SU1415725A1 - 4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole dihydrochloride enhancing physical resistance - Google Patents
4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole dihydrochloride enhancing physical resistanceInfo
- Publication number
- SU1415725A1 SU1415725A1 SU4181259/04A SU4181259A SU1415725A1 SU 1415725 A1 SU1415725 A1 SU 1415725A1 SU 4181259/04 A SU4181259/04 A SU 4181259/04A SU 4181259 A SU4181259 A SU 4181259A SU 1415725 A1 SU1415725 A1 SU 1415725A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- phenylimidazole
- methoxyphenyl
- morpholinoethylthio
- dihydrochloride
- physical resistance
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FIELD: organic chemistry, imidazole derivatives. SUBSTANCE: product: 4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole. Synthesis is carried out by reaction of 2-mercapto-4-(4'-methoxyphenyl)-5-phenylimidazole with 2-morpholinoethyl bromide hydrobromide followed by conversion of obtained base to hydrochloride by treatment with HCl. Yield is 92%, m. p. is 155 C, empirical formula is CHClNOS.. Synthesized compound provides the best resistance at run as compared with control after 24 hr to 188%, toxicity LD= 575 mg/kg. EFFECT: synthesis of new substances showing enhanced activity. 1 tbl
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4181259/04A SU1415725A1 (en) | 1986-11-17 | 1986-11-17 | 4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole dihydrochloride enhancing physical resistance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU4181259/04A SU1415725A1 (en) | 1986-11-17 | 1986-11-17 | 4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole dihydrochloride enhancing physical resistance |
Publications (1)
Publication Number | Publication Date |
---|---|
SU1415725A1 true SU1415725A1 (en) | 1996-10-10 |
Family
ID=60536087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU4181259/04A SU1415725A1 (en) | 1986-11-17 | 1986-11-17 | 4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole dihydrochloride enhancing physical resistance |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU1415725A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7223781B2 (en) | 2001-03-26 | 2007-05-29 | Beiersdorf Ag | 2-mercapto-4,5-diarylimidazole derivatives and the use thereof as cyclooxygenase inhibitors |
US7582660B2 (en) | 2002-08-20 | 2009-09-01 | C-A-I-R Biosciences Gmbh | 2-thio-substituted imidazole derivatives and their use in pharmaceutics |
-
1986
- 1986-11-17 SU SU4181259/04A patent/SU1415725A1/en active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7223781B2 (en) | 2001-03-26 | 2007-05-29 | Beiersdorf Ag | 2-mercapto-4,5-diarylimidazole derivatives and the use thereof as cyclooxygenase inhibitors |
US7582660B2 (en) | 2002-08-20 | 2009-09-01 | C-A-I-R Biosciences Gmbh | 2-thio-substituted imidazole derivatives and their use in pharmaceutics |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BG104853A (en) | Thienylazolylalcoxyethanamines, their preparation and their application as medicaments | |
HUT47844A (en) | Process for producing pharmaceuticals comprising quinoline- or naphthyridinecarboxylic acid and tetracyclin derivatives as active ingredient | |
US4046908A (en) | Benzimidazole derivatives, compositions thereof and method of use as anthelmintics | |
SU1415725A1 (en) | 4-(4'-methoxyphenyl)-2-morpholinoethylthio-5-phenylimidazole dihydrochloride enhancing physical resistance | |
GR3015475T3 (en) | Sulfonylamino substituted bicyclyl hydroxamic acid derivatives. | |
US3734925A (en) | N-amino-3,4-dimethyl-6-isobutyl-phthalimides | |
US4389406A (en) | Meta-pyrazolylaminotetramisole analogs and their use in pharmaceutical compositions | |
GB1059174A (en) | Diazacycloalkane derivatives | |
EP0468825B1 (en) | Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same | |
USRE30990E (en) | Benzimidazole derivatives, compositions thereof and method of use as anthelmintics | |
US4042624A (en) | Antidepressant 2-[(substituted-1-naphthylmethyl)amino]-1-phenylpropanols | |
DE3777274D1 (en) | SYNTHESIS OF AZETIDINONES. | |
SU1631952A1 (en) | 3-(3-hydroxyaminopropyl)-4-hydroxybutyrate sodium hemisuccinate showing antinecrotic activity | |
SU1552605A1 (en) | 3-(2-dimethylaminoethylthio)-8-methoxy-1,2, 4-triazino-[5,6-b]- indole dihydrochloride enhancing resistance to hyperthermia | |
US4906781A (en) | Method for the preparation of 4'-(substituted)-amino-2-(substituted) amino-3',5'-dichloroacetophenone and salts thereof | |
US3528971A (en) | Cycloalkyl nitrofuryl nitrones | |
SU1640984A1 (en) | 1-amino-8,9-dihydro-5-morpholino-7,7,8-trimethyl-2-ethoxycarb- onyl-6h-thieno-[2,3-c][2, 7]-naphthiridine or its dihydrochloride showing mutagenic activity | |
SU1663928A1 (en) | 3-benzylamino-4-hydroxy-n-benzylbutaneamide hemiglutarate showing local anesthetizing activity | |
SU1623156A1 (en) | 3-(2-diethylaminoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide hydrochloride accelerating recovery process after physical loading | |
SU1732656A1 (en) | 2-(4-hydroxy-3-methoxy) styrylchromone having antihypoxic, hypertensive and antiallergic activities | |
SU1704415A1 (en) | 1-(2-ethoxyethyl)-4-ethynyl-4-benzoylhydroxypiperidine hydrochloride showing local anesthetic activity | |
RU95106120A (en) | 2-mercaptobenzimidazole derivatives showing antiischemic and antiarrhythmic activity | |
SU1674533A1 (en) | 3-(2-dimethylaminoethylthio)-1,2,4-triazino-[5,6-b]-indolyl-5- acetamide protecting against acute toxic lung edema | |
Tsoi et al. | Syntheses of some substituted sym-triazines | |
SU1596719A1 (en) | 3-(morpholinocarbonylmethylthio)-1,2,4-triazino-[5,6-b]-indole enhancing resistance to hypercapnic hypoxia |