TH112183B - Cyclopropyl polymerase inhibitor - Google Patents
Cyclopropyl polymerase inhibitorInfo
- Publication number
- TH112183B TH112183B TH901002959A TH0901002959A TH112183B TH 112183 B TH112183 B TH 112183B TH 901002959 A TH901002959 A TH 901002959A TH 0901002959 A TH0901002959 A TH 0901002959A TH 112183 B TH112183 B TH 112183B
- Authority
- TH
- Thailand
- Prior art keywords
- hydrogen
- formula
- alkyl
- compound
- cyclopropyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 12
- 239000001257 hydrogen Substances 0.000 claims abstract 12
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims abstract 9
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 2
- 101700040785 CHR5 Proteins 0.000 claims abstract 2
- 229920000388 Polyphosphate Polymers 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- -1 tri-phosphate ester Chemical class 0.000 claims abstract 2
- 235000011178 triphosphate Nutrition 0.000 claims abstract 2
- 239000001226 triphosphate Substances 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Abstract
สารประกอบสูตร I (สูตร) ซึ่ง R2 คือไฮโดรเจนหรือ C1-C4 แอลคิล, R3 และ R4 คือไฮโดรเจน, -C(=O)R5, หรือ -C(=O)CHR6-NH2; หรือ R3 คือไฮโดรเจน และ R4 คือโมโนฟอสเฟท-, ไดฟอสเฟท-, หรือไทรฟอสเฟท เอสเทอร์, หรือ R3 คือไฮโดรเจน, -C(=O)CHR5, หรือ -C(=O)CHR6-NH2 และ R4 คือ (สูตร) R5 แต่ละหมู่ คือไฮโดรเจน, C1-C6แอลคิล, หรือ C3-C7ไซโคลแอลคิล, R6 คือไฮโดรเจนหรือ C1-C6แอลคิล, เลือกแทนที่ R7 ด้วยฟีนิล, แนฟธิล, หรืออินโดลิล R8 และ R8 คือไฮโดรเจน, C1-C6แอลคิล, เบนซิล, หรือ R8 และ R8 ร่วมกันก่อรูปเป็น C3-C7ไซโคลแอลคิล, R9 คือ C1-C6แอลคิล, เบนซิล, หรือ เลือกคือ ฟีนิลที่ถูกแทนที่ โดยมีเงื่อนไขว่า R2, R3 และ R4 ทั้งหมดไม่ใช่ไฮโดรเจน หรือเกลือ ซึ่งเป็นทียอมรับในทางเภสัชกรรม หรือโซลเวทของสารนั้น, สูตรทางเภสัชศาสตร์ที่มีสารประกอบ I, การใช้สารประกอบ I, ซึ่งรวมถึงสารประกอบสูตร I ซึ่ง R2, R3 และ R4 ทั้งหมดคือไฮโดรเจน, ซึ่งเป็นสารยับยั้ง HCV Compound formula I (formula) where R2 is hydrogen or C1-C4 alkyl, R3 and R4 is hydrogen, -C (= O) R5, or -C (= O) CHR6-NH2; Or R3 is hydrogen and R4 is monophosphate-, diffosphate-, or tri-phosphate ester, or R3 is hydrogen, -C (= O) CHR5, or -C (= O) CHR6-NH2 and R4 are (formula) R5, each group is hydrogen, C1-C6 alkyl, or C3-C7 cycloalkyl, R6 is hydrogen or C1-C6 alkyl. R8, choose to replace R7 with phenyl, naphthyl, or indole R8 and R8 are hydrogen, C1-C6 alkyl, benzyl, or R8 and R8. C3-C7 cycloalkyl, R9 is C1-C6 alkyl, benzyl, or optionally is the substituted phenyl. Provided that all R2, R3 and R4 are not hydrogen or salt, which is acceptable for pharmaceutical purpose. Or the solvate of that substance, the pharmaceutical formula with compound I, the use of compound I, which includes the compound formula I where R2, R3 and R4 all are hydrogen, which is an HCV inhibitor
Claims (1)
Publications (2)
Publication Number | Publication Date |
---|---|
TH112183A TH112183A (en) | 2012-02-15 |
TH112183B true TH112183B (en) | 2012-02-15 |
Family
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