SU670300A1 - Method of diagnosis of affected state of newborn baby during labor - Google Patents
Method of diagnosis of affected state of newborn baby during laborInfo
- Publication number
- SU670300A1 SU670300A1 SU782578387A SU2578387A SU670300A1 SU 670300 A1 SU670300 A1 SU 670300A1 SU 782578387 A SU782578387 A SU 782578387A SU 2578387 A SU2578387 A SU 2578387A SU 670300 A1 SU670300 A1 SU 670300A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- newborn
- activity
- dehydrogenase
- cervix
- diagnosis
- Prior art date
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
1one
Изобретение относитс к области перинатальной медицины.This invention relates to the field of perinatal medicine.
Известен способ диагностики нарушени состо ни новорожденного во врем родов путем количественного определени ферментов в крови роженицы.A known method for diagnosing a disorder of the condition of a newborn during childbirth by quantifying enzymes in the blood of the woman.
Однако известный способ пе обеспечивает раннего вы влени нарушений состо ни новорожденного в перинатальный период .However, the known method does not provide for the early detection of violations of the state of a newborn in the perinatal period.
Целью изобретени вл етс раннее вы вление нарушений состо ни новорожденного в перинатальный период.The aim of the invention is the early detection of disorders of the newborn in the perinatal period.
Эта цель достигаетс тем, что у роженицы при раскрытии шейки матки на 1-3 см и повторно при раскрытии шейки матки на 6-10 см в эритроцитах крови определ ют активность глюкозо-6-фосфатдегидрогеназы (Г-6-ФД) и 6-фосфоглюконатдегидрогеназы (6-ФГД), а в сыворотке крови - активность изоцитратдегидрогеназы (ИЦД) и лактатдегидрогеназы (ЛДГ), определ ют отношение величин активности ИЦД/ЛДГ и Г-6-ФД/6-ФГД и по изменению этих величин диагносцируют нарушение состо ни новорожденного.This goal is achieved by the fact that when the cervix opens the cervix 1-3 cm and again, when the cervix opens 6-10 cm, the activity of glucose-6-phosphate dehydrogenase (G-6-PD) and 6-phosphogluconate dehydrogenase are determined in red blood cells (6-FGD), and in the serum - the activity of isocitrate dehydrogenase (ICD) and lactate dehydrogenase (LDH), the ratio of the values of the activity of ICD / LDH and G-6-PD / 6-FGD is determined and, by changing these values, a violation of the condition of the newborn is detected .
Способ осушествл ют следуюшим образом .The method is carried out as follows.
У роженицы при раскрытии шейки матки на см и повторно при раскрытии шейки матки на 6-10 см из локтевой вены берут 2 мл крови в пробирку с 0,5 мл 1,34%-кого раствора оксалата и без него. Затем центрифугируют кровь при 1000 об/мин в течение 5 мин, после чего отсасывают 1 мл эритроцнтарной взвеси и трижды промывают 30-кратным объемомWhen a woman in labor, when opening the cervix per cm and again when opening the cervix, 6-10 cm from the ulnar vein, take 2 ml of blood into a tube with 0.5 ml of a 1.34% solution of oxalate and without it. Then the blood is centrifuged at 1000 rpm for 5 minutes, after which 1 ml of erythrocyte suspension is sucked off and washed three times with a 30-fold volume.
раствора, содержащего 0,15М хлористого магни . Надосадочную жидкость сливают. Эритроцитарную взвесь довод т до 2 мл, и определ ют в ней количество эритроцитов в камере Гор ева. Степень чистоты отмывки от лейкоцитов провер ют путем подсчета их количества в мазках. Промывку считают достаточной, если в поле зрени встречаютс единичные лейкоциты.solution containing 0.15M magnesium chloride. The supernatant is drained. The erythrocyte suspension is adjusted to 2 ml, and the number of erythrocytes in the Gorev chamber is determined in it. The purity of leukocyte washing is checked by counting their number in smears. Washing is considered sufficient if single leukocytes are found in the visual field.
Определ ют в эритроцитах активностьErythrocyte activity is determined
глюкозо-6-фосфатдегидрогеназы (Г-6-ФД) и 6-фосфоглюконатдегидрогеназы (6-ФГД), а в сыворотке крови рожениц в начале и в конце I периода родов (при раскрытии шейки матки на 1-3 и 6-10 см соответственно ) снижение отношени ИЦД/ЛДГ и повышение величины Г-6-ФД/6-ФГД к концу I периода родов прогнозирует нарушение состо ни плода и в последствии состо ни новорожденного с оценкой по шкале Аргач 7 и ниже, а при новышении величины ИЦД/ЛДГ и снижении Г-6-ФД/6-ФГД к концу I периода родов предполагают рождение здорового ребенка с оценкой по шкале Аргач 8-10.glucose-6-phosphate dehydrogenase (G-6-PD) and 6-phosphogluconate dehydrogenase (6-PGD), and in the blood serum at the beginning and at the end of the first period of labor (when opening the cervix at 1-3 and 6-10 cm, respectively ) a decrease in the ratio of IDC / LDH and an increase in the G-6-PD / 6-PGD value by the end of the first period of labor predicts a violation of the fetus state and, as a consequence, the condition of the newborn with an Argach score of 7 or less, and with an increase in the ICD / LDH value and a decrease in G-6-FD / 6-FGD by the end of the first period of labor implies the birth of a healthy child with an Argach score of 8-10.
Предлагаемый способ обеспечивает раннее вы вление нарушений состо ни нлода и здоровь новорожденного, что позвол ет своевременно нровести коррегирующую терапию при родах и Б послеродовом периоде и тем самым снизить перинатальную смертность .The proposed method provides for early detection of violations of the state of nlod and the health of the newborn, which allows for timely correction of the therapy during childbirth and the postpartum B and thereby reducing perinatal mortality.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782578387A SU670300A1 (en) | 1978-01-30 | 1978-01-30 | Method of diagnosis of affected state of newborn baby during labor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782578387A SU670300A1 (en) | 1978-01-30 | 1978-01-30 | Method of diagnosis of affected state of newborn baby during labor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU670300A1 true SU670300A1 (en) | 1979-06-30 |
Family
ID=20748329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU782578387A SU670300A1 (en) | 1978-01-30 | 1978-01-30 | Method of diagnosis of affected state of newborn baby during labor |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU670300A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008054303A3 (en) * | 2006-10-13 | 2008-06-05 | Mathias Karlsson | Method of determining hypoxia in scalp blood during labour |
-
1978
- 1978-01-30 SU SU782578387A patent/SU670300A1/en active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008054303A3 (en) * | 2006-10-13 | 2008-06-05 | Mathias Karlsson | Method of determining hypoxia in scalp blood during labour |
| US8945824B2 (en) | 2006-10-13 | 2015-02-03 | Calmark Sweden Aktiebolag | Method of determining hypoxia |
| EP2089535A4 (en) * | 2006-10-13 | 2015-03-18 | Calmark Sweden Aktiebolag | Method of determining hypoxia in scalp blood during labour |
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