SU683749A1 - Method of quantitative determination of hemoglobin dissociation rate in blood - Google Patents

Method of quantitative determination of hemoglobin dissociation rate in blood

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Publication number
SU683749A1
SU683749A1 SU731978094A SU1978094A SU683749A1 SU 683749 A1 SU683749 A1 SU 683749A1 SU 731978094 A SU731978094 A SU 731978094A SU 1978094 A SU1978094 A SU 1978094A SU 683749 A1 SU683749 A1 SU 683749A1
Authority
SU
USSR - Soviet Union
Prior art keywords
blood
quantitative determination
hemoglobin
dissociation rate
hemoglobin dissociation
Prior art date
Application number
SU731978094A
Other languages
Russian (ru)
Inventor
Леонид Андреевич Тиунов
Александр Ильич Клиорин
Тамара Семеновна Колосова
Original Assignee
Л. А. Тиунов, А. И. Клиорнн и Т. С. Колосова
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Л. А. Тиунов, А. И. Клиорнн и Т. С. Колосова filed Critical Л. А. Тиунов, А. И. Клиорнн и Т. С. Колосова
Priority to SU731978094A priority Critical patent/SU683749A1/en
Application granted granted Critical
Publication of SU683749A1 publication Critical patent/SU683749A1/en

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Description

Изобретение относитс  к медицине, а именно к гематологии.The invention relates to medicine, namely to hematology.

Известен способ количественного определени  скорости распада гемоглобина в крови путем учета количества желчных  илментов, выдел емых в течение суток из организма 1.The known method for the quantitative determination of the rate of hemoglobin breakdown in the blood by taking into account the amount of biliary illaments released during the day from the body 1.

Однако известный способ длителен и трудоемок и не позвол ет быстро количественно определить скорость распада гемоглобина Е крови. Целью изобретени   вл етс  сокращение .времени определени .However, the known method is long and laborious and does not allow for a quick quantitative determination of the rate of blood hemoglobin E decay. The aim of the invention is to reduce the detection time.

Эта цель достигаетс  тем, что обследуемого выдержи5вают в состо нии поко  в течение 15-30 мин в помещении, не содерлсащем окиси углерода, отбирают пробуThis goal is achieved by the fact that the subject is kept at rest for 15-30 minutes in a room that does not contain carbon monoxide, and a sample is taken

выды.хаемого воздуха в течение 15-30 мин., измер ют в пробе количество окиси углерода и о гредел ют распад гемоглобина по формулеexhaled air for 15–30 min., the amount of carbon monoxide in the sample is measured and the decomposition of hemoglobin is calculated by the formula

Х /40-589,3,X / 40-589.3,

где X - количество гемоглобина в граммах , распавшегос  в пересчете на 1 {./ - эмпирически найденна  посто нна  дл  разных возрастных групп, представлена в таблице; а - количество окиси углерода в граммах, выдел ющейс  в пересчете на 1 ч; 589,3 - посто нна  ,величинаwhere X is the amount of hemoglobin in grams, decayed in terms of 1 {./ - the empirically found constant for different age groups is presented in the table; a is the amount of carbon monoxide in grams releasing per hour; 589.3 - constant value

MoiO (.lei)MoiO (.lei)

о:;ь;ше /оabout:; ь; she / o

Способ осуществл ют следуюниш образом .The method is carried out in the following manner.

Обследуемый в состо нии поко  находитс  в течение о мин s помещении, воздух которого свободен от окиси углерода. Затем у обследуемого отбираетс  пробаThe patient in a state of rest is in a room for about min s, the air of which is free of carbon monoxide. A sample is then taken from the patient.

выдыхаемого воздуха в емкость (например в мешок Дугласа). Дл  создани  Еоспроизводнмости условий врем  отбора выдыхаемого воздуха должно быть реглаиектировгНО в пределах 15-30 мин, например 15 мин.exhaled air into a container (for example into a Douglas bag). In order to create conditions, the expiration time for exhaled air should be regulated within 15-30 minutes, for example, 15 minutes.

В отобранной пробе выдыхаемого воздуха измер ют концентрацию окиси углерода. По концентрации окиси угл-ерода, с учетом объема пробы, продолжительности ее отбора и поиравочных коэффициентов, учитывающих долю окиси утлерода, образующейс  за счет распада гемоглобина, определ ют скорость распада гемогло-бина.The concentration of carbon monoxide is measured in an exhaled breath sample. The decomposition rate of hemoglobin is determined from the concentration of carbon monoxide oxide, taking into account the volume of the sample, the duration of its sampling, and the relative coefficients that take into account the proportion of the carbon dioxide produced by hemoglobin decomposition.

Предла1гаемый оиособ количе-ст веиного оп/ределени  скорости расиада (ката болизма ) гем&глобииа был аиробирован в клинических услови х. С его иомощью было обследовано более 30 детей в возрасте от 3 до 15 лет с различными сом.атическими заболевани ми . Дл  измерени  выдел ющейс  окиси глерода был применен газоанализатор УГ-2.The proposed method of quantitative determination of the speed of the rasiada (catalysis) heme & globia was performed in a clinical setting. With his help, more than 30 children aged from 3 to 15 years old with various som. Diseases were examined. A gas analyzer, UG-2, was used to measure the release of glerode oxide.

Нацример, у обследуемого скорость распада гемоглобина, определенна  предлагаем .ым способом, составила 90 .чгг/кг/сут ки, что согласуетс  с данными обследовани  другими способам и.The natrimer, in the subject, the rate of hemoglobin disintegration, determined by the proposed method, was 90. Kg / kg / day, which is consistent with the survey data from other methods and.

С иомощью предлагаемого способа можно .вы вить нарушение эритроиозза и скрытых кровотечений.With the help of the proposed method it is possible. You can establish a violation of erythroisis and latent bleeding.

Предлагаемый способ удобен в работе, прост в осущеспвлеиии, безвреден дл  обследуемого , не требует специального дорогосто шего оборудовани  и позвол ет оыстро определить скорость расиада гемоглобина в крови.The proposed method is easy to use, easy to implement, harmless to the subject, does not require special expensive equipment, and allows you to quickly determine the rate of hemoglobin in the blood.

Claims (1)

1. Коржуев П. А. Гемоглобин, М., «Наука , 1964 (прототип).1. Korzhuev P. A. Hemoglobin, M., “Science, 1964 (prototype).
SU731978094A 1973-12-14 1973-12-14 Method of quantitative determination of hemoglobin dissociation rate in blood SU683749A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU731978094A SU683749A1 (en) 1973-12-14 1973-12-14 Method of quantitative determination of hemoglobin dissociation rate in blood

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU731978094A SU683749A1 (en) 1973-12-14 1973-12-14 Method of quantitative determination of hemoglobin dissociation rate in blood

Publications (1)

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SU683749A1 true SU683749A1 (en) 1979-09-05

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SU731978094A SU683749A1 (en) 1973-12-14 1973-12-14 Method of quantitative determination of hemoglobin dissociation rate in blood

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103430028A (en) * 2010-09-16 2013-12-04 通用医疗公司 Red blood cell dynamics for diagnosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103430028A (en) * 2010-09-16 2013-12-04 通用医疗公司 Red blood cell dynamics for diagnosis

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