TN2014000104A1 - Aniline derivatives,their preparation and their therapeutic application - Google Patents

Aniline derivatives,their preparation and their therapeutic application

Info

Publication number
TN2014000104A1
TN2014000104A1 TNP2014000104A TN2014000104A TN2014000104A1 TN 2014000104 A1 TN2014000104 A1 TN 2014000104A1 TN P2014000104 A TNP2014000104 A TN P2014000104A TN 2014000104 A TN2014000104 A TN 2014000104A TN 2014000104 A1 TN2014000104 A1 TN 2014000104A1
Authority
TN
Tunisia
Prior art keywords
alkyl
preparation
therapeutic application
aniline derivatives
halogen
Prior art date
Application number
TNP2014000104A
Inventor
John Feutrill
Caroline Leriche
David Middlemiss
Original Assignee
Fovea Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/067473 external-priority patent/WO2013037705A2/en
Application filed by Fovea Pharmaceuticals filed Critical Fovea Pharmaceuticals
Publication of TN2014000104A1 publication Critical patent/TN2014000104A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom

Abstract

The present invention relates to aniline derivatives of formula (1), to their preparation and to their therapeutic application, for example in treating glaucoma: Formula (1), R1a represents H, an halogen, a (C1-Ca)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a(C1-Ca)alkyl; R2 represents H, an halogen, an OH, an O-(C1-Ca)alkyl or (C1-Ca)alkyl; R3 represents H, an halogen, a (C1-Ca)alkyl, an OH, an O-(C1-Ca)alkyl, a CONH2 or CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C1-C6)alkyl, or one of its enantiomers.
TNP2014000104A 2012-06-04 2014-03-11 Aniline derivatives,their preparation and their therapeutic application TN2014000104A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12305626 2012-06-04
PCT/EP2012/067473 WO2013037705A2 (en) 2011-09-16 2012-09-07 Aniline derivatives,their preparation and their therapeutic application

Publications (1)

Publication Number Publication Date
TN2014000104A1 true TN2014000104A1 (en) 2015-07-01

Family

ID=46331161

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2014000104A TN2014000104A1 (en) 2012-06-04 2014-03-11 Aniline derivatives,their preparation and their therapeutic application

Country Status (1)

Country Link
TN (1) TN2014000104A1 (en)

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