TR199902455T2 - 5,7-Disebictie 4-Aminopyrido (2,3-D) Pyrimidine compounds and their use as adenosine kinase inhibitors - Google Patents
5,7-Disebictie 4-Aminopyrido (2,3-D) Pyrimidine compounds and their use as adenosine kinase inhibitorsInfo
- Publication number
- TR199902455T2 TR199902455T2 TR1999/02455T TR9902455T TR199902455T2 TR 199902455 T2 TR199902455 T2 TR 199902455T2 TR 1999/02455 T TR1999/02455 T TR 1999/02455T TR 9902455 T TR9902455 T TR 9902455T TR 199902455 T2 TR199902455 T2 TR 199902455T2
- Authority
- TR
- Turkey
- Prior art keywords
- adenosine kinase
- compound
- disebictie
- aminopyrido
- kinase inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Formül (I) e sahip bir bilesik tatbik ederek adenosin kinazi inhibe etmek içiin bir yöntem; burada R1,R2,R3 ve R4 tarifnamede tarif edildigi gibidir ve kesikli çizgi---ihtiyari bir çift bag bulundugunu belirtir; bu bilesigi içeren farmasötik terkip, ve tedaviye ihtiyaci olan bir memeliye bu bilesigin terapötik etkili bir miktarini vermek suretiyle, beyin iskemisi, epilepsi, agri duyarliligi, enflamasyon ve sepsisi tedavi etmek için bir yöntem; söz konusu bilesikleri hazirlamak için bir yöntem ve yukaridaki formüle sahip ve R1,R2,R3,ve R4 ün ayri ayri tanimlandigi bilesikler saglanmistir.A method for inhibiting adenosine kinase by applying a compound of formula (I); wherein R1, R2, R3 and R4 are as described in the specification, and the dotted line indicates that there is an optional double bond; pharmaceutical composition containing this compound, and a method of treating brain ischemia, epilepsy, pain sensitivity, inflammation and sepsis, by giving a mammal in need of treatment a therapeutically effective amount of this compound; A method for preparing said compounds and the formula above are provided, and compounds in which R1, R2, R3, and R4 are defined separately.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83821697A | 1997-04-16 | 1997-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199902455T2 true TR199902455T2 (en) | 2000-01-21 |
Family
ID=25276561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1999/02455T TR199902455T2 (en) | 1997-04-16 | 1998-04-14 | 5,7-Disebictie 4-Aminopyrido (2,3-D) Pyrimidine compounds and their use as adenosine kinase inhibitors |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0989986A1 (en) |
JP (1) | JP2001520655A (en) |
KR (1) | KR20010006509A (en) |
CN (1) | CN1252070A (en) |
AR (1) | AR012436A1 (en) |
AU (1) | AU7108398A (en) |
BG (1) | BG103842A (en) |
BR (1) | BR9809055A (en) |
CA (1) | CA2286909A1 (en) |
CO (1) | CO4940446A1 (en) |
HU (1) | HUP0001434A3 (en) |
IL (1) | IL131618A0 (en) |
NO (1) | NO995036D0 (en) |
PL (1) | PL336304A1 (en) |
SK (1) | SK141799A3 (en) |
TR (1) | TR199902455T2 (en) |
WO (1) | WO1998046605A1 (en) |
ZA (1) | ZA983177B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000023444A1 (en) * | 1998-10-21 | 2000-04-27 | Abbott Laboratories | 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
MXPA03007166A (en) | 2001-02-12 | 2003-11-18 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines. |
TW200406390A (en) | 2002-01-17 | 2004-05-01 | Neurogen Corp | Substituted quinazolin-4-ylamine analogues |
DE10335183A1 (en) * | 2003-07-30 | 2005-02-24 | Bayer Cropscience Ag | Fungicidal drug combinations |
ATE449097T1 (en) * | 2005-07-21 | 2009-12-15 | Hoffmann La Roche | PYRIDOÄ2,3-DÜPYRIMIDINE-2,4-DIAMINE COMPOUNDS AS PTPIB INHIBITORS |
WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
WO2007076034A2 (en) * | 2005-12-21 | 2007-07-05 | Abbott Laboratories | Anti-viral compounds |
EP2094276A4 (en) | 2006-12-20 | 2011-01-05 | Abbott Lab | Anti-viral compounds |
JP5718053B2 (en) | 2007-08-27 | 2015-05-13 | ヘリコン・セラピューティクス・インコーポレーテッド | Therapeutic isoxazole compounds |
CL2008002542A1 (en) | 2007-08-31 | 2009-01-02 | Eisai R&D Man Co Ltd | Imidazolyl pyridine derived compounds linked to a heterocycle via a vinyl, modulators of amyloid-beta activity; pharmaceutical composition comprising said compounds; and its use for the treatment of diseases such as Alzheimer's, dementia, Down syndrome or amyloidosis. |
DE102007061764A1 (en) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellated cyanopyridines and their use |
EP2401276B1 (en) * | 2009-02-26 | 2013-06-05 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
WO2014055595A1 (en) | 2012-10-05 | 2014-04-10 | Merck Sharp & Dohme Corp. | Indoline compounds as aldosterone synthase inhibitiors related applications |
ES2823190T3 (en) | 2016-03-31 | 2021-05-06 | Oncternal Therapeutics Inc | Indoline analogues and uses thereof |
CN110256420B (en) * | 2019-05-07 | 2020-04-28 | 江西中医药大学 | Tetrahydropyridopyrimidine derivatives, their preparation and use |
CN110283171A (en) * | 2019-07-17 | 2019-09-27 | 鼎泰(南京)临床医学研究有限公司 | Compound of the one kind containing Pyridopyrimidine -4- amine structure, pharmaceutical composition and its application |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324731A (en) * | 1989-02-14 | 1994-06-28 | Amira, Inc. | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated |
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
US6143749A (en) * | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
-
1998
- 1998-04-14 IL IL13161898A patent/IL131618A0/en unknown
- 1998-04-14 SK SK1417-99A patent/SK141799A3/en unknown
- 1998-04-14 KR KR1019997009599A patent/KR20010006509A/en not_active Application Discontinuation
- 1998-04-14 AU AU71083/98A patent/AU7108398A/en not_active Abandoned
- 1998-04-14 PL PL98336304A patent/PL336304A1/en unknown
- 1998-04-14 WO PCT/US1998/007207 patent/WO1998046605A1/en not_active Application Discontinuation
- 1998-04-14 CA CA002286909A patent/CA2286909A1/en not_active Abandoned
- 1998-04-14 TR TR1999/02455T patent/TR199902455T2/en unknown
- 1998-04-14 JP JP54408898A patent/JP2001520655A/en active Pending
- 1998-04-14 CN CN98804151A patent/CN1252070A/en active Pending
- 1998-04-14 HU HU0001434A patent/HUP0001434A3/en unknown
- 1998-04-14 BR BR9809055-0A patent/BR9809055A/en not_active Application Discontinuation
- 1998-04-14 EP EP98918093A patent/EP0989986A1/en not_active Withdrawn
- 1998-04-15 AR ARP980101733A patent/AR012436A1/en unknown
- 1998-04-15 ZA ZA983177A patent/ZA983177B/en unknown
- 1998-04-16 CO CO98020979A patent/CO4940446A1/en unknown
-
1999
- 1999-10-15 NO NO995036A patent/NO995036D0/en not_active Application Discontinuation
- 1999-10-29 BG BG103842A patent/BG103842A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
PL336304A1 (en) | 2000-06-19 |
SK141799A3 (en) | 2000-08-14 |
AR012436A1 (en) | 2000-10-18 |
HUP0001434A3 (en) | 2001-01-29 |
CN1252070A (en) | 2000-05-03 |
AU7108398A (en) | 1998-11-11 |
BR9809055A (en) | 2000-08-08 |
WO1998046605A1 (en) | 1998-10-22 |
CO4940446A1 (en) | 2000-07-24 |
IL131618A0 (en) | 2001-01-28 |
HUP0001434A2 (en) | 2000-10-28 |
NO995036L (en) | 1999-10-15 |
ZA983177B (en) | 1999-01-22 |
KR20010006509A (en) | 2001-01-26 |
NO995036D0 (en) | 1999-10-15 |
CA2286909A1 (en) | 1998-10-22 |
JP2001520655A (en) | 2001-10-30 |
EP0989986A1 (en) | 2000-04-05 |
BG103842A (en) | 2000-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR199902455T2 (en) | 5,7-Disebictie 4-Aminopyrido (2,3-D) Pyrimidine compounds and their use as adenosine kinase inhibitors | |
TR200002617T2 (en) | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas | |
TR200200749T2 (en) | Quinazoline compounds and pharmaceutical compositions containing them. | |
TR199701073T1 (en) | Protein kinase C inhibitors. | |
TR199801115T2 (en) | Kinazolin t�revleri. | |
TR200100694T2 (en) | 4,4-Biarylpiperidine derivatives with opioid receptor activity | |
TR200100047T2 (en) | Thiobenzimidazole derivatives | |
RU2694252C3 (en) | Derivatives of 4- (substituted phenylamino) quinazoline or their pharmaceutically acceptable salts, method for inhibiting receptor tyrosine kinase and pharmaceutical composition | |
TR199900827T2 (en) | Use of cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia. | |
GEP20053424B (en) | Pyrimidine-2,4,6-Trione Metalloproteinase Inhibitors | |
EE200200148A (en) | Quinazoline derivatives, methods for their preparation and their use | |
MX9702382A (en) | New pyrimidone derivatives with antifungal activity. | |
NO984470L (en) | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase | |
HUP0003982A3 (en) | The use of inhibitors of the renin-angiotensin system for producing pharmaceutical compositions using for the treatment of hypoxia or impaired metabolic function | |
ATE273281T1 (en) | HETEROCYCLIC CYTOTOXIC AGENTS | |
ATE269865T1 (en) | PYRAZOLO(3,4-G)QUINOXALINE AS PDGF RECEPTOR PROTEIN TYROSINE KINASE INHIBITORS | |
ES2184318T3 (en) | 6-SUBSTITUTED RENTALS. | |
PT1098885E (en) | IMIDAZOLE COMPOUNDS AND ITS USE AS ADENOSIN DISEASE DEHYMENASE INHIBITORS | |
BRPI0207102A8 (en) | crystalline form, pharmaceutical composition, and use of a crystalline form. | |
IS4725A (en) | Derivatives of amidine and isothio urea inhibit nitric oxide synthase | |
TR199902456T2 (en) | 6,7-ikameli-4-aminopyrido$2,3,-D]Pirimidin bile�ikleri. | |
AR035909A1 (en) | ESTERES OF ADENOSINE DERIVATIVES N6-OXA, -TIA, -TIOXA, AND SUBSTITUTED AZACICLOALQUILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT | |
BG105862A (en) | Light, extruded compositions containing a light, extrudable, ceramic carrier, methods for their use and preparartion | |
NO995035L (en) | 5,6,7-Trisubstituted-4-aminopyrido [2,3-D] pyrimidine Compounds | |
TR200003572T2 (en) | Cyanoiminoquinoxaline Derivatives |