SV2002000205A - PHARMACEUTICAL COMPOUNDS REF. X-01095 - Google Patents

PHARMACEUTICAL COMPOUNDS REF. X-01095

Info

Publication number
SV2002000205A
SV2002000205A SV2000000205A SV2000000205A SV2002000205A SV 2002000205 A SV2002000205 A SV 2002000205A SV 2000000205 A SV2000000205 A SV 2000000205A SV 2000000205 A SV2000000205 A SV 2000000205A SV 2002000205 A SV2002000205 A SV 2002000205A
Authority
SV
El Salvador
Prior art keywords
derivatives
pyrimidine
pharmaceutical compounds
substituted
compounds ref
Prior art date
Application number
SV2000000205A
Other languages
Spanish (es)
Inventor
Samantha Jayne Ambler
Stephen Richard Baker
Kirk Willis Johnson
Ann Elizabeth Kingston
Barry Peter Clark
Darrell Stephen Coleman
Robert James Foglesong
Junior Gunnar Erik Jagdmann
Darryle Darwin Schoepp
Jian Eric Hong
Jeffrey Michael Schkeryantz
Michael Scott Vannieuwenhze
Mohammad Sadegh Zia-Ebrahimi
John Goldsworthy
William Martin Owton
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SV2002000205A publication Critical patent/SV2002000205A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

LA PRESENTE INVENCION SE REFIERE AL USO DE CIERTOS DERIVADOS 4-SUSTITUIDOS DE LA PIRIMIDINA COMO ANTAGONISTAS DE LOS RECEPTORES mGLuR1, A NUEVOS DERIVADOS 4-SUSTITUIDOS DE LA PIRIMIDINA, A FORMULACIONES FARMACEUTICAS QUE COMPRENDEN DERIVADOS 4-SUSTITUIDOS DE LA PIRIMIDINA, A UN PROCEDIMIENTO PARA PREPARAR DERIVADOS 4-SUSTITUIDOS DE LA PIRIMIDINA Y A INTERMEDIOS UTILES EN LA PREPARACION DE DERIVADOS 4-SUSTITUIDOS DE LA PIRIMIDINA.THE PRESENT INVENTION CONCERNS THE USE OF CERTAIN 4-SUBSTITUTED DERIVATIVES OF PYRIMIDINE AS ANTAGONISTS OF MGLURR1 RECEPTORS, TO NEW 4-SUBSTITUTED DERIVATIVES OF PYRIMIDINE, TO PHARMACEUTICAL FORMULATIONS THAT INCLUDE DERIVATIVES OF THE UNIT 4-SUBSTITUTE PREPARE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES AND ALREADY INTERMEDIATE IN THE PREPARATION OF 4-REPLACED PYRIMIDINE DERIVATIVES.

SV2000000205A 1999-11-01 2000-10-19 PHARMACEUTICAL COMPOUNDS REF. X-01095 SV2002000205A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16290099P 1999-11-01 1999-11-01

Publications (1)

Publication Number Publication Date
SV2002000205A true SV2002000205A (en) 2002-06-07

Family

ID=22587589

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2000000205A SV2002000205A (en) 1999-11-01 2000-10-19 PHARMACEUTICAL COMPOUNDS REF. X-01095

Country Status (7)

Country Link
EP (1) EP1230225A2 (en)
AR (1) AR026275A1 (en)
AU (1) AU1071301A (en)
CO (1) CO5261605A1 (en)
PE (1) PE20010854A1 (en)
SV (1) SV2002000205A (en)
WO (1) WO2001032632A2 (en)

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Also Published As

Publication number Publication date
PE20010854A1 (en) 2001-08-28
AR026275A1 (en) 2003-02-05
WO2001032632A3 (en) 2001-11-08
CO5261605A1 (en) 2003-03-31
WO2001032632A2 (en) 2001-05-10
AU1071301A (en) 2001-05-14
EP1230225A2 (en) 2002-08-14

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