SK286332B6 - Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use - Google Patents

Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use Download PDF

Info

Publication number
SK286332B6
SK286332B6 SK50041-2007A SK500412007A SK286332B6 SK 286332 B6 SK286332 B6 SK 286332B6 SK 500412007 A SK500412007 A SK 500412007A SK 286332 B6 SK286332 B6 SK 286332B6
Authority
SK
Slovakia
Prior art keywords
dihydro
chlorophenyl
solution
pyrrolizin
mixture
Prior art date
Application number
SK50041-2007A
Other languages
English (en)
Slovak (sk)
Inventor
Stefan Laufer
Karola Tollmann
Hans-Gunter Striegel
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Publication of SK286332B6 publication Critical patent/SK286332B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK50041-2007A 1999-11-23 1999-11-23 Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use SK286332B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1999/009057 WO2001005792A1 (de) 1999-11-23 1999-11-23 Antiinflammatorische oxo- und hydroxyderivate von pyrrolizinen und deren anwendung in der pharmazie

Publications (1)

Publication Number Publication Date
SK286332B6 true SK286332B6 (en) 2008-07-07

Family

ID=8167504

Family Applications (2)

Application Number Title Priority Date Filing Date
SK676-2002A SK286082B6 (sk) 1999-11-23 1999-11-23 Protizápalové oxo- a hydroxyderiváty pyrolizínov a ich použitie vo farmácii
SK50041-2007A SK286332B6 (en) 1999-11-23 1999-11-23 Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK676-2002A SK286082B6 (sk) 1999-11-23 1999-11-23 Protizápalové oxo- a hydroxyderiváty pyrolizínov a ich použitie vo farmácii

Country Status (16)

Country Link
US (1) US6878738B1 (ja)
EP (2) EP1232158B1 (ja)
JP (1) JP2003505390A (ja)
KR (1) KR100632331B1 (ja)
AT (2) ATE260280T1 (ja)
AU (1) AU768525B2 (ja)
CA (1) CA2391871C (ja)
DE (1) DE59908677D1 (ja)
DK (1) DK1232158T3 (ja)
ES (1) ES2291577T3 (ja)
HK (1) HK1047095B (ja)
HU (1) HUP0204336A3 (ja)
MX (1) MXPA02005080A (ja)
PL (1) PL199752B1 (ja)
SK (2) SK286082B6 (ja)
WO (1) WO2001005792A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10001166A1 (de) 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
DE10004157A1 (de) 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
BR0212244A (pt) 2001-08-30 2004-10-05 Merckle Gmbh Uso de um ou mais do que um composto e seus isÈmeros ópticos, derivados e sais fisiologicamente aceitáveis, composição farmacêutica, e, método de tratamento ou de prevenção da degeneração ou da destruição de cartilagem articular e/ou de osso subcondral em uma ou mais articulações de um mamìfero
CZ2007752A3 (cs) * 2007-10-30 2009-05-13 Zentiva, A. S. Nový zpusob výroby 2-(6-(4-chlorfenyl)-2,2-dimethyl-7-fenyl-2,3-dihydro-1H-pyrrolizin-5-yl)octové kyseliny (licofelonu)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU429651B2 (en) 1968-08-08 1972-11-01 Commonwealth Scientific And Industrial Research Organization Antiviral 6, 7 dihydro 5h pyrrolizines and related compounds
FR2539417A1 (fr) 1983-01-13 1984-07-20 Rhone Poulenc Sante Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent
FR2557111B1 (fr) 1983-12-21 1986-04-11 Rhone Poulenc Sante Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
US5260451A (en) * 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE4419246A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419315A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419247A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie
JPH08127583A (ja) * 1994-10-31 1996-05-21 Kitasato Inst:The Ｆｏ−２０４７物質およびその製造法
DE19845446A1 (de) * 1998-10-02 2000-04-06 Merckle Gmbh Antiinflammatorische Oxo- und Hydroxyderivate von Pyrrolizinen und deren Verwendung in der Pharmazie

Also Published As

Publication number Publication date
WO2001005792A1 (de) 2001-01-25
SK6762002A3 (en) 2003-04-01
EP1398315B1 (de) 2007-08-08
HUP0204336A2 (hu) 2003-04-28
DE59908677D1 (de) 2004-04-01
EP1398315A1 (de) 2004-03-17
DK1232158T3 (da) 2004-06-14
SK286082B6 (sk) 2008-03-05
PL357468A1 (en) 2004-07-26
AU768525B2 (en) 2003-12-18
WO2001005792A9 (de) 2002-08-29
EP1232158A1 (de) 2002-08-21
US6878738B1 (en) 2005-04-12
CA2391871C (en) 2009-01-27
ES2291577T3 (es) 2008-03-01
HK1047095A1 (en) 2003-02-07
JP2003505390A (ja) 2003-02-12
HUP0204336A3 (en) 2006-01-30
KR20020071868A (ko) 2002-09-13
PL199752B1 (pl) 2008-10-31
MXPA02005080A (es) 2002-12-09
KR100632331B1 (ko) 2006-10-11
CA2391871A1 (en) 2001-01-25
EP1232158B1 (de) 2004-02-25
HK1047095B (zh) 2004-10-15
ATE260280T1 (de) 2004-03-15
AU1776400A (en) 2001-02-05
ATE369369T1 (de) 2007-08-15

Similar Documents

Publication Publication Date Title
RU2718060C2 (ru) Замещенные хроманы
US20210292340A1 (en) Cell necrosis inhibitor, preparation method therefor and use thereof
KR20130126912A (ko) 약물 유도체
EP0540604A1 (en) Substituted bicyclic bis-aryl compounds exhibiting selective leukotriene b 4? antagonist activity, their preparation and use in pharmaceutical compositions
JP2023027102A (ja) オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物
CA2578955A1 (en) Isoindolin-1-one derivatives
EP4056571A1 (en) Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof
US4783472A (en) 1H,3H-pyrrol[1,2-c]thiazole derivatives and pharmaceutical compositions containing them
US20230157999A1 (en) Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (aatd)
US6822120B2 (en) Sulfone liver X-receptor modulators
US6867211B2 (en) 4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy
SK286332B6 (en) Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use
US20220267346A1 (en) Thienopyrimidine derivatives having stereo configurations and use thereof in medicine
US6936632B2 (en) Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof
WO2005123073A1 (en) Marine compounds with calcium channel blocking properties for the treatment of cognitive or neurodegenerative diseases
US6265402B1 (en) Use of 2-phenylmorpholin-5-one derivatives
KR100331515B1 (ko) 치환된피롤
CZ20021783A3 (cs) Protizánětlivé oxo a hydroxyderiváty pyrrolizinů » a jejich použití ve farmacii
CN113874357A (zh) 金属β内酰胺酶抑制剂

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20091123