TW200505946A - Process for preparation of cyclosporin a analog - Google Patents

Process for preparation of cyclosporin a analog

Info

Publication number: TW200505946A
Authority: TW; Taiwan
Prior art keywords: cyclosporin; analog; preparation; formula; allylmetal
Prior art date: 2003-04-08

Application number

TW093108938A

Other languages

English (en)

Inventor

Jean-Michel Adam

Mark Abel

Seetharaman Jayaraman

Original Assignee

Hoffmann La Roche

Isotechnika Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-08

Filing date

2004-03-31

Publication date

2005-02-16

2004-03-31 Application filed by Hoffmann La Roche, Isotechnika Inc filed Critical Hoffmann La Roche

2005-02-16 Publication of TW200505946A publication Critical patent/TW200505946A/zh

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 cyclosporin A aldehyde Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Veterinary Medicine (AREA)
Transplantation (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

TW093108938A 2003-04-08 2004-03-31 Process for preparation of cyclosporin a analog TW200505946A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03007921		2003-04-08

Publications (1)

Publication Number	Publication Date
TW200505946A true TW200505946A (en)	2005-02-16

Family

ID=33155122

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW093108938A TW200505946A (en)	2003-04-08	2004-03-31	Process for preparation of cyclosporin a analog

Country Status (18)

Country	Link
US (1)	US20040220091A1 (zh)
EP (1)	EP1613646A2 (zh)
JP (1)	JP2006525961A (zh)
KR (1)	KR20050119200A (zh)
CN (1)	CN1798759A (zh)
AU (1)	AU2004228159A1 (zh)
BR (1)	BRPI0409734A (zh)
CA (1)	CA2521116A1 (zh)
CO (1)	CO5680450A2 (zh)
EC (1)	ECSP056091A (zh)
MA (1)	MA27831A1 (zh)
MX (1)	MXPA05010794A (zh)
NO (1)	NO20054478L (zh)
RU (1)	RU2005130508A (zh)
TN (1)	TNSN05255A1 (zh)
TW (1)	TW200505946A (zh)
WO (1)	WO2004089960A2 (zh)
ZA (1)	ZA200507980B (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6859799B1 (en)	1998-11-30	2005-02-22	Gemstar Development Corporation	Search engine for video and graphics
US7103906B1 (en)	2000-09-29	2006-09-05	International Business Machines Corporation	User controlled multi-device media-on-demand system
CN100397899C (zh)	2000-10-11	2008-06-25	联合视频制品公司	提供数据存储到点播媒体传递*中服务器上的*和方法
US7493646B2 (en)	2003-01-30	2009-02-17	United Video Properties, Inc.	Interactive television systems with digital video recording and adjustable reminders
AU2004222306A1 (en) *	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Novel cyclosporins
WO2006014872A2 (en) *	2004-07-29	2006-02-09	Amr Technology, Inc.	Novel processes for stereoselective synthesis of trans isatx 247
US8086575B2 (en)	2004-09-23	2011-12-27	Rovi Solutions Corporation	Methods and apparatus for integrating disparate media formats in a networked media system
JP2008514702A (ja) *	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
US7378391B2 (en) *	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008515886A (ja) *	2004-10-06	2008-05-15	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
KR100780718B1 (ko)	2004-12-28	2007-12-26	엘지.필립스 엘시디 주식회사	도포액 공급장치를 구비한 슬릿코터
US9681105B2 (en)	2005-12-29	2017-06-13	Rovi Guides, Inc.	Interactive media guidance system having multiple devices
US8607287B2 (en)	2005-12-29	2013-12-10	United Video Properties, Inc.	Interactive media guidance system having multiple devices
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US20090019492A1 (en)	2007-07-11	2009-01-15	United Video Properties, Inc.	Systems and methods for mirroring and transcoding media content
EP2197461B1 (en)	2007-10-08	2018-02-21	Aurinia Pharmaceuticals Inc.	Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors
US8601526B2 (en)	2008-06-13	2013-12-03	United Video Properties, Inc.	Systems and methods for displaying media content and media guidance information
FR2934997B1 (fr) *	2008-08-14	2010-09-24	Minakem	Derives cyclopropyl-et cyclobutyl-dioxazaborocanes ou dioxazaborecanes
US9017725B2 (en)	2009-06-09	2015-04-28	Aurinia Pharmaceuticals Inc.	Topical drug delivery systems for ophthalmic use
US9014546B2 (en)	2009-09-23	2015-04-21	Rovi Guides, Inc.	Systems and methods for automatically detecting users within detection regions of media devices
AU2011342284C1 (en)	2010-12-15	2017-07-13	Contravir Pharmaceuticals, Inc.	Cyclosporine analogue molecules modified at amino acid 1 and 3
US8805418B2 (en)	2011-12-23	2014-08-12	United Video Properties, Inc.	Methods and systems for performing actions based on location-based rules
AR090964A1 (es)	2012-05-09	2014-12-17	Novartis Ag	Proceso para la elaboracion de undecapeptidos ciclicos
US9674563B2 (en)	2013-11-04	2017-06-06	Rovi Guides, Inc.	Systems and methods for recommending content
US20190224275A1 (en)	2017-05-12	2019-07-25	Aurinia Pharmaceuticals Inc.	Protocol for treatment of lupus nephritis
EP4201952A1 (en)	2021-12-21	2023-06-28	Curia Spain, S.A.U.	Process for the controlled synthesis of voclosporin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE95193T1 (de) *	1987-06-17	1993-10-15	Sandoz Ag	Cyclosporine und deren benutzung als arzneimittel.
AU7267298A (en) *	1997-04-30	1998-11-24	Regents Of The University Of California, The	Synthesis of discodermolide and analogs
NZ502362A (en) *	1997-10-08	2001-05-25	Isotechnika Inc	Deuterated cyclosporine A derivatives and their use as immunomodulating agents
DE10143979A1 (de) *	2001-09-07	2003-03-27	Clariant Gmbh	Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
EP1816138A1 (en) *	2001-10-19	2007-08-08	Isotechnika,Inc.	Cyclosporine analogue mixtures and their use as immunomodulating agents
WO2003033526A2 (en) *	2001-10-19	2003-04-24	Isotechnika Inc.	Synthesis of cyclosporin analogs

2004
- 2004-03-31 TW TW093108938A patent/TW200505946A/zh unknown
- 2004-04-02 KR KR1020057019162A patent/KR20050119200A/ko not_active Application Discontinuation
- 2004-04-02 BR BRPI0409734-3A patent/BRPI0409734A/pt not_active Application Discontinuation
- 2004-04-02 RU RU2005130508/04A patent/RU2005130508A/ru not_active Application Discontinuation
- 2004-04-02 AU AU2004228159A patent/AU2004228159A1/en not_active Abandoned
- 2004-04-02 CA CA002521116A patent/CA2521116A1/en not_active Abandoned
- 2004-04-02 EP EP04725333A patent/EP1613646A2/en not_active Withdrawn
- 2004-04-02 CN CNA2004800154235A patent/CN1798759A/zh active Pending
- 2004-04-02 MX MXPA05010794A patent/MXPA05010794A/es unknown
- 2004-04-02 WO PCT/EP2004/003504 patent/WO2004089960A2/en not_active Application Discontinuation
- 2004-04-02 JP JP2006504961A patent/JP2006525961A/ja not_active Withdrawn
- 2004-04-02 ZA ZA200507980A patent/ZA200507980B/en unknown
- 2004-04-05 US US10/817,991 patent/US20040220091A1/en not_active Abandoned
2005
- 2005-09-28 NO NO20054478A patent/NO20054478L/no not_active Application Discontinuation
- 2005-10-06 CO CO05101444A patent/CO5680450A2/es not_active Application Discontinuation
- 2005-10-07 TN TNP2005000255A patent/TNSN05255A1/en unknown
- 2005-10-07 MA MA28540A patent/MA27831A1/fr unknown
- 2005-10-07 EC EC2005006091A patent/ECSP056091A/es unknown

Also Published As

Publication number	Publication date
NO20054478D0 (no)	2005-09-28
MA27831A1 (fr)	2006-04-03
NO20054478L (no)	2005-10-17
WO2004089960A3 (en)	2005-01-06
KR20050119200A (ko)	2005-12-20
AU2004228159A1 (en)	2004-10-21
CN1798759A (zh)	2006-07-05
BRPI0409734A (pt)	2006-05-09
MXPA05010794A (es)	2005-12-14
WO2004089960A2 (en)	2004-10-21
US20040220091A1 (en)	2004-11-04
JP2006525961A (ja)	2006-11-16
ZA200507980B (en)	2006-11-29
ECSP056091A (es)	2006-03-01
RU2005130508A (ru)	2006-06-27
EP1613646A2 (en)	2006-01-11
CA2521116A1 (en)	2004-10-21
TNSN05255A1 (en)	2007-07-10
CO5680450A2 (es)	2006-09-29

Publication	Publication Date	Title
TW200505946A (en)	2005-02-16	Process for preparation of cyclosporin a analog
HK1205129A1 (zh)	2015-12-11	鐵有機化合物、其應用及其製備方法
TNSN07235A1 (en)	2008-11-21	Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
TW200511444A (en)	2005-03-16	Strained-silicon-on-insulator single-and double-gate MOSFET and method for forming the same
MX2007005408A (es)	2007-05-16	Compuestos de aminoquinazolinas.
TW200510325A (en)	2005-03-16	2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
DE502005008057D1 (de)	2009-10-15	Substituierte cyclopenten-verbindungen
TW200614994A (en)	2006-05-16	Mycophenolate mofetil impurity
EA200700673A1 (ru)	2007-10-26	Твердая фармацевтическая композиция, содержащая донепезила гидрохлорид
GEP20084361B (en)	2008-04-29	Piperidinylcarbonyl-pyrro-lidines and their use as melanocortin agonists
GR1004074B (el)	2002-11-26	Μεθοδος παρασκευης της σιταλοπραμης.
GEP20084454B (en)	2008-08-10	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates
MX2009004343A (es)	2009-05-05	Compuestos organicos.
TW200612959A (en)	2006-05-01	Method for preparing hydroxamic acids
MXPA05013758A (es)	2006-03-13	Composiciones farmaceuticas que incluyen una antihistamina y un estimulante y uso de las mismas.
TW200613308A (en)	2006-05-01	Cyclobutanetetracarboxylate compound and preparation method thereof
WO2004030664A3 (en)	2004-08-12	New compounds for the inhibition of undesired cell proliferation and use thereof
GB0212410D0 (en)	2002-07-10	Organic compounds
RS20060206A (en)	2008-08-07	Aminopyridine-derivatives as inducible no-synthase inhibitors
GB0000888D0 (en)	2000-03-08	Compound
DE60233064D1 (de)	2009-09-03	Analgetisches antitumorpeptid aus skorpionen und verfahren zu dessen herstellung
MXPA04004090A (es)	2004-07-08	Compuestos substituidos de 1h-quinolin-2-ona.
RS20060196A (en)	2008-08-07	Imidazopyridine-derivatives as inducible no-synthase inhibitors
WO2006045120A3 (en)	2006-08-10	Purification of tegaserod maleate
WO2005054175A3 (en)	2006-11-30	New process for the preparation of nitrooxyderivatives of paracetamol