TR201900844T4 - Tgf-r sinyal inhibitörleri olarak antisens oligonükleotidler. - Google Patents
Tgf-r sinyal inhibitörleri olarak antisens oligonükleotidler. Download PDFInfo
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- TR201900844T4 TR201900844T4 TR2019/00844T TR201900844T TR201900844T4 TR 201900844 T4 TR201900844 T4 TR 201900844T4 TR 2019/00844 T TR2019/00844 T TR 2019/00844T TR 201900844 T TR201900844 T TR 201900844T TR 201900844 T4 TR201900844 T4 TR 201900844T4
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- Prior art keywords
- antisense oligonucleotides
- tgf
- signal inhibitors
- inhibitors
- signal
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- 108020000948 Antisense Oligonucleotides Proteins 0.000 title abstract 3
- 239000000074 antisense oligonucleotide Substances 0.000 title abstract 3
- 238000012230 antisense oligonucleotides Methods 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
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Abstract
Buluş antisens oligonükleotidler, bunların TGF-R sinyal inhibitörleri olarak kullanımı, bu antisens oligonükleotidleri içeren farmasötik kompozisyonlar ve onkolojik hastalıklar dahil nörolojik, nörodejeneratif ve hiperproliferatiflerin profilaksisi ve tedavisi için kullanım ile ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14193368.9A EP3020813A1 (en) | 2014-11-16 | 2014-11-16 | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201900844T4 true TR201900844T4 (tr) | 2019-02-21 |
Family
ID=51900289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/00844T TR201900844T4 (tr) | 2014-11-16 | 2015-11-16 | Tgf-r sinyal inhibitörleri olarak antisens oligonükleotidler. |
Country Status (22)
Country | Link |
---|---|
US (4) | US11213541B2 (tr) |
EP (3) | EP3020813A1 (tr) |
JP (2) | JP6832285B2 (tr) |
KR (2) | KR102310899B1 (tr) |
CN (2) | CN107002082B (tr) |
AU (3) | AU2015345006B2 (tr) |
BR (1) | BR112017006201B1 (tr) |
CA (2) | CA2964834C (tr) |
CL (2) | CL2017001233A1 (tr) |
CY (1) | CY1121110T1 (tr) |
DK (1) | DK3218488T3 (tr) |
ES (1) | ES2705066T3 (tr) |
HU (1) | HUE041793T2 (tr) |
IL (2) | IL251565B (tr) |
MX (2) | MX2017006369A (tr) |
MY (1) | MY181404A (tr) |
PL (1) | PL3218488T3 (tr) |
PT (1) | PT3218488T (tr) |
RU (1) | RU2717454C2 (tr) |
SG (1) | SG11201703127SA (tr) |
TR (1) | TR201900844T4 (tr) |
WO (1) | WO2016075339A1 (tr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3020813A1 (en) * | 2014-11-16 | 2016-05-18 | Neurovision Pharma GmbH | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
WO2019010226A1 (en) * | 2017-07-03 | 2019-01-10 | The Regents Of The University Of California | CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE |
EP3728592A1 (en) * | 2017-12-22 | 2020-10-28 | Roche Innovation Center Copenhagen A/S | Oligonucleotides comprising a phosphorodithioate internucleoside linkage |
EP3728591A1 (en) * | 2017-12-22 | 2020-10-28 | Roche Innovation Center Copenhagen A/S | Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage |
CN111448316A (zh) * | 2017-12-22 | 2020-07-24 | 罗氏创新中心哥本哈根有限公司 | 新的硫代亚磷酰胺 |
WO2022094320A2 (en) * | 2020-10-29 | 2022-05-05 | Garcia Blanco Mariano A | Soluble interleukin-7 receptor (sil7r) modulating therapy to treat cancer |
CN114588160A (zh) * | 2020-12-07 | 2022-06-07 | 四川大学华西医院 | 具有抗肺纤维化作用的次黄碱衍生物 |
CN113992687B (zh) * | 2021-12-28 | 2022-04-08 | 浙江宇视科技有限公司 | 智能业务集群调度方法、装置、电子设备及存储介质 |
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NZ331372A (en) | 1996-02-19 | 2000-01-28 | Nycomed Imaging As | freeze-dried vesicle containing a thermally stabilized ultrasound contrast agent |
US20030064944A1 (en) | 2001-06-21 | 2003-04-03 | Isis Pharmaceuticals Inc. | Antisense modulation of transforming growth factor beta receptor II expression |
DK2752488T3 (da) | 2002-11-18 | 2020-04-20 | Roche Innovation Ct Copenhagen As | Antisense-design |
JP2007502284A (ja) * | 2003-08-13 | 2007-02-08 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | siRNAによるTGFベータII型受容体発現のサイレンシング |
EP1716235B1 (en) * | 2004-02-09 | 2012-06-06 | Ulrich Bogdahn | Inhibitors of tgf-r signaling for treatment of cns disorders |
WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
CN102766630B (zh) | 2006-01-27 | 2014-05-07 | Isis制药公司 | 6-修饰的双环核酸类似物 |
CA2649045C (en) | 2006-04-03 | 2019-06-11 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
ES2389737T3 (es) | 2006-05-11 | 2012-10-31 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos modificados en 5' |
EP2090127A2 (en) | 2006-10-30 | 2009-08-19 | Nokia Corporation | Method, apparatus and system providing operator controlled mobility for user equipment |
WO2008109546A2 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting tgfbr gene expression and uses thereof |
AU2008260277C1 (en) | 2007-05-30 | 2014-04-17 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
ES2376507T5 (es) | 2007-07-05 | 2015-08-31 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos 6-disustituidos |
WO2009067647A1 (en) | 2007-11-21 | 2009-05-28 | Isis Pharmaceuticals, Inc. | Carbocyclic alpha-l-bicyclic nucleic acid analogs |
AU2009272841A1 (en) * | 2008-07-15 | 2010-01-21 | F. Hoffmann-La Roche Ag | Compositions and methods for inhibiting expression of TGF-beta receptor genes |
EA201290152A1 (ru) * | 2009-10-16 | 2012-12-28 | Глаксо Груп Лимитед | Антисмысловые ингибиторы вируса гепатита в (hbv) |
CA2802089A1 (en) * | 2010-06-11 | 2011-12-15 | Antisense Pharma Gmbh | Method for selective oligonucleotide modification |
US9115371B2 (en) * | 2011-08-18 | 2015-08-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Reduction of TGF beta signaling in myeloid cells in the treatment of cancer |
CN104004762B (zh) * | 2014-05-20 | 2016-03-30 | 南京医科大学附属南京儿童医院 | Tgf-r反义序列及其在制备抗气道炎症反应药物中的应用 |
EP3020813A1 (en) * | 2014-11-16 | 2016-05-18 | Neurovision Pharma GmbH | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
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