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Priority claimed from PCT/US2012/042174external-prioritypatent/WO2012174061A1/en
Application filed by Novartis AgfiledCriticalNovartis Ag
Publication of TN2013000494A1publicationCriticalpatent/TN2013000494A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The invention relates to a combination which comprises: (a) Compound A ((R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile) of Formula (A): [Chemical formula should be inserted here as it appears in Abstract in paper form] or a pharmaceutically acceptable salt thereof; and (b) Compound B (N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)-ethyl]-amino]methyl]phenyl]-2E-2-propenamide) of Formula (B): [Chemical formula should be inserted here as it appears in Abstract in paper form] or a pharmaceutically acceptable salt thereof; for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferative diseases. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating proliferative diseases, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.
TNP2013000494A2011-12-092013-11-25Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm
TN2013000494A1
(en)
Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquin oline derivatives, pharmaceutical compositions containing them, and their use in therapy.
N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy.