TR200302268T4 - N-heterocyclic derivatives useful as NOS inhibitors. - Google Patents
N-heterocyclic derivatives useful as NOS inhibitors.Info
- Publication number
- TR200302268T4 TR200302268T4 TR2003/02268T TR200302268T TR200302268T4 TR 200302268 T4 TR200302268 T4 TR 200302268T4 TR 2003/02268 T TR2003/02268 T TR 2003/02268T TR 200302268 T TR200302268 T TR 200302268T TR 200302268 T4 TR200302268 T4 TR 200302268T4
- Authority
- TR
- Turkey
- Prior art keywords
- heterocyclic derivatives
- derivatives useful
- nos inhibitors
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
N-Heterocyclic derivatives selected from the group consisting of the following formulae:where Z1, Z2, Z3, R1, R2, R3, R4, R5 and R6 are described herein, are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19216800P | 2000-03-27 | 2000-03-27 | |
US09/814,787 US6525051B2 (en) | 2000-03-27 | 2001-03-22 | N-heterocyclic derivatives as NOS inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200302268T4 true TR200302268T4 (en) | 2004-01-21 |
Family
ID=26887800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2003/02268T TR200302268T4 (en) | 2000-03-27 | 2001-03-26 | N-heterocyclic derivatives useful as NOS inhibitors. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6525051B2 (en) |
EP (1) | EP1268471B1 (en) |
JP (1) | JP2003528871A (en) |
AT (1) | ATE252097T1 (en) |
AU (1) | AU2001245972A1 (en) |
DE (1) | DE60101000T2 (en) |
DK (1) | DK1268471T3 (en) |
ES (1) | ES2208578T3 (en) |
HK (1) | HK1053834A1 (en) |
NO (1) | NO20024614L (en) |
PT (1) | PT1268471E (en) |
TR (1) | TR200302268T4 (en) |
WO (1) | WO2001072744A1 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432947B1 (en) | 1997-02-19 | 2002-08-13 | Berlex Laboratories, Inc. | N-heterocyclic derivatives as NOS inhibitors |
US7012098B2 (en) * | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
IL162189A0 (en) * | 2001-11-30 | 2005-11-20 | Synta Pharmaceuticals Corp | Pyrimidine compounds |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
EP1795192A3 (en) * | 2002-04-30 | 2008-05-07 | Bayer Schering Pharma Aktiengesellschaft | 1-(Pyridazin-3-yl)-imidazole derivatives as inhibitors of nitric oxide synthase (NOS) |
US6982259B2 (en) * | 2002-04-30 | 2006-01-03 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
DK1534286T3 (en) | 2002-07-29 | 2010-04-26 | Rigel Pharmaceuticals Inc | Methods for treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
PL379330A1 (en) | 2002-12-20 | 2006-08-21 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
WO2005000404A2 (en) * | 2003-05-29 | 2005-01-06 | Synta Pharmaceuticals, Corp. | Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss |
PT1656372E (en) | 2003-07-30 | 2013-06-27 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
EP1758887A1 (en) | 2004-05-14 | 2007-03-07 | Pfizer Products Incorporated | Pyrimidine derivatives for the treatment of abnormal cell growth |
JP2007537235A (en) | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | Pyrimidine derivatives for the treatment of abnormal cell proliferation |
CA2566332A1 (en) | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
CA2571178A1 (en) * | 2004-07-01 | 2006-01-19 | Synta Pharmaceuticals Corp. | 2-substituted heteroaryl compounds |
US7557207B2 (en) | 2004-11-24 | 2009-07-07 | Rigel Pharmaceuticals, Inc. | Spiro 2,4-pyrimidinediamine compounds and their uses |
US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
EP2354126B1 (en) * | 2005-01-14 | 2013-09-25 | ChemoCentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
AU2006206458B2 (en) | 2005-01-19 | 2012-10-25 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
WO2007039578A1 (en) * | 2005-10-05 | 2007-04-12 | Nycomed Gmbh | Imidazolyl-substituted azabenzophenone compounds |
EP2146779B1 (en) | 2007-04-18 | 2016-08-10 | Pfizer Products Inc. | Sulfonyl amide derivatives for the treatment of abnormal cell growth |
ES2383568T3 (en) | 2007-07-12 | 2012-06-22 | Chemocentryx, Inc. | Heteroaryl pyridyl and phenyl benzenesulfonamides condensed as CCR2 modulators for the treatment of inflammation |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
MX2010011463A (en) * | 2008-04-16 | 2011-06-03 | Portola Pharm Inc | 2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or jak kinases inhibitors. |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
SI2300013T1 (en) | 2008-05-21 | 2018-03-30 | Adriad Pharmacaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
JP5999177B2 (en) | 2011-05-04 | 2016-09-28 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Compound for inhibiting cell proliferation of EGFR-activated cancer |
AU2012340555B2 (en) | 2011-11-23 | 2016-10-20 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
JP6469567B2 (en) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Compound for inhibiting cell proliferation of EGFR-activated cancer |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
IL266751B (en) | 2016-11-23 | 2022-07-01 | Chemocentryx Inc | Method of treating focal segmental glomerulosclerosis |
JP7301758B2 (en) * | 2017-03-13 | 2023-07-03 | インペティス・バイオサイエンシーズ・リミテッド | Fused bicyclic compounds, compositions and applications thereof |
AU2018347361A1 (en) | 2017-10-11 | 2020-04-30 | Chemocentryx, Inc. | Treatment of focal segmental glomerulosclerosis with CCR2 antagonists |
KR102563834B1 (en) * | 2021-06-28 | 2023-08-04 | 순천대학교 산학협력단 | Novel compound for inducing apoptosis and composition for anticancer comprising the same |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6339875A (en) | 1986-08-05 | 1988-02-20 | Nissin Food Prod Co Ltd | Pyrimidine derivative |
DE4118720A1 (en) | 1991-06-07 | 1992-12-10 | Bayer Ag | SUBSTITUTED IMIDAZOLINYLPYRIMIDINE |
AU665238B2 (en) | 1992-02-28 | 1995-12-21 | Zenyaku Kogyo Kabushiki Kaisha | S-triazine derivative and remedy for estrogen-dependent diseases containing the same as active ingredient |
US5593992A (en) | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
DK0640599T3 (en) | 1993-08-26 | 1998-09-28 | Ono Pharmaceutical Co | 4-aminopyrimidine derivatives |
US5426110A (en) | 1993-10-06 | 1995-06-20 | Eli Lilly And Company | Pyrimidinyl-glutamic acid derivatives |
AU4149696A (en) | 1994-11-15 | 1996-06-06 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
US5629322A (en) | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
EP0813525B9 (en) * | 1995-03-10 | 2004-02-04 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
DE19541146A1 (en) * | 1995-10-25 | 1997-04-30 | Schering Ag | Imidazole derivatives and their use as nitric oxide synthase inhibitors |
ZA977427B (en) | 1996-09-04 | 1998-03-02 | Dainippon Pharmaceutical Co | 2,4-disubstituted pyrimidine derivative, process for preparing the same, and a pharmaceutical composition containing the same. |
WO1998027108A2 (en) * | 1996-12-16 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds and their use as nitric oxide synthase inhibitors |
EP0968206B8 (en) | 1997-02-19 | 2007-01-24 | Berlex, Inc. | N-heterocyclic derivatives as nos inhibitors |
-
2001
- 2001-03-22 US US09/814,787 patent/US6525051B2/en not_active Expired - Fee Related
- 2001-03-26 TR TR2003/02268T patent/TR200302268T4/en unknown
- 2001-03-26 EP EP01918958A patent/EP1268471B1/en not_active Expired - Lifetime
- 2001-03-26 AU AU2001245972A patent/AU2001245972A1/en not_active Abandoned
- 2001-03-26 ES ES01918958T patent/ES2208578T3/en not_active Expired - Lifetime
- 2001-03-26 AT AT01918958T patent/ATE252097T1/en not_active IP Right Cessation
- 2001-03-26 DE DE60101000T patent/DE60101000T2/en not_active Expired - Lifetime
- 2001-03-26 JP JP2001570654A patent/JP2003528871A/en not_active Ceased
- 2001-03-26 PT PT01918958T patent/PT1268471E/en unknown
- 2001-03-26 DK DK01918958T patent/DK1268471T3/en active
- 2001-03-26 WO PCT/US2001/009481 patent/WO2001072744A1/en active IP Right Grant
-
2002
- 2002-09-26 NO NO20024614A patent/NO20024614L/en not_active Application Discontinuation
-
2003
- 2003-07-02 HK HK03104720.6A patent/HK1053834A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2001245972A1 (en) | 2001-10-08 |
NO20024614D0 (en) | 2002-09-26 |
DE60101000T2 (en) | 2004-07-29 |
EP1268471A1 (en) | 2003-01-02 |
EP1268471B1 (en) | 2003-10-15 |
ES2208578T3 (en) | 2004-06-16 |
PT1268471E (en) | 2004-03-31 |
DK1268471T3 (en) | 2004-02-09 |
US6525051B2 (en) | 2003-02-25 |
HK1053834A1 (en) | 2003-11-07 |
DE60101000D1 (en) | 2003-11-20 |
NO20024614L (en) | 2002-11-26 |
US20020010190A1 (en) | 2002-01-24 |
JP2003528871A (en) | 2003-09-30 |
ATE252097T1 (en) | 2003-11-15 |
WO2001072744A1 (en) | 2001-10-04 |
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