TR199900712T2 - 1H-Pirido[3,4-b]indol-4-karboksamid türevleri, hazirlanmalari ve terapide uygulanmasi. - Google Patents

1H-Pirido[3,4-b]indol-4-karboksamid türevleri, hazirlanmalari ve terapide uygulanmasi.

Info

Publication number
TR199900712T2
TR199900712T2 TR1999/00712T TR9900712T TR199900712T2 TR 199900712 T2 TR199900712 T2 TR 199900712T2 TR 1999/00712 T TR1999/00712 T TR 1999/00712T TR 9900712 T TR9900712 T TR 9900712T TR 199900712 T2 TR199900712 T2 TR 199900712T2
Authority
TR
Turkey
Prior art keywords
group
therapy
alkyl
pirido
indole
Prior art date
Application number
TR1999/00712T
Other languages
English (en)
Inventor
Evanno Yannick
Sevrin Mireille
Maloizel Christian
Legalloudec Odette
George Pascal
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of TR199900712T2 publication Critical patent/TR199900712T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Mevcut bulus, içerisinde, X'in hidrojen veya bir halojeni veya bir alkil, alkoksi, triflorometil veya fenilmetoksi grubunu; R1'in hidrojen veya bir alkil, sayklopropil veya fenilmetil grubunu; R2'nin istege bagli olarak yeri degistirilen bir alkil grubunu veya fenilalkil grubunu, veya sayklohekzilmetil veya tienildimetil veya piridinilmetil veya fenil veya piridinil grubunu veya bir 5-metil-1,2-oksazolil veya 5-metil-1,3,4-tiadiazolil veya bir naftil grubunu; R3 ve R4'ün her birinin hidrojeni veya bir alkil grubunu, 2-metoksietil, hidroksialkil, karboksialkil, alkoksikarbonilalkil veya fenilalkil grubunu simgeledigi ya da pirolidinil, piperidinil grubunu veya morfolinil veya 4-metilpiperazinil veya azetidinil veya tiazolidinil grubunu olusturduklari genel formül (I)'deki bilesikler olup terapideki uygulamalarini içermektedir.(Formül(I)).
TR1999/00712T 1996-10-08 1997-10-03 1H-Pirido[3,4-b]indol-4-karboksamid türevleri, hazirlanmalari ve terapide uygulanmasi. TR199900712T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9612229A FR2754262B1 (fr) 1996-10-08 1996-10-08 Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
TR199900712T2 true TR199900712T2 (tr) 1999-06-21

Family

ID=9496449

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00712T TR199900712T2 (tr) 1996-10-08 1997-10-03 1H-Pirido[3,4-b]indol-4-karboksamid türevleri, hazirlanmalari ve terapide uygulanmasi.

Country Status (33)

Country Link
US (1) US6075021A (tr)
EP (1) EP0934319B1 (tr)
JP (1) JP4227197B2 (tr)
KR (1) KR100488095B1 (tr)
CN (1) CN1089765C (tr)
AR (1) AR009112A1 (tr)
AT (1) ATE218567T1 (tr)
AU (1) AU721102B2 (tr)
BG (1) BG63751B1 (tr)
BR (1) BR9711879A (tr)
CA (1) CA2266376A1 (tr)
CO (1) CO4910141A1 (tr)
CY (1) CY2291B1 (tr)
CZ (1) CZ298906B6 (tr)
DE (1) DE69713124T2 (tr)
DK (1) DK0934319T3 (tr)
EE (1) EE03830B1 (tr)
ES (1) ES2178008T3 (tr)
FR (1) FR2754262B1 (tr)
HK (1) HK1023338A1 (tr)
HU (1) HUP9904623A3 (tr)
IL (1) IL129018A0 (tr)
NO (1) NO311938B1 (tr)
NZ (1) NZ334708A (tr)
PL (1) PL188244B1 (tr)
PT (1) PT934319E (tr)
RU (1) RU2180904C2 (tr)
SK (1) SK282970B6 (tr)
TR (1) TR199900712T2 (tr)
TW (1) TW461889B (tr)
UA (1) UA57037C2 (tr)
WO (1) WO1998015552A1 (tr)
ZA (1) ZA978970B (tr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2833953B1 (fr) 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
MXPA05007563A (es) * 2003-01-27 2005-09-21 Pfizer Inhibidores de la integrasa del vih, composiciones farmaceuticas y metodos para su uso.
EP1756103A2 (en) * 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
ES2292123T3 (es) * 2004-04-26 2008-03-01 Pfizer Inc. Inhibidores de la enzima integrasa de vih.
KR20140002810A (ko) * 2005-05-05 2014-01-08 사노피-아벤티스 유.에스. 엘엘씨 안정한 나노입자 제형
EA200800758A1 (ru) * 2005-10-07 2008-08-29 Пфайзер Продактс Инк. Ингибиторы фермента интегразы вич
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
CN101460476B (zh) * 2006-06-05 2013-12-04 诺瓦提斯公司 有机化合物
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及***
KR100688448B1 (ko) * 2006-12-06 2007-03-02 (주)경진건축사사무소 건축물 내부 조적구조

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Also Published As

Publication number Publication date
EE03830B1 (et) 2002-08-15
NO991624D0 (no) 1999-04-06
CA2266376A1 (en) 1998-04-16
SK282970B6 (sk) 2003-01-09
JP2001508403A (ja) 2001-06-26
BR9711879A (pt) 1999-08-24
ATE218567T1 (de) 2002-06-15
ES2178008T3 (es) 2002-12-16
CO4910141A1 (es) 2000-04-24
EP0934319B1 (fr) 2002-06-05
RU2180904C2 (ru) 2002-03-27
SK45199A3 (en) 2000-02-14
AU721102B2 (en) 2000-06-22
BG63751B1 (bg) 2002-11-29
NZ334708A (en) 2000-10-27
DK0934319T3 (da) 2002-09-30
PL188244B1 (pl) 2005-01-31
AR009112A1 (es) 2000-03-08
PL332643A1 (en) 1999-09-27
NO311938B1 (no) 2002-02-18
FR2754262B1 (fr) 1998-10-30
CN1089765C (zh) 2002-08-28
HK1023338A1 (en) 2000-09-08
AU4559497A (en) 1998-05-05
PT934319E (pt) 2002-10-31
NO991624L (no) 1999-06-07
ZA978970B (en) 1998-04-20
DE69713124D1 (de) 2002-07-11
KR20000048992A (ko) 2000-07-25
FR2754262A1 (fr) 1998-04-10
KR100488095B1 (ko) 2005-05-09
EE9900155A (et) 1999-12-15
TW461889B (en) 2001-11-01
HUP9904623A3 (en) 2001-03-28
US6075021A (en) 2000-06-13
BG103301A (en) 2000-05-31
CZ119399A3 (cs) 1999-07-14
DE69713124T2 (de) 2003-01-30
JP4227197B2 (ja) 2009-02-18
CZ298906B6 (cs) 2008-03-12
IL129018A0 (en) 2000-02-17
CN1233248A (zh) 1999-10-27
UA57037C2 (uk) 2003-06-16
EP0934319A1 (fr) 1999-08-11
CY2291B1 (en) 2003-07-04
WO1998015552A1 (fr) 1998-04-16
HUP9904623A2 (hu) 2000-06-28

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