TR199501655A2 - Yeni monosiklik -laktam bilesikleri. - Google Patents

Yeni monosiklik -laktam bilesikleri.

Info

Publication number: TR199501655A2
Authority: TR; Turkey
Prior art keywords: lactam compounds; monocyclic; new; new monocyclic; lactam
Prior art date: 1994-12-22

Application number

TR95/01655A

Other languages

English (en)

Inventor

Deirdre Mary Bernadette Hickey

Dashyant Dhanak

Colin Andrew Leach

Robert John Ife

Graham Tew

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-22

Filing date

1995-12-22

Publication date

1996-07-21

1994-12-22 Priority claimed from GBGB9426020.5A external-priority patent/GB9426020D0/en

1994-12-23 Priority claimed from GBGB9426030.4A external-priority patent/GB9426030D0/en

1995-06-08 Priority claimed from GBGB9511599.4A external-priority patent/GB9511599D0/en

1995-06-08 Priority claimed from GBGB9511600.0A external-priority patent/GB9511600D0/en

1995-12-22 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1996-07-21 Publication of TR199501655A2 publication Critical patent/TR199501655A2/tr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TR95/01655A 1994-12-22 1995-12-22 Yeni monosiklik -laktam bilesikleri. TR199501655A2 (tr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9426020.5A GB9426020D0 (en)	1994-12-22	1994-12-22	Novel compounds
GBGB9426030.4A GB9426030D0 (en)	1994-12-23	1994-12-23	Novel compounds
GBGB9511599.4A GB9511599D0 (en)	1995-06-08	1995-06-08	Novel compounds
GBGB9511600.0A GB9511600D0 (en)	1995-06-08	1995-06-08	Novel compounds

Publications (1)

Publication Number	Publication Date
TR199501655A2 true TR199501655A2 (tr)	1996-07-21

Family

ID=27451242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR95/01655A TR199501655A2 (tr)	1994-12-22	1995-12-22	Yeni monosiklik -laktam bilesikleri.

Country Status (24)

Country	Link
US (1)	US5990102A (tr)
EP (1)	EP0799200A1 (tr)
JP (1)	JPH11500415A (tr)
CN (1)	CN1175246A (tr)
AP (1)	AP9701007A0 (tr)
AR (1)	AR002012A1 (tr)
AU (1)	AU704407B2 (tr)
BG (1)	BG101687A (tr)
BR (1)	BR9510420A (tr)
CA (1)	CA2208530A1 (tr)
CZ (1)	CZ192297A3 (tr)
DZ (1)	DZ1958A1 (tr)
FI (1)	FI972584A (tr)
HU (1)	HUT77089A (tr)
IL (1)	IL116485A0 (tr)
MA (1)	MA23834A1 (tr)
MX (1)	MX9704736A (tr)
NO (1)	NO972909L (tr)
NZ (1)	NZ298416A (tr)
OA (1)	OA10737A (tr)
PL (1)	PL320937A1 (tr)
SK (1)	SK80397A3 (tr)
TR (1)	TR199501655A2 (tr)
WO (1)	WO1996019451A1 (tr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997002242A1 (en) *	1995-07-01	1997-01-23	Smithkline Beecham Plc	Azetidinone derivatives for the treatment of atherosclerosis
JP2000502079A (ja) *	1995-12-08	2000-02-22	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	アテローム性動脈硬化症の治療のための単環β―ラクタム誘導体
EP0865429A1 (en) *	1995-12-08	1998-09-23	Smithkline Beecham Plc	Azetidinone compounds for the treatment of atherosclerosis
HUP9901359A3 (en) *	1996-04-26	2000-03-28	Smithkline Beecham Plc	Azetidinone derivatives for the treatment of atherosclerosis, process for their producing and pharmaceutical compositions containing them
GB9608649D0 (en) *	1996-04-26	1996-07-03	Smithkline Beecham Plc	Novel compounds
EP1099690A4 (en) *	1998-07-23	2001-10-17	Shionogi & Co	MONOCYCLIC BETA LACTAM COMPOUNDS AND CHYMASE INHIBITORS THAT CONTAIN THEM
WO2001060805A1 (en) *	2000-02-16	2001-08-23	Smithkline Beecham P.L.C.	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
GB0024808D0 (en)	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds
US6982251B2 (en) *	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
CA2517573C (en) *	2003-03-07	2011-12-06	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
JP4589919B2 (ja)	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US7235543B2 (en)	2003-03-07	2007-06-26	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2565387A1 (en) *	2004-05-03	2005-11-17	Ilypsa, Inc.	Modulation of lysophosphatidylcholine and treatment of diet-induced conditions
MX2009012188A (es)	2007-05-11	2010-02-24	Univ Jefferson	Métodos de tratamiento y prevención de enfermedades y desórdenes neurodegenerativos.
JP5437996B2 (ja)	2007-05-11	2014-03-12	ザトラスティーズオブザユニバーシティオブペンシルバニア	皮膚潰瘍の治療方法
US8962633B2 (en)	2007-05-11	2015-02-24	Thomas Jefferson University	Methods of treatment and prevention of metabolic bone diseases and disorders
JP5886310B2 (ja)	2010-12-06	2016-03-16	グラクソグループリミテッドＧｌａｘｏＧｒｏｕｐＬｉｍｉｔｅｄ	Ｌｐ−ＰＬＡ２により媒介される疾患または状態の処置における使用のためのピリミジノン化合物
EP2651403B1 (en)	2010-12-17	2020-12-02	Glaxo Group Limited	Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases
US20140171431A1 (en)	2011-06-27	2014-06-19	Jianhua Shen	Azole heterocyclic compound, preparation method, pharmaceutical composition and use
RU2014107484A (ru)	2011-07-27	2015-09-10	Глэксо Груп Лимитед	ПРИМЕНЕНИЕ СОЕДИНЕНИЙ 2,3-ДИГИДРОИМИДАЗО[1,2-с]ПИРИМИДИН-5(1H)-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ LP-PLA2
RU2014107486A (ru)	2011-07-27	2015-09-10	Глэксо Груп Лимитед	Бициклические пиримидоновые соединения
EP2948452B1 (en)	2013-01-25	2017-08-09	GlaxoSmithKline Intellectual Property Development Limited	2,3-dihydroimidazol[1,2-c]pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (lp-pla2) inhibitors
CN105008365B (zh)	2013-01-25	2017-03-15	葛兰素史密斯克莱知识产权发展有限公司	化合物
WO2014114249A1 (en)	2013-01-25	2014-07-31	Glaxosmithkline Intellectual Property Development Limited	Bicyclic pyrimidone compounds as inhibitors of lp-pla2
WO2015179293A1 (en) *	2014-05-18	2015-11-26	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Small molecule activators and inhibitors of lecithin: cholesterol acyltransferase
WO2016012916A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
AU2020379796C1 (en)	2019-11-09	2024-05-02	Shanghai SIMR Biotechnology Co., Ltd	Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof
CN115304620A (zh)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0010358A1 (en) *	1978-09-20	1980-04-30	Glaxo Group Limited	Beta-lactam compounds, processes for their preparation, compositions containing them, intermediates of use in their preparation and methods for the production thereof
US4680391A (en) *	1983-12-01	1987-07-14	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
IL99658A0 (en) *	1990-10-15	1992-08-18	Merck & Co Inc	Substituted azetidinones and pharmaceutical compositions containing them

1995
- 1995-12-20 CN CN95197606A patent/CN1175246A/zh active Pending
- 1995-12-20 MX MX9704736A patent/MX9704736A/es unknown
- 1995-12-20 WO PCT/EP1995/005130 patent/WO1996019451A1/en not_active Application Discontinuation
- 1995-12-20 BR BR9510420-8A patent/BR9510420A/pt unknown
- 1995-12-20 CA CA002208530A patent/CA2208530A1/en not_active Abandoned
- 1995-12-20 EP EP95942734A patent/EP0799200A1/en not_active Withdrawn
- 1995-12-20 AP APAP/P/1997/001007A patent/AP9701007A0/en unknown
- 1995-12-20 SK SK803-97A patent/SK80397A3/sk unknown
- 1995-12-20 NZ NZ298416A patent/NZ298416A/xx unknown
- 1995-12-20 US US08/860,162 patent/US5990102A/en not_active Expired - Fee Related
- 1995-12-20 DZ DZ950141A patent/DZ1958A1/fr active
- 1995-12-20 AR ARP950100660A patent/AR002012A1/es unknown
- 1995-12-20 PL PL95320937A patent/PL320937A1/xx unknown
- 1995-12-20 AU AU43898/96A patent/AU704407B2/en not_active Ceased
- 1995-12-20 MA MA24105A patent/MA23834A1/fr unknown
- 1995-12-20 CZ CZ971922A patent/CZ192297A3/cs unknown
- 1995-12-20 HU HU9701948A patent/HUT77089A/hu unknown
- 1995-12-20 JP JP8519527A patent/JPH11500415A/ja active Pending
- 1995-12-21 IL IL11648595A patent/IL116485A0/xx unknown
- 1995-12-22 TR TR95/01655A patent/TR199501655A2/tr unknown
1997
- 1997-06-17 FI FI972584A patent/FI972584A/fi unknown
- 1997-06-20 NO NO972909A patent/NO972909L/no unknown
- 1997-06-20 OA OA70034A patent/OA10737A/en unknown
- 1997-06-26 BG BG101687A patent/BG101687A/xx active Pending

Also Published As

Publication number	Publication date
AP9701007A0 (en)	1997-07-31
JPH11500415A (ja)	1999-01-12
HUT77089A (hu)	1998-03-02
MA23834A1 (fr)	1996-10-01
US5990102A (en)	1999-11-23
MX9704736A (es)	1997-10-31
SK80397A3 (en)	1998-01-14
IL116485A0 (en)	1996-08-04
AU4389896A (en)	1996-07-10
AR002012A1 (es)	1998-01-07
WO1996019451A1 (en)	1996-06-27
PL320937A1 (en)	1997-11-10
NZ298416A (en)	1999-03-29
NO972909D0 (no)	1997-06-20
FI972584A (fi)	1997-08-19
EP0799200A1 (en)	1997-10-08
OA10737A (en)	2002-12-10
AU704407B2 (en)	1999-04-22
BR9510420A (pt)	2004-04-20
CZ192297A3 (en)	1997-11-12
BG101687A (en)	1998-02-27
FI972584A0 (fi)	1997-06-17
NO972909L (no)	1997-08-20
DZ1958A1 (fr)	2002-02-17
CA2208530A1 (en)	1996-06-27
CN1175246A (zh)	1998-03-04

Publication	Publication Date	Title
TR199501597A2 (tr)	1996-07-21	Yeni bilesikler.
TR199600096A2 (tr)	1996-08-21	Yeni bilesikler.
TR199501655A2 (tr)	1996-07-21	Yeni monosiklik -laktam bilesikleri.
TR199501229A2 (tr)	1996-07-21	Yeni bilesim.
TR199700090A2 (tr)	1997-08-21	Yeni heteroaril-oksazolidinonlar.
FI951772A0 (fi)	1995-04-12	3,5-disubstituoidut tetrahydrofuran-2-onit
DE59507222D1 (de)	1999-12-16	Substituierte 1,2,3,4-tetrahydro-5-nitro-pyrimidine
ITRM950392A0 (it)	1995-06-13	Composti organici.
TR199500945A1 (tr)	1996-10-21	Sübstitüe edilmis bifeniloksazolinler.
TR199802626A3 (tr)	1999-10-21	Yeni farmasötikler.
TR199600778A2 (tr)	1997-04-22	Yeni sülfonamidler.
TR199501320A2 (tr)	1996-06-21	Anti- aritmik maddeler olarak faydali yeni bilesikler.
FI1592U1 (fi)	1994-10-26	Spruta, foeretraedesvis injektionsspruta
TR199501411A2 (tr)	1996-07-21	Kapaklar.
TR199501486A2 (tr)	1996-07-21	Yeni sülfonamidler.
TR26928A (tr)	1994-08-24	Yeni sogutucu bilesimler.
TR199500947A1 (tr)	1996-10-21	Yeni yüzeyaktif maddeler.
TR199501465A2 (tr)	1996-07-21	Yeni toksinler.
TR199500896A2 (tr)	1996-06-21	Yeni bilesik.
TR199500781A2 (tr)	1997-01-21	Yeni bilesik.
TR199501609A2 (tr)	1996-07-21	Yeni sulfonamidler.
TR199501608A2 (tr)	1996-07-21	Yeni sulfonamidler.
FR2720961B1 (fr)	1996-08-23	Baguetteuse.
IT234659Y1 (it)	2000-03-13	Sottosella.
FR2714950B3 (fr)	1996-06-28	Réducteur-variateur.