TR201618140A2 - Barrier Tipped Embolizing Agent Delivery System - Google Patents
Barrier Tipped Embolizing Agent Delivery System Download PDFInfo
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- TR201618140A2 TR201618140A2 TR2016/18140A TR201618140A TR201618140A2 TR 201618140 A2 TR201618140 A2 TR 201618140A2 TR 2016/18140 A TR2016/18140 A TR 2016/18140A TR 201618140 A TR201618140 A TR 201618140A TR 201618140 A2 TR201618140 A2 TR 201618140A2
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- 230000004888 barrier function Effects 0.000 title claims abstract description 28
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 41
- 238000002604 ultrasonography Methods 0.000 claims abstract description 6
- 208000019553 vascular disease Diseases 0.000 claims abstract description 4
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 239000010936 titanium Substances 0.000 claims description 3
- 229910052719 titanium Inorganic materials 0.000 claims description 3
- 229910000684 Cobalt-chrome Inorganic materials 0.000 claims description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
- 238000002583 angiography Methods 0.000 claims description 2
- 239000010952 cobalt-chrome Substances 0.000 claims description 2
- 239000010935 stainless steel Substances 0.000 claims description 2
- 229910001220 stainless steel Inorganic materials 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims 5
- 230000001070 adhesive effect Effects 0.000 claims 5
- 206010053648 Vascular occlusion Diseases 0.000 claims 1
- 208000021331 vascular occlusion disease Diseases 0.000 claims 1
- 210000003462 vein Anatomy 0.000 abstract description 22
- 238000011282 treatment Methods 0.000 abstract description 8
- 230000005540 biological transmission Effects 0.000 abstract description 6
- 238000002347 injection Methods 0.000 abstract description 6
- 239000007924 injection Substances 0.000 abstract description 6
- 230000002792 vascular Effects 0.000 abstract description 3
- 206010046996 Varicose vein Diseases 0.000 abstract description 2
- 230000010102 embolization Effects 0.000 abstract description 2
- 208000027185 varicose disease Diseases 0.000 abstract description 2
- 229910000831 Steel Inorganic materials 0.000 abstract 1
- 210000003484 anatomy Anatomy 0.000 abstract 1
- 239000010959 steel Substances 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000001736 capillary Anatomy 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical compound [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003073 embolic effect Effects 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Buluş, canlılarda aşırı damarsal dilatasyonla oluşan ya da damarın mevcut anatomik yapısının bozulmasından kaynaklı meydana gelen, varis, perforan ven ve kollateral damar hastalıklarında embolizasyon (embolizan ajanla tıkama işlemi) yaparak tedavi sağlamak amaçlı geliştirilmiş, ultrasonografik ve anjiografik marker işlevi gören çelik bariyerli uç, devamlı ve dairesel iletim sağlayan mikroporlar içeren radial ajan teslim sistemi ile ilgilidir. Bu buluş özellikle sistem elemanlarından ultrasonografik ve anjiografik marker işleri gören çelik bariyerli uç ve devamlı dairesel iletim sağlayan mikroporlar vasıtasıyla, daha önceki sistemlerde uygulanan ileri yönde iletim yapmayı engelleyerek, ileri atımlarda meydana gelebilecek komplikasyonları engelleyip, 360° dairesel embolizasyon yapması ve aynı zamanda ultrason ve anjiografik sistemler altında ekojenitesi fazla olması vasıtasıyla daha rahat yer tanzimi yaparak yanlış bölge enjeksiyonunu önlemek ve sistemin daha verimli çalışması ve veriminin arttırılmasının sağlanmasıyla ilgilidir.The invention has been developed for the treatment of varicose veins, perforating vein and collateral vascular diseases caused by excessive vascular dilatation in living organisms or due to disruption of the existing anatomical structure of the vessel. and radial agent delivery system comprising micropores providing circular conduction. In particular, the present invention provides 360 ° circular embolization and also ultrasound and angiographic interventions, preventing complications in forward pulses by preventing the forward transmission applied in previous systems, particularly by means of a steel barrier tip and continuous circular transmission, which serve as ultrasound and angiographic markers from system elements. It is related to avoiding wrong zone injection by providing more convenient ground arrangement by means of having high echogenicity under the systems and providing more efficient operation of the system and increasing the efficiency.
Description
TARIFNAME Bariyer Uçlu Embolizan Ajan Teslim Sistemi Bulus, damarsal genislemenin ve deformasyonun neden oldugu her türlü girisimsel ve cerrahi damarsal hastalik ve klinik tezahürlerinin tedavisi ve önlenmesinde etkin embolizan ajanin damar duvarina tam nüfusunu saglayacak bir iletim sistemidir. DESCRIPTION Barrier Ended Embolizing Agent Delivery System The invention covers all kinds of invasive and effective in the treatment and prevention of surgical vascular disease and its clinical manifestations. It is a delivery system that will provide the full population of the embolizing agent to the vessel wall.
Teknigin Bilinen Durumu Vücudumuzda atar damar, toplardamar ve kilcal damarlar olmak üzere 3 temel kan iletim sistemi bulunmaktadir. Kalpten kanin vücuda dagitilmasi ve dokulara iletilen kanin geri toplanarak kalbe iletilmesi bu sistem sayesinde olmaktadir. Bu sistem gerek atar damar gerek toplardamar gerekse de kilcal damar sevisinde sekteye ugrarsa klinik bulgular vermekte ve çesitli hastaliklara neden olmaktadir. State of the Art In our body, there are 3 basic blood transmission systems: arteries, veins and capillaries. system exists. The distribution of blood from the heart to the body and the return of the blood delivered to the tissues It is thanks to this system that it is collected and transmitted to the heart. This system requires arterial clinical findings if it is interrupted in both vein and capillary vessels and cause various diseases.
Damar hastaliklarinda yillar içerisinde lazer, radyofrekans ve embolizan ajan uygulanmasi gibi cerrahi riski azaltacak sistemler gelistirilmistir. Bu sistemlerin gelistirilmesindeki amaç insanlarin yasla birlikte damarlarinda olusan deformasyonlarin giderek artmasi ve yürümede zorluk, iyilesmeyen yaralar ve günlük hayat kalitesini bozan bir takim sorunlara neden olmasidir. Varis ve hemoroid bu tip hastaliklarin en sik karsilasilan örneklerindendir. Application of laser, radiofrequency and embolizing agent in vascular diseases over the years Systems have been developed to reduce the surgical risk, such as The purpose of developing these systems the gradual increase in the deformations that occur in the veins of people with age and difficulty in walking, non-healing wounds and some problems that impair the quality of daily life. is why. Varicose veins and hemorrhoids are the most common examples of this type of disease.
Toplumda genetik yatkinlik disinda yaslanmanin en sik neden oldugu bu hadiseler hem kozmetik hem de islevsel sorunlar nedeni ile her geçen gün artan sekilde hastaneye basvuru sebebi olmaktadir. These events, which are the most common causes of aging, except for genetic predisposition, are both Applications to the hospital are increasing day by day due to both cosmetic and functional problems. is the reason.
Damarlardaki bu deformasyon tedavi edilmedigi takdirde kisir bir döngüye girer ve saglam damarlara dogru ilerler. Bu nedenle aradaki hasarli kismin onarilmasi ya da sistem disinda birakilmasi tedavi için gereklidir. If this deformation in the veins is not treated, it enters a vicious cycle and remains intact. progresses towards the veins. For this reason, it is necessary to repair the damaged part in between or outside the system. is necessary for treatment.
Bu tekniklerden daha eski olanlar cerrahi düzeltme, lazer ve radyofrekans tedavileridir. The older of these techniques are surgical correction, laser and radiofrequency treatments.
Cerrahi girisim kozmetik nedenler ve de cerrahinin risk olusturdugu komplikasyonlardan kaçinma için yerini girisimsel tekniklere birakmistir. Girisimsel teknik olarak bilinen lazer ve radyofrekansin damara komsu dokularda olusturdugu diger sorunlar ve islemin ek tümesan anestezik uygulama nedeniyle daha fazla anestezik ajan maruziyeti gerektirmesi nedeniyle son dönemde giderek popülerlik kazanan yapistirma teknolojileri gündeme gelmistir. Bu yapistirma teknolojileri üzerine yapilan klinik çalismalarda özellikle tek doz lokal anestezik ajan uygulanmasi ve çevre dokunun korunmasi nedeniyle iyi sonuçlar bildirilmektedir. Surgical intervention is one of the cosmetic reasons and complications that surgery poses a risk. has left its place to interventional techniques for avoidance. The laser known as the interventional technique and other problems caused by radiofrequency in the tissues adjacent to the vessel and additional requiring more anesthetic agent exposure due to tumescent anesthetic administration Adhesion technologies, which have become increasingly popular in recent years, are on the agenda. has arrived. In clinical studies on these bonding technologies, especially single-dose good results due to application of local anesthetic agent and protection of surrounding tissue is reported.
Ilk nesil girisimsel tekniklerin basinda gelen lazer uygulamalari ilk baslangiçta çiplak uçlu direk karsiya ileten lazer sistemleri olarak tasarlanmisti. Ancak bu sistemlerde lazer isinlarinin dogrudan damar ilerisine uygulanmasinin saglam damar yapisini da hasarlandigi ve ek sorunlara yol açtigi görülmüstür. Bu riskleri en aza indirgemek için direk iletim yerine damari kapatmayi hedefleyen lazer isinini damar duvarina yansal olarak ileten sistemler gelistirilmistir. Bu sonuçlar radyofrekans için de ayni olmus ve güncel tedavilerde direkt damara çiplak uçlu uygulanan sistemler terk edilmistir. Henüz gelisimine devam eden embolizan ajan uygulama tekniklerinde bulus konusu sistem ile benzer olabilecek bir uygulama yoktur. Laser applications, which are at the beginning of the first generation interventional techniques, were initially bare-tipped. It was designed as directly transmitting laser systems. However, in these systems the laser The direct application of the rays to the anterior vein also improves the solid vascular structure. It has been seen that it is damaged and causes additional problems. To minimize these risks, direct transmitting the laser beam, which aims to close the vessel instead of conduction, to the vessel wall laterally. systems have been developed. These results were the same for radiofrequency and current treatments. bare-tipped systems applied directly to the vein have been abandoned. Still developing A system that can be similar to the inventive system in embolizing agent application techniques There is no application.
Bulusun Amacl Teknigin mevcut konumundan yola çikilarak bulusun gayesi; direk damar bosluguna iletilen embolizan ajanin proksimale ilerlemesi yerine direk ve sadece tedavi edilmesi arzulanan damar duvarina ulasmasi,, istenmeyen sekilde saglam damara veya ana damara ilerlemesinin önlenmesi ve damar açilan yan dallarin agizlarinin da kapatilmasinda daha etkin çözüm saglanmasidir. Teknigin bilinen durumuna ait sistemlerde embolizan ajan teslim kateterinin ucundaki açik bölümden gönderildiginden tedavi edilecek damarin uç kismina yani ana arterle birlestigi noktaya istenildigi oranda yakinlasma olmamakta bu da operasyonun basari oranini azaltabilmektedir. Bulus konusu teslim sistemi sayesinde kateterin ucundan degil, kateterin damara temas eden radyal yüzeylerinde olusturulan delik/delikler ve/veya küçük mikropor/mikroporlardan embolizan ajani gönderildiginden ve teslim kateterinin uç kisminda bariyer uç kullanildigindan ana damara mümkün oldugunca yakin bir mesafeden embolizan ajani uygulanarak tedavinin basari orani artirilmaktadir. Invention Purpose Based on the current position of the technique, the aim of the invention is; directly to the vascular space Direct and only treatment of the delivered embolizing agent rather than its progression to the proximal reaching the desired vessel wall, inadvertently into an intact vessel or main vessel It is more effective in preventing its progression and closing the mouths of the side branches that open the veins. effective solution is provided. Embolizing agent in systems of the state of the art the end of the vessel to be treated, as it is sent through the open section at the tip of the delivery catheter. It does not get as close as desired to the part of the main artery, that is, to the point where it joins the main artery. can reduce the success rate of the operation. Thanks to the inventive delivery system formed on the radial surfaces of the catheter that contact the vessel, not the tip of the catheter. Since embolizing agent is delivered through hole/holes and/or small micropore/micropores and, since a barrier tip is used at the tip of the delivery catheter, possible access to the main vein The success rate of the treatment by applying the embolizing agent from as close a distance as possible. is being increased.
Bulusun bir baska amaci gelismekte olan embolizan ajan uygulama sistemlerinin daha etkin kullanilmasini saglayarak güvenlik düzeyinin arttirilmasidir. Another aim of the invention is to make developing embolizing agent delivery systems more efficient. It is to increase the level of security by enabling its use.
Buna ek olarak bu iletim sisteminin kullanilmasi ileri teknolojilere de ufuk açacak ve klinisyenleri bu teknolojiler üzerine çalismaya cesaretlendirecektir. In addition, the use of this transmission system will open the horizon to advanced technologies and will encourage clinicians to work on these technologies.
Sekillerin Kßa Anlatlînlve Referans Numaralarl Bulusun daha iyi açiklanabilmesi amaciyla ekte asagida detaylari açiklanan resimler verilmistir: Sekil-l- Bariyer uçlu Embolizan Ajan teslim sisteminin yandan görüntüsü Sekil-Z- Bariyer uçlu Embolizan Ajan teslim sisteminin kesit görüntüsü Sekil-3- Bariyer uçlu Embolizan Ajan teslim sisteminde kullanilan tabancanin kesit görüntüsü Sekil-4- Bariyer uçlu Embolizan Ajan teslim sisteminin asamalarini gösterir resimler Sekil-S- Bariyer uçlu Embolizan Ajan teslim sistemin insan Vücudu üzerindeki uygulama gösterimi Sekillerdeki parçalarin numaralari: Teslim kateteri Bariyer uç Mikropor/delik Girisim kateteri Enjeksiyon baglanti konnektörü Ara kelebek aparati Embolizan enjeksiyon haznesi . Hazne itici sabitleyicisi . Tabanca emniyet kilidinden . Embolizan ajan Bulusun DetaylIAnIlatEm Bulusun da dahil oldugu embolizan ajan teslim sistemleri temel olarak damar içerisine gönderilen girisim kateteri ve bu girisim kateteri içerisinden geçen teslim kateterinden mütesekkildir. Girisim kateteri tedavi edilecek damar içerisinde kilavuz görevi görürken, teslim kateteri tedavi edilecek damara embolizan ajani ulastirir. Embolizan ajan(13] bir tabanca[12) ile damar içerisine gönderilmekte olup, bahsedilen tabanca[12) teslim kateteri[1) ile entegre embolizan enjeksiyon haznesi[7), tetik[8], itici[9), hazne itici sabitleyicisi(10], enjeksiyon tabanca emniyet kilidinden(11) olusmaktadir. Ayrica kateter pozisyonlamayi saglayan ara kelebek aparati[6) ve kilitli enjeksiyon baglanti konnektörü[5] de tabanca ile teslim(1] ve girisim kateterini(4) birbirine baglamaktadir. Brief Description of Figures and Reference Numbers In order to better explain the invention, the attached pictures are described in detail below. given: Figure-l- Side view of the barrier tipped Embolizing Agent delivery system Figure-Z- Cross-section view of the barrier tipped Embolizing Agent delivery system Figure-3- Cross-section of the gun used in the barrier tipped Embolizing Agent delivery system image Figure-4- Pictures showing the stages of the barrier end Embolizing Agent delivery system Figure-S- Barrier-end Embolizing Agent delivery system on human body application display Numbers of parts in the figures: delivery catheter barrier tip micropore/hole intervention catheter Injection port connector Intermediate butterfly apparatus Embolizing injection chamber . Hopper pusher stabilizer . From gun safety lock . embolic agent DETAILED DESCRIPTION OF THE INVENTION Embolizing agent delivery systems, including the invention, are primarily intravenous. from the delivered intervention catheter and the delivery catheter passing through this intervention catheter. is composed of While the intervention catheter acts as a guide in the vessel to be treated, The delivery catheter delivers the embolizing agent to the vessel to be treated. Embolizing agent(13] a It is sent into the vein with the gun[12] and the said gun[12] is delivered. embolizing injection chamber[7) integrated with catheter[1), trigger[8], pusher[9), chamber pusher stabilizer (10) and injection gun safety lock (11). Intermediate butterfly apparatus[6) providing positioning and locked injection connection connector[5] connects the gun with the delivery (1) and the intervention catheter (4).
Mevcut bulusun temel olarak yogunlastigi nokta ise teslim kateterininü) yapisal özellikleri ve teslim kateteri[1] üzerinde yapilan gelistirmelerle ilgilidir. Teslim kateteri[1] üzerinde yapilan yenilik ve gelistirmeler sayesinde yatay düzlemde, teslim kateterinin(1) ucu kapatilmis, delik ve/veya çapi mikron düzeyinde olan mikroporlar(3) sayesinde ileri dogrusal/yatay/düz degil, damar yüzeyine dikey açi ile yayilim yapan ve tercihen 360 derece radyal bir embolizasyon ajan[13) teslim sistemi gelistirilmistir. Teslim kateterinin[1] ucunu kapatmak üzere kateterin(1) uç kisminda bariyer ucu(2) yer almaktadir. Ultrasonografik ve anjiografik marker islevi gören bariyer uç[2] teslim kateterinin [1] uç kismini kapatacak özellikte olup embolizan ajaninin(13] ileri dogru iletim yapmasini engeller ve utrasonografi/anjiografi altinda teslim kateterinin[1) bulundugu konumun net olarak görünmesini saglar. Teslim kateterinin(1) bariyerli ucu[2), tedaviye uygun metal, paslanmaz çelik, kobalt-kromiyum, nitinol[nike1-titanyum] veya titanyum bazli olarak üretilebilir. Diger uygun metaller de bu bulusun kapsami içerisindedir. Ayrica bariyer ucun[2) ön kismi; damar içerisinde kolay yönlenmeyi saglamak ve teslim kateterinin[1] uç kisminin damar içerisindeki olasi istenmeyen zedelenmeleri ve yirtilmalari engellemek, damar yolunda teslim kateterinin(1) daha etkin bir sekilde ilerlemesini saglamak adina yuvarlatilmis eliptik, yumusak bir uca sahiptir. Bariyer ucun[2) uzunlugunun gerekli etkinligi saglamasi adina tercihen 4 cm'den küçük olmasi önerilmektedir. The main focus of the present invention is the structural properties of the delivery catheter. and improvements to the delivery catheter[1]. On delivery catheter[1] Thanks to the innovations and improvements made, the tip of the delivery catheter(1) in the horizontal plane advanced thanks to micropores(3) that are closed, with holes and/or microns in diameter. not linear/horizontal/flat, spreading vertically to the vessel surface and preferably 360 A highly radial embolization agent[13] delivery system has been developed. Delivery A barrier tip(2) is placed on the tip of the catheter(1) to cover the tip of the catheter[1]. takes. Barrier tip that functions as an ultrasonographic and angiographic marker[2] It has the feature to close the tip of the catheter [1] and allows forward conduction of the embolizing agent (13). It prevents the patient from doing it and has a delivery catheter[1) under ultrasonography/angiography. It provides a clear view of the location. The barrier end of the delivery catheter(1)[2] suitable metal, stainless steel, cobalt-chromium, nitinol[nike1-titanium] or titanium can be produced based on Other suitable metals are also within the scope of this invention. Moreover the front of the barrier tip [2]; To provide easy orientation in the vein and to deliver possible unwanted injuries of the tip of the catheter[1] in the vessel and to prevent ruptures, to ensure that the delivery catheter (1) more effectively It has an elliptical, soft tip that is rounded to allow it to advance. Barrier tip[2) The length should preferably be less than 4 cm in order to provide the necessary efficiency. recommended.
Teslim kateterininü) en uç kisminda yer alan bariyer ucun(2] arkasinda istenilen bir bölümde teslim kateteri[1) üzerine devamli ve tercihen dairesel iletim saglayan delikler ve/veya çapi mikron düzeyinde olan mikroporlar(3] bulunmaktadir. Delik ve/veya mikroporlarin[3] bulundugu bu bölüm tercihen bariyer ucun[2) teslim kateterine[1] baglandigi yerden baslayip 2 cm boyunca devam eder. Ancak buradaki uzunluk tedaviye göre arttirip azaltilabilir. Bu delik ve/veya mikroporlarßj tercihen teslim kateterinin tüm dairesel yüzeyinde 3600 [derece] saracak sekilde konumlandirilmistir. Ancak sadece teslim kateterininü) üst kisminda, yaninda veya altinda uygun bir yerde konumlandirilmalari da bu bulusun kapsami içerisindedir. Delikler veya tercihen çapi 100u-400p. boyutlarda olan bu mikroporlar[3]ileri dogru embolizan ajanin iletimini ortadan kaldirip, teslim kateterinden[1] terleme yoluyla damar içerisine 360 derece radyal iletimi saglar. Tercihen mikroporlarin[3] çapinin 300 u olmasi önerilmekle birlikte mikropor[3] tedavi edilecek damarin boyutlarina ve embolizan ajanin akiskanligina göre degisiklik gösterebilir. Yine mikroporlarin[3] veya deliklerin geometrik yapilari da istege göre farklilik gösterebilecegi gibi, tikanmanin minimize edilmesi için yuvarlak veya eliptik mikroporlar tercih edilmektedir. Behind the barrier tip(2) located at the end of the delivery catheter) Holes that provide continuous and preferably circular conduction on the delivery catheter[1] and/or micropores(3] with a diameter of microns. This section containing micropores[3] is preferably attached to the delivery catheter[1] of the barrier tip[2]. It starts from where it is connected and continues for 2 cm. However, the length here can be increased or decreased accordingly. This hole and/or micropores are preferably all over the delivery catheter. It is positioned to wrap around 3600 [degrees] on its circular surface. But only delivery Catheterine) in a suitable place above, next to or under it. is within the scope of this invention. Holes or preferably 100u-400p in diameter. sized these micropores[3] eliminate the forward embolizing agent transmission and It provides 360 degree radial transmission from the catheter[1] into the vein by sweating. Preferably Although it is recommended that the diameter of the micropores[3] be 300, the micropore[3] will be treated. It may vary according to the size of the vessel and the fluidity of the embolizing agent. Still Geometrical structures of micropores[3] or holes may also differ according to demand. For example, round or elliptical micropores are preferred to minimize clogging. is being done.
Girisim kateterinin(4) tercihen PTFE'den [politetrafloroetilenJ, üretilmesi önerilmektedir. It is suggested that the intervention catheter (4) is preferably manufactured from PTFE [polytetrafluoroethyleneJ.
Herhangi biyo-uyumlu ve yapinin bozulmasina izin vermeyecek derecede saglam bir maddeden de imal edilebilir. Any biocompatible and robust enough not to deteriorate the structure. It can also be made of material.
Bulus konusu bariyer uçlu teslim sisteminde öncelikle girisim kateteri tedavi edilecek damar içerisinde gönderilmekte ardindan girisim kateteri{4] içerisinden geçecek sekilde teslim kateteri(1) damar içerisine gönderilmektedir. Kateterler damar içerisine yerlestikten sonra embolizan ajan gönderilmek üzere kateterler tabancaya[12) baglanmaktadir. Tabancanin[12) tetigine[8) basildiginda embolizan ajan[13) teslim kateteri[1) içerisinden geçerek damara iletilmektedir. Bulus konusu bariyer uçlu embolizan ajan teslim sistemindeki teslim kateterinin[1] uç kisminda yer alan bariyer uç[2] ultrason ile gözlemlenmekte ve istenilen yere gelindiginde teslim kateterinin[1] durdurulmasi saglanmaktadir. Tedavi edilecek damarin ana arter ile birlestigi yere en yakin tedaviyi yapabilmek için bariyer uç(2] ultrasonla dikkatle takip edilmekte ve bariyer uçlu teslim sistemi sayesinde ana artere bariyer uç(2] boyutu kadar(1 cm veya daha küçük] yaklasilabilmektedir. Teslim kateterinin[1] konumu ayarlandiktan sonra tabancanin emniyeti(11) açilarak tetige[8] basilmakta ve embolizan ajan[13) teslim kateterini[1] takip ederek damara dogru ilerlemektedir. Teslim kateterininü) ucunda yer alan bariyer uca[2] gelindiginde ise yatay aktarim sona ermekte bariyer ucun(2) gerisinde, teslim kateteri(1) üzerinde yer alan delik ve/veya mikroporlardanß) damara embolizan ajan(13] yayilmaya baslamaktadir. Delik ve/Veya mikroporlar[3] tercihen teslim kateterininü] tüm yüzeyine yaygin oldugundan sadece bir noktadan degil pek çok farkli noktadan embolizan ajaninin[13) damara yayilmasini saglamaktadir. Bu sayede damarin sadece bir yüzeyine degil bütün yüzeyine ajan(13] temasi saglandigi gibi, ciddi komplikasyon olusturabilecek ana venin/arterin tikanmasi ve riskleri de engellenmektedir. Tabancanin tetigine(8) her basildiginda kateterlerde tabanca ile birlikte geri çekilmekte ve damar boyunca embolizan ajanin(13] aktarimi saglanmaktadir. Bulus konusu sistem temel olarak birbirinden ayri teslim[1] ve girisim kateteri(4) içermekle birlikte bu iki kateterin tek bir yapi altinda bütünlestirilerek, tümlesik tek bir kateterin bariyer uçlu ajan teslim sistemi olarak kullanilmasi da bu bulusun kapsami içerisindedir.In the barrier-tipped delivery system, which is the subject of the invention, the intervention catheter will be treated first. It is sent through the vein and then passes through the intervention catheter{4]. The delivery catheter (1) is sent into the vein. Catheters into the vein After placement, the catheters are inserted into the gun [12] to send the embolizing agent. is connecting. When the trigger[8) of the gun[12] is pressed, the embolizing agent[13] is delivered. It is transmitted to the vein by passing through the catheter [1]. Barrier-tipped embolizer, subject of the invention Barrier tip[2] ultrasound at the tip of the delivery catheter[1] in the agent delivery system It is observed with and when the desired location is reached, the delivery catheter[1] is stopped. is provided. The closest treatment to the junction of the vein to be treated with the main artery. Barrier tip(2) is carefully monitored by ultrasound and the barrier tip is delivered. Thanks to the system, the barrier tip(2) to the main artery is up to the size (1 cm or less] can be approached. After adjusting the delivery catheter[1] position, The safety (11) is opened and the trigger[8] is pressed and the embolizing agent[13] is followed by the delivery catheter[1]. It progresses towards the vein. The barrier at the tip of the delivery catheter[2] When it is reached, the horizontal transfer ends, and behind the barrier tip (2), the delivery catheter(1) the embolizing agent(13) into the vein(13) from the hole and/or micropores on the is starting. Hole and/or micropores[3] preferably over the entire surface of the delivery catheter Since it is common, it embolizes from many different points, not just from one point. It allows the agent[13] to spread into the vein. In this way, only one surface of the vessel As agent(13] contact is provided to its entire surface, it may cause serious complications. occlusion and risks of the main vein / artery are also prevented. The trigger(8) of the gun When pressed, the catheters are withdrawn with the gun and embolized along the vessel. transfer of agent(13) is provided.The inventive system is basically separate from each other. delivery[1] and intervention catheter(4), but these two catheters are under a single structure. as a barrier-tipped agent delivery system of an integrated single catheter. use is also within the scope of this invention.
Claims (1)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2016/18140A TR201618140A2 (en) | 2016-12-08 | 2016-12-08 | Barrier Tipped Embolizing Agent Delivery System |
| PCT/TR2017/050194 WO2018106202A1 (en) | 2016-12-08 | 2017-05-15 | Barrier-ended embolization agent delivery system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2016/18140A TR201618140A2 (en) | 2016-12-08 | 2016-12-08 | Barrier Tipped Embolizing Agent Delivery System |
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| TR201618140A2 true TR201618140A2 (en) | 2018-06-21 |
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| TR2016/18140A TR201618140A2 (en) | 2016-12-08 | 2016-12-08 | Barrier Tipped Embolizing Agent Delivery System |
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| AU2003265898A1 (en) * | 2002-09-05 | 2004-03-29 | Genentech, Inc. | Infusion catheter having an integrated doppler transducer |
| US9375223B2 (en) * | 2009-10-06 | 2016-06-28 | Cardioprolific Inc. | Methods and devices for endovascular therapy |
| US8992513B2 (en) * | 2011-06-30 | 2015-03-31 | Angiodynamics, Inc | Endovascular plasma treatment device and method of use |
| US8702678B2 (en) * | 2011-08-03 | 2014-04-22 | Venous Therapy, Inc. | Assemblies, systems, and methods for infusing therapeutic agents into the body |
| US9211372B2 (en) * | 2011-08-11 | 2015-12-15 | Osprey Medical, Inc. | Systems and methods for limb treatment |
| ES2843482T3 (en) * | 2012-04-24 | 2021-07-19 | Angioclinic Ag | Composition to treat venous insufficiency and varicose veins |
| JP2016519588A (en) * | 2013-03-15 | 2016-07-07 | アーセナル メディカル， インコーポレイテッド | System and method for aneurysm treatment |
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