TH120970B - Peptide vaccine for antigens involved in malignant tumors. - Google Patents
Peptide vaccine for antigens involved in malignant tumors.Info
- Publication number
- TH120970B TH120970B TH801000808A TH0801000808A TH120970B TH 120970 B TH120970 B TH 120970B TH 801000808 A TH801000808 A TH 801000808A TH 0801000808 A TH0801000808 A TH 0801000808A TH 120970 B TH120970 B TH 120970B
- Authority
- TH
- Thailand
- Prior art keywords
- peptides
- amino acid
- malignant tumors
- peptide vaccine
- antigens involved
- Prior art date
Links
- 201000011510 cancer Diseases 0.000 title abstract 2
- 229960005486 vaccines Drugs 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000038129 antigens Human genes 0.000 title 1
- 108091007172 antigens Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 8
- 150000001413 amino acids Chemical class 0.000 claims abstract 3
- 230000001939 inductive effect Effects 0.000 claims abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 102100005705 CDH15 Human genes 0.000 abstract 1
- 101710032686 CDH15 Proteins 0.000 abstract 1
- 101710035601 CDH3 Proteins 0.000 abstract 1
- 102100016307 ECT2 Human genes 0.000 abstract 1
- 101700000641 ECT2 Proteins 0.000 abstract 1
- 102100001720 EPHA4 Human genes 0.000 abstract 1
- 101710026872 EPHA4 Proteins 0.000 abstract 1
- 102100017182 HILPDA Human genes 0.000 abstract 1
- 101710037251 HILPDA Proteins 0.000 abstract 1
- 102100008237 INHBB Human genes 0.000 abstract 1
- 101700076660 INHBB Proteins 0.000 abstract 1
- 102100007848 KIF20A Human genes 0.000 abstract 1
- 101710038210 KIF20A Proteins 0.000 abstract 1
- 102100018415 NDC80 Human genes 0.000 abstract 1
- 101700049437 NDC80 Proteins 0.000 abstract 1
- 210000001744 T-Lymphocytes Anatomy 0.000 abstract 1
- 102100016802 TTK Human genes 0.000 abstract 1
- 101700079387 TTK Proteins 0.000 abstract 1
- 230000001472 cytotoxic Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drugs Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Abstract
การประดิษฐ์นี้จัดทำไว้ด้วยเปปไทด์ที่มีการเรียงตัวกรดอะมิโนที่ตั้งไว้ในการเรียงตัวที่ 19,22, 30,34,344,358,41,44,46,48,78,376,379,80,100,101,110,111,387,112,394, 114, 116,117,121,395,133,135,137,426,174,178,186,194,196,202,210,213,214,217 223,227,228,233,254,271,272 หรือ 288, รวมทั้งเปปไทด์ที่มีการเรียงตัวกรดอะมิโนที่กล่าวถึง ข้างต้นที่ซึ่งรวมถึงการที่ 1, 2 หรือหลายตัว (ได้ถึง 5 ตัว) ของกรดอะมิโนถูกแทนที่, หักออก หรือ ถูก เพิ่มไป, ที่ให้เปปไทด์ที่แสดงการเหนี่ยวนำเซลล์ T ที่เป็นพิษต่อเซลล์ได้ การประดิษฐ์นี้ได้จัดทำไว้ เช่นเดียวกันด้วยยาสำหรับการบำบัดรักษา หรือ ป้องกันโรคที่เกี่ยวข้องกับการแสดงออกที่มากของ CDH3,EPHA4,ECT2,HIG2,INHBB,KIF20A,KNTC2,TTK,และ/หรือ URLC10, กล่าวคือ มะเร็ง , ที่มีสารออกฤทธิ์เป็นตัวหนึ่ง หรือ มากกว่าของเปปไทด์เหล่านี้ เปปไทด์ของการประดิษฐ์นี้พบ ว่าใช้ได้ต่อไปเป็นวัคซีนได้: The invention is prepared with amino acid-stabilized peptides set in arrangements of 19,22, 30,34,344,358,41,44,46,48,78,376,379,80,100,101,110,111,387,112,394, 114, 116,117,121,395,133,135,137,426,174,178,186,194,196,202,210,213,214,217 223,227,228,233,254,271,272 or 288, including peptides with the amino acid-structured arrangement mentioned. This includes where 1, 2 or more (up to 5) of the amino acids are replaced, broken or added, that provide peptides showing the induction of T cells that are Cytotoxic This invention has prepared Likewise, with drugs for the treatment or prevention of diseases involving the extreme manifestation of CDH3, EPHA4, ECT2, HIG2, INHBB, KIF20A, KNTC2, TTK, and / or URLC10, i.e. cancer, containing one or more of these peptides. The peptide of this invention was found That it can continue to be used as a vaccine:
Claims (2)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH120970B true TH120970B (en) | 2013-02-14 |
| TH120970A TH120970A (en) | 2013-02-14 |
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