TR201302590A2 - Synthesis of new compounds from diflunisal. - Google Patents

Synthesis of new compounds from diflunisal.

Info

Publication number
TR201302590A2
TR201302590A2 TR2013/02590A TR201302590A TR201302590A2 TR 201302590 A2 TR201302590 A2 TR 201302590A2 TR 2013/02590 A TR2013/02590 A TR 2013/02590A TR 201302590 A TR201302590 A TR 201302590A TR 201302590 A2 TR201302590 A2 TR 201302590A2
Authority
TR
Turkey
Prior art keywords
diflunisal
synthesis
new compounds
hydrazide
nsaei
Prior art date
Application number
TR2013/02590A
Other languages
Turkish (tr)
Inventor
Şenkardeş Sevi̇l
Güni̇z Küçükgüzel Ş
Original Assignee
S Gueniz Kuecuekguezel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S Gueniz Kuecuekguezel filed Critical S Gueniz Kuecuekguezel
Priority to TR2013/02590A priority Critical patent/TR201302590A2/en
Priority to PCT/TR2013/000114 priority patent/WO2014137301A1/en
Publication of TR201302590A2 publication Critical patent/TR201302590A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
    • C07C255/66—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bu buluşta, karboksilik asit yapısı içeren ve NSAEI bir ilaç etken maddesi olan Diflunisal'den hareketle elde edilen diflunisal hidrazitinin üzerinden antikanser , HCV-NS5B polimeraz ve DNA giraz enzim inhibisyonu etkisine sahip olabilecek orijinal diflunisal hidrazit-hidrazon ve 4-tiyazolidon yapısı içeren yeni bileşiklerin sentezlenmesi amaçlanmıştır.In the present invention, novel compounds comprising the carboxylic acid structure and the original diflunisal hydrazide-hydrazone and 4-thiazolidone structure which may have anticancer, HCV-NS5B polymerase and DNA gyrase enzyme inhibition action over diflunisal hydrazide obtained from Diflunisal, an NSAEI drug active ingredient. synthesis.

TR2013/02590A 2013-03-04 2013-03-04 Synthesis of new compounds from diflunisal. TR201302590A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TR2013/02590A TR201302590A2 (en) 2013-03-04 2013-03-04 Synthesis of new compounds from diflunisal.
PCT/TR2013/000114 WO2014137301A1 (en) 2013-03-04 2013-04-09 Hydrazones and thiazolidinones derived from diflunisal

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2013/02590A TR201302590A2 (en) 2013-03-04 2013-03-04 Synthesis of new compounds from diflunisal.

Publications (1)

Publication Number Publication Date
TR201302590A2 true TR201302590A2 (en) 2014-09-22

Family

ID=48325849

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2013/02590A TR201302590A2 (en) 2013-03-04 2013-03-04 Synthesis of new compounds from diflunisal.

Country Status (2)

Country Link
TR (1) TR201302590A2 (en)
WO (1) WO2014137301A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070107022A (en) * 2005-01-07 2007-11-06 신타 파마슈티칼스 코프. Compounds for inflammation and immune-related uses
US7649098B2 (en) * 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use

Also Published As

Publication number Publication date
WO2014137301A1 (en) 2014-09-12

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