TH172968A - Process and substance for drug preparation - Google Patents
Process and substance for drug preparationInfo
- Publication number
- TH172968A TH172968A TH1501005057A TH1501005057A TH172968A TH 172968 A TH172968 A TH 172968A TH 1501005057 A TH1501005057 A TH 1501005057A TH 1501005057 A TH1501005057 A TH 1501005057A TH 172968 A TH172968 A TH 172968A
- Authority
- TH
- Thailand
- Prior art keywords
- bruton
- substances
- tyrosine kinase
- compounds
- revealed
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 10
- 238000000034 method Methods 0.000 title claims abstract 4
- 239000003814 drug Substances 0.000 title claims abstract 3
- 229940079593 drugs Drugs 0.000 title claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 7
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 claims abstract 3
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 239000002177 L01XE27 - Ibrutinib Substances 0.000 claims abstract 2
- 230000015572 biosynthetic process Effects 0.000 claims abstract 2
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 claims abstract 2
- 229960001507 ibrutinib Drugs 0.000 claims abstract 2
- 238000003786 synthesis reaction Methods 0.000 claims abstract 2
- 230000002194 synthesizing Effects 0.000 claims abstract 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims abstract 2
- 229940121358 tyrosine kinase inhibitors Drugs 0.000 claims abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
Abstract
คำขอใหม่ปรับปรุงวันที่ 4/03/2559 สิ่งที่เปิดเผยคือ กระบวนการสำหรับการเตรียมสารประกอบดังต่อไปนี้ (สูตรเคมี) (I) (สุตรเคมี) (II) (I), (II) ที่ซึ่ง a1RR1 และ R2a มีการนิยามไว้ในรายละเอียดการประดิษฐ์ รวมทั้งกระบวนการ เพื่อเตรียมสารมัธยันตร์อื่นๆ ที่อาจจะมีประโยชน์ต่อการสังเคราะห์ผลิตภัณฑ์ปลายน้ำ โดยเฉพาะ อย่างยิ่งสารประกอบที่มีประโยชน์เป็นยา ตัวอย่างเช่น สารยับยั้งไทโรซีนไคเนสของ Bruton (Btk ,Bruton's tyrosine kinase) เช่นไอบรูทินิป (ibrutinib) นอกจากนั้นสิ่งที่เปิดเผยคือกระบวนการ .อื่นๆสารมัธยันตร์อื่นๆ และสารประกอบ ,โดยตรง: สิทธิบัตรยา New request updated 4/03/2016 What is revealed is The process for preparing the following compounds (Chemical Formula) (I) (Chemical) (II) (I), (II) where a1RR1 and R2a are defined in the invention details. Including the process To prepare other substances That may be useful for the synthesis of downstream products, especially pharmaceutical compounds, for example Bruton's tyrosine kinase inhibitors (Btk, Bruton's tyrosine kinase) such as ibrutinib. Then what is revealed is the process . Other substances and compounds, direct: drug patents.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH1501005057A TH1501005057A (en) | 2018-02-08 |
| TH172968A true TH172968A (en) | 2018-02-08 |
Family
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