt;210&gt; 354 &lt;211&gt; 411 &lt;212〉 DNA 60 120 180 240 300 360 420 480 481 986,7.doc - 286- 200533758 &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 39421—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （263)..(278) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 • &lt;221&gt; misc一feature &lt;222〉 （31).,(46) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 354 gacggtataa cacatctact gaaaaagcaa nnnnnnnnnn nnnnnnattt aagccagccc ccacctaggg tctatttgtg tggcagttat tgggtttggt cacaaaacat cctgaaaatt cgtgcgtggg cttctttctc cctggtacaa acgtatggaa tgcttcttaa aggggaactg tcaagctggt gtcttcagcc agatgacatg agagaatatc ccagaaccct ctctccaagg&lt; 210 &gt; 354 &lt; 211 &gt; 411 &lt; 212> DNA 60 120 180 240 300 300 360 420 480 481 986,7.doc-286- 200533758 &lt; 213 &gt; Human &lt; 220〉 &lt; 223〉 Probe 39421-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (263) .. (278) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 • &lt; 221 &gt; misc-feature &lt;. 222> (31), (46) &lt; 223 &gt; n is a, g, c or t &lt; 400> 354 gacggtataa cacatctact gaaaaagcaa nnnnnnnnnn nnnnnnattt aagccagccc ccacctaggg tctatttgtg tggcagttat tgggtttggt cacaaaacat cctgaaaatt cgtgcgtggg cttctttctc cctggtacaa acgtatggaa tgcttcttaa aggggaactg tcaagctggt gtcttcagcc agatgacatg agagaatatc ccagaaccct ctctccaagg

60 120 180 240 300 360 411 tgtttctaga tagcacagga gannnnnnnn nnnnnnntcc acagtccacg gtacacagtc gggtgggccg cctcccctct cctgggagca ttcgtcgtgc ccagcctgag cagggcagct ggactgctgc tgttcaggag ccaccagagc cttcctctct ttgtaccaca g &lt;210&gt; 355 &lt;211〉 433 &lt;212&gt; DNA &lt;213&gt; 人類 98677.doc 28-7 - 200533758 &lt;220&gt; &lt;223&gt; Probe 39517^at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （145)..(167) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; (169)..(170) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （326)..(327) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 355 tcttaggggt cattatcact taaataatac tgtacctagg tctttcaaat taaaattata cctgaatgaa gttgtttgta tacataaagg atatttgtgt acaattacct tttttccccc60 120 180 240 300 360 411 tgtttctaga tagcacagga gannnnnnnn nnnnnnntcc acagtccacg gtacacagtc gggtgggccg cctcccctct cctgggagca ttcgtcgtgc ccagcctgag cagggcagct ggactgctgc tgttcaggag ccaccagagc cttcctctct ttgtaccaca g &lt; 210 &gt; 355 &lt; 211> 433 &lt; 212 &gt; DNA &lt; 213 &gt; human 98677.doc 28- 7-200533758 &lt; 220 &gt; &lt; 223 &gt; Probe 39517 ^ at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222> (145) .. (167) &lt; 223 &gt; n is a, g, c Or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; (169) .. (170) &lt; 223 &gt; n is a, g, c or t &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 〉 (326) .. (327) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 355 tcttaggggt cattatcact taaataatac tgtacctagg tctttcaaat taaaattata cctgaatgaa gttgtttgta tacataaagg atatttgtgt acaattacct tttttc

acacttgttt tctttgtttt tgttnnnnnn nnnnnnnnnn nnnnnnntnn actatgggat tcatttatgt ctgtctttct atcataaaga attgatcaat atgtaaatat gtgatttgaa ccatggttga cttacaagtg tcactacagc tttttagaaa acatagccct aatatatgtt aagcaggacc cgggtgagcc agtggnnttg cgctttatgt agagctggaa gaaggccgtc catcctgtct cttgggcgga cagtgtactt tcctaatagg gaagggaagc acaatggaaa tacccctgaa ccg 98677.doc -288 ·acacttgttt tgttnnnnnn nnnnnnnnnn nnnnnnntnn actatgggat tcatttatgt ctgtctttct atcataaaga attgatcaat atgtaaatat gtgatttgaa ccatggttga cttacaagtg tcactacagc tttttagaaa acatagccct aatatatgtt aagcaggacc cgggtgagcc agtggnnttg cgctttatgt agagctggaa gaaggccgtc catcctgtct cttgggcgga cagtgtactt tcctaatagg gaagggaagc acaatggaaa tacccctgaa ccg 98677.doc -288 tctttgtttt ·

200533758 &lt;210&gt; 356 &lt;211&gt; 571 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 39532一at HG-U95Av2 &lt;220&gt; &lt;221&gt; mi sc一feature &lt;222〉 41..62, 82..84, 92， 109， 112, 118, 397..411 ^ &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 356 attgccaccc tgaaccagct ctgtgccacc aagttccgag nnnnnnnnnn nnnnnnnnnn nncctcttcc tgtacaagga gnnnggctac cnccgcctgc cccctgggnc cntggccnac aggctgccca ccactggcta cctcgtctac cgccgggcag agtggcctga gacccagggg gctgtgacag aggaggaggg cagtgggcag tcagaggcaa gaagcagagg ggaggagcaa gggtgccagg gagatgggga tgctggggtc aaagccagcc ccagggacat tcgggaacag tctgagacaa ctgctgaagg gggccagggt caagcccagg aaggccctgc tcagccaggg gaaccagagg cagagggaag ccgggcagca gaggagnnnn nnnnnnnnnn nagaagggtc attcggggcg ggagaccctg agcctgctga gaaatccttt tagcgccagc aagccccacc cagggccctg tcctgtgtct gccaccacct ttgtctgata cttgtttcca gggaagctgg gggaactgcc acatctgagg aactggaata a &lt;210&gt; 357 60 120 180 240 300 360 420 480 540 98677.doc -289- 571 200533758 &lt;211〉 511 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 39579—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (286)..(301) &lt;223〉n 為 a，g，c 或 t200533758 &lt; 210 &gt; 356 &lt; 211 &gt; 571 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220 &gt; &lt; 223> Probe 39532-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222〉 41..62, 82..84, 92, 109, 112, 118, 397..411 ^ &lt; 223> n is a, g, c or t &lt; 400 &gt; 356 attgccaccc tgaaccagct ctgtgccacc aagttccgag nnnnnnnnnnnn nnnnnnnnnnnnncnccttcc tgtacaagga gnnnggctac cnccgcctgc cccctgggnc cntggccnac aggctgccca ccactggcta cctcgtctac cgccgggcag agtggcctga gacccagggg gctgtgacag aggaggaggg cagtgggcag tcagaggcaa gaagcagagg ggaggagcaa gggtgccagg gagatgggga tgctggggtc aaagccagcc ccagggacat tcgggaacag tctgagacaa ctgctgaagg gggccagggt caagcccagg aaggccctgc tcagccaggg gaaccagagg cagagggaag ccgggcagca gaggagnnnn nnnnnnnnnn nagaagggtc attcggggcg ggagaccctg agcctgctga gaaatccttt tagcgccagc aagccccacc cagggccctg tcctgtgtct gccaccacct ttgtctgata cttgtttcca gggaagctgg gggaactgcc acatctgagg aactggaata a &lt; 210 &gt; 357 60 120 180 240 300 300 420 480 540 98677.doc -289- 571 200533758 &lt; 211〉 511 &lt; 212〉 DNA &lt; 213〉 Human &lt; 220 &gt; &lt; 223〉 Probe 39579-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; (286) .. (301) &lt; 223> n is a, g, c or t

&lt;400〉 357 attcatactg aacggaattc tattggatgg atctgacaac tcggacaaag naaaaatgct gcgaactgtt tttaaaatat agttatatac tcagggctgt tttgatcctc gcaggagcct aacaaaacac tatcatggtg tatgtctaaa cacaaaatga gcatttgaag taatcatttt gctcaatgac tctttgttga cactgtgcat ccagatacac gagaagattt agagctcgct tcccatcaag catctgttga ctgttgtggc tggatgttcc gcaaaagtat aattggtggt atacaacggg taaaacaaca ggcaagctgc gccctcccat ttgtatggat t ctatatgcaa gaattaggag gtcatatttt gccacatctg aacccnnnnn ctcttgagtt aattaacact gtaagtgttc acaaaatcac ccgctctgtt gcttttcaat tcatgtcttc nnnnnnnnnn tgt tataaaa caaaactatt ttacatagtt 60 120 180 240 300 360 420 480 511 &lt;210&gt; 358 &lt;211&gt; 556 &lt;212〉 DNA &lt;213〉人類 98677.doc -290-&Lt; 400> 357 attcatactg aacggaattc tattggatgg atctgacaac tcggacaaag naaaaatgct gcgaactgtt tttaaaatat agttatatac tcagggctgt tttgatcctc gcaggagcct aacaaaacac tatcatggtg tatgtctaaa cacaaaatga gcatttgaag taatcatttt gctcaatgac tctttgttga cactgtgcat ccagatacac gagaagattt agagctcgct tcccatcaag catctgttga ctgttgtggc tggatgttcc gcaaaagtat aattggtggt atacaacggg taaaacaaca ggcaagctgc gccctcccat ttgtatggat t ctatatgcaa gaattaggag gtcatatttt gccacatctg aacccnnnnn ctcttgagtt aattaacact gtaagtgttc acaaaatcac ccgctctgtt gcttttcaat tcatgtcttc nnnnnnnnnn tgt tataaaa caaaactatt ttacatagtt 60 120 180 240 300 360 420 480 511 &lt; 210 &gt; 358 &lt; 211 &gt; 556 &lt; 212〉 DNA &lt; 213〉 Human 98677.doc -290-

200533758 &lt;220&gt; &lt;223〉 Probe 39633—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; 26, 28, 30.·44, 60, 201， 213, 229, 232, 272, 440 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 358 gacaaataca agctctgcca ggcggngntn nnnnnnnnnn nnnngaagga gctggccacn tggaccccga ctgagtttcg ggaatgtgac tacaacaaat tcatgagtgt tctggacacc aacaaggact gcgaggtgga ctttgtggag tatgtgcgct cacttgcctg cctctgtctc tactgccacg agtacttcaa nggactgccc ctncagagcc cccctgctnc cnagtagcct ctgctccagg gggtgcgctg gctgtcgggg gnctgggcat gtctcccaca ccccctccta ccctctctcc tgtacccctt tcaatctgga cttgcccagg tcttctgcga tcagttaacc cattttacct aggaggccca gagatgtgag ggctccttcc tcaggatgcc cagcgaatga ggggtagagc cactctgggn cccagcctgc ctgccgcacc cctgtggcct cccttgtgga tgggaggagg cgggatctgc tctgaggccc tcgaggctca gcagagcgtg caccaatgag accacgatgg gaaagg &lt;210〉 359 &lt;211&gt; 542 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 39640—at HG-U95Av2 60 120 180 240 300 360 420 480 540 556 98677.doc -291 -200533758 &lt; 220 &gt; &lt; 223〉 Probe 39633-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 26, 28, 30. · 44, 60, 201, 213, 229, 232, 272, 440 &lt; 223 &gt; n is a, g, c or t &lt; 400> 358 gacaaataca agctctgcca ggcggngntn nnnnnnnnnn nnnngaagga gctggccacn tggaccccga ctgagtttcg ggaatgtgac tacaacaaat tcatgagtgt tctggacacc aacaaggact gcgaggtgga ctttgtggag tatgtgcgct cacttgcctg cctctgtctc tactgccacg agtacttcaa nggactgccc ctncagagcc cccctgctnc cnagtagcct ctgctccagg gggtgcgctg gctgtcgggg gnctgggcat gtctcccaca ccccctccta ccctctctcc tgtacccctt tcaatctgga cttgcccagg tcttctgcga tcagttaacc cattttacct aggaggccca gagatgtgag ggctccttcc tcaggatgcc cagcgaatga ggggtagagc cactctgggn cccagcctgc ctgccgcacc cctgtggcct cccttgtgga tgggaggagg cgggatctgc tctgaggccc tcgaggctca gcagagcgtg caccaatgag accacgatgg gaaagg &lt; 210> 359 &lt; 211 &gt; 542 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 39640—at HG-U95Av2 60 120 180 240 300 360 420 480 540 556 98677.doc -291-

200533758 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 26, 53..55, 59, 60, 89， 129， 138, 144， 145， 159·.219, 344 &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 484..512 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 359 atacagctct cttcagagta actgtnaacc ttttataacc aacactagag ttnnntttnn aaaagacaag atatttataa tgacgactng tatagctttt aagttatttt tctagtatgt ggctttctnt agccgtgnta acgnncaaac tgttcatcnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna gcacaaggca ttggccctct ggactccttt ctccttttct ttcctctcta ggctgctcct gaatcctgtt ctctgacatc cgtggagccc ctcctgcatc cacctatgcc tcctataagt ccanttgaaa tctcagcctc cttcaacatt ttcttctcgt gtgtggccca catccctcca cttctccaac ttctgtttaa tctgatcacg gctcttttta agccctggca gcattttggt ccctgctcct tgcccatagt aaannnnnnn nnnnnnnnnn nnnnnnnnnn nnagtttcaa gtgggcaact ctgctctcta tt &lt;210&gt; 360 &lt;211&gt; 544 &lt;212&gt; DNA &lt;213&gt;人類 60 120 180 240 300 360 420 480 540 542 98677.doc 292- 200533758 &lt;220〉 &lt;223&gt; Probe 39663_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （113)..(176) &lt;223〉n 為 a，g，c 或 t200533758 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222〉 26, 53..55, 59, 60, 89, 129, 138, 144, 145, 159 · .219, 344 &lt; 223 &gt; n is a, g , C or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 484..512 &lt; 223 &gt; n is a, g, c or t &400; 359 atacagctct cttcagagta actgtnaacc ttttataacc aacactagag ttnnntttgat ataga ataagaa tctagtatgt ggctttctnt agccgtgnta acgnncaaac tgttcatcnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna gcacaaggca ttggccctct ggactccttt ctccttttct ttcctctcta ggctgctcct gaatcctgtt ctctgacatc cgtggagccc ctcctgcatc cacctatgcc tcctataagt ccanttgaaa tctcagcctc cttcaacatt ttcttctcgt gtgtggccca catccctcca cttctccaac ttctgtttaa tctgatcacg gctcttttta agccctggca gcattttggt ccctgctcct tgcccatagt aaannnnnnn nnnnnnnnnn nnnnnnnnnn nnagtttcaa gtgggcaact ctgctctcta tt &lt; 210 &gt; 360 &lt; 211 &gt; 544 &lt; 212 &gt; DNA &lt; 213 &gt; human 60 120 180 240 300 360 420 480 540 542 98677.doc 292- 200533758 &lt; 220 &Lt; 223 &gt; Probe 39663_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc a feature &lt; 222> (113) .. (176) &lt; 223> n is a, g, c or t

&lt;400&gt; 360 ggtcagttat tccaatggca nnnnnnnnnn gggcaatggg gttctctagc gaaactttta ttcacctccc attccgaatc tatacctttc tgag ccttctctcc aataagttct nnnnnnnnnn cactccaatg aaaggcacag aacaagttta ggcactcaga cagttgaggt ttggtttgac ttagccacat cctcacctac nnnnnnnnnn aggcagcctt ggctgttttg ttgtcgaaag atataagtga gaacctgact gtgcaataaa aacttcttct ccttgagctg nnnnnnnnnn gatcctccac ttctactact tctcacacct gatcaacttg ttcacatttg gaagcacatt ctcatgaatc caaggtgaat nnnnnnnnnn agaaaagggt cagggaaaga tcatcactat agtccaatgg gattgagaat attttagctt atccagtcat tcnnnnnnnn nnnnnnaggt ttgattgtcg tattggtaca ccttgatgca aaatcagcac cattggcttt ctggctactg 60 120 180 240 300 360 420 480 540 544 &lt;210〉 361 &lt;211&gt; 405 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 98677.doc - 293 - 200533758 &lt;223&gt; Probe 39680—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; 151..165, 331, 333, 359 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 361 60 120 ISO 240 300 360 405 gtctcatctt gagtaaaaga gaacccagcc aactatgaag ttccttgtct ttgccttcat cttggctctc atggtttcca tgattggagc tgattcatct gaagagaaat ttttgcgtagagtccaatgg gattgagaat 360 ggtcagttat tccaatggca nnnnnnnnnn gggcaatggg gttctctagc gaaactttta ttcacctccc attccgaatc tatacctttc tgag ccttctctcc nnnnnnnnnn cactccaatg aaaggcacag aacaagttta ggcactcaga cagttgaggt ttggtttgac ttagccacat cctcacctac nnnnnnnnnn aggcagcctt ggctgttttg ttgtcgaaag atataagtga gaacctgact gtgcaataaa aacttcttct ccttgagctg nnnnnnnnnn gatcctccac ttctactact tctcacacct gatcaacttg ttcacatttg gaagcacatt ctcatgaatc caaggtgaat nnnnnnnnnn agaaaagggt cagggaaaga tcatcactat aataagttct; &lt; 400 & gt attttagctt atccagtcat tcnnnnnnnn nnnnnnaggt ttgattgtcg tattggtaca ccttgatgca aaatcagcac cattggcttt ctggctactg 60 120 180 240 300 360 420 480 540 544 &lt; 210> 361 &lt; 211 &gt; 405 &lt; 212 &lt; 212> &lt; 212> &lt; 212> DNA & 677 200533758 &lt; 223 &gt; Probe 39680-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 151..165, 331, 333, 359 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 361 60 120 ISO 240 300 360 405 gtctcatctt gagtaaaaga gaacccagcc aactatgaag ttccttgtct t tgccttcat cttggctctc atggtttcca tgattggagc tgattcatct gaagagaaat ttttgcgtag

aattggaaga ttcggttatg ggtatggccc nnnnnnnnnn nnnnnagaac aaccactata cccacaacca taccaaccac aataccaaca atataccttt taatatcatc agtaactgca ggacatgatt attgaggctt gattggcaaa tacgacttct acatccatat tctcatcttt cataccatat cacactacta ccactttttg nangaatcat caaagagcaa tgcaaatgna aaacactata atttactgta tactctttgt ttcaggatac ttgcc &lt;210〉 362 # &lt;211&gt; 511 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 39681—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 63, 125..140, 157..171 &lt;223〉n 為 a，g，c 或 t 98677 d〇c •294- 60 200533758 &lt;400〉 362 tgcagcagca catggaggtc cacgcgggcg tgcgcagcta catctgcagt gagtgcaacc gcnccttccc cagccacacg gctctcaaac gccacctgcg ctcacataca ggcgaccacc cctannnnnn nnnnnnnnnn ggcagctgct tccgggnnnn nnnnnnnnnn nagagccaca aacgcatcca cacgggtgag aaaccctacg agtgcaatgg ctgtggcaag aagttcagcc tcaagcatca gctggagacg cactataggg tgcacacagg tgagaagccc tttgagtgta agctctgcca ccagcgctcc cgggactact cggccatgat caagcacctg agaacgcacaaattggaaga ttcggttatg ggtatggccc nnnnnnnnnn nnnnnagaac aaccactata cccacaacca taccaaccac aataccaaca atataccttt taatatcatc agtaactgca ggacatgatt attgaggctt gattggcaaa tacgacttct acatccatat tctcatcttt cataccatat cacactacta ccactttttg nangaatcat caaagagcaa tgcaaatgna aaacactata atttactgta tactctttgt ttcaggatac ttgcc &lt; 210> 362 # &lt; 211 &gt; 511 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223〉 Probe 39681—at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 63, 125..140, 157..171 &lt; 223> n is a, g, c or t 98677 d〇c • 294- 60 200533758 &lt; 400> 362 tgcagcagca catggaggtc cacgcgggcg tgcgcagcta catctgcagt gagtgcaacc gcnccttccc cagccacacg gctctcaaac gccacctgcg ctcacataca ggcgaccacc cctannnnnn nnnnnnnnnn ggcagctgct tccgggnnnn nnnnnnnnnn nagagccaca aacgcatcca cacgggtgag aaaccctacg agtgcaatgg ctgtggcaag aagttcagcc tcaagcatca gctggagacg cactataggg tgcacacagg tgagaagccc tttgagtgta agctctgcca ccagcgctcc cgggactact cggccatgat caagcacctg agaacgcaca

acggcgcctc gccctaccag tgcaccatct gcacagagta ctgccccagc ctctcctcca tgcagaagca catgaagggc cacaagcccg aggagatccc gcccgactgg aggatagaga agacgtacct ctacctgtgc tatgtgtgaa g &lt;210&gt; 363 &lt;211〉 331 &lt;212〉 DNA &lt;213&gt;人類 # &lt;220&gt; &lt;223&gt; Probe 39728—at HG-U95Av2 &lt;400〉 363 tgtgccctgg gtcaccgtca atgggaaacc cttggaagat cagacccagc tccttaccct tgtctgccag ttgtaccagg gcaagaagcc ggatgtctgc ccttcctcaa ccagctccct caggagtgtt tgcttcaagt gatggccggt gagctgcgga gagctcatgg aaggcgagtg ggaacccggc tgcctgcctt tttttctgat ccagaccctc ggcacctgct acttaccaac tggaaaattt tatgcatccc atgaagccca gatacacaaa attccacccc atgatcaaga 120 180 240 300 360 420 480 511 60 120 180 240 98677.doc -295 - 300 200533758 atcctgctcc actaagaatg gtgctaaagt a 331 &lt;210&gt; 364 &lt;211&gt; 456 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 39742—at HG-U95Av2 • &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 （143)..(143) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 364 ggaaaatcta gtttcacagc tatttgaatt tttttctgga tttactatat aactcttatt 60 ttttaaaaga tcattctgtt ctttcaagga gaaataagcc taaaagaaga aaaacaaaaa 120 aaattctgta taaaactgta atncctttgt attcatgttt acagtgctat tactataatt 180 鲁 caaaattatg tatgtgactt agagttatat aatcataatt tatgtttatt tcaaatatct 240 aagtttattg cttggatttc tagtgagagc tgttgaattt ggtgatgtca aatgtttcta 300 gggttttttt agtttgtttt tattgaaaaa tttaattatt tatgctatag gtgatattct 360 ctttgaataa acctataata gaaaatagca gacaacataa acatctttgt aaatatcaaa 420 cctaatacat ttcttgtcca gtgataaaac aactgg 456 &lt;210〉 365 &lt;211&gt; 207 98677.doc -296- 200533758 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 39781—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc—feature &lt;222&gt; 125, 157, 165, 168..177 &lt;223&gt; n 為 a，g，c 或 t • &lt;400〉 365 actcccctgg gcatcttctg gettgactgg atggaaggag acttaggaac ctaccagttg gccatgatgt cttttcttct ttttcttttt tttaacaaaa cagaacaaaa ccaaaaaatg tccanaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaanaaa aaaanaannn nnnnnnnatc cagtcaagcc atgatgtett ttettetacggcgcctc gccctaccag tgcaccatct gcacagagta ctgccccagc ctctcctcca tgcagaagca catgaagggc cacaagcccg aggagatccc gcccgactgg aggatagaga aga &&;; &lt;220; &lt;220; ltacctgtgc tatgtgtgaga &lt; &lt;210; &lt; 210 -U95Av2 &lt; 400> 363 tgtgccctgg gtcaccgtca atgggaaacc cttggaagat cagacccagc tccttaccct tgtctgccag ttgtaccagg gcaagaagcc ggatgtctgc ccttcctcaa ccagctccct caggagtgtt tgcttcaagt gatggccggt gagctgcgga gagctcatgg aaggcgagtg ggaacccggc tgcctgcctt tttttctgat ccagaccctc ggcacctgct acttaccaac tggaaaattt tatgcatccc atgaagccca gatacacaaa attccacccc atgatcaaga 120 180 240 300 360 420 480 511 60 120 180 240 98677 .doc -295-300 200533758 atcctgctcc actaagaatg gtgctaaagt a 331 &lt; 210 &gt; 364 &lt; 211 &gt; 456 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 39742-at HG-U95Av2 • &lt; 220> &lt; 221 &gt; mi sc-feature &lt; 222> (143) .. (143) &lt; 223 &gt; n is a, g, c or t &lt; 400> 364 ggaaaatcta gtttcaca gc tatttgaatt tttttctgga tttactatat aactcttatt 60 ttttaaaaga tcattctgtt ctttcaagga gaaataagcc taaaagaaga aaaacaaaaa 120 aaattctgta taaaactgta atncctttgt attcatgttt acagtgctat tactataatt 180 Lu caaaattatg tatgtgactt agagttatat aatcataatt tatgtttatt tcaaatatct 240 aagtttattg cttggatttc tagtgagagc tgttgaattt ggtgatgtca aatgtttcta 300 gggttttttt agtttgtttt tattgaaaaa tttaattatt tatgctatag gtgatattct 360 ctttgaataa acctataata gaaaatagca gacaacataa acatctttgt aaatatcaaa 420 cctaatacat ttcttgtcca gtgataaaac aactgg 456 &lt; 210〉 365 &lt; 211 &gt; 207 98677.doc -296- 200533758 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220〉 &lt; 223 &gt; Probe 39781-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc—feature &lt; 222 &gt; 125, 157, 165, 168..177 &lt; 223 &gt; n is a, g, c or t • &lt; 400〉 365 actcccctgg gcatcttctg gettgactgg atggaaggag acttaggaac ctaccagtttt gccatgattttt cta cagaacaaaa ccaaaaaatg tccanaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaanaaa aaaanaannn nnnnnnnatc cagtcaagcc atgat gtett ttettet

&lt;210&gt; 366 &lt;211&gt; 414 &lt;212&gt; DNA Φ &lt;2丨3&gt;人類 &lt;220〉 &lt;223〉 Probe 39791—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc^feature &lt;222&gt; 86, 95, 97..104, 120..137, 147, 148, 164..194, 307..350 &lt;223〉n 為 a, g, c 或 t &lt;400〉 366 gtaacagaca ttgttttgcc aacattgcct atttcagtgg cacgtcatct agttttaaaa 98677.doc -297- 200533758 aaataaaaca ttttaaatgg nnnnnnnnnn nnnnnnngac nnnnnnnnnn nnnnagttgt ggtagtcata ggaattgtat tttatgnnnn nnnnnnnnnn tatgtgtgtg ttttgtaaaa acaganaaaa aaaanannnn atgtccnnct ttctctccag actctgcttg aggggaagaa tcttaatgta caggcactaa nnnnnnnnnn nnnnnnnnnn tctgtaaata gcacatgacc nnnntttaac tcgtaagtgn ttcnnnnnnn nnnnnnnnnn ggctcctgct ctgctgtgta ttgtcatctg tgatgtacat nnnnnnnnnn tatgtgtgtg aaatgaacat attg &lt;210&gt; 367 &lt;211〉 432 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 39805—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc—feature&lt; 210 &gt; 366 &lt; 211 &gt; 414 &lt; 212 &gt; DNA Φ &lt; 2 丨 3 &gt; human &lt; 220〉 &lt; 223〉 Probe 39791-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 86, 95, 97..104, 120..137, 147, 148, 164..194, 307..350 &lt; 223〉 n is a, g, c or t &lt; 400〉 366 gtaacagaca ttgttttgcc aacattgcct atttcagtgg cacgtcatct agttttaaaa 98677.doc -297- 200533758 aaataaaaca ttttaaatgg nnnnnnnnnn nnnnnnngac nnnnnnnnnn nnnnagttgt ggtagtcata ggaattgtat tttatgnnnn nnnnnnnnnn tatgtgtgtg ttttgtaaaa acaganaaaa aaaanannnn atgtccnnct ttctctccag actctgcttg aggggaagaa tcttaatgta caggcactaa nnnnnnnnnn nnnnnnnnnn tctgtaaata gcacatgacc nnnntttaac tcgtaagtgn ttcnnnnnnn nnnnnnnnnn ggctcctgct ctgctgtgta ttgtcatctg tgatgtacat nnnnnnnnnn tatgtgtgtg aaatgaacat attg &lt; 210 &gt; 367 &lt; 211> 432 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 39805-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature

&lt;222&gt; 49..169, 172, 178, 221, 222, 228, 230 &lt;223&gt; n 為 a，g, c 或 t &lt;4〇0&gt; 367 aggcatccat nnnnnnnnnn nnnnnnnnnn ggccatccag acaggctctc gatgccatta nnnnnnnnnn nnnnnnnnnn gcttctctgg aactgtggtc tggctttccc nnnnnnnnnn nnnnnnnnnn ccaaagtctg aatgctgacc tgaagggtac nnnnnnnnnn nnnnnnnnnn tgccaaccgc agatcctcgt aggacacann nnnnnnnnnn nnnnnnnnnt nnccaccntn catcaaggat nnnnnnnnnn nnnnnnnnnn cnaatganag gtagtggcac ggctgcatcg 98677.doc - 298 - 200533758 tggagagggg acgacacgag gctctgttgt cccgaggtgg ggtgtatgct gacatgtggc agctgcagca gggacaggaa gaaacctctg aagacactaa gcctcagacc atggaacggt gacaaaagtt tg &lt;210&gt; 368 &lt;211&gt; 340 &lt;212〉 DNA &lt;213&gt;人類&lt; 222 &gt; 49..169, 172, 178, 221, 222, 228, 230 &lt; 223 &gt; n is a, g, c or t &lt; 4〇0 &gt; 367 aggcatccat nnnnnnnnnnnn nnnnnnnnnn ggccatccag acaggctctc gatgccatta nnnnnnnnnnnngtngg tggctttccc nnnnnnnnnn nnnnnnnnnn ccaaagtctg aatgctgacc tgaagggtac nnnnnnnnnn nnnnnnnnnn tgccaaccgc agatcctcgt aggacacann nnnnnnnnnn nnnnnnnnnt nnccaccntn catcaaggat nnnnnnnnnn nnnnnnnnnn cnaatganag gtagtggcac ggctgcatcg 98677.doc - 298 - 200533758 tggagagggg acgacacgag gctctgttgt cccgaggtgg ggtgtatgct gacatgtggc agctgcagca gggacaggaa gaaacctctg aagacactaa gcctcagacc atggaacggt gacaaaagtt tg &lt; 210 &gt; 368 &lt; 211 &gt; 340 &lt; 212〉 DNA &lt; 213 &gt; human

&lt;220〉 &lt;223&gt; Probe 39826—f—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 95..127, 142, 145, 146, 148, 150..152, 157, 161..163, 166 &lt;223&gt; n 為 a, g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 167， 172·.174， 177， 180， 182， 183， 185， 187， 191， 194， 196 &lt;223〉n 為 a，g，c 或 t&lt; 220> &lt; 223 &gt; Probe 39826—f-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 95..127, 142, 145, 146, 148, 150..152, 157, 161..163, 166 &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 167, 172 · .174, 177, 180, 182, 183, 185, 187 , 191, 194, 196 &lt; 223> n is a, g, c or t

&lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 203, 241， 243, 253, 283, 303 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 368 cttaaacgca gctgccaggt gtaatttttc aagtgtcaaa gatcccaagt gatccctgac acccacccct tcctactctt acattcatgc gtctnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntgc tccgatcaga anaannanan nnaaaanaac nnncanncac annnggnccn 98677.doc -299 - 200533758 tnnanancag naananacac aanccacctc cacgacctcc gacctccccc ctccctccgg ntngctctga ggnagcacgt gcctcttcct tcaccctggg ccnggctggg gcgggagcag ccnagctgct ctctggatgt cacaccactg ttaactgtca &lt;210&gt; 369 &lt;211〉 583 &lt;212〉 DNA &lt;213&gt;人類&lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> 203, 241, 243, 253, 283, 303 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 368 cttaaacgca gctgccaggt gtaatttttc aagtgtcaaa gatcctact gatcctact acattcatgc gtctnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntgc tccgatcaga anaannanan nnaaaanaac nnncanncac annnggnccn 98677.doc -299 - 200533758 tnnanancag naananacac aanccacctc cacgacctcc gacctccccc ctccctccgg ntngctctga ggnagcacgt gcctcttcct tcaccctggg ccnggctggg gcgggagcag ccnagctgct ctctggatgt cacaccactg ttaactgtca &lt; 210 &gt; 369 &lt; 211> 583 &lt; 212> DNA &lt; 213 &gt; Human

&lt;220〉 &lt;223〉 Probe 39878—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc__feature &lt;222〉 86..124， 148·.151， 159， 164， 167， 169， 170， 174..176 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 178, 179, 182..189, 191..198, 214..217, 220, 229, 231 &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc一feature &lt;222&gt; 276, 286, 330..347, 474..511, 515..518 &lt;223〉n 為 a，g，c 或 t &lt;400〉 369 atggatgtca atgacaccag cccagttgtc atttctccac cgtctaatac ttcctttaag ttggtgcccc tctcagccat tcctgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnctggaa tgaacgctga actaaagnnn nctatagtna gtgnaancnn taannncnna 98677.doc -3〇0 - 200533758&lt; 220> &lt; 223> Probe 39878-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc__feature &lt; 222> 86..124, 148 · .151, 159, 164, 167, 169, 170, 174. .176 &lt; 223> n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 178, 179, 182..189, 191..198, 214..217, 220, 229 , 231 &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222 &gt; 276, 286, 330..347, 474..511, 515..518 &lt; 223> n is a, g, c or t &lt; 400> 369 atggatgtca atgacaccag cccagttgtc atttctccac cgtctaatac ttcctttaag ttggtgcccc tctcagccat tcctgnnnnn nnnnnnnncncnctnctnctnactnactnactnactnactnactnactnactnactnactnactnactnactnactnactnactnctnactnactnactnactnactnactnactnactnactnactnactnactnactnactnactnctnctna

tnnnnnnnng nnnnnnnnac aggtaacatt actnnnnaan aaaaaccanc ncctactgat 240 gtgggattgc atcgtttggt ggtcaacata agtgancctg gggtanccct aagtctttgc 300 acacgcttgt gettgtattc ctttatgttn nnnnnnnnnn nnnnnnngcc tcctatatct 360 atgaettgat ccgcaggact atggagaccc cgttggacag gaacataggg gatagtagee 420 aaccctatca aaatgaggac tatctaacca teatgattge catcatcgcc ggtnnnnnnn 480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nggtnnnntg tcgccatgca tcaaggttca 540 aageagetea gaggagcaag caaggtgccg aatggatgtc ccc 583 &lt;210&gt; 370 &lt;211〉 268 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 39959„at HG-U95Av2 &lt;400〉 370 cttatggeat tgacaaagag aagaccatcc accttaccct gaaagtggtg aagcccagtg 60 atgaggaget gcccttgttt cttgtggagt caggtgatga ggcaaagagg cacctcctcc 120 aggtgcgaag gtccagctca gtggcacaag tgaaagcaat gatcgagact aagacgggta 180 taatccctga gacccagatt gtgaettgea atggaaagag actggaagat gggaagatga 240 tggeagatta cggcatcaga aagggcaa 268 &lt;210〉 371 &lt;211〉 331 98677.doc -30!- 200533758 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 39966_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （99)..(100) &lt;223&gt; η 為 a，g，c 或 ttnnnnnnnng nnnnnnnnac aggtaacatt actnnnnaan aaaaaccanc ncctactgat 240 gtgggattgc atcgtttggt ggtcaacata agtgancctg gggtanccct aagtctttgc 300 acacgcttgt gettgtattc ctttatgttn nnnnnnnnnn nnnnnnngcc tcctatatct 360 atgaettgat ccgcaggact atggagaccc cgttggacag gaacataggg gatagtagee 420 aaccctatca aaatgaggac tatctaacca teatgattge catcatcgcc ggtnnnnnnn 480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nggtnnnntg tcgccatgca tcaaggttca 540 aageagetea gaggagcaag caaggtgccg aatggatgtc ccc 583 &lt; 210 &gt; 370 &lt; 211〉 268 &lt; 212 &gt; DNA &lt; 213〉 human &lt; 220 &gt; &lt; 223 &gt; Probe 39959 „at HG-U95Av2 &lt; 400> 370 cttatggeat tgacaaagag aagaccatcc accttaccct gaaagtggtg aagcccagtgggtggt actcctgtggt cacctcctcc 120 aggtgcgaag gtccagctca gtggcacaag tgaaagcaat gatcgagact aagacgggta 180 taatccctga gacccagatt gtgaettgea atggaaagag actggaagat gggaagatga 240 tggeagatta cggcatcaga aagggcaa 268 &lt; 210> 371 &lt; 211> 331 98677.doc -30 - 200533758 &lt;! 212 &gt; DNA &lt; 213 &gt; Class &lt; 220 &gt; &lt; 223> Probe 39966_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc a feature &lt; 222> (99) .. (100) &lt; 223 &gt; η is a, g, c or t

&lt;400&gt; 371 60 120 180 240 300 331 caggctgact tggatgtgaa ctgtcttcag aataatttaa cctaaagcag agcaagaaga gaggaagcgg gggtagtggg tggggggtag gggaagaann attatctcct cttgtacaga gtctatttct tgtaaccatt tgttaaactc ttttcttttt ctgatctcat ggcatgcttt tatgtatttt gtacaggagg caaaaaaaat acttaaaata agcaaagaaa ctgaacagaa ttgcatacat tgggttgttt tttctgtgct gtctgtacat tgcttctgct gctgtgattt ctaaacctgt gctgttattc aactgacttt t &lt;210〉 372 &lt;211&gt; 387 &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 40049—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc__feature &lt;222〉 （141)..(141) &lt;223〉n 為 a，g，c 98677.doc - 302 - 200533758 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （216)·.(216) &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （234)..(253) &lt;223〉n 為 a，g，c 或 t&Lt; 400 &gt; 371 60 120 180 240 300 331 caggctgact tggatgtgaa ctgtcttcag aataatttaa cctaaagcag agcaagaaga gaggaagcgg gggtagtggg tggggggtag gggaagaann attatctcct cttgtacaga gtctatttct tgtaaccatt tgttaaactc ttttcttttt ctgatctcat ggcatgcttt tatgtatttt gtacaggagg caaaaaaaat acttaaaata agcaaagaaa ctgaacagaa ttgcatacat tgggttgttt tttctgtgct gtctgtacat tgcttctgct gctgtgattt ctaaacctgt gctgttattc aactgacttt t &lt; 210> 372 &lt; 211 &gt; 387 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 40049-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc__feature &lt; 222> (141): (141) ) &lt; 223> n is a, g, c 98677.doc-302-200533758 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> (216) .. (216) &lt; 223 &gt; η is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 (234) .. (253) &lt; 223> n is a, g, c or t

&lt;400&gt; 372 cctccagggt gattttatga tcagtgttgt tgctctagga agacattttt ccgtttgctt ttgttccaat gtcaatgtga acgtccacat gaaacctaca cactgtcatg cttcatcatt ccctctcatc tcaggtagaa nggttgacac agttgtaggg ttacagagac ctatgtaaga attcagaaga cccctgactc atcatttgtg gcagtnccct tataattggt gcannnnnnn nnnnnnnnnn nnnttagate ctggtttcat aacttcctgt acttgaagtc taaaagcaga aaataaagga agcaagtttt cttccatgat tttaaattgt gatcgagttt taaattgata ggagggaaca tgtcctaatt cttctgt &lt;210〉 373 &lt;211〉 416 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40051_at HG-U95Av2 60 120 180 240 300 360 387 98677.doc - 303 - 200533758 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （109)..(109) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; raise一feature &lt;222&gt; (116)..(116) &lt;223〉n 為 a，g，c 或 t&Lt; 400 &gt; 372 cctccagggt gattttatga tcagtgttgt tgctctagga agacattttt ccgtttgctt ttgttccaat gtcaatgtga acgtccacat gaaacctaca cactgtcatg cttcatcatt ccctctcatc tcaggtagaa nggttgacac agttgtaggg ttacagagac ctatgtaaga attcagaaga cccctgactc atcatttgtg gcagtnccct tataattggt gcannnnnnn nnnnnnnnnn nnnttagate ctggtttcat aacttcctgt acttgaagtc taaaagcaga aaataaagga agcaagtttt cttccatgat tttaaattgt gatcgagttt taaattgata ggagggaaca tgtcctaatt cttctgt &lt; 210> 373 &lt; 211> 416 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 40051_at HG-U95Av2 60 120 180 240 300 360 387 98677.doc-303-200533758 &lt; 220> &lt; 221 &gt; misc A feature &lt; 222> (109) .. (109) &lt; 223> n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; raise a feature &lt; 222 &gt; (116) .. (116) &lt; 223> n is a, g, c or t

&lt;400〉 373 tcattgtcca gcactctaga aggtggagag tttccttggg cctctgttta taatgcaaat tcaacaagga ggaataagat getaettgtt ccctgttcac tacagatttg aaaaaacatc gtggacaaag actcaaggaa tggcgtggtg cacgtggaga ctgatagggt agtgttcatg tgaaggatga tgtctgtttt aatttgtacc cccatgacat ggaaggatat ctagctgtga tgatgagact actaaggctg ctactctagc tgeegtattt caccgtcact tttgcgaanc cagtaaatat gtaaacctca ctggtgccct ctgttcatat atgctttcat ctgcctaaaa aacagnccgc aataccgctg tttttcggtt gagcaactga ggaccaaatt gtaaaa 60 120 180 240 300 360 416 &lt;210〉 374 &lt;211&gt; 594 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40069_at HG-U95Av2 &lt;220〉 &lt;221〉 misc—feature 98677.doc 60 60&Lt; 400> 373 tcattgtcca gcactctaga aggtggagag tttccttggg cctctgttta taatgcaaat tcaacaagga ggaataagat getaettgtt ccctgttcac tacagatttg aaaaaacatc gtggacaaag actcaaggaa tggcgtggtg cacgtggaga ctgatagggt agtgttcatg tgaaggatga tgtctgtttt aatttgtacc cccatgacat ggaaggatat ctagctgtga tgatgagact actaaggctg ctactctagc tgeegtattt caccgtcact tttgcgaanc cagtaaatat gtaaacctca ctggtgccct ctgttcatat atgctttcat ctgcctaaaa aacagnccgc aataccgctg tttttcggtt gagcaactga ggaccaaatt gtaaaa 60 120 180 240 300 360 416 &lt; 210〉 374 &lt; 211 &gt; 594 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 40069_at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc-feature 98677. doc 60 60

200533758 &lt;222&gt; 29, 438..467, 478..493, 539, 541, 552..555 &lt;223&gt; η 為 a, g，c 或 t &lt;400〉 374 ctgccttctt gttccagcta ggcaatgcnt tttttttttt ttttgaagca gttctcttta taaagtgtta ttttgatagt ttgtggattc taaaatatat atatatttat ataaacacca tataagtcaa atatgtattt aacaaagcaa tatgtattca ttcactttca agatttgttt tggtgtcaaa ataacatgaa aaggtagatg gagttgcttc tgttgaatta gctctgccac caatatgtat cttcatacac gtttggaaat gtttcctgca gcattaggta tgacttgttc tgagtactgc ttccggtgct aaaatgaaca aagaatttgt acttaatggc atggactctg gagaatctat gcgaatcaac ctttctacct taatatctcc ccaaaaatgt atagtgcctt gtttttatgt acagtttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnatg atggtttnnn nnnnnnnnnn nnnttttact ctcaaatagt caaaataaaa acatctcaat ttctaatanc ngttgtaaac annnngtaca catgtcattt tgtgatatag gactcccaaa taaa &lt;210〉 375 &lt;211&gt; 554 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 40088一at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 58..75, 78, 79, 81..85, 85..91, 93 &lt;223〉 n 為 a, g, c 或 t 120 180 240 300 360 420 480 540 594 98677.doc - 305 - 200533758 &lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; 94, 97..120, 122..125, 151..214 &lt;223&gt; η 為 a，g，c 或 t200533758 &lt; 222 &gt; 29, 438..467, 478..493, 539, 541, 552..555 &lt; 223 &gt; η is a, g, c or t &400; 374 ctgccttctt gttccagcta ggcaatgcnt tttttttttt ttttgaagca gttcttta ttttgatagt ttgtggattc taaaatatat atatatttat ataaacacca tataagtcaa atatgtattt aacaaagcaa tatgtattca ttcactttca agatttgttt tggtgtcaaa ataacatgaa aaggtagatg gagttgcttc tgttgaatta gctctgccac caatatgtat cttcatacac gtttggaaat gtttcctgca gcattaggta tgacttgttc tgagtactgc ttccggtgct aaaatgaaca aagaatttgt acttaatggc atggactctg gagaatctat gcgaatcaac ctttctacct taatatctcc ccaaaaatgt atagtgcctt gtttttatgt acagtttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnatg atggtttnnn nnnnnnnnnn nnnttttact ctcaaatagt caaaataaaa acatctcaat ttctaatanc ngttgtaaac annnngtaca catgtcattt tgtgatatag gactcccaaa taaa &lt; 210〉 375 &lt; 211 &gt; 554 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 40088-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt;; 58..75, 78, 79, 81..85, 85..91, 93 &lt; 223〉 n is a, g, c or t 120 180 240 300 360 420 480 540 594 98677.doc-305-200533758 &lt; 220〉 &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 94, 97..120, 122..125, 151..214 &lt; 223 &gt; η is a, g, c or t

&lt;400〉 375 atgtatacag nnnnnnnnnn tnnnnacaaa nnnnnnnnnn ttttaatcgt taatcccatt cacattacca tcagtaatat ctgtacatac ctgcagtgaa ttgcaagtct nnnnnaanng tcagatcaga nnnnnnnnnn caaccacttt gcaaacatta ttcatagtaa aatttgccat tgcagtgtga tttg ggacaaatgt nnnnngggnn tgttcatcct nnnnnnnnnn taaacataaa ttccaagagt gaattctggt ttttattaga atttttttgt atagaataaa ncnntgnnnn nnnnnnnnnn nnnnttgatt gaattcacac atcccagtat gtttacacaa aatttaattt tttgtttttt ccttttattt nnnnnnnnnn nnnnnnnnnn cgaagggtct aactactttc tagcaatact ccaaatttga cttcatgtga aatcttttag aagttgtnnn nnnnnnnnnn nnnnnnnnnn taaagaattt atgaattttt ggaatatagg tgcgatctgc tgtcatgaaa tgtttacttc 60 120 180 240 300 360 420 480 540 554 &lt;210&gt; 376 &lt;211〉 403 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 40091_at HG-U95Av2 98677.doc • 7〇6 - &lt;220&gt;&Lt; 400> 375 atgtatacag nnnnnnnnnn tnnnnacaaa nnnnnnnnnn ttttaatcgt taatcccatt cacattacca tcagtaatat ctgtacatac ctgcagtgaa ttgcaagtct nnnnnaanng tcagatcaga nnnnnnnnnn caaccacttt gcaaacatta ttcatagtaa aatttgccat tgcagtgtga tttg ggacaaatgt nnnnngggnn tgttcatcct nnnnnnnnnn taaacataaa ttccaagagt gaattctggt ttttattaga atttttttgt atagaataaa ncnntgnnnn nnnnnnnnnn nnnnttgatt gaattcacac atcccagtat gtttacacaa aatttaattt tttgtttttt ccttttattt nnnnnnnnnn nnnnnnnnnn cgaagggtct aactactttc tagcaatact ccaaatttga cttcatgtga aatcttttag aagttgtnnn nnnnnnnnnnnn nnnnnnnnnn taaagaattt atgaattttt ggaatatagg tgcgatctgc tgtcatgaaa tgtttacttc 60 120 180 240 300 360 420 480 540 554 &lt; 210 &gt; 376 &lt; 211> 403 &lt; ltlt212 40091_at HG-U95Av2 98677.doc • 7〇6-&lt; 220 &gt;

200533758 &lt;221&gt; misc一feature &lt;222〉 （275)..(309) &lt;223〉η 為 a，g，c 或 t &lt;400〉 376 aaaggctcga ttttgtatct gcaggcagac acggatctga gaatctttat tgagaaagag cacttaagag aatattttaa gtattgcatc tgtataagta agaaaatatt ttgtctaaaa tgcctcagtg tatttgtatt tttttgcaag tgaaggttta caatttacaa agtgtgtatt aaaaaaaaca aaaagaacaa aaaaatctgc agaaggaaaa atgtgtaatt ttgttctagt tttcagtttg tatatacccg tacaacgtgt cctcnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng cgagcgtgca ccatcccttt ttgaagtgta ggcagacaca gggacttgaa gttgttacta actaaactct ctttgggaat gtttgtctca tcc &lt;210&gt; 377 &lt;211&gt; 423 &lt;212〉 DNA &lt;213&gt;人類 60 120 180 240 300 360 403200533758 &lt; 221 &gt; misc-feature &lt; 222〉 (275) .. (309) &lt; 223〉 η is a, g, c or t &lt; 400> 376 aaaggctcga ttttgtatct gcaggcagac acggatctga gaatctttat tgagaaagag cacttaagag aatattatta tattatta tgcctcagtg tatttgtatt tttttgcaag tgaaggttta caatttacaa agtgtgtatt aaaaaaaaca aaaagaacaa aaaaatctgc agaaggaaaa atgtgtaatt ttgttctagt tttcagtttg tatatacccg tacaacgtgt cctcnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng cgagcgtgca ccatcccttt ttgaagtgta ggcagacaca gggacttgaa gttgttacta actaaactct ctttgggaat gtttgtctca tcc &lt; 210 &gt; 377 &lt; 211 &gt; 423 &lt; 212> DNA &lt; 213 &gt; human 60 120 180 240 300 360 403

&lt;223〉 Probe 40126—at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222&gt; (60)..(111) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc一feature &lt;222&gt; (176)..(220) 98677.doc -307 - 200533758 &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (229)..(246) &lt;223&gt; η 為 a，g，c 或 t &lt;400〉 377&lt; 223〉 Probe 40126-at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222 &gt; (60) .. (111) &lt; 223> n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222 &gt; (176) .. (220) 98677.doc -307-200533758 &lt; 223 &gt; η is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (229) .. (246) &lt; 223 &gt; η is a, g, c or t &lt; 400> 377

ttaattaggg atcttgctgc ttttcttttt ctacacgaag ttttcattaa agccacagan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nttaaatgaa ttagaaacta tttgaggcta taaaaatgtc cttgagtttg gagcctgagc tctggnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn agagtaagnn nnnnnnnnnn nnnnnntatc cgttcttcac ttagcaggaa tatgaaagaa aggcacatgt ttaagaggaa tacctaaagg tttttctaaa ttccaacatt taaaaggcaa ttgtgggcta tttttatttt ttaatatttt gaaataaagt ttagtgtcta gggctgggag ccaggactga tcttccattt cttttaattaggg atcttgctgc ttttcttttt ctacacgaag ttttcattaa agccacagan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nttaaatgaa ttagaaacta tttgaggcta taaaaatgtc cttgagtttg gagcctgagc tctggnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn agagtaagnn nnnnnnnnnn nnnnnntatc cgttcttcac ttagcaggaa tatgaaagaa aggcacatgt ttaagaggaa tacctaaagg tttttctaaa ttccaacatt taaaaggcaa ttgtgggcta tttttatttt ttaatatttt gaaataaagt ttagtgtcta gggctgggag ccaggactga tcttccattt ctt

&lt;210&gt; 378 &lt;211&gt; 483 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40153_at HG-U95Av2 &lt;400&gt; 378 ggtactcccg ctcagtgctt ctcatcaccc agcacctcag cctggtggag caggctgacc 98677.doc - 308 - 120 120&lt; 210 &gt; 378 &lt; 211 &gt; 483 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 40153_at HG-U95Av2 &lt; 400 &gt; 378 ggtactcccg ctcagtgctt ctcatcaccc agcacctcag cctgg cctgg -ctggg 120 120

200533758 acatcctctt tctggaagga ggcgctatcc gggagggggg aacccaccag cagctcatgg agaaaaaggg gtgctactgg gccatggtgc aggctcctgc agatgctcca gaatgaaagc cttctcagac ctgcgcactc catctccctc ccttttcttc tctctgtggt ggagaaccac agctgcagag taggcagctg cctccaggat gagttacttg aaatttgcct tgagtgtgtt acctcctttc caagctcctc gtgataatgc agacttcctg gagtacaaac acaggatttg taattcctta ctgtaacgga gtttagagcc agggctgatg ctttggtgtg gccagcactc tgaaactgag aaatgttcag aatgtacgga aagatgatca gctattttca acataactga agg &lt;210〉 379 &lt;211〉 129 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40171__at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （32)..(46) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 379 aatgtatgcg ccagggtgct tccgtggggc annnnnnnnn nnnnnnccat ccaagcccaa ggacctggga taaactggga gaactatggc agctacttgc atcgacttgt acctcactta gcccttggg 180 240 300 360 420 480 483 60 120 98677.doc - 309 - 129 200533758 &lt;210&gt; 380 &lt;211〉 210 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 40177_at HG-U95Av2 &lt;220〉200533758 acatcctctt tctggaagga ggcgctatcc gggagggggg aacccaccag cagctcatgg agaaaaaggg gtgctactgg gccatggtgc aggctcctgc agatgctcca gaatgaaagc cttctcagac ctgcgcactc catctccctc ccttttcttc tctctgtggt ggagaaccac agctgcagag taggcagctg cctccaggat gagttacttg aaatttgcct tgagtgtgtt acctcctttc caagctcctc gtgataatgc agacttcctg gagtacaaac acaggatttg taattcctta ctgtaacgga gtttagagcc agggctgatg ctttggtgtg gccagcactc tgaaactgag aaatgttcag aatgtacgga aagatgatca gctattttca acataactga agg &lt; 210> 379 &lt; 211> 129 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 40171__at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (32) .. (46) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 379 aatgtatgcg ccagggtgct tccgtggggc annnnnnnnn nnnnnnccat ccaagcccaa ggacctggga taaactggga gaactatggc agctacttgc atcgacttgt acct ct 120 cc 320 cc 420 380 &lt; 211〉 210 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Prob e 40177_at HG-U95Av2 &lt; 220〉

&lt;221〉 misc_feature &lt;222〉 （126)..(142) &lt;223&gt; n 為 a, g，c 或 t &lt;400&gt; 380 atattatact aattccatta gaaatnnnnn agggaacttg ttagggcaac aacatggaag nnnnnnnnnn acagcagaca cctagttggc gaataactaa nnatttatta gagggaagag agctttgaga actaaaaatc ttggataaaa gaagttcttc atcactttgc ccatcagata attacagaag aattctgaat taaggttaat&lt; 221〉 misc_feature &lt; 222〉 (126) .. (142) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 380 atattatact aattccatta gaaatnnnnn agggaacttg ttagggcaac aggatgagatt agat agat agatag cctag gaagttcttc atcactttgc ccatcagata attacagaag aattctgaat taaggttaat

&lt;210&gt; 381 &lt;211&gt; 481 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 40199—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （110)·.(235) &lt;223&gt; n 為 a，g，c 或 t 98677.doc 310-&lt; 210 &gt; 381 &lt; 211 &gt; 481 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 40199—at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222〉 (110) .. (235) &lt; 223 &gt; n is a, g, c or t 98677.doc 310-

200533758 &lt;220&gt; &lt;221&gt; misc^feature &lt;222〉 （318)·.(324) &lt;223&gt; η 為 a，g，c 或 t &lt;400&gt; 381 gtttcacctc tttgctccct gagttcactc tccgaagtct gatccctgcc aaaaagtggc tggaagagtc ccttagtact cttctagcat ttagatctac actctcgagn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnaagaa aagcgcagag aaatcggtgt ctgacgattt tggaaatgag aacaatctca aaaaaaaaaa aaaaaaaaaa aaaaaaannn nnnngaaaag agaaaaaaaa gactagccag ccaggaagat gaatcctagc ttcttccatt ggaaaattta agacaagttc aacaacaaaa catttgctct ggggggcagg gaaaacacag atgtgttgca aaggtaggtt gaagggacct ctctcttacc a 60 120 180 240 300 360 420 480 481200533758 &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222> (318) · (324) &lt; 223 &gt; η is a, g, c or t &400; 381 gtttcacctc tttgctccct gagttcactc tccgaagtct gatccctccc ggtaa aaa cttctagcat ttagatctac actctcgagn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnaagaa aagcgcagag aaatcggtgt ctgacgattt tggaaatgag aacaatctca aaaaaaaaaa aaaaaaaaaa aaaaaaannn nnnngaaaag agaaaaaaaa gactagccag ccaggaagat gaatcctagc ttcttccatt ggaaaattta agacaagttc aacaacaaaa catttgctct ggggggcagg gaaaacacag atgtgttgca aaggtaggtt gaagggacct ctctcttacc a 60 120 180 240 300 360 420 480 481

&lt;210&gt; 382 &lt;211〉 418 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 4021 〇t HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 （220)..(253) 98677.doc •311 - 200533758 &lt;223〉η 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （45)..(45) &lt;223〉n 為 a，g，c 或 t &lt;400〉 382&lt; 210 &gt; 382 &lt; 211〉 418 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 4021 〇t HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222> (220 ) .. (253) 98677.doc • 311-200533758 &lt; 223> η is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (45) .. (45) &lt; 223 〉 N is a, g, c or t &lt; 400〉 382

60 120 180 240 300 360 418 gctacgtaag gcagcccgtg aaccaagcct actttttctg tcatntgatt caccatgtca gtaagcgtat ctggaattac tcttattcca ctatcacaaa tccatataag atcatacttt gcaacttcat atcctggcat taaattatta attttaggat taatgccaac ttttttgcca cctataaaca atctagcatc aacatttgga tattttccan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnteatgate ttgtacacaa aggagcactt catatttggg ataatccaat tcaaagaatg tttccaggtt gttgattaag ttaggateta cccctttcag tggtttcaga agagagacac ctgggagctt getataagge tgtttgtcag ttgeettett gttgaggt &lt;210〉 383 &lt;211&gt; 539 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 40215—at HG-U95Av2 &lt;220&gt; &lt;221〉 misc_feature &lt;222〉 （422)..(445) &lt;223&gt; n 為 a，g，c 或 t 98677.doc -312- 200533758 &lt;400〉 38360 120 180 240 300 360 418 gctacgtaag gcagcccgtg aaccaagcct actttttctg tcatntgatt caccatgtca gtaagcgtat ctggaattac tcttattcca ctatcacaaa tccatataag atcatacttt gcaacttcat atcctggcat taaattatta attttaggat taatgccaac ttttttgcca cctataaaca atctagcatc aacatttgga tattttccan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnteatgate ttgtacacaa aggagcactt catatttggg ataatccaat tcaaagaatg tttccaggtt gttgattaag ttaggateta cccctttcag tggtttcaga agagagacac ctgggagctt getataagge tgtttgtcag ttgeettett gttgaggt &lt; 210〉 383 &lt; 211 &gt; 539 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 40215-at HG-U95Av2 &lt; 220 &gt; &lt; 221〉 misc_feature &lt; 222> (422) .. (445) &lt; 223 &gt; n is a, g, c or t 98677.doc -312- 200533758 &lt; 400> 383

caatgtccac tcaagttgca atgcaaaact ctggctcata ttcaatttct cagtttcaat ccagaatgat caggtggacc aaactacgaa ttaacatgct tcctgctaca ataatttgtg agccaatttc agaatgcttt gttgccagtt taattattgg atgggcagcc caccatgtgt tcagatggga tattatggta tttttcatgt gtcattgcct ggcatggttt atatttgact acattcaact caggggtgtc cagggtggca cactgtgttt ttcaaaactt gattatgcag tcgcctggtt catccgcgaa tccatgacaa tatacatttt tttgtctgca ttatgggacc caactataag ctggagaact ggtcgctaca gattacgctg tgggggtaca gcagaggaaa tnnnnnnnnn nnnnnnnnnn nnnnntgact gtatataaag gaaaaaagag aagtattata aattatgttt atataaatgc ttttaaaaat ctaccttctg tagttttatc acatgtatg &lt;210&gt; 384 &lt;211&gt; 177 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40236_at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 （54)..(55) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 384 ctttcctcgt gttgggcctg agtgtcttga ccacttacgg agttcatgcc atcnncaggc 98677.doc -313- 120 200533758 177 tggaggcctg gagcctcgct ctcctcgcgc tgtttcttgt tctcttcgtt gccatcgttc tcaccatctg gaggcagccc cagaatcaac gaaaagtagc cttcatggtt ccattct &lt;210〉 385 &lt;211&gt; 484 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40240—at HG-U95Av2caatgtccac tcaagttgca atgcaaaact ctggctcata ttcaatttct cagtttcaat ccagaatgat caggtggacc gtatataaag gaaaaaagag aagtattata aaactacgaa ttaacatgct tcctgctaca ataatttgtg agccaatttc agaatgcttt gttgccagtt taattattgg atgggcagcc caccatgtgt tcagatggga tattatggta tttttcatgt gtcattgcct ggcatggttt atatttgact acattcaact caggggtgtc cagggtggca cactgtgttt ttcaaaactt gattatgcag tcgcctggtt catccgcgaa tccatgacaa tatacatttt tttgtctgca ttatgggacc caactataag ctggagaact ggtcgctaca gattacgctg tgggggtaca gcagaggaaa tnnnnnnnnn nnnnnnnnnn nnnnntgact aattatgttt atataaatgc ttttaaaaat ctaccttctg tagttttatc acatgtatg &lt; 210 &gt; 384 &lt; 211 &gt; 177 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 40236_at HG-U95Av2 &lt; 220〉 &lt; 221> misc_feature &lt; (54) .. (55) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 384 ctttcctcgt gttgggcctg agtgtcttga ccacttacgg agttcatgcc atcnncagggagcacccctcgctctgctctctcgtctgctctgctctgctctcgtctgctct cc cagaatcaac gaaaagtagc cttcatggtt ccattct &lt; 210〉 385 &lt; 211 &gt; 484 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 40240-at HG-U95Av2

&lt;220&gt; &lt;221〉 misc_feature &lt;222〉 （233)..(284) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221〉 misc_feature &lt;222〉 （299)..(313) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （315)..(315) &lt;223〉n 為 a, g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （317)..(317) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 385 986^7.000 -314- 60 60&lt; 220 &gt; &lt; 221〉 misc_feature &lt; 222〉 (233) .. (284) &lt; 223〉 n is a, g, c or t &lt; 220 &gt; &lt; 221〉 misc_feature &lt; 222〉 (299) .. (313) &lt; 223> n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (315) .. (315) &lt; 223> n is a, g, c Or t &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (317) .. (317) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 385 986 ^ 7.000 -314- 60 60

200533758 tctcgctgcc tcacaagcag tgacacctcg ggtcctttcc gttgctatgg tgaaaattcc tggatggaat ggatcacatg agggtttctt gttgcttttg gagggtgtgg gggatatttt gttttggttt ttctgcaggt tccatgaaaa cagccctttt ccaagcccat tgtttctgtc atggtttcca tctgtcctga gcaagtcatt cctttgttat ttagcatttc gannnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnacctct agcatcgann nnnnnnnnnn nnntnanctg acggcatgga atgtataaat gagggtgggt ccttctgcag atactctaat cactacattg ctttttctat aaaactaccc ataagccttt aacctttaaa gaaaaatgaa aaaggttagt gtttgggggc cgggggagga ctgaccgctt cataagccag tacg &lt;210〉 386 &lt;211&gt; 191 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 40290—f_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 43, 46·.51， 53..57, 73， 112， 119， 120， 122 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 386 agacaggaca gtttcccagg aagatgggca gagacttgag tgngcnnnnn ncnnnnncac agagacgtgc cangcggtgt tggcgctcgg ggcgagatgc tgcccttctt tngcacgann 120 180 240 300 360 420 480 484 60 98677.doc -315- 120 180 200533758 191 cntggcctct tgcttggcgt gataaccctg tcatcttccc aaagctcatt tatgagccac cagaggctcc t &lt;210&gt; 387 &lt;211&gt; 434 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 40310_at HG-U95Av2200533758 tctcgctgcc tcacaagcag tgacacctcg ggtcctttcc gttgctatgg tgaaaattcc tggatggaat ggatcacatg agggtttctt gttgcttttg gagggtgtgg gggatatttt gttttggttt ttctgcaggt tccatgaaaa cagccctttt ccaagcccat tgtttctgtc atggtttcca tctgtcctga gcaagtcatt cctttgttat ttagcatttc gannnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnacctct agcatcgann nnnnnnnnnn nnntnanctg acggcatgga atgtataaat gagggtgggt ccttctgcag atactctaat cactacattg ctttttctat aaaactaccc ataagccttt aacctttaaa gaaaaatgaa aaaggttagt gtttgggggc cgggggagga ctgaccgctt cataagccag tacg &lt; 210> 386 &lt; 211 &gt; 191 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223〉 Probe 40290-f_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 43, 46 · .51, 53..57, 73, 112, 119, 120, 122 &lt; 223 &gt; n is a, g, c or t &lt; 400> 386 agacaggaca gtttcccagg aagatgggca gagacttgag tgngcnnnnn ncnnnnncnc agagacgtgc cangcggtgt tc tgcgg tctcgg 180 240 300 360 420 480 484 60 98677.doc -315- 120 180 200533758 191 cntggcctct tgcttggcgt gataaccctg tcatcttccc aaagctcatt tatgagccac cagaggctcc t &lt; 210 &gt; 387 &lt; 211 &gt; 434 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; HG-UU_31095_ Probe 40310

&lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （26)..(113) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （236)..(260) &lt;223&gt; n 為 a，g，c 或&lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (26) .. (113) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (236) .. (260) &lt; 223 &gt; n is a, g, c or

&lt;400〉 387 tttccgtctt nnnnnnnnnn acctggagtg cgataaagtc nnnnnnnnnn catttgagga tttgatgaga nnnnnnnnnn geccatggac ctaggttccc nnnnnnnnnn cttgcttact acaatnnnnn nnnnnnnnnn gaggctcagc atatttaaga attcagacat aaaactacaa nnnnnnnnnn nnnnnnnnnn gggaaggatt ccagtctttg aattatataa aacttcaaat nnnnnnnnnn nnnnnnnnnn ttgggtaaat tctagttggg aaactacgtg tttgtctggg nnnnnnnnnn nnnaagacct ctgagagctg atcttnnnnn gatgtaccgt gtgctgtttt 60 120 180 240 300 360 98(577.doc -316- 200533758 ataaacatat gccagattta aaaattggtt tttggttttt cttttttcta tgagataacc atgatcataa gtct &lt;210〉 388 &lt;211〉 504 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 4031〇t HG-U95Av2&Lt; 400> 387 tttccgtctt nnnnnnnnnn acctggagtg cgataaagtc nnnnnnnnnn catttgagga tttgatgaga nnnnnnnnnn geccatggac ctaggttccc nnnnnnnnnn cttgcttact acaatnnnnn nnnnnnnnnn gaggctcagc atatttaaga attcagacat aaaactacaa nnnnnnnnnn nnnnnnnnnn gggaaggatt ccagtctttg aattatataa aacttcaaat nnnnnnnnnn nnnnnnnnnn ttgggtaaat tctagttggg aaactacgtg tttgtctggg nnnnnnnnnn nnnaagacct ctgagagctg atcttnnnnn gatgtaccgt gtgctgtttt 60 120 180 240 300 360 98 (577 .doc -316- 200533758 ataaacatat gccagattta aaaattggtt tttggttttt cttttttcta tgagataacc atgatcataa gtct &lt; 210〉 388 &lt; 211> 504 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 4031〇tHG

&lt;221&gt; misc—feature &lt;222&gt; (42)..(79) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc—feature &lt;222〉 （81)..(82) &lt;223〉n 為 a，g，c 或 t • &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （272)..(299) &lt;223〉n 為 a, g，c 或 t &lt;220〉 &lt;221〉 misc一feature &lt;222〉 （219)..(219) &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 388 98677.doc 3Π- 60 60&lt; 221 &gt; misc-feature &lt; 222 &gt; (42) .. (79) &lt; 223〉 n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> (81) .. (82) &lt; 223〉 n is a, g, c or t • &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (272) .. (299) &lt; 223> n is a, g, c or t &lt; 220〉 &lt; 221〉 misc-feature &lt; 222〉 (219) .. (219) &lt; 223〉 n is a, g, c or t &lt; 400 &gt; 388 98677.doc 3Π- 60 60

200533758 ctgtgggcca agacaccagc cctgtcctag cccttcagta annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng nnaagacaag cccctcagca ggagagaggc ccagaggctc cagctggcca ccgtgcccca caagatggcc cctgtgtggt tccctttacc ttggcttcct ggcccagtcc ctgcctctcc acctgcaccc tgcttcctng gcccagtccc aggttggagt ccctctgcat agctgactac tcatgcattg cnnnnnnnnn nnnnnnnnnn nnnnnnnnnc aacaccaaac gtggttgcca catttcatca gacagacacc tccctctgga gatgcagttg agtgacaacc ttgttacatt gtagcctaga ccaattctgt gtggatattt aagtgaacat gtttacaatt tttgtatata tcactctctc cctctcctga aagaccagag attgtgtatt ttcagtgtcc catgttccga ctgc &lt;210〉 389 &lt;211&gt; 172 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 40322—at HG-U95Av2 &lt;400&gt; 389 ttgctgtctg atctttgtag actgttcctg tttgctggga gcttctctgc tgcttaaatt gttcgtcctc ccccactccc tcctatcgtt ggtttgtcta gaacactcag ctgcttcttt ggtcatcctt gttttctaac tttatgaact ccctctgtgt cactgtatgt ga200533758 ctgtgggcca agacaccagc cctgtcctag cccttcagta annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng nnaagacaag cccctcagca ggagagaggc ccagaggctc cagctggcca ccgtgcccca caagatggcc cctgtgtggt tccctttacc ttggcttcct ggcccagtcc ctgcctctcc acctgcaccc tgcttcctng gcccagtccc aggttggagt ccctctgcat agctgactac tcatgcattg cnnnnnnnnn nnnnnnnnnn nnnnnnnnnc aacaccaaac gtggttgcca catttcatca gacagacacc tccctctgga gatgcagttg agtgacaacc ttgttacatt gtagcctaga ccaattctgt gtggatattt aagtgaacat gtttacaatt tttgtatata tcactctctc cctctcctga aagaccagag attgtgtatt ttcagtgtcc catgttccga ctgc &lt; 210> 389 &lt; 211 &gt; 172 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 40322-at HG-U95Av2 &lt; 400 &gt; 389 ttgctgtctt atctttgtag actgttcctctc tctctctgtttct tcctatcgtt ggtttgtcta gaacactcag ctgcttcttt ggtcatcctt gttttctaac tttatgaact ccctctgtgt cactgtatgt ga

&lt;210〉 390 &lt;211〉 547 &lt;212&gt; DNA 120 180 240 300 360 420 480 504 60 120 98677.doc • 318- 172&lt; 210〉 390 &lt; 211〉 547 &lt; 212 &gt; DNA 120 180 240 300 360 420 480 504 60 120 98677.doc • 318- 172

200533758 &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 40333_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 32, 36, 48, 67·.90, 93, 99， 101， 241..260, 479, 497 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 390 agcatcactc acagcgggcc aggaagaaga anaagnactg ccggcgcnac tcgctctatg tggactnnnn nnnnnnnnnn nnnnnnnnnn ctnggattnt nggccccacc aggctaccag gccttctact gccatgggga ctgccccttt ccactggctg accacctcaa ctcaaccaac catgccattg tgcagaccct ggtcaattct gtcaattcca gtatccccaa agcctgttgt nnnnnnnnnn nnnnnnnnnn catctccatg ctgtacctgg atgagtatga taaggtggta ctgaaaaatt atcaggagat ggtagtagag ggatgtgggt gccgctgaga tcaggcagtc cttgaggata gacagatata cacaccacac acacacacca catacaccac acacacacgt tcccatccac tcacccacac actacacaga ctgcttcctt atagctggac ttttatttna aaaaaaaaaa aaaaaangga aaaaatccct aaacattcac cttgacctta tttatgactt tacgtgc &lt;210〉 391 &lt;211〉 508 &lt;212&gt; DNA &lt;213&gt;人類 60 120 180 240 300 360 420 480 540 547 98677.doc -319- 60 60200533758 &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223〉 Probe 40333_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 32, 36, 48, 67 · .90, 93, 99, 101, 241 ..260, 479, 497 &lt; 223 &gt; n is a, g, c or t &lt; 400> 390 agcatcactc acagcgggcc aggaagaaga anaagnactg ccggcgcnac tcgctctatg tggactnnnn nnnnnnnnnn nnnnnnnnnn ctnggattnt nggccccacc aggctaccag gccttctact gccatgggga ctgccccttt ccactggctg accacctcaa ctcaaccaac catgccattg tgcagaccct ggtcaattct gtcaattcca gtatccccaa agcctgttgt nnnnnnnnnn nnnnnnnnnn catctccatg ctgtacctgg atgagtatga taaggtggta ctgaaaaatt atcaggagat ggtagtagag ggatgtgggt gccgctgaga tcaggcagtc cttgaggata gacagatata cacaccacac acacacacca catacaccac acacacacgt tcccatccac tcacccacac actacacaga ctgcttcctt atagctggac ttttatttna aaaaaaaaaa aaaaaangga aaaaatccct aaacattcac cttgacctta tttatgactt tacgtgc &lt; 210> 391 &lt; 211> 508 &lt; 212 &gt; DNA &lt; 213 &gt; human 60 120 180 240 300 360 420 480 540 547 98677.doc -319- 60 60

200533758 &lt;220&gt; &lt;223〉 Probe 40362—at HG-U95Av2 &lt;400〉 391 tgtcacttgg tgatacagct ctgcagaacc tggagcagct gctagacggg ccagaagccc agggcagctg ggcagagctg gcagagcgtc tggggctgcg cagcctggta gacacgtacc gacagacaac ctcacccagt ggcagcctcc tgcgcagcta cgagctggct ggcggggacc tggcaggtct actggaggcc ctgtctgaca tgggcctaga ggagggagtg aggctgctga ggggtccaga aacccgagac aagctgccca gcacagaggt gaaggaagac agtgcgtacg ggagccagtc agtggagcag gaggcagaga agctgggccc accccctgag ccaccaggag ggctctcgca cgggcacccc cagcctcagg tgactgacct gctgcctgcc cccagccccc ttcccggacc ccctgtacag cgtccccacc tatttcaaat cttatttaac accccacacc cacccctcag ttgggacaaa taaaggat &lt;210&gt; 392 &lt;211〉 494 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 40367^at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 156, 160, 162, 163, 383..405 &lt;223&gt; n 為 a, g，c 或 t &lt;400&gt; 392 120 180 240 300 360 420 480 508 98677.doc -320- 60 60200533758 &lt; 220 &gt; &lt; 223> Probe 40362-at HG-U95Av2 &lt; 400> 391 tgtcacttgg tgatacagct ctgcagaacc tggagcagct gctagacggg ccagaagccc agggcagctg ggcagagctg gcagagcgtc tggggctgcg cagcctggta gacacgtacc gacagacaac ctcacccagt ggcagcctcc tgcgcagcta cgagctggct ggcggggacc tggcaggtct actggaggcc ctgtctgaca tgggcctaga ggagggagtg aggctgctga ggggtccaga aacccgagac aagctgccca gcacagaggt gaaggaagac agtgcgtacg ggagccagtc agtggagcag gaggcagaga agctgggccc accccctgag ccaccaggag ggctctcgca cgggcacccc cagcctcagg tgactgacct gctgcctgcc cccagccccc ttcccggacc ccctgtacag cgtccccacc tatttcaaat cttatttaac accccacacc cacccctcag ttgggacaaa taaaggat &lt; 210 &gt; 392 &lt; 211> 494 &lt; 212> DNA &lt; 213> human &lt; 220> &lt; 223 &gt; Probe 40367 ^ at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 156, 160, 162, 163, 383..405 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 392 120 180 240 300 360 420 480 508 98677.doc -320- 60 60

200533758 gtgtctccaa gagacatgtt aggataagca ggtctttgca ccaagatgaa cacagctggt cacagataag gccattgcta gtaacttttg gccatgatgg aaaagggcat cctctccaca aaagagaaaa acgtcaagcc aaacacaaac agcggnaacn gnnttaagtc cagctgtaag agacaccctt tgtacgtgga cttcagtgac gtggggtgga atgactggat tgtggctccc ccggggtatc acgcctttta ctgccacgga gaatgccctt ttcctctggc tgatcatctg aactccacta atcatgccat tgttcagacg ttggtcaact ctgttaactc taagattcct aaggcatgct gtgtcccgac agnnnnnnnn nnnnnnnnnn nnnnntacct tgacgagaat gaaaaggttg tattaaagaa ctatcaggac atggttgtgg agggttgtgg gtgtcgctag tacagcaaaa ttaa &lt;210〉 393 &lt;211〉 533 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40370—f_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; (322)..(366) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （291)..(291) &lt;223〉n 為 a，g，c 或 t 120 180 240 300 360 420 480 494 98677.doc -321 - 60 60200533758 gtgtctccaa gagacatgtt aggataagca ggtctttgca ccaagatgaa cacagctggt cacagataag gccattgcta gtaacttttg gccatgatgg aaaagggcat cctctccaca aaagagaaaa acgtcaagcc aaacacaaac agcggnaacn gnnttaagtc cagctgtaag agacaccctt tgtacgtgga cttcagtgac gtggggtgga atgactggat tgtggctccc ccggggtatc acgcctttta ctgccacgga gaatgccctt ttcctctggc tgatcatctg aactccacta atcatgccat tgttcagacg ttggtcaact ctgttaactc taagattcct aaggcatgct gtgtcccgac agnnnnnnnn nnnnnnnnnn nnnnntacct tgacgagaat gaaaaggttg tattaaagaa ctatcaggac atggttgtgg agggttgtgg gtgtcgctag tacagcaaaa ttaa &lt; 210〉 393 &lt; 211〉 533 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 40370-f_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; ( 322): (366) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222〉 (291) .. (291) &lt; 223> n is a , G, c or t 120 180 240 300 360 420 480 494 98677.doc -321-60 60

200533758 &lt;400〉 393 atcatactga cctggcagcg ggatggggag gaccagaccc aggacgtgga gctcgtggag accaggcctg caggggatgg aaccttccag aagtgggcag ctgtggtggt gccttctgga gaggagcaga gatacacgtg ccatgtgcag catgaggggc tgccggagcc cctcatgctg agatggaagc agtcttccct gcccaccatc cccatcatgg gtatcgttgc tggcctggtt gtccttgcag ctgtagtcac tggagctgcg gtcgctgctg tgctgtggag naagaagagc tcagattgaa aaggagggag cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngtgg caagtccctt tgtgacttca agaaccctga cttctctttc tgcagagacc agcccacccc tgtgcccacc atgaccctct tcctcatgct gaactgcatt ccttccccaa tcacctttcc tgttccagaa aaggggctgg gatgtctccg tctctgtctc aaa &lt;210&gt; 394 &lt;211&gt; 538 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40385_at HG-U95Av2 &lt;400〉 394 aggctgtgac atcaatgcta tcatctttca cacaaagaaa aagttgtctg tgtgcgcaaa tccaaaacag acttgggtga aatatattgt gcgtctcctc agtaaaaaag tcaagaacat gtaaaaactg tggcttttct ggaatggaat tggacatagc ccaagaacag aaagaacctt gctggggttg gaggtttcac ttgcacatca tggagggttt agtgcttatc taatttgtgc 120 180 240 300 360 420 480 533 60 120 180 9S67^.doc -322 - 240 200533758 ctcactggac ttgtccaatt aagcatcaca ttaaagttaa ttagctattt aatactaatt tatttggggg ggaataagat aaaactattt aacattcttt aatgaagttg attcatattg catcatagtt tgctttgttt actgtatttt atgttattta tagctgtagg ttttctgtgt ttccataagc tattttggtt tagtgcaaag tataaaatta tatatggact ttcttgcaag caacaagcta ttttttaaaa tgtttatatt gttttgtctc ctaaattgtt gtaattgc200533758 &lt; 400> 393 atcatactga cctggcagcg ggatggggag gaccagaccc aggacgtgga gctcgtggag accaggcctg caggggatgg aaccttccag aagtgggcag ctgtggtggt gccttctgga gaggagcaga gatacacgtg ccatgtgcag catgaggggc tgccggagcc cctcatgctg agatggaagc agtcttccct gcccaccatc cccatcatgg gtatcgttgc tggcctggtt gtccttgcag ctgtagtcac tggagctgcg gtcgctgctg tgctgtggag naagaagagc tcagattgaa aaggagggag cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngtgg caagtccctt tgtgacttca agaaccctga cttctctttc tgcagagacc agcccacccc tgtgcccacc atgaccctct tcctcatgct gaactgcatt ccttccccaa tcacctttcc tgttccagaa aaggggctgg gatgtctccg tctctgtctc aaa &lt; 210 &gt; 394 &lt; 211 &gt; 538 &lt; 212> atg + 2 &lt; 220 &lt; 220> &lt; 220 &gt; Autg tcatctttca cacaaagaaa aagttgtctg tgtgcgcaaa tccaaaacag acttgggtga aatatattgt gcgtctcctc agtaaaaaag tcaagaacat gtaaaaactg tggcttttttct ggaatggaat tggacatc ccaagaacag aaagaacctt gctgggtttggtgttg gtgc 120 180 240 300 360 420 480 533 60 120 180 9S67 ^ .doc -322 - 240 200533758 ctcactggac ttgtccaatt aagcatcaca ttaaagttaa ttagctattt aatactaatt tatttggggg ggaataagat aaaactattt aacattcttt aatgaagttg attcatattg catcatagtt tgctttgttt actgtatttt atgttattta tagctgtagg ttttctgtgt ttccataagc tattttggtt tagtgcaaag tataaaatta tatatggact ttcttgcaag caacaagcta ttttttaaaa tgtttatatt gttttgtctc ctaaattgtt gtaattgc

&lt;210〉 395 &lt;211&gt; 402 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223&gt; Probe 40391—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 117..133, 156, 158..166, 168..173, 195, 198, 199, 201..262 &lt;223&gt; n 為 a, g，c 或 t • &lt;400&gt; 395 tactttgttt acctcggtgc ttacaacaga atgctgccct acatcgtcat gggtagtctg actgtcctga ttggaatcct cacccttttt ttccctgaaa gtttgggaat gactctnnnn nnnnnnnnnn nnnagatgca gaaagtgaaa tggttnannn nnnnnnannn nnnaaaaaaa caagagactc aatgnagnna nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgaaaaac agaaaaataa gaccctgtgg agaaattcgt tgttcccact gaaatggact gactgtaacg attgacacca aaatgaacct tgctatcaag 98677.doc -323 - 200533758 402 aaatgctcgt catacagtaa actctggatg attcttccag at &lt;210〉 396 &lt;211&gt; 234 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 40393_at HG-U95Av2&lt; 210> 395 &lt; 211 &gt; 402 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 40391-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 117. .133, 156, 158..166, 168..173, 195, 198, 199, 201..262 &lt; 223 &gt; n is a, g, c or t • &lt; 400 &gt; 395 tactttgttt acctcggtgc ttacaacaga atgctgccct acatcgtcat gggtagtctg actgtcctga ttggaatcct ttccctgaaa gtttgggaat gactctnnnn nnnnnnnnnn nnnagatgca gaaagtgaaa tggttnannn nnnnnnannn nnnaaaaaaa caagagactc aatgnagnna nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgaaaaac agaaaaataa gaccctgtgg agaaattcgt tgttcccact gaaatggact gactgtaacg attgacacca aaatgaacct tgctatcaag 98677.doc -323 cacccttttt - 200533758 402 aaatgctcgt catacagtaa actctggatg attcttccag at &lt; 210> 396 &lt; 211 &gt; 234 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 40393_at HG-U95Av2

&lt;400&gt; 396 gtgtggatac tagctggaca agacagaccc gettgtattt ctgagaagga gcccatgctg tttccccacc aactgaataa ctacttggta actggggaca ttccttacct atgagtagac tcaaatactt tacacttgca cctcttcccc attgtggacc ttgagatggc tetttgttga cattaaggea tcacaagatt tacagtcagc aageagaaga gctcatccaa attt 60 120 180 234 &lt;210〉 397 &lt;211&gt; 71 &lt;212〉 DNA &lt;213&gt;人類&Lt; 400 &gt; 396 gtgtggatac tagctggaca agacagaccc gettgtattt ctgagaagga gcccatgctg tttccccacc aactgaataa ctacttggta actggggaca ttccttacct atgagtagac tcaaatactt tacacttgca cctcttcccc attgtggacc ttgagatggc tetttgttga cattaaggea tcacaagatt tacagtcagc aageagaaga gctcatccaa attt 60 120 180 234 &lt; 210> 397 &lt; 211 &gt; 71 &lt; 212> DNA &lt; 213 &gt; Human

&lt;220〉 &lt;223〉 Probe 40398—s—at HG-U95Av2 &lt;400〉 397 atttcttcct gattgacaac agtgttagac aaggtgcaaa gcgaaactgg ttgctcaagt 60 tgatagaaaa c 71&lt; 220〉 &lt; 223〉 Probe 40398—s—at HG-U95Av2 &lt; 400> 397 atttcttcct gattgacaac agtgttagac aaggtgcaaa gcgaaactgg ttgctcaagt 60 tgatagaaaa c 71

&lt;210&gt; 398 &lt;211&gt; 176 &lt;212&gt; DNA 98677.doc 324 - 200533758 &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 40399_r—at HG-U95Av2 &lt;400&gt; 398 acaatcagta tgtgcttacc tgtgttcaag tagagaaaaa tacagtagag tctgatagga catattcttg taccacagac aaaacaaatc ttatgttgca tttactatca actgctgcta atacgttatt ataaaactta cctagctcct gaattcttcc tatcttatag cttaaa&lt; 210 &gt; 398 &lt; 211 &gt; 176 &lt; 212 &gt; DNA 98677.doc 324-200533758 &lt; 213 &gt; human &lt; 220〉 &lt; 223> Probe 40399_r-at HG-U95Av2 &lt; 400 &gt; 398 acaatcagta tgtgcttacc tgtgtcaaga tag tacagtagag tctgatagga catattcttg taccacagac aaaacaaatc ttatgttgca tttactatca actgctgcta atacgttatt ataaaactta cctagctcct gaattcttcc tatcttatag cttaaa

60 120 176 &lt;210〉 399 &lt;211&gt; 199 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40427一at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature &lt;222〉 （73)..(97) &lt;223&gt; n 為 a，g，c 或 t60 120 176 &lt; 210> 399 &lt; 211 &gt; 199 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 40427-at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc-feature &lt; 222> (73) .. (97) &lt; 223 &gt; n is a, g, c or t

&lt;220&gt; &lt;221&gt; misc—feature &lt;222〉 （121)..(121) &lt;223&gt; n 為 a，g，c 或 t &lt;4〇0&gt; 399 60 catagctgct tttggcgcga aagatgccgg gtctggttga ctcaaaccct gccccgcctg agtctcagga gannnnnnnn nnnnnnnnnn nnnnnnnttg cccggagacc aagaaggcgc 98677.doc -325 - 120 200533758 ncgatgcgtg tatcatcgag aaaggagaag aacactgtgg acatctaatt gaggcccaca 180 aggaatgcat gagagccct 199 &lt;210〉 400 &lt;211〉 455 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40434_at HG-U95Av2&lt; 220 &gt; &lt; 221 &gt; misc—feature &lt; 222> (121) .. (121) &lt; 223 &gt; n is a, g, c or t &lt; 4〇0 &gt; 399 60 catagctgct tttggcgcga aagatgccgg gtctggttga ctcaaaccct gccccgt agtctcagga gannnnnnnn nnnnnnnnnn nnnnnnnttg cccggagacc aagaaggcgc 98677.doc -325 - 120 200533758 ncgatgcgtg tatcatcgag aaaggagaag aacactgtgg acatctaatt gaggcccaca 180 aggaatgcat gagagccct 199 &lt; 210> 400 &lt; 211> 455 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 40434_at HG-U95Av2

&lt;221&gt; misc_feature &lt;222〉 99·.101， 103..114， 122， 126, 128， 132， 134， 137， 138， 140··145 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 147, 150, 152..154, 157..159, 162..207 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 400 60 120 180 240 300 360&lt; 221 &gt; misc_feature &lt; 222〉 99 · .101, 103..114, 122, 126, 128, 132, 134, 137, 138, 140 ·· 145 &lt; 223> n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 147, 150, 152..154, 157..159, 162..207 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 400 60 120 180 240 300 360

agaattgcta ctcgaaggtg ccagaatgac acaaaggaca gaattccttt cccagttgtt accctagcaa ggctagggag ggcatgaaca caaacatann nannnnnnnn nnnnctacac tntctntnaa tnanttnngn nnnnnangtn annnaannnt tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngga act tactcca acaggactga gggaccaagg aaacatgatg ggggaggcag agagggcaag agtaaaactg tagcatagct tttgtcacgg tcactagctg atccctcagg tctgctgcaa acacagcatg gaggacacag atgactcttt ggtgttggtc tttttgtctg cagtgaatgt tcaacagttt gcccaggaac tgggggatca 98677.doc - 326 - 420 200533758 455 tatatgtctt agtggacagg ggtctgaagt acact &lt;210〉 401 &lt;211&gt; 434 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40493—at HG-U95Av2agaattgcta ctcgaaggtg ccagaatgac acaaaggaca gaattccttt cccagttgtt accctagcaa ggctagggag ggcatgaaca caaacatann nannnnnnnn nnnnctacac tntctntnaa tnanttnngn nnnnnangtn annnaannnt tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngga act tactcca acaggactga gggaccaagg aaacatgatg ggggaggcag agagggcaag agtaaaactg tagcatagct tttgtcacgg tcactagctg atccctcagg tctgctgcaa acacagcatg gaggacacag atgactcttt ggtgttggtc tttttgtctg cagtgaatgt tcaacagttt gcccaggaac tgggggatca 98677.doc - 326 - 420 200533758 455 tatatgtctt agtggacagg ggtctgaagt acact &lt; 210〉 401 &lt; 211 &gt; 434 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 40493-at HG-U95Av2

&lt;220〉 &lt;221&gt; misc^feature &lt;222&gt; 39, 40, 55, 60, 72, 73, 80, 81， 94， 108, 109, 111 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 401 60 120 180 240 300 360 420 agagaccctg agttcccact cagacccact cagccaaann tctcatggaa gaccnaggan gggcagcact gnntttttgn nttttttgtt tttngttttt tttttttnng nacactgtcc aaaggttttc catcctgtcc tggaatcaga gttggaagct gaggagcttc agcctctttt atggtttaat ggccacctgt tctctcctgt gaaaggcttt gcaaagtcac attaagtttg catgacctgt tatccctggg gccctatttc atagaggctg gccctattag tgatttccaa aaacaatatg gaagtgcctt ttgatgtctt acaataagaa taacatggtc cattcacctt tatgttatag atatgtcttt gtgtaaatca tttgttttga gttttcaaag aatagcccat tgttcattct tgtg &lt;210&gt; 402 &lt;211&gt; 521 98677.doc - 327 - 434&lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 39, 40, 55, 60, 72, 73, 80, 81, 94, 108, 109, 111 &lt; 223 &gt; n is a, g, c or t &lt; 400> 401 60 120 180 240 300 360 420 agagaccctg agttcccact cagacccact cagccaaann tctcatggaa gaccnaggan gggcagcact gnntttttgn nttttttgtt tttngttttt tttttttnng nacactgtcc aaaggttttc catcctgtcc tggaatcaga gttggaagct gaggagcttc agcctctttt atggtttaat ggccacctgt tctctcctgt gaaaggcttt gcaaagtcac attaagtttg catgacctgt tatccctggg gccctatttc atagaggctg gccctattag tgatttccaa aaacaatatg gaagtgcctt ttgatgtctt acaataagaa taacatggtc cattcacctt tatgttatag atatgtcttt gtgtaaatca tttgttttga gttttcaaag aatagcccat tgttcattct tgtg &lt; 210 &gt; 402 &lt; 211 &gt; 521 98677.doc-327-434

200533758 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 40496_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （26)..(26) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 402 tacaggatcc caatgacaag accaanttct acgcagctgg cctggtgtcc tgggggcccc agtgtgggac ctatgggctc tacacacggg taaagaacta tgttgactgg ataatgaaga ctatgcagga aaatagcacc ccccgtgagg actaatccag atacatccca ccagcctctc caagggtggt gaccaatgca ttaccttctg ttccttatga tattctcatt atttcatcat gactgaaaga agacacgagc gaatgattta aatagaactt gattgttgag acgccttgct agaggtagag tttgatcata gaattgtgct ggtcatacat ttgtggtctg actccttggg gtcctttccc cggagtacct attgtagata acactatggg tggggcactc ctttcttgca ctattccaca gggatacctt aattctttgt ttcctcttta cctgttcaaa attccattta cttgatcatt ctcagtatcc actgtctatg tacaataaag g &lt;210〉 403 &lt;211&gt; 467 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; 60 120 180 240 300 360 420 480 521 9867^.d〇c - 328 - 200533758 &lt;223&gt; Probe 40505_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 26, 134, 240..337, 339..344, 359..368, 370..372, 374, 375, 377 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 378, 380, 414..440 &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 403 tccccctagg gatggagggt taggtgctaa cctgaaaatc nnnnnnnnnn gctcaggcac accctattta accntttatt tatatgtttc nnnnnnnnnn tgaggngcct caactgagtc ttccacggat aaaaccactt nnnnnnnnnn ggggacagtg agccaagcca gagtcacaat gccatcctgt nnnnnnnnnn gagcatatgg ctgatgggaa ctgaagaatc tagattgcca nnnnnnnnnn gtgggagaca tatacagatt aaacttccat gttcctgggn nnnnnnnnnn 60 120 180 240 300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnann nnnnaaaaaa aaaaaaaann200533758 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220> &lt; 223 &gt; Probe 40496_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 (26) .. (26) &lt; 223 &gt; n is a, g, c or t &lt; 400> 402 tacaggatcc caatgacaag accaanttct acgcagctgg cctggtgtcc tgggggcccc agtgtgggac ctatgggctc tacacacggg taaagaacta tgttgactgg ataatgaaga ctatgcagga aaatagcacc ccccgtgagg actaatccag atacatccca ccagcctctc caagggtggt gaccaatgca ttaccttctg ttccttatga tattctcatt atttcatcat gactgaaaga agacacgagc gaatgattta aatagaactt gattgttgag acgccttgct agaggtagag tttgatcata gaattgtgct ggtcatacat ttgtggtctg actccttggg gtcctttccc cggagtacct attgtagata acactatggg tggggcactc ctttcttgca ctattccaca gggatacctt aattctttgt ttcctcttta cctgttcaaa attccattta cttg &lt; &gt; &lt;212;403; 212 &gt; &lt;212; 403 &lt; 212 521 9867 ^ .d〇c-328-200533758 &lt; 223 &gt; Probe 40505_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; 26, 134, 240..337, 339..344, 359..368, 370..372, 374, 375, 377 &lt; 223〉 n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 378, 380, 414..440 &lt; 223 &gt; n is a, g, c or t &lt; 400> 403 tccccctagg gatggagggt taggtgctaa cctgaaaatc nnnnnnnnnn tggtggtggatcc accctattta accnnnnnnt ttnnt tgt tata ggggacagtg agccaagcca gagtcacaat gccatcctgt nnnnnnnnnn gagcatatgg ctgatgggaa ctgaagaatc tagattgcca nnnnnnnnnn gtgggagaca tatacagatt aaacttccat gnncctgggn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnan nnannannan attgagggcc tccaggactt ggcaagtctt ggtnnnnnnn 360420 467 nnnnnnnnnn nnnnnnnnnn gatgggcagg caaatctgtc cgttctc &lt;210&gt; 404 &lt;211〉 501 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 4051Lat HG-U95Av2 98677-doc -329 -nnnnnnnnan nnannannan attgagggcc tccaggactt ggcaagtctt ggtnnnnnnn 360420 467 nnnnnnnnnn nnnnnnnnnn gatgggcagg caaatctgtc cgttctc &lt; 210 &gt; 404 &lt; 211 &lt; 213> Human> &lt; 213 &gt; 213> human &lt; 212 &gt; DNA 329-

200533758 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （418)..(445) &lt;223&gt; η 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （262)..(262) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 404 ccgttcacca gttgccattg agggtttcag agagcctttt tctaggccta catgctttgt gaacaagtcc ctgtaattgt tgtttgtatg tataattcaa agcaccaaaa taagaaaaga tgtagattta tttcatcata ttatacagac cgaactgttg tataaattta tttactgcta gtcttaagaa ctgctttctt tcgtttgttt gtttcaatat tttccttctc tctcaatttt tggttgaata aactagatta cnattcagtt ggcctaaggt ggttgtgctc ggagggtttc ttgtttcttt tccattttgt ttttggatga tatttattaa atagcttcta agagtccggc ggcatctgtc ttgtccctat tcctgcagcc tgtgctgagg gtagcagtgt atgagctnnn nnnnnnnnnn nnnnnnnnnn nnnnncgaca ggccacgtcc tgcaatcggc ccggctgcct cttcgccctg tcgtgttctg t &lt;210&gt; 405 &lt;211&gt; 454 &lt;212&gt; DNA &lt;213&gt;人類 60 120 180 240 300 360 420 480 501 98677.doc -330 -200533758 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 (418) .. (445) &lt; 223 &gt; η is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (262 ) .. (262) &lt; 223 &gt; n is a, g, c or t &lt; 400> 404 ccgttcacca gttgccattg agggtttcag agagcctttt tctaggccta catgctttgt gaacaagtcc ctgtaattgt tgtttgtatg tataattcaa agcaccaaaa taagaaaaga tgtagattta tttcatcata ttatacagac cgaactgttg tataaattta tttactgcta gtcttaagaa ctgctttctt tcgtttgttt gtttcaatat tttccttctc tctcaatttt tggttgaata aactagatta cnattcagtt ggcctaaggt ggttgtgctc ggagggtttc ttgtttcttt tccattttgt ttttggatga tatttattaa atagcttcta agagtccggc ggcatctgtc ttgtccctat tcctgcagcc tgtgctgagg gtagcagtgt atgagctnnn nnnnnnnnnn nnnnnnnnnn nnnnncgaca ggccacgtcc tgcaatcggc ccggctgcct cttcgccctg tcgtgttctg t &lt; 210 &gt; 405 &lt; 211 &gt; 454 &lt; 212 &gt; DNA &lt; 213 &gt; human 60120180240300 360 420 480 501 98677.doc -330-

200533758 &lt;220〉 &lt;223&gt; Probe 40568—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 118..132, 134, 263..282, 284, 290..324, 326 &lt;223&gt; n 為 a，g, c 或 t &lt;400〉 405 cacatgatta caattgccag tagagttgtt gtttggggta caagatgaga agaaagaaaa acctacagcc tttctacatt ctgacatgct aacagtggtt taagtttcta aagtgttnnn nnnnnnnnnn nngncaaggg gagggagcag aagcacttat gtttacggat attttaaact ctgttagaga gcagcctttg aaaatcccca atttggttct gctttttgac ctctctctac cttttcaggg taatctttgt ggnnnnnnnn nnnnnnnnnn nnangctttn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngnccct gagcgatctt ctatgcagtt ctgccatgcg tcctgttggt ctctctgtgt tctttgttac ttgggtgcaa tagcaacttc cctaccccgt gcattccatc tttcatgttg tgtaaagttc ttca 60 120 180 240 300 360 420 454200533758 &lt; 220〉 &lt; 223 &gt; Probe 40568-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; 118..132, 134, 263..282, 284, 290..324, 326 &lt; 223 &gt; n is a, g, c or t &lt; 400> 405 cacatgatta caattgccag tagagttgtt gtttggggta caagatgaga agaaagaaaa acctacagcc tttctacatt ctgacatgct aacagtggtt taagtttcta aagtgttnnn nnnnnnnnnn nngncaaggg gagggagcag aagcacttat gtttacggat attttaaact ctgttagaga gcagcctttg aaaatcccca atttggttct gctttttgac ctctctctac cttttcaggg taatctttgt ggnnnnnnnn nnnnnnnnnn nnangctttn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngnccct gagcgatctt ctatgcagtt ctgccatgcg tcctgttggt ctctctgtgt tctttgttac ttgggtgcaa tagcaacttc cctaccccgt gcattccatc tttcatgttg tgtaaagttc ttca 60 120 180 240 300 360 420 454 454

&lt;210〉 406 &lt;211&gt; 417 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40604_at HG-U95Av2 &lt;220〉 &lt;221〉mi sc一feature &lt;222〉 （211)..(285) 98677.doc -331 - 60 200533758 &lt;223〉η 為 a，g，c 或 t &lt;400〉 406&lt; 210〉 406 &lt; 211 &gt; 417 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 40604_at HG-U95Av2 &lt; 220> &lt; 221〉 mi sc-feature &lt; 222〉 ( 211) .. (285) 98677.doc -331-60 200533758 &lt; 223> η is a, g, c or t &lt; 400> 406

120 180 240 300 360 417 atggtttgac ttattcttcg tatcattaga agaaccccag agatagcatt cctctatttt attttacttt cttttggatt gcactgattg tttttgtggg aatgacactt tatctggcaa agtaactgag agtttggtaa aagaatattt tcttctctga ataataatta ttttcacagt gaaaatttca gtattttatc actaatgtat nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnctgcc tgtttggaca ataggttttg ggtagtacag attaggataa gtaagcttat atatgcacag agattattgt attacctgta aattgattta caagtactta aaagcgtggt ccccagtgag gccaaga &lt;210&gt; 407 &lt;211〉 494 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; • &lt;223〉 Probe 40606一at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 128..143, 376, 377, 380, 381， 383..390, 392, 394, 445 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 407 60 tcgtctccta tgagcaacgc cagaattata aggatgactt caatgcagag tatgatgagt acagagcttt gcatgccagg atggagactg tagctagaag atttatcaaa ctagatgcac 98677.doc -332 - 120 180 200533758 aaagaaannn nnnnnnnnnn aagaatatca gaagataaag aatatcttca taacaagctg aagcagagtc atggtcctag atttatttaa aattcnnaan gaaagtttca gtattagtaa ctgcatttcg gaag nnntcaaaag agtatcagaa cagtctagtc ccaattacca gctcacatca aaaggctaat aactctgctt ggaccagaag nannnnnnnn anantctaaa acttngagtt actttttctt tgttcatgaa gaagtcttac tgaagaaaaa tacagatgtg aggtgaattt gaccaacagc atgtgaataa acttaagctt aaggtgaaac tttggctgtt ttccatttta ctttgcttcc 240 300 360 420 480 494 &lt;210〉 408 &lt;211&gt; 470 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40626_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature • &lt;222〉 26..29, 380, 425 &lt;223〉n 為 a，g，c 或 t &lt;400〉 408 ctgtgttccc cccagccctc ccaagatcac gtaatgctct tcttggaacc tagttttaca gcagtcaatg ttcatcttct tgaccnnnna aataagggag gcagagtaaa ccaacctggc tgctagaaga tgcacagccc gagcatagcc tctaagcctt acccttggaa tgagaggtta taggcctccc gtccatcctg aacatgctgg catggcctgc cactcctcta agccccatat 60 120 180 240 98677.doc -333 - 200533758 ctagcccaac ctatcagagg actgacaggc ttgcngactg ctagtccctg ccaactgctg agaaggtacn ctttaataca aaaacaagaa tcttccagtc gtgcctctgg tcacagtgac gtggccctta tccttcagcc atatccccac attgtgtgtg gaaatctctc tgtgctcctc agtgccctga tctctgccac tccagtccca tccctccctg gctgcatctc120 180 240 300 360 417 atggtttgac ttattcttcg tatcattaga agaaccccag agatagcatt cctctatttt attttacttt cttttggatt gcactgattg tttttgtggg aatgacactt tatctggcaa agtaactgag agtttggtaa aagaatattt tcttctctga ataataatta ttttcacagt gaaaatttca gtattttatc actaatgtat nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnctgcc tgtttggaca ataggttttg ggtagtacag attaggataa gtaagcttat atatgcacag agattattgt attacctgta aattgattta caagtactta aaagcgtggt ccccagtgag gccaaga &lt; 210 &gt; 407 &lt; 211〉 494 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220 &gt; • &lt; 223〉 Probe 40606-at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222〉 128. 143, 376, 377, 380, 381, 383..390, 392, 394, 445 &lt; 223 &gt; n is a, g, c or t &lt; 400> 407 60 tcgtctccta tgagcaacgc cagaattata aggatgactt caatgcagag tatgatgagt acagagctaga atgatagatagat ctagatgcac 98677.doc -332-120 180 200533758 aaagaaannn nnnnnnnnnn aagaatatca gaagataaag aatatcttca taacaagctg aagcagagtc a tggtcctag atttatttaa aattcnnaan gaaagtttca gtattagtaa ctgcatttcg gaag nnntcaaaag agtatcagaa cagtctagtc ccaattacca gctcacatca aaaggctaat aactctgctt ggaccagaag nannnnnnnn anantctaaa acttngagtt actttttctt tgttcatgaa gaagtcttac tgaagaaaaa tacagatgtg aggtgaattt gaccaacagc atgtgaataa acttaagctt aaggtgaaac tttggctgtt ttccatttta ctttgcttcc 240 300 360 420 480 494 &lt; 210> 408 &lt; 211 &gt; 470 &lt; 212 〉 DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 40626_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature • &lt; 222〉 26..29, 380, 425 &lt; 223> n is a, g, c or t &lt; 400> 408 ctgtgttccc cccagccctc ccaagatcac gtaatgctct tcttggaacc tagttttaca gcagtcaatg ttcatcttct tgaccnnnna aataagggag gcagagtaaa ccaacctggc tgctagaaga tgcacagccc gagcatagcc tctaagcctt acccttggaa tgagaggtta taggcctccc gtccatcctg aacatgctgg catggcctgc cactcctcta agccccatat 60 120 180 240 98677.doc -333 - 200533758 ctagcccaac ctatcagagg actgacaggc ttgcngactg ctagtccctg ccaactgctg agaaggtacn ctttaataca aaaacaagaa tcttccagtc gtgcctctgg tcacagtgac gtggccctta tccttcagcc atatccccac attgtgtgtg gaaatctctc tgtgctcctc agtgccctga tctctgccac tccagtccca tccctccctg gctgcatctc

&lt;210〉 409 &lt;211&gt; 605 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40648一at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 449, 450, 452, 458, 461..463, 465..468, 470 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 409 atccaattgt acctgatgtt tttggtattt gtcttcctta ccaagtgaac tccatggccc&lt; 210〉 409 &lt; 211 &gt; 605 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 40648-at HG-U95Av2 &lt; 220> &lt; 221〉 misc_feature &lt; 222〉 449, 450, 452, 458, 461..463, 465..468, 470 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 409 atccaattgt acctgatgtt tttggtattt gtcttcctta ccaagtgaac tccatggccc

caaagcacca gatgaatgtt gttaagtaag ctgtcattaa aaatacataa tatatattta tttaaagaga aaaaatatgt gtatatcatg gaaaaagaca aggatatttt aataaaacat tacttatttc atttcactta tcttgcatat cttaaaatta agcttcagct gctccttgat attaacattt gtacagagtt gaagttgttt tttcaagttc ttttcttttt catgactatt aaatgtaaaa atatttgtaa aatgaaatgc catatttgac ttggcttctg gtcttgatgt atttgataag aatgattcat tcaatgttta aagttgtata actgattaat tttctgatat 98677.doc • 334 - 200533758 ggcttcctaa cagtggtcgg gggcaattgc ggtct taaaatatga cagcggcctt tctgaccatt ataaggaann gtggcctttg cttggcattg anaaaaanaa caaaggaatt ctttatagag nnnannnnan cccttaatgc atatggaaaa acttgaaaga ctggtccttg accacaccagcaaagcacca gatgaatgtt gttaagtaag ctgtcattaa aaatacataa tatatattta tttaaagaga aaaaatatgt gtatatcatg gaaaaagaca aggatatttt aataaaacat tacttatttc atttcactta tcttgcatat cttaaaatta agcttcagct gctccttgat attaacattt gtacagagtt gaagttgttt tttcaagttc ttttcttttt catgactatt aaatgtaaaa atatttgtaa aatgaaatgc catatttgac ttggcttctg gtcttgatgt atttgataag aatgattcat tcaatgttta aagttgtata actgattaat tttctgatat 98677.doc • 334 - 200533758 ggcttcctaa cagtggtcgg gggcaattgc ggtct taaaatatga cagcggcctt tctgaccatt ataaggaann gtggcctttg cttggcattg anaaaaanaa caaaggaatt ctttatagag nnnannnnan cccttaatgc atatggaaaa acttgaaaga ctggtccttg accacaccag

&lt;210〉 410 &lt;211&gt; 275 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40670_at HG-U95Av2 &lt;220&gt; &lt;221&gt; mi sc一feature &lt;222&gt; 109..111, 115..124, 126..130, 133, 136, 140, 143..149 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 410 tgctggtgcc ttcattcatg aaaagcatgc ccatacgatt aaacctgcga gatcggagtt&lt; 210> 410 &lt; 211 &gt; 275 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 40670_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222 &gt; 109 ..111, 115..124, 126..130, 133, 136, 140, 143..149 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 410 tgctggtgcc ttcattcatg aaaagcatgc ccatacgatt aaacctgcga gatcggagtt

ctttaattag gaatggaatg caacagattt ggacaagtca aggacaagnn ntttnnnnnn nnnnannnnn ttntcnctgn tannnnnnnc agtatgtagc cgagaaccat atggagaaca tcaaatacag tggaacaaat gtaactgcta ttgatgtcac actttgtgaa gtagtctttg ttgcttaaaa agggtgacat ctagtggcta aacatctttaattag gaatggaatg caacagattt ggacaagtca aggacaagnn ntttnnnnnn nnnnannnnn ttntcnctgn tannnnnnnc agtatgtagc cgagaaccat atggagaaca tcaaatacag tggaacaaat gtaactgcta ttgatgtcac actcctgatggaggtgat agg

&lt;210&gt; 411 &lt;211&gt; 194 &lt;212&gt; DNA 98677.doc -335 - 200533758 &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 4067l_g—at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 （44)..(74) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉&lt; 210 &gt; 411 &lt; 211 &gt; 194 &lt; 212 &gt; DNA 98677.doc -335-200533758 &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 4067l_g-at HG-U95Av2 &lt; 220> &lt; 221 &gt; mi sc-feature &lt; 222〉 (44) .. (74) &lt; 223 &gt; n is a, g, c or t &lt; 220〉

&lt;221&gt; misc_feature &lt;222〉 （79)..(81) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 411 gactcaattg cagtgatcct gttcagtggg gtgcattttt acannnnnnn nnnnnnnnnn 60 nnnnnnnnnn nnnnaaaann nggacaagcg aagggttgtt atgttggctt tgatctagca 120 catgcagttg gaaatgttga actctactta catgactggg gagttgattt tgcctgctgg 180 tgttcctaca agta 194&lt; 221 &gt; misc_feature &lt; 222〉 (79) .. (81) &lt; 223 &gt; n is a, g, c or t &lt; 400> 411 gactcaattg cagtgatcct gttcagtggg gtgcattttt acannnnnnn catngt aggt agt gaaatgttga actctactta catgactggg gagttgattt tgcctgctgg 180 tgttcctaca agta 194

&lt;210〉 412 &lt;211&gt; 104 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 40672—at HG-U95Av2 &lt;400&gt; 412 cagcaccaga tttaagatgg ataacaaact gcagttaatc cctggggtct gtggattccg 60 98677.doc -336 - 200533758 104 aatttcaaat cctcccattt tgttggtctg ttccttgcat gcta &lt;210&gt; 413 &lt;211&gt; 545 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 40687—at HG-U95Av2 &lt;220&gt;&lt; 210> 412 &lt; 211 &gt; 104 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223> Probe 40672-at HG-U95Av2 &lt; 400 &gt; 412 cagcaccaga tttaagatgg ataacaaact gcagttaatc cctggggtct gtggattccg 60 -336-200533758 104 aatttcaaat cctcccattt tgttggtctg ttccttgcat gcta &lt; 210 &gt; 413 &lt; 211 &gt; 545 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223> Probe 40687-at HG-U95Av2 &lt; 220

&lt;221&gt; misc_feature &lt;222&gt; 54..147, 156, 157, 257..300, 341, 459, 461..467, 469..471 &lt;223〉n 為 a, g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 473..491 &lt;223〉n 為 a，g，c 或 t&lt; 221 &gt; misc_feature &lt; 222 &gt; 54..147, 156, 157, 257..300, 341, 459, 461..467, 469..471 &lt; 223> n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 473..491 &lt; 223〉 n is a, g, c or t

&lt;400〉 413 aaggctctgc nnnnnnnnnn nnnnnnnnnn agggtactgg ccccaacctc acaggaaaag cggatttggc tgttcaagct agagatgact nnnnnnnnnn nnnnnnnnnn gggccctctg accctannnn gcggattgag cctgtcaagg tctgaaataa gggctgggga nnnnnnnnnn nnnnnnnaca gccttttgca nnnnnnnnnn gctgctgggt ggactggtgc acaggacttg agcagatgct nnnnnnnnnn gacagnntca gctgatccag nnnnnnnnnn cagccttgat cttgttttea atcacaaana tgctggccat nnnnnnnnnn gcatggaatg aggaacccag nnnnnnnnnn ngcacagaca tcactccttc nnnnnnnann ggannnnnnn nnnnnnnnnn ctcttggcca agccaactta nnnnnnnnnn gagcttgtgc ctagttctac nannnnnnnn 60 120 180 240 300 360 420 480 98677.doc - 337 - 540 200533758 nnnnnnnnnn ngggttgggg gatagagtta ttttgcccag gcttccttta cttcttggtc ctgta &lt;210&gt; 414 &lt;211〉 450 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 40698_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （398)·.(412) &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 414 tcaaaacgct gattaaaaga agcacggtat gatgaccaaa cataaaaagt gttttataat tgttggtgtt ttaataacaa ctaatattat tactctgata gttaaactaa ctcgagattc tcagagttta tgcccctatg attggattgg tttccaaaac aaatgctatt atttctctaa agaagaagga gattggaatt caagtaaata caactgttcc actcaacatg ccgacctaac tataattgac aacatagaag aaatgaattt tcttaggcgg tataaatgca gttctgatca ctggattgga ctgaagatgg caaaaaatcg aacaggacaa tgggtagatg gagctacatt taccaaatcg tttggcatga gagggagtga aggatgtnnn nnnnnnnnnn nngatggtgc agcaacagct agatgttaca ccgaaagaaa 545agccaactta nnnnnnnnnn 400> 413 aaggctctgc nnnnnnnnnn nnnnnnnnnn agggtactgg ccccaacctc acaggaaaag cggatttggc tgttcaagct agagatgact nnnnnnnnnn nnnnnnnnnn gggccctctg accctannnn gcggattgag cctgtcaagg tctgaaataa gggctgggga nnnnnnnnnn nnnnnnnaca gccttttgca nnnnnnnnnn gctgctgggt ggactggtgc acaggacttg agcagatgct nnnnnnnnnn gacagnntca gctgatccag nnnnnnnnnn cagccttgat cttgttttea atcacaaana tgctggccat nnnnnnnnnn gcatggaatg aggaacccag nnnnnnnnnn ngcacagaca tcactccttc nnnnnnnann ggannnnnnn nnnnnnnnnn ctcttggcca; & lt gagcttgtgc ctagttctac nannnnnnnn 60 120 180 240 300 300 360 420 480 98677.doc-337-540 200533758 nnnnnnnnnn ngggttgggg gatagagtta ttttgcccag gcttccttta cttcttggtc ctgta &lt; 210 &gt; 414 &lt; 211 &lt; 211> 450> &lt; 223 &gt; Probe 40698_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (398) ·. (412) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 414 tcaaaacgct gattaaaaga agcacggtat gatgaccaaa cataaaaagt gttttataat tgttggtgtt ttaataacaa ctaatatt at tactctgata gttaaactaa ctcgagattc tcagagttta tgcccctatg attggattgg tttccaaaac aaatgctatt atttctctaa agaagaagga gattggaatt caagtaaata caactgttcc actcaacatg ccgacctaac tataattgac aacatagaag aaatgaattt tcttaggcgg tataaatgca gttctgatca ctggattgga ctgaagatgg caaaaaatcg aacaggacaa tgggtagatg gagctacatt taccaaatcg tttggcatga gagggagtga aggatgtnnn nnnnnnnnnn nngatggtgc agcaacagct agatgttaca ccgaaagaaa 545

60 120 180 240 300 360 420 98677.doc - 338 - 45060 120 180 240 300 360 420 98677.doc-338-450

200533758 &lt;210&gt; 415 &lt;211&gt; 559 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 406一at HG-U95Av2 &lt;400〉 415 acgtgcccta caagttcaag gtgcaggcca ggaccactga gggcttcggg ccagagcgcg agggcatcat caccatagag tcccaggatg gaggaccctt cccgcagctg ggcagccgtg ccgggctctt ccagcacccg ctgcaaagcg agtacagcag catcaccacc acccacacca gcgccaccga gcccttecta gtggatgggc tgaccctggg ggcccagcac ctggaggcag gcggctccct cacccggcat gtgacccagg agtttgtgag ccggacactg accaccagcg gaacccttag cacccacatg gaccaacagt tcttccaaac ttgaccgcac cctgccccac ccccgccatg tcccactagg cgtcctcccg actcctctcc cggagcctcc tcagctactc catccttgca cccctggggg cccagcccac ccgcatgcac agagcagggg ctaggtgtct cctgggaggc atgaaggggg caaggtccgt cctctgtggg cccaaaccta tttgtaacca aagagctggg agcagcaca &lt;210〉 416 &lt;211〉 188 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40823—s—at HG-U95Av2 60 120 180 240 300 360 420 480 540 559 9S677.doc - 339 -200533758 &lt; 210 &gt; 415 &lt; 211 &gt; 559 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223〉 Probe 406_at HG-U95Av2 &lt; 400> 415 acgtgcccta caagttcaag gtgcaggcca ggaccactga gggcttgggcggccggccggcc gaggaccctt cccgcagctg ggcagccgtg ccgggctctt ccagcacccg ctgcaaagcg agtacagcag catcaccacc acccacacca gcgccaccga gcccttecta gtggatgggc tgaccctggg ggcccagcac ctggaggcag gcggctccct cacccggcat gtgacccagg agtttgtgag ccggacactg accaccagcg gaacccttag cacccacatg gaccaacagt tcttccaaac ttgaccgcac cctgccccac ccccgccatg tcccactagg cgtcctcccg actcctctcc cggagcctcc tcagctactc catccttgca cccctggggg cccagcccac ccgcatgcac agagcagggg ctaggtgtct cctgggaggc atgaaggggg caaggtccgt cctctgtggg cccaaaccta tttgtaacca aagagctggg agcagcaca &lt; 210 〉 416 &lt; 211〉 188 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 40823-s-at HG-U95Av2 60 120 180 240 300 360 360 420 480 540 559 9S677.doc-339-

200533758 &lt;220&gt; &lt;221&gt; misc— feature &lt;222〉 (84). .(98) &lt;223&gt; n為 a，g，c 或 t &lt;400〉 416 gacagcactc aactcaagca caaagtacgg gccagggggg tctttctgca ccttcatcct taatatgtca cagtttgtgt gatnnnnnnn nnnnnnnncc tgatggggca actgtgagca ttaaacctga accagaagat cgagagccta actttgcaac cattggtctg caggacatca ctttagat &lt;210〉 417 &lt;211&gt; 366 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 40899_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 39, 149..155, 168, 177, 179..198, 201, 222..246 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 417 cacacggagc gggtcttgag ggcagaaacg agctccagat attgagctgc gaggcgcgct gagcaggtcc agtcacagct ttggagccnn gaggttacnt gagcatgaaa nnnnnggcgc gacctgcggc gctgccttgg atatccangc gcacccttea aagacacact getgatnann nnnnnnnnnn nnnnnnnngg ncgatgtgcg agctgatagt gnnnnnnnnn nnnnnnnnnn 98677.doc -340 - 200533758 nnnnnngctc atggacatca agtcgcggct ggagcaggag attgccacct accgcagcct gctcgaggga caggaagatc actacaacaa tttgtctgcc tccaaggtcc tctgaggcag caggct &lt;210&gt; 418 &lt;211&gt; 439 &lt;212〉 DNA &lt;213&gt;人類 鲁 &lt;220〉 &lt;223〉 Probe 408一at HG-U95Av2 &lt;400〉 418200533758 &lt; 220 &gt; &lt; 221 &gt; misc- feature &lt; 222〉 (84).. (98) &lt; 223 &gt; n is a, g, c or t &lt; 400> 416 gacagcactc aactcaagca caaagtacgg gccagggggg tctttctgca ccttcatccca gtatgtt gatnnnnnnn nnnnnnnncc tgatggggca actgtgagca ttaaacctga accagaagat cgagagccta actttgcaac cattggtctg caggacatca ctttagat &lt; 210〉 417 &lt; 211 &gt; 366 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; 220 &gt; 220 &gt; 220 221 &gt; misc-feature &lt; 222 &gt; 39, 149..155, 168, 177, 179..198, 201, 222..246 &lt; 223 &gt; n is a, g, c or t &lt; 400> 417 cacacggagc gggtcttgag ggcagaaacg agctccagat attgagctgc gaggcgcgct gagcaggtcc agtcacagct ttggagccnn gaggttacnt gagcatgaaa nnnnnggcgc gacctgcggc gctgccttgg atatccangc gcacccttea aagacacact getgatnann nnnnnnnnnn nnnnnnnngg ncgatgtgcg agctgatagt gnnnnnnnnn nnnnnnnnnn 98677.doc -340 - 200533758 nnnnnngctc atggacatca agtcgcggct ggagcaggag attgccacct accgcagcct gctcgaggga caggaagatc actacaacaa tttgtctgcc tcca aggtcc tctgaggcag caggct &lt; 210 &gt; 418 &lt; 211 &gt; 439 &lt; 212〉 DNA &lt; 213 &gt; human Lu &lt; 220〉 &lt; 223〉 Probe 408-at HG-U95Av2 &lt; 400〉 418

attaactcta cctgcacact gtcctattat attcattctt tttgaaatgt caaccccaag ttagttcaat ctggattcat atttaatttg aaggtagaat gttttcaaat gttctccagt cattatgtta atatttctga ggagcctgca acatgccagc cactgtgata gaggctggcg gatccaagca aatggccaat gagatcattg tgaaggcagg ggaatgtatg tgcacatctg ttttgtaact gtttagatga atgtcagttg ttatttattg aaatgatttc acagtgtgtg gtcaacattt ctcatgttga aactttaaga actaaaatgt tctaaatatc ccttggacat tttatgtctt tcttgtaagg catactgcct tgtttaatgg tagttttaca gtgtttctgg cttagaacaa aggggctta &lt;210〉419 &lt;211&gt; 527 &lt;212&gt; DNA &lt;213&gt;人類 98677.doc -341 - 200533758 &lt;220&gt; &lt;223〉 Probe 41048—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （104)..(104) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉attaactcta cctgcacact gtcctattat attcattctt tttgaaatgt caaccccaag ttagttcaat ctggattcat atttaatttg aaggtagaat gttttcaaat gttctccagt cattatgtta atatttctga ggagcctgca acatgccagc cactgtgata gaggctggcg gatccaagca aatggccaat gagatcattg tgaaggcagg ggaatgtatg tgcacatctg ttttgtaact gtttagatga atgtcagttg ttatttattg aaatgatttc acagtgtgtg gtcaacattt ctcatgttga aactttaaga actaaaatgt tctaaatatc ccttggacat tttatgtctt tcttgtaagg catactgcct tgtttaatgg tagttttaca gtgtttctgg cttagaacaa aggggctta &lt; 210> 419 &lt; 211 &gt; 527 &lt; 212 &gt; DNA &lt; 213 &gt; human 98677.doc -341-200533758 &lt; 220 &gt; &lt; 223> Probe 41048-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222 〉 (104) .. (104) &lt; 223 &gt; n is a, g, c or t &lt; 220>

&lt;221&gt; misc_feature &lt;222〉 （149)..(149) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （433)..(433) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 419 ggaacagtta gttctcatct agaatgaaag ttccatatat gcattggtga atatatatgt 60 atacacatac ttacatactt atatgggtat ctgtatagat aatntgtatt agagtattat 120 atagcttctt agtagggtct caagtaagnt teattttttt tatctgggct atatacagtc 180 ctcaaataaa taatgtcttg attttatttc ageaggaata attttattta ttttgcctat 240 ttataattaa agtatttttc tttagtttga aaatgtgtat taaagttaca tttttgagtt 300 acaagagtct tataactact tgaattttta gttaaaatgt ettaatgtag gttgtagtca 360 ctttagatgg aaaattacct cacatctgtt ttettcagta ttaettaaga ttgtttattt 420 agtggtagag agnttttttt ttcagcctag aggcagctat tttaccatct ggtatttatg 480 9867'doc - 342 - 200533758 gtctaatttg tatttaaaca tatgcacaca tataaaagtt gatactg 527 &lt;210&gt; 420 &lt;211〉 414 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 41140.at HG-U95Av2&lt; 221 &gt; misc_feature &lt; 222> (149) .. (149) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc ^ feature &lt; 222> (433) .. (433) &lt; 223 &gt; n is a, g, c or t &lt; 400> 419 ggaacagtta gttctcatct agaatgaaag ttccatatat gcattggtga atatatatgt 60 atacacatac ttacatactt atatgggtat ctgtatagat aatntgtatt agagtattat 120 atagcttctt agtagggtct caagtaagnt teattttttt tatctgggct atatacagtc 180 ctcaaataaa taatgtcttg attttatttc ageaggaata attttattta ttttgcctat 240 ttataattaa agtatttttc tttagtttga aaatgtgtat taaagttaca tttttgagtt 300 acaagagtct tataactact tgaattttta gttaaaatgt ettaatgtag gttgtagtca 360 ctttagatgg aaaattacct cacatctgtt ttettcagta ttaettaaga ttgtttattt 420 agtggtagag agnttttttt ttcagcctag aggcagctat tttaccatct ggtatttatg 480 9867'doc - 342 - 200533758 gtctaatttg tatttaaaca tatgcacaca tataaaagtt gatactg 527 &lt; 210 &gt; 420 &lt; 211> 414 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 41140.at HG-U95Av2

&lt;220&gt; &lt;221&gt; misc^feature &lt;222〉 （125)..(125)&lt;223&gt; n 為 a，g, c 或 t &lt;220&gt;&lt;221〉 misc_feature &lt;222〉 （316)..(363) &lt;223〉n 為 a，g，c 或 t &lt;220〉&lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222> (125) .. (125) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221〉 misc_feature &lt; 222〉 ( 316) .. (363) &lt; 223〉 n is a, g, c or t &lt; 220〉

&lt;221〉 &lt;222〉 &lt;223&gt; misc—feature (372)..(372)n 為 a，g，c 或 t &lt;400&gt; 420 agctgctaga gttctgtctg gactttccag agaccagtat tcccttttgc tgcctctaaa aggcctgtcc ctgcagacat gagagacagc aggtctcatg ggggtgacaa gctttttttt ttttncttaa agaattttea aaatcaaatt ccagaatgat 11taeggaga tatcccagga aaattaagge ttctcttaaa cactaaaaag gcatgtaatt gettgttage aaaatggata 60 120 180 98677.doc • 343 - 240 200533758 tgacacatct ctgatacttt tttcattatt ggttgggctg agcagtcaga agacctggtc gtcgtcttga ctttgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnagggaca cngagtggcc cttcatgtac atccatggtg tgctggctta aaat &lt;210〉 421 &lt;211&gt; 586 &lt;212〉 DNA &lt;213&gt;人類&lt; 221〉 &lt; 222〉 &lt; 223 &gt; misc—feature (372) .. (372) n is a, g, c or t &lt; 400 &gt; 420 agctgctaga gttctgtctg gactttccag agaccagtat tcccttttgttgat ttgca ctgctctggat ctggat agaattttea aaatcaaatt ccagaatgat 11taeggaga tatcccagga aaattaagge ttctcttaaa cactaaaaag gcatgtaatt gettgttage aaaatggata 60 120 180 98677.doc • 343 - 240 200533758 tgacacatct ctgatacttt tttcattatt ggttgggctg agcagtcaga agacctggtc gtcgtcttga ctttgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnagggaca cngagtggcc cttcatgtac atccatggtg tgctggctta aaat &lt; 210> 421 &lt; 211 &gt; 586 &lt; 212〉 DNA &lt; 213 &gt; human

&lt;220〉 &lt;223&gt; Probe 41168_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 248, 251， 266, 376, 381·.409, 533 &lt;223〉n 為 a，g，c 或 t &lt;400〉 421 gagaacccgt actctagggc caaatccatt cttcttgccc tggctcactt gtccccccca ccgccccgcg ctggagccac tgcctagttc ttcagcccta gatggtgctc gccagacctc ctctcaatgc tcatcacaca cagggctatt cctttcctcc aatgaaccaa acgcctcccg cccacctcca ggtcccagtc ctctgttccc tttgcctggt ccacccttgc cctccctggg tcgcaganga nggtcggcct cgtcanttcc ccgcagaccg ccgcgcgtcc ctcttgtgcg gttcaccaca gttgtattta agtgatcgtg tgagtcgtcg ttaaatgcct gtctccccgc ggatcatggg ctcctngagg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt aaccccgcgc cggcataggg acctaaggcc cactggaggg cgctcatcaa gtagctgctg gatgttgacg 98677.doc -344- 540 200533758 586 aaggaagcgg cggcgcagct cagggatctc cgagtcagga cggtcggcca ganccacggg gtaacgggtc taatcgtgta ggaataaagc tgtattccag tgcttc &lt;210&gt; 422 &lt;211&gt; 512 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉&lt; 220〉 &lt; 223 &gt; Probe 41168_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 248, 251, 266, 376, 381 · .409, 533 &lt; 223〉 n is a, g, c or t &lt; 400> 421 gagaacccgt actctagggc caaatccatt cttcttgccc tggctcactt gtccccccca ccgccccgcg ctggagccac tgcctagttc ttcagcccta gatggtgctc gccagacctc ctctcaatgc tcatcacaca cagggctatt cctttcctcc aatgaaccaa acgcctcccg cccacctcca ggtcccagtc ctctgttccc tttgcctggt ccacccttgc cctccctggg tcgcaganga nggtcggcct cgtcanttcc ccgcagaccg ccgcgcgtcc ctcttgtgcg gttcaccaca gttgtattta agtgatcgtg tgagtcgtcg ttaaatgcct gtctccccgc ggatcatggg ctcctngagg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt aaccccgcgc cggcataggg acctaaggcc cactggaggg cgctcatcaa gtagctgctg gatgttgacg 98677.doc -344- 540 200533758 586 aaggaagcgg cggcgcagct cagggatctc cgagtcagga cggtcggcca ganccacggg gtaacgggtc taatcgtgta ggaataaagc tgtattccag tgcttc &lt; 210 &gt; 422 &lt; 211 &gt; 512 &lt; 212> DNA &lt; 213 &gt; human &lt; 220>

&lt;223&gt; Probe 41171_at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc一feature &lt;222&gt; 107, 365, 368..371, 374..396, 438..479 &lt;223&gt; n 為 a, g，c 或 t&lt; 223 &gt; Probe 41171_at HG-U95Av2 &lt; 220> &lt; 221 &gt; mi sc-feature &lt; 222 &gt; 107, 365, 368..371, 374..396, 438..479 &lt; 223 &gt; n is a , g, c or t

&lt;400&gt; 422 tagcaatcca tccagacaac aggagactca gggagctcag tcagcagcaa gaacccggga aaaanaannn gggtgggtgt agaggggatt ggagaaggtg catttccaag tgtaatggat ggccatggtg cctggagaaa ctagaaggaa naannnnnnn cacaaagnnn caggcccttt ctggagaggg tacttctcag taccgggcct ctggacctga attgtcaacc aataaatgat nnnnnnnnnn nnnnnnnnnn ctcatccagt tgaatgccgt aacgtgggga tggtgcatga gggccttcta caaagggtga ctatatgttg nnnnnncctg nnnnnnnnnn ag caagaccaaa tgctgtngcc gcgagatgag tgctgagctt agaaaagcca tgtggaaaaa aagatgaatg nnnnnnnnnn gtggaagctt aaggcctcca gcagcctatg tatcatatca tctatgtact aaaaaaaaaa tggtgggaag nnnnnnnnna 60 120 180 240 300 360 420 480 512 98677,ck:c -345 - 200533758 &lt;210&gt; 423 &lt;211〉 377 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt;Probe41184—s—atHG-U95Av2 &lt;220〉nnnnnnnnnn gtggaagctt 422 tagcaatcca tccagacaac aggagactca gggagctcag tcagcagcaa gaacccggga aaaanaannn gggtgggtgt agaggggatt ggagaaggtg catttccaag tgtaatggat ggccatggtg cctggagaaa ctagaaggaa naannnnnnn cacaaagnnn caggcccttt ctggagaggg tacttctcag taccgggcct ctggacctga attgtcaacc aataaatgat nnnnnnnnnn nnnnnnnnnn ctcatccagt tgaatgccgt aacgtgggga tggtgcatga gggccttcta caaagggtga ctatatgttg nnnnnncctg nnnnnnnnnn ag caagaccaaa tgctgtngcc gcgagatgag tgctgagctt agaaaagcca tgtggaaaaa aagatgaatg; &lt; 400 & gt aaggcctcca gcagcctatg tatcatatca tctatgtact aaaaaaaaaa tggtgggaag nnnnnnnnna 60 120 180 240 300 360 420 480 512 98677, ck: c -345-200533758 &lt; 210 &gt; 423 &lt; 211〉 377 &lt; 212〉 DNA &lt; 213> human &lt;; 223 &gt; Probe41184—s—atHG-U95Av2 &lt; 220>

&lt;221&gt; misc_feature &lt;222〉 （41)..(67) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 423 60 120 180 240 300 360 377 ctatgggcag tatgatctgt ggctgggata agaagggtcc nnnnnnnnnn nnnnnnnnnn nnnnnnngac tcggctctca ggaaatatgt tctccacggg tagtgggaac acttatgcct acggggtcat ggacagtggc tatcggccta atcttagccc tgaagaggcc tatgaccttg gccgcagggc tattgcttat gccactcaca gagacagcta ttctggaggc gttgtcaata tgtaccacat gaaggaagat ggttgggtga aagtagaaag tacagatgtc agtgacctgc tgcaccagta ccgggaagcc aatcaataat ggtggtggtg gcagctgggc aggtctcctc tgggaggtct tggccga &lt;210&gt; 424 &lt;211〉 448 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 98677.doc -346 - 200533758 &lt;223〉 Probe 41191—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc feature &lt;222〉 129, ,141..144, 152..175, 316 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 424 ggcctctctt agctcagtta ctcaattcat acgtagtatt ttttaaaata attttatatc 60 tgtgtaccac cccatatatt tcatattact gtttcacatg tacagctttc tacttctttg 120 taagaacanc aaccaaccaa nnnnggttta annnnnnnnn nnnnnnnnnn nnnnngggtg 180 gcagatgttc tatgcagtgt ggttcaagtt tctttgaccg cacttatatg cattgctaat 240 atggaattta agataccata cacagtctct catggaccta tctctattgt agaattatga 300 cttatgtctt acttgncaaa tttttctgaa tgtgaccttt ttttgctgat ttgctgggtt 360 tgggattaac tagcattatt ttgccacctt tatattgtat ttataaaaaa aaagtactat 420 caatcaatca tactactttg gattgttg 448&lt; 221 &gt; misc_feature &lt; 222〉 (41) .. (67) &lt; 223 &gt; n is a, g, c or t &lt; 400> 423 60 120 180 240 300 360 377 ctatgggcag tatgatctgt ggctgggata agaagggtcc nnnnnnnnnnnnnnnnnnnnnnnnnn ggaaatatgt tctccacggg tagtgggaac acttatgcct acggggtcat ggacagtggc tatcggccta atcttagccc tgaagaggcc tatgaccttg gccgcagggc tattgcttat gccactcaca gagacagcta ttctggaggc gttgtcaata tgtaccacat gaaggaagat ggttgggtga aagtagaaag tacagatgtc agtgacctgc tgcaccagta ccgggaagcc aatcaataat ggtggtggtg gcagctgggc aggtctcctc tgggaggtct tggccga &lt; 210 &gt; 424 &lt; 211> 448 &lt; 212 &gt; DNA &lt; 213> human &lt; 220〉 98677.doc -346-200533758 &lt; 223〉 Probe 41191-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc feature &lt; 222〉 129,, 141..144, 152..175, 316 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 424 ggcctctctt agctcagtta ctcaattcat acgtagtatt ttttaaaata attttatatc 60 tgtgtaccac cccatatatt tcatattact gtttcacatg tacagctttc tacttctnnct agagatacac nnnnnnn nnnnnnnnnn nnnnngggtg 180 gcagatgttc tatgcagtgt ggttcaagtt tctttgaccg cacttatatg cattgctaat 240 atggaattta agataccata cacagtctct catggaccta tctctattgt agaattatga 300 cttatgtctt acttgncaaa tttttctgaa tgtgaccttt ttttgctgat ttgctgggtt 360 tgggattaac tagcattatt ttgccacctt tatattgtat ttataaaaaa aaagtactat 420 caatcaatca tactactttg gattgttg 448

&lt;210〉 425 &lt;211&gt; 281 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 41237_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （44)..(44) &lt;223〉n 為 a，g，c 或 t 98677.doc 347 - 200533758 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （183)..(183) &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （215)..(215) &lt;223&gt; η 為 a，g，c 或 t&lt; 210〉 425 &lt; 211 &gt; 281 &lt; 212〉 DNA &lt; 213〉 Human &lt; 220〉 &lt; 223 &gt; Probe 41237_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (44). . (44) &lt; 223> n is a, g, c or t 98677.doc 347-200533758 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 (183) .. (183) &lt; 223 &gt; η is a, g, c or t &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (215) .. (215) &lt; 223 &gt; η is a, g, c or t

&lt;400&gt; 425 cctgactttg tttctgcaaa ggcacctgca tgtgtctgtg ttcntgtagg cataatgtga ggaggtgggg agaccacccc acccccatgt ccaccatgac cctcttccca cgctgacctg tgctccctcc ccaatcatct ttcctgttcc agagaggtgg ggctgaggtg tctccatctc tgnctcaact tcatggtgca ctgagctgta acttnttcct tccctattaa aattagaacc tgagtataaa tttactttct caaattcttg ccatgagagg t &lt;210&gt; 426 &lt;211&gt; 192 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 41239—r—at HG-U95Av2 &lt;400&gt; 426 tttgcaaatc tcaggataaa gtttgctaag taaattagta atgtactata gatataactg tacaaaaatt gttcaaccta aaacaatctg taattgctta ttgttttatt gtatactctt 60 120 180 240 281 60 98677.doc -348 - 120 180 200533758 192 tgtcttttta agacccctaa tagccttttg taacttgatg gcttaaaaat acttaataaa tctgccattt ca &lt;210&gt; 427 &lt;211〉 240 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉&Lt; 400 &gt; 425 cctgactttg tttctgcaaa ggcacctgca tgtgtctgtg ttcntgtagg cataatgtga ggaggtgggg agaccacccc acccccatgt ccaccatgac cctcttccca cgctgacctg tgctccctcc ccaatcatct ttcctgttcc agagaggtgg ggctgaggtg tctccatctc tgnctcaact tcatggtgca ctgagctgta acttnttcct tccctattaa aattagaacc tgagtataaa tttactttct caaattcttg ccatgagagg t &lt; 210 &gt; 426 &lt; 211 &gt; 192 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223> Probe 41239-r-at HG-U95Av2 &lt; 400 &gt; 426 tttgcaaatc tcaggataaa gtttgctaag taaattagta atgtactata gatataactg tacaaaaatt gttcaaccta aaacaatctg 240at-tattttttttttttttttttttctt 60tctt ttattttttttt 120 180 200533758 192 tgtcttttta agacccctaa tagccttttg taacttgatg gcttaaaaat acttaataaa tctgccattt ca &lt; 210 &gt; 427 &lt; 211〉 240 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉

&lt;223〉 Probe 41266—at HG-U95Av2 &lt;400&gt; 427 60 120 180 240 agtctcagtt tcttgcttgg ggaacttgtg tccctaatgt gtttagattg ctagattgct aaggagctga tactttgaca gtgtttttag acctgtgtta ctaaaaaaaa gatgaatgtc ctgaaaaggg tgttgggagg gtggttcaac aaagaaacaa agatgttatg gtgtttagat ttatggttgt taaaaatgtc atctcaagtc aagtcactgg tctgtttgca tttgatacat &lt;210〉 428 &lt;211〉 493 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 41294_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 91, 116..162, 169, 215, 227..239, 242, 273..277, 281, 284 &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 98677.doc - 349 -&Lt; 223> Probe 41266-at HG-U95Av2 &lt; 400 &gt; 427 60 120 180 240 agtctcagtt tcttgcttgg ggaacttgtg tccctaatgt gtttagattg ctagattgct aaggagctga tactttgaca gtgtttttag acctgtgtta ctaaaaaaaa gatgaatgtc ctgaaaaggg tgttgggagg gtggttcaac aaagaaacaa agatgttatg gtgtttagat ttatggttgt taaaaatgtc atctcaagtc aagtcactgg tctgtttgca tttgatacat &lt; 210> 428 &lt; 211> 493 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 41294_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 91, 116..162, 169, 215 , 227..239, 242, 273..277, 281, 284 &lt; 223 &gt; n is a, g, c or t &lt; 220〉 98677.doc-349-

200533758 &lt;221&gt; misc一feature &lt;222〉 286, 289, 293, 294, 303, 314, 452, 459, 466 &lt;223〉n 為 a，g，c 或 t &lt;400〉 428 gtgaatatct ctgtgatgaa ttccactggt ggcagtagca gtggcggtgg cattgggctg accctcgggg gaaccatggg cagcaatgcc ntgagcttct ccagcagtgc gggtcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnaggagtnc ccgcgactga gccgcctccc accactccac tcctccagcc accanccaca atcacannnn nnnnnnnnnc cnttgccgag gctgaggagt gtggggagct ggnnnnnaag natncncgng ccnngcagga ggnagctgga agcngccctg cagcgggcca agcaggatat ggcacggcag ctgcgtgagt accaggaact catgagcgtg aagctggccc tggacatcga gatcgccacc taccgcaagc tgctggaggg cgaggagagc cggttggctg gnagatggna gtgggnagcc gtgaatatct ctgtgatgaa ttc 60 120 180 240 300 360 420 480 493 &lt;210〉 429 &lt;211&gt; 446 &lt;212&gt; DNA &lt;213〉 人類 &lt;220〉 &lt;223&gt; Probe 41352_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc—feature &lt;222〉 (304)..(304) &lt;223〉 n 為 a，g，c 或 t 98677.doc 350 - 60 200533758 &lt;400〉 429200533758 &lt; 221 &gt; misc-feature &lt; 222〉 286, 289, 293, 294, 303, 314, 452, 459, 466 &lt; 223〉 n is a, g, c or t &lt; 400〉 428 gtgaatatct ctgtgatgaa ttccactggt ggcagtagca gtggcggtgg cattgggctg accctcgggg gaaccatggg cagcaatgcc ntgagcttct ccagcagtgc gggtcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnaggagtnc ccgcgactga gccgcctccc accactccac tcctccagcc accanccaca atcacannnn nnnnnnnnnc cnttgccgag gctgaggagt gtggggagct ggnnnnnaag natncncgng ccnngcagga ggnagctgga agcngccctg cagcgggcca agcaggatat ggcacggcag ctgcgtgagt accaggaact catgagcgtg aagctggccc tggacatcga gatcgccacc taccgcaagc tgctggaggg cgaggagagc cggttggctg gnagatggna gtgggnagcc gtgaatatct ctgtgatgaa ttc 60 120 180 240 300 360 420 480 493 &lt; 210> 429 &lt; 211 &gt; 446 &lt; 212 &gt; DNA &lt; 213> human &lt; 220〉 &lt; 223 &gt; Probe 41352_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 (304) .. (304) &lt; 223〉 n is a, g, c or t 98677.doc 350-60 200533758 &lt; 400〉 429

120 180 240 300 360 420 446 gttctgattt gacacactga ttttaatctt cgaatcatga cactgagtgc agaggaggtg gcattccgac agcaggacat acatgttggt gtgaagactg ggacgacact gggtagaatc tagtttttaa ttattattaa tataaaggat caaattaatt taaatatgat tctgaagtct acagaacttt tagttctgtg ctgtctatgt ggacactttg gtaaaatgca aattatgata tggacgttat cattggtctg gtgagatgtt tcatatttgt gacagttaat ttaaaaatta tganttaatg ctgcctgtgt ctatggggtt ctgtcttctt tgatagccat ctattcatct ggatcatggg accctctcta atccttccac caatcaaata agctattgct attggtttgg agttgagata tcagtctcgg aaactt &lt;210&gt; 430 &lt;211&gt; 533 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 41362_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 51， 74, 76, 91， 94， 114， 115， 134， 139， 166, 229, 235 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 237, 239..243, 245..249, 254..256, 258, 259, 326..394 &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; 98677.doc -351 -120 180 240 300 360 420 446 gttctgattt gacacactga ttttaatctt cgaatcatga cactgagtgc agaggaggtg gcattccgac agcaggacat acatgttggt gtgaagactg ggacgacact gggtagaatc tagtttttaa ttattattaa tataaaggat caaattaatt taaatatgat tctgaagtct acagaacttt tagttctgtg ctgtctatgt ggacactttg gtaaaatgca aattatgata tggacgttat cattggtctg gtgagatgtt tcatatttgt gacagttaat ttaaaaatta tganttaatg ctgcctgtgt ctatggggtt ctgtcttctt ctattcatct ggatcatggg accctctcta atccttccac caatcaaata agctattgct attggtttgg agttgagata tgatagccat tcagtctcgg aaactt &lt; 210 &gt; 430 &lt; 211 &gt; 533 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 41362_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> 51, 74, 76, 91, 94, 114, 115, 134, 139, 166, 229, 235 &lt; 223> n is a, g, c or t &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; 237 , 239..243, 245..249, 254..256, 258, 259, 326..394 &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; 98677.doc -351-

200533758 &lt;221&gt; misc_feature &lt;222〉 451..467 &lt;223〉n 為 a，g，c 或 t &lt;400〉 430 cacaactggg gcagaattta aagctgcaac acagctggtg atgagaggct ncctcagtcc agtcgctcct tagncnccag gcaccgtggg nccnggatgg ggaactgcaa gcannctctc agctgatggc tgcncagtnc agatgtctgg tggcagagag tccgangcat ggagcgattc cattttatga ctgttgtttt tcacattttc atctttctaa ggtgtgtcnc ttttncnann nnnannnnnt tttnnnannc caaaagtcga tcaatcgcat tcattttaag aaattatacc tttttagtac ttgctgaaga atgatnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnatagac agcacttgtg aaggattgaa tgcaggttcc aggtggaggg aagacgtgga nnnnnnnnnn nnnnnnncat gcagacattt ttaaaagcta tacaaaaaat tgtgagaaga cattggccaa ctctttcaaa gtc &lt;210&gt; 431 &lt;211〉 397 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 41384_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （157)..(191) &lt;223&gt; n 為 a，g，c 或 t 60 120 180 240 300 360 420 480 533 98677.doc -352 - 200533758 &lt;220&gt; &lt;221〉 misc_feature &lt;222〉 （320)..(328) &lt;223&gt; η 為 a，g，c 或 t &lt;400〉 431200533758 &lt; 221 &gt; misc_feature &lt; 222> 451..467 &lt; 223> n is a, g, c or t &lt; 400> 430 cacaactggg gcagaattta aagctgcaac acagctggtg atgagaggct ncctcagtcc agtcgctcct tagncnccag gcaccgtggg nccnggatgg ggaactgcaa gcannctctc agctgatggc tgcncagtnc agatgtctgg tggcagagag tccgangcat ggagcgattc cattttatga ctgttgtttt tcacattttc atctttctaa ggtgtgtcnc ttttncnann nnnannnnnt tttnnnannc caaaagtcga tcaatcgcat tcattttaag aaattatacc tttttagtac ttgctgaaga atgatnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnatagac agcacttgtg aaggattgaa tgcaggttcc aggtggaggg aagacgtgga nnnnnnnnnn nnnnnnncat gcagacattt ttaaaagcta tacaaaaaat tgtgagaaga cattggccaa ctctttcaaa gtc &lt; 210 &gt; 431 &lt; 211> 397 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 41384_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (157) .. (191) &lt; 223 &gt; n is a, g, c or t 60 120 180 240 300 360 420 480 533 98677.doc -352-200533758 &lt; 220 &gt; &lt; 221〉 misc_feature & <222> (320) .. (328) &lt; 223 &gt; η is a, g, c or t &lt; 400> 431

60 120 180 240 300 360 397 ttcttgttta taacagtgcc ttaaggtatg atgtatttct gatggaagcc attttcacat tcatgttctt catggattat ttgttacttg tctaagatgc aatttgattt tatgaagtat atacccttta cccaccagag acagtacaga atccctnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngttattaat ttaaaactcc attattagga ttacatttta aagttttatt tatgaattcc ctttaaaaat gatatttcaa aggtaaaaca atacaatata aagaaaaaaa taaatatatt aataccggcn nnnnnnnncc atttttaacc tcagccttcc ctactgtcac caacaaccaa gctaaataaa gtcaacagcc tgatgtg &lt;210〉 432 &lt;211〉 563 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 41419一at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc—feature &lt;222〉 200, 222, 227, 485 &lt;223&gt; n 為 a，g，c 或 t &lt;40〇&gt; 432 98677.doc •353 - 60 200533758 120 180 240 300 360 420 480 540 56360 120 180 240 300 360 397 ttcttgttta taacagtgcc ttaaggtatg atgtatttct gatggaagcc attttcacat tcatgttctt catggattat ttgttacttg tctaagatgc aatttgattt tatgaagtat atacccttta cccaccagag acagtacaga atccctnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngttattaat ttaaaactcc attattagga ttacatttta aagttttatt tatgaattcc ctttaaaaat gatatttcaa aggtaaaaca atacaatata aagaaaaaaa taaatatatt aataccggcn nnnnnnnncc atttttaacc tcagccttcc ctactgtcac caacaaccaa gctaaataaa gtcaacagcc tgatgtg &lt; 210 〉 432 &lt; 211〉 563 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 41419-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> 200, 222 , 227, 485 &lt; 223 &gt; n is a, g, c or t &lt; 40〇 &gt; 432 98677.doc • 353-60 200533758 120 180 240 300 360 420 480 540 563

ctcattggaa ttttcttcaa gtgttaaagg tacattttca ctaggaaaag aaatcaaata tgcttatgca atatatattt gtgtgttttt ccttaatgtt atatggtata tatgagcctt cttgtttagt ttcttttatc tgctaagttg taccttaatt agagggcaat atatgtttca taaagaagag tctttataan tttgtttgtc agatagtatt tnggaanttg tataataagg atgtttagaa gccatataag tggctttttt taacagatag aatttgtatt tttattgtac tttaaaaaga tttatgtaat aggtatatat ttagtggcca tttattatca atggtaacac aatggagtac taagatggta tttgcacatt taagatatgt tactttacca atttttaatg gtaatcaact ctgctactgg catgatgaaa tagtacataa ctggtcatta attatgaaca tttanttctc cagtgcgttt ttatgaagat ctggttgaaa attgtatttc tatgtaaact caacgatatg tttggttttc ctg &lt;210〉 433 &lt;211〉 424 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 41433—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 26, 32, 35, 42, 231..245 &lt;223&gt; n 為 a, g，c 或 t &lt;400〉 433 caaagtaaaa cttgctgcct gaagancagt anctnccatc angatgagag aactggagga 60 98671doc - 354- 200533758ctcattggaa ttttcttcaa gtgttaaagg tacattttca ctaggaaaag aaatcaaata tgcttatgca atatatattt gtgtgttttt ccttaatgtt atatggtata tatgagcctt cttgtttagt ttcttttatc tgctaagttg taccttaatt agagggcaat atatgtttca taaagaagag tctttataan tttgtttgtc agatagtatt tnggaanttg tataataagg atgtttagaa gccatataag tggctttttt taacagatag aatttgtatt tttattgtac tttaaaaaga tttatgtaat aggtatatat ttagtggcca tttattatca atggtaacac aatggagtac taagatggta tttgcacatt taagatatgt tactttacca atttttaatg gtaatcaact ctgctactgg catgatgaaa tagtacataa ctggtcatta attatgaaca tttanttctc cagtgcgttt ttatgaagat ctggttgaaa attgtatttc tatgtaaact caacgatatg tttggttttc ctg &lt; 210> 433 &lt; 211> 424 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 41433-at HG-U95Av2 &lt; 220 misc-feature &lt; 222〉 26, 32, 35, 42, 231..245 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 433 caaagtaaaa cttgctgcct gaagancagt anctnccatc angatgagag aactggagga 60 98671doc-354- 200533758

gttccttgat ctgtatatac aataacataa tttgtacata tgtaaaataa aattatgcca tagcaagatt gcttaaaata gcaacactct atatttagat tgttaaaata actagtgttg cttggactat tataatttaa tgcatgttag gaaaatttca cattaatatt nnnnnnnnnn nnnnntttgt catctttctt ctattttatt ccctttcaca aaattttatt cctatatagt ttattgacaa taatttcagg ttttgtaaag atgccgggtt ttatattttt atagacaaat aataagcaaa gggagcactg ggttgacttt caggtactaa atacctcaac ctatggtata atgg &lt;210&gt; 434 &lt;211&gt; 607 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 41439—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 50..65, 418..424, 434..437, 439, 440, 445, 578, 580, 581 &lt;223〉n 為 a, g，c 或 &lt;400〉 434 ctgtttctgg taaataccat nnnnncaaat ttgagtagat agatagcagt aaaacattct ttttatttat aatatacatt t atatgatcct cgaaatgata attttaaaca cctaacaaag gtatgatgtg caataaaaca tttgtatgag aaaggtgatt atatctccan nnnnnnnnnn taaagggcta aaagccattc tccaagatct tttttgaaag ggtacagggt gcctatttta 98677.doc -355 - 300 200533758 gtcatggatc aaaatttgtg gggttcattt tggaaactac ataatgtata tacattggta nnnnaaaaaa aaannnnann atcatctctc agaaaggttt cacttatctt ttataaacca acttgta taacttgcag ggctttcttt attttaaact ttggaatcaa ttatgttaaa taataaaatt tttgnatctc aagctatttt tacaatccaa acattatatg gaaacattaa ttgaaaanan ctttttcttc aaatttacaa attgtttctt atttgggagg gttctaattt ggtgccannn catatgttat gtgtcaatgt ttctctgtgt aactgaattt nttctgggga ttttctcttg 360 420 480 540 600 607 &lt;210&gt; 435 &lt;211〉 278 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 41446丄at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_featuregttccttgat ctgtatatac aataacataa tttgtacata tgtaaaataa aattatgcca tagcaagatt gcttaaaata gcaacactct atatttagat tgttaaaata actagtgttg cttggactat tataatttaa tgcatgttag gaaaatttca cattaatatt nnnnnnnnnn nnnnntttgt catctttctt ctattttatt ccctttcaca aaattttatt cctatatagt ttattgacaa taatttcagg ttttgtaaag atgccgggtt ttatattttt atagacaaat aataagcaaa gggagcactg ggttgacttt caggtactaa atacctcaac ctatggtata atgg &lt; 210 &gt; 434 &lt; 211 &gt; 607 &lt; 212 〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223> Probe 41439-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> 50..65, 418..424, 434..437, 439, 440, 445, 578, 580, 581 &lt; 223> n is a, g, c, or &lt; 400> 434 ctgtttctgg taaataccat nnnnncaaat ttgagtagat agatagcagt aaaacattct ttttatttat aatatacatt t atatgatcct cgaaatgata attttaaaca cctaacaaag gtatgatgtg caataaaaca tttgtatgag aaaggtgatt atatctccan nnnnnnnnnn taaagggcta aaagccattc tccaagatct tttttgaaag ggtacagggt gcctatttta 98677.doc -355-300 200533758 gtcatggatc aaaatttgtg gggttcattt tggaaa ctac ataatgtata tacattggta nnnnaaaaaa aaannnnann atcatctctc agaaaggttt cacttatctt ttataaacca acttgta taacttgcag ggctttcttt attttaaact ttggaatcaa ttatgttaaa taataaaatt tttgnatctc aagctatttt tacaatccaa acattatatg gaaacattaa ttgaaaanan ctttttcttc aaatttacaa attgtttctt atttgggagg gttctaattt ggtgccannn catatgttat gtgtcaatgt ttctctgtgt aactgaattt nttctgggga ttttctcttg 360 420 480 540 600 607 &lt; 210 &gt; 435 &lt; 211> 278 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 41446 丄 at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature

&lt;222&gt; 83, 86, 87, 96, 149..182, 216..218 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 435 ctggtgtctc gcaagaagag gtttgcaaag nncagatgta ctgcacctgc ctgctgctcc gggcgtcaga aacagagaga gctggttcct tgnctnnccc gaagtgcann catgtacaaa gcaagtgcaa gtgggntgta nnnnnnnnnn cctggnnntt agagtgcaaa gcaagtgtgc nnnnnnnnnn ttttttttat tgcacctcct ccagggctgt nnnnnnnnnn accaccttga 60 120 180 240 986 &quot;7.doc - 356 - 200533758 cccatttgct acattccttt tcctgtgaaa tatgtgag &lt;210&gt; 436 &lt;211&gt; 518 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 41475-at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 76, 79, 88, 91, 108, 164, 383 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 436 ggaccagccc ttgctctgac tgcggccaag caccacgcag gaggccactc ttgtctctca gcagctgttc ccaggnggna gctccctnct nggcacatgg gggctggnca caatagccca gagggtcaga actggacagc tgcagagacc tgtgcccaga gaanggtctc gacccactca aggacacaca gcaggtccgt ggatgggctg gatgagtgac cagggccagc ctctgtctca ggacattcca gaaggacaag gagatgtctc tccctctccc aaagcaccag cgtccctgcc tcccgtgggc cctgtccggg ttgccctggt gaccccagcc tctgtccact tcctaaccca gggaccctgc acagccagaa ctncctttgg ccctacggat ggccactggc tctggtctaa agtgcctggg cttggtggcc atcaagaggg agccagtcag gcctgtgagg gccgtagacc ttgtatatac cctgcaccag cagtgaccgg gcagagcc &lt;210〉 437 278&lt; 222 &gt; 83, 86, 87, 96, 149..182, 216..218 &lt; 223 &gt; n is a, g, c, or t &lt; 400> 435 ctggtgtctc gcaagaagag gtttgcaaag nncagatgta ctgcacctgc ctgctgctcc gggctgggctgagat catgtacaaa gcaagtgcaa gtgggntgta nnnnnnnnnn cctggnnntt agagtgcaaa gcaagtgtgc nnnnnnnnnn ttttttttat tgcacctcct ccagggctgt nnnnnnnnnn accaccttga 60 120 180 240 986 &quot; 7.doc - 356 - 200533758 cccatttgct acattccttt tcctgtgaaa tatgtgag &lt; 210 &gt; 436 &lt; 211 &gt; 518 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 41475-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 76, 79, 88, 91, 108, 164, 383 &lt; 223 &gt; n is a, g, c or t &lt; 400> 436 ggaccagccc ttgctctgac tgcggccaag caccacgcag gaggccactc ttgtctctca gcagctgttc ccaggnggna gctccctnct nggcacatgg gggctggnca caatagccca gagggtcaga actggacagc tgcagagacc tgtgcccaga gaanggtctc gacccactca aggacacaca gcaggtccgt ggatgggctg gatgagtgac cagggccagc ctctgtctca ggacattcca gaaggacaag gagatgtctc tccctctccc aaagcaccag cgtccctgcc tcccgtgggc cctgtccggg ttgccctggt gaccccagcc tctgtccact tcctaaccca gggaccctgc acagccagaa ctncctttgg ccctacggat ggccactggc tctggtctaa agtgcctggg cttggtggcc atcaagaggg agccagtcag gcctgtgagg gccgtagacc ttgtatatac cctgcaccag cagtgaccgg gcagagcc &lt; 210> 437 278

60 120 180 240 300 360 420 480 98677.doc -357 - 518 200533758 &lt;211〉 406 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 4153〇t HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 51， 103， 106 &lt;223&gt; n 為 a，g，c 或 t60 120 180 240 300 360 420 480 98677.doc -357-518 200533758 &lt; 211〉 406 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 4153〇t HG-U95Av2 &lt; 220> &lt; 221〉 misc_feature &lt; 222〉 51, 103, 106 &lt; 223 &gt; n is a, g, c or t

&lt;400〉 437 60 120 180 240 300 360 406 catccataca ttactgtgtt tggctgaatt ccactctaat atgatgctcc nattatgcac catactgtga tgacctttct actccgaaac ctgctggagc ctnccnttgg ccgtggggtg tcagccaatc actgcttgtt ccacttgttg tacattttat ttttgagtct ttttctttct catatacaga aaaatagtat gaaaataaaa taaatgtatg aaacagtatt aatgcagaaa tgtgctacta atggatgtct gagtcaccag aaattccatt cttaaagagg cggttagcac ctattagacg taacagtgat gtcttttaaa aaatccaaaa gcatattgca acaataagtt tgagactttg tgtgaacaaa gggaaattca gcctcttatg tctttg &lt;210〉 438 &lt;211&gt; 503 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 41554—at HG-U95Av2 &lt;220&gt; 98677.doc - 358 -&Lt; 400> 437 60 120 180 240 300 360 406 catccataca ttactgtgtt tggctgaatt ccactctaat atgatgctcc nattatgcac catactgtga tgacctttct actccgaaac ctgctggagc ctnccnttgg ccgtggggtg tcagccaatc actgcttgtt ccacttgttg tacattttat ttttgagtct ttttctttct catatacaga aaaatagtat gaaaataaaa taaatgtatg aaacagtatt aatgcagaaa tgtgctacta atggatgtct gagtcaccag aaattccatt cttaaagagg cggttagcac ctattagacg taacagtgat gtcttttaaa aaatccaaaa gcatattgca acaataagtt tgagactttg tgtgaacaaa gggaaattca gcctcttatg tctttg &lt; 210〉 438 &lt; 211 &gt; 503 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223> Probe 41554-at HG-U95Av2 &lt; 220 &gt; 98677.doc-358-

200533758 &lt;221&gt; misc_feature &lt;222〉 （329)..(343) &lt;223〉η 為 a，g，c 或 t &lt;400〉 438 gtccacagtt attcaaacaa tggctttttt tgtgatgaga gtatttgtta aaaaaaaaaa aaagacttca agaaaaataa aagttcagtg gagctgcaaa taaatctggt gaataatttc atctttggta atctcccatt tcctgagttc ttcctcaatc caagctgtcc tgtgtagtat ataacatttg ggcattttct ctgatatact atactctcat gttctataaa tttctgtccc gtaattctaa cactttacat tttttctttg ctatcagcta tagctattca tggaagggaa gaatcactaa atacttgtct agttatagnn nnnnnnnnnn nnntcctcct tatccctcga tgcctggctt ggtgtctggc aaacagtcca taattagcag atgttgaaag accgtttaca aagcagaatt tggggattta aagtgcaatg atacaacaaa aagatttaat tacagcttcc agtgttttga ctatgtgaac cat &lt;210〉 439 &lt;211&gt; 434 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 41592_at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222&gt; 89, 91, 93..96, 98..101, 103..120, 241 &lt;223&gt; n 為 a，g, c 或 t 60 120 180 240 300 360 420 480 503 98677.doc -359 · 60 200533758 &lt;400〉 439200533758 &lt; 221 &gt; misc_feature &lt; 222〉 (329) .. (343) &lt; 223〉 η is a, g, c or t &lt; 400> 438 gtccacagtt attcaaacaa tggctttttt tgtgatgaga gtattt ct agat agat ag at ag at ag at ag at a gat tcctgagttc ttcctcaatc caagctgtcc tgtgtagtat ataacatttg ggcattttct ctgatatact atactctcat gttctataaa tttctgtccc gtaattctaa cactttacat tttttctttg ctatcagcta tagctattca tggaagggaa gaatcactaa atacttgtct agttatagnn nnnnnnnnnn nnntcctcct tatccctcga tgcctggctt ggtgtctggc aaacagtcca taattagcag atgttgaaag accgtttaca aagcagaatt tggggattta aagtgcaatg atacaacaaa aagatttaat tacagcttcc agtgttttga ctatgtgaac cat &lt; 210> 439 &lt; 211 &gt; 434 &lt; 212 〉 DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 41592_at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222 &gt; 89, 91, 93..96, 98..101, 103 .. 120, 241 &lt; 223 &gt; n is a, g, c or t 60 120 180 240 300 360 420 480 503 98677.doc -359 · 60 200533758 &lt; 400〉 439

120 180 240 300 360 420 434 agctgtgccg ccagcgcatc gtggccaccg tgggccgcga gaacctggct cgcatccccc tcaaccccgt cctccgcgac tacctgagnt ncnnnncnnn ncnnnnnnnn nnnnnnnnnn ccgccgtgca cgcagcatta actgggatgc cgtgttattt tgttattact tgcctggaac catgtgggta ccctccccgg cctgggttgg agggagcgga tgggtgtagg ggcgaggcgc ntcccgccct cggctggaga cgaggccgca gaccccttct cacctcttga gggggtcctc cccctcctgg tgctccctct gggtccccct ggttgttgta gcagcttaac tgtatctgga gccaggacct gaactcgcac ctcctacctc ttcatgttta catataccca gtatctttgc acaaaccagg ggtt &lt;210〉 440 &lt;211&gt; 532 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 41601 HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （32)..(52) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 440 60 gacccacaag cagatatttg aattacttct tnnnnnnnnn nnnnnnnnnn nnggatgggc tgcatttact gtgtgaagga taaaaatcat tagcctggat tctgatttct ataaattgcc 98677.doc - 360 - 120 180 180120 180 240 300 360 420 434 agctgtgccg ccagcgcatc gtggccaccg tgggccgcga gaacctggct cgcatccccc tcaaccccgt cctccgcgac tacctgagnt ncnnnncnnn ncnnnnnnnn nnnnnnnnnn ccgccgtgca cgcagcatta actgggatgc cgtgttattt tgttattact tgcctggaac catgtgggta ccctccccgg cctgggttgg agggagcgga tgggtgtagg ggcgaggcgc ntcccgccct cggctggaga cgaggccgca gaccccttct cacctcttga gggggtcctc cccctcctgg tgctccctct gggtccccct ggttgttgta gcagcttaac tgtatctgga gccaggacct gaactcgcac ctcctacctc ttcatgttta catataccca gtatctttgc acaaaccagg ggtt &lt; 210〉 440 &lt; 211 &gt; 532 &lt; 212〉 DNA &lt; 213〉 human &lt; 220〉 &lt; 223 &gt; Probe 41601 HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 (32) .. (52) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 440 60 gacccacaag cagatatttg aattacttct tnnnnnnnnn nnnnnnnnnn nnggatgggc tgcatttact gtgtgaagga taaaaatcat tagcctggat tctgatt tct 120 -480.

200533758 attaaaagct ttttttcccc taagaactga aatgtgctca ccagccaaaa cattttaact tgtaaatttt gagggcagtt aaccaaacct gtgactaatc atatctcctc ctacccccca tttccaagga catttgttac tcagatactt gttatactaa tacttgaact tgtaccttat ggtatttgct atcttttaac tagtcatgat attcttatac tttagttaca cttttggaat ttgatacaag gttgagtggg gtgtgtgggt gtatgtatga gtgaaacagt tctcaaaaga atgtaagaaa aaccattttt ataaaattgt gactttttaa aaacatagtc tttgtcattt atagaattaa caagctgctc agggtatatt ttatagctgt agcactgata tc &lt;210&gt; 441 &lt;211&gt; 463 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 41612_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 66..82, 132， 139， 146， 155， 167, 187， 198, 204, 226, 245, 260 &lt;223〉n 為 a，g，c 或 t 240 300 360 420 480 532 &lt;4〇〇&gt; 441 atcttgtttt ttttcnnnnn tttctttgtc tattttncca acactcccat nnnnnnnnnn anacctaanc gttgtttnaa gggtccttca nnttaatttt tgttgnagtt tttnccattg ggctctcatc tattgacctt tgtgncagtg ggtgggttct ttttttcttt ccatggtcct agttttncat tttgtnacac ttccagtcta cactgattgt tttggttttg cttctgtttc 60 120 180 240 98677.doc -361 - 200533758 tttgncttat tttttaacgn ccaaagaaag actctcagag aatagacaac tatattccaa agtcatggtt ctctggtggt ttgtcttgac atttgaatag aaatgttaaa ctatctgggg gaatagaaag cccacagtct tctgagttgt gctacaccaa tatttctatg aacagatctt acaactgaga gtgatctgca gatttttcag agtcatgttc tcc200533758 attaaaagct ttttttcccc taagaactga aatgtgctca ccagccaaaa cattttaact tgtaaatttt gagggcagtt aaccaaacct gtgactaatc atatctcctc ctacccccca tttccaagga catttgttac tcagatactt gttatactaa tacttgaact tgtaccttat ggtatttgct atcttttaac tagtcatgat attcttatac tttagttaca cttttggaat ttgatacaag gttgagtggg gtgtgtgggt gtatgtatga gtgaaacagt tctcaaaaga atgtaagaaa aaccattttt ataaaattgt gactttttaa aaacatagtc tttgtcattt atagaattaa caagctgctc agggtatatt ttatagctgt agcactgata tc &lt; 210 &gt; 441 &lt; 211 &gt; 463 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220 &gt; &lt; 223 &gt; Probe 41612_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222〉 66..82, 132, 139, 146, 155, 167, 187, 198, 204, 226, 245, 260 &lt; 223> n is a, g, c or t 240 300 360 420 480 532 &lt; 4〇〇 &gt; 441 atcttgtttt ttttcnnnnn tttctttgtc tattttncca acactcccat nnnnnnnnnntt anaccnaan g gggtccttca nnttaatttt tgttgnagtt tttnccattg ggctctcatc tattgacctt tgtgncagtg ggtgggttct ttttttcttt ccatggtcct agttttncat tttgtnacac ttccagt cta cactgattgt tttggttttg cttctgtttc 60 120 180 240 98677.doc -361 - 200533758 tttgncttat tttttaacgn ccaaagaaag actctcagag aatagacaac tatattccaa agtcatggtt ctctggtggt ttgtcttgac atttgaatag aaatgttaaa ctatctgggg gaatagaaag cccacagtct tctgagttgt gctacaccaa tatttctatg aacagatctt acaactgaga gtgatctgca gatttttcag agtcatgttc tcc

&lt;210〉 442 &lt;211&gt; 347 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 41635_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （133)..(149) &lt;223&gt; n 為 a, g，c 或 t &lt;4〇〇&gt; 442 gctctatatt acttgcttga gccttaatca atgtggtttt attcaatggt ttgttctttg aatggttgca aaaactgtag ataatcttac tgaggactgt acaaacatga aggtgtggta tcaaacttca ggnnnnnnnn nnnnnnnnna ttataaacat teatttcaca actagattgt ataaggatat tagctgtgat gagactcact gcattatttt ttttagtgaa ttttatgaaa tccccgttcc attcaacagg cacatgttta aaagagcttt gtcgttggtg ttaatggggg aatgtgttcc ttcattgtat ttgggccttt tgtattgeae tettgat &lt;210&gt; 443 9S677.doc -362- 200533758 &lt;211&gt; 357 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 41654_at HG-U95Av2 &lt;220&gt; &lt;221&gt; mi sc一 feature &lt;222〉 (141) ..(167) &lt;223&gt; n為 a，g，c 或 t&lt; 210> 442 &lt; 211 &gt; 347 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 41635_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> (133 ) .. (149) &lt; 223 &gt; n is a, g, c or t &lt; 4〇〇 &gt; 442 gctctatatt acttgcttga gccttaatca atgtggtttt attcaatggt ttgttctttg aatggttgca aaaactgtag ataatcttac tgaggactgt acaaacatga aggtgtggta tcaaacttca ggnnnnnnnn nnnnnnnnna ttataaacat teatttcaca actagattgt ataaggatat tagctgtgat gagactcact gcattatttt ttttagtgaa ttttatgaaa tccccgttcc attcaacagg cacatgttta aaagagcttt gtcgttggtg ttaatggggg aatgtgttcc ttcattgtat ttgggccttt tgtattgeae tettgat &lt; 210 &gt; at &lt; 211 &gt; 212 &gt; lt & 211 -U95Av2 &lt; 220 &gt; &lt; 221 &gt; mi sc-feature &lt; 222〉 (141) .. (167) &lt; 223 &gt; n is a, g, c or t

&lt;4〇〇&gt; 443 60 120 180 240 300 357 aaaggctgaa catcaatgcg gccaaatcta gtttcctccc agaagatgaa aagagggagc ttctcgacct gctctataaa gcctatggga tgccaccttc agcctctgca gggcagaacc tctgaagacg ccactcctcc nnnnnnnnnn nnnnnnnnnn nnnnnnnact ctgtggggct gagcaacatt tttacattta ttccttccaa gaagaccatg atctcaatag tcagttactg atgctcctga accctatgtg tccatttctg cacacacgta tacctcggca tggccgcgtc acttctctga ttatgtgccc tggccaggga ccagcgccct tgcacatggg catggtt &lt;210〉 444 &lt;211&gt; 240 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 41656—at HG-U95Av2 &lt;220&gt; &lt;221〉mi sc一feature &lt;222〉 （199)..(199) 98677.doc 363 - 200533758 &lt;223〉η 為 a, g，c 或 t &lt;400&gt; 444 tgtacccgcg actaactaga cttttctgct gttgtgcaaa gttcagtttc ttctcagcaa catcaaggat atatgaagaa aaggaaataa aaaactgtaa agtcaaaaga gatgcctggt ggaacttatt cgtgctatca gggcattgat agtttgaatg tttttattac ttatgcaaaa ttgcacatac tcctctatnc tgattttatc atgaaaactg tcatgtgtca tgctaatgga&Lt; 4〇〇 &gt; 443 60 120 180 240 300 357 aaaggctgaa catcaatgcg gccaaatcta gtttcctccc agaagatgaa aagagggagc ttctcgacct gctctataaa gcctatggga tgccaccttc agcctctgca gggcagaacc tctgaagacg ccactcctcc nnnnnnnnnn nnnnnnnnnn nnnnnnnact ctgtggggct gagcaacatt tttacattta ttccttccaa gaagaccatg atctcaatag tcagttactg atgctcctga accctatgtg tccatttctg cacacacgta tacctcggca tggccgcgtc acttctctga ttatgtgccc tggccaggga ccagcgccct tgcacatggg catggtt &lt; 210> 444 &lt; 211 &gt; 240 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 41656-at HG-U95Av2 &lt; 220 &gt; &lt; 221> mi sc-feature &lt; 222 〉 (199) .. (199) 98677.doc 363-200533758 &lt; 223> η is a, g, c or t &lt; 400 &gt; 444 tgtacccgcg actaactaga cttttctgct gttgtgcaaa gttcagtttc ttctcagatt gatcat gat aat gat agat gat agat gat ttatgcaaaa ttgcacatac tcctctatnc tgattttatc atgaaaactg tcatgtgtca tgctaatgga

&lt;210〉 445 &lt;211&gt; 515 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 41677—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 33..48, 130， 131， 133..136， 140， 142·.147, 232, 238 &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 254, 270, 393, 458..472 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 445 agcaagctca cctcctgcgc tgccttggan ccaggcctct gagggagcag ncnnnncccn cagaagtccc gttctccgca gnnnnnnagg agnnnnnnnn ttcccatggg agagaccaaa nnnnnnnngc caccacctgc ggcttctgag cgggtcggcg ctgcctgtcg caggattttt 98677.doc -364- 240 200533758 atttcattac agtgtgagct gcctggaata catgtggtaa tgaaataaaa anccctgncc ccgaatcttc cgtnccctca tcctaacttn cagttcacag agaaaagtga catacccaaa gctctctgtc aattacaagg cttctcctgg cgtgggagac gtctacaggg aagacaccag cgtttgggct tctaaccacc ctgtctccag ctnctctgca cacatggaca gggacctggg aaaggtggga gagatgctga gcccagcgaa tcctctcnnn nnnnnnnnnn nngaagaaga aaactcaact cagtgccatt ttacgaatat atgcg 300 360 420 480 515&lt; 210〉 445 &lt; 211 &gt; 515 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 41677-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> 33..48, 130, 131, 133..136, 140, 142 · .147, 232, 238 &lt; 223> n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 254, 270, 393, 458..472 &lt; 223 &gt; n is a, g, c or t &lt; 400> 445 agcaagctca cctcctgcgc tgccttggan ccaggcctct gagggagcag ncnnnncccn cagaagtccc gttctccgca gnnnnnnagg agnnnnnnnn ttcccatggg agagaccaaa nnnnnnnngc caccacctgc ggcttctgag cgggtcggcg ctgcctgtcg caggattttt 98677.doc - 364- 240 200533758 atttcattac agtgtgagct gcctggaata catgtggtaa tgaaataaaa anccctgncc ccgaatcttc cgtnccctca tcctaacttn cagttcacag agaaaagtga catacccaaa gctctctgtc aattacaagg cttctcctgg cgtgggagac gtctacaggg aagacaccag cgtttgggct tctaaccacc ctgtctccag ctnctctgca cacatggaca gggacctggg aaaggtggga gagatgctga gcccagcgaa tcctctcnnn nnnnnnnnnn nngaagaaga aaactcaact cagtgccatt ttacgaatat atgcg 300 360 420 480 515

&lt;210&gt; 446 &lt;211〉 580 &lt;212&gt; DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 41711—at HG-U95Av2 &lt;220〉 &lt;221&gt; miscjeature &lt;222&gt; 96..117, 119, 122, 191, 192, 222..245&lt; 210 &gt; 446 &lt; 211> 580 &lt; 212 &gt; DNA &lt; 213> human &lt; 220> &lt; 223 &gt; Probe 41711-at HG-U95Av2 &lt; 220> &lt; 221 &gt; miscjeature &lt; 222 &gt; 96. .117, 119, 122, 191, 192, 222..245

&lt;223〉n 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 267, 480, 494, 495, 503..547 &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 446 catcccagtg ttatgtaaag atggtgtgcc tgagggagcc cccacagctg gtgctgggcc tgcatttcct tggccccaac gcaggcgaag ttactnnnnn nnnnnnnnnn nnnnnnnant 60 120 98677.doc -365 - 180 180&lt; 223> n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 267, 480, 494, 495, 503..547 &lt; 223> n is a, g, c or t &lt; 400 &gt; 446 catcccagtg ttatgtaaag atggtgtgcc tgagggagcc cccacagctg gtgctgggcc tgcatttcct tggccccaac gcaggcgaag ttactnnnnn nnnnnnnnnn nnnnnnnant 60 120 98677.doc -365-180 180

200533758 gnggggcttc ctatgcgcag gtgatgcgga ccgtgggtat ccatcccaca tgctctgagg aggtagtcaa nntgcgcatc tccaagcgct caggcctgga cnnnnnnnnn nnnnnnnnnn nnnnntaagc gccatccctg caggccnagg gcacacggtg cgcccgccgc cagctcctcg gaggccagac ccaggatggc tgcaggccag gtttgggggg cctcaaccct ctcctggagc gcctgtgaga tggtcagcgt ggagcgcaag tgctggacag gtggcccgtg tgccccacag ggatggctca ggggactgtc cacctcaccc ctgcacctct cagcctctgc cgccgggcan ccccccccag gctnntggtg ccnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntcc gagccccctg gcatttctgc aatgcaaata &lt;210〉 447 &lt;211&gt; 193 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 41742^s__at HG-U95Av2 240 300 360 420 480 540 580200533758 gnggggcttc ctatgcgcag gtgatgcgga ccgtgggtat ccatcccaca tgctctgagg aggtagtcaa nntgcgcatc tccaagcgct caggcctgga cnnnnnnnnn nnnnnnnnnn nnnnntaagc gccatccctg caggccnagg gcacacggtg cgcccgccgc cagctcctcg gaggccagac ccaggatggc tgcaggccag gtttgggggg cctcaaccct ctcctggagc gcctgtgaga tggtcagcgt ggagcgcaag tgctggacag gtggcccgtg tgccccacag ggatggctca ggggactgtc cacctcaccc ctgcacctct cagcctctgc cgccgggcan ccccccccag gctnntggtg ccnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntcc gagccccctg gcatttctgc aatgcaaata &lt; 210 〉 447 &lt; 211 &gt; 193 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 41742 ^ s__at HG-U95Av2 240 300 360 420 480 540 580

&lt;4〇〇&gt; 447 gcagtccttg ggcttacctt gattcattcc cgtgatggat atggagatgc gttcaaagag tgccccaagt tgc agagtcgtca gagctgagga gtggagaggt tggggcgaga cagggactgg tctgcctgac acaagtgact cggcaacagc atagacacgt ctgaccagca ggaatattcc tacagattca 60 120 180 193&lt; 4〇〇 &gt; 447 gcagtccttg ggcttacctt gattcattcc cgtgatggat atggagatgc gttcaaagag tgccccaagt tgc agagtcgtca gagctgagga gtggagaggt tggggcgaga 60cacggat acaagggatcacaggat

&lt;210〉 448 &lt;211&gt; 493 &lt;212&gt; DNA 98677.doc -366 - 200533758 &lt;213〉人類 &lt;220〉 &lt;223〉Probe 41743J—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; 37..73, 104, 106..166, 193..242 &lt;223&gt; n 為 a，g，c 或 t&lt; 210> 448 &lt; 211 &gt; 493 &lt; 212 &gt; DNA 98677.doc -366-200533758 &lt; 213〉 Human &lt; 220〉 &lt; 223〉 Probe 41743J-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; 37..73, 104, 106..166, 193..242 &lt; 223 &gt; n is a, g, c or t

&lt;400〉 448 actggaactg nnnnnnnnnn nnnnnnnnnn aaggagcaac nnaggcaggc gaccagcagg aatattccga cagattcacg ggtaaatgtc gcagagaagg nnngcaggaa nnnnnnnnnn tgnnnnnnnn agtccttgat cttaccttgt ttcattcctg tgatggattg aga ctctggcttc gaggacctgg nnnnnnnnnn nnnnnnnnnn ggagatgcag tcaaagagga ccccaagtgt catcatttaa caaacannnn aaaccatgac nnnnnnnnnn nnnnnnnnnn agtcgtcatg gctgaggaca ggagaggttc gtgttgatgt nnnnnnnnnn catncnnnnn nnnnnnaaat nnnnnnnnnn gggcgagaac gggactggcg tgcctgacat atcacctccc nnnnnnnnnn nnnnnnnnnn tcatgaggaa nnnnnnnnnn aagtgactct gcaacagcgg agacacgtta caaaactgtt 60 120 180 240 300 360 420 480 493 &lt;210〉 449 &lt;211&gt; 206 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 41816一at HG-U95Av2 98677.doc -367 - 200533758 &lt;4〇〇&gt; 449 tctctcctgt ttcctggcgg tcttgggggg aacgggcctt gtaaatgtca gcacactcag ccgaggaggg tttcacttag cgccccaccc gaccgtgcct cggctgctct aagctg ctgtttcatg cacagggccc gtcatgagaa tgggcactaa actccctgcc tgtacggccc cacgtgtgcg tatgcctccc gtggatgatt&Lt; 400> 448 actggaactg nnnnnnnnnn nnnnnnnnnn aaggagcaac nnaggcaggc gaccagcagg aatattccga cagattcacg ggtaaatgtc gcagagaagg nnngcaggaa nnnnnnnnnn tgnnnnnnnn agtccttgat cttaccttgt ttcattcctg tgatggattg aga ctctggcttc gaggacctgg nnnnnnnnnn nnnnnnnnnn ggagatgcag tcaaagagga ccccaagtgt catcatttaa caaacannnn aaaccatgac nnnnnnnnnn nnnnnnnnnn agtcgtcatg gctgaggaca ggagaggttc gtgttgatgt nnnnnnnnnn catncnnnnn nnnnnnaaat nnnnnnnnnn gggcgagaac gggactggcg tgcctgacat atcacctccc nnnnnnnnnn nnnnnnnnnn tcatgaggaa nnnnnnnnnn aagtgactct gcaacagcgg agacacgtta caaaactgtt 60 120 180 240 300 360 420 480 493 &lt; 210〉 449 &lt; 211 &gt; 206 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 41816-at HG-U95Av 98 .doc -367-200533758 &lt; 4〇〇 &gt; 449 tctctcctgt ttcctggcgg tcttgggggg aacgggcctt gtaaatgtca gcacactcag ccgaggaggg tttcacttag cgccccaccc gaccgtctcgcc tgggcctgggcc tgggcctggcc

&lt;210〉 450 &lt;211&gt; 443 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 41831_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc—feature &lt;222&gt; (247)..(247) &lt;223〉n 為 a, g，c 或 t • &lt;400&gt; 450 cgtccagcac gaaggccacg ctgtacccgc cgatcctgaa cccgccgccc tccccggcca cggacccctc cctgtacaac atggacatgt tctactcttc aaacattccg gccactgcga gaccgtacag gccctacatc attcgaggaa tggcgccccc gacgacgccc tgcagcaccg acgtgtgtga cagcgactac agcgccagcc gctggaaggc cagcaagtac tacctggatt tgaactngga ctcagacccc tatccacccc cacccacgcc ccacagccag tacctgtcgg cggaggacag ctgcccgccc tcgcccgcca ccgagaggag ctacttccat ctcttcccgc 98677.doc -368 - 420 200533758 443 cccctccgtc cccctgcacg gactcatcct gacctcggcc gggccactct ggcttctctg tgcccctgta aatagtttta aat &lt;210〉 451 &lt;211&gt; 145 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 425—at HG-U95Av2&lt; 210> 450 &lt; 211 &gt; 443 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 41831_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222 &gt; (247 ) .. (247) &lt; 223> n is a, g, c or t • &lt; 400 &gt; 450 cgtccagcac gaaggccacg ctgtacccgc cgatcctgaa cccgccgccc tccccggcca cggacccctc cctgtacaac atggacatgt tctactcttc aaacattccg gccactgcga gaccgtacag gccctacatc attcgaggaa tggcgccccc gacgacgccc tgcagcaccg acgtgtgtga cagcgactac agcgccagcc gctggaaggc cagcaagtac tacctggatt tgaactngga ctcagacccc tatccacccc cacccacgcc ccacagccag tacctgtcgg cggaggacag ctgcccgccc tcgcccgcca ccgagaggag ctacttccat ctcttcccgc 98677.doc -368 - 420 200533758 443 cccctccgtc cccctgcacg gactcatcct gacctcggcc gggccactct ggcttctctg tgcccctgta aatagtttta aat &lt; 210> 451 &lt; 211 &gt; 145 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 425—at HG-U95Av2

&lt;400〉 451 60 120 145 gctctcacct catcagcagt gaccagtgtg gccaaagtgg tcagggtggc ctctggctct gccgtagttt tgcccctggc caggattgct acagttgtga ttggaggagt tgtggccatg gcggctgtgc ccatggtgct cagtg &lt;210&gt; 452 &lt;211&gt; 299 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 463_g_at HG-U95Av2 &lt;400〉 452 ttgccaaact ctggcaagaa gaatcgactg tgttcaaagg gcgcaaagat gcacccgtgc cctgcgacag catccccttg attcgccagg tgtgtcttat gcagacaaag gaaagtaccg agtatcgaga ccaatcccga tctggcgtct atggagagcg ggactttgtg ccagaagggt ggatctagtc gctcatgaaa ctcaccgtga aagattagga atggtgatcc tccccacatt 60 120 180 240 98677.doc - 509 -&lt; 400> 451 60 120 145 gctctcacct catcagcagt gaccagtgtg gccaaagtgg tcagggtggc ctctggctct gccgtagttt tgcccctggc caggattgct acagttgtga ttggaggagt &220; &lt;220; &lt; 210 &212; Probe 463_g_at HG-U95Av2 &lt; 400> 452 ttgccaaact ctggcaagaa gaatcgactg tgttcaaagg gcgcaaagat gcacccgtgc cctgcgacag catccccttg attcgccagg tgtgtcttat gcagacaaag gaaagtaccg agtatcgaga ccaatcccga tctggcgtct atggagagcg ggactttgtg ccagaagggt ggatctagtc gctcatgaaa ctcaccgtga aagattagga atggtgatcc tccccacatt 60 120 180 240 98677.doc - 509 -

200533758 gcacaaaccc agcactttgt gtccagccac atcatatcac agtatcagtt aaggagctt &lt;210&gt; 453 &lt;211&gt; 180 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 464—s_at HG-U95Av2 &lt;400〉 453 gggcctagca gtcttcacct ctgagtcagg ctaggggcct ccccttctca tcctccccac ccccccgcca aggttctcac actggcctgg gcttgggtgc ccatatagga ggtctgtatg ttcaccaaca gtgcggaggg gtcacacatt gcaaaacact gcccagaaca gtaaaaagag &lt;210&gt; 454 &lt;211&gt; 77 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 481—at HG-U95Av2 &lt;400〉 454 gaagacttgg ccaagaagta ttttgctcag atagttcatg ctatatctta ttgccataaa ctccatgtgg ttcacag &lt;210&gt; 455 &lt;211〉 564 &lt;212&gt; DNA &lt;213&gt; 人類 98677.doc -3 70 - 60 60200533758 gcacaaaccc agcactttgt gtccagccac atcatatcac agtatcagtt aaggagctt &lt; 210 &gt; 453 &lt; 211 &gt; 180 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 464-s_at ga-ctcgt + ctct> ctvt> tcct> tcct ctaggggcct ccccttctca tcctccccac ccccccgcca aggttctcac actggcctgg gcttgggtgc ccatatagga ggtctgtatatg ttcaccaaca gtgcggaggg gtcacacatt gcaaaacact &lt; 210 &gt;212;> &lt;212;> &lt; 212 &lt; 400〉 454 gaagacttgg ccaagaagta ttttgctcag atagttcatg ctatatctta ttgccataaa ctccatgtgg ttcacag &lt; 210 &gt; 455 &lt; 211〉 564 &lt; 212 &gt; DNA &lt; 213 &gt; human 98677.doc -3 70-60 60

200533758 &lt;220&gt; &lt;223&gt; Probe 535—s—at HG-U95Av2 &lt;400&gt; 455 tgatttcaaa ttgaactcct ccattgtgga acccaaggag ccagccccag aaacagctga tggcccctac ctggtgatcg tggaacagcc taagcagaga ggcttccgat ttcgatatgg ctgtgaaggc ccctcccatg gaggactgcc cggtgcctcc agtgagaagg gccgaaagac ctatcccact gtcaagatct gtaactacga gggaccagcc aagatcgagg tggacctggt aacacacagt gacccacctc gtgctcatgc ccacagtctg gtgggcaagc aatgctcgga gctggggatc tgcgccgttt ctgtggggcc caaggacatg actgcccaat ttaacaacct gggtgtcctg catgtgacta agaagaacat gatggggact atgatacaaa aacttcagag gcagcggctc cgctctaggc cccagggcct tacggaggcc gagcagcggg agctggagca agaggccaaa gaactgaaga aggtgatgga tctgagtata gtgcggctgc gcttctctgc cttccttaga gccagtgatg gctc &lt;210&gt; 456 &lt;211&gt; 180 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 543一g—at HG-U95Av2 &lt;400&gt; 456 gaatatgtca tagttctgag ctgccagtgg accgcccttt tcccctacca atattaggtg atcccgtttt ccccatgaca atgttgtagt gtcccccacc cccacccccc tggccttggt 120 180 240 300 360 420 480 540 564 60 98677.doc -371 - 120 200533758 gcctcttgta tccctagtgc tgcatagccc ggcatttgca cggtttcgaa gtcattaaac 180 &lt;210&gt; 457 &lt;211&gt; 241 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 544一at HG-U95Av2200533758 &lt; 220 &gt; &lt; 223 &gt; Probe 535-s-at HG-U95Av2 &lt; 400 &gt; 455 tgatttcaaa ttgaactcct ccattgtgga acccaaggag ccagccccag aaacagctga tggcccctac ctggtgatcg tggaacagcc taagcagaga ggcttccgat ttcgatatgg ctgtgaaggc ccctcccatg gaggactgcc cggtgcctcc agtgagaagg gccgaaagac ctatcccact gtcaagatct gtaactacga gggaccagcc aagatcgagg tggacctggt aacacacagt gacccacctc gtgctcatgc ccacagtctg gtgggcaagc aatgctcgga gctggggatc tgcgccgttt ctgtggggcc caaggacatg actgcccaat ttaacaacct gggtgtcctg catgtgacta agaagaacat gatggggact atgatacaaa aacttcagag gcagcggctc cgctctaggc cccagggcct tacggaggcc gagcagcggg agctggagca agaggccaaa gaactgaaga aggtgatgga tctgagtata gtgcggctgc gcttctctgc cttccttaga gccagtgatg gctc &lt; 210 &gt; 456 &lt; 211 &gt; 180 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 543-g-at HG-U95Av2 &lt; 400 &gt; 456 gaatatgtca tagttctgag ctgccagtgg accgcccttt tcccctacca atattaggtg atcccgtttt ccccatgaca atgttgtagt gtccc cc cccccccc540 cccccccc540 64 60 98677.doc -371-120 200533758 gcctcttgta tccctagtgc tgcatagccc ggcatttgca cggtttcgaa gtcattaaac 180 &lt; 210 &gt; 457 &lt; 211 &gt; 241 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &544; -U95Av2

&lt;4〇〇&gt; 457 ggtgaagacc ttgctgctaa atgctgctca gaacaccatg gagccacccc tgaccccgcc cagcccagca gggccgggac tgtcacttgg tgatacagct ctgcagaacc tggagcagct gctagacggg ccagaagccc agggcagctg ggcagagctg gcagagcgtc tggggctgcg cagcctggta gacacgtacc gacagacaac ctcacccagt ggcagcctcc tgcgcagcta c 60 120 180 240 241&Lt; 4〇〇 &gt; 457 ggtgaagacc ttgctgctaa atgctgctca gaacaccatg gagccacccc tgaccccgcc cagcccagca gggccgggac tgtcacttgg tgatacagct ctgcagaacc tggagcagct gctagacggg ccagaagccc agggcagctg ggcagagctg gcagagcgtc tggggctgcg cagcctggta gacacgtacc gacagacaac ctcacccagt ggcagcctcc tgcgcagcta c 60 120 180 240 241

&lt;210&gt; 458 &lt;211&gt; 338 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 545一g—at HG-U95Av2 &lt;400&gt; 458 agtggcagcc tcctgcgcag ctacgagctg gctggcgggg acctggcagg tctactggag gccctgtctg acatgggcct agaggaggga gtgaggctgc tgaggggtcc agaaacccga gacaagctgc ccagcacaac agaggtgaag gaagacagtg cgtacgggag ccagtcagtg 60 120 9867&quot;\doc - 372- 180 200533758 gagcagaagg cagagaagct gggcccaccc cctgagccac caggagggct ctgccacggg cacccccagc ctcaggtgca ctgacctgct gcctgccccc agcccccttc ccggaccccc tgtacagcgt ccccacctat ttcaaatctt atttaaca &lt;210&gt; 459 &lt;211&gt; 547 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; ® &lt;223〉 Probe 570_at HG-U95Av2 &lt;400&gt; 459 actgacactg gactcgtacc aggccccggg ccccggggat ggaggcaccg ccagccttgt gggcagcaac atgttcccca atcattaccg cgaggcggcc tttgggggcg gcctcctatc cccggggcct gaagccacgt agccccgcga tgccagagga ggggcactgg gtggggaggg aggtggagga gccgtgcaat cccaaccagg atgtctagca cccccatccc cttggccctt cctcatgctt ctgaagtgga catattcagc cttggcgaga agctccgttg cacgggtttc&lt; 210 &gt; 458 &lt; 211 &gt; 338 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 545-g-at HG-U95Av2 &lt; 400 &gt; 458 agtggcagcc tcctgcgcag ctacgagctg gctggcgggggggtggggt acct agaggaggga gtgaggctgc tgaggggtcc agaaacccga gacaagctgc ccagcacaac agaggtgaag gaagacagtg cgtacgggag ccagtcagtg 60 120 9867 &quot; \ doc - 372- 180 200533758 gagcagaagg cagagaagct gggcccaccc cctgagccac caggagggct ctgccacggg cacccccagc ctcaggtgca ctgacctgct gcctgccccc agcccccttc ccggaccccc tgtacagcgt ccccacctat ttcaaatctt atttaaca &lt; 210 &gt; 459 &lt; 211 &gt; 547 &lt; 212 > DNA &lt; 213 &gt; human &lt; 220 &gt; ® &lt; 223> Probe 570_at HG-U95Av2 &lt; 400 &gt; 459 actgacactg gactcgtacc aggccccggg ccccggggat ggaggcaccg ccagccttgt gggcagcaac atgttcccca atcattaccg cgaggcggcc tttgggggcg gcctcctatc cccggggcct gaagccacgt agccccgcga tgccagagga ggggcactgg gtggggaggg aggtggagga gccgtgcaat cccaaccagg atgtctagca cccccatccc cttggccctt cctcatgctt ctgaagtgga catattcagc cttggcgaga agctccgttg cac gggtttc

cccttgagcc cattttacag atgaggaaac tgagtccgga gaggaaaagg gacatggctc ccgtgcacta gcttgttaca gctgcctctg tccccacatg tgggggcacc ttctccagta ggattcggaa aagattgtac atatgggagg agggggcaga ttcctggccc tccctcccca gacttgactt gaaggtgggg ggtaggttgg ttgttcagag tcttcccaat aaagatgagt ttttgag &lt;210&gt; 460 98677.doc - 373 - 200533758 &lt;211〉 421 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 574—s—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc^feature &lt;222&gt; (120)..(121) &lt;223〉n 為 a，g，c 或 tcccttgagcc cattttacag atgaggaaac tgagtccgga gaggaaaagg gacatggctc ccgtgcacta gcttgttaca gctgcctctg tccccacatg tgggggcacc ttctccagta ggattcggaa aagattgtac atatgggagg agggggcaga ttcctggccc tccctcccca gacttgactt gaaggtgggg ggtaggttgg ttgttcagag tcttcccaat aaagatgagt ttttgag &lt; 210 &gt; 460 98677.doc - 373 - 200533758 &lt; 211> 421 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223> Probe 574—s-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc ^ feature &lt; 222 &gt; (120) .. (121) &lt; 223> n is a, g, c or t

&lt;221&gt; misc_feature &lt;222〉 （264)..(265) &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （374)..(375) &lt;223&gt; η 為 a，g，c 或 t&lt; 221 &gt; misc_feature &lt; 222〉 (264) .. (265) &lt; 223 &gt; η is a, g, c or t &lt; 220〉 &lt; 221 &gt; misc ^ feature &lt; 222> (374) .. (375) &lt; 223 &gt; η is a, g, c or t

&lt;400〉 460 actctgagca agaactgccc ncagccctgg caactacaga tcgctttctg tttttattgg agtcccagat aagtttgaag tgtggtgtgg agagtttgag ctcttccaca aagactcatt atactacaac gacaaaccga tttaaagatt gatgatgcta ccanntaatg gaacatatgc tcaatgcaat aggtgatcat cagtaggagt ttaagaaagc tttcttggag aagaatatgc ctttaacatg catccaggcc ttctggaaac ccacatagag acatcccaca ctgttcctgt ttgaatacca tgccgtggtn ctatctttac aaggatttta atgggctctg gatgtggagg 60 120 180 240 300 360 986，- ioc -374 - 200533758 aaattttccg caannttcga ttttcatttg agcagccaga tggtagagcg cagatgccca 420 c 421 &lt;210〉 461 &lt;211&gt; 577 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 576—at HG-U95Av2 Φ &lt;400&gt; 461&Lt; 400> 460 actctgagca agaactgccc ncagccctgg caactacaga tcgctttctg tttttattgg agtcccagat aagtttgaag tgtggtgtgg agagtttgag ctcttccaca aagactcatt atactacaac gacaaaccga tttaaagatt gatgatgcta ccanntaatg gaacatatgc tcaatgcaat aggtgatcat cagtaggagt ttaagaaagc tttcttggag aagaatatgc ctttaacatg catccaggcc ttctggaaac ccacatagag acatcccaca ctgttcctgt ttgaatacca tgccgtggtn ctatctttac aaggatttta atgggctctg gatgtggagg 60 120 180 240 300 360 986, - ioc -374-200533758 aaattttccg caannttcga ttttcatttg agcagccaga tggtagagcg cagatgccca 420 c 421 &lt; 210> 461 &lt; 211 &gt; 577 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223> Probe-95U-576-at &lt; 400 &gt; 461

atcggcgtgc tgcgggatca gcaacgctac cacgaagaca ttttcgggct cacgctgcgc 60 acccaggagg tgacaagccg catacgcacc cagagctttt ccttgcagga gcgtcagttg 120 cggggcgcag tgccctgggc gttcgaccct cccggctcag acaccaacag cccctgagag 180 ccgcctggct ttcccttcca gttccgggag agcggctgcc cgactcaggt ccgcccgacc 240 aggatcagcc ccgctcctcc cctcttgagg tggtgccttc tcacatctgt ccagaggctg 300 caaggattea gcattattcc tccaggaagg agcaaaacgc ctcttttccc tctctaggcc 360 tgttgcctcg ggcctgggtc cgccttaatc tggaaggccc ctcccagcag cggtacccca 420 gggcctactg ccacccgctt cctgtttctt agtccgaatg ttagattcct cttgcctctc 480 tcaggagtat cttacctgta aagtetaate tctaaatcaa gtatttatta ttgaagattt 540 accataaggg actgtgccag atgttaggag aactact 5ΊΊatcggcgtgc tgcgggatca gcaacgctac cacgaagaca ttttcgggct cacgctgcgc 60 acccaggagg tgacaagccg catacgcacc cagagctttt ccttgcagga gcgtcagttg 120 cggggcgcag tgccctgggc gttcgaccct cccggctcag acaccaacag cccctgagag 180 ccgcctggct ttcccttcca gttccgggag agcggctgcc cgactcaggt ccgcccgacc 240 aggatcagcc ccgctcctcc cctcttgagg tggtgccttc tcacatctgt ccagaggctg 300 caaggattea gcattattcc tccaggaagg agcaaaacgc ctcttttccc tctctaggcc 360 tgttgcctcg ggcctgggtc cgccttaatc tggaaggccc ctcccagcag cggtacccca 420 gggcctactg ccacccgctt cctgtttctt agtccgaatg ttagattcct cttgcctctc 480 tcaggagtat cttacctgta aagtetaate tctaaatcaa gtatttatta ttgaagattt 540 accataaggg actgtgccag atgttaggag aactact 5ΊΊ

&lt;210&gt; 462 &lt;211&gt; 344 &lt;212&gt; DNA 98677.doc -375 200533758 &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 583—s—at HG-U95Av2&lt; 210 &gt; 462 &lt; 211 &gt; 344 &lt; 212 &gt; DNA 98677.doc -375 200533758 &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 583—s-at HG-U95Av2

&lt;400&gt; 462 tgcccatcta cagtaactgc ataatttgta ctctatattt ttaggaaaat tattcccttt tgtcccttgc catcaagatg catatgtaaa agattgttaa ttcacattaa cacaaaattt tgtgagcaag agagaactgg ataaaattat aataactagt tatttgctga tattcctata aagtcaaagt aggagttcct gccatagcaa gttgcttgga cagctgacct tagtttattg aaaacttgct tgatctgtat gattgcttaa ctattataat ttgtcatctt acaa gcctgaagaa atacaataac aatagcaaca ttaatgcatg tcttctattt &lt;210〉 463 &lt;211&gt; 325 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 φ &lt;223〉 Probe 590—at HG-U95Av2 &lt;400〉 463 tccgtggcaa aggccacagc gcctggctgt cgaagatgtt tggtgtcggt tgagactctg cacattcaac gctggacttg ggagatctat gttgctgtcc cactatgaga agcacggctg atgtctcgcg gagcctgtgt ctgttcgtga ccttcgggaa acagagagga gtggcaacat cggacagcca catctgtcct ggcagcccct tggccaccgc ctttcacaaa gatggtcatc gctctgcttc gctccgcagg aacttctcct cactcagccc atagtcacgg atcttcggcc 98677.doc -376 - 200533758 325 agcacttgcg ccagcagcgg atggg &lt;210〉 464 &lt;211&gt; 517 &lt;212&gt; DNA &lt;213&gt; 人類 &lt;220&gt; &lt;223&gt; Probe 595—at HG-U95Av2&Lt; 400 &gt; 462 tgcccatcta cagtaactgc ataatttgta ctctatattt ttaggaaaat tattcccttt tgtcccttgc catcaagatg catatgtaaa agattgttaa ttcacattaa cacaaaattt tgtgagcaag agagaactgg ataaaattat aataactagt tatttgctga tattcctata aagtcaaagt aggagttcct gccatagcaa gttgcttgga cagctgacct tagtttattg aaaacttgct tgatctgtat gattgcttaa ctattataat ttgtcatctt acaa gcctgaagaa atacaataac aatagcaaca ttaatgcatg tcttctattt &lt; 210> 463 &lt; 211 &gt; 325 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> φ &lt; 223> Probe 590-at HG-U95Av2 &lt; 400> 463 tccgtggcaa aggccacagc gcctggctgt cgaagatgtt tggtgtcggt tgagactctg cacattcaac gctggacttg ggagatctat gttgctgtcc cactatgaga agcacggctg atgtctcgcg gagcctgtgt ctgttcgtga ccttcgggaa acagagagga gtggcaacat cggacagcca catctgtcct ggcagcccct tggccaccgc ctttcacaaa gatggtcatc gctctgcttc gctccgcagg aacttctcct cactcagccc atagtcacgg atcttcggcc 98677.doc &376; &&&220; &lt;212; &lt; 212 &gt;> &gt;gt; aggcacttgcg ccagcalt &gt; 210 gt; Probe 595—at HG-U95Av2

&lt;400〉 464 aaagccagta tgtgctttgt cattttcccc ttgtgatcca gccccctaag cttcagtgtt atttccattc atttgcacat tttttctaaa accatgagta ggttgctgtc agagataaag taactctaca tttttcccag ttcatctaat ttaatgtgaa ttaattgtcc taaatgtaac tgaggaaatc atatttgctc gctgccattt cagcctttac acgaatcttt tctcttaaag aaaaagtaat ctaatagaaa ttttcacaag tctttctgtt tagaagaaaa tgggggtctg tcatactatt ataatttcct ttgatatctt tatttatact gccacctatt agtcaac gctggcttac aaaaaaaagg tacttatggc aggcacactt ttccaaagat aatattttgt tattataaaa ctttgttgga agtttctctg aggggaaatg ctgaaaatat tccccttaga accaaataaa gttgatcatt agtatttgaa tttcttcaag 60 120 180 240 300 360 420 480 517 &lt;210&gt; 465 &lt;211&gt; 588 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 626_s^at HG-U95Av2 98677.doc -377 - 200533758 &lt;4〇〇&gt; 465&Lt; 400> 464 aaagccagta tgtgctttgt cattttcccc ttgtgatcca gccccctaag cttcagtgtt atttccattc atttgcacat tttttctaaa accatgagta ggttgctgtc agagataaag taactctaca tttttcccag ttcatctaat ttaatgtgaa ttaattgtcc taaatgtaac tgaggaaatc atatttgctc gctgccattt cagcctttac acgaatcttt tctcttaaag aaaaagtaat ctaatagaaa ttttcacaag tctttctgtt tagaagaaaa tgggggtctg tcatactatt ataatttcct ttgatatctt tatttatact gccacctatt agtcaac gctggcttac aaaaaaaagg tacttatggc aggcacactt ttccaaagat aatattttgt tattataaaa ctttgttgga agtttctctg aggggaaatg ctgaaaatat tccccttaga accaaataaa gttgatcatt agtatttgaa tttcttcaag 60 120 180 240 300 300 360 420 480 517 &lt; 210 &gt; 465 &lt; 211 &gt; 588 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220> &lt_223_gt; Probe U95Av2 98677.doc -377-200533758 &lt; 4〇〇 &gt; 465

cgggctctgc tctgatcacc tttgatgacc ccaaagtggc tgagcaggtg ctgcaacaaa aggagcacac gatcaacatg gaggagtgcc ggctgcgggt gcaggtccag cccttggagc tgcccatggt caccaccatc caggtgtcca gccagttgag tggccggagg gtgttggtca ctggatttcc tgccagcctc aggctgagtg aggaggagct gctggacaag ctagagatct tctttggcaa gactaggaac ggaggtggcg atgtggacgt tcgggagcta ctgccaggga gtgtcatgct ggggtttgct agggatggag tggctcagcg tctgtgccaa atcggccagt tcacagtgcc actgggtggg cagcaagtcc ctctgagagt ctctccgtat gtgaatgggg agatccagaa ggctgagatc aggtcgcagc cagttccccg ctcggtactg gtgctcaaca ttcctgatat cttggatggc ccggagctgc atgacgtcct ggagatccac ttccagaagc ccacccgcgg gggcggggag gtagaggccc tgacagtcgt accccaag &lt;210〉 466 &lt;211&gt; 540 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 669」一at HG-U95Av2 &lt;400〉 466 gagaccagtg gcccagctgc gaccccagaa tatcaggtca ctggagaggg aagcataaca gggacttgga tctcgctgtc ccaatcccag caggagtcag actggctggc ggctggctct tgtctggctt tcctagggga gcactaagag tttcctctga acagaccagt aaaattgcac 98677.doc • 378 - 240 240cgggctctgc tctgatcacc tttgatgacc ccaaagtggc tgagcaggtg ctgcaacaaa aggagcacac gatcaacatg gaggagtgcc ggctgcgggt gcaggtccag cccttggagc tgcccatggt caccaccatc caggtgtcca gccagttgag tggccggagg gtgttggtca ctggatttcc tgccagcctc aggctgagtg aggaggagct gctggacaag ctagagatct tctttggcaa gactaggaac ggaggtggcg atgtggacgt tcgggagcta ctgccaggga gtgtcatgct ggggtttgct agggatggag tggctcagcg tctgtgccaa atcggccagt tcacagtgcc actgggtggg cagcaagtcc ctctgagagt ctctccgtat gtgaatgggg agatccagaa ggctgagatc aggtcgcagc cagttccccg ctcggtactg gtgctcaaca ttcctgatat cttggatggc ccggagctgc atgacgtcct ggagatccac ttccagaagc ccacccgcgg gggcggggag gtagaggccc tgacagtcgt accccaag &lt; 210> 466 &lt; 211 &gt; 540 &lt; 212 &gt; DNA &lt; 213〉 Human &lt; 220 &gt; &lt; 223 &lt; 223 &lt; 223 &lt; 223A gagaccagtg gcccagctgc gaccccagaa tatcaggtca ctggagaggg aagcataaca gggacttgga tctcgctgtc ccaatcccag caggagtcag actggctggc ggctggctct tgtctggctt tcctagggga gcactaagag tttcctcaga adoc.acac 240

200533758 taaatgaatc tcgttcccaa agaactaccc ccttttcagc tgagccctgg ggactgttcc aaagccagtg aaatgtgaag gaaagtgggg tccttcgggg cgatgctccc tcagcctcag aggagctcta ccctgctccc tgctttggct gaggggcttg ggaaaaaaac ttggcacttt ttcgtgtgga tcttgccaca tttctgatca gaggtgtaca ctaacatttc ccccgagctc ttggcctttg catttattta tacagtgcct tgctcggcgc ccaccacccc ctcaagcccc agcagccctc aacaggccca gggagggaag tgtgagcgcc ttggtatgac ttaaaattgg Φ &lt;210&gt; 467 &lt;211〉 415 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 717—at HG-U95Av2 &lt;400〉 467 gttcggattt gactgcctgt atatgttttg tgaaatggtc ctgtttttgg gtaggtgaca cgtggactct agtatgtaaa tgttacttga atctgtgctt cataatagtg tgtggcatgt atgtgcagac tcttggatgc tttatgcctg cgcaccagga gccctgtcct cacgttccca ggagggcggc ttcacccttc gtaaccagga gacaaggcgg ccatggattt gcccttgatt ctattttgct aatggaagat agaaaggaga gaaggttttt tttttttttt aacattctga agatggtgct gtgtcaagaa ggaccttttt tttcccctct cccctatttt ttaagtacct tggaggagga gaggttggtg acatgcatgg tggggatcta tggcctctgg tgctt &lt;210&gt; 468 300 360 420 480 540 60 120 180 240 300 360 98677.doc -379 - 415200533758 taaatgaatc tcgttcccaa agaactaccc ccttttcagc tgagccctgg ggactgttcc aaagccagtg aaatgtgaag gaaagtgggg tccttcgggg cgatgctccc tcagcctcag aggagctcta ccctgctccc tgctttggct gaggggcttg ggaaaaaaac ttggcacttt ttcgtgtgga tcttgccaca tttctgatca gaggtgtaca ctaacatttc ccccgagctc ttggcctttg catttattta tacagtgcct tgctcggcgc ccaccacccc ctcaagcccc agcagccctc aacaggccca gggagggaag tgtgagcgcc ttggtatgac ttaaaattgg Φ &lt; 210 &gt; 467 &lt; 211> 415 &lt; 212 &gt; DNA &lt; 213> human &lt; 220 &gt; &lt; 223> Probe 717-at HG-U95Av2 &lt; 400> 467 gttcggattt gactgcctgt atatgttttg tgaaatggtc ctgtttttgg gtaggtgaca cgtggactct agtatgtaaa tgttacttga atctgtgctt cataatagtg tgtggcatgt atgtgcagac tcttggatgc tttatgcctg cgcaccagga gccctgtcct cacgttccca ggagggcggc ttcacccttc gtaaccagga gacaaggcgg ccatggattt gcccttgatt ctattttgct aatggaagat agaaaggaga gaaggttttt tttttttttt aacattctga agatggtgct gtgtcacaaa ggaccttttt tttcccctct cccctatttt ttaagtacct tggaggagga ggggggggttttgtcat &gt; 468 300 360 420 480 540 60 120 180 240 300 360 98677.doc -379-415

200533758 &lt;211〉 475 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 823_at HG-U95Av2 &lt;400〉 468 acctgagggg cctcttatgg gctgggttct acccaggtgc taggaacact ccttcacaga tgggtgcttg gaggaaggaa acccagctct ggtccataga gagcaaaacg ctgtgctgcc ctgcccaccc tggcctctgc actcccctgc tgggtgtggc gcagcatatt caggaagctc agggccctgg ctcaggtggg gtcactctgg cagctcagag agggtgggag tgggtccaat gcactttgtt ctggctcttc caggctggga gagcctttca ggggtgggac accctgtgat ggggccctgc ctcctttgtg aggaagccgc tggggccagt tggtccccct tccatggact ttgttagttt ctccaagcag gacatggaca aggatgatct aggaagactt tggaaagagt aggaagactt tggaaagact tttccaaccc tcatcaccaa cgtctgtgcc atttt &lt;210〉 469 &lt;211〉 397 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 848_at HG-U95Av2 &lt;400&gt; 469 tccaggctcg tcattggagg tgaacaagca aacccagacg gctccactag gacttcaaat tgggggttgg atttgaagac ttttaagttt ccttccagcc cagaaagtct ctcattctag 60 120 180 240 300 360 420 475 60 9867Tdoc - 380 - 120 180200533758 cctcctggcc caggtgagtc ctagagctac aggggttctg gaaacattca ggagcttcct gtcctcccag ctcctcactc accttcagta acccccactg gactgacctg gtccacaggg cacctgccac cctgggcctg gcagctcagc ttcccaacac gcaggagcac acccagcccc cacatcctgt gcctccatca gctaaacacc acgtcacttc atgcaggtga aacccagtca ctgtgagctc ccaggtgcag ccagaggcac ctcaaga 240 300 360 397200533758 &lt; 211> 475 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 823_at HG-U95Av2 &lt; 400> 468 acctgagggg cctcttatgg gctgggttct acccaggtgc taggaacact ccttcacaga tgggtgcttg gaggaaggaa acccagctct ggtccataga gagcaaaacg ctgtgctgcc ctgcccaccc tggcctctgc actcccctgc tgggtgtggc gcagcatatt caggaagctc agggccctgg ctcaggtggg gtcactctgg cagctcagag agggtgggag tgggtccaat gcactttgtt ctggctcttc caggctggga gagcctttca ggggtgggac accctgtgat ggggccctgc ctcctttgtg aggaagccgc tggggccagt tggtccccct tccatggact ttgttagttt ctccaagcag gacatggaca aggatgatct aggaagactt tggaaagagt aggaagactt tggaaagact tttccaaccc tcatcaccaa cgtctgtgcc atttt &lt; 210> 469 &lt; 211> 397 &lt; 212> DNA &lt; 213 > human &lt; 220 &gt; &lt; 223 &gt; Probe 848_at HG-U95Av2 &lt; 400 &gt; 469 tccaggctcg tcattggagg tgaacaagca aacccagacg gctccactag gacttcaaat tgggggttgg atttgaagac ttttaagttt ccttccagcc cagaaagtct ctcattctag 60 120 180 240 300 360 420 475 60 9867Tdoc - 380 - 120 180200533758 cctcctggcc caggtgagtc ctagagctac aggggttctg gaaacattca ggagcttcct gtcctcccag ctcctcactc accttcagta acccccactg gactgacctg gtccacaggg cacctgccac cctgggcctg gcagctcagc ttcccaacac gcaggagcac acccagcccc cacatcctgt gcctccatca gctaaacacc acgtcacttc atgcaggtga aacccagtca ctgtgagctc ccaggtgcag ccagaggcac ctcaaga 240 300 360 397

&lt;210〉 470 &lt;211&gt; 101 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 &lt;223&gt; Probe 849_g_at HG-U95Av2 &lt;400〉 470 tttggtgctt tccagaatcc cgtaacacct gattaactga ggcatccact tctttcagca gactgatcag gacctccaag ccactgagca atgtataacc c 60 101&lt; 210〉 470 &lt; 211 &gt; 101 &lt; 212〉 DNA &lt; 213〉 human &lt; 220〉 &lt; 223 &gt; Probe 849_g_at HG-U95Av2 &lt; 400> 470 tttggtgctct tccagaatcc cgtaacacc gactactga ggcatccact tctttcagca gacct gacct 101

&lt;210&gt; 471 &lt;211&gt; 481 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 873_at HG-U95Av2 &lt;400〉 471 atagcgcctg tataagtaga tctgctttct gttcatctct ttgtcctgaa tggctttgtc ttgaaaaaaa atagatgttt taacttattt atatgaagca agctgtgtta cttgaagtaa 60 98677.doc -381 - 120 200533758 ctataacaaa aaaagaaaga gaaaaaaaaa aacacacaaa aagtccccct tcaatctcgt ttagtgccaa tgttgtgtgt tgcactcaag ttgtttaact gtgcatgtgc gtggaagtgt tcctgtctca atagctccaa gctgttaaag atatttttat tcaaactacc tatattcctt gtgtaattaa tgctgttgta gaggtgactt gatgagacac aacttgttcg acgtgtagtg actagtgact ctgtgatgaa aactgtgact ccaagcggtg tgtccctgcg tgcctttata ggaccctttg cacgaactct ggaagtggct cttataagcg cagcttcagt gatgtatgtt&lt; 210 &gt; 471 &lt; 211 &gt; 481 &lt; 212 &gt; DNA &lt; 213 &gt; humans &lt; 220〉 &lt; 223 &gt; Probe 873_at HG-U95Av2 &lt; 400> 471 atagcgcctg tataagtaga attgatgattatgatgattatgatga 60 98677.doc -381 - 120 200533758 ctataacaaa aaaagaaaga gaaaaaaaaa aacacacaaa aagtccccct tcaatctcgt ttagtgccaa tgttgtgtgt tgcactcaag ttgtttaact gtgcatgtgc gtggaagtgt tcctgtctca atagctccaa gctgttaaag atatttttat tcaaactacc tatattcctt gtgtaattaa tgctgttgta gaggtgactt gatgagacac aacttgttcg acgtgtagtg actagtgact ctgtgatgaa aactgtgact ccaagcggtg tgtccctgcg tgcctttata ggaccctttg cacgaactct ggaagtggct cttataagcg cagcttcagt gatgtatgtt

&lt;210〉 472 &lt;211〉 157 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 874—at HG-U95Av2 &lt;400〉 472 gagcagtttg ccctgggttc cctccttcca cctgcgttcc tcctctagct cccatggcag&lt; 210〉 472 &lt; 211〉 157 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 874-at HG-U95Av2 &lt; 400> 472 gagcagtttg ccctgggttc cctccttcca cctgcgttcc tcctctagct cccatggca

ccctttggtg cagaatgggc tgcacttcta gaccaaaact gcaaaggaac ttcatctaac tctgtcctcc ctccccacag cttacagacc attgtgg &lt;210&gt; 473 &lt;211&gt; 325 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; * &lt;223&gt; Probe 875—g—at HG-U95Av2 98677.doc -382- 60 200533758 &lt;400〉 473 tgggttcagg attccatgga ctcactccac aacccaagaa cttgtttatt ttattataat tgttaattct tatttaagtt ttagatacag agacttgggg tgttttgagg gtctttgcaa ccacctggac aagcaaaccc tctgcagcta acttattttt gaattttgtt tgttgatgtg attgatgttt taagtttatc aaattgcttt tcctcttgaa gaatc aaactccgaa gacttgaaca ccctagcttt ccccagacac aaacattatg ccttaagtaa tttcatggta ctagtgtttt ccacagttct acccctggga 120 180 240 300 325ccctttggtg cagaatgggc tgcacttcta gaccaaaact gcaaaggaac ttcatctaac tctgtcctcc ctccccacag cttacagacc attgtgg &lt; 210 &gt; 473 &lt; 211 &gt; 325 &lt; 212> DNA &lt; 213 &gt; human &lt; 2 95 &gt; 220 &gt; 220 &gt; doc -382- 60 200533758 &lt; 400> 473 tgggttcagg attccatgga ctcactccac aacccaagaa cttgtttatt ttattataat tgttaattct tatttaagtt ttagatacag agacttgggg tgttttgagg gtctttgcaa ccacctggac aagcaaaccc tctgcagcta acttattttt gaattttgtt tgttgatgtg attgatgttt taagtttatc aaattgcttt tcctcttgaa gaatc aaactccgaa gacttgaaca ccctagcttt ccccagacac aaacattatg ccttaagtaa tttcatggta ctagtgtttt ccacagttct acccctggga 120 180 240 300 325

&lt;210〉 474 &lt;211&gt; 547 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 925_at HG-U95Av2 &lt;4〇〇&gt; 474 gaggcctgcg tgttggatga acttgacatg gagctagcct tcctgaccat gtctggcatg gcatggaaga gtttgaggac atggagagaa gtctgccact atgcctgcag ctctacgccc cagggctgtc gccagaacta tcatggagtg tgcaatgggg gaccgcggca tgcagctcat gcacgccaac gcccagcgga cagatgctct ccagccaccg cacgagtatg tgccctgggt caccgtcaat gggaaaccct tggaagatca gacccagctc cttacccttg tctgccagtt gtaccagggc aagaagccgg atgtctgccc ttcctcaacc agctccctcc ggagtgtttg cttcgagtgt tggccggtgg gctgcggaga gctcatggaa ggcgagtggg aactcggctg 60 120 180 240 300 360 98677.doc - 383 - 420 480 480&lt; 210> 474 &lt; 211 &gt; 547 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 925_at HG-U95Av2 &lt; 4〇〇 &gt; 474 gaggcctgcg tgttggggatga acttgacatg gagctagcct tgtgggagagac gtctgccact atgcctgcag ctctacgccc cagggctgtc gccagaacta tcatggagtg tgcaatgggg gaccgcggca tgcagctcat gcacgccaac gcccagcgga cagatgctct ccagccaccg cacgagtatg tgccctgggt caccgtcaat gggaaaccct tggaagatca gacccagctc cttacccttg tctgccagtt gtaccagggc aagaagccgg atgtctgccc ttcctcaacc agctccctcc ggagtgtttg cttcgagtgt tggccggtgg gctgcggaga gctcatggaa ggcgagtggg aactcggctg 60 120 180 240 300 360 98677.doc - 383 - 420 480 480

200533758 cctgcctttt tttctgatcc agaccctcgg cacctgctac ttaccaactg gaaaatttta tgcatcccat gaagcccaga tacacaaaat tccaccccta gatcaagaat cctgctccac taagaat &lt;210&gt; 475 &lt;211&gt; 451 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 943_at HG-U95Av2 &lt;400〉 475 gacggtataa cacatctact gaaaaagcaa cgggaaatgt ggtcctattt aagccagccc ccacctaggg tctatttgtg tggcagttat tgggtttggt cacaaaacat cctgaaaatt cgtgcgtggg cttctttctc cctggtacaa acgtatggaa tgcttcttaa aggggaactg tcaagctggt gtcttcagcc agatgacatg agagaatatc ccagaaccct ctctccaagg tgtttctaga tagcacagga gagcaggcac tgcactgtcc acagtccacg gtacacagtc gg£tgggccg cctcccctct cctgggagca ttcgtcgtgc ccagcctgag cagggcagct ggactgctgc tgttcaggag ccaccagagc cttcctctct ttgtaccaca gtttcttctg taaatccagt gttacaatca gtgtgaatgg c &lt;210&gt; 476 &lt;211〉 469 &lt;212〉 DNA &lt;213&gt;人類 540 547 60 120 180 240 300 360 420 451 98677.doc - 384 - 60 60200533758 cctgcctttt tttctgatcc agaccctcgg cacctgctac ttaccaactg gaaaatttta tgcatcccat gaagcccaga tacacaaaat tccaccccta gatcaagaat cctgctccac taagaat &lt; 210 &lt; 212 &lt; 212 &lt; 212 &lt; 212 &lt; 212 &lt; 212 > 475 gacggtataa cacatctact gaaaaagcaa cgggaaatgt ggtcctattt aagccagccc ccacctaggg tctatttgtg tggcagttat tgggtttggt cacaaaacat cctgaaaatt cgtgcgtggg cttctttctc cctggtacaa acgtatggaa tgcttcttaa aggggaactg tcaagctggt gtcttcagcc agatgacatg agagaatatc ccagaaccct ctctccaagg tgtttctaga tagcacagga gagcaggcac tgcactgtcc acagtccacg gtacacagtc gg £ tgggccg cctcccctct cctgggagca ttcgtcgtgc ccagcctgag cagggcagct ggactgctgc tgttcaggag ccaccagagc cttcctctct ttgtaccaca gtttcttctg taaatccagt gttacaatca gtgtgaatgg c &lt; 210 &gt; 476 &lt; 211> 469 &lt; 212> DNA &lt; 213 &gt; human 540 547 60 120 180 240 300 360 420 451 98677.doc-384-60 60

200533758 &lt;220〉 &lt;223&gt; Probe 962^at HG-U95Av2 &lt;4〇〇&gt; 476 cttcccagct cttagaaatg tgctacgatg tctgtgaagg catggccttc ttggagagtc accaattcat acaccgggac ttggctgctc gtaactgctt ggtggacaga gatctctgtg tgaaagtatc tgactttgga atgacaaggt atgttcttga tgaccagtat gtcagttcag tcggaacaaa gtttccagtc aagtggtcag ctccagaggt gtttcattac ttcaaataca gcagcaagtc agacgtatgg gcatttggga tcctgatgtg ggaggtgttc agcctgggga agcagcccta tgacttgtat gacaactccc aggtggttct gaaggtctcc cagggccaca ggctttaccg gccccacctg gcatcggaca ccatctacca gatcatgtac agctgctggc acgagcttcc agaaaagcgt cccacatttc agcaactcct gtcttccat &lt;210&gt; 477 &lt;211&gt; 265 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 1529_at HG-U95Av2 120 180 240 300 360 420 469 &lt;400〉 477 aattactgta ttctgaaagc cttggctgct gtgttaattt tctaaaagga cctggatctc ttttactaga taattaactt gctgctatga tttgcaccaa aggttgcttt tgccgttttg agtacctttc aaatggtcca tatgagcata tagagaaaac ttatgttgct gatagactct tttatactgc tattcacaag aggctactgt ttttaaggat tgaaggatga ataaattcca 60 120 180 240 9S677.doc - 385 - 200533758 265 agtcttttca cctgtcaggc atgca &lt;210〉 478 &lt;211&gt; 606 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 31849_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature • &lt;222〉 （305)..(319) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221〉 misc一feature &lt;222〉 （389)..(415) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 478 aaattcacag tactccattt tggggtccaa actgtaatgc tcaaaataat aaatgcttac200533758 &lt; 220> &lt; 223 &gt; Probe 962 ^ at HG-U95Av2 &lt; 4〇〇 &gt; 476 cttcccagct cttagaaatg tgctacgatg tctgtgaagg catggccttc ttggagagtc accaattcat acaccgggac ttggctgctc gtaactgctt ggtggacaga gatctctgtg tgaaagtatc tgactttgga atgacaaggt atgttcttga tgaccagtat gtcagttcag tcggaacaaa gtttccagtc aagtggtcag ctccagaggt gtttcattac ttcaaataca gcagcaagtc agacgtatgg gcatttggga tcctgatgtg ggaggtgttc agcctgggga agcagcccta tgacttgtat gacaactccc aggtggttct gaaggtctcc cagggccaca ggctttaccg gccccacctg gcatcggaca ccatctacca gatcatgtac agctgctggc acgagcttcc agaaaagcgt cccacatttc agcaactcct gtcttccat &lt; 210 &gt; 477 &lt; 211 &gt; 265 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 1529_at HG-U95Av2 120 180 240 300 360 420 469 &lt; 400> 477 aattactgta ttctgaaagc cttggctgct gtgttaattt tctaaaagga cctggatctc ttttactaga taattaactt gctgctatga tttgcaccaa aggttgcttt tgccgttttg agtacctttc aaatggtcca tatgagcata tagagaaaac ttatgttgct gatagactct tttatactgc tattcacaag aggctactgt ttttaaggat tgaaggatg a ataaattcca 60 120 180 240 9S677.doc-385-200533758 265 agtcttttca cctgtcaggc atgca &lt; 210〉 478 &lt; 211 &gt; 606 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 31849_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature • &lt; 222〉 (305) .. (319) &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221〉 misc-feature &lt; 222〉 (389) .. (415) &lt; 223 &gt; n is a, g, c or t &lt; 400> 478 aaattcacag tactccattt tggggtccaa actgtaatgc tcaaaataat aaatgcttac

60 120 180 240 300 360 acgaaaatta tttattgaga atattcatat aaaaattacc taaagcaaag taaaaaaagt aaaatcaagg tggtatattt gaagtgaatg gtgattggaa atttttagct gtaacaaaaa gaaagaaaac aacttttttt aaagcctcat tctcttttct ttcaaaatgt accttattcc cacacactct tgggctgacc tttattttat caataagctc aatattactt tgtttaaaat aagannnnnn nnnnnnnnnc attctctctt taaccatata atttaaaaac tcctcttcac gattgat age aaaatcagaa acgttaggnn nnnnnnnnnn nnnnnnnnnn nnnnntaagt 98677.doc -386 - 420 200533758 tggaaaaact tccataattt tcacccctct gtggta attattaata cattttaatt ccctatcatt atattatcct aattatagga aactatcaaa atccatccat aagaagaaaa taaataaata atctattgaa gataataccc aaagcaatct attgtacagg atttgttcta gatttccaac 480 540 600 60660 120 180 240 300 360 acgaaaatta tttattgaga atattcatat aaaaattacc taaagcaaag taaaaaaagt aaaatcaagg tggtatattt gaagtgaatg gtgattggaa atttttagct gtaacaaaaa gaaagaaaac aacttttttt aaagcctcat tctcttttct ttcaaaatgt accttattcc cacacactct tgggctgacc tttattttat caataagctc aatattactt tgtttaaaat aagannnnnn nnnnnnnnnc attctctctt taaccatata atttaaaaac tcctcttcac gattgat age aaaatcagaa acgttaggnn nnnnnnnnnn nnnnnnnnnn nnnnntaagt 98677.doc -386 - 420 200533758 tggaaaaact tccataattt tcacccctct gtggta attattaata cattttaatt ccctatcatt atattatcct aattatagga aactatcaaa atccatccat aagaagaaaa taaataaata atctattgaa gataataccc aaagcaatct attgtacagg atttgtccta 480t540

&lt;210&gt; 479 &lt;211〉 371 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 32110^at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 38, 41， 50, 60, 65, 74， 104， 127 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 479 atgatctgcc agagcctctc caggggtgga atacatgncc nggactaagn ccaatgacan ccttnccatc tttnccagct atggtgactg ggttaggtat gatncttgtg agttaagaca atgaagncca gagggaattt caagacttat gggaatgctg ggtagaagct gttttaattc ccctgttgaa tgtgaaaaag gtagtagtat tcctgggtct ttatgatgac caccttgggc cttgggatca tgaccaggaa tcacgtgaag ctgacaccac tgaagggaga gttgagaggc agaaagagat caagtccttg gtgaaattgt ttaagtacag gatcaagcct tgcttgagat tggccttacc t 60 120 180 240 300 360 98677.doc -387 - 371 200533758 &lt;210〉 480 &lt;211〉 396 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 32385一at HG-U95Av2 &lt;400〉 480 60 120 180 240 300 360 396&lt; 210 &gt; 479 &lt; 211〉 371 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 32110 ^ at HG-U95Av2 &lt; 220> &lt; 221〉 misc_feature &lt; 222〉 38, 41, 50, 60, 65, 74, 104, 127 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 479 atgatctgcc agagcctctc caggggtgga atacatgncc nggactaagn ccaatgacangagagagacgagacgagatgatcat ggtgtatat ggtgtatat tgtgaaaaag gtagtagtat tcctgggtct ttatgatgac caccttgggc cttgggatca tgaccaggaa tcacgtgaag ctgacaccac tgaagggaga gttgagaggc agaaagagat caagtccttg gtgaaattgt ttaagtacag gatcaagcct tgcttgagat tggccttacc t 60 120 180 240 300 360 98677.doc -387 - 371 200533758 &lt; 210> 480 &lt; 211> 396 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223〉 Probe 32385-at HG-U95Av2 &lt; 400> 480 60 120 180 240 300 360 396

gtcatcttgt aattctatgt gtaactttgg aggaatttcc aaactgtttt ctgcaatggc tgcaccattt tacattcctg tcagcaatgt acaggattcc agtttctcca tatccctgcc aacacttggt attttccttt ttttcagtta gttactctag tgggtatgtg gtggttgtcc cattgctgtt tgttttgatt ttcattgtcc ctaatgacta atgatattga gcatctaata tccagttgtc ccagcaacat ttgtttgaag agactattct ttcctgtgta aatggtcttg gcatctttgt tgaaaatcga ttggcagcca ggtgcagtag ctcacacctg taatcccagc actttgggag gctgcgctgg gcagatcgct taagct &lt;210&gt; 481 &lt;211&gt; 532 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 32791—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 127..169， 233..248, 471， 472， 476， 495..498, 500， 502， 504， 507 &lt;223&gt; n 為 a，g，c 或 t 98677.doc - 388 - 200533758 &lt;400&gt; 481gtcatcttgt aattctatgt gtaactttgg aggaatttcc aaactgtttt ctgcaatggc tgcaccattt tacattcctg tcagcaatgt acaggattcc agtttctcca tatccctgcc aacacttggt attttccttt ttttcagtta gttactctag tgggtatgtg gtggttgtcc cattgctgtt tgttttgatt ttcattgtcc ctaatgacta atgatattga gcatctaata tccagttgtc ccagcaacat ttgtttgaag agactattct ttcctgtgta aatggtcttg gcatctttgt tgaaaatcga ttggcagcca ggtgcagtag ctcacacctg taatcccagc actttgggag gctgcgctgg gcagatcgct taagct &lt; 210 &gt; 481 &lt; 211 &gt; 532 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 32791-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> 127..169, 233..248, 471, 472, 476, 495..498, 500, 502, 504, 507 &lt; 223 &gt; n is a, g, c or t 98677.doc-388-200533758 &lt; 400 &gt; 481

ttgtaaacag atcatcctag gcgaaagttt tttttgtttg tttgctttta aattagttta tttctaaatc ttagtcttcc acatttctag aggccacctg acacaagtcc ctgtatctga agtctannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna gtggataact taatctttta atacagttcc gtcattccca tcttgttttc agaagagaag gtnnnnnnnn nnnnnnnnaa catatccact gtgtgcatag agggtctctt cacgttgatg cttggcattc catcagcttt ctctaagtct ttgctcaagt tcaaccttaa aatgatgtta gacaacaggt cccagtcagt tccctctatt ttcacccatt ttgctcacaa gccatattgg cccgattagt ggtactgtct gactcacgtg tgtgatccaa ataaaggtag ctgctgacca nnaaanaaaa aaaaaaaaaa aaaannnnan ananaancca gggttctctc atgaggagtt aa &lt;210〉 482 &lt;211&gt; 545 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 33325—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 32..58, 231， 242, 277, 451..470 &lt;223〉n 為 a，g，c 或 t &lt;400〉 482 catcccaaag tcaaacatgg gcaagaggtg annnnnnnnn nnnnnnnnnn nnnnnnnntt 98677.doc - 389- 120 120ttgtaaacag atcatcctag gcgaaagttt tttttgtttg tttgctttta aattagttta tttctaaatc ttagtcttcc acatttctag aggccacctg acacaagtcc ctgtatctga agtctannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna gtggataact taatctttta atacagttcc gtcattccca tcttgttttc agaagagaag gtnnnnnnnn nnnnnnnnaa catatccact gtgtgcatag agggtctctt cacgttgatg cttggcattc catcagcttt ctctaagtct ttgctcaagt tcaaccttaa aatgatgtta gacaacaggt cccagtcagt tccctctatt ttcacccatt ttgctcacaa gccatattgg cccgattagt ggtactgtct gactcacgtg tgtgatccaa ataaaggtag ctgctgacca nnaaanaaaa aaaaaaaaaa aaaannnnan ananaancca gggttctctc atgaggagtt aa &lt; 210〉 482 &lt; 211 &gt; 545 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 33325-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222〉 32..58, 231, 242, 277, 451..470 &lt; 223〉 n is a, g, c or t &400; 482 catcccaaag tcaaacatgg gcaagaggtg annnnnnnnn nnnnnnnnnn nnnnnnnntt 98677.doc-389- 120 120

200533758 tgtctgtgat tttaaactaa ctgtgtatgt attgatgttt ggaagattgt ttgaatttta aagtgataat agtacttaat gttatccagt attgttcatt aaatggtgtt atcctaaagc tgcacttggg atttttacct aacgctttac tgattctctc aagcacatgg ncaaagtttg antttgcact ccgttcattt ctgacacgtt ttgctgncct cctacctttc taagcgtcat gcaaattcga gaatggagaa ggacgctgcc ggtccctgag cggtgtggag agggcggaag gtggactcca gcgcagcttg aggggctgag gacggaggct gcagcatctg tgtcgttcta ctgagcacgc ttctctgcct cgctcctgac nnnnnnnnnn nnnnnnnnnn tcagcagtta tgtttacaca tcatttttat gttcctgctt tgtaattcat gtttgagatg ggtggccact gtaca &lt;210&gt; 483 &lt;211〉 469 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 33924—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （81)..(113) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （378)..(401) &lt;223〉n 為 a，g，c 或 t 180 240 300 360 420 480 540 545 98677.doc - 390 - 60 200533758 &lt;400〉 483200533758 tgtctgtgat tttaaactaa ctgtgtatgt attgatgttt ggaagattgt ttgaatttta aagtgataat agtacttaat gttatccagt attgttcatt aaatggtgtt atcctaaagc tgcacttggg atttttacct aacgctttac tgattctctc aagcacatgg ncaaagtttg antttgcact ccgttcattt ctgacacgtt ttgctgncct cctacctttc taagcgtcat gcaaattcga gaatggagaa ggacgctgcc ggtccctgag cggtgtggag agggcggaag gtggactcca gcgcagcttg aggggctgag gacggaggct gcagcatctg tgtcgttcta ctgagcacgc ttctctgcct cgctcctgac nnnnnnnnnn nnnnnnnnnn tcagcagtta tgtttacaca tcatttttat gttcctgctt tgtaattcat gtttgagatg ggtggccact gtaca &lt; 210 &gt; 483 &lt; 211〉 469 &lt; 212〉 DNA &lt; 213〉 human &lt; 220 &gt; &lt; 223〉 Probe 33924-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (81 ) .. (113) &lt; 223> n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (378) .. (401) &lt; 223> n is a, g, c or t 180 240 300 360 420 480 540 545 98677.doc-390-60 200533758 &lt; 400〉 483

120 180 240 300 360 420 469 gtcgcattaa tgaggccctt ccacatcatt tttaaactaa tgtttttcta tattaacatt attatggata tttggctttc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnncccatgc tccaatcaaa gggattttta gtagtgcctc taagcaagca ccgatgagtc agtcccacgt attttctttt ttgtcagtat tgtttgggaa ggagacatgc cgggatgtgt catcgtgcca aataccacat ttcctgttgg cacagtttca cagaagtaaa cataagcatg ttttaacagg tttttctttt cttttttctt ttttaaaatg ttttatttat ttaacccgcc attgtgtgtt tttaagtatt ttcttttnnn nnnnnnnnnn nnnnnnnnnn ncaatctaac tggctatgtt attattatta aatttatgtt ttgcaactta gaaaccagct acagtatgg &lt;210〉 484 &lt;211&gt; 477 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223〉 Probe 34176一at HG-U95Av2 &lt;220〉 &lt;221〉mi sc一feature &lt;222〉 53, 200, 225, 245, 268, 397..411 &lt;223&gt; n 為 a，g，c 或 t &lt;4〇〇&gt; 484 60 ggagcttatt cctggctcca tcgctaacac gttgactgct tattatggga aanttttctc tgaagccagg gagaagcatt gattgatgtg ggcaaatcca agctccagcc aggtcgcagt 98677.doc -391 - 120 200533758 cccaaatgcc gacatcactg actccaggga ccagggacat ggagaaagct gtttatgata tctttaacca ggccctcttn actagagctg gtgtttgtga ctggnccaac aagatgtggc tatgnccagg ggacatctga gtatgtgncc cagtcatctt ttttcacagg ttgaagggag agaaaagatt ttgagttaag gtcattggct gctctactct gtcccctacc tggtcaccta gtgatagccc cagtggagat actgtccata caaggtnnnn nnnnnnnnnn nataccacag taaaaggcca ggccaggagg ggtaggagac tatggagatc ttacctcctg ataaatg ® &lt;210&gt; 485 &lt;211〉 440 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 34303_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 43, 44, 49, 50, 53, 54, 56..59, 61, 64..66 &lt;223&gt; n 為 a, g, c 或 t120 180 240 300 360 420 469 gtcgcattaa tgaggccctt ccacatcatt tttaaactaa tgtttttcta tattaacatt attatggata tttggctttc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnncccatgc tccaatcaaa gggattttta gtagtgcctc taagcaagca ccgatgagtc agtcccacgt attttctttt ttgtcagtat tgtttgggaa ggagacatgc cgggatgtgt catcgtgcca aataccacat ttcctgttgg cacagtttca cagaagtaaa cataagcatg ttttaacagg tttttctttt cttttttctt ttttaaaatg ttttatttat ttaacccgcc attgtgtgtt tttaagtatt ttcttttnnn nnnnnnnnnn nnnnnnnnnn ncaatctaac tggctatgtt attattatta aatttatgtt ttgcaactta gaaaccagct acagtatgg &lt; 210〉 484 &lt; 211 &gt; 477 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223〉 Probe 34176-at HG-U95Av2 &lt; 220〉 &lt; 221〉 mi sc-1 feature &lt; 222〉 53, 200, 225, 245, 268, 397..411 &lt; 223 &gt; n is a, g, c or t &lt; 4〇〇 &gt; 484 60 ggagcttatt cctggctcca tcgctaacac gttgactgct tattatggga aanttttctc tgaagcgatt ggt ggcaaatcca agctccagcc aggtcgcagt 98677.doc -391-120 200533758 cccaaatgcc gacatcactg actccaggga ccagggac at ggagaaagct gtttatgata tctttaacca ggccctcttn actagagctg gtgtttgtga ctggnccaac aagatgtggc tatgnccagg ggacatctga gtatgtgncc cagtcatctt ttttcacagg ttgaagggag agaaaagatt ttgagttaag gtcattggct gctctactct gtcccctacc tggtcaccta gtgatagccc cagtggagat actgtccata caaggtnnnn nnnnnnnnnn nataccacag taaaaggcca ggccaggagg ggtaggagac tatggagatc ttacctcctg ataaatg ® &lt; 210 &gt; 485 &lt; 211> 440 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 34303_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 43, 44, 49, 50, 53, 54, 56..59, 61, 64 ..66 &lt; 223 &gt; n is a, g, c or t

&lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 68..182, 192, 311..334 &lt;223&gt; n 為 a，g, c 或 t &lt;400&gt; 485 aatgtcaacc ggagccctta caccagccct ccagcatcta atnnacttnn aanntnnnnt naannnannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 98677.doc - 392 - 200533758 nntggcagcg gncttatcct tctctgttgc caaccttgcc gtccgacctc ctccgccccc 240 atgcggtgac cccgtccgtg tctgtgtctg tccatacgtg tgagtccagc taaaaagaca 300 aaacagaacc nnnnnnnnnn nnnnnnnnnn nnnntggaga aggctccgac gtctccgaag 360 tgcagccctt gggatggcat tccgttgtgt gccttattcc tggagaatct gtatacggct 420 cgcctataga aatatagcct 440 &lt;210〉 486 &lt;211〉 521 &lt;212&gt; DNA &lt;213&gt; 人類&lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 68..182, 192, 311..334 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 485 aatgtcaacc ggagccctta caccagccct ccagcatcta atnnnnnnnnn anannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 98677.doc - 392 - 200533758 nntggcagcg gncttatcct tctctgttgc caaccttgcc gtccgacctc ctccgccccc 240 atgcggtgac cccgtccgtg tctgtgtctg tccatacgtg tgagtccagc taaaaagaca 300 aaacagaacc nnnnnnnnnn nnnnnnnnnn nnnntggaga aggctccgac gtctccgaag 360 tgcagccctt gggatggcat tccgttgtgt gccttattcc tggagaatct gtatacggct 420 cgcctataga aatatagcct 440 &lt; 210〉 486 &lt; 211〉 521 &lt; 212 &gt; DNA &lt; 213 &gt; human

&lt;220&gt; &lt;223&gt; Probe 34678^at HG-U95Av2 &lt;220&gt; &lt;221〉mi sc一feature &lt;222&gt; 158, 161..164, 166..171, 173..177, 179..186, 188..191, 193..198 &lt;223〉n 為 a，g，c 或 t • &lt;220〉 &lt;221〉 misc一feature &lt;222&gt; 200..214, 218..234, 432..454, 457..491 &lt;223〉n 為 a，g，c 或 t &lt;400〉 486 ccgaactatt tgtcaatgaa gattgtaaag ccaaatgtgt aacaaaggca aaggcttcat 60 ttcaagagtc atccagcaat gagagaatcc tgcctctgta gaccaacatc cagtgtgatt 120 ttgtgtctga gaccacaccc cagtagcagg ttacgccntg nnnncnnnnn ncnnnnntnn 180 98677.doc - 393 - 200533758 nnnnnngnnn ntnnnnnncn nnnnnnnnnn nnnnaacnnn nnnnnnnnnn nnnntgttat ctcttaagta ttaaaagttt tattttctaa agtttaaatc atgtttttca aaatattttt caaggtggct ggttccattt aaaaatcatc tttttatatg tgtcttcggt tctagacttc agcttttgga aattgctaaa tagaattcaa aaatctctgc atcctgaggt gatatacttc atatttgtaa tnnnnnnnnn nnnnnnnnnn nnnnaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngcccacaac cattgctata ttttgtatgg a ® &lt;210&gt; 487 &lt;211&gt; 485 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 3480(Lat HG-U95Av2 &lt;220&gt; &lt;221&gt; misc-feature &lt;222&gt; 344..347, 349, 351..353, 416..435 &lt;223&gt; n 為 a，g，c 或 t&lt; 220 &gt; &lt; 223 &gt; Probe 34678 ^ at HG-U95Av2 &lt; 220 &gt; &lt; 221〉 mi sc-feature &lt; 222 &gt; 158, 161..164, 166..171, 173..177, 179. .186, 188..191, 193..198 &lt; 223〉 n is a, g, c or t • &lt; 220〉 &lt; 221〉 misc-feature &lt; 222 &gt; 200..214, 218..234 , 432..454, 457..491 &lt; 223〉 n is a, g, c or t &lt; 400〉 486 ccgaactatt tgtcaatgaa gattgtaaag ccaaatgtgt aacaaaggca aaggcttcat 60 ttcaagagtc 180ccnnga nncgtcnncgtcnncgtcnccacccccccacc .doc - 393 - 200533758 nnnnnngnnn ntnnnnnncn nnnnnnnnnn nnnnaacnnn nnnnnnnnnn nnnntgttat ctcttaagta ttaaaagttt tattttctaa agtttaaatc atgtttttca aaatattttt caaggtggct ggttccattt aaaaatcatc tttttatatg tgtcttcggt tctagacttc agcttttgga aattgctaaa tagaattcaa aaatctctgc atcctgaggt gatatacttc atatttgtaa tnnnnnnnnn nnnnnnnnnn nnnnaannnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngcccacaac cattgctata ttttgtatgg a ® &lt; 210 &gt; 487 &lt; 211 &gt; 485 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 3480 (Lat HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222 &gt; 344..347, 349, 351..353, 416..435 &lt; 223 &gt; n is a, g, c or t

&lt;400&gt; 487 tggccaaaag ctgaagggag ttactgagaa aatagttaac aattactgtc aggtgtcatc actgttcaaa aggtaagcac atttagaatt ttgttcttga cagttaactg actaatctta cttccacaaa atatgtgaat ttgctgcttc tgagaggcaa tgtgaaagag ggagtattac ttttatgtac aaagttattt atttatagaa attttggtac agtgtacatt gaaaaccatg taaaatattg aagtgtctaa caaatggcat tgaagtgtct ttaataaagg ttcatttata 98677.doc -394 - 200533758 aatgtcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaannnngnc nnnaattatc 360 tttcccccaa aaaagaaaaa aaaaataggc gaagcaaaat cacatactgt ttgttnnnnn 420 nnnnnnnnnn nnnnntgcta gattcctgac attttgtttt gaatttttct acacctggag 480 cttgt 485&Lt; 400 &gt; 487 tggccaaaag ctgaagggag ttactgagaa aatagttaac aattactgtc aggtgtcatc actgttcaaa aggtaagcac atttagaatt ttgttcttga cagttaactg actaatctta cttccacaaa atatgtgaat ttgctgcttc tgagaggcaa tgtgaaagag ggagtattac ttttatgtac aaagttattt atttatagaa attttggtac agtgtacatt gaaaaccatg taaaatattg aagtgtctaa caaatggcat tgaagtgtct ttaataaagg ttcatttata 98677.doc -394 - 200533758 aatgtcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaannnngnc nnnaattatc 360 tttcccccaa aaaagaaaaa aaaaataggc gaagcaaaat cacatactgt ttgttnnnnn 420 nnnnnnnnnn nnnnntgcta gattcctgac attttgtttt gaatttttct acacctggag 480 cttgt 485

&lt;210〉 488 &lt;211&gt; 511 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 34857—at HG-U95Av2 &lt;400〉 488 gaaagctttc ccaattgcac ttgcatctaa acaaaactgt tgcagttttt actctattta 60 ttttgttccc catgtttatg aaagtcctgc acagtttcaa aggcatggta aataatatat 120 caatgtttat gtagtctgtt acagaaacag ctatagataa cattatccag tgaagagcaa 180 aattcaagct ttagaaaata ttcatgcatg caattttgac atatctaaaa ataggttttt 240 gtatatttat ggtgggaggt ggttgggaac ttttaacaaa atggggtgtt aatttttgta 300 cagtctgtgg gcatttacac atttttaatg tattaaaatt tggtaattat gtgtacatta 360 aattaataaa agttacttct agttatgatt tgtgaattcc ctaagacctt ggattttttt 420 aagtaacttt atatcagaaa tgatactgca tctttatatt tttaaaattg tattgctgct 480 caagaatggt accctcttgt caaaaaggca t 511 &lt;210&gt; 489 98677.doc -395 - 200533758 &lt;211&gt; 361 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 35484—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 157..180， 182， 183, 232, 234, 235, 237, 239..242 &lt;223&gt; n 為 a，g，c 或 t&lt; 210> 488 &lt; 211 &gt; 511 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223〉 Probe 34857--at HG-U95Av2 &lt; 400> 488 gaaagctttc ccaattgcac ttgcatctaa acaaaactgt tgcagttttt catcttttcc acaaaactgt tgcagttttt catctttttac cc acagtttcaa aggcatggta aataatatat 120 caatgtttat gtagtctgtt acagaaacag ctatagataa cattatccag tgaagagcaa 180 aattcaagct ttagaaaata ttcatgcatg caattttgac atatctaaaa ataggttttt 240 gtatatttat ggtgggaggt ggttgggaac ttttaacaaa atggggtgtt aatttttgta 300 cagtctgtgg gcatttacac atttttaatg tattaaaatt tggtaattat gtgtacatta 360 aattaataaa agttacttct agttatgatt tgtgaattcc ctaagacctt ggattttttt 420 aagtaacttt atatcagaaa tgatactgca tctttatatt tttaaaattg tattgctgct 480 caagaatggt accctcttgt caaaaaggca t 511 &lt; 210 &gt; 489 98677.doc -395-200533758 &lt; 211 &gt; 361 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223〉 Probe 35484-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222〉 157..180, 182, 183, 232, 234, 235, 237, 239..242 &lt; 223 &gt; n is a, g, c t

&lt;220〉 &lt;221&gt; misc.feature &lt;222&gt; 245..249, 251..258 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 489 60 120 180 240 300 360 361 acactgtttt gtaatgatcg ctttgcatgt cttttccagc tgactccgcc accatctcct gcctggatga ctgcagcagc atccttgctg gcctctctgc ttcctgcatt gcctcctctg aatcttcagg atgccaagtt tgtggaggaa cggagannnn nnnnnnnnnn nnnnnnnnnn anngtcatga acaaagtcat ccagatggtc cccgagttcg ctgccagccc cnannangnn nnccnnnnnc nnnnnnnngc ccttcttcgt gatgggatta caggtcggaa tgtacggatt gtttcatttt ggggtaatga tggatcagcc acagccaagc cttacccgtg ctgacgaatc &lt;210〉 490 &lt;211&gt; 505 &lt;212&gt; DNA &lt;213&gt;人類 98677.doc - 396 -&lt; 220> &lt; 221 &gt; misc.feature &lt; 222 &gt; 245..249, 251..258 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 489 60 120 180 240 300 360 361 acactgtttt gtaatgatcg ctttgcatgt cttttccagc tgactccgcc accatctcct gcctggatga ctgcagcagc atccttgctg gcctctctgc ttcctgcatt gcctcctctg aatcttcagg atgccaagtt tgtggaggaa cggagannnn nnnnnnnnnn nnnnnnnnnn anngtcatga acaaagtcat ccagatggtc cccgagttcg ctgccagccc cnannangnn nnccnnnnnc nnnnnnnngc ccttcttcgt gatgggatta caggtcggaa tgtacggatt gtttcatttt ggggtaatga tggatcagcc acagccaagc cttacccgtg ctgacgaatc &lt; 210> 490 &lt; 211 &gt; 505 &lt; 212 &gt; DNA &lt; 213 &gt; human 98677.doc-396-

200533758 &lt;220〉 &lt;223&gt; Probe 35763_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc一feature &lt;222&gt; 214..228, 315, 336..369, 455..469, 479, 480 &lt;223&gt; n 為 a，g, c 或 t &lt;400〉 490 ttgcccatga aggtggccat ccgcagcgtg gccgtgacca aggagcgcag ccacgtgctg gtgggcctgg aggatggcaa gctcatcgtg gtggtcgcgg ggcagccctc tgaggtgcgc agcagccagt tcgcgcggaa gctgtggcgg tcctcgcggc gcatctccca ggtgtcctcg ggagagacgg aatacaaccc tactgaggcg cgcnnnnnnn nnnnnnnncg gctgctcggg ccccgccccc ggcaggcctg gcccgggagg ccccgcccag aagtcggcgg gaacaccccg gggtgggcag cccanggggg tgagcggggc ccaccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc cctcagggat tggcgggcgg aagtcccgcc cctcgccggc tgaggggccg ccctgagggc cagcactggc gtctgcggcc gctgnnnnnn nnnnnnnnna gtctggggnn gggttccccg gcttccaagt cgctg &lt;210〉 491 &lt;211&gt; 136 &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223〉 Probe 35861—at HG-U95Av2 60 120 180 240 300 360 420 480 505 986~7.doc - 397- 60 200533758 &lt;400〉 491 gatgctgccc ttctttgcac gaaagcctgg ccctcttgct ttggcgtgat aaacccctgt ccatcttccc caaagctcat ttatgagccc acccagaggc tcctaccccc aaagattttc acagaaactt gaggcc 120 136 &lt;210&gt; 492 &lt;211&gt; 541 &lt;212〉 DNA &lt;213&gt; 人類200533758 &lt; 220> &lt; 223 &gt; Probe 35763_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222 &gt; 214..228, 315, 336..369, 455..469, 479, 480 &lt; 223 &gt; n is a, g, c or t &lt; 400> 490 ttgcccatga aggtggccat ccgcagcgtg gccgtgacca aggagcgcag ccacgtgctg gtgggcctgg aggatggcaa gctcatcgtg gtggtcgcgg ggcagccctc tgaggtgcgc agcagccagt tcgcgcggaa gctgtggcgg tcctcgcggc gcatctccca ggtgtcctcg ggagagacgg aatacaaccc tactgaggcg cgcnnnnnnn nnnnnnnncg gctgctcggg ccccgccccc ggcaggcctg gcccgggagg ccccgcccag aagtcggcgg gaacaccccg gggtgggcag cccanggggg tgagcggggc ccaccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc cctcagggat tggcgggcgg aagtcccgcc cctcgccggc tgaggggccg ccctgagggc cagcactggc gtctgcggcc gctgnnnnnn nnnnnnnnna gtctggggnn gggttccccg gcttccaagt cgctg &lt; 210> 491 &lt; 211 &gt; 136 &lt; 212 &gt; DNA &lt; 213> human &lt; 220 &gt; &lt; 223> Probe 35861-at HG-U95Av2 60 120 180 240 300 360 420 480 505 986 ~ 7.doc-397- 60 200533758 &lt; 400〉 491 gatgctgccc ttctttgcac gaaagcctgg ccctcttgct ttggc gtgat aaacccctgt ccatcttccc caaagctcat ttatgagccc acccagaggc tcctaccccc aaagattttc acagaaactt gaggcc 120 136 &lt; 210 &gt; 492 &lt; 211 &gt; 541 &lt; 212> DNA &lt; 213 &gt; human

&lt;220&gt; &lt;223&gt; Probe 35959^at HG-U95Av2 &lt;220〉 &lt;221〉 misc_feature &lt;222〉 （313)..(313) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （332)..(332) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （357)..(357) &lt;223〉 n 為 a，g，c 或 t &lt;400〉 492 60 120 gatcttcaga aagtaccata atgtcatcct actctacatt tcacaagacg aattattttg agatttgttt attatattaa aatgtttttt tacgttccca ctaaattttg accccatata 98677.doc -3.)S - 180 180&lt; 220 &gt; &lt; 223 &gt; Probe 35959 ^ at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc_feature &lt; 222> (313) .. (313) &lt; 223 &gt; n is a, g, c or t &lt; 220> &lt; 221 &gt; misc_feature &lt; 222> (332) .. (332) &lt; 223〉 n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (357). . (357) &lt; 223〉 n is a, g, c or t &lt; 400〉 492 60 120 gatcttcaga aagtaccata atgtcatcct actctacatt tcacaagacg aattattttg agatttgttt attatattaa aatgtttttt tacgttccca ctaaattttg accccatata 98677.doc -3

200533758 aagaaatgtg ttatgtatgt tgtgcctcct tagagacata aatttagtgt caaaacatgg gagatggctt actcagaagc atactccact taacatacca tggcctgagc taagtaccat gtcctgtttg tgtcttattt ttaaatattt tctttgtcca catgggccgt tgaccttaga gttaaggcgg ttngcttttt tgaagaaatc anccaaagtt tctgggaaac tatgttncaa ggttgaaatg gagagtagat ttaattttat ttgtcttgta gggaagaaat cttcctttga accgcttttc ttgctttttc cctttttccc aaactaggtt acaggttctt atctgcaagg ttcaagttgc ttagacattg ttttccagta ttctgcaggg ccagtcagtt gtacagaagt &lt;210〉 493 &lt;211&gt; 500 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 36014—at HG-U95Av2 240 300 360 420 480 540 541200533758 aagaaatgtg ttatgtatgt tgtgcctcct tagagacata aatttagtgt caaaacatgg gagatggctt actcagaagc atactccact taacatacca tggcctgagc taagtaccat gtcctgtttg tgtcttattt ttaaatattt tctttgtcca catgggccgt tgaccttaga gttaaggcgg ttngcttttt tgaagaaatc anccaaagtt tctgggaaac tatgttncaa ggttgaaatg gagagtagat ttaattttat ttgtcttgta gggaagaaat cttcctttga accgcttttc ttgctttttc cctttttccc aaactaggtt acaggttctt atctgcaagg ttcaagttgc ttagacattg ttttccagta ttctgcaggg ccagtcagtt gtacagaagt &lt; 210> 493 &lt; 211 &gt; 500 &lt; 212〉 DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223〉 Probe 36014—at HG-U95Av2 240 300 360 420 480 540 541

&lt;221〉 misc—feature &lt;222〉 （49)..(67) &lt;223〉n 為 a, g，c 或 t &lt;400&gt; 493 60 120 gttctaagca tgcagttctc acctccattt agtcccccat cagaacagnn nnnnnnnnnn nnnnnnngga gcctaaattt agttcagctt acctttgaga atagcatcaa ttcagactct cttttcatta tgttttcttt tctttttccc tctttttaaa ctacattgtg ttagagtcat 98677.doc -399 - 180 200533758 agtctaggat tctttgtctg gtcaattggt tattagagag atctttgaat tactctagct cctgagagat ttgttggcat ttcctttctt actgtatata atgatgaata aatttgccat tttccattct agattctttt agcttgatat ttttttctaa aaagtgactg tgtcaccatt gtacatattt tgcctagctt atactttgtg tgagtgcaaa cacttgcatt atttatttgt tgttgtttta aaatcatttt tagaattagc gtaaagattt gtttatatat attaactttc tggtagcaat agtaagaagc&lt; 221〉 misc—feature &lt; 222〉 (49) .. (67) &lt; 223〉 n is a, g, c or t &lt; 400 &gt; 493 60 120 gttctaagca tgcagttctc acctccattt agtcccccat cagaacagnn nnnnnnnnnn nnnnnnngga gcacaatt acc ttcagactct cttttcatta tgttttcttt tctttttccc tctttttaaa ctacattgtg ttagagtcat 98677.doc -399 - 180 200533758 agtctaggat tctttgtctg gtcaattggt tattagagag atctttgaat tactctagct cctgagagat ttgttggcat ttcctttctt actgtatata atgatgaata aatttgccat tttccattct agattctttt agcttgatat ttttttctaa aaagtgactg tgtcaccatt gtacatattt tgcctagctt atactttgtg tgagtgcaaa cacttgcatt atttatttgt tgttgtttta aaatcatttt tagaattagc gtaaagattt gtttatatat attaactttc tggtagcaat agtaagaagc

&lt;210&gt; 494 &lt;211&gt; 153 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36250—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （52)..(66)&lt; 210 &gt; 494 &lt; 211 &gt; 153 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 36250-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222> (52) .. (66)

&lt;223〉 n 為 a，g，c 或 t &lt;400&gt; 494 gccccagacc cttgaaggaa ggtgctcccc ttcacacacc caggctggaa annnnnnnnn nnnnnngacg gcttgatggt agccaggacc tcctctttac tgcgggggtg ggcgggggcg gaggatggga actggctagt gagccctgaa ata &lt;210&gt; 495 &lt;211&gt; 317 98677.doc -400- 200533758 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 36336一s一at HG-U95Av2 &lt;400〉 495&Lt; 223> n is a, g, c or t &lt; 400 &gt; 494 gccccagacc cttgaaggaa ggtgctcccc ttcacacacc caggctggaa annnnnnnnn nnnnnngacg gcttgatggt agccaggacc tcctctttac tgcgggggtg ggcgggggcg gaggatggga actggctagt gagccctgaa ata &lt; 210 &gt; 495 &lt; 211 &gt; 317 98677.doc -400- 200533758 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220> &lt; 223 &gt; Probe 36336-s-at HG-U95Av2 &lt; 400> 495

60 120 180 240 300 317 cccggagagg tgctggacct cacctacagc cccccggccg aggccttccc gccgcccccg cacttctctt tcccggcgcc gctgtccctg gacgccggcc ccggcgtcgt gccgctgggc acccccgacg cccaggccga ccctgcggcc ctcgcgcacc agggctgcga catcaacttc aaggaggtgc tggaggacat gctgcgctcg ctgcacgcgg ggccgccctc cgagggcgcg ctgggggagg gcgcgggggc ggggggcgcg gcgggcggtg gtcccgagcg gcagagcgtg atccagttca gcccacc &lt;210〉 496 &lt;211&gt; 533 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 36497_at HG-U95Av2 &lt;220〉 &lt;221〉 misc一feature &lt;222〉 （26)..(26) &lt;223〉n 為 a，g，c 或 t &lt;400〉 496 60 attcacacgg tactcagagg cactgntggg gaagtttgtt ggtctttatt agataaattt ccagagacct gtccataata cccaacagaa catgactgtt tctttgagga aagggttata 98677.doc -401 · 120 20053375860 120 180 240 300 317 cccggagagg tgctggacct cacctacagc cccccggccg aggccttccc gccgcccccg cacttctctt tcccggcgcc gctgtccctg gacgccggcc ccggcgtcgt gccgctgggc acccccgacg cccaggccga ccctgcggcc ctcgcgcacc agggctgcga catcaacttc aaggaggtgc tggaggacat gctgcgctcg ctgcacgcgg ggccgccctc cgagggcgcg ctgggggagg gcgcgggggc ggggggcgcg gcgggcggtg gtcccgagcg gcagagcgtg atccagttca gcccacc &lt; 210> 496 &lt; 211 &gt; 533 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 36497_at HG-U95Av2 &lt; 220〉 &lt; 221〉 misc-feature &lt; 222〉 (26) .. (26) &lt; 223> n is a, g, c or t &lt; 400〉 496 60 attcacacgg tactcagagg cactgntggg gaagtttgtt ggtctttatt agataaattt ccagagacct gtccataata cccaacagaa catgactgtt tctttgagga aagggttata 98677.doc -401 · 120 200533758

atgtctgtgg tgtacaagtc gtttttggta taacttcttt cctgctgctg ctgcttcccg gcaaacatag ttttcctatt tcaggcagag tgcggtatat tccaggaaac actgtttcct actcacttag cttacttctt tgttgaatgc ctcactaatg gcaagtttca agatgttttg ggtgacaatg cacacatgct gggcaaaagg gtgatggcca gtggctggca gctgggccag cagaagctag gacatctgtg agttgtcatt ctcatctatc catgtccact ggcctgccag catccgccag tgccttgcca gtgtgcacgg tcccacactg tggcccctga gtcccctaat gtacacgctg cagccagaat gcagatggag ctggcttggc tgttccctgg atg &lt;210〉 497 &lt;211&gt; 471 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37030_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc—feature &lt;222〉 26, 51， 69, 92， 111， 120·.134, 145 &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221〉mi sc一feature &lt;222〉 285, 381， 383, 384, 386 &lt;223&gt; n 為 a，g, c 或 t &lt;400〉 497 ccacgactga agttgtagat tgagcngaat aaccatggga agtgaccaag ncaaagacac 98677.doc -402- 120 200533758 180 240 300 360 420 471atgtctgtgg tgtacaagtc gtttttggta taacttcttt cctgctgctg ctgcttcccg gcaaacatag ttttcctatt tcaggcagag tgcggtatat tccaggaaac actgtttcct actcacttag cttacttctt tgttgaatgc ctcactaatg gcaagtttca agatgttttg ggtgacaatg cacacatgct gggcaaaagg gtgatggcca gtggctggca gctgggccag cagaagctag gacatctgtg agttgtcatt ctcatctatc catgtccact ggcctgccag catccgccag tgccttgcca gtgtgcacgg tcccacactg tggcccctga gtcccctaat gtacacgctg cagccagaat gcagatggag ctggcttggc tgttccctgg atg &lt; 210> 497 &lt; 211 &gt; 471 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 37030_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc—feature &lt; 222〉 26, 51, 69, 92, 111, 120 · .134, 145 &lt; 223 &gt; n is a, g, c or t &lt; 220〉 &lt; 221〉 mi sc-feature &lt; 222〉 285, 381, 383, 384, 386 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 497 ccacgactga agttgtagat tgagcngaat aaccatggga agtgaccaag ncaaagacac 98677.doc -402- 120 200533758 180 240 300 360 420 471

tcgattggna gtcagttgaa tatttgtacc cntcagtgga gcccttctgg ntcttttctn nnnnnnnnnn nnnntttcct ctagncaaat acttctttct ccttgcttgc ctccaccatg atatttgaat aagagatggc cagaggataa cacttgtctc ttaaaaacta agctaaaaag aacctagaac cttcaattga gcagttgtga aaattgctaa tggtnccaag gccaagcaaa gagtttcaga aaatgactga gaaggagcga taacccccag aatgcaaaat caggggcatc attatccggt gcttgaacaa ngnngntccg ctctacaact ggttttttta ggacttgtga ggaacacagc aacggaaatc catccacaaa ggatgcagtg ccccaacttg t &lt;210&gt; 498 &lt;211&gt; 373 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37216.at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc一feature • &lt;222〉 （76)..(103) &lt;223&gt; n 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （215)..(237) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 498 accactgctc agaggagccc taggccctgg ccgcagtgcc ttcagcgccc gacccgggcc 60 98677.doc -403 - 120 200533758 cccacctggt cagccnnnnn nnnnnnnnnn nnnnnnnnnn nnnggccggg gcgtggcagg gccctctctg tgcctctcct cccaagtagg aaggggctcc gggtggctgc tctgggactg ggcacccaca agggctcagt gggcccaaac ccttnnnnnn nnnnnnnnnn nnnnnnncca agagctagaa actcaggaaa ccccaggtgc tcagggcccc gcgtctcggg ggctccgtgg ggcagacccc tgctaatata tgcaattctc cctcccccag cccttccctg acccctaagt tattgcccgc tea &lt;210〉 499 &lt;211&gt; 435 &lt;212&gt; DNA &lt;213&gt; 人類210 &gt;; tcgattggna gtcagttgaa tatttgtacc cntcagtgga ntcttttctn nnnnnnnnnn nnnntttcct ctagncaaat acttctttct ccttgcttgc ctccaccatg atatttgaat aagagatggc cagaggataa cacttgtctc ttaaaaacta agctaaaaag aacctagaac cttcaattga gcagttgtga aaattgctaa tggtnccaag gccaagcaaa gagtttcaga aaatgactga gaaggagcga taacccccag aatgcaaaat caggggcatc attatccggt gcttgaacaa ngnngntccg ctctacaact ggttttttta ggacttgtga ggaacacagc aacggaaatc catccacaaa ggatgcagtg ccccaacttg t & lt gcccttctgg 498 &lt; 211 &gt; 373 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 37216.at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; mi sc-feature • &lt; 222> (76) .. (76) .. 103) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (215) .. (237) &lt; 223 &gt; n is a, g, c or t &lt; 400〉 498 accactgctc agaggagccc taggccctgg ccgcagtgcc ttcagcgccc gacccgggcc 60 98677.doc -403-120 200533758 cccacctggt cagccnnnnn nnnnnnnnnnnnnnnnnnnnnn nnnggccggg gcgtggggggggccccctctggccccctctgg tctgggactg ggcacccaca agggctcagt gggcccaaac ccttnnnnnn nnnnnnnnnn nnnnnnncca agagctagaa actcaggaaa ccccaggtgc tcagggcccc gcgtctcggg ggctccgtgg ggcagacccc tgctaatata tgcaattctc cctcccccag cccttccctg acccctaagt tattgcccgc tea &lt; 210> 499 &lt; 211 &gt; 435 &lt; 212 &gt; DNA &lt; 213 &gt; Human

180 240 300 360 373 &lt;220〉 &lt;223〉 Probe 37786—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222〉 （113)..(113) &lt;223&gt; n 為 a，g，c 或 t180 240 300 360 373 &lt; 220〉 &lt; 223〉 Probe 37786-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc-feature &lt; 222〉 (113) .. (113) &lt; 223 &gt; n is a , G, c or t

&lt;220〉 &lt;221&gt; mi sc一feature &lt;222&gt; (262)..(263) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （265)..(265) &lt;223&gt; n 為 a，g，c 或 t 98677.doc -404- 60 60&lt; 220〉 &lt; 221 &gt; mi sc-feature &lt; 222 &gt; (262) .. (263) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222〉 (265) .. (265) &lt; 223 &gt; n is a, g, c or t 98677.doc -404- 60 60

200533758 &lt;400&gt; 499 cgtccattac tcaaggagac agcataacag atgcagaaca agtcatattt gaagaatgtt ttgtactaaa cttcatttaa ttattcagtt tttaaaggga aaaagggcgt ganctcacac agtgagctgt ttatttaaat atcattaagg agaaaaaaaa atatggtgag aagctcgctc ctttcaactt gtttggtact gacagctgat agaagctatt ttctaataat aaacatccag tgtgtgaaag acaaaaaaaa annantgcaa tactcttttt ttaatgataa aacctgtgaa gtttcccaaa gcaggtttta aaaggaaaaa aaggaaaagc aaaaaggttg ctgttctcac tcccatctca tttagtgcat gtcttaattc gggattagta atgaattgga ggatcattag acatttctag gaacc &lt;210&gt; 500 &lt;211&gt; 423 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 37788一at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 30, 352, 364..366, 368..373, 376..389, 391, 392 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 500 catgaatcac atagagcagt ggagttttan ccaagtggtg tgtgtggttt ttgtttttta ctatgcaaag atgggaaatg cacaaacttt tcaaagacta gtgtctgaag aactttacaa 120 180 240 300 360 420 435 60 98677.doc -405 - 120 180 200533758 acaatacttg aaccctttct ttaaagttat cccatcatgt tttatagtca ttgttgcttc cattgttagt ttccattttc aagtgctttg taatttttta agtgcactac ctgaaatttt gtttgaaatt aataaattca ttcgtatctt gttggctgcc tatgaatgga gattcagtag tcattgtatg catctttaag tcaaatgtgt attaaaactt tcgttaacgt anaaaaaaaa aaannnannn nnnaannnnn nnnnnnnnnc nnccttttct gtttcctctt gtagtgctga t ta 240 300 360 420 423200533758 &lt; 400 &gt; 499 cgtccattac tcaaggagac agcataacag atgcagaaca agtcatattt gaagaatgtt ttgtactaaa cttcatttaa ttattcagtt tttaaaggga aaaagggcgt ganctcacac agtgagctgt ttatttaaat atcattaagg agaaaaaaaa atatggtgag aagctcgctc ctttcaactt gtttggtact gacagctgat agaagctatt ttctaataat aaacatccag tgtgtgaaag acaaaaaaaa annantgcaa tactcttttt ttaatgataa aacctgtgaa gtttcccaaa gcaggtttta aaaggaaaaa aaggaaaagc aaaaaggttg ctgttctcac tcccatctca tttagtgcat gtcttaattc gggattagta atgaattgga ggatcattag acatttctag gaacc &lt; 210 &gt; 500 &lt; 211 &gt; 423 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 37788a at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 30, 352, 364..366, 368..373, 376..389, 391, 392 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 500 catgaatcac atagagcagt ggagttttan ccaagtggtg tgtgtggtttt ttgtttttta ctatgcaacacagactaggagatacta aggagatacta 120 180 240 300 360 420 435 60 98677.doc -405-120 180 200533758 acaatacttg aaccctttct ttaaagttat c ccatcatgt tttatagtca ttgttgcttc cattgttagt ttccattttc aagtgctttg taatttttta agtgcactac ctgaaatttt gtttgaaatt aataaattca ttcgtatctt gttggctgcc tatgaatgga gattcagtag tcattgtatg catctttaag tcaaatgtgt attaaaactt tcgttaacgt anaaaaaaaa aaannnannn nnnaannnnn nnnnnnnnnc nnccttttct gtttcctctt gtagtgctga t ta 240 300 360 420 423

&lt;211〉 411 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223〉 Probe 38393一at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （90)..(91) &lt;223&gt; n 為 a，g，c 或 t&lt; 211〉 411 &lt; 212〉 DNA &lt; 213 &gt; Humans &lt; 220〉 &lt; 223〉 Probe 38393-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222> (90). (91) ) &lt; 223 &gt; n is a, g, c or t

&lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （97)..(116) &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc一feature &lt;222〉 （172)..(172) &lt;223&gt; n 為 a，g，c 或 t 98677.doc -406- 200533758 &lt;220〉 &lt;221〉mi sc—feature &lt;222〉 （30)..(30) &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 501&lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222> (97) .. (116) &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc-feature &lt; 222> ( 172) .. (172) &lt; 223 &gt; n is a, g, c or t 98677.doc -406- 200533758 &lt; 220〉 &lt; 221〉 mi sc-feature &lt; 222> (30) .. (30) ) &lt; 223> n is a, g, c or t &lt; 400 &gt; 501

60 120 180 240 300 360 411 cccaaggtgg gacttggaga atattttgcn ttggcatatg tttggtctga atggtgtagt tgctggttcc ctagagagga aaaggtggcn nggcccnnnn nnnnnnnnnn nnnnnnctta atttccagtt gaaaccctag tagaattgtg aatgaaaacc tcaaggttga gncccctctg ccaagcagca gagctagtag aaggggatgc aggggcaaag cactcagttg ccaagcaagg aggagagatg tacgtgggct gtgtggcagt ccccacaccc tgccctggct tcttcaggtt atcgcaccac tatggaatcc tttgcagaat ggtactcata taatggttta aaacaacaca ttcataattg actctgtgca ggatgtcact caatcagttt gggtttgctt t &lt;210&gt; 502 &lt;211&gt; 480 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38510_at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc—feature &lt;222&gt; 88, 97, 101, 105, 107, 108, 116, 120, 122, 130, 136, 158 &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; mi sc—feature 98677.doc -407-60 120 180 240 300 360 411 cccaaggtgg gacttggaga atattttgcn ttggcatatg tttggtctga atggtgtagt tgctggttcc ctagagagga aaaggtggcn nggcccnnnn nnnnnnnnnn nnnnnnctta atttccagtt gaaaccctag tagaattgtg aatgaaaacc tcaaggttga gncccctctg ccaagcagca gagctagtag aaggggatgc aggggcaaag cactcagttg ccaagcaagg aggagagatg tacgtgggct gtgtggcagt ccccacaccc tgccctggct tcttcaggtt atcgcaccac tatggaatcc tttgcagaat ggtactcata taatggttta aaacaacaca ttcataattg actctgtgca ggatgtcact caatcagttt gggtttgctt t &lt; 210 &gt; 502 &lt; 211 &gt; 480 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 38510_at HG-U95Av2 &lt; 220> &lt; 221 &gt; mi sc-feature &lt; 222 &gt; 88, 97, 101, 105, 107, 108, 116, 120, 122, 130, 136, 158 &lt; 223> n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; mi sc—feature 98677.doc- 407-

200533758 &lt;222〉 186, 189, 192， 194, 197, 203, 206..210, 213..215, 217 &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 223, 251， 268, 301 &lt;223〉n 為 a，g，c 或 t &lt;400〉 502 gtcctcccat attggcaaag ataaagcaat tgacaaaaat ggaattcttg ttcaatactg gcaggagtga aaattggtag aacctttnta gaaggcnatt nggcnannat gtatgnaaan cntaaatgtn gatacncctt tacccagcag tttgtttngg aatttatcct aatgaataaa agttgnccna gncntcnaaa cangannnnn aannnanatt tcnatgatgt ttatgatatt aaaacattgg naacaactga aacatccntc agtaaaagat ggattaaata aattccatgc nagttgtcat ttaaaaatat ttagatatat gtttattgct atggatatat gttcccaaaa tattattgaa tcaaaaagta gactacagga tatatgttga atatgagctc atttataaca ttgaatattt taagataatg tatgtttcat agagagatct tcaccaaatg ttaaggattt 60 120 180 240 300 360 420 480200533758 &lt; 222〉 186, 189, 192, 194, 197, 203, 206..210, 213..215, 217 &lt; 223 &gt; η is a, g, c or t &lt; 220〉 &lt; 221 &gt; mi sc-feature &lt; 222〉 223, 251, 268, 301 &lt; 223〉 n is a, g, c or t &lt; 400〉 502 gtcctcccat attggcaaag ataaagcaat tgacaaaaat ggaattcttg ttcaatacta tca nt acntcnt acnt ag tat ng agttgnccna gncntcnaaa cangannnnn aannnanatt tcnatgatgt ttatgatatt aaaacattgg naacaactga aacatccntc agtaaaagat ggattaaata aattccatgc nagttgtcat ttaaaaatat ttagatatat gtttattgct atggatatat gttcccaaaa tattattgaa tcaaaaagta gactacagga tatatgttga atatgagctc atttataaca ttgaatattt taagataatg tatgtttcat agagagatct tcaccaaatg ttaaggattt 60 120 180 240 300 360 420 480

&lt;210&gt; 503 &lt;211&gt; 385 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38717,at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （76)..(76) 98677.doc 408- 200533758 &lt;223&gt; η 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （100)..(100) &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 503&lt; 210 &gt; 503 &lt; 211 &gt; 385 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 38717, at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222> (76 ) .. (76) 98677.doc 408- 200533758 &lt; 223 &gt; η is a, g, c or t &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222> (100) .. (100) &lt; 223 &gt; n is a, g, c or t &lt; 400> 503

60 120 180 240 300 360 385 tacaaggttg ccacacctag ttctgcccag ctttatgtct tttattccag tattccacca aagtttgttt tcctgncatt ccagttctca agtcttaagn ataaagattg tacttgacag tttagtatat ccataaaact atttgaggtg gttaaggttc ttgggttcat tttccttaat actttgctga atattgtaga ttgtaggcaa tgaaaaagtc tactaaatta ggaaaacctt gaataattag gtatcctagg taagagcccc taaacatcaa gcaatctgtg agtctgtaaa gaaataaata ttttttggat tattcttatc taattccacc cctgttggaa gatgatttct ttgttctttg caactatgga agctg &lt;210&gt; 504 &lt;211&gt; 581 &lt;212〉 DNA &lt;213〉 人類 &lt;220〉 &lt;223&gt; Probe 38749—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222&gt; 102, 166, 299, 494, 496..503, 506..509, 517..523, 546, 555 &lt;223〉n 為 a，g，c 或 t 98677.doc -409- 60 20053375860 120 180 240 300 360 385 tacaaggttg ccacacctag ttctgcccag ctttatgtct tttattccag tattccacca aagtttgttt tcctgncatt ccagttctca agtcttaagn ataaagattg tacttgacag tttagtatat ccataaaact atttgaggtg gttaaggttc ttgggttcat tttccttaat actttgctga atattgtaga ttgtaggcaa tgaaaaagtc tactaaatta ggaaaacctt gaataattag gtatcctagg taagagcccc taaacatcaa gcaatctgtg agtctgtaaa gaaataaata ttttttggat tattcttatc taattccacc cctgttggaa gatgatttct ttgttctttg caactatgga agctg &lt; 210 &gt; 504 &lt; 211 &gt; 581 &lt; 212〉 DNA &lt; 213> Human &lt; 220> &lt; 223 &gt; Probe 38749-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222 &gt; 102, 166, 299, 494, 496..503, 506..509, 517..523, 546, 555 &lt; 223〉 n is a, g, c or t 98677.doc -409- 60 200533758

&lt;400&gt; 504 ggcggcagca cagcacctgc acgaacaccc ggagcgggtt gatgaccgag ctgaggtaga atgtacgccc ggaagtagga cctcgtccag ctccgaatct ggttgggcat ccagcatacg acacgagcag gagggagaga cagagaaaag ataaaaccat aaaatattta gcccctctgt atttttcagt gttggacttg acagcttctt tttcaaaccc gggggagttg gctgtgttaa aaaaaaaaaa aaanannnnn nnnaannnna tatccngaaa gcagntcatg ttatccataa gccgaaactg ctgcgaggac accgtgtaca aaaacgtctc cngagaaggg gaggaggatc tcgtgcttgg gtttgnccgc agccatgatc gccaatgtca caacaatcag ccctgggcag aaaaacacag catgagaaca cagtaaatna tctgtgctta ctggccagga aatggtacca ttgccacaag caagagagaa tttaacactg agaaagacca ttaaatgctt tagacagtgt aaaaaannnn nnnattggtg tttgtttgcg atctggtttt g 120 180 240 300 360 420 480 540 581&Lt; 400 &gt; 504 ggcggcagca cagcacctgc acgaacaccc ggagcgggtt gatgaccgag ctgaggtaga atgtacgccc ggaagtagga cctcgtccag ctccgaatct ggttgggcat ccagcatacg acacgagcag gagggagaga cagagaaaag ataaaaccat aaaatattta gcccctctgt atttttcagt gttggacttg acagcttctt tttcaaaccc gggggagttg gctgtgttaa aaaaaaaaaa aaanannnnn nnnaannnna tatccngaaa gcagntcatg ttatccataa gccgaaactg ctgcgaggac accgtgtaca aaaacgtctc cngagaaggg gaggaggatc tcgtgcttgg gtttgnccgc agccatgatc gccaatgtca caacaatcag ccctgggcag aaaaacacag catgagaaca cagtaaatna tctgtgctta ctggccagga aatggtacca ttgccacaag caagagagaa tttaacactg agaaagacca ttaaatgctt tagacagtgt aaaaaannnn nnnattggtg tttgtttgcg atctggtttt g 120 180 240 300 360 420 480 540 540 581

&lt;210&gt; 505 &lt;211〉 421 &lt;212〉 DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 38972_at HG-U95Av2 &lt;220〉 &lt;221&gt; miscjeature &lt;222〉 （144)·.(144) &lt;223〉 n 為 a，g，c 或 t &lt;400&gt; 505 98677.doc -410-&lt; 210 &gt; 505 &lt; 211〉 421 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 38972_at HG-U95Av2 &lt; 220> &lt; 221 &gt; miscjeature &lt; 222〉 (144) · . (144) &lt; 223> n is a, g, c or t &lt; 400 &gt; 505 98677.doc -410-

200533758 cgttagtaac catttagtga caaaggatta aaacatccat ctggatgtta attttgaaga tgtaaattat atgttgttta aatttttcca ggcatctgaa aaccttatct gctagacaat gtaagattca cacagagtta tctngggatt ctgatttttt aaatagtaca tatcattaaa ccattttctc taaatgtaag aagagcagaa aaaatcttat aagattatca gatttttcta atgacacaga aatgtaagaa aaaaatccct ttatattgaa aaaagatgca gtcaaagtct tttcagacat gcccaaactt tgagaatttc ttcaaccatc taatgctata aagatttttg ttcttcctgt tcacaaccag ttgtataaca gaaatactag ctactgtttt ccttcctgtg &lt;210〉 506 &lt;211&gt; 431 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 39582一at HG-U95Av2 &lt;220&gt; &lt;221〉 misc一feature &lt;222〉 （125)..(125) &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 506 ggccacaaat ggagggattg tcctttcaag caccacagct tcagataaaa ttagtacttt caaatattgt ccactttaac ttaaaaaatt ctagagggat tatattggag actcaactgc ccttnggttt tagtttataa aatggcctag tactgtggaa ttttaatttt agaaagtctt 98677.doc -411 - 200533758 agcatcagat cataaacatt cattaaaaga actcacatcc catctgaaac ttcccagggg agttgggatt cttagtagat tggtagaaag gggctcattt tctactgcat ttcccatttt tggtatcttg ttcagcatgt tttattttta tttcttgtct gcagaacatc ctatatttat gagaacattc tttaagaaga ccaccacata gaatacccct tcctatcagc tcgctctgat ttagccttaa t &lt;210〉 507 &lt;211&gt; 355 W &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 39597—at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （50)·.(50) &lt;223&gt; n 為 a，g，c 或 t200533758 cgttagtaac catttagtga caaaggatta aaacatccat ctggatgtta attttgaaga tgtaaattat atgttgttta aatttttcca ggcatctgaa aaccttatct gctagacaat gtaagattca cacagagtta tctngggatt ctgatttttt aaatagtaca tatcattaaa ccattttctc taaatgtaag aagagcagaa aaaatcttat aagattatca gatttttcta atgacacaga aatgtaagaa aaaaatccct ttatattgaa aaaagatgca gtcaaagtct tttcagacat gcccaaactt tgagaatttc ttcaaccatc taatgctata aagatttttg ttcttcctgt tcacaaccag ttgtataaca gaaatactag ctactgtttt ccttcctgtg &lt; 210> 506 &lt; 211 &gt; 431 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220〉 &lt; 223 &gt; Probe 39582-at HG-U95Av2 &lt; 220 &gt; &lt; 221〉 misc-feature &lt; 222〉 (125) .. (125). ) &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 506 ggccacaaat ggagggattg tcctttcaag caccacagct tcagataaaa ttagtacttt caaatattgt ccactttaac ttaaaaaatt ctagagggat tatattggag actcaactgc ccttnggttt tagtttataa aatggcctag tactgtggaa ttttaatttt agaaagtctt 98677.doc -411 - 200533758 agcatcagat cataaacatt cattaaaaga actcacatcc catctgaaac ttcccagggg agttggga tt cttagtagat tggtagaaag gggctcattt tctactgcat ttcccatttt tggtatcttg ttcagcatgt tttattttta tttcttgtct gcagaacatc ctatatttat gagaacattc tttaagaaga ccaccacata gaatacccct tcctatcagc tcgctctgat ttagccttaa t &lt; 210> 507 &lt; 211 &gt; 355 W &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 39597-at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> (50) ·. (50) &lt; 223 &gt; n is a, g, c or t

&lt;220〉 &lt;221&gt; misc^feature &lt;222〉 （184)..(184) &lt;223〉n 為 a，g，c 或 t &lt;400&gt; 507 caaacataac gttaatgaaa atctgaggaa ggatgtaagg agtcatatgc attcaggaag cagaaagtga agctagagca gatctttgta tcggagaagg gacccaggaa gattgggggg aatgagaaan agctttctgg agattctaaa tgtgcgtgat aagagattgc ttgaaggggt 98677.doc -412- 200533758 gatngggtga ggggccagag ggaagtctgc tgtgttctca tgtaggatgt cagccctccc tgcaacttct ctttttggcc aatgtctttt cactttcctg accctttaga atcatcccca gccagacgca atcatggaag ttgccttatt gtcactggtt aagaacttgg cgaga &lt;210&gt; 508 &lt;211&gt; 570 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; • &lt;223&gt; Probe 39602_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; (101)..(116) &lt;223&gt; n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; mi sc一feature &lt;222〉 （247)..(324) &lt;223〉n 為 a，g，c 或 t&lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222〉 (184) .. (184) &lt; 223> n is a, g, c or t &lt; 400 &gt; 507 caaacataac gttaatgaaa atctgaggaa ggatgtaagg agtcatatgc attcaggaag cagaaagtga agctggag tcggagaagg gacccaggaa gattgggggg aatgagaaan agctttctgg agattctaaa tgtgcgtgat aagagattgc ttgaaggggt 98677.doc -412- 200533758 gatngggtga ggggccagag ggaagtctgc tgtgttctca tgtaggatgt cagccctccc tgcaacttct ctttttggcc aatgtctttt cactttcctg accctttaga atcatcccca gccagacgca atcatggaag ttgccttatt gtcactggtt aagaacttgg cgaga &lt; 210 &gt; 508 &lt; 211 &gt; 570 &lt; 212> DNA &lt; 213 &gt; Human &lt; 220 &gt; • &lt; 223 &gt; Probe 39602_at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; (101) .. (116) &lt; 223 &gt; n is a, g, c Or t &lt; 220〉 &lt; 221 &gt; mi sc-feature &lt; 222〉 (247) .. (324) &lt; 223> n is a, g, c or t

&lt;400〉 508 gggtctacat taatcttcca gtactccttg ctgatgctgt gttatgtgtc atctaacaga aatgactcct ttgaaataag taaatctttg gctttttgtt nnnnnnnnnn nnnnnnaagc aaaacaaaca aacaaaaaca aattttaaga acacaacaaa aaagatttga cttccgaata gaatgttttc tttaagaggc atgaaaagca actattgttg tgttacagtg ttaaaaatat tcagttnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 98677.doc -413 360 200533758 nnnnnnnnnn nnnnnnnnnn nnnntgtggc atctgaactt ttataaaggt ttccttgtgc caaataagtg caaagattta atttactatt aaaaaccata agcatatgtt atagttccag aagaattatt ttgtcatcaa gtgattttga tctttagtgt caatatttat atttagatta atttttataa atgaaaatat tttaatggtt taagaaaatg aggacaacag gataatatct ttgatgactt ctgaaagtta tgcttccctt &lt;210〉 509 &lt;211〉 427 w &lt;212&gt; DNA &lt;213〉人類 &lt;220&gt; &lt;223&gt; Probe 39827_at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 132..166, 168..178, 181..184, 187..190, 193, 194 &lt;223〉n 為 a，g，c 或 t &lt;220〉&Lt; 400> 508 gggtctacat taatcttcca gtactccttg ctgatgctgt gttatgtgtc atctaacaga aatgactcct ttgaaataag taaatctttg gctttttgtt nnnnnnnnnn nnnnnnaagc aaaacaaaca aacaaaaaca aattttaaga acacaacaaa aaagatttga cttccgaata gaatgttttc tttaagaggc atgaaaagca actattgttg tgttacagtg ttaaaaatat tcagttnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 98677.doc -413 360 200533758 nnnnnnnnnn nnnnnnnnnn nnnntgtggc atctgaactt ttataaaggt ttccttgtgc caaataagtg caaagattta atttactatt aaaaaccata agcatatgtt atagttccag aagaattatt ttgtcatcaa gtgattttga tctttagtgt caatatttat atttagatta atttttataa atgaaaatat tttaatggtt taagaaaatg aggacaacag gataatatct ttgatgactt ctgaaagtta tgcttccctt &lt; 210> 509 &lt; 211> 427 w &lt; 212 &gt; DNA &lt; 213> human &lt; 220 &gt; &lt; 223 &gt; Probe 39827_at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_feature &lt; 222 &gt; 132..166, 168..178, 181..184, 187..190, 193, 194 &lt; 223> n is a, g, c Or t &lt; 220>

420 480 540 570 &lt;221&gt; misc^feature &lt;222&gt; 198..203, 205..208, 341..358 &lt;223&gt; n 為 a，g，c 或 t &lt;400&gt; 509 60 120 180 acgtgctcct cagagcagcc ggagggaggg gggaggtcgg aggtcgtgga ggtggtttgt gtatcttact ggtctgaagg gaccaagtgt gtttgttgtt tgttttgtat cttgtttttc tgatcggagc annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnannn nnnnnnnnaa nnnnagnnnn ggnngggnnn nnngnnnngg atcacttggg atctttgaca cttgaaaaat 98677.doc -414- 240 200533758 tacacctggc agctgcgttt aagccttccc ccatcgtgta ctgcagagtt gagctggcag 300 gggaggggct gagagggtgg gggctggaac ccctccccgg nnnnnnnnnn nnnnnnnnct 360 tccatctaga actgtttaca tgaagataag atactcactg ttcatgaata cacttgatgt 420 tcaagta 427 &lt;210&gt; 510 &lt;211&gt; 265 &lt;212&gt; DNA ♦ &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 39837—s—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc^feature &lt;222〉 85, 86, 95， 133 &lt;223&gt; n 為 a，g，c 或 t &lt;400〉 510420 480 540 570 &lt; 221 &gt; misc ^ feature &lt; 222 &gt; 198..203, 205..208, 341..358 &lt; 223 &gt; n is a, g, c or t &lt; 400 &gt; 509 60 120 180 acgtgctcct cagagcagcc ggagggaggg gggaggtcgg aggtcgtgga ggtggtttgt gtatcttact ggtctgaagg gaccaagtgt gtttgttgtt tgttttgtat cttgtttttc tgatcggagc annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnannn nnnnnnnnaa nnnnagnnnn ggnngggnnn nnngnnnngg atcacttggg atctttgaca cttgaaaaat 98677.doc -414- 240 200533758 tacacctggc agctgcgttt aagccttccc ccatcgtgta ctgcagagtt gagctggcag 300 gggaggggct gagagggtgg gggctggaac ccctccccgg nnnnnnnnnn nnnnnnnnct 360 tccatctaga actgtttaca tgaagataag atactcactg ttcatgaata cacttgatgt 420 tcaagta 427 &lt; 210 &gt; 510 &lt; 211 &gt; 265 &lt; 212 &gt; DNA ♦ &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 39837-s-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc ^ feature &lt; 222〉 85, 86, 95, 133 &lt; 223 &gt; n is a, g, c or t &lt; 400〉 510

cctagttctc acgaggaccc tttcttgccc acagtttcga gaggcccgtg ccatgagacc 60 gcctggggtg agcaaggcga cctgnnctgc tgccngaagg tttggccgcc gcgggacacc 120 tgtttccttc ccncagtgtc tgcgtccgca cagcataccc agctcggacc tcctaggaca 180 gagactcagc gaacccttgc tgggaaccgc tgagctgaag ttcttggaag gctcccaccc 240 aggtgccccg ttggaaagca gatat 265 &lt;210〉 511 &lt;211&gt; 211 98677.doc 415- 200533758 &lt;212〉 DNA &lt;213〉人類 &lt;220&gt; &lt;223〉Probe 40239at HG-U95Av2cctagttctc acgaggaccc tttcttgccc acagtttcga gaggcccgtg ccatgagacc 60 gcctggggtg agcaaggcga cctgnnctgc tgccngaagg tttggccgcc gcgggacacc 120 tgtttccttc ccncagtgtc tgcgtccgca cagcataccc agctcggacc tcctaggaca 180 gagactcagc gaacccttgc tgggaaccgc tgagctgaag ttcttggaag gctcccaccc 240 aggtgccccg ttggaaagca gatat 265 &lt; 210> 511 &lt; 211 &gt; 211 98677.doc 415- 200533758 &lt; 212> DNA &lt; 213> Human &lt; 220 &gt; &lt; 223> Probe 40239at HG-U95Av2

&lt;400〉 511 tataagtatg gcatttaata aaagcacctg gccacaatgc caacagtcag aatatatatt ctgagaactc tccctttcaa ccgggggaag atctatcaaa ctgtaagctg cttggggttt ataaaggtac agtgagcctt gtatcatcat g attataaaac agctcttcat tgcatcattg acacattaat cagttaataa gattataaaa 60 120 180 211 &lt;210〉 512 &lt;211&gt; 419 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 40472_at HG-U95Av2 &lt;220&gt; &lt;221〉 &lt;222&gt; &lt;223&gt;&Lt; 400> 511 tataagtatg gcatttaata aaagcacctg gccacaatgc caacagtcag aatatatatt ctgagaactc tccctttcaa ccgggggaag atctatcaaa ctgtaagctg cttggggttt ataaaggtac agtgagcctt gtatcatcat g attataaaac agctcttcat tgcatcattg acacattaat cagttaataa gattataaaa 60 120 180 211 &lt; 210> 512 &lt; 211 &gt; 419 &lt; 212 &gt; DNA &lt; 213 &gt; Human &lt; 220 &gt; &lt; 223 &gt; Probe 40472_at HG-U95Av2 &lt; 220 &gt; &lt; 221> &lt; 222 &gt; &lt; 223 &gt;

misc^feature (44)..(58) n 為 a, g，c 或 t &lt;220&gt; &lt;221&gt; misc—feature &lt;222〉 （63)..(139) &lt;223〉n 為 a，g，c 或 t &lt;220&gt; &lt;221&gt; misc_feature 98677.doc -416- 60 200533758 &lt;222&gt; (26)..(29) &lt;223〉η 為 a，g，c 或 t &lt;400〉 512 ttgctgaaga gcaagcagag ggtccnnnnc gcctgctgta caannnnnnn nnnnnnnnca tcnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna ggcctctccc tctgtcagtt ccagaacttc tccctccatg acccactcta tgggaaactc ttcagcacct acctgcgccc cccacacacc tctcgaggcamisc ^ feature (44) .. (58) n is a, g, c or t &lt; 220 &gt; &lt; 221 &gt; misc—feature &lt; 222〉 (63) .. (139) &lt; 223〉 n is a , G, c or t &lt; 220 &gt; &lt; 221 &gt; misc_feature 98677.doc -416- 60 200533758 &lt; 222 &gt; (26) .. (29) &lt; 223> η is a, g, c or t &lt; 400> 512 ttgctgaaga gcaagcagag ggtccnnnnc gcctgctgta caannnnnnn nnnnnnnnca tcnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna ggcctctccc tctgtcagtt ccagaacttc tccctccatg acccactcta tgggaaactc ttcagcacct acctgcgccc cccacacacc tctcgaggca

120 180 240 300 360 419 cctcccagac accaaatgcc tcatccccag gcaaccccac tgctctggcc aatgggactg tgcaagcacc caagcagaag ggagactgag tgcctcagcc tctcaccccc tcctcctcag ggcagcgcta ggggcctccc ctatgcctca gccccatctc tgctcctgtt tgaattttg &lt;210〉 513 &lt;211&gt; 477 &lt;212&gt; DNA &lt;213&gt;人類 _ &lt;220〉 &lt;223〉 Probe 40642—at HG-U95Av2 &lt;220〉 &lt;221&gt; mi sc一feature &lt;222&gt; (34)..(52) &lt;223〉n 為 a，g，c 或 t &lt;220〉 &lt;221&gt; misc_feature &lt;222〉 （198)..(198) &lt;223〉 n 為 a，g，c 或 t 98677.doc -4P- 60 200533758 &lt;400&gt; 513120 180 240 300 360 419 cctcccagac accaaatgcc tcatccccag gcaaccccac tgctctggcc aatgggactg tgcaagcacc caagcagaag ggagactgag tgcctcagcc tctcaccccc tcctcctcag ggcagcgcta ggggcctccc ctatgcctca gccccatctc tgctcctgtt tgaattttg &lt; 210> 513 &lt; 211 &gt; 477 &lt; 212 &gt; DNA &lt; 213 &gt; human _ &lt; 220> &lt; 223> Probe 40642-at HG-U95Av2 &lt; 220> &lt; 221 &gt; mi sc-feature &lt; 222 &gt; (34) .. (52) &lt; 223> n is a, g, c or t &lt; 220 〉 &Lt; 221 &gt; misc_feature &lt; 222〉 (198) .. (198) &lt; 223〉 n is a, g, c or t 98677.doc -4P- 60 200533758 &lt; 400 &gt; 513

120 180 240 300 360 420 477 taagcccttg atgacttatt gcatgataca gtannnnnnn nnnnnnnnnn nntaaataca tgaaaagcag tgtaagctag tgacactaaa gccagtcttg tattactgta tttttgacag aatggttttg aaaactgtgc tacagggact gatgtggcaa atatatctct ttatgcagaa ggaagtcttt ttttttcntt tttttttttt taagaagtat ggctttttat gcatccttca tcgagggcat tgaagttgca tggactgata aaagttgatg caaaacaaga aagaaacaaa caaaaaaaaa aaaccagcaa aatgtttacc aaaaaactca aacaaatgag cagtgcctgt tcaatttcac agtctctgtt gagttcagtt gtaaatatgt ttcaaatgac attttcttgg gaaaaaaaat ctctacaaca ttgtagaatg tgaggggtaa ctacatccca ggcatag &lt;210〉 514 &lt;211&gt; 375 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220〉 &lt;223&gt; Probe 40855_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 （283)..(301) &lt;223〉n 為 a，g, c 或 t &lt;400&gt; 514 60 ctcatgtatt tatgcctaat gtaagctgac ttttaaaaag ctttcttttg ttgcatgccc tgtgcaggca tctgtattgt acatgcatgc ctttcgtcct gttttcctgt ataaagttag 98677.doc -418- 120 200533758 tgaacaaaga aatatttttg cctagttcat gttgccaagc aatgcatatt ttttaaattt gtcatatatg gaaagagcat gtttgttaca tgtaaaagct ttactgatat acagatatac taatgtttga agatgctgtt ctttgcaagt gtacagtttt cannnnnnnn nnnnnnnnnn ncacccttgt ggtttaaact tgctacaatg tatttattat tcatttcctc ccatgtaact aagaatcatg gctat120 180 240 300 360 420 477 taagcccttg atgacttatt gcatgataca gtannnnnnn nnnnnnnnnn nntaaataca tgaaaagcag tgtaagctag tgacactaaa gccagtcttg tattactgta tttttgacag aatggttttg aaaactgtgc tacagggact gatgtggcaa atatatctct ttatgcagaa ggaagtcttt ttttttcntt tttttttttt taagaagtat ggctttttat gcatccttca tcgagggcat tgaagttgca tggactgata aaagttgatg caaaacaaga aagaaacaaa caaaaaaaaa aaaccagcaa aatgtttacc aaaaaactca aacaaatgag cagtgcctgt tcaatttcac agtctctgtt gagttcagtt gtaaatatgt ttcaaatgac attttcttgg gaaaaaaaat ctctacaaca ttgtagaatg tgaggggtaa ctacatccca ggcatag &lt; 210> 514 &lt; 211 &gt; 375 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220〉 &lt; 223 &gt; Probe 40855_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misa 〉 (283) .. (301) &lt; 223〉 n is a, g, c or t &lt; 400 &gt; 514 60 ctcatgtatt tatgcctaat gtaagctgac ttttaaaaag ctttcttttttg ttgcatgccc tgtgcaggca tctgtattgt acatgcatgc ctttcgt aca tdoctt aca tctttgt aca cctagttcat gttgccaagc aatgcatatt tttt aaattt gtcatatatg gaaagagcat gtttgttaca tgtaaaagct ttactgatat acagatatac taatgtttga agatgctgtt ctttgcaagt gtacagtttt cannnnnnnn nnnnnnnnnn ncacccttgt ggtttaaact tgctacaatg tttcc

&lt;210〉 515 &lt;211&gt; 491 &lt;212&gt; DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 41229—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_feature &lt;222&gt; 85..108, 166, 173, 182, 185..215 &lt;223〉n 為 a，g，c 或 t &lt;400〉 515 caacttttgt aggactgtgt agtcagttat tgcttgctag ttgtcctcat gggccataaa anggnnnnnn nnnnnnnnnn gttacttaat ttctagagtt gtgaaggttt tattgtgccc gtttctttag atacatttag ctacnnnnnn nnnnnnnnnn tacagaacct tgtattttaa nnnnnnnnnn nnnnttagea caggcctctg ggatcaaccc ggttggagga taacgttctt tacaactgta ggtgacgagt nnnnnnnnac ttttggcatt ttaaantttt ttncaaaagg gtaggatgta ttatacgaca cagactgggc cagaatgtta tgggtacttt ttgtgggttg 98677.doc -419- 200533758 caaatgaact caattgccac aagttttaaa ctggtgtaaa tcaagcttga cttaatgtga ttgttactgt tatatccagc ctatactgct agcagctgct catactgcag tcaattactg gaagcggata t &lt;210&gt; 516 &lt;211&gt; 438 &lt;212〉 DNA &lt;213&gt;人類&lt; 210> 515 &lt; 211 &gt; 491 &lt; 212 &gt; DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 41229-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc_feature &lt; 222 &gt; 85. .108, 166, 173, 182, 185..215 &lt; 223〉 n is a, g, c or t &lt; 400〉 515 caacttttgt aggactgtgt agtcagttat tgcttgctag ttgtcctcat gggccataaa anggnnnnnn nntnntnntnnctnnt gttacttaat ttctagann gtn gt gt nnnnttagea caggcctctg ggatcaaccc ggttggagga taacgttctt tacaactgta ggtgacgagt nnnnnnnnac ttttggcatt ttaaantttt ttncaaaagg gtaggatgta ttatacgaca cagactgggc cagaatgtta tgggtacttt ttgtgggttg 98677.doc -419- 200533758 caaatgaact caattgccac aagttttaaa ctggtgtaaa tcaagcttga cttaatgtga ttgttactgt tatatccagc ctatactgct agcagctgct catactgcag tcaattactg gaagcggata t &lt; 210 &gt; 516 &lt; 211 &gt; 438 &lt; 212〉 DNA &lt; 213 &gt; human

&lt;220〉 &lt;223&gt; Probe 41690—at HG-U95Av2 &lt;220〉 &lt;221&gt; misc一feature &lt;222&gt; (26)..(44) &lt;223〉n 為 a，g，c 或&lt; 220> &lt; 223 &gt; Probe 41690-at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc-feature &lt; 222 &gt; (26) .. (44) &lt; 223> n is a, g, c or

&lt;400〉 516 ttgccctggt ggctgttagt agcagcataa atacttttgg agcaacatgg gcattagttt gttttccaaa gagacccata gtatttgata tctcttggct tgattccagc cccagtgata aaacactacc ttgtacttat ccattnnnnn ttctgcctgt gtttatactt tatgtaacct ttatatagtt agaagaatgc tactgctttt nnnnnnnnnn ctcctcatgg ttttaaactt ctatgctctg tcccaatgga tgagccaact gatactgtat nnnncttaaa ttgaaatatg tcctgtgttg taaggtgatt gaggttattg ataaacactc tacgtgccaa gtccagtgtt tctgaagaat taaatattgt atttgtatat agtaaccttt aattttgtat tagtttccca atcacatagc aggcaaga 980^7.cloc -420- 200533758 &lt;210&gt; 517 &lt;211〉 416 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 41710^at HG-U95Av2 &lt;220〉 &lt;221&gt; misc__feature &lt;222〉 （124)..(145) 擊 &lt;223〉n 為 a，g，c 或 t&Lt; 400> 516 ttgccctggt ggctgttagt agcagcataa atacttttgg agcaacatgg gcattagttt gttttccaaa gagacccata gtatttgata tctcttggct tgattccagc cccagtgata aaacactacc ttgtacttat ccattnnnnn ttctgcctgt gtttatactt tatgtaacct ttatatagtt agaagaatgc tactgctttt nnnnnnnnnn ctcctcatgg ttttaaactt ctatgctctg tcccaatgga tgagccaact gatactgtat nnnncttaaa ttgaaatatg tcctgtgttg taaggtgatt gaggttattg ataaacactc tacgtgccaa gtccagtgtt tctgaagaat taaatattgt atttgtatat agtaaccttt aattttgtat tagtttccca atcacatagc aggcaaga 980 ^ 7.cloc -420- 200533758 &lt; 210 &gt; 517 &lt; 211〉 416 &lt; 212〉 DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 41710 ^ at HG-U95Av2 &lt; 220> &lt; 221 &gt; misc__feature &lt; 222〉 (124) .. (145) Click &lt; 223〉 n is a, g, c or t

&lt;400〉 517 ccataattgt cacattccaa agaagnnnnn gtttctgttg agcaaaaact actatttgga ccagtacaga ttagccatgt ttttgaatag nnnnnnnnnn cactctgaaa aggtgtgtca aagagggtcc ataatttgta gagtttcagg ccagtgagca nnnnnatgct taaaatatgc ttgaaataat ttttaaaaac cttagtattt ttggtacacg atcaagtgta cttcctagta tttaaaaatg aggcataaaa tgaatttgta gcagcagggt ttcagacaga gagaaatgat gcttaatagg tagggaacag attaaatgtt ctaaatcaga ttgtctttgt actgctgtat aaatggccta ccacaagcta tgcttagaaa acataagaac tttgccatgt gaattc 60 120 180 240 300 360 416 &lt;210〉 518 &lt;211&gt; 383 &lt;212〉 DNA &lt;213〉人類 &lt;220〉 98677.doc 421 - 200533758 &lt;223〉 Probe 41735一at HG-U95Av2 &lt;220〉 &lt;221&gt; misc_ .feature &lt;222&gt; (70). .(141) &lt;223〉 n為 a，g，c 或 t&Lt; 400> 517 ccataattgt cacattccaa agaagnnnnn gtttctgttg agcaaaaact actatttgga ccagtacaga ttagccatgt ttttgaatag nnnnnnnnnn cactctgaaa aggtgtgtca aagagggtcc ataatttgta gagtttcagg ccagtgagca nnnnnatgct taaaatatgc ttgaaataat ttttaaaaac cttagtattt ttggtacacg atcaagtgta cttcctagta tttaaaaatg aggcataaaa tgaatttgta gcagcagggt ttcagacaga gagaaatgat gcttaatagg tagggaacag attaaatgtt ctaaatcaga ttgtctttgt actgctgtat aaatggccta ccacaagcta tgcttagaaa acataagaac tttgccatgt gaattc 60 120 180 240 300 360 416 &lt; 210〉 518 &lt; 211 &gt; 383 &lt; 212〉 DNA &lt; 213〉 Human &lt; 220〉 98677.doc 421-200533758 &lt; 223〉 Probe 41735-at HG-U95Av2 &lt; 220〉 &lt; 221 &gt; misc_ .feature &lt; 222 &gt; (70).. (141) &lt; 223> n is a, g, c or t

&lt;400〉 518 gctctacact atggtgtgcn nnnnnnnnnn ccaggtgtgg ctgcaacaag acaggaggca tgtgagcaca ccagggcatc nnnnnnnnnn nnnnnnnnnn gttggctcgg cagctcacag cccagcaacg ctgcaggtga ttgacccagc nnnnnnnnnn ncactgcaaa aagactccgt cccactgctc tgtactcgtg cca cgaaaaagtt nnnnnnnnnn agtgaactgc catctacatc cagtgtcacg cagcatggac gaagatgctc nnnnnnnnnn atggtgatgg atcaacgtcc gatttgattg ggcatggtgc accccaagtt nnnnnnnnnn ccgaccagaa acagcatgtc tgcaggacgg tggtgtggaa 60 120 180 240 300 360 383&Lt; 400> 518 gctctacact atggtgtgcn nnnnnnnnnn ccaggtgtgg ctgcaacaag acaggaggca tgtgagcaca ccagggcatc nnnnnnnnnn nnnnnnnnnn gttggctcgg cagctcacag cccagcaacg ctgcaggtga ttgacccagc nnnnnnnnnn ncactgcaaa aagactccgt cccactgctc tgtactcgtg cca cgaaaaagtt nnnnnnnnnn agtgaactgc catctacatc cagtgtcacg cagcatggac gaagatgctc nnnnnnnnnn atggtgatgg atcaacgtcc gatttgattg ggcatggtgc accccaagtt nnnnnnnnnn ccgaccagaa acagcatgtc tgcaggacgg tggtgtggaa 60 120 180 240 300 360 383

&lt;210〉 519 &lt;211&gt; 404 &lt;212〉 DNA &lt;213&gt; 人類 &lt;220〉 &lt;223&gt; Probe 41837_at HG-U95Av2 &lt;220&gt; &lt;221&gt; misc_feature &lt;222〉 61， 72, 78, 79, 82, 83, 98, 99， 101， 112·.114, 122， 124 &lt;223&gt; n 為 a，g，c 或 t &lt;220&gt; 98677.doc 422 -&lt; 210> 519 &lt; 211 &gt; 404 &lt; 212> DNA &lt; 213 &gt; human &lt; 220> &lt; 223 &gt; Probe 41837_at HG-U95Av2 &lt; 220 &gt; &lt; 221 &gt; misc_feature &lt; 222> 61, 72, 78, 79, 82, 83, 98, 99, 101, 112 · .114, 122, 124 &lt; 223 &gt; n is a, g, c or t &lt; 220 &gt; 98677.doc 422-

200533758 &lt;221&gt; misc_feature &lt;222&gt; 128, 131, 132, 141..143, 145..172, 174, 245..271 &lt;223〉n 為 a, g，c 或 t &lt;400〉 519 tcaccaatgc atatgaagag tatgcttggg gaagagctta ggaatggggt gggcatggga ntgctgggta gncagccnnt tnnagcaaat ctgcatcnnt nctcttattt cnnngacctt tntnccangt nncccagtcc nnntnnnnnn nnnnnnnnnn nnnnnnnnnn nntnctttat actatttaat cttttgcaga aaccttacta ttataacttg ctactctcca gataccaatt cttcnnnnnn nnnnnnnnnn nnnnnnnnnn ntgtcttact gatgttttca tgatcaactt gtaaatgtaa gcagttgact tcataaaagg tattttaact attcttggag tcctttgcta cccaagcacc tggtttcacc atgcgatcac tgacttctct acag &lt;210〉 520 &lt;211&gt; 415 &lt;212〉 DNA &lt;213&gt;人類 &lt;220&gt; &lt;223&gt; Probe 717_at HG-U95Av2 &lt;400〉 520 gttcggattt cgtggactct atgtgcagac ggagggcggc gactgcctgt agtatgtaaa tcttggatgc ttcacccttc atatgttttg tgttacttga tttatgcctg gtaaccagga tgaaatggtc atctgtgctt cgcaccagga gacaaggcgg ctgtttttgg cataatagtg gccctgtcct ccatggattt gtaggtgaca tgtggcatgt cacgttccca gcccttgat t 98677.doc -423 - 200533758 ctattttgct agatggtgct tggaggagga aatggaagat gtgtcaagaa gaggttggtg agaaaggaga ggaccttttt acatgcatgg gaaggttttt tttcccctct tggggatcta tttttttttt cccctatttt tggcctctgg aacattctga ttaagtacct tgctt200533758 &lt; 221 &gt; misc_feature &lt; 222 &gt; 128, 131, 132, 141..143, 145..172, 174, 245..271 &lt; 223〉 n is a, g, c or t &lt; 400〉 519 tcaccaatgc atatgaagag tatgcttggg gaagagctta ggaatggggt gggcatggga ntgctgggta gncagccnnt tnnagcaaat ctgcatcnnt nctcttattt cnnngacctt tntnccangt nncccagtcc nnntnnnnnn nnnnnnnnnn nnnnnnnnnn nntnctttat actatttaat cttttgcaga aaccttacta ttataacttg ctactctcca gataccaatt cttcnnnnnn nnnnnnnnnn nnnnnnnnnn ntgtcttact gatgttttca tgatcaactt gtaaatgtaa gcagttgact tcataaaagg tattttaact attcttggag tcctttgcta cccaagcacc tggtttcacc atgcgatcac tgacttctct acag &lt; 210> 520 &lt; 211 &gt; 415 &lt; 212> DNA &lt; 213 &gt; human &lt; 220 &gt; &lt; 223 &gt; Probe 717_at HG-U95Av2 &lt; 400> 520 gttcggattt cgtggactct atgtgcagac ggagggcggc gactgcctgt agtatgtaaa tcttggatgc ttcacccttc atatgttttg tgttacttga tttatgcctg gtaaccagga tgaaatggtc atctgtgctt cgcaccagga gacaaggcgg ctgtttttgg cataatagtg gccctgtcct ccatggattt gtaggtgaca tgtggcatgt cacgttccca gcccttgat t 98677.doc -423-20053 3758 ctattttgct agatggtgct tggaggagga aatggaagat gtgtcaagaa gaggttggtg agaaaggaga ggaccttttt acatgcatgg gaaggttttt tttcccctct tggggatcta tttttttttttt cccctatttt tggcctctgg atattcttga

98677.doc 424 -98677.doc 424-

Claims (1)

200533758 十、申請專利範圍： 1· 一種評估組織炎症反應的方法，包括·· 在試樣中進行至少5個在表丨巾出示 編碼之蛋白質之含量的定量判定；並 八 3猎此 與獲自對照組試樣之該轉錄本 斗&amp; 不+的含里比較如此判定之 该I*錄本或蛋白質的富含量。 2·如請求項1之方法，其中該試揭勺扛禮 L ^式樣包括獲自在患者中咸相 。又到、，且織炎症反應影響之部位的細胞。200533758 10. Scope of patent application: 1. A method for assessing tissue inflammatory response, including: Quantitatively determining the content of at least 5 proteins encoded on the surface of the sample in a sample; and The content of the transcript &amp; not + in the control sample was compared in this way to determine the rich content of the I * record or protein. 2. The method of claim 1, wherein the test pattern L ^ includes the salty phase obtained from the patient. Again, and weave cells at the site affected by the inflammatory response. 3. 項2之方法，其中該細胞為内皮細胞，且該試樣 為Μ者的血液、血清或尿。 4. 如請求項3之方法’纟中該内皮細胞是人類臍帶靜脈内 皮細胞、人_狀動脈内皮細胞或人類子諸 細胞。 反 5 ·如請求項1至4中任一頭夕古 ▲ 、方法，其中该對照組試樣係獲 得自該患者未受組織炎症反應影響之組織的内皮二 胞0 、、 6·如_U4中任一項之方法，其中該對照組試樣係獲 自在4患者中證實炎症反應是在較早之時間點的組織。 7·如請求項!至6中任一項之方法，其中該組織炎症反應涉 及下列的一或多個：白血球跨越内皮的移動、白血球移 ，至發炎的組織、白血球的激活作用、内皮細胞的激活 與血管生成，及/或抑制白血球或内皮細胞的細胞凋零。 女明求員1之方法，其為診斷與組織炎症反應有關之狀 況’或監視與組織炎症反應有關之狀況之進行的方法， %677.doc 200533758 且其業已診斷或監視與組織炎症反應有關之狀況的治療 效力。 9·如先前請求項中任一頁 貝之方法，其中該判定係在該患者 的治療過程之後進行。 10·如先前請求項中任一頂 一 r 貞之方法，其中判定至少10個在表 1中出不之轉錄本或藉此編碼之蛋白質的富含量。 月東員ίο之方法，其中判定至少2〇個在表工中出示之 轉錄本或藉此編碼之蛋白質的富含量。 12·如先前請求項中任一 ^ _ 、τ 1士項之方法，其中係藉著與基因晶片 陣列雜交來判定該富含量。 13·如請求項Ml中 Ύ 1 員之方法，其中係藉著定量PCR判 定該富含量。 14·種％斷與組織炎症反應有關之狀況的方法，包括在得 疑又這類狀況所苦之患者的試樣中，判定由至少5 個表1之轉錄本編碼的内皮細胞-衍生之蛋白質的富含 量° 15 ·如先前請求項中 炎症、員中任一項之方法，其中該組織炎症反應與 ^ ;疾病血官徵候群、動脈粥樣硬化或相關疾病、 r又:生移植排斥或其中涉及腫瘤生長的狀況有關。 1 6 ·如請求項1 5 广 、 万法’其中該炎症性疾病包括炎症性腸 ，皮癬、局部缺血的再灌注、成人呼吸緊迫徵候 /I、氣而、過敏性鼻炎、皮膚炎、腦膜炎、腦炎、葡萄 膜炎、涉；5 &amp; 1 血球渗出的疾病、中枢神經系統炎症性病 症阿絲海默氏症、子宮内膜異位症、多發性硬化症、 98677.doc 200533758 $器官傷害徵候群、酒精性肝炎、細菌性肺炎、抗原-抗 ，複合物調解之疾病；肺臟的炎症（包括胸膜炎、肺泡 人肺火、^性支氣管炎、支氣管擴張、胰囊性纖維變 性和⑶PD)、血管炎、結節性多動脈炎、巨細胞動脈 17 18. 人』U鏡下多動脈炎、子瘤前症和自體免疫疾病。 •:先刖明求項中任一項之方法，其中該比較在該試樣與 該對照組試樣之間，判定在轉錄本含量或轉錄本富含量 之模式上的變化。 如先刖睛求項中任一項之方法，丨中所判定之含量/富含 =係屬於至少-個選自下列的轉錄本或藉此編碼之蛋白 貝的菌，各刺激因子3(粒性細胞）、菌落刺激因子2(粒性 細胞-巨噬細胞）、粒性細胞化學吸引蛋白質2、二泛素、 ELAM 1、TNF-誘導之蛋白質 6、Exodus 1、IL-1/5、 VCAM_1、ICAM」、IApi、TNF 可誘導之 a2〇、 RIPK2、MMP l〇、TRAF1、JAK結合蛋白質、雙重專一 (1 % 酉文酶 4、il-6、IL-8、Gro-γ、MCP-1、Gro-/3、Gro_ a ENA_78、趨化因數、小的可誘導之細胞激動素亞家 族A14、小的可誘導之細胞激動素A5、LI7受體、類鐸/ 介白素 1 受體 4、CCAAT、MAD-3、COX-2、Mn SOD、 NO合成酶、L_犬尿胺酸水解酶、組織因子路徑抑制劑 2、昆布胺酸γ2、類-鐸受體2、天然殺手細胞轉錄本4、 TNF-α誘導之蛋白質2、陽離子胺基酸運載者2Α、脂肪酸 結合蛋白質4、TNF受體超級家族成員lib和TNF超級家 族成員9。 98677.doc 200533758 19.如請求項18之方法，其中該轉錄本或藉此編碼之蛋白質 係選自：菌落刺激因子3(粒性細胞）、菌落刺激因子2(粒 性細胞-巨噬細胞）、粒性細胞化學吸引蛋白質2、二泛 素、ELAM]、TNF-誘導之蛋白質 6、Ex〇dus 2〇· 一種適合用在如請求項1至19中任一項之方法中之基因 晶片陣列，包括至少5個適合用來檢測至少5個在表i中 出不之轉錄本的核酸；可視需要還有對該轉錄本專一的 對照組；並可視需要還有至少一個該基因晶片的對照 、组。 &lt;、、 22. 21. —種用來檢測至少5個在表丨中出示之轉錄本之基因晶片 陣列，包括至少5個選自表2的核酸，能夠檢測^亥至曰曰少5 個轉錄本的存在；可視需要還有對該轉錄本專一的對日刀 組；並可視需要還有至少一個該基因晶片的對照組。&quot; :種適合用在如請求項中任一項之方法之 質為基礎之陣列’以便評估至少5個由包括在表 ίΓ的轉錄本編碼的蛋白質，可視需要還有對該^ 貝專一的對照組；並可韻兩 资白 照組。 m要㈣至少—個該測定的對 23.如請求項22之陣列，其為eusa或抗體晶片。 认一種用來判定組織炎症反應或舆其有關狀況 劑的測定方法，包括·· 揚凋節 a) 提供由得自表1之轉錄本編碼的蛋白質； b) 使该蛋白質與其活性之候選㈣揚㈣劑接觸； 98677.doc 200533758 〇判定該候選的抑揚調節劑是否能夠調節該蛋白質之活 性0 25.如請求項24之測定方法，豆中該 ^ χ该通的抑％調節劑是與 口亥蛋白貝結合的抗體或其結合片段。 26·如請求項24之測定方法，豆中兮 /、 候&amp;的抑揚調節劑是該 蛋白質之片段或其模仿物。 27. —種測定組織炎症反應或 “ X-、/、喇關之狀況的抑揚調節劑 的方法，其中該方法包括： a) 提供培養中的内皮細胞； b) 使该細胞與該狀況之候選的抑揚調節劑接觸；並 C)判定該候選的抑揚調節劑是否能夠調節至少一個表工 之轉錄本的含量。 其中該候選的抑揚調節劑是反 其中该候選的抑揚調節劑是反 28·如請求項27之測定方法 義寡核苷酸或RNAi。 29·如請求項27之測定方法 義募核芽酸。 30. —種根據如請求項24至29中任一項之測定方法獲得的抑 揚調節劑之用途，係治療組織炎症反應或與其有關之狀 況。 3 1 · —種包括編碼得自表ib之轉錄本的序列的載體，其以可 操作之方式與轉錄該序列的啟動基因連接。 32.如請求項3丨之載體，其中該序列在架構中與轉譯該序列 的轉譯開始區域連接。 33·如請求項31之載體，其中該序列為反義方位。 98677.doc 200533758 七、指定代表圖： (一) 本案指定代表圖為：（無） (二) 本代表圖之元件符號簡單說明·· 八、本案若有化學式時，請揭示最能顯示發明特徵的化學式： (無）3. The method of item 2, wherein the cell is an endothelial cell, and the sample is blood, serum, or urine of a person with M. 4. The method of claim 3, wherein the endothelial cells are human umbilical vein endothelial cells, human arterial endothelial cells, or human daughter cells. Inverse 5 · As in any one of the claims 1 to 4, the method, wherein the control sample is obtained from endothelial cells 2 of the patient's tissue that is not affected by the tissue inflammation reaction, such as in _U4 The method according to any one of the preceding claims, wherein the control sample is obtained from tissues in which the inflammatory response was confirmed at an earlier time point in 4 patients. 7. The method of any one of claims! To 6, wherein the tissue inflammatory response involves one or more of the following: movement of white blood cells across the endothelium, movement of white blood cells, to inflamed tissue, activation of white blood cells, endothelial cells Activates and angiogenesis, and / or inhibits the decay of white blood cells or endothelial cells. The method of Numing Seeker 1 is a method for diagnosing a condition related to a tissue inflammatory response 'or monitoring a condition related to a tissue inflammatory response,% 677.doc 200533758, and it has been diagnosed or monitored for a tissue inflammatory response The therapeutic efficacy of the condition. 9. The method of any of the previous claims, wherein the determination is made after the patient's course of treatment. 10. The method according to any one of the preceding claims, wherein the rich content of at least 10 transcripts or proteins encoded thereby is determined. Yuedong's method, in which the rich content of at least 20 transcripts or proteins encoded by the watchmaker is determined. 12. The method as described in any one of the previous claims, wherein the rich content is determined by hybridization with a gene chip array. 13. The method according to claim 1 in claim M1, wherein the rich content is determined by quantitative PCR. 14. A method for determining a condition related to a tissue inflammatory response, including determining an endothelial cell-derived protein encoded by at least 5 of the transcripts of Table 1 in a sample of a patient suspected of suffering from such a condition The rich content of ° 15 · The method as in any one of the previous claims, wherein the inflammation of the tissue is related to ^; disease hemorrhagic syndrome, atherosclerosis or related diseases, and: transplant rejection Or the conditions involved in tumor growth. 1 6 · As requested in item 1 5 and 5 of the method, wherein the inflammatory diseases include inflammatory bowel, dermatitis, ischemic reperfusion, adult respiratory signs / I, qi, allergic rhinitis, dermatitis, Meningitis, encephalitis, uveitis, and related; 5 &amp; 1 diseases of exuding blood cells, inflammatory disorders of the central nervous system, Alzheimer's disease, endometriosis, multiple sclerosis, 98677.doc 200533758 $ Symptoms of organ injury, alcoholic hepatitis, bacterial pneumonia, antigen-resistant, complex-mediated diseases; inflammation of the lungs (including pleurisy, alveolar lung fire, bronchiolitis, bronchiectasis, pancreatic cystic fibrosis And CDPD), vasculitis, nodular polyarteritis, giant cell arteries17. Human polyarteritis, premalignant disease, and autoimmune diseases under microscope. •: The method of any one of the preceding terms, in which the comparison between the sample and the control sample determines the change in the pattern of transcript content or transcript-rich content. As described in the method of any one of the above items, the content / enrichment determined in 丨 is a bacterium belonging to at least one selected from the following transcripts or protein shellfish encoded thereby, each stimulating factor 3 (granule) Cells), colony-stimulating factor 2 (granulocytes-macrophages), granulocytes chemically attract protein 2, diubiquitin, ELAM 1, TNF-induced protein 6, Exodus 1, IL-1 / 5, VCAM_1 ", ICAM", IApi, TNF-inducible a2O, RIPK2, MMP 10, TRAF1, JAK-binding protein, dual specificity (1% zymase 4, il-6, IL-8, Gro-γ, MCP-1 , Gro- / 3, Gro_ a ENA_78, chemokine, small inducible cytokinin subfamily A14, small inducible cytokinin A5, LI7 receptor, dorsoid / interleukin 1 receptor 4 , CCAAT, MAD-3, COX-2, Mn SOD, NO synthetase, L_kynurenine hydrolase, tissue factor pathway inhibitor 2, cuminic acid γ2, reid-like receptor 2, natural killer cell transcription Ben 4, TNF-α-induced protein 2, cationic amino acid carrier 2A, fatty acid binding protein 4, TNF receptor super family member lib and TNF super family Member 9. 98677.doc 200533758 19. The method of claim 18, wherein the transcript or the protein encoded thereby is selected from the group consisting of: colony-stimulating factor 3 (granulocyte), colony-stimulating factor 2 (granulocyte-macro Phagocytosis), granulocyte cytochemically attracted protein 2, diubiquitin, ELAM], TNF-induced protein 6, Ex〇dus 2〇. A method suitable for use in any one of claims 1 to 19 Gene chip array, including at least 5 nucleic acids suitable for detecting at least 5 transcripts that are not listed in Table i; a control group specific to the transcript may be optionally provided; and at least one gene chip may be optionally provided &Lt; ,,, 22. 21. A genetic chip array for detecting at least 5 transcripts shown in Table 丨, including at least 5 nucleic acids selected from Table 2, capable of detecting The existence of at least 5 transcripts; if necessary, a sun-knife group specific to the transcript; and at least one control group for the gene chip, if necessary. &Quot;: A species suitable for use in, for example, a request Based on the quality of either method Columns' in order to evaluate at least 5 proteins encoded by the transcripts included in Table Γ, and a control group specific to this group if necessary; and a two-in-one group of white photos. M m㈣ At least one of this assay For 23. The array as claimed in item 22, which is an eusa or antibody wafer. A method for determining the inflammatory response of a tissue or its related condition agents, including the Yangtze Festival a) provided by Table 1 Transcript-encoded protein; b) contacting the protein with its active candidate liniment; 98677.doc 200533758; determining whether the candidate inhibitory modulator can modulate the activity of the protein 0 25. As described in the method of claim 24 The% inhibitory agent in beans is an antibody or a binding fragment thereof that binds to protein. 26. The method of measurement according to claim 24, wherein the suppressor of yin and hou is a fragment of the protein or a mimetic thereof. 27. A method for measuring a inflammatory response or a suppressor condition of a condition of "X-, /, Laguan", wherein the method includes: a) providing endothelial cells in culture; b) associating the cells with the condition candidates And C) determine whether the candidate anti-modulator can regulate the content of at least one epitope transcript. Wherein the candidate anti-modulator is anti-inhibitor and the candidate anti-modulator is anti-28. Such as The method of claim 27 for a sense oligonucleotide or RNAi. 29. The method of claim 27 for a method for raising riboic acid. 30.-A method obtained by the method of any one of claims 24 to 29 The use of a modulator is to treat a tissue inflammatory response or a condition related to it. 31. A vector comprising a sequence encoding a transcript obtained from Table ib, which is operatively linked to a promoter gene that transcribes the sequence. 32. The vector of claim 3, wherein the sequence is connected in the architecture to a translation start region where the sequence is translated. 33. The vector of claim 31, wherein the sequence is an antisense orientation. 986 77.doc 200533758 VII. Designated representative map: (1) The designated representative map of this case is: (none) (II) Simple explanation of the component symbols of this representative map. 8. If there is a chemical formula in this case, please disclose the features that best show the invention Chemical formula: (none) 98677.doc98677.doc
TW094101217A 2004-01-16 2005-01-14 Methods of diagnosis TW200533758A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0400976.7A GB0400976D0 (en) 2004-01-16 2004-01-16 Methods of diagnosis

Publications (1)

Publication Number Publication Date
TW200533758A true TW200533758A (en) 2005-10-16

Family

ID=31726300

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094101217A TW200533758A (en) 2004-01-16 2005-01-14 Methods of diagnosis

Country Status (10)

Country Link
EP (1) EP1711630A2 (en)
JP (1) JP2007522800A (en)
KR (1) KR20060122927A (en)
CN (1) CN1934274A (en)
AU (1) AU2005205218A1 (en)
CA (1) CA2551677A1 (en)
GB (2) GB0400976D0 (en)
RU (1) RU2006129631A (en)
TW (1) TW200533758A (en)
WO (1) WO2005068655A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943328B1 (en) 2006-03-03 2011-05-17 Prometheus Laboratories Inc. Method and system for assisting in diagnosing irritable bowel syndrome
DE102006027842B4 (en) * 2006-06-16 2014-07-31 Analytik Jena Ag Method for determining the source of infection in fever of uncertain origin
US20080085524A1 (en) 2006-08-15 2008-04-10 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
US20100113286A1 (en) * 2007-05-05 2010-05-06 Gilles Andre Lajoie Methods for detection of preeclampsia
ES2657969T3 (en) * 2010-04-02 2018-03-07 Curna, Inc. Treatment of diseases related to Colony Stimulating Factor 3 (CSF3) by inhibition of the natural antisense transcript to CSF3
DK3147373T3 (en) 2010-07-27 2019-08-12 Genomic Health Inc METHOD OF APPLYING GENEPRESSION TO DETERMINE THE PROSTATE CANCER FORECAST
CN102766679B (en) * 2011-05-04 2015-02-25 上海人类基因组研究中心 Detection method, probe set, and diagnostic kit for predicting postoperation recurrence-free survival of colorectal cancer via gene expression states of two probes
EP2799878A1 (en) * 2013-05-03 2014-11-05 SALION GmbH In vitro method for the early detection of a potential inflammation, in particular associated with rejection of a transplant using kynurenine as a marker.
SI3193901T1 (en) * 2014-12-23 2018-06-29 4D Pharma Research Limited Pirin polypeptide and immune modulation
CN107328941A (en) * 2017-06-24 2017-11-07 梧州市兴能农业科技有限公司 It is a kind of to detect the antibody chip of various kinds of cell adhesion factor simultaneously
CN114452286A (en) * 2021-07-23 2022-05-10 上海交通大学医学院附属新华医院 RAL inhibitors for the prevention and treatment of osteoarthritis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307025B1 (en) * 1989-04-28 2001-10-23 Biogen, Inc. VCAM fusion proteins and DNA coding therefor
US20030036070A1 (en) * 1999-10-21 2003-02-20 Shukti Chakravarti Gene expression profiling of inflammatory bowel disease
AU1159601A (en) * 1999-11-03 2001-05-14 Metris Therapeutics Limited Agents implicated in endometriosis
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
EP1319717A1 (en) * 2001-12-11 2003-06-18 Roche Diagnostics GmbH Method for detection of inflammatory processes

Also Published As

Publication number Publication date
GB0615106D0 (en) 2006-09-06
CA2551677A1 (en) 2005-07-28
WO2005068655A3 (en) 2005-11-17
EP1711630A2 (en) 2006-10-18
CN1934274A (en) 2007-03-21
JP2007522800A (en) 2007-08-16
KR20060122927A (en) 2006-11-30
GB0400976D0 (en) 2004-02-18
AU2005205218A1 (en) 2005-07-28
WO2005068655A2 (en) 2005-07-28
RU2006129631A (en) 2008-02-27
GB2424947A (en) 2006-10-11

Similar Documents

Publication Publication Date Title
AU2017267184B2 (en) Method for assessing a prognosis and predicting the response of patients with malignant diseases to immunotherapy
DK2644711T3 (en) A method for diagnosing neoplasms
TW200533758A (en) Methods of diagnosis
CN107077536B (en) Evaluation of activity of TGF-beta cell signaling pathway using mathematical modeling of target gene expression
KR102114412B1 (en) PREDICTING GASTROENTEROPANCREATIC NEUROENDOCRINE NEOPLASMS (GEP-NENs)
CN107255721A (en) Mark is used for the purposes for recognizing cardiac toxic agents
KR101421326B1 (en) Composition for predicting prognosis of breast cancer and kit comprising the same
CN101258249A (en) Methods and reagents for the detection of melanoma
AU779411B2 (en) Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism
CN101573453A (en) Methods of predicting distant metastasis of lymph node-negative primary breast cancer using biological pathway gene expression analysis
KR20140140069A (en) Compositions and methods for diagnosis and treatment of pervasive developmental disorder
CA2403946A1 (en) Genes expressed in foam cell differentiation
JP2003304888A (en) Method for toxicity prediction of compound
IL215618A (en) Predictive models and method for assessing age
KR20160059446A (en) Cancer panel for identification of genomic variations in cancer
CN114127314A (en) Genetic genomes, methods and kits for identifying or classifying subtypes (subtypes) of breast cancer
KR20110073451A (en) Interferon response in clinical samples (iris)
US20020137077A1 (en) Genes regulated in activated T cells
JP2003259877A (en) Marker for hepatic fibrosis disease and application of the same
AU784761B2 (en) Biallelic markers related to genes involved in drug metabolism
US20030175761A1 (en) Identification of genes whose expression patterns distinguish benign lymphoid tissue and mantle cell, follicular, and small lymphocytic lymphoma
CN100516876C (en) Methods for diagnosing RCC and other solid tumors
US20030175704A1 (en) Genes expressed in lung cancer
KR101634047B1 (en) Biomarkers for detection of ADHD
KR101633998B1 (en) Biomarkers for detection of ADHD