TR201904207T4 - Olgun dendritik hücrelerin hazırlanması için bileşimler. - Google Patents
Olgun dendritik hücrelerin hazırlanması için bileşimler. Download PDFInfo
- Publication number
- TR201904207T4 TR201904207T4 TR2019/04207T TR201904207T TR201904207T4 TR 201904207 T4 TR201904207 T4 TR 201904207T4 TR 2019/04207 T TR2019/04207 T TR 2019/04207T TR 201904207 T TR201904207 T TR 201904207T TR 201904207 T4 TR201904207 T4 TR 201904207T4
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- Prior art keywords
- dendritic cells
- compositions
- preparation
- mature dendritic
- relates
- Prior art date
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- 210000004443 dendritic cell Anatomy 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 2
- 229960002986 dinoprostone Drugs 0.000 abstract 2
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 2
- FBFJOZZTIXSPPR-UHFFFAOYSA-N 1-(4-aminobutyl)-2-(ethoxymethyl)imidazo[4,5-c]quinolin-4-amine Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CCCCN)C3=C(N)N=C21 FBFJOZZTIXSPPR-UHFFFAOYSA-N 0.000 abstract 1
- 108010002352 Interleukin-1 Proteins 0.000 abstract 1
- 229940124613 TLR 7/8 agonist Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
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- C12N2501/20—Cytokines; Chemokines
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- C12N2501/2301—Interleukin-1 (IL-1)
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- C12N2501/999—Small molecules not provided for elsewhere
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- Immunology (AREA)
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- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Animal Behavior & Ethology (AREA)
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Abstract
Buluş en az bir olgun olmayan dendritik hücrenin in vitro mastürasyonu için bir yöntem ile ilişkilidir, b yöntem söz konusu olgun olmayan dendritik hücrenin TNF?, IL-1ß, IFNß, a TLR7/8 agonist ve prostaglandin E2 (PG) ile stimüle edilmesini içermektedir. Buna ilaveten, buluş söz konusu faktörleri içeren bir bileşim ile aynı zamanda da buluşun yöntemi ile üretilen olgun dendritik hücreler ile ilişkilidir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06006373A EP1840206A1 (en) | 2006-03-28 | 2006-03-28 | Compositions for the preparation of mature dendritic cells |
US82582206P | 2006-09-15 | 2006-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201904207T4 true TR201904207T4 (tr) | 2019-05-21 |
Family
ID=36441990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/04207T TR201904207T4 (tr) | 2006-03-28 | 2007-03-28 | Olgun dendritik hücrelerin hazırlanması için bileşimler. |
Country Status (13)
Country | Link |
---|---|
US (3) | US8679840B2 (tr) |
EP (4) | EP1840206A1 (tr) |
AU (1) | AU2007229640B2 (tr) |
CA (1) | CA2647622C (tr) |
CY (1) | CY1121448T1 (tr) |
DK (2) | DK2918673T3 (tr) |
ES (2) | ES2718525T3 (tr) |
HU (1) | HUE042138T2 (tr) |
PL (2) | PL2004807T3 (tr) |
PT (2) | PT2004807E (tr) |
SI (1) | SI2918673T1 (tr) |
TR (1) | TR201904207T4 (tr) |
WO (1) | WO2007110240A1 (tr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1780220A1 (en) * | 2005-11-01 | 2007-05-02 | Charité - Universitätsmedizin Berlin | Use of CEACAM8-specific substances for treating autoimmune diseases and a method for screening substances which induce apoptosis |
WO2010049152A1 (en) * | 2008-10-29 | 2010-05-06 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Novel composition for the preparation of mature dendritic cells |
RU2565542C2 (ru) | 2010-02-10 | 2015-10-20 | Иммуникум Аб | Улучшенная композиция для ингибирования пролиферации опухолевых клеток |
AU2011227447B2 (en) * | 2010-03-15 | 2016-04-14 | The Trustees Of The University Of Pennsylvania | System and method of preparing and storing activated mature dendritic cells |
EP2617434A1 (en) * | 2012-01-20 | 2013-07-24 | Laboratorios Del. Dr. Esteve, S.A. | HIV-1 integrase deficient immunogens and methods for loading dendritic cells with said immunogens |
MX2014010482A (es) * | 2012-03-02 | 2015-04-08 | Esteve Labor Dr | Metodo para la preparacion de vacunas de celulas dendriticas. |
SI2788474T1 (sl) * | 2012-12-18 | 2016-01-29 | Immunicum Ab | Ko-diferenciacija monocitov iz alogenskih darovalcev |
US20150335679A1 (en) * | 2014-05-20 | 2015-11-26 | Kiromic, Llc | Methods and Compositions for Treating Malignancies with Dendritic Cells |
WO2017002045A1 (en) | 2015-06-30 | 2017-01-05 | Stemlab, Sa | A viable cell population, method for production and uses thereof |
DK3394247T3 (da) * | 2015-12-23 | 2021-04-12 | Medigene Immunotherapies Gmbh | Ny generering af antigen-specifikke tcr'er |
KR101946572B1 (ko) * | 2017-01-31 | 2019-02-11 | 주식회사 큐라티스 | 면역 관용성 플라즈마사이토이드 수지상 세포 및 그 제조방법 |
GB201711379D0 (en) * | 2017-07-14 | 2017-08-30 | Univ Cape Town | Maturation of dendritic cells |
AU2017431122B2 (en) * | 2017-09-05 | 2021-09-02 | Medigene Immunotherapies Gmbh | Dendritic cell potency assay |
HUE047540T2 (hu) * | 2017-09-20 | 2020-04-28 | Immunicum Ab | Javított allogén dendritikus sejtek rák kezelésében történõ alkalmazásra |
CN109182384A (zh) * | 2018-09-30 | 2019-01-11 | 北京鼎成肽源生物技术有限公司 | 一种rff1细胞的构建方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6558951B1 (en) | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
KR20050027163A (ko) * | 2001-09-06 | 2005-03-17 | 노쓰웨스트 바이오써라퓨틱스, 인크. | Th-1 반응을 위한 단구성 수지상 세포 및 T 세포를프라이밍하기 위한 조성물 및 방법 |
US20050003533A1 (en) * | 2003-05-08 | 2005-01-06 | Pawel Kalinski | Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use |
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2006
- 2006-03-28 EP EP06006373A patent/EP1840206A1/en not_active Withdrawn
-
2007
- 2007-03-28 EP EP15157220.3A patent/EP2918673B1/en active Active
- 2007-03-28 DK DK15157220.3T patent/DK2918673T3/en active
- 2007-03-28 AU AU2007229640A patent/AU2007229640B2/en not_active Ceased
- 2007-03-28 SI SI200732101T patent/SI2918673T1/sl unknown
- 2007-03-28 PL PL07723717T patent/PL2004807T3/pl unknown
- 2007-03-28 US US12/294,453 patent/US8679840B2/en active Active
- 2007-03-28 TR TR2019/04207T patent/TR201904207T4/tr unknown
- 2007-03-28 PT PT77237170T patent/PT2004807E/pt unknown
- 2007-03-28 PT PT15157220T patent/PT2918673T/pt unknown
- 2007-03-28 ES ES15157220T patent/ES2718525T3/es active Active
- 2007-03-28 CA CA2647622A patent/CA2647622C/en active Active
- 2007-03-28 HU HUE15157220A patent/HUE042138T2/hu unknown
- 2007-03-28 EP EP18248089.7A patent/EP3517603A1/en not_active Withdrawn
- 2007-03-28 PL PL15157220T patent/PL2918673T3/pl unknown
- 2007-03-28 WO PCT/EP2007/002773 patent/WO2007110240A1/en active Application Filing
- 2007-03-28 ES ES07723717.0T patent/ES2535835T3/es active Active
- 2007-03-28 EP EP07723717.0A patent/EP2004807B1/en active Active
- 2007-03-28 DK DK07723717.0T patent/DK2004807T3/en active
-
2014
- 2014-02-06 US US14/174,064 patent/US9512402B2/en active Active
-
2016
- 2016-10-25 US US15/333,476 patent/US20170037372A1/en not_active Abandoned
-
2019
- 2019-03-20 CY CY20191100332T patent/CY1121448T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1121448T1 (el) | 2020-05-29 |
EP2004807A1 (en) | 2008-12-24 |
PT2918673T (pt) | 2019-04-23 |
EP2004807B1 (en) | 2015-03-04 |
CA2647622C (en) | 2017-04-18 |
PL2918673T3 (pl) | 2019-08-30 |
PL2004807T3 (pl) | 2015-07-31 |
SI2918673T1 (sl) | 2019-05-31 |
EP2918673B1 (en) | 2019-01-16 |
WO2007110240A1 (en) | 2007-10-04 |
AU2007229640A1 (en) | 2007-10-04 |
ES2718525T3 (es) | 2019-07-02 |
PT2004807E (pt) | 2015-05-20 |
CA2647622A1 (en) | 2007-10-04 |
AU2007229640B2 (en) | 2013-05-02 |
US9512402B2 (en) | 2016-12-06 |
US8679840B2 (en) | 2014-03-25 |
DK2004807T3 (en) | 2015-05-11 |
US20100284976A1 (en) | 2010-11-11 |
US20170037372A1 (en) | 2017-02-09 |
EP3517603A1 (en) | 2019-07-31 |
US20140302096A1 (en) | 2014-10-09 |
HUE042138T2 (hu) | 2019-06-28 |
DK2918673T3 (en) | 2019-04-01 |
EP2918673A1 (en) | 2015-09-16 |
EP1840206A1 (en) | 2007-10-03 |
ES2535835T3 (es) | 2015-05-18 |
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