TH81786B - The derivative of the 5-substrate 7-amino- [1,3] thiazolo [4,5-D] new type of pyimidine - Google Patents
The derivative of the 5-substrate 7-amino- [1,3] thiazolo [4,5-D] new type of pyimidineInfo
- Publication number
- TH81786B TH81786B TH601001536A TH0601001536A TH81786B TH 81786 B TH81786 B TH 81786B TH 601001536 A TH601001536 A TH 601001536A TH 0601001536 A TH0601001536 A TH 0601001536A TH 81786 B TH81786 B TH 81786B
- Authority
- TH
- Thailand
- Prior art keywords
- formula
- pyimidine
- thiazolo
- derivative
- amino
- Prior art date
Links
- 239000000758 substrate Substances 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 239000011780 sodium chloride Substances 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000006673 Asthma Diseases 0.000 abstract 1
- 210000004556 Brain Anatomy 0.000 abstract 1
- 102100014440 CX3CR1 Human genes 0.000 abstract 1
- 101710039744 CX3CR1 Proteins 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 210000004351 Coronary Vessels Anatomy 0.000 abstract 1
- 208000009856 Lung Disease Diseases 0.000 abstract 1
- 210000000944 Nerve Tissue Anatomy 0.000 abstract 1
- 206010053643 Neurodegenerative disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 abstract 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 abstract 1
- 230000003042 antagnostic Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000001586 eradicative Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000002911 peripheral artery disease Diseases 0.000 abstract 1
- 230000001225 therapeutic Effects 0.000 abstract 1
Abstract
มีการเปิดเผยอนุพันธ์ของ 5-ซับสทิทิวเทด 7-อะมิโน-[1,3]ไธอะโซโล[4,5-D]พิริมิดีนชนิด ใหม่สูตร (I) (สูตรเคมี) (I) ซึ่ง R1, R2, R3, R4 และ R5 มีความหมายตามที่นิยามในรายละเอียดการประดิษฐ์, และเกลือที่ ยอมรับได้ทางเภสัชศาสตร์ของสารนั้น, พร้อมกับกรรมวิธีสำหรับการเตรียมสารเหล่านั้น, สารผสม ทางเภสัชศาสตร์ซึ่งประกอบรวมด้วยสารเหล่านั้น และการใช้สารเหล่านั้นในการรักษา สารประกอบ สูตร (I) เป็นแอนทาโกนิสท์ของตัวรับ CX3CR1 และดังนั้นจึงมีประโยชน์เป็นพิเศษในการรักษาหรือ ป้องกันความผิดปกติเกี่ยวกับการเสื่อมของประสาท, โรคเกี่ยวกับการขจัดไมอิลิน จากเนื้อเยื้อประสาท, ความผิดปกติเกี่ยวกับผนังของหลอดเลือดแดงใหญ่หนาขึ้นในหลอดเลือดหัวใจ และสมอง, โรคเกี่ยวกับหลอดเลือดแดงส่วนปลาย, ข้ออักเสบรูมาทอยด์, โรคเกี่ยวกับปอดเช่น COPD, หอบหืดหรืออาการปวด The derivative of 5- Substituted 7-amino- [1,3] thiazolo [4,5-D] new type of pyimidine, formula (I) (chemical formula) (I), where R1, R2, R3, R4 and R5 have The meaning as defined in the fabrication description, and the pharmacologically acceptable salts of those substances, along with the processes for their preparation, the pharmaceutical mixtures containing those substances. And their therapeutic use. Formula (I) is an antagonist of the CX3CR1 receptor and therefore is particularly useful in the treatment of or. Prevents neurodegenerative disorders, myelin eradication disease. From nerve tissue, aortic wall disorder, thickening in the coronary arteries and brain, peripheral artery disease, rheumatoid arthritis, pulmonary disease such as COPD, asthma, or pain.
Claims (2)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH81786A TH81786A (en) | 2006-12-14 |
| TH81786B true TH81786B (en) | 2006-12-14 |
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