SU687069A1 - Method of obtaining substituted 1-acylthiosemicarbazides - Google Patents

Method of obtaining substituted 1-acylthiosemicarbazides

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Publication number
SU687069A1
SU687069A1 SU711658626A SU1658626A SU687069A1 SU 687069 A1 SU687069 A1 SU 687069A1 SU 711658626 A SU711658626 A SU 711658626A SU 1658626 A SU1658626 A SU 1658626A SU 687069 A1 SU687069 A1 SU 687069A1
Authority
SU
USSR - Soviet Union
Prior art keywords
yield
cyclic
bis
phenylthiosemicarbazide
general formula
Prior art date
Application number
SU711658626A
Other languages
Russian (ru)
Inventor
Шварц Юстус
Юст Хельмут
Original Assignee
Феб Берлин-Хеми (Инопредприятие)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Феб Берлин-Хеми (Инопредприятие) filed Critical Феб Берлин-Хеми (Инопредприятие)
Application granted granted Critical
Publication of SU687069A1 publication Critical patent/SU687069A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Claims (1)

(54) СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ 1-ЙЦИЛТИОСЕМИКАРБАЗИДОВ -4-фенилтиосемикарбазида, выход 11 ( 884К т.пл. 153-154С (из этанола В аналогичных услови х получают 1-(4-хлорфенсжсиацетил)-4-фенилтио микарбазид, выход 91%, т.пл. i92C 1-бенэоил-4-(нафтил-2)тиосемикарба эид, вьрсод 93%, Т..ПЛ. Г- (4-хлорфеноксиацетил)-4-(нафтил тиосемикарбаэид, выход 95%, т.пл. 170С; 1-адг1мантоил-4-циклогексилтиосеми карбазид, выход 89%, т.пл. 234С; 1-циннамоил-4-бутилтиосемикарба .зид, выход 64%г т.пл. малонил-бис-(4-циклогексилтиосемикарбазид ), выход 81%, т.пл. 203 сукцинил-бис- 4-(4-хлорфенил)тиосемикарбазид , выход 92%, т.пл. 182ТС; сут цинил-бис-(4-фенилтиосемикарбазид , выход 92%, т.пл. 1бЗе; с кцинил-бис-(4-бензилтиосемикарбазид ), выход 91%f т.пл. 1-(4-нитробензоил)-4-циклогексилтиосемикарбазид , выход 40%, т.пл. . Формула изобретени  Способ получени  Зс1мещенных 1-ацилтиосемикарбазидов общей фор мулы R CONHNHCSNHRj фенил, 4-хлорфенил, циклогексил, бензил, нафтил, или бутил; 4-нитрофенил, стирил, адамантил, 4-хлорфеноксиметил , фенил, карбэтоксигруппа или группа общей формулы R NHCSNHNHCO(CH)  где имеет указанные значени ; О, 1, 2, о т л иющийс  тем, что, соеди-ие общей формулы RZ CONHNH где Rj принимает все значени  ме значени  R NHCSNHNHCO (СН;} )„ , или представл ет собой группу общей (снр„ где п имеет указанные значени , вергают взаимодействию с изотио- натом общей формулы ftjjNCS где RI имеет указанные значени . Источники.информации, н тые во внимание при экспертизе1 . Male Ili«, Comanila Eugenia, Syntere О1 ac)l-thiosemicarbazide si semicarba . Nola 1. Bui. Tnel. Polltehn. Tasi, 6, 12, 189.(54) METHOD FOR OBTAINING SUBSTITUTED 1-YCILTHIOSEMICARBAZIDES-4-phenylthiosemicarbazide, yield 11 (884K, mp 153-154 ° C (from ethanol, 1- (4-chlorfensgexyacetyl) -4-phenylthio-myc- chycricacyricacycid-caccic-cyclic-cyclic-cyclic-cyclic-cyclic-cyclic-acetylene) -4-phenylthiosemicarbazide) mp i92C 1-beneoyl-4- (naphthyl-2) thiosemicarba aeid, varsod 93%, T.PL.H- (4-chlorophenoxyacetyl) -4- (naphthyl thiosemicarbaide, 95% yield, mp. 170C; 1-adg1mantoyl-4-cyclohexylthiosemia carbazide, yield 89%, mp 234C; 1-cinnamoyl-4-butylthiosemicarba .zid, yield 64% g mp. Malonyl bis (4-cyclohexylthiosemicarbazide), yield 81%, mp. 203 succinyl-bis- 4- (4-chlorophenyl) thiosemicarbazide , yield 92%, mp. 182TC; day cylin-bis- (4-phenylthiosemicarbazide, yield 92%, mp. 1bZe; with ktsynil-bis- (4-benzylthiosemicarbazide), yield 91% f so pl. 1- (4-nitrobenzoyl) -4-cyclohexylthiosemicarbazide, yield 40%, mp. Formula of the invention. -nitrophenyl, styryl, adamantyl, 4-chlorophenoxymethyl, phenyl, carbethoxy group, or a group of the general formula R, NHCSNHNHCO (CH), where it has the indicated meanings; O, 1, 2, that is, a compound of the general formula RZ CONHNH where Rj takes all values of R NHCSNHNHCO (СН;}) ", or is a total group (snr where n has the indicated the values relate to the interaction with the isothionate of the general formula ftjjNCS where RI has the indicated values. Sources. Information taken into account in the examination 1. Male Ili ", Comanila Eugenia, Syntere O1 ac) l-thiosemicarbazide si semicarba. Nola 1. Bui. Tnel. Polltehn. Tasi, 6, 12, 189.
SU711658626A 1970-07-14 1971-05-18 Method of obtaining substituted 1-acylthiosemicarbazides SU687069A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD14880370 1970-07-14

Publications (1)

Publication Number Publication Date
SU687069A1 true SU687069A1 (en) 1979-09-25

Family

ID=5482717

Family Applications (2)

Application Number Title Priority Date Filing Date
SU711658626A SU687069A1 (en) 1970-07-14 1971-05-18 Method of obtaining substituted 1-acylthiosemicarbazides
SU1841244A SU461095A1 (en) 1970-07-14 1971-05-18 Method for preparing substituted 1-acylthiosemicarbazides

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU1841244A SU461095A1 (en) 1970-07-14 1971-05-18 Method for preparing substituted 1-acylthiosemicarbazides

Country Status (5)

Country Link
CH (2) CH547787A (en)
DE (1) DE2126304C3 (en)
FR (1) FR2097737A5 (en)
HU (2) HU164570B (en)
SU (2) SU687069A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2475478C2 (en) * 2006-08-21 2013-02-20 Синта Фармасьютиклз Корп. Compounds for treatment of proliferative disorders

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134914A (en) * 1975-08-25 1979-01-16 Eli Lilly And Company 1-Acyl-4-substituted phenyl thiosemicarbazides
GR69827B (en) * 1978-09-14 1982-07-13 Gulf Oil Corp
US4405791A (en) * 1979-12-10 1983-09-20 Gulf Oil Corporation Arylthioureido pyridinecarbamino compounds and use as plant growth regulants
WO1989006125A1 (en) * 1987-12-31 1989-07-13 Smithkline Beckman Corporation 4-aralkyl-5-substituted-1,2,4-triazole-5-thiols
TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
US6924312B2 (en) 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
CN1993318B (en) 2004-06-23 2012-10-03 Synta医药公司 Bis(thio-hydrazide amide) salts for treatment of cancers
JP5204489B2 (en) 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Bis (thio-hydrazide amide) to increase HSP70 expression
JP2008536875A (en) 2005-04-15 2008-09-11 シンタ ファーマシューティカルズ コーポレーション Combined cancer therapy with bis (thiohydrazide) amide compounds
EP1888520A2 (en) 2005-05-16 2008-02-20 Synta Pharmaceuticals Corporation Synthesis of bis(thio-hydrazide amide) salts
BRPI0614826A2 (en) 2005-08-16 2011-04-19 Synta Pharmaceuticals Corp compositions, method for the preparation of lyophilisate of a composition and lyophilisate
EP2076254A2 (en) 2006-08-31 2009-07-08 Synta Pharmaceuticals Corporation Combination with bis(thiohydrazide amides) for treating cancer
US7645904B2 (en) 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2475478C2 (en) * 2006-08-21 2013-02-20 Синта Фармасьютиклз Корп. Compounds for treatment of proliferative disorders

Also Published As

Publication number Publication date
CH548990A (en) 1974-05-15
CH547787A (en) 1974-04-11
SU461095A1 (en) 1975-02-25
FR2097737A5 (en) 1972-03-03
DE2126304A1 (en) 1972-01-20
DE2126304C3 (en) 1979-11-15
HU164570B (en) 1974-03-28
DE2126304B2 (en) 1979-03-29
HU164569B (en) 1974-03-28

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