TR200003570T2 - Mumbaistatin, Üretim yöntemi ve farmasötik kullanımı - Google Patents
Mumbaistatin, Üretim yöntemi ve farmasötik kullanımıInfo
- Publication number
- TR200003570T2 TR200003570T2 TR2000/03570T TR200003570T TR200003570T2 TR 200003570 T2 TR200003570 T2 TR 200003570T2 TR 2000/03570 T TR2000/03570 T TR 2000/03570T TR 200003570 T TR200003570 T TR 200003570T TR 200003570 T2 TR200003570 T2 TR 200003570T2
- Authority
- TR
- Turkey
- Prior art keywords
- mumbaistatin
- production method
- pharmaceutical use
- dsm
- pharmaceuticals
- Prior art date
Links
- XFESZXMDORIFAO-UHFFFAOYSA-N 1-[2-(5-carboxy-4-hydroxypentanoyl)-6-hydroxybenzoyl]-3,8-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid Chemical compound OC(=O)CC(O)CCC(=O)C1=CC=CC(O)=C1C(=O)C1=C(C(O)=O)C(O)=CC2=C1C(=O)C1=C(O)C=CC=C1C2=O XFESZXMDORIFAO-UHFFFAOYSA-N 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 102100039684 Glucose-6-phosphate exchanger SLC37A4 Human genes 0.000 abstract 1
- 101000886173 Homo sapiens Glucose-6-phosphate exchanger SLC37A4 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Mevcut bulus HIL-008003 (DSM 11641) mikroorganizmasinin kültürü vasitasiyla elde edilen Mumbaistatin adli bir bilesikle ve bu bilesigin farmasötik olarak uygun olan tuzlari ve türevleri ile ilgilidir. Mumbaistatin bir glikoz-6-fosfat translokaz önleyicisidir ve seker hastaliginin tedavisinde kullanilabilmektedir. Mevcut bulus ayrica Mumbaistatin'in üretimi için olan bir islem ile, HIL-008003 (DSM 11641) mikroorganizmasi ile, Mumbaistatin'in ve onun farmasötik olarak uygun olan tuzlarinin ve türevlerinin özellikle seker hastaliginin tedavisinde farmasötik maddeler olarak kullanilmalari ile ve Mumbaistatini ya da onun farmasötik olarak uygun olan bir tuzunu ya da türevini içeren farmasötik kompozisyonlar ile ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98111636 | 1998-06-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200003570T2 true TR200003570T2 (tr) | 2001-04-20 |
Family
ID=8232164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03570T TR200003570T2 (tr) | 1998-06-24 | 1999-06-15 | Mumbaistatin, Üretim yöntemi ve farmasötik kullanımı |
Country Status (17)
Country | Link |
---|---|
US (1) | US6297043B1 (tr) |
EP (1) | EP1090136B1 (tr) |
JP (1) | JP4287593B2 (tr) |
KR (1) | KR20010071564A (tr) |
CN (1) | CN1306580A (tr) |
AR (1) | AR020328A1 (tr) |
AT (1) | ATE328103T1 (tr) |
AU (1) | AU750509B2 (tr) |
BR (1) | BR9912200A (tr) |
CA (1) | CA2336135A1 (tr) |
DE (1) | DE69931633T2 (tr) |
HU (1) | HUP0102370A3 (tr) |
ID (1) | ID27411A (tr) |
PL (1) | PL345192A1 (tr) |
RU (1) | RU2221870C2 (tr) |
TR (1) | TR200003570T2 (tr) |
WO (1) | WO1999067408A1 (tr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001030736A2 (en) * | 1999-10-25 | 2001-05-03 | Aventis Pharma Deutschland Gmbh | Aromatic di-keto derivatives as glucose-6-phosphate translocase inhibitors |
ES2613277T3 (es) | 2001-02-21 | 2017-05-23 | Basf Enzymes Llc | Enzimas que tienen actividad de alfa amilasa y métodos de uso de las mismas. |
US7659102B2 (en) | 2001-02-21 | 2010-02-09 | Verenium Corporation | Amylases, nucleic acids encoding them and methods for making and using them |
US7741092B2 (en) | 2002-10-31 | 2010-06-22 | Verenium Corporation | Amylases, nucleic acids encoding them and methods for making and using them |
JP6465299B2 (ja) | 2015-05-29 | 2019-02-06 | 株式会社山田養蜂場本社 | 蜂蜜画分 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3905942A (en) | 1973-06-22 | 1975-09-16 | Gen Electric | Method for making polyetherimides and products produced thereby |
DE2429648A1 (de) * | 1973-06-22 | 1975-01-16 | Gen Electric | Verfahren zum herstellen von polyaetherimiden |
-
1999
- 1999-06-15 PL PL99345192A patent/PL345192A1/xx unknown
- 1999-06-15 HU HU0102370A patent/HUP0102370A3/hu unknown
- 1999-06-15 RU RU2001102052/13A patent/RU2221870C2/ru not_active IP Right Cessation
- 1999-06-15 JP JP2000556048A patent/JP4287593B2/ja not_active Expired - Fee Related
- 1999-06-15 AU AU45137/99A patent/AU750509B2/en not_active Ceased
- 1999-06-15 CN CN99807685A patent/CN1306580A/zh active Pending
- 1999-06-15 CA CA002336135A patent/CA2336135A1/en not_active Abandoned
- 1999-06-15 DE DE69931633T patent/DE69931633T2/de not_active Expired - Lifetime
- 1999-06-15 KR KR1020007014590A patent/KR20010071564A/ko not_active Application Discontinuation
- 1999-06-15 TR TR2000/03570T patent/TR200003570T2/tr unknown
- 1999-06-15 AT AT99927987T patent/ATE328103T1/de not_active IP Right Cessation
- 1999-06-15 WO PCT/EP1999/004127 patent/WO1999067408A1/en not_active Application Discontinuation
- 1999-06-15 ID IDW20002718A patent/ID27411A/id unknown
- 1999-06-15 BR BR9912200-6A patent/BR9912200A/pt not_active IP Right Cessation
- 1999-06-15 EP EP99927987A patent/EP1090136B1/en not_active Expired - Lifetime
- 1999-06-22 AR ARP990102990A patent/AR020328A1/es unknown
- 1999-06-23 US US09/338,601 patent/US6297043B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ID27411A (id) | 2001-04-05 |
CN1306580A (zh) | 2001-08-01 |
ATE328103T1 (de) | 2006-06-15 |
JP2002518057A (ja) | 2002-06-25 |
EP1090136B1 (en) | 2006-05-31 |
JP4287593B2 (ja) | 2009-07-01 |
EP1090136A1 (en) | 2001-04-11 |
AU4513799A (en) | 2000-01-10 |
BR9912200A (pt) | 2001-11-20 |
WO1999067408A1 (en) | 1999-12-29 |
AR020328A1 (es) | 2002-05-08 |
HUP0102370A2 (hu) | 2001-10-28 |
HUP0102370A3 (en) | 2003-10-28 |
CA2336135A1 (en) | 1999-12-29 |
KR20010071564A (ko) | 2001-07-28 |
AU750509B2 (en) | 2002-07-18 |
US6297043B1 (en) | 2001-10-02 |
DE69931633T2 (de) | 2007-05-10 |
PL345192A1 (en) | 2001-12-03 |
DE69931633D1 (de) | 2006-07-06 |
RU2221870C2 (ru) | 2004-01-20 |
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