TH101974B - Substituted pyrazolo-quinazoline derivatives, the process for their preparation and their use as a kinase inhibitor. - Google Patents
Substituted pyrazolo-quinazoline derivatives, the process for their preparation and their use as a kinase inhibitor.Info
- Publication number
- TH101974B TH101974B TH701006392A TH0701006392A TH101974B TH 101974 B TH101974 B TH 101974B TH 701006392 A TH701006392 A TH 701006392A TH 0701006392 A TH0701006392 A TH 0701006392A TH 101974 B TH101974 B TH 101974B
- Authority
- TH
- Thailand
- Prior art keywords
- preparation
- kinase inhibitor
- quinazoline derivatives
- substituted pyrazolo
- same
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- GNOYRJIXSUNXIH-UHFFFAOYSA-N N1=CNC2=C3C=NN=C3C=CC2=C1 Chemical class N1=CNC2=C3C=NN=C3C=CC2=C1 GNOYRJIXSUNXIH-UHFFFAOYSA-N 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 238000006073 displacement reaction Methods 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 102000030951 Phosphotransferases Human genes 0.000 abstract 1
- 108091000081 Phosphotransferases Proteins 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N Quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000005426 pharmaceutical component Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 230000001225 therapeutic Effects 0.000 abstract 1
Abstract
อนุพันธ์ไพราโซโล+ควินาโซลีนของสูตรที่ (I) เหมือนกับที่กำหนดเอาไว้ในบท บรรยายรายละเอียด และเกลือที่สามารถยอมรับได้ทางเภสัชกรรม กระบวนการสำหรับการเตรียม และ องค์ประกอบทางเภสัชกรรมซึ่งประกอบด้วยสารเหล่านั้นถูกเปิดเผย สารประกอบของการประดิษฐ์ อาจจะมีประโยชน์ ทางการบำบัดรักษา ในการรักษาโรคที่เกี่ยวกับการออกฤทธิ์โปรตีน ไคเนสที่สูญเสีย การควบคุมเหมือนกับโรคมะเร็ง The pyrazolo derivative + quinazoline of formula (I) is the same as that given in chapter Detailed description And pharmaceutical salts The process for the preparation and the pharmaceutical components which comprise them are disclosed. Fabrication compound May be useful Therapeutic In the treatment of disease Lost kinase Control is the same as cancer.
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH101974A TH101974A (en) | 2010-06-25 |
| TH101974B true TH101974B (en) | 2010-06-25 |
Family
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