SK85997A3 - Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents - Google Patents

Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents Download PDF

Info

Publication number: SK85997A3
Authority: SK; Slovakia
Prior art keywords: paclitaxel; cyclosporin; agent; oral; group
Prior art date: 1995-10-26

Application number

SK859-97A

Other languages

English (en)

Slovak (sk)

Inventor

Samuel Broder

Kenneth L Duchin

Sami Selim

Original Assignee

Baker Norton Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-26

Filing date

1996-10-24

Publication date

1998-06-03

1996-02-29 Priority claimed from US08/608,776 external-priority patent/US5968972A/en

1996-10-24 Application filed by Baker Norton Pharma filed Critical Baker Norton Pharma

1998-06-03 Publication of SK85997A3 publication Critical patent/SK85997A3/sk

Links

230000001965 increasing effect Effects 0.000 title claims abstract description 30
238000000034 method Methods 0.000 title abstract description 43
239000000203 mixture Substances 0.000 title description 19
239000008177 pharmaceutical agent Substances 0.000 title description 3
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims abstract description 284
229960001592 paclitaxel Drugs 0.000 claims abstract description 278
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239000003795 chemical substances by application Substances 0.000 claims abstract description 176
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PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims abstract description 141
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ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims abstract description 29
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Classifications

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Virology (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

SK859-97A 1995-10-26 1996-10-24 Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents SK85997A3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US707195P	1995-10-26	1995-10-26
US08/608,776 US5968972A (en)	1995-10-26	1996-02-29	Method for increasing the oral bioactivity of pharmaceutical agents
US08/733,142 US6245805B1 (en)	1995-10-26	1996-10-16	Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
PCT/IB1996/001485 WO1997015269A2 (en)	1995-10-26	1996-10-24	Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents

Publications (1)

Publication Number	Publication Date
SK85997A3 true SK85997A3 (en)	1998-06-03

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ID=27358262

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Application Number	Title	Priority Date	Filing Date
SK859-97A SK85997A3 (en)	1995-10-26	1996-10-24	Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents

Country Status (22)

Country	Link
US (6)	US6245805B1 (de)
EP (1)	EP0794794B1 (de)
JP (1)	JP3361102B2 (de)
CN (2)	CN1119146C (de)
AT (1)	ATE311903T1 (de)
AU (1)	AU698142B2 (de)
BR (1)	BR9607066A (de)
CA (1)	CA2205534A1 (de)
CZ (1)	CZ202897A3 (de)
DE (2)	DE69636531T2 (de)
DK (1)	DK0794794T3 (de)
ES (1)	ES2109899T3 (de)
HK (1)	HK1001960A1 (de)
HU (1)	HUP9900457A3 (de)
IL (1)	IL121160A0 (de)
MX (1)	MX9704629A (de)
NO (1)	NO321091B1 (de)
NZ (1)	NZ324801A (de)
PL (2)	PL192544B1 (de)
RU (1)	RU2217135C2 (de)
SK (1)	SK85997A3 (de)
WO (1)	WO1997015269A2 (de)

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1996
- 1996-10-16 US US08/733,142 patent/US6245805B1/en not_active Expired - Fee Related
- 1996-10-24 AU AU12056/97A patent/AU698142B2/en not_active Ceased
- 1996-10-24 DK DK96943268T patent/DK0794794T3/da active
- 1996-10-24 AT AT96943268T patent/ATE311903T1/de not_active IP Right Cessation
- 1996-10-24 BR BR9607066-8A patent/BR9607066A/pt not_active Application Discontinuation
- 1996-10-24 MX MX9704629A patent/MX9704629A/es not_active IP Right Cessation
- 1996-10-24 HU HU9900457A patent/HUP9900457A3/hu unknown
- 1996-10-24 CA CA002205534A patent/CA2205534A1/en not_active Abandoned
- 1996-10-24 CN CN96191685A patent/CN1119146C/zh not_active Expired - Fee Related
- 1996-10-24 CZ CZ972028A patent/CZ202897A3/cs unknown
- 1996-10-24 PL PL368566A patent/PL192544B1/pl unknown
- 1996-10-24 NZ NZ324801A patent/NZ324801A/xx unknown
- 1996-10-24 WO PCT/IB1996/001485 patent/WO1997015269A2/en active IP Right Grant
- 1996-10-24 RU RU97112888/14A patent/RU2217135C2/ru not_active IP Right Cessation
- 1996-10-24 JP JP51644997A patent/JP3361102B2/ja not_active Expired - Fee Related
- 1996-10-24 DE DE69636531T patent/DE69636531T2/de not_active Expired - Fee Related
- 1996-10-24 SK SK859-97A patent/SK85997A3/sk unknown
- 1996-10-24 PL PL96321791A patent/PL188281B1/pl not_active IP Right Cessation
- 1996-10-24 IL IL12116096A patent/IL121160A0/xx unknown
- 1996-10-24 EP EP96943268A patent/EP0794794B1/de not_active Expired - Lifetime
- 1996-10-24 CN CNB031458033A patent/CN100335123C/zh not_active Expired - Fee Related
- 1996-10-24 DE DE0794794T patent/DE794794T1/de active Pending
- 1996-10-24 ES ES96943268T patent/ES2109899T3/es not_active Expired - Lifetime
1997
- 1997-06-25 NO NO19972968A patent/NO321091B1/no unknown
1998
- 1998-02-11 HK HK98101042A patent/HK1001960A1/xx not_active IP Right Cessation
2001
- 2001-04-10 US US09/829,846 patent/US6610735B2/en not_active Expired - Fee Related
2002
- 2002-09-12 US US10/242,050 patent/US6818615B2/en not_active Expired - Fee Related
2004
- 2004-03-15 US US10/800,990 patent/US7041640B2/en not_active Expired - Fee Related
2005
- 2005-04-13 US US11/105,081 patent/US20050238634A1/en not_active Abandoned
2006
- 2006-08-14 US US11/503,607 patent/US20070060635A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL188281B1 (pl)	2005-01-31
US20040176439A1 (en)	2004-09-09
NO972968D0 (no)	1997-06-25
US20070060635A1 (en)	2007-03-15
US6610735B2 (en)	2003-08-26
US20030069301A1 (en)	2003-04-10
DE69636531D1 (de)	2006-10-19
AU698142B2 (en)	1998-10-22
JP3361102B2 (ja)	2003-01-07
EP0794794A1 (de)	1997-09-17
CN1119146C (zh)	2003-08-27
DK0794794T3 (da)	2006-04-18
BR9607066A (pt)	2002-12-10
WO1997015269A3 (en)	1997-07-31
PL321791A1 (en)	1997-12-22
HUP9900457A2 (hu)	1999-06-28
RU2217135C2 (ru)	2003-11-27
DE794794T1 (de)	1998-03-12
NO972968L (no)	1997-07-23
DE69636531T2 (de)	2006-12-07
ES2109899T3 (es)	2006-05-01
AU1205697A (en)	1997-05-15
CZ202897A3 (cs)	1998-03-18
EP0794794A4 (de)	2000-03-01
MX9704629A (es)	1997-09-30
JPH10509741A (ja)	1998-09-22
NO321091B1 (no)	2006-03-13
US20020058616A1 (en)	2002-05-16
US20050238634A1 (en)	2005-10-27
CN1173817A (zh)	1998-02-18
HUP9900457A3 (en)	2001-04-28
PL192544B1 (pl)	2006-11-30
NZ324801A (en)	1999-05-28
ATE311903T1 (de)	2005-12-15
CN1490048A (zh)	2004-04-21
WO1997015269A2 (en)	1997-05-01
ES2109899T1 (es)	1998-02-01
IL121160A0 (en)	1997-11-20
CN100335123C (zh)	2007-09-05
CA2205534A1 (en)	1997-05-01
US6818615B2 (en)	2004-11-16
EP0794794B1 (de)	2005-12-07
US6245805B1 (en)	2001-06-12
HK1001960A1 (en)	1998-07-24
US7041640B2 (en)	2006-05-09

Publication	Publication Date	Title
SK85997A3 (en)	1998-06-03	Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
RU2296561C2 (ru)	2007-04-10	Способ, лекарственная форма и наборы для повышения пероральной биологической доступности фармацевтических агентов
US6730698B2 (en)	2004-05-04	Method and compositions for administering taxanes orally to human patients
SK18782001A3 (sk)	2002-09-10	Orálne farmaceutické zmesi obsahujúce taxány a spôsoby liečenia s ich využitím
EP0994706B1 (de)	2005-11-02	Zusammensetzungen zur oralen verabreichung von taxanen und deren verwendung
CZ20021484A3 (cs)	2003-12-17	Farmaceutický prostředek obsahující taxan pro orální podávání lidem
EP1634607A2 (de)	2006-03-15	Verfahren, Zusammensetzungen und Kits zur Erhöhung der oralen Bioverfügbarkeit von Pharmazeutika
KR100563824B1 (ko)	2006-11-10	제약학적약물의경구생체내이용효율을증가시키기위한조성물및키트
AU784159B2 (en)	2006-02-16	Method and compositions for administering taxanes orally to human patients
MXPA99010850A (en)	2001-05-17	Method and compositions for administering taxanes orally to human patients