SU502879A1 - The method of obtaining - (carbethoxy) - monoalkylthioacetamide - Google Patents

The method of obtaining - (carbethoxy) - monoalkylthioacetamide

Info

Publication number
SU502879A1
SU502879A1 SU1835072A SU1835072A SU502879A1 SU 502879 A1 SU502879 A1 SU 502879A1 SU 1835072 A SU1835072 A SU 1835072A SU 1835072 A SU1835072 A SU 1835072A SU 502879 A1 SU502879 A1 SU 502879A1
Authority
SU
USSR - Soviet Union
Prior art keywords
carbethoxy
obtaining
monoalkylthioacetamide
monoalkylthioacetamides
ethyl
Prior art date
Application number
SU1835072A
Other languages
Russian (ru)
Inventor
Владимир Александрович Печенюк
Леонид Борисович Дашкевич
Петр Васильевич Кузнецов
Original Assignee
Ленинградский химико-фармацевтический институт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ленинградский химико-фармацевтический институт filed Critical Ленинградский химико-фармацевтический институт
Priority to SU1835072A priority Critical patent/SU502879A1/en
Application granted granted Critical
Publication of SU502879A1 publication Critical patent/SU502879A1/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

1one

Изобретение относитс  к способу получени  новых а- (карбэтокси) -N-моиоалкилтиоацетамидов .This invention relates to a process for the preparation of novel a- (carbethoxy) -N-moioalkylthioacetamides.

Согласно изобретению а-(карбэтокси)-этилдитиоацетат подвергают взаимодействию с первичным алифатическим амином при 80- 90°С.According to the invention, a- (carbethoxy) -ethyl dithioacetate is reacted with a primary aliphatic amine at 80-90 ° C.

Основанный на известной реакции тиоацилировани  аминов предложенный способ позвол ет получить новые а-(карбэтокси)-N-моноалкилтиоацетамиды , содержащие нар ду с N-моноалкиламидной сложноэфирную группировку и представл ющие интерес как иСхХодные соединени  дл  синтеза новых лекарственных веществ, например производных амидопирина , норсульфазола.Based on the well-known reaction of thioacylation of amines, the proposed method allows to obtain new a- (carbethoxy) -N-monoalkylthioacetamides containing, along with the N-monoalkylamide ester group, and are of interest as CXH compounds for the synthesis of new medicinal substances, for example, derivatives of amidopyrine, noresulfonate, noresulfonate and nosulfide derivatives,

Пример. К охлажденным до 5°С 9,60 гExample. To cooled to 5 ° C 9.60 g

(0,05 мол ) а-(карбэтокси)-этилдитиоацетата прибавл ют 4,30 мл (0,05 мол ) свежеперегпанного изопропиламина. Смесь нагревают с обратным холодильником в течение 4 ч при 80-85°С. Выделившийс  в результате реакции этилмеркаптан отгон ют на вод ной бане , остаток подвергают перегонке в вакууме и получают в виде бесцветной жидкости а- (карбэтокси) -N-изопропилтиоацетамид.(0.05 mol) a- (carbethoxy) ethyl dithioacetate add 4.30 ml (0.05 mol) of freshly recrystallized isopropylamine. The mixture is heated under reflux for 4 hours at 80-85 ° C. The ethyl mercaptan released in the reaction is distilled off in a water bath, the residue is subjected to distillation in vacuo and obtained as a colorless liquid a- (carbethoxy) -N-isopropylthio-acetamide.

10ten

Аналогично получены другие тиоацетамиды. Их физические свойства и элементарный состав приведены в таблице.Other thioacetamides have been prepared similarly. Their physical properties and elemental composition are given in the table.

Полученные а- (карбэтокси) -N-моноалкилтиоадетамиды представл ют собой прозрачные , слегка желтоватые масл нистые жидкости со своеобразным специфическим запахом. 502879The resulting a- (carbethoxy) -N-monoalkylthioadetamides are clear, slightly yellowish oily liquids with a peculiar specific odor. 502879

Claims (1)

Формула изобретени Invention Formula Способ получени  а-(карбэтокси)-К-.моноалкилтиоацетамидов , отличающийс  тем, что а-(карбэтокси)-этилдитиоацетат подвергают взаимодействию с первичным алифатическим амином при 80-90°С с последующим выделением целевого продукта известными приемами.The method of obtaining a- (carbethoxy) -K-monoalkylthioacetamides, characterized in that a- (carbethoxy) ethyl dithioacetate is reacted with a primary aliphatic amine at 80-90 ° C, followed by isolation of the target product by known techniques.
SU1835072A 1972-10-06 1972-10-06 The method of obtaining - (carbethoxy) - monoalkylthioacetamide SU502879A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU1835072A SU502879A1 (en) 1972-10-06 1972-10-06 The method of obtaining - (carbethoxy) - monoalkylthioacetamide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1835072A SU502879A1 (en) 1972-10-06 1972-10-06 The method of obtaining - (carbethoxy) - monoalkylthioacetamide

Publications (1)

Publication Number Publication Date
SU502879A1 true SU502879A1 (en) 1976-02-15

Family

ID=20528897

Family Applications (1)

Application Number Title Priority Date Filing Date
SU1835072A SU502879A1 (en) 1972-10-06 1972-10-06 The method of obtaining - (carbethoxy) - monoalkylthioacetamide

Country Status (1)

Country Link
SU (1) SU502879A1 (en)

Similar Documents

Publication Publication Date Title
US2807644A (en) Pantethine inhibitors
SU453836A3 (en) Method of producing 3-benzylpyridine derivatives or their salts
SU502879A1 (en) The method of obtaining - (carbethoxy) - monoalkylthioacetamide
SU860696A1 (en) Method of preparing n-substituted thiobutyramides or their salts
SU457687A1 (en) Method for producing methylene 2,2-biscyclopentanone
ES423985A1 (en) Procedure for the preparation of n, N-bis- (2- (3,4-dihydroxypenyl) -2-hydroxyethyl) -hexameethylendiamine and of its salts by addition of acid. (Machine-translation by Google Translate, not legally binding)
SU523082A1 (en) Method of producing oxyalkylamides α-acylglycine
US4376731A (en) 1-Aziridine carboxylic acid derivatives with immunostimulant activity
SU537068A1 (en) The method of obtaining esters of α-acyl-aryl-α-amino acids
SU452562A1 (en) The method of obtaining 2-strength-1,3-dioxanone-6
SU368275A1 (en) VSESRYU.ED ^^ PATENTV9 "TSHG1I ^^ '
SU696008A1 (en) Ortho -substituted n -aminobenzylanilines as epoxy resin solidifying agents
SU467904A1 (en) The method of obtaining -imidoyl-0,0-dialkyldithiophosphates
Evans et al. 403. Synthesis of potential antibacterial agents. Part III. Derivatives of some αα′-dialkylglutaric acids
SU375299A1 (en) METHOD OF OBTAINING O. O-DIALKIL-Y-ACETIMIDO-p-CYAN-
SU407890A1 (en) METHOD OF OBTAINING ETHERS OF CYNYACIC ACID
SU338100A1 (en) The method of obtaining 1-aryl-3-alkyl-5- (alkyl) (aryl) carbamoyloxyhydantoin
FR2361365A1 (en) PROCESS FOR PREPARING INTERMEDIATE COMPOUNDS FOR THE SYNTHESIS OF 1-OXACEPHALOSPORINS AND NEW PRODUCTS THUS OBTAINED
SU363697A1 (en)
SU458549A1 (en) The method of obtaining 2-diethylaminethoxyalkoxy-3,4-dihydropyranes
SU541838A1 (en) Purification method of 1.12-dodecamethylenediamine
US2384068A (en) Manufacture of aminoalkylidene succinic acid derivatives
SU323002A1 (en) The method of obtaining halogen-substituted phenyl esters of cytizinobutins
SU487072A1 (en) Method for preparing 5-hydroxynicotinic acid esters
SU469683A1 (en) Method for preparing oxyphenyl methacrylic esters containing ketone or aldehyde groups