TN2010000418A1 - Crystalline forms and two solvated forms of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one lactic acid salts
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Crystalline forms and two solvated forms of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one lactic acid salts
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Priority claimed from PCT/EP2009/053222external-prioritypatent/WO2009115562A2/en
Application filed by Novartis AgfiledCriticalNovartis Ag
Publication of TN2010000418A1publicationCriticalpatent/TN2010000418A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Crystalline forms or polymorphs of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one lactic acid salts, as well as to methods of making the same, pharmaceutical compositions comprising the same and methods of treatment using the same.
TNP2010000418A2009-03-182010-09-08Crystalline forms and two solvated forms of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one lactic acid salts
TN2010000418A1
(en)
Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
Derivatives of 6-(6-substituted-triazolopyidazine-sulfanyl) 5-fluoro-benzothiazoles and 5-fluoro-benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors
Composition for treating or preventing diseases caused by vascular permeability, containing imatinib or pharmaceutically acceptable salt thereof as active ingredient
Compounds derived from 4- (2-oxo-1,2-dihydro-4-pyridinyl) -3-piperidine carboxamide; pharmaceutical composition; and use in the treatment or prophylaxis of diseases such as hypertension, congestive heart failure, pulmonary hypertension, atherosclerosis, among others.
Pharmaceutical salt of 1-cyclopropyl-8-methyl-7- [5-methyl-6- (methylamino) -3-pyridinyl] -4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; selected from citrate salt, hemifumarate, maleate, l-tartrate, mesylate, hydrochloride, potassium and sodium; pharmaceutical composition; and use to treat or prevent bacterial infections.