TR2024001758A2 - DRY DIALIZATE PREPARATION, DISTRIBUTION, DOSING SYSTEM AND CONSUMABLES - Google Patents
DRY DIALIZATE PREPARATION, DISTRIBUTION, DOSING SYSTEM AND CONSUMABLESInfo
- Publication number
- TR2024001758A2 TR2024001758A2 TR2024/001758 TR2024001758A2 TR 2024001758 A2 TR2024001758 A2 TR 2024001758A2 TR 2024/001758 TR2024/001758 TR 2024/001758 TR 2024001758 A2 TR2024001758 A2 TR 2024001758A2
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- Prior art keywords
- solution
- tank
- acidic solution
- basic
- acidic
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 28
- 238000009826 distribution Methods 0.000 title description 13
- 238000000502 dialysis Methods 0.000 claims abstract description 51
- 239000000203 mixture Substances 0.000 claims abstract description 31
- 239000003929 acidic solution Substances 0.000 claims description 309
- 239000003637 basic solution Substances 0.000 claims description 276
- 239000000243 solution Substances 0.000 claims description 179
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 108
- 238000002156 mixing Methods 0.000 claims description 89
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 76
- 229910001868 water Inorganic materials 0.000 claims description 76
- 238000005406 washing Methods 0.000 claims description 47
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 41
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 37
- 239000008103 glucose Substances 0.000 claims description 37
- 239000000126 substance Substances 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 21
- 238000005086 pumping Methods 0.000 claims description 17
- 230000002572 peristaltic effect Effects 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 13
- 239000002699 waste material Substances 0.000 claims description 11
- 239000000385 dialysis solution Substances 0.000 claims description 8
- 239000012670 alkaline solution Substances 0.000 claims 1
- 239000013013 elastic material Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 32
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 14
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 12
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 11
- 239000011591 potassium Substances 0.000 description 11
- 229910052700 potassium Inorganic materials 0.000 description 11
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 10
- 239000011777 magnesium Substances 0.000 description 10
- 229910052749 magnesium Inorganic materials 0.000 description 10
- 239000012528 membrane Substances 0.000 description 10
- 238000004806 packaging method and process Methods 0.000 description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 9
- 239000011575 calcium Substances 0.000 description 9
- 229910052791 calcium Inorganic materials 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 238000010586 diagram Methods 0.000 description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000000155 melt Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 238000001631 haemodialysis Methods 0.000 description 3
- 230000000322 hemodialysis Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000011017 operating method Methods 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Abstract
Buluş; Kronik böbrek yetmezliği olan hastaların tedavi metodu olan, diyaliz tedavisinde kullanılmak üzere diyalizat solusyonlarını, hazırlanması ve hastanın ihtiyacına göre terkibini değiştirerek, diyaliz makinelerine servis etmeye yarayan Cihazlar ve sarf malzemelerinden oluşan sistemdir.Meet; It is a system consisting of devices and consumables used to prepare dialysate solutions to be used in dialysis treatment, which is the treatment method of patients with chronic renal failure, and to serve them to dialysis machines by changing their composition according to the patient's needs.
Description
TARIFNAME KURU DIYALIZAT HAZIRLAMA, DAGITIM, DOSAJLAMA SISTEMI VE SARF MALZEMELERI Teknigin bilinen durumu; Diyalizat solüsyonu; filtrasyon esasi ile yapilan hemodiyaliz isleminde, diyalizör membraninin retantate kompaitmaninda diyaliz neticesinde hedeflenen konsantrasyona haiz dengeleme solüsyonü olarak kullanilir. Hemodiyaliz tedavisinde, hasta kani diyaliz makinesi marifeti ile diyalizör adli filtrenin permeate kismindan geçirilir. Diyalizör yari geçirgen bir membrana sahiptir. Membran, hollow fiber formunda borucuklar seklinde olup, diyalizörde bu borucuklardan 5.000 ila .000 arasinda degisen sayida borucuk bulunur. Diyalizör membraninin toplam yüzey alani 0,7 ila 2,2 metrekare arasindadir. Sekil 1 de gösterilen Diyaliz tedavisi akis semasi ile; Hastadan alinan Kan; Diyalizörün (8) Kan girisinden (6) girer membran borucuklarinin içinden geçer ve Kan çikisindan (7) çikarak hastaya geri verilir. Diyaliz islemi sirasinda kan ile membran duvari disindaki diyalizat sivisi arasinda iyon alis verisi olur. Diyaliz islemi ile kan içinde birikmis metobolik artiklar ve vucutta birikmis olan su diyalizör membranindan geçerek diyalizat solusyonundaki madde miktarlari ile esitlenir. Diyalizat solusyonunda bulunan maddeler ile kanda bulunan; su, sodyum, potasyum, kalsiyum, magnezyum gibi maddelerin tamamen atilmasi engellenir ve bu maddelerin kandaki miktari, kanda bulunmasi gereken normal degerlerine indirilir. Diyaliz islemi ile kanda biriken suyun fazlasi, tuzlar ve metabolizma artigi olan üre kreatinin gibi maddeler membran duvarindan geçerek atilir, sekilli elemanlar, proteinler ve hücreler membran duvarindan geçemedigi için kanda kalir. Hemodiyaliz tedavisinde kullanilan diyalizat solusyonlari; Asidik solüsyon (2) ve Bazik solüsyon (3) olarak iki ayri formda ve konsantre solusyon olarak hazirlanir. Her iki solüsyon Diyaliz makinesinde (9) Saf su (1) ile seyreltilir ve karistirilir. Hazirlanan karisim Diyalizörün (8) Diyalizat girisinden (4) pompalanip diyaliz membranlarini distan yikar. Daha sonra Diyalizörün (8) Diyalizat çikisindan (5) çikar ve atilir. Asidik solüsyon (2); Sodyum klorür, Potasyum klorür, Kalsiyum klorür, Magnezyum klorür, Glikoz ve Asetik asitin karisimi ile hazirlanir. Asidik solusyonün (2) içerigi hastanin ihtiyacina bagli olarak farklilik arz eder. Diyalizat sivisindaki Potasyum 1 ila 3 mmol/lt, Kalsiyum 1 ila 2 mmol/lt Magnezyum 0.25 ila 1 mmol/lt araliginda olacak sekilde veya degisik degerlerde konsantre solusyon olarak hazirlanir. Bazik solüsyon (3) Sodyum bikarbonattan olusmaktadir. Diyalizat sivisindaki Bikarbonat degeri 32 mmol/lt olacak sekilde veya degisik degerlerde konsantre solusyon olarak hazirlanir. Konsantre solusyon olarak hazirlanan diyalizat solüsyonlarini, diyaliz makinesinde 1/35, 1/45 veya farkli oranlarda seyrelterek kullanir. Solüsyonun "Konsantre" hazirlanmasinin sebebi ambalaj ve nakliye maliyetini düsürmektir. Diyaliz islemi tüm dünyada kahir ekseriyette diyaliz merkezlerinde yapilir. Diyalizat solüsyonlari üç farkli ambalajlama formunda üretilip diyaliz merkezlerine ulastirilir. En yaygin ambalaj sekli, 4, 5, 8 veya 10 litrelik bidonlar veya ambalajlar halinde paketlenmis olarak kullanima sunulmasidir. Bidon ambalaj seklinin en önemli avantaji; farkli Asidik solüsyon (2) terkiplerinin hazirlanmasina müsait olmasidir. Bidon ambalajlama seklinin dezavantaji ise çökmedir. Konsantre diyalizat solüsyonu doyma noktasina yakin olan "derisik solüsyondur". Konsantre çözelti sinir duruma yakin ve çökmeye meyillidir. Bidon ambalajlama metodunda, soguma ve beklemeden mütevvellid solüsyonun çökmesinden ve partiküllerin adhezyondan kaynakli mikstür bozulmasinin önüne geçilememektedir. Çökme diyaliz seansi boyunca kullanilan diyalizatin terkibinde degisiklige sebep olmaktadir. Çökme neticesinde hastanin elektrolit balansi menfi etkilenmekte ve diyaliz tedavisinin kalitesini bozmaktadir. Çökme sebebiyle aktüel - kullanilan solüsyonun içerigi hedeflenen solüsyondan farklidir. Diyaliz hastasinin vücut kitlesi, kan hacmi, Diyalizör (8) ebadi ve pompa hizi gibi sebeplerle Hastalarin diyalizat solüsyonu kullanim miktari degisiklik gösterir. Hasta için kullanilan bidon ambalajdaki solüsyonun bir kismi artar ve artan solüsyon atilarak ziyan olur. Bidonlar halinde ambalajlanmis diyalizat tedariginin bir diger sorunlari ise; Bidon ambalaj maliyetinin diyalizat solüsyonlarinin maliyetini arttirmasi, Konsantre solüsyon içindeki su ve bidonlarin tasima maliyetinin nakliye maliyetini arttirmasi, Bidonlarin depolanmasinin isletme maliyetini arttirmasi, Diyalizat bidonlarinin merkez içinde tasinmasinin personelin is yükünü ve maliyetini arttirmasi ve bidon ambalajlar kontaminasyona müsait olmasidir. Diyalizat üretim ve dagitiminin bir diger uygulama sekli diyalizat solüsyonlarinin fabrikada hazirlanip dökme olarak, tanker ile klinige gönderilmesi seklindedir. Temel olarak bidon maliyetinden tasarruf edilebilmesi için kullanilan bir yöntemdir. Dökme diyalizat sistemleri yöntem, hijyen ve personel yükü sebebi ile yayginlasmamistir. Dökme Asidik solüsyon (2) kullaniminin bir diger dezavantaji ise farkli içerikteki Asidik solüsyonlarin (2) kullanimina imkan vermemesidir. Diyalizat solüsyon üretim ve dagitimin bir diger metodu ise kuru toz olarak solüsyonun diyaliz merkezine gönderilmesi ve diyaliz merkezinde Saf su (1) ile karistirilarak solüsyon haline döndürülüp kullanilmasidir. Bazik solüsyon (3) standart olarak sodium bikarbonat içerir. Bazik solüsyonun (3) sabit içerige sahip olmasi sebebi ile kuru toz formunda sodyum bikarbonat içeren kartuslar mevcutta kullanilmaktadir. Sodyum bikarbonat kartuslari her bir diyaliz makinesi için tek kullanimlik ve tek bir hastanin ihtiyacini karsilayacak sekilde imal edilip kulanilirlar. Ancak bu kartuslarin içinde bulunan sodyum bikarbonatin su ile çözülmesi ve bikarbonat içeren Bazik solüsyon (3) olusturmasi sabit bir süreç degildir. Yaklasik 4 saat süren diyaliz seansinin ilk zamanlarinda kartusta çözünen bikarbonat miktari yüksek olup hedeflenen Bazik solüsyon (3) çözeltisinden derisik olur. Diyaliz seansinin ilerleyen saatlerinde ise çözünen bikarbonat miktari azalir ve Bazik solüsyon (3) konsantrasyonu hedeflenen degere nazaran seyreltik olur. Bu sebeple bu tip ambalajlarda hasta için sabit konsantrasyonda Bazik solüsyon (3) hazirlanmasi mümkün degildir. Bazik solüsyon (3) için merkezi solusyon hazirlama tanklari üretilmis ve dünyada kullanilmaktadir. Ancak Asidik solüsyonun (2) terkibi hastaya göre degismektedir. Asidik solüsyonun (2) terkibi özellikle potasyum ve kalsiyum tuzlarinin miktarina bagli degisiklik arzeder. Hekimlerin farkli diyalizat solüsyonlarini kullanmak zorunda olmalari, merkezi diyalizat dagitim sistemlerinin kurulmasinin önündeki temel engeldir. Bu sebeple Asidik solüsyon (2), Bazik solüsyon (3) gibi merkezi olarak hazirlanmaz. Standart çözelti özelliginde olan kuru Asidik solüsyon (2) paketleri ve merkezi solüsyon hazirlama makineleri de piyasada vardir. Ancak bu standart solüsyonlar, farkli hastalar için gereken farkli mikstürdeki solüsyonlari hazirlayamaz tek tip solüsyon üretebilirler. Asidik solüsyonun (2) merkezi olarak üretilmesinin bir diger engeli, içeriginde Asetik asidin bulunmasi geregidir. Asetik asit, solüsyonun ihtiyaci olan pH degerini saglar ve solüsyonu olusturan bilesenlerin karisabilmesi için gereken iyonik ortami hazirlar. Ideal karisim kalitesinin saglanabilmesi için ve karisimin unsurlari olan tuzlarin ve glikozun tam olarak çözünebilmesi için karisimi olusturan her maddenin belli fizik sartlarda ve protokol dahilinde, sira ile karisima gönderilmesi gerekir. Çözelti içindeki partiküllerin erimesi için isi ve basinç altinda filtrelerden geçirilmesi gerekmektedir. Asetik asit yerine kuru - toz formunda kullanilabilecek farkli formüller denenmistir. Ancak bu tip solüsyonlar, bilimsel otoriteler tarafindan önerilmemektedir. Hazirlanacak solüsyonun kimyevi dogrulugunun ispati gerekmektedir. Mevcut laboratuar analiz yöntemleri kullanildiginda pahali laboratuar düzenegi kurulmasi gerekmektedir. Yine bu testlerin yapilmasi için yetismis personele ihtiyaç duyulacaktir. Bulusun amaci; Bulus; diyalizat solüsyonunun merkezde hazirlanmasi için kuru formda; sodyum klorür, potasyum klorür, kalsiyum klorür, magnezyum klorür, glikoz, sodyum bikarbonat ve seyreltik sivi formunda asetik asit kullanarak; solüsyonun merkezde hazirlanmasini saglayan cihaz ve sarf malzemeleri hakkindadir. Hedeflenen diyaliz tedavi maliyetini azaltan ve tibbi kaliteyi artiran ürün gelistirmektir. Bulus ile; ihtiyaca bagli olarak farkli kimyevi mikstüre haiz Asidik solüsyon (2) hazirlanmasi, solüsyonun terkibini ve kalitesini test edecek donanim gelistirilmesi, solüsyon hazirlama, dagitim, yedekleme ve temizleme için donanim gelistirilmesi hedeflenmistir. Bulus ile; ambalaj, nakliye, depolama tasarrufu saglanmasi, solusyonun kapali ortamda tutulmasi yolu ile kontaminasyonun engellenmesi ve solüsyonun taze ve homojen olmasi sayesinde diyaliz kalitesinin artmasi hedeflenmektedir. Bulusun amacina ulasmasi için gelistirilen teknik ekli sekiller ile sekillendirilmis olup, bu sekillerden; Sekil 1 Diyaliz tedavisi akis semasini Sekil 2 Diyalizat dagitim sistemi isletim akis semasini Sekil 3 Ek solüsyon pompasini Sekil 4 Ek solüsyon pompasi isletim akis semasini Sekil 5 Asidik solüsyon hazirlama akis semasini Sekil 6 Bazik solüsyon hazirlama akis semasini Sekil 7 Ek solüsyon sarf malzemesini göstermektedir. Sekillerdeki unsurlar numaralandirilmis olup karsiliklari asagida gösterilmistir. 1) Saf su 2) Asidik solüsyon 3) Bazik solüsyon 4) Diyalizat girisi ) Diyalizat çikisi 6) Kan girisi 7) Kan çikisi 8) Diyalizör 9) Diyaliz makinesi ) Tuz sarf malzemesi 11) Glikoz sarf malzemesi 13) Bikarbonat sarf malzemesi ) Potasyum solüsyon sarf malzemesi 16) Kalsiyum solüsyon sarf malzemesi 17) Magnezyum solüsyon sarf malzemesi ) Ek solüsyon sisesi 31) Hava giris hortumu 32) Klemp 33) Ek solüsyon hortumu 34) Persitaltik pompa baglantisi ) Diyalizat hatti baglanti memesi 50) Ek solüsyon pompasi 51) Yikama tahliye valfi 52) Atik hatti 53) Peristaltik dosaj pompasi valfi 54) Ek solüsyon sarf malzemesi yuvasi 55) Peristaltik pompa tamburu 56) Asidik solüsyon - diyaliz makinesi baglanti hatti 57) Bazik solüsyon - diyaliz makinesi baglanti hatti 58) Ek solüsyon pompasi güç butonu Ek solüsyon pompasi devir ayar dügmesi Asidik solüsyon servis hatti - ek solüsyon pompasi baglantisi Bazik solusyon servis hatti - ek solusyon pompasi baglantisi Asidik solüsyon makinesi Asidik solüsyon saf su giris valfi Asidik solüsyon saf su giris hassas valfi Asidik solüsyon akisölçer Asidik solüsyon karisim tanki Asidik solüsyon iletkenlik sensörü Asidik solüsyon karistiricisi Asidik solüsyon isiticisi Asidik solüsyon pH sensörü Asidik solüsyon sicaklik sensörü Asidik solüsyon hazirlama tanki partikül ölçüm donanimi Asidik solüsyon hazirlama tanki UV sterilizasyon donanimi Asidik solüsyon aksiller çikis vanasi Asidik solüsyon devridaim pompasi valfi Asidik solüsyon devridaim pompasi Asidik solüsyon tank dönüs valfi Tuz tank valfi Tuz tanki Tuz tanki çikis filtresi Tuz tanki çikis valfi Glikoz tank valfi Glikoz tanki Glikoz tanki çikis filtresi Glikoz tanki çikis valfi Asetik asit tank valfi Asetik asit tanki Asetik asit çikis filtresi Asetik asit tanki çikis valfi Asidik solüsyon tank dönüs pompasi Asidik solüsyon servis çikis valfi Asidik solüsyon servis çikis filtresi Asidik solüsyon basinç transmitteri Asidik solüsyon yikama çikis valfi Asidik solüsyon yedek tank valfi Asidik solüsyon servis hatti Asidik solüsyon yikama çikis hatti Asidik solüsyon hazirlama tanki hava tahliye vanasi Asidik solüsyon yedekleme makinesi Asidik solüsyon yedek tanki saf su giris valfi Asidik solüsyon yedek tanki seviye sensörü Asidik solüsyon yedek tanki karistiricisi Asidik solüsyon yedek tanki isiticisi Asidik solüsyon yedek tanki sicaklik sensörü Asidik solüsyon yedek tanki çikis pompasi Asidik solüsyon yedek tanki - asidik solüsyon tanki dönüs valfi Asidik solüsyon yedek tanki yikama çikis valfi Asidik solüsyon yedek tanki hava tahliye vanasi Asidik solüsyon yedek tanki Bazik solüsyon makinesi Bazik solüsyon saf su giris valfi Bazik solüsyon saf su giris hassas valfi Bazik solüsyon akisölçer Bazik solüsyon karisim tanki Bazik solüsyon seviye sensörü Bazik solüsyon iletkenlik sensörü Bazik solüsyon karistiricisi Bazik solüsyon isiticisi Bazik solüsyon pH sensörü Bazik solüsyon sicaklik sensörü Bazik solüsyon hazirlama tanki partikül ölçüm donanimi Bazik solüsyon hazirlama tanki UV sterilizasyon donanimi Bazik solüsyon aksiller çikis vanasi Bazik solüsyon devridaim pompasi valfi Bazik solüsyon devridaim pompasi Bazik solüsyon tank dönüs valfi Bikarbonat tank valfi Bikarbonat tanki Bikarbonat çikis filtresi Bikarbonat tanki çikis valfi Bazik solüsyon tank dönüs pompasi Bazik solüsyon servis çikis valfi Bazik solüsyon servis çikis filtresi 224) Bazik solüsyon basinç transmitteri 225) Bazik solüsyon yikama çikis valfi 226) Bazik solüsyon yedek tank valfi 227) Bazik solüsyon servis hatti 228) Bazik solüsyon yikama çikis hatti 229) Bazik solüsyon hazirlama tanki hava tahliye vanasi 250) Bazik solüsyon yedekleme makinesi 251) Bazik solüsyon yedek tanki saf su giris valfi 252) Bazik solüsyon yedek tanki seviye sensörü 253) Bazik solüsyon yedek tanki karistiricisi 254) Bazik solüsyon yedek tanki isiticisi 255) Bazik solüsyon yedek tanki sicaklik sensörü 256) Bazik solüsyon yedek tanki çikis pompasi 257) Bazik solüsyon yedek tanki - bazik solusyon tankli dönüs valfi 258) Bazik solüsyon yedek tanki yikama çikis valfi 259) Bazik solüsyon yedek tanki hava tahliye vanasi 260) Bazik solüsyon yedek tanki Bulus kapsaminda; kimyevi maddelerin dogru olarak karistirilmasini ve solüsyonun hazirlanmasini saglamak amaci ile özellesmis bir proses sistemi gelistirilmesinin yani sira Tuz sarf malzemesi (10), Glikoz sarf malzemesi (11), Asetik asit sarf malzemesi (12), Bikarbonat sarf malzemesi (13) gelistirilmistir. Bulus kapsaminda, farkli Asidik solüsyon (2) tiplerini üretebilmek için; tek kullanimlik, Saf su (1) içinde çözünmüs halde Potasyum içeren; Potasyum solüsyon sarf malzemesi (15), Kalsiyum içeren; Kalsiyum solüsyon sarf malzemesi (16) ve Magnezyum içeren; Magnezyum solüsyon sarf malzemesi (17) gelistirmistir. Ek solusyon sarf malzemesi için farkli terkip ve konsantrasyonlara haiz olan ilave Ek solusyon sarf malzemesi de kullanilabilir. Ek solusyon sarf malzemelerinin kullanimi için Ek solüsyon pompasi (50) gelistirilmistir. Tuz sarf malzemesi (10), Glikoz sarf malzemesi (11), Asetik asit sarf malzemesi (12), Bikarbonat sarf malzemesi (13) birden fazla ve tercihan 10 seansa yetecek miktarda kimyevi madde ihtiva edecek sekilde hazirlanmistir. Sarf malzemeleri tek veya 20 seansa veya daha çok miktarda seansa yetecek miktarlardaki paketler halinde de hazirlanabilir. Tuz sarf malzemesi (10), Glikoz sarf malzemesi (11) ve Bikarbonat sarf malzemesi (13) Kuru toz - pudra formunda ambalajlanmistir. Asetik asit sarf malzemesi (12) ise %25 lik sulu çözelti formunda veya daha farkli konsantrasyonda ambalajlanir. seansa yetecek miktarda paketlenmis olan Tuz sarf malzemesi (10), Glikoz sarf malzemesi (11) ve Asetik asit sarf malzemesi (12) Asidik solüsyon makinesi (100) ile 50 litre solüsyon olacak sekilde Saf su (1) ile sulandirilarak, Asidik solüsyon (2) hazirlanir. seansa yetecek miktarda paketlenmis olan Bikarbonat sarf malzemesi (13) Bazik solüsyon makinesi (200) ile 50 litre solüsyon olacak sekilde Saf su (1) ile sulandirilarak, Asidik solüsyon (2) ve Bazik solüsyon (3) farkli yogunluklarda hazirlanabilir. Asidik solüsyon karisim tanki (104) ve Bazik solüsyon karisim tanki (204) kapasitesine bagli olarak 1 veya daha fazla Tuz sarf malzemesi (10), Glikoz sarf malzemesi (11) ve Asetik asit sarf malzemesi (12) kullanilarak hazirlanan Asidik solüsyon (2) ve Bikarbonat sarf malzemesi (13) kullanilarak hazirlanan Bazik solüsyon (3); Diyaliz makinesinde (9), 34 kat veya farkli oranlarda Saf su (1) kullanilarak seyreltilir. Diyaliz makinesi (9) tarafindan sulandirilan Diyalizat solüsyonu 138 mmol/litre Sodyuml", 2 mmol/litre Potasyuml", 1,25 mmol/litre Kalsiyum(") 0,75 mmol/litre Magnezyum(**),112 mmol/litre Klor('), 32 mmol/litre Bikarbonat", 3 mmol/litre Asetat" ve 1 gr/litre Glikoz içerir. Diyalizat solüsyonun kimyevi degerleri degisik konsantrasyonlarda hazirlanabilir. Bulusun çözmeyi hedefledigi asli sorun; kuru toz formundaki baslangiç maddelerinden farkli içerikte Asidik solüsyon (2) hazirlanmasini saglamaktir. Bulus kapsaminda gelistirilen Potasyum solüsyon sarf malzemesi (15), Asidik solüsyon (2) ile karistirildiginda, Asidik solüsyon (2) degerine 1 mmol/lt ilave Potasyum ve 1 mmol/lt Klorür ilave edecek sekilde gelistirilmistir. Bulus kapsaminda gelistirilen Kalsiyum solüsyon sarf malzemesi (16), Asidik solüsyon (2) ile karistirildiginda, Asidik solüsyon (2) degerine 0,5 mmol/lt ilave Kalsiyum ve 1 mmol/lt Klorür ilave edecek sekilde gelistirilmistir. Bulus kapsaminda gelistirilen Magnezyum solüsyon sarf malzemesi (17), Asidik solüsyon (2) ile karistirildiginda, Asidik solüsyon (2) degerine 0,25 mmol/lt ilave Magnezyum ve 0,5 mmol/lt Klorür ilave edecek sekilde gelistirilmistir. Potasyum solüsyon sarf malzemesi (15), Kalsiyum solüsyon sarf malzemesi (16), Magnezyum solüsyon sarf malzemesi (17) hazirlanirken farkli madde miktarlari ve farkli kimyevi maddeler kullanilabilir. Bulus kapsaminda gelistirilen Asidik solüsyon makinesi (100) kullanilarak; baslangiç kimyasallari olan Tuz sarf malzemesi (10) Tuz tankinin (118) içine, Glikoz sarf malzemesi içine konulur. Tuz tanki (118), Glikoz tanki (122) ve Asetik asit tanki (126) bir veya birden fazla miktarda sarf malzemesi alacak ebattadir. Hazirlanacak solüsyon miktari ve seyreltme orani isletim sistemi bilgisayarina bagli olarak çalisan ara yüz ile operatör tarafindan seçilir. Sekil 5 de Asidik solüsyon hazirlama akis semasinda gösterildigi üzere Asidik solüsyon makinesini (100) olusturan parçalar, parçalarin islevi ve makinenin çalisma sekli ifade edilmistir. Gelistirilen bulus kapsaminda Asidik solüsyon makinesinin (100) çalisma prosedürü; Hazirlanacak olan solüsyon miktarinin operatör tarafindan seçimine bagli olarak; Saf su (1) Asidik solüsyon saf su giris valfi (101) yolu ile Asidik solüsyon karisim tankina (104) alinir. Su miktari Asidik solüsyon seviye sensörü (105) ve Asidik solüsyon akisölçeri (103) ile izlenir. Gereken su miktarina yaklasildiginda, Asidik solüsyon saf su giris valfi (101) kapatilir ve Asidik solüsyon saf su giris hassas valfi (102) açilir. Su miktari hedeflenen düzeye eristiginde Asidik solüsyon saf su giris hassas valfi (102) kapatilir. Asidik solüsyon karisim tankina (104) alinan Saf su (1) Asidik solüsyon isiticisi (108) ile isitilir. Su sicakligi Asidik solüsyon sicaklik sensörü (110) ile takip edilir. Isitma ile suya karistirilan kimyasallarin çözünmesini kolaylastirir. Asidik solüsyon karisim tanki (104) içinde bulunan, motor tahrikli Asidik solüsyon karistiricisi (107) ile Asidik solüsyon (2) sürekli karistirilir. Asetik asit tanki (126) içinde bulunan Asetik asit sarf malzemesi (12) Asetik asit çikis filtresinden (127) geçirilir. Asetik asit tank valfi (125) açilir ve Asidik solüsyon tank dönüs pompasi (129) ile Asidik solüsyon karisim tankina (104) pompalanir. Asidik solüsyon karisim tankinin (104) içindeki asetik asit miktari Asidik solüsyon pH sensörü (109) ile izlenir. Asetik asit tanki (126) bosaldigi Asidik solüsyon pH sensörü (109) ile tespit edilince, Asetik asit tankinin (126) içindeki kalinti asetik asiti yikamak amaciyla, Asidik solüsyon karisim tankinin (104) çikisinda bulunan Asidik solüsyon devridaim pompasi valfi (114) ve Asetik asit tank valfi (125) açilir, Asidik solüsyon karisim tankinin (104) içinde bulunan su ve asit karisimi Asidik solüsyon devridaim pompasi (115) ile Asetik asit tankinin (126) içine pompalanir. Asetik asit tanki (126) içinde kalan Asetik asit sarf malzemesi (12), Asetik asit çikis filtresinden (127) geçirilerek, Asidik solüsyon tank dönüs pompasi (129) ile Asidik solüsyon karisim tankina (104) pompalanir. Asidik solüsyon karisim tankinin (104) çikisinda bulunan Asidik solüsyon devridaim pompasi valfi (114) ve Tuz tank valfi (117) açilarak Asidik solüsyon karisim tankinin (104) içinde bulunan su ve asit karisimi Asidik solüsyon devridaim pompasi (115) ile Tuz tanki (118) içine pompalanir. Tuz tanki (118) içinde biriken su ve asit karisimi Tuz sarf malzemesini (10) eritir. Eriyik Tuz tanki çikis filtresinden (119) geçer. Tuz tanki çikis valfi (120) açilir ve Tuz tanki (118) içinde bulunan su asit ve tuz karisimi Asidik solüsyon tank dönüs pompasi (129) ile Asidik solüsyon karisim tankina (104) pompalanir. Islem Tuz tanki (118) içinde bulunan tüm Tuz sarf malzemesi (10) eriyene kadar devam eder. Islem Asidik solüsyon iletkenlik sensörü (106) ile izlenir. Asidik solüsyon karisim tankinin (104) çikisinda bulunan Asidik solüsyon devridaim pompasi valfi (114) ve Glikoz tank valfi (121) açilarak Asidik solüsyon karisim tanki (104) içinde bulunan su, tuz ve asit karisimi Asidik solüsyon devridaim pompasi (115) ile Glikoz tanki (122) içine pompalanir. Glikoz tanki (122) içinde biriken su, tuz ve asit karisimi Glikoz sarf malzemesini (11) eritir. Eriyik Glikoz tanki çikis filtresinden (123) geçer. Glikoz tanki (122) içinde bulunan su, asit, tuz ve glikoz karisimi, Glikoz tanki çikis valfi (124) açilarak Asidik solüsyon tank dönüs pompasi (129) ile Asidik solüsyon karisim tankina (104) pompalanir. Islem Glikoz tankinin (122) içinde bulunan tüm Glikoz sarf malzemesi (11) eriyene kadar devam eder. Islem Asidik solüsyon iletkenlik sensörü (106) ile izlenir. Asidik solüsyon karisim tankinin (104) çikisinda bulunan Asidik solüsyon devridaim pompasi valfi (114) ve Asidik solüsyon tank dönüs valfi (116) açilarak, Asidik solüsyon devridaim pompasi (115) ile Asidik solüsyon karisim tankinin (104) içinde bulunan Asidik solüsyon (2) tekrar Asidik solüsyon karisim tankina (104) pompalanarak ilave karistirma etkisi saglanir. Solusyon hazirlama prosedüründeki sira farkli uygulamalara göre degistirilebilir. Asidik solüsyon karisim tankinin (104) içinde hazirlalan Asidik solüsyonun (2) kalitesi Asidik solüsyon iletkenlik sensörü (106) ve Asidik solüsyon hazirlama tanki partikül ölçüm donanimi (111) ile test edilir. Asidik solüsyon servis çikis valfi (130) açilip, hazirlanan Asidik solüsyon (2), Asidik solüsyon servis çikis filtresinden (131) geçirilir ve Asidik solüsyon devridaim pompasi (115) ile Asidik solüsyon servis hatti (135) verilir. Asidik solüsyon (2) basinci, Asidik solüsyon basinç transmitteri (132) ile kontrol edilir. Basinca bagli olarak Asidik solüsyon devridaim pompasinin (115) devri kontrol edilir. Asidik solüsyon servis hattina (135) pompalanan Asidik solüsyon (2), Asidik solüsyon servis hatti - ek solüsyon pompasi baglantisi (60) ile Ek solüsyon pompasina (50) iletilir. Asidik solüsyon servis hattindan (135) dönen, kullanilmayan Asidik solüsyon (2), Asidik solüsyon karisim tanki (104) geri döner. Bulus kapsaminda gelistirilen teknikle; Asidik solüsyon karisim tankinin (104) içine yerlestirilen Asidik solüsyon hazirlama tanki UV sterilizasyon donanimi (112) sayesinde Asidik solüsyon (2) steril edilir. Bulus kapsaminda gelistirilen, Asidik solüsyonun (2) muhtevasini degistirmek üzere tasarlanan ve Sekil 3 te gösterilen Ek solüsyon pompasi (50) üç kanali olan peristaltik pompadir. Ayni anda bir, iki veya üç Ek solüsyon sarf malzemesinin (14) kullanilmasina imkan verir. Sekil 7 de gösterilen ve kullanilacak Asidik solüsyonun (2) içerigini degistirmek için kullanilan Ek solüsyon sarf malzemesinin (14) takilabilecegi yuvalar olan Ek solüsyon sarf malzemesi yuvalarina (54) sahiptir. Klinisyenin tercihine göre bir veya birden fazla Potasyum solüsyon sarf malzemesi (15), Kalsiyum solüsyon sarf malzemesi (16) veya Magnezyum solüsyon sarf malzemesi (17) niteliginde olan veya farkli terkipteki Ek solüsyon sarf malzemeleri (14), Ek solüsyon sarf malzemesi yuvalarina (54) yerlestirilir. Ek solüsyon sisesine (30) bagli Ek solüsyon hortumu (33), üzerine sabitlenmis Persitaltik pompa baglantisi (34) adi verilen plastik parça ile Ek solüsyon pompasina (50) sabitlenir. Ek solüsyon hortumu (33); Peristaltik pompa tamburu (55) üzerinden geçirilerek sabitlenir. Ek solüsyon hortumunun (33) çikis ucunda bulunan Diyalizat hatti baglanti memesi (35) adi verilen plastik parça ile Peristaltik dosaj pompasi valfi (53) baglanir. Ek solüsyon hortumu (33) üzerinde bulunan Klemp (32) açilir ve böylece Ek solüsyon sarf malzemelerinin (14) içinde bulunan katki solüsyonu, Asidik solüsyon (2) ile karisarak Asidik solüsyon - diyaliz makinesi baglanti hatti (56) üzerinden Diyaliz makinesine (9) gönderilir. Ek solüsyon pompasinin (50) isletim semasi Sekil 4 de gösterilmistir. Ek solüsyon pompasinin (50) pompalama hizi klinisyenin tercihine göre degistirilebilir. Ek solüsyon pompasi (50) kullanilacagi zaman devreye alinabilmesi için Ek solüsyon pompasi güç butonu (58) ile aktiflestirilerek devreye alinir. Ek solüsyon pompasi devir ayar dügmesi (59) kullanilarak, Ek solüsyon pompasinin (50) devrini ayarlanabilir. Yeni Asidik solüsyon (2) hazirlanmasi gerektiginde veya Asidik solüsyon makinesinin (100) yikanmasi gerektiginde Asidik solüsyon karisim tankinin (104) içerisinde kalan Asidik solüsyon (2), Asidik solüsyon yedek tankina (160) alinir. Bu islem için Asidik solüsyon karisim tankinin (104) çikisinda bulunan Asidik solüsyon devridaim pompasi valfi (114) ve Asidik solüsyon yedek tank valfi (134) açilir, Asidik solüsyon devridaim pompasi (115) çalistirilarak Asidik solüsyon karisim tankinin (104) içinde bulunan Asidik solüsyon (2), Asidik solüsyon yedek tankina (160) pompalanir. Islem Asidik solüsyon yedek tanki seviye sensörü (152) ile takip edilir. Eger Asidik solüsyon yedek tanki (160) solüsyon seviyesi tasma mesafesine yükselirse, Asidik solüsyon yedek tanki yikama çikis valfi (158) açilir ve fazla solusyon Asidik solüsyon yikama çikis hattina (136) verilerek atilir. Asidik solüsyon yedek tanki (160) içindeki Asidik solüsyon (2), Asidik solüsyon yedek tanki karistiricisi (153) ile karistirilarak çökelti olusmasi engellenir. Asidik solüsyon yedek tanki (160) içindeki Asidik solüsyon (2), Asidik solüsyon yedek tanki isiticisi (154) ile isitilarak sicak tutulur. Islem Asidik solüsyon yedek tanki sicaklik sensörü (155) ile takip edilir. Asidik solüsyon yedek tankinin (160) içindeki Asidik solüsyonu (2) kullanmak üzere Asidik solüsyon karisim tankina (104) aktarmak için; Asidik solüsyon yedek tanki - asidik solüsyon tanki dönüs valfi (157) açilir, Asidik solüsyon yedek tanki çikis pompasi (156) ile Asidik solüsyon yedek tankinin (160) içindeki Asidik solüsyonu (2), Asidik solüsyon karisim tankina (104) pompalanir. Bulus kapsaminda gelistirilen Bazik solüsyon makinesi (200) kullanilarak; baslangiç kimyasallari olan Bikarbonat sarf malzemesi (13) Bikarbonat tankinin (218) içine konulur. Bikarbonat tanki (218) bir veya birden fazla miktarda sarf malzemesi alacak ebattadir. Hazirlanacak solüsyon miktari ve seyreltme orani isletim sistemi bilgisayarina bagli olarak çalisan ara yüz ile operatör tarafindan seçilir. Sekil 6 da Bazik solusyon hazirlama akis semasinda gösterildigi üzere Bazik solüsyon makinesini (200) olusturan parçalar, parçalarin islevi ve makinenin çalisma sekli ifade edilmistir. Gelistirilen bulus kapsaminda Bazik solüsyon makinesinin (200) çalisma prosedürü; Hazirlanacak olan solüsyon miktarinin seçimine bagli olarak; Saf su (1), Bazik solüsyon saf su giris valfi (201) yolu ile Bazik solüsyon karisim tankina (204) alinir. Su miktari Bazik solüsyon seviye sensörü (205) ve Bazik solüsyon akisölçeri (203) üzerinden izlenir. Gereken su miktarina yaklasildiginda, Bazik solüsyon saf su giris valfi (201) kapatilir ve Bazik solüsyon saf su giris hassas valfi (202) açilir. Su miktari hedeflenen düzeye eristiginde Bazik solüsyon saf su giris hassas valfi (202) kapatilir. Bazik solüsyon karisim tanki (204) alinan Saf su (1), Bazik solüsyon isiticisi (208) ile isitilir. Su sicakligi Bazik solüsyon sicaklik sensörü (210) ile takip edilir. Isitma ile suya karistirilan kimyasallarin çözünmesini kolaylastirir. Bazik solüsyon karisim tanki (204) içinde bulunan, motor tahrikli Bazik solüsyon karistiricisi (207) ile Bazik solüsyon (3) karistirilir. Bazik solüsyon karisim tankinin (204) çikisinda bulunan Bazik solüsyon devridaim pompasi valfi (214) ve Bikarbonat tank valfi (217) açilarak Bazik solüsyon karisim tankinin (204) içinde bulunan su Bazik solüsyon devridaim pompasi (215) ile Bikarbonat tanki (218) içine pompalanir. Bikarbonat tanki (218) içine alinan su Bikarbonat sarf malzemesini (13) eritir. Eriyik Bikarbonat çikis filtresinden (219) geçer. Bikarbonat tanki çikis valfi (220) açilarak Bikarbonat tanki (218) içinde bulunan su ve bikarbonat karisimi Bazik solüsyon tank dönüs pompasi (221) ile Bazik solüsyon karisim tankina (204) pompalanir. Islem Bikarbonat tanki (218) içinde bulunan tüm Bikarbonat sarf malzemesi (13) eriyene kadar devam eder. Islem Bazik solüsyon iletkenlik sensörü (206) ve Bazik solüsyon pH sensörü (209) ile izlenir. Bazik solüsyon karisim tankinin (204) çikisinda bulunan Bazik solüsyon devridaim pompasi valfi (214) ve Bazik solüsyon tank dönüs valfi (216) açilarak, Bazik solüsyon devridaim pompasi (215) ile Bazik solüsyon karisim tankinin (204) içinde bulunan Bazik solüsyon (3) tekrar Bazik solüsyon karisim tanki (204) pompalanarak ilave karistirma etkisi saglanir. Bazik solüsyon karisim tankinin (204) içinde hazirlalan Bazik solüsyonun (3) kalitesi Bazik solüsyon iletkenlik sensörü (206) ve Bazik solüsyon hazirlama tanki partikül ölçüm donanimi (211) ile test edilir. Bazik solüsyon servis çikis valfi (222) açilip, hazirlanan Bazik solüsyon (3), Bazik solüsyon servis çikis filtresinden (223) geçirilir ve Bazik solüsyon devridaim pompasi (215) ile, Bazik solüsyon servis hattina (227) verilir. Bazik solüsyon (3) basinci, Bazik solüsyon basinç transmitteri (224) ile kontrol edilir. Basinca bagli olarak Bazik solüsyon devridaim pompasinin (215) devri kontrol edilir. Bazik solüsyon servis hattina (227) pompalanan Bazik solüsyon (3), Bazik solüsyon servis hatti - ek solüsyon pompasi baglantisi (61) ile Ek solüsyon pompasina (50) iletilir. Bazik solüsyon (3), Bazik solüsyon - diyaliz makinesi baglanti hatti (57) üzerinden Diyaliz makinesine (9) gönderilir. Bazik solüsyon servis hattindan (227) dönen, kullanilmayan Bazik solüsyon (3) Bazik solüsyon karisim tankina (204) geri döner. Bulus kapsaminda gelistirilen teknikle Bazik solüsyon karisim tanki (204) içine yerlestirilen Bazik solüsyon hazirlama tanki UV sterilizasyon donanimi (212) sayesinde Bazik solüsyon (3) steril edilir. Yeni Bazik solüsyon (3) hazirlanmasi gerektiginde veya Bazik solüsyon makinesinin (200) yikanmasi gerektiginde Bazik solüsyon karisim tankinin (204) içerisinde kalan Bazik solüsyon (3), Bazik solüsyon yedek tankina (260) alinir. Bu islem için Bazik solüsyon karisim tankinin (204) çikisinda bulunan Bazik solüsyon devridaim pompasi valfi (214) ve Bazik solüsyon yedek tank valfi (226) açilir, Bazik solüsyon devridaim pompasi (215) çalistirilarak Bazik solüsyon karisim tankinin (204) içinde bulunan Bazik solüsyon (3), Bazik solüsyon yedekleme tankina (260) pompalanir. Islem Bazik solüsyon yedek tanki seviye sensörü (252) ile takip edilir. Eger Bazik solüsyon yedek tanki (260) solüsyon seviyesi tasma mesafesine yükselirse, Bazik solüsyon yedek tanki yikama çikis valfi (258) açilir ve fazla solusyon Bazik solüsyon yikama çikis hatti (228) verilerek atilir. Bazik solüsyon yedek tanki (260) içindeki Bazik solüsyon (3); Bazik solüsyon yedek tanki karistiricisi (253) ile karistirilarak çökelti olusmasi engellenir. Bazik solüsyon yedek tanki (260) içindeki Bazik solüsyon (3); Bazik solüsyon yedek tanki isiticisi (254) ile isitilarak sicak tutulur. Islem Bazik solüsyon yedek tanki sicaklik sensörü (255) ile takip edilir. Bazik solüsyon yedek tankinin (260) içindeki Bazik solüsyonu (3) kullanilmak üzere Bazik solüsyon karisim tanki (204) aktarmak için; Bazik solüsyon yedek tanki - bazik solüsyon tankli dönüs valfi (257) açilir, Bazik solüsyon yedek tanki çikis pompasi (256) ile Bazik solüsyon (3), Bazik solüsyon karisim tanki (204) pompalanir. Bulus kapsaminda gelistirilen teknik ile, Asidik solüsyon (2) ve Bazik solüsyonun (3) terkibini analiz etmek ve uygunlugunu denetlemek için Asidik solüsyon iletkenlik sensörü (106), Asidik solüsyon pH sensörü (109), Bazik solüsyon iletkenlik sensörü (206), Bazik solüsyon pH sensörü (209) kullanilmaktadir. Iletkenlik ve pH degerleri hazirlanan algoritma sayesinde solüsyonun terkibinin dogrulugu hakkinda genis çözünürlüklü bilgi edinilmesini saglamaktadir. Hazirlanan solüsyon Asidik solüsyon isiticisi (108) ve Bazik solüsyon isiticisi (208) kullanilarak sicak tutulmaktadir. Ayni sekilde Asidik solüsyon karistiricisi (107) ve Bazik solüsyon karistiricisi (207) kullanilarak karistirilarak homojen tutuldugu için "taze çözelti" olarak ve kapali sistem içinde Sekil 2 de gösterilen Diyalizat dagitim sistemi isletim akis semasina bagli olarak Diyaliz makinelerine (9) gönderilmektedir. Bulus kapsaminda, Asidik solüsyonun (2) ve Bazik solüsyonun (3) diyaliz merkezindeki Diyaliz makinelerine (9) ulastirilmasi için diyalizat dagitim sistemi gelistirilmistir. Asidik solüsyon makinesinin (100), Asidik solüsyon servis çikis valfi (130) açilir ve Asidik solüsyon devridaim pompasi (115) ile Asidik solüsyon (2) diyaliz merkezindeki her Diyaliz makinesi (9) ile birlikte çalisan Ek solüsyon pompasina (50) ulasan boru sisteminden olusan Asidik solüsyon servis hatti (135) pompalanir. Asidik solüsyon servis hatti (135), Asidik solüsyon servis hatti - ek solüsyon pompasi baglantisina (60) baglanir. Ek solüsyon pompasina (50) ulasan Asidik solüsyon (2) içine zerk edilen Ek solüsyon sarf malzemesi (14) ile karistirilarak Asidik solüsyon - diyaliz makinesi baglanti hatti (56) üzerinden Diyaliz makinesinin (9) asidik solüsyon baglanti probuna baglanir ve böylece Diyaliz makinesine (9) ulasmis olur. Bazik solüsyon makinesinin (200), Bazik solüsyon servis çikis valfi (222) açilir ve Bazik solüsyon (3), Bazik solüsyon devridaim pompasi (215) ile diyaliz merkezindeki her Diyaliz makinesi (9) ile birlikte çalisan Ek solüsyon pompasina (50) ulasan boru sisteminden olusan Bazik solüsyon servis hattina (227) pompalanir. Bazik solüsyon servis hatti (227), Bazik solüsyon servis hatti - ek solüsyon pompasi baglantisina (61) baglanir. Ek solüsyon pompasi (50) ulasan Bazik solüsyon (2), Bazik solüsyon - diyaliz makinesi baglanti hatti (57) üzerinden Diyaliz makinesi (9) bazik solusyon baglanti probuna baglanir ve böylece Diyaliz makinesine (9) ulasmis olur. Bulus kapsaminda diyalizat dagitim borularinin yikanabilmesi için tank yikamasi ile birlikte çalisan ilave yikama sistemi gelistirilmistir. Diyalizat yogun bir çözelti oldugu için, makinenin kullanilmadigi süre zarfinda dagitim sistemi borulari içinde çökebilir. Çöken kimyasallar sisteme verilecek diyalizatin içerigini degistirecegi gibi bir süre sonra borularda tikanmaya yol açacaktir. Bu sebeple diyaliz merkezinin kapali oldugu süre zarfinda sistemin yikanmasi ve sistemde bulunan suyun yikama sonrasinda tahliyesi gerekmektedir. Asidik solüsyon makinesinin (100) yikanmasi için Asidik solüsyon saf su giris valfi (101), Asidik solüsyon aksiller çikis vanasi (113), ve Atik hattina (52) baglanan Asidik solüsyon yikama çikis valfi (133) konulmustur. Bazik solüsyon makinesi (200) yikanmasi için Bazik solüsyon saf su giris valfi (201), Bazik solüsyon aksiller çikis vanasi (213) ve Atik hattina (52) baglanan Bazik solüsyon yikama çikis valfi (225) konulmustur. Asidik solüsyon yedek tankinin (160) yikanmasi için Asidik solüsyon yedek tanki saf su giris valfi (151) ve Atik hattina (52) baglanan Asidik solüsyon yedek tanki yikama çikis valfi (158) konulmustur. Bazik solüsyon yedek tankinin (260) yikanmasi için Bazik solüsyon yedek tanki saf su giris valfi (251) ve Atik hattina (52) baglanan Bazik solüsyon yedek tanki yikama çikis valfi (258) konulmustur. Diyalizat solüsyonu diyaliz makinesi içine peristaltik pompa ile negatif basinç altinda çekilir. Peristaltik pompalar kanatli pompalar gibi akiskanin serbest hareket edebildigi pompalar degildir. Bu nedenle diyalizat sistemi yikama islemi yaparken dagitim sistemine pompalayacagi yikama solüsyonu diyaliz makinesinde bulunan persitaltik pompanin kapali olmasi sebebi ile ilerleyemeyecektir. Dagitim sisteminde bulunan diyalizat veya yikama solüsyonunun basinci düsük tutulmak zorundadir. Aksi halde basinçli solüsyon diyaliz makinesinde hasara yol açar. Bu sebeple sadece devridaim pompasi kullanarak yikama solüsyonunun veya diyalizat solüsyonun basinçlandirilmasi mümkün degildir. Dagitim sistemini olusturan boru hattinin yikanmasi isleminin güvenle ve otomatik olarak yapilabilmesi için her Diyaliz makinesinin (9) diyalizat sistemi ile baglanti noktasinda bulunan Ek solüsyon pompasinin (50), Atik hatti (52) açilan, asidik ve bazik Yikama tahliye valfleri (51) konulmustur. Böylece sistem yikama islemine basladiginda solüsyon tanklarindan pompalanan yikama solüsyonu Yikama tahliye valfleri (51) açilarak; solüsyonun diyaliz makinesine gitmesini engelleyip Atik hattina (52) yönlendirirler. Yikama tahliye valfleri (51) sayesinde yikama sonrasinda sistemde kalan solüsyonun tahliyesi yapilir. Bulus kapsaminda gelistirilen teknikle; sistemin yikanmasi gerektiginde Asidik solüsyon makinesinden (100), Asidik solüsyon servis hatti (135) pompalalan yikama solüsyonu, Ek solüsyon pompasi (50) bagli olan Yikama tahliye valfi (51) açilarak Atik hattina (52) gönderilir. Bazik solüsyon makinesinden (200), Bazik solüsyon servis hattina (227) pompalalan yikama solusyonu, Ek solüsyon pompasina (50) bagli olan Yikama tahliye valfi (51) açilarak Atik hattina (52) gönderilir. Gerek görülmesi halinde Tuz tanki (118) veBikarbonat tanki (218) tanki içine deterjan ve benzeri kimyasallar konularak yikama islemi yapilabilir. TR TR DESCRIPTION DRY DIALIZATE PREPARATION, DISTRIBUTION, DOSING SYSTEM AND CONSUMABLES Known state of the technique; Dialysate solution; In the hemodialysis process performed on the basis of filtration, it is used as a balancing solution with the targeted concentration as a result of dialysis in the retantate compartment of the dialyzer membrane. In hemodialysis treatment, the patient's blood is passed through the permeate part of the filter called dialyzer by the dialysis machine. The dialyzer has a semi-permeable membrane. The membrane is in the form of tubes in the form of hollow fiber, and there are a varying number of these tubes in the dialyzer, between 5,000 and 0,000. The total surface area of the dialyzer membrane is between 0.7 and 2.2 square meters. With the Dialysis treatment flow diagram shown in Figure 1; Blood taken from the patient; It enters the blood inlet (6) of the dialyzer (8), passes through the membrane tubes, and exits the blood outlet (7) and is given back to the patient. During the dialysis process, ion exchange occurs between the blood and the dialysate fluid outside the membrane wall. During the dialysis process, metabolic residues accumulated in the blood and water accumulated in the body pass through the dialyzer membrane and are equalized with the amounts of substances in the dialysate solution. Substances found in dialysate solution and blood; Complete excretion of substances such as water, sodium, potassium, calcium and magnesium is prevented and the amount of these substances in the blood is reduced to the normal values that should be present in the blood. During the dialysis process, excess water accumulated in the blood, salts and substances such as urea and creatinine, which are metabolic residues, are excreted through the membrane wall, and shaped elements, proteins and cells remain in the blood because they cannot pass through the membrane wall. Dialysis fluid solutions used in hemodialysis treatment; It is prepared in two different forms as Acidic solution (2) and Basic solution (3) and as a concentrated solution. Both solutions are diluted and mixed with pure water (1) in the Dialysis machine (9). The prepared mixture is pumped from the dialysate inlet (4) of the dialyzer (8) and washes the dialysis membranes from the outside. It then comes out of the Dialysis fluid outlet (5) of the Dialyzer (8) and is thrown away. Acidic solution (2); It is prepared by mixing sodium chloride, potassium chloride, calcium chloride, magnesium chloride, glucose and acetic acid. The content of the acidic solution (2) varies depending on the patient's needs. Potassium in the dialysate fluid is between 1 and 3 mmol/lt, Calcium is between 1 and 2 mmol/lt, Magnesium is between 0.25 and 1 mmol/lt, or it is prepared as a concentrated solution at different values. Basic solution (3) Consists of sodium bicarbonate. It is prepared so that the Bicarbonate value in the dialysate fluid is 32 mmol/lt or as a concentrated solution with different values. It uses dialysate solutions prepared as concentrated solutions by diluting them in 1/35, 1/45 or different ratios in the dialysis machine. The reason for preparing the solution as "Concentrated" is to reduce packaging and transportation costs. Dialysis is performed mostly in dialysis centers all over the world. Dialysis fluid solutions are produced in three different packaging forms and delivered to dialysis centers. The most common form of packaging is to offer it in 4, 5, 8 or 10 liter drums or packages. The most important advantage of the canister packaging method is; It is suitable for the preparation of different acidic solution (2) compositions. The disadvantage of the canister packaging method is collapse. Concentrated dialysate solution is a "concentrated solution" that is close to its saturation point. Concentrated solution is close to the nervous state and tends to precipitate. In the canister packaging method, precipitation of the solution resulting from cooling and waiting and deterioration of the mix due to adhesion of particles cannot be prevented. Precipitation causes changes in the composition of the dialysate used during the dialysis session. As a result of the collapse, the patient's electrolyte balance is negatively affected and the quality of dialysis treatment is impaired. Due to precipitation, the content of the actual solution used is different from the targeted solution. The amount of dialysate solution used by patients varies due to reasons such as the dialysis patient's body mass, blood volume, Dialyzer (8) size and pump speed. Some of the solution in the canister used for the patient is left over and the remaining solution is thrown away and wasted. Another problem with the supply of dialysate packaged in drums is; The cost of canister packaging increases the cost of dialysate solutions, the transportation cost of water and canisters in concentrated solution increases the transportation cost, the storage of canisters increases the operating cost, the transportation of dialysate canisters within the center increases the workload and cost of the staff, and the canister packaging is prone to contamination. Another application of dialysate production and distribution is that dialysate solutions are prepared in the factory and sent to the clinic in bulk by tanker. It is basically a method used to save on drum costs. Bulk dialysate systems have not become widespread due to method, hygiene and personnel burden. Another disadvantage of using bulk acidic solution (2) is that it does not allow the use of acidic solutions (2) with different contents. Another method of dialysate solution production and distribution is to send the solution as dry powder to the dialysis center and mix it with pure water (1) at the dialysis center to turn it into a solution and use it. Basic solution (3) contains sodium bicarbonate as standard. Since the basic solution (3) has a constant content, cartridges containing sodium bicarbonate in dry powder form are currently used. Sodium bicarbonate cartridges are manufactured and used for single use for each dialysis machine and to meet the needs of a single patient. However, dissolving the sodium bicarbonate contained in these cartridges with water and forming a Basic solution (3) containing bicarbonate is not a constant process. In the early days of the dialysis session, which lasts approximately 4 hours, the amount of bicarbonate dissolved in the cartridge is high and the targeted Basic solution (3) is concentrated from the solution. As the dialysis session progresses, the amount of dissolved bicarbonate decreases and the concentration of the Basic solution (3) becomes diluted compared to the targeted value. For this reason, it is not possible to prepare a fixed concentration of Basic solution (3) for the patient in this type of packaging. Central solution preparation tanks for basic solution (3) have been produced and are used around the world. However, the composition of the acidic solution (2) varies depending on the patient. The composition of the acidic solution (2) varies depending on the amount of potassium and calcium salts. The fact that physicians have to use different dialysate solutions is the main obstacle to the establishment of centralized dialysate distribution systems. For this reason, the Acidic solution (2) is not prepared centrally like the Basic solution (3). Dry Acidic solution (2) packages and central solution preparation machines, which have standard solution features, are also available on the market. However, these standard solutions cannot prepare different mixtures of solutions required for different patients; they can only produce a single type of solution. Another obstacle to the central production of acidic solution (2) is that it must contain acetic acid. Acetic acid provides the pH value needed by the solution and prepares the ionic environment required for the components that make up the solution to mix. In order to ensure the ideal mixture quality and to fully dissolve the salts and glucose, which are the elements of the mixture, each substance forming the mixture must be sent to the mixture in order, under certain physical conditions and within the framework of the protocol. In order for the particles in the solution to melt, they must be filtered under heat and pressure. Different formulas that can be used in dry or powder form instead of acetic acid have been tried. However, such solutions are not recommended by scientific authorities. It is necessary to prove the chemical accuracy of the solution to be prepared. When existing laboratory analysis methods are used, expensive laboratory equipment must be established. Again, trained personnel will be needed to perform these tests. The purpose of the invention; Meet; in dry form for the preparation of dialysate solution in the center; using sodium chloride, potassium chloride, calcium chloride, magnesium chloride, glucose, sodium bicarbonate and acetic acid in dilute liquid form; It is about the devices and consumables that enable the solution to be prepared at the center. The aim is to develop products that reduce the cost of dialysis treatment and increase medical quality. With the invention; It is aimed to prepare acidic solution (2) with different chemical mixtures depending on the need, to develop equipment to test the composition and quality of the solution, and to develop equipment for solution preparation, distribution, backup and cleaning. With the invention; It is aimed to increase the quality of dialysis by providing savings in packaging, transportation and storage, preventing contamination by keeping the solution in a closed environment and keeping the solution fresh and homogeneous. The technique developed to achieve the purpose of the invention has been shaped by the attached figures, of which; Figure 1 shows the dialysis treatment flow diagram. Figure 2 shows the dialysate distribution system operating flow diagram. Figure 3 shows the additional solution pump. Figure 4 shows the additional solution pump operating flow diagram. Figure 5 shows the acidic solution preparation flow diagram. Figure 6 shows the basic solution preparation flow diagram. Figure 7 shows the additional solution consumables. The elements in the figures are numbered and their equivalents are shown below. 1) Pure water 2) Acidic solution 3) Basic solution 4) Dialysate inlet ) Dialysate outlet 6) Blood inlet 7) Blood outlet 8) Dialyzer 9) Dialysis machine ) Salt consumable 11) Glucose consumable 13) Bicarbonate consumable ) Potassium solution consumable 16) Calcium solution consumable 17) Magnesium solution consumable ) Additional solution bottle 31) Air inlet hose 32) Clamp 33) Additional solution hose 34) Peristaltic pump connection ) Dialysis fluid line connection nozzle 50) Additional solution pump 51) Washing discharge valve 52) Waste line 53) Peristaltic dosing pump valve 54) Additional solution consumable holder 55) Peristaltic pump drum 56) Acidic solution - dialysis machine connection line 57) Basic solution - dialysis machine connection line 58) Additional solution pump power button Additional solution pump speed adjustment knob Acidic solution service line - additional solution pump connection Basic solution service line - additional solution pump connection Acidic solution machine Acidic solution pure water inlet valve Acidic solution pure water inlet sensitive valve Acidic solution flowmeter Acidic solution mixing tank Acidic solution conductivity sensor Acidic solution mixer Acidic solution heater Acidic solution pH sensor Acidic solution temperature sensor Acidic solution preparation tank particle measuring equipment Acidic solution preparation tank UV sterilization equipment Acidic solution axillary outlet valve Acidic solution circulation pump valve Acidic solution circulation pump Acidic solution tank return valve Salt tank valve Salt tank Salt tank outlet filter Salt tank outlet valve Glucose tank valve Glucose tank Glucose tank outlet filter Glucose tank outlet valve Acetic acid tank valve Acetic acid tank Acetic acid outlet filter Acetic acid tank outlet valve Acidic solution tank return pump Acidic solution service outlet valve Acidic solution service outlet filter Acidic solution pressure transmitter Acidic solution washing outlet valve Acidic solution backup tank valve Acidic solution service line Acidic solution washing outlet line Acidic solution preparation tank air release valve Acidic solution backup machine Acidic solution backup tank pure water inlet valve Acidic solution backup tank level sensor Acidic solution reserve tank agitator Acidic solution reserve tank heater Acidic solution reserve tank temperature sensor Acidic solution reserve tank outlet pump Acidic solution reserve tank - acidic solution tank return valve Acidic solution reserve tank flush outlet valve Acidic solution reserve tank air release valve Acidic solution spare tank Basic solution machine Basic solution pure water inlet valve Basic solution pure water inlet sensitive valve Basic solution flowmeter Basic solution mixing tank Basic solution level sensor Basic solution conductivity sensor Basic solution mixer Basic solution heater Basic solution pH sensor Basic solution temperature sensor Basic solution preparation tank particle measurement equipment Basic solution preparation tank UV sterilization equipment Basic solution axillary outlet valve Basic solution circulation pump valve Basic solution circulation pump Basic solution tank return valve Bicarbonate tank valve Bicarbonate tank Bicarbonate outlet filter Bicarbonate tank outlet valve Basic solution tank return pump Basic solution service outlet valve Basic solution service outlet filter 224) Basic solution pressure transmitter 225) Basic solution washing outlet valve 226) Basic solution reserve tank valve 227) Basic solution service line 228) Basic solution washing outlet line 229) Basic solution preparation tank air release valve 250 ) Basic solution backup machine 251) Basic solution backup tank pure water inlet valve 252) Basic solution backup tank level sensor 253) Basic solution backup tank agitator 254) Basic solution backup tank heater 255) Basic solution backup tank temperature sensor 256) Basic solution backup tank outlet pump 257) Basic solution spare tank - basic solution tank return valve 258) Basic solution spare tank washing outlet valve 259) Basic solution spare tank air release valve 260) Basic solution spare tank Within the scope of the invention; In addition to developing a specialized process system to ensure the correct mixing of chemical substances and preparation of the solution, Salt consumables (10), Glucose consumables (11), Acetic acid consumables (12), Bicarbonate consumables (13) have been developed. Within the scope of the invention, in order to produce different types of acidic solutions (2); single use, Containing Potassium dissolved in pure water (1); Potassium solution consumable (15), containing calcium; Containing calcium solution consumables (16) and Magnesium; Magnesium solution consumable material (17) has been developed. Additional additional solution consumables with different compositions and concentrations can also be used for additional solution consumables. Additional solution pump (50) has been developed for the use of additional solution consumables. Salt consumable (10), Glucose consumable (11), Acetic acid consumable (12), Bicarbonate consumable (13) are prepared to contain enough chemicals for more than one session and preferably for 10 sessions. Consumables can be prepared individually or in packages sufficient for 20 or more sessions. Salt consumable (10), Glucose consumable (11) and Bicarbonate consumable (13) are packaged in dry powder form. Acetic acid consumable (12) is packaged in the form of 25% aqueous solution or in a different concentration. Salt consumables (10), Glucose consumables (11) and Acetic acid consumables (12), packaged in sufficient quantities for the session, are diluted with Pure water (1) with the Acidic solution machine (100) to make 50 liters of solution, and the Acidic solution (2 ) is prepared. Acidic solution (2) and Basic solution (3) can be prepared in different densities by diluting the Bicarbonate consumable (13), packaged in sufficient quantity for the session, with Pure water (1) to make 50 liters of solution with the Basic solution machine (200). Acidic solution (2) prepared by using 1 or more Salt consumables (10), Glucose consumables (11) and Acetic acid consumables (12), depending on the capacity of the Acidic solution mixing tank (104) and Basic solution mixing tank (204). and Basic solution (3) prepared using Bicarbonate consumable (13); It is diluted 34 times or in different proportions using Pure water (1) in the dialysis machine (9). Dialysate solution diluted by the dialysis machine (9) 138 mmol/liter Sodium, 2 mmol/liter Potassium, 1.25 mmol/liter Calcium("), 0.75 mmol/liter Magnesium(**), 112 mmol/liter Chlorine ('), 32 mmol/liter Bicarbonate", 3 mmol/liter Acetate" and 1 g/liter Glucose. The chemical values of the dialysate solution can be prepared in different concentrations. The main problem that the invention aims to solve is the acidic solution (2) with different content than the starting materials in dry powder form. ) The Potassium solution consumable (15) developed within the scope of the invention has been developed in such a way that when mixed with the Acidic solution (2), it will add 1 mmol/lt additional Potassium and 1 mmol/lt Chloride to the acidic solution (2). The Magnesium solution consumable (17) developed within the scope of the invention has been developed to add 0.5 mmol/lt additional Calcium and 1 mmol/lt Chloride to the acidic solution (2) when mixed with the acidic solution (2). It has been developed to add 0.25 mmol/lt additional Magnesium and 0.5 mmol/lt Chloride to the acidic solution (2) when mixed with acidic solution (2). Different amounts of substances and different chemicals can be used when preparing the Potassium solution consumable (15), Calcium solution consumable (16), Magnesium solution consumable (17). By using the acidic solution machine (100) developed within the scope of the invention; Salt consumable (10), which is the starting chemicals, is placed in the Salt tank (118), and Glucose consumable is placed in it. Salt tank (118), Glucose tank (122) and Acetic acid tank (126) are large enough to hold one or more consumables. The amount of solution to be prepared and the dilution rate are selected by the operator through the interface connected to the operating system computer. As shown in the Acidic solution preparation flow chart in Figure 5, the parts that make up the Acidic solution machine (100), the functions of the parts and the way the machine works are expressed. The operating procedure of the acidic solution machine (100) within the scope of the developed invention; Depending on the operator's choice of the amount of solution to be prepared; Pure water (1) Acidic solution is taken into the acidic solution mixing tank (104) via the pure water inlet valve (101). The amount of water is monitored by the Acidic solution level sensor (105) and the Acidic solution flowmeter (103). When the required amount of water is approached, the Acidic solution pure water inlet valve (101) is closed and the Acidic solution pure water inlet sensitive valve (102) is opened. When the amount of water reaches the target level, the acidic solution pure water inlet sensitive valve (102) is closed. Pure water (1) taken into the acidic solution mixing tank (104) is heated by the acidic solution heater (108). Water temperature is monitored by the acidic solution temperature sensor (110). It facilitates the dissolution of chemicals mixed into water by heating. The acidic solution (2) is constantly mixed with the motor-driven acidic solution mixer (107) located in the acidic solution mixing tank (104). Acetic acid consumable material (12) in the acetic acid tank (126) is passed through the acetic acid outlet filter (127). The acetic acid tank valve (125) is opened and the acidic solution is pumped to the acidic solution mixing tank (104) with the tank return pump (129). The amount of acetic acid in the acidic solution mixing tank (104) is monitored by the acidic solution pH sensor (109). When it is detected by the acidic solution pH sensor (109) that the acetic acid tank (126) is empty, the acidic solution circulation pump valve (114) and the acetic solution circulation pump valve (114) located at the outlet of the acidic solution mixing tank (104) are used to wash the residual acetic acid in the acetic acid tank (126). The acid tank valve (125) is opened, the water and acid mixture in the acidic solution mixing tank (104) is pumped into the acetic acid tank (126) by the acidic solution circulation pump (115). The Acetic acid consumable material (12) remaining in the Acetic acid tank (126) is passed through the Acetic acid outlet filter (127) and pumped to the Acidic solution mixing tank (104) by the Acidic solution tank return pump (129). By opening the acidic solution circulation pump valve (114) and salt tank valve (117) at the outlet of the acidic solution mixing tank (104), the water and acid mixture in the acidic solution mixing tank (104) is transferred to the salt tank (118) with the acidic solution circulation pump (115). ) is pumped into it. The mixture of water and acid accumulated in the salt tank (118) melts the salt consumable (10). It passes through the Molten Salt tank outlet filter (119). The salt tank outlet valve (120) is opened and the water, acid and salt mixture in the salt tank (118) is pumped to the acidic solution mixture tank (104) with the acidic solution tank return pump (129). The process continues until all the Salt consumables (10) in the Salt tank (118) are melted. The process is monitored by the acidic solution conductivity sensor (106). The acidic solution circulation pump valve (114) and Glucose tank valve (121) at the outlet of the acidic solution mixing tank (104) are opened, and the water, salt and acid mixture in the acidic solution mixing tank (104) is transferred to the Glucose tank with the acidic solution circulation pump (115). It is pumped into (122). The mixture of water, salt and acid accumulated in the glucose tank (122) melts the glucose consumable (11). The melt passes through the Glucose tank outlet filter (123). The mixture of water, acid, salt and glucose in the glucose tank (122) is pumped to the acidic solution mixture tank (104) by the acidic solution tank return pump (129) by opening the glucose tank outlet valve (124). The process continues until all the Glucose consumable material (11) in the Glucose tank (122) is melted. The process is monitored by the acidic solution conductivity sensor (106). By opening the acidic solution circulation pump valve (114) and the acidic solution tank return valve (116) at the outlet of the acidic solution mixing tank (104), the acidic solution circulation pump (115) and the acidic solution (2) in the acidic solution mixing tank (104) are opened. The acidic solution is pumped back into the mixing tank (104) to provide an additional mixing effect. The order in the solution preparation procedure can be varied according to different applications. The quality of the acidic solution (2) prepared in the acidic solution mixing tank (104) is tested with the acidic solution conductivity sensor (106) and the acidic solution preparation tank particle measurement equipment (111). The Acidic solution service outlet valve (130) is opened, the prepared Acidic solution (2) is passed through the Acidic solution service outlet filter (131) and is given to the Acidic solution service line (135) with the Acidic solution circulation pump (115). The acidic solution (2) pressure is controlled by the acidic solution pressure transmitter (132). Depending on the pressure, the speed of the acidic solution circulation pump (115) is controlled. The acidic solution (2) pumped to the acidic solution service line (135) is transmitted to the additional solution pump (50) via the Acidic solution service line - additional solution pump connection (60). The unused acidic solution (2), returning from the acidic solution service line (135), returns to the acidic solution mixing tank (104). With the technique developed within the scope of the invention; Acidic solution (2) is sterilized thanks to the UV sterilization equipment (112) of the acidic solution preparation tank placed inside the acidic solution mixing tank (104). The Additional solution pump (50), developed within the scope of the invention, designed to change the content of the acidic solution (2) and shown in Figure 3, is a peristaltic pump with three channels. Allows one, two or three Additional solution consumables (14) to be used at the same time. It has additional solution consumable slots (54), which are shown in Figure 7 and are slots into which the Additional solution consumable material (14) used to change the content of the acidic solution (2) to be used can be installed. Depending on the clinician's preference, one or more Additional solution consumables (14), which are of the nature of Potassium solution consumables (15), Calcium solution consumables (16) or Magnesium solution consumables (17), or of different composition, are placed in the Additional solution consumable slots (54). ) is placed. The Additional solution hose (33) connected to the Additional solution bottle (30) is fixed to the Additional solution pump (50) with the plastic part called Percitaltic pump connection (34) fixed on it. Additional solution hose (33); It is fixed by passing it over the peristaltic pump drum (55). Peristaltic dosing pump valve (53) is connected to the plastic part called Dialysis fluid line connection nozzle (35), located at the outlet end of the additional solution hose (33). The Clamp (32) on the additional solution hose (33) is opened and thus the additive solution contained in the additional solution consumables (14) mixes with the Acidic solution (2) and is transferred to the Dialysis machine (9) via the Acidic solution - dialysis machine connection line (56). is sent. The operating diagram of the additional solution pump (50) is shown in Figure 4. The pumping speed of the additional solution pump (50) can be changed according to the clinician's preference. When the additional solution pump (50) is to be used, it is activated by activating the additional solution pump with the power button (58). The speed of the additional solution pump (50) can be adjusted by using the additional solution pump speed adjustment knob (59). When a new Acidic solution (2) needs to be prepared or the Acidic solution machine (100) needs to be washed, the Acidic solution (2) remaining in the Acidic solution mixing tank (104) is taken to the Acidic solution reserve tank (160). For this process, the Acidic solution circulation pump valve (114) and the Acidic solution reserve tank valve (134) at the outlet of the Acidic solution mixing tank (104) are opened, the Acidic solution circulation pump (115) is operated and the Acidic solution in the Acidic solution mixing tank (104) is opened. (2), Acidic solution is pumped to the reserve tank (160). The process is monitored by the acidic solution reserve tank level sensor (152). If the solution level of the Acidic solution reserve tank (160) rises to the overflow distance, the Acidic solution reserve tank washing outlet valve (158) is opened and the excess solution is discharged to the Acidic solution washing outlet line (136). The acidic solution (2) in the acidic solution reserve tank (160) is mixed with the acidic solution reserve tank mixer (153) to prevent precipitate formation. The acidic solution (2) in the acidic solution reserve tank (160) is kept warm by being heated by the acidic solution reserve tank heater (154). The process is monitored by the acidic solution reserve tank temperature sensor (155). To transfer the acidic solution (2) in the acidic solution reserve tank (160) to the acidic solution mixing tank (104) for use; Acidic solution reserve tank - acidic solution tank return valve (157) is opened, the acidic solution (2) in the acidic solution reserve tank (160) is pumped to the acidic solution mixing tank (104) with the acidic solution reserve tank outlet pump (156). By using the Basic solution machine (200) developed within the scope of the invention; Bicarbonate consumable material (13), which is the starting chemicals, is placed into the Bicarbonate tank (218). The bicarbonate tank (218) is large enough to hold one or more consumables. The amount of solution to be prepared and the dilution rate are selected by the operator through the interface connected to the operating system computer. As shown in the Basic solution preparation flow chart in Figure 6, the parts that make up the Basic solution machine (200), the functions of the parts and the way the machine works are expressed. The operating procedure of the Basic solution machine (200) within the scope of the developed invention; Depending on the selection of the amount of solution to be prepared; Pure water (1) and Basic solution are taken into the Basic solution mixing tank (204) via the pure water inlet valve (201). The amount of water is monitored via the Basic solution level sensor (205) and the Basic solution flowmeter (203). When the required amount of water is approached, the Basic solution pure water inlet valve (201) is closed and the Basic solution pure water inlet sensitive valve (202) is opened. When the amount of water reaches the target level, the Basic solution pure water inlet sensitive valve (202) is closed. Pure water (1) taken from the basic solution mixing tank (204) is heated with the Basic solution heater (208). Water temperature is monitored with the Basic solution temperature sensor (210). It facilitates the dissolution of chemicals mixed into water by heating. Basic solution (3) is mixed with the motor-driven Basic solution mixer (207) located in the Basic solution mixing tank (204). By opening the Basic solution circulation pump valve (214) and Bicarbonate tank valve (217) at the outlet of the Basic solution mixing tank (204), the water in the Basic solution mixing tank (204) is pumped into the Bicarbonate tank (218) by the Basic solution circulation pump (215). . The water taken into the Bicarbonate tank (218) melts the Bicarbonate consumable (13). Melted Bicarbonate passes through the outlet filter (219). By opening the Bicarbonate tank outlet valve (220), the water and bicarbonate mixture in the Bicarbonate tank (218) is pumped to the Basic solution mixture tank (204) by the Basic solution tank return pump (221). The process continues until all the Bicarbonate consumables (13) in the Bicarbonate tank (218) are melted. The process is monitored by the Basic solution conductivity sensor (206) and the Basic solution pH sensor (209). By opening the Basic solution circulation pump valve (214) and the Basic solution tank return valve (216) at the outlet of the Basic solution mixing tank (204), the Basic solution circulation pump (215) and the Basic solution (3) inside the Basic solution mixing tank (204) are opened. Additional mixing effect is provided by pumping the basic solution mixing tank (204) again. The quality of the Basic solution (3) prepared in the Basic solution mixing tank (204) is tested with the Basic solution conductivity sensor (206) and the Basic solution preparation tank particle measurement equipment (211). The Basic solution service outlet valve (222) is opened, the prepared Basic solution (3) is passed through the Basic solution service outlet filter (223) and is given to the Basic solution service line (227) with the Basic solution circulation pump (215). Basic solution (3) pressure is controlled by Basic solution pressure transmitter (224). Depending on the pressure, the speed of the Basic solution circulation pump (215) is controlled. Basic solution (3), pumped to the basic solution service line (227), is transmitted to the additional solution pump (50) via the Basic solution service line - additional solution pump connection (61). Basic solution (3) is sent to the Dialysis machine (9) via the Basic solution - dialysis machine connection line (57). The unused Basic solution (3) returning from the Basic solution service line (227) returns to the Basic solution mixing tank (204). With the technique developed within the scope of the invention, the Basic solution (3) is sterilized by the UV sterilization equipment (212) of the Basic solution preparation tank placed in the Basic solution mixing tank (204). When a new Basic solution (3) needs to be prepared or the Basic solution machine (200) needs to be washed, the Basic solution (3) remaining in the Basic solution mixing tank (204) is taken to the Basic solution reserve tank (260). For this process, the Basic solution circulation pump valve (214) and the Basic solution reserve tank valve (226) at the outlet of the Basic solution mixing tank (204) are opened, the Basic solution circulation pump (215) is operated and the Basic solution in the Basic solution mixing tank (204) is opened. (3), The basic solution is pumped into the backup tank (260). The process is monitored by the Basic solution reserve tank level sensor (252). If the solution level of the Basic solution reserve tank (260) rises to the overflow distance, the Basic solution reserve tank washing outlet valve (258) is opened and the excess solution is discharged through the Basic solution washing outlet line (228). Basic solution (3) in the basic solution reserve tank (260); The basic solution is mixed with the reserve tank mixer (253) to prevent precipitate formation. Basic solution (3) in the basic solution reserve tank (260); The basic solution is kept warm by being heated by the reserve tank heater (254). The process is monitored by the basic solution reserve tank temperature sensor (255). To transfer the Basic solution (3) in the Basic solution reserve tank (260) to the Basic solution mixing tank (204) for use; Basic solution reserve tank - basic solution tank return valve (257) is opened, Basic solution (3) and Basic solution mixing tank (204) are pumped with the Basic solution reserve tank outlet pump (256). With the technique developed within the scope of the invention, Acidic solution conductivity sensor (106), Acidic solution pH sensor (109), Basic solution conductivity sensor (206), Basic solution to analyze the composition of Acidic solution (2) and Basic solution (3) and check their suitability. pH sensor (209) is used. Conductivity and pH values provide wide-resolution information about the accuracy of the composition of the solution, thanks to the prepared algorithm. The prepared solution is kept warm using the Acidic solution heater (108) and Basic solution heater (208). Likewise, since it is kept homogeneous by mixing using the Acidic solution mixer (107) and the Basic solution mixer (207), it is sent to the Dialysis machines (9) as "fresh solution" and in a closed system, depending on the Dialysis fluid distribution system operating flow diagram shown in Figure 2. Within the scope of the invention, a dialysate distribution system has been developed to deliver the Acidic solution (2) and Basic solution (3) to the Dialysis machines (9) in the dialysis center. The Acidic solution service outlet valve (130) of the Acidic solution machine (100) is opened and the Acidic solution circulation pump (115) and the Acidic solution (2) pass through the pipe system reaching the Additional solution pump (50) that works with each Dialysis machine (9) in the dialysis center. The resulting acidic solution is pumped through the service line (135). Acidic solution service line (135) is connected to the Acidic solution service line - additional solution pump connection (60). The additional solution injected into the acidic solution (2) reaching the additional solution pump (50) is mixed with the consumable material (14) and connected to the acidic solution connection probe of the Dialysis machine (9) via the Acidic solution - dialysis machine connection line (56) and thus to the Dialysis machine ( 9) will be reached. The Basic solution service outlet valve (222) of the Basic solution machine (200) is opened and the Pipe reaching the Basic solution (3), the Basic solution circulation pump (215) and the Additional solution pump (50) working with each Dialysis machine (9) in the dialysis center. The basic solution consisting of the system is pumped to the service line (227). The basic solution service line (227) is connected to the Basic solution service line - additional solution pump connection (61). The basic solution (2) reaching the additional solution pump (50) is connected to the basic solution connection probe of the Dialysis machine (9) via the Basic solution - dialysis machine connection line (57) and thus reaches the Dialysis machine (9). Within the scope of the invention, an additional washing system that works together with tank washing has been developed to wash the dialysate distribution pipes. Since dialysate is a dense solution, it may precipitate in the delivery system pipes when the machine is not in use. Precipitated chemicals will change the content of the dialysate to be given to the system and will cause blockage in the pipes after a while. For this reason, the system must be flushed during the time when the dialysis center is closed and the water in the system must be drained after flushing. Acidic solution pure water inlet valve (101), Acidic solution axillary outlet valve (113), and Acidic solution washing outlet valve (133) connected to the waste line (52) are installed to wash the acidic solution machine (100). For washing the basic solution machine (200), a Basic solution pure water inlet valve (201), a Basic solution axillary outlet valve (213) and a Basic solution washing outlet valve (225) connected to the waste line (52) are installed. In order to wash the acidic solution reserve tank (160), the acidic solution reserve tank pure water inlet valve (151) and the acidic solution reserve tank washing outlet valve (158) connected to the waste line (52) are installed. For washing the basic solution reserve tank (260), the Basic solution reserve tank pure water inlet valve (251) and the Basic solution reserve tank washing outlet valve (258) connected to the waste line (52) are installed. The dialysate solution is drawn into the dialysis machine under negative pressure with a peristaltic pump. Peristaltic pumps are not pumps in which the fluid can move freely, like vane pumps. For this reason, while the dialysate system is washing, the washing solution to be pumped into the distribution system will not be able to progress due to the peristaltic pump in the dialysis machine being turned off. The pressure of the dialysate or washing solution in the distribution system must be kept low. Otherwise, the pressurized solution will cause damage to the dialysis machine. For this reason, it is not possible to pressurize the washing solution or dialysate solution using only a circulation pump. In order to wash the pipeline that forms the distribution system safely and automatically, acidic and basic washing discharge valves (51) have been placed on the additional solution pump (50), which is located at the connection point of each Dialysis machine (9) with the dialysate system, and the waste line (52). Thus, when the system starts the washing process, the washing solution pumped from the solution tanks is opened by the washing discharge valves (51); They prevent the solution from going to the dialysis machine and direct it to the Waste line (52). Thanks to the washing discharge valves (51), the solution remaining in the system after washing is discharged. With the technique developed within the scope of the invention; When the system needs to be washed, the washing solution pumped from the Acidic solution machine (100) to the Acidic solution service line (135) is sent to the Waste line (52) by opening the Washing discharge valve (51) connected to the Additional solution pump (50). The washing solution pumped from the basic solution machine (200) to the basic solution service line (227) is sent to the waste line (52) by opening the washing discharge valve (51) connected to the additional solution pump (50). If necessary, washing can be done by adding detergent and similar chemicals into the Salt tank (118) and Bicarbonate tank (218).TR TR
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR2024001758A2 true TR2024001758A2 (en) | 2024-03-21 |
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