SU1170348A1 - Method of determining individual senstivity of organism to introduction of pertussis vaccine - Google Patents
Method of determining individual senstivity of organism to introduction of pertussis vaccine Download PDFInfo
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- SU1170348A1 SU1170348A1 SU802988469A SU2988469A SU1170348A1 SU 1170348 A1 SU1170348 A1 SU 1170348A1 SU 802988469 A SU802988469 A SU 802988469A SU 2988469 A SU2988469 A SU 2988469A SU 1170348 A1 SU1170348 A1 SU 1170348A1
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- insulin
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- pertussis vaccine
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Abstract
СПОСОБ ОПРЕДЕЛЕНИЯ ИНДИВИДУАЛЬНОЙ ЧУВСТВИТЕЛЬНОСТИ ОРГАНИЗМА НА ВВЕДЕНИЕ КОКЛЮШНОЙ ВАКЦИНЫ путем измерени уровн гликемии после введени испытуемой вакцины, отличающийс тем, что, с целью повьшени чувствительности способа, животному дополнительно ввод т инсулин, измер ют зфовень гликемии после введени инсулина и по снижению показател , по cpaBrfeнию с контролем, определ ют индивидуальную чувствительность.. (Л СMETHOD FOR DETERMINING THE INDIVIDUAL SENSITIVITY OF THE ORGANISM FOR ADMINISTRATION OF THE POULTRY VACCINE by measuring the level of glycemia after administering a test vaccine, characterized in that, in order to increase the sensitivity of the method, the animal is additionally injected with insulin, measured by insulin, after an insulin is applied, after an insulin is applied, the animals are additionally insulin administered, the dosage of glycemia is measured by inspectors after an insulin is applied, an insulin is administered to the animal, insulin is absorbed after insulin treatment, and insulin is applied to the animal after the introduction of the test vaccine. control, determine the individual sensitivity .. (ls
Description
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Изобретение относитс к медицин в частности к микробиологии, и может найти применение при измерении индивидуальной биологической реакции биологического объекта при введении ассоциированных вакцин, содержащих коклюшный компонент.The invention relates to medicine, in particular, to microbiology, and may find application in measuring the individual biological response of a biological object when administering associated vaccines containing the pertussis component.
Способ осуществл ют следующим образом.The method is carried out as follows.
Осуществл ют введение коклюшной вакцины с последующей инъекцие инсулина в дозе 0,05-0,3 ед./кг и из;мер ют уровень гипогликемии.The pertussis vaccine is administered, followed by injection of insulin at a dose of 0.05-0.3 U / kg and from, and the level of hypoglycemia is measured.
исследование (инъекцию инсулина) осуществл ют спуст 520 дней после вакцинации, и изметрение уровн гипогликемии - спуст 20-80 мин после инъекции инсулина. the study (insulin injection) was performed 520 days after vaccination, and the hypoglycemia level was measured 20–80 minutes after insulin injection.
На фиг. 1 показано изменение концентрации глюкозы в крови мьш1ей при введении разных доз инсулина; на.фиг. 2 - зависимость суммарной « и пиковой S величины гипогликемии от дозы инсулина.FIG. 1 shows the change in the concentration of glucose in the blood of a child with the introduction of different doses of insulin; on. 2 - the dependence of the total and peak S values of hypoglycemia on insulin dose.
Пример 1. Ассоциированную вакцину АКДС-С-5 и С-3 серий ввод раздельным группам беспородныхExample 1. Associated vaccine AKDS-C-5 and C-3 of the series entering separate groups of purebred
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мьш1ей (при п 6) в дозах: О или 2 или 4 или В (млрд. микр. бел/мьш1ь) .1 (at 6) in doses of O or 2 or 4 or B (billion micron. bel / msh1).
Контрольна группа получает 0,5 мл физиологического раствора. Коклюшную вакцину ввод т внутрибрюшно .The control group receives 0.5 ml of saline. Pertussis vaccine is administered intraperitoneally.
Спуст 7 дней животных взвешивают и ввод т им подкожно инсулин в дозе 0,1 ед./кг. Спуст 40 минAfter 7 days, the animals are weighed and injected subcutaneously with insulin at a dose of 0.1 units / kg. After 40 min
мышей забивают и измер ют у них концентрацию глюкозы в крови глюкозооксидозным способом. Уровень гликемии по сравнению с контролем служит показателем реакции организма на введение коклюшной вакцины.The mice are sacrificed and their glucose concentration in the blood is measured by the glucose oxidase method. Glycemia compared with control is an indicator of the body's response to the introduction of pertussis vaccine.
Результаты исследовани реакции мьш1ей на введение препаратов , содержащих коклюшный компонент АКДС-С-5 и АКДС-С-ЗJприведены в табл. 1.The results of the study of the reaction of patients to the administration of drugs containing the pertussis component DTP-C-5 and DTP-C-3J are given in Table. one.
Результаты исследовани уровн гликемии в крови мьш1ей после введени разньк доз инсулина (в единицах , нормированных относительно контрол , изменение концентрации }глюкозы выполнено глюкозооксидазным способом) приведены в табл. 2.The results of the study of the glycemia level in the blood of the muscles after the injection of insulin doses (in units normalized to the control, the change in glucose concentration} performed by the glucose oxidase method) are given in Table. 2
Таблица 1Table 1
Таблица 2table 2
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU802988469A SU1170348A1 (en) | 1980-09-22 | 1980-09-22 | Method of determining individual senstivity of organism to introduction of pertussis vaccine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU802988469A SU1170348A1 (en) | 1980-09-22 | 1980-09-22 | Method of determining individual senstivity of organism to introduction of pertussis vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1170348A1 true SU1170348A1 (en) | 1985-07-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU802988469A SU1170348A1 (en) | 1980-09-22 | 1980-09-22 | Method of determining individual senstivity of organism to introduction of pertussis vaccine |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1170348A1 (en) |
-
1980
- 1980-09-22 SU SU802988469A patent/SU1170348A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Захарова Н.С., Мошиашвили И.Я., Джексембаев О.Ш. Вли ние коклюшной вакцины на углеводный обмен мышей и их чувствительность к серотонину и гистамину. ЖЮЙ, 1968, т. 8, е. 16. * |
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