TR200100672T2 - New isoxazolinone antibacterial agents - Google Patents

New isoxazolinone antibacterial agents

Info

Publication number
TR200100672T2
TR200100672T2 TR2001/00672T TR200100672T TR200100672T2 TR 200100672 T2 TR200100672 T2 TR 200100672T2 TR 2001/00672 T TR2001/00672 T TR 2001/00672T TR 200100672 T TR200100672 T TR 200100672T TR 200100672 T2 TR200100672 T2 TR 200100672T2
Authority
TR
Turkey
Prior art keywords
new
antibacterial agents
isoxazolinone
isoxazolinone antibacterial
present
Prior art date
Application number
TR2001/00672T
Other languages
Turkish (tr)
Inventor
B. Snyder Lawrence
Zheng Zhizhen
Original Assignee
Bristol-Myers Souibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Souibb Company filed Critical Bristol-Myers Souibb Company
Publication of TR200100672T2 publication Critical patent/TR200100672T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Mevcut bulus, antibakteriyel aktiviteye sahip ve bakteriyel hastaliklarin tedavisinde faydali olan izoksazolinon türevleri ile ilgilidir. Özellikle, bulus konusu yeni izoksazolinonlar asagidaki genel formüle (I) sahip olacak biçimde saglanmakta olup içerisindeki A ve R1 tarifnamede tanimlanmaktadir.The present invention relates to isoxazolinone derivatives that have antibacterial activity and are useful in the treatment of bacterial diseases. In particular, the new isoxazolinones of the present invention are provided to have the general formula (I) below, and A and R1 are defined in the specification.

TR2001/00672T 1998-08-24 1999-08-23 New isoxazolinone antibacterial agents TR200100672T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9757498P 1998-08-24 1998-08-24

Publications (1)

Publication Number Publication Date
TR200100672T2 true TR200100672T2 (en) 2001-07-23

Family

ID=22264103

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00672T TR200100672T2 (en) 1998-08-24 1999-08-23 New isoxazolinone antibacterial agents

Country Status (22)

Country Link
EP (1) EP1107756A4 (en)
JP (1) JP2002523369A (en)
KR (1) KR20010072945A (en)
CN (1) CN1314813A (en)
AR (1) AR020250A1 (en)
AU (1) AU748750B2 (en)
BR (1) BR9913225A (en)
CA (1) CA2341271A1 (en)
CO (1) CO5160266A1 (en)
CZ (1) CZ2001669A3 (en)
HU (1) HUP0103433A3 (en)
ID (1) ID27690A (en)
IL (1) IL141542A0 (en)
NO (1) NO20010916L (en)
NZ (1) NZ509867A (en)
PE (1) PE20001063A1 (en)
PL (1) PL346267A1 (en)
TR (1) TR200100672T2 (en)
TW (1) TW572757B (en)
UY (1) UY25677A1 (en)
WO (1) WO2000010566A1 (en)
ZA (1) ZA200101505B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
JP2002020366A (en) * 2000-07-05 2002-01-23 Sumitomo Seika Chem Co Ltd Method for producing alkylthiophenylacetic acid
PE20020689A1 (en) 2000-11-17 2002-08-03 Upjohn Co OXAZOLIDINONES WITH A HETEROCYCLE OF 6 OR 7 MEMBERS UNITED WITH ANNULAR LINK TO BENZENE
PE20030044A1 (en) 2000-11-17 2003-02-09 Upjohn Co BICYCLE ISOXAZOLINONES OF FORMULA I
US6861433B2 (en) * 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
JP2004518677A (en) 2000-12-21 2004-06-24 ファルマシア・アンド・アップジョン・カンパニー Antibacterial quinolone derivatives and their use to treat bacterial infections
ES2180456B1 (en) * 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. SUBSTITUTED ISOXAZOLS AND ITS USE AS ANTIBIOTICS.
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2003035073A1 (en) 2001-10-25 2003-05-01 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
WO2004033449A1 (en) * 2002-10-10 2004-04-22 Pharmacia & Upjohn Company Llc Antimicrobial 1-aryl dihydropyridone compounds
JP2006516991A (en) * 2003-02-07 2006-07-13 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Antibacterial agent
DE602004014361D1 (en) 2003-04-30 2008-07-24 Morphochem Ag Komb Chemie USE OF OXAZOLIDINONE CHINOLIN HYBRID ANTIBIOTICS FOR THE TREATMENT OF ANTHRAX AND OTHER INFECTIONS
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
WO2005070904A2 (en) * 2003-06-03 2005-08-04 Rib-X Pharmaceutical, Inc. Sulfonamide compounds and methods of making and using the same
US6969726B2 (en) 2003-06-03 2005-11-29 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
WO2005012270A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same
DE10340485B4 (en) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Process for the preparation of oxazolidinone-quinolone hybrids
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
JP2007514782A (en) 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド Halogenated biaryl heterocyclic compounds and methods for making and using the same
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
ATE401326T1 (en) 2003-12-18 2008-08-15 Morphochem Ag Komb Chemie OXAZOLIDINONE-QUINOLONE HYBRID ANTIBIOTIC
WO2005082900A2 (en) * 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Oxazolidinone amidoximes as antibacterial agents
KR101394307B1 (en) 2005-06-08 2014-05-13 멜린타 테라퓨틱스, 인크. Process for the synthesis of triazoles
AT503354B1 (en) * 2006-02-22 2008-07-15 Dsm Fine Chem Austria Gmbh METHOD FOR THE PRODUCTION OF 3,4-DISUBSTITUTED PHENYL ACETIC ACIDS, AND NEW INTERMEDIATE COMPOUNDS
JP4518066B2 (en) * 2006-10-25 2010-08-04 宇部興産株式会社 Dialkoxynitrile derivative and process for producing the same
CN110423610B (en) * 2019-08-29 2023-05-12 浙江理工大学 Fluorescent probe for detecting two-photon mercury ions and preparation method and use method thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2045049A1 (en) * 1970-09-11 1972-03-23 Dr Karl Thomae GmbH, 7950 Biberach New Nitrofurandenvate and processes for their production
US4000155A (en) * 1975-12-11 1976-12-28 Eli Lilly And Company Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
ES2111188T3 (en) * 1992-12-08 1998-03-01 Upjohn Co ANTIBACTERIAL AGENTS DERIVED FROM PHENYLOXAZOLIDINONE SUBSTITUTED WITH TROPONE.
AU6902096A (en) * 1995-09-15 1997-04-01 Pharmacia & Upjohn Company 5-amidomethyl alpha, beta-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents
GB9521508D0 (en) * 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
PT920421E (en) * 1996-08-21 2003-03-31 Upjohn Co UTEIS ISOXAZOLINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Also Published As

Publication number Publication date
NO20010916D0 (en) 2001-02-23
CO5160266A1 (en) 2002-05-30
ID27690A (en) 2001-04-19
CN1314813A (en) 2001-09-26
WO2000010566A1 (en) 2000-03-02
AU748750B2 (en) 2002-06-13
AU5783399A (en) 2000-03-14
ZA200101505B (en) 2002-02-22
PE20001063A1 (en) 2000-12-24
UY25677A1 (en) 2001-08-27
HUP0103433A2 (en) 2002-01-28
CA2341271A1 (en) 2000-03-02
KR20010072945A (en) 2001-07-31
NO20010916L (en) 2001-04-10
PL346267A1 (en) 2002-01-28
AR020250A1 (en) 2002-05-02
BR9913225A (en) 2001-05-22
JP2002523369A (en) 2002-07-30
IL141542A0 (en) 2002-03-10
EP1107756A4 (en) 2003-02-26
NZ509867A (en) 2003-08-29
CZ2001669A3 (en) 2001-08-15
HUP0103433A3 (en) 2002-08-28
EP1107756A1 (en) 2001-06-20
TW572757B (en) 2004-01-21

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