TR200003333T2 - Benzothiophins useful in the treatment of insulin resistance and hyperglycemia - Google Patents

Benzothiophins useful in the treatment of insulin resistance and hyperglycemia

Info

Publication number
TR200003333T2
TR200003333T2 TR2000/03333T TR200003333T TR200003333T2 TR 200003333 T2 TR200003333 T2 TR 200003333T2 TR 2000/03333 T TR2000/03333 T TR 2000/03333T TR 200003333 T TR200003333 T TR 200003333T TR 200003333 T2 TR200003333 T2 TR 200003333T2
Authority
TR
Turkey
Prior art keywords
hyperglycemia
useful
treatment
insulin resistance
benzothiophins
Prior art date
Application number
TR2000/03333T
Other languages
Turkish (tr)
Inventor
Edward Wrobel Jay
Joan Dietrich Arlene
Miyoko Antane Madelene
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of TR200003333T2 publication Critical patent/TR200003333T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes

Abstract

Bu bulus,ensülin direngenligine veya hiperglisemiye bagli metabolik bozukluklarin tedavisinde yararli olan formül (I)'e iliskin bilesikleri saglamakta olup Ar burada (a), (b) veya (c)'dir. A,B,C,D,E,X,Y,Z1 ve Z2 burada tanim bölümünde tarif edildigi gibidir veya bunlarin farmakolojik olarak kabul edilebilir tuzlaridir.This invention provides compounds of formula (I) useful for the treatment of metabolic disorders due to insulin resistance or hyperglycemia, where Ar is (a), (b) or (c). A, B, C, D, E, X, Y, Z1 and Z2 are as described herein or their pharmacologically acceptable salts.

TR2000/03333T 1998-05-12 1999-05-10 Benzothiophins useful in the treatment of insulin resistance and hyperglycemia TR200003333T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7671298A 1998-05-12 1998-05-12

Publications (1)

Publication Number Publication Date
TR200003333T2 true TR200003333T2 (en) 2001-02-21

Family

ID=22133746

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03333T TR200003333T2 (en) 1998-05-12 1999-05-10 Benzothiophins useful in the treatment of insulin resistance and hyperglycemia

Country Status (22)

Country Link
EP (1) EP1077969A1 (en)
JP (1) JP2002516321A (en)
KR (1) KR20010043539A (en)
CN (1) CN1308626A (en)
AR (1) AR015294A1 (en)
AU (1) AU756337B2 (en)
BG (1) BG104918A (en)
BR (1) BR9911779A (en)
CA (1) CA2330620A1 (en)
EA (1) EA200001175A1 (en)
EE (1) EE200000653A (en)
HR (1) HRP20000767A2 (en)
HU (1) HUP0101792A3 (en)
ID (1) ID26244A (en)
IL (1) IL139132A0 (en)
NO (1) NO20005677L (en)
PL (1) PL344081A1 (en)
SK (1) SK16992000A3 (en)
TR (1) TR200003333T2 (en)
TW (1) TW510900B (en)
WO (1) WO1999061435A1 (en)
ZA (1) ZA200005961B (en)

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US20030055058A1 (en) * 2001-06-07 2003-03-20 Wyeth Combination of a PTPase inhibitor and an ACE inhibitor
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US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
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Also Published As

Publication number Publication date
IL139132A0 (en) 2001-11-25
EP1077969A1 (en) 2001-02-28
TW510900B (en) 2002-11-21
CA2330620A1 (en) 1999-12-02
AR015294A1 (en) 2001-04-18
HUP0101792A2 (en) 2002-01-28
HUP0101792A3 (en) 2003-01-28
PL344081A1 (en) 2001-09-24
NO20005677D0 (en) 2000-11-10
JP2002516321A (en) 2002-06-04
BR9911779A (en) 2001-02-06
ID26244A (en) 2000-12-07
CN1308626A (en) 2001-08-15
AU3893999A (en) 1999-12-13
WO1999061435A1 (en) 1999-12-02
AU756337B2 (en) 2003-01-09
HRP20000767A2 (en) 2001-10-31
ZA200005961B (en) 2001-10-24
BG104918A (en) 2001-08-31
KR20010043539A (en) 2001-05-25
EE200000653A (en) 2002-04-15
NO20005677L (en) 2000-12-05
EA200001175A1 (en) 2001-06-25
SK16992000A3 (en) 2001-04-09

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