TH115252A - Process for preparing JAK inhibitors and related intermediate compounds. - Google Patents
Process for preparing JAK inhibitors and related intermediate compounds.Info
- Publication number
- TH115252A TH115252A TH1101001161A TH1101001161A TH115252A TH 115252 A TH115252 A TH 115252A TH 1101001161 A TH1101001161 A TH 1101001161A TH 1101001161 A TH1101001161 A TH 1101001161A TH 115252 A TH115252 A TH 115252A
- Authority
- TH
- Thailand
- Prior art keywords
- pyrimidines
- intermediate compounds
- diseases
- iii
- jak inhibitors
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 3
- 239000003112 inhibitor Substances 0.000 title claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 claims abstract 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract 4
- 150000003230 pyrimidines Chemical class 0.000 claims abstract 3
- 102000030951 Phosphotransferases Human genes 0.000 claims abstract 2
- 108091000081 Phosphotransferases Proteins 0.000 claims abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims abstract 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims abstract 2
- 210000000278 Spinal Cord Anatomy 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drugs Drugs 0.000 claims abstract 2
- 200000000018 inflammatory disease Diseases 0.000 claims abstract 2
- 230000035755 proliferation Effects 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- -1 Pyrazyl pyrimidines Chemical class 0.000 claims 1
- WLODWTPNUWYZKN-UHFFFAOYSA-N 1H-pyrrol-2-ol Chemical compound OC1=CC=CN1 WLODWTPNUWYZKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000005412 pyrazyl group Chemical group 0.000 abstract 1
Abstract
DC60 (14/07/54) การประดิษฐ์นี้เกี่ยวข้องกับกรรมวิธีสำหรับการเตรียมไพราโซลิล ไพรโรโล [2,3-d]ไพริมิดีนที่ถูกแทนที่ไครอล (chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines) ของสูตร III, และสารประกอบตัวกลางเชิงสังเคราะห์ที่เกี่ยวข้อง ไพราโซลิล ไพรโรโล[2,3-d]ไพริมิดีนที่ ถูกแทนที่ไครอลเป็นประโยชน์ในรูปตัวยับยั้งของเจนัส ไคเนส แฟมิลี่ของโปรตีน ไทโรซีนไคเนส (protein tyrosine kinases) (JAKs) สำหรับการรักษาของโรคที่มีการอักเสบ, ความผิดปกติ ของการเพิ่มจำนวนเซลล์ไขสันหลัง, และโรคอื่น ๆ (สูตรเคมี) III สิทธิบัตรยา DC60 (14/07/54) This invention involves a process for the preparation of pyrazolyl pyrrolo [2,3-d], chiral substituted pyrazolyl pyrrolo [2]. , 3-d pyrimidines) of formula III, and related synthetic intermediate compounds pyrazyl pyrrolol [2,3-d] pyrimidines at It is used as an inhibitor of the genus kinase family of protein tyrosine kinases (JAKs) for the treatment of inflammatory diseases, disorders. Of spinal cord proliferation, and other diseases (chemical formula) III drug patent
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH115252A true TH115252A (en) | 2012-07-31 |
| TH115252B TH115252B (en) | 2012-07-31 |
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