SK285990B6 - Kombinácia nesedatívnych antihistaminík so substanciami, ktoré ovplyvňujú pôsobenie leukotriénu, naošetrovanie rinitídy/konjunktivitídy - Google Patents

Kombinácia nesedatívnych antihistaminík so substanciami, ktoré ovplyvňujú pôsobenie leukotriénu, naošetrovanie rinitídy/konjunktivitídy Download PDF

Info

Publication number: SK285990B6
Authority: SK; Slovakia
Prior art keywords: antagonist; leukotriene; pharmaceutical composition; allergic; azelastine
Prior art date: 2000-02-17

Application number

SK1175-2002A

Other languages

English (en)

Slovak (sk)

Other versions

SK11752002A3 (sk

Inventor

Hildegard Kuss

J�Rgen Engel

Istvan Szelenyi

Original Assignee

Viatris Gmbh & Co. Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-17

Filing date

2001-02-05

Publication date

2008-01-07

2001-02-05 Application filed by Viatris Gmbh & Co. Kg filed Critical Viatris Gmbh & Co. Kg

2002-11-06 Publication of SK11752002A3 publication Critical patent/SK11752002A3/sk

2008-01-07 Publication of SK285990B6 publication Critical patent/SK285990B6/sk

Links

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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Pulmonology (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Ophthalmology & Optometry (AREA)
Inorganic Chemistry (AREA)
Dispersion Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

SK1175-2002A 2000-02-17 2001-02-05 Kombinácia nesedatívnych antihistaminík so substanciami, ktoré ovplyvňujú pôsobenie leukotriénu, naošetrovanie rinitídy/konjunktivitídy SK285990B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10007203A DE10007203A1 (de)	2000-02-17	2000-02-17	Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
PCT/EP2001/001190 WO2001060407A2 (de)	2000-02-17	2001-02-05	Neue kombination nichtsedierender antihistaminika mit substanzen, die die leukotrienwirkung beeinflussen, zur behandlung der rhinitis/konjunktivitis

Publications (2)

Publication Number	Publication Date
SK11752002A3 SK11752002A3 (sk)	2002-11-06
SK285990B6 true SK285990B6 (sk)	2008-01-07

Family

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Application Number	Title	Priority Date	Filing Date
SK1175-2002A SK285990B6 (sk)	2000-02-17	2001-02-05	Kombinácia nesedatívnych antihistaminík so substanciami, ktoré ovplyvňujú pôsobenie leukotriénu, naošetrovanie rinitídy/konjunktivitídy

Country Status (27)

Country	Link
US (1)	US6436924B2 (xx)
EP (1)	EP1265615B1 (xx)
JP (1)	JP5529362B2 (xx)
KR (1)	KR100764329B1 (xx)
CN (1)	CN1241569C (xx)
AR (1)	AR027528A1 (xx)
AT (1)	ATE287266T1 (xx)
AU (1)	AU781177B2 (xx)
BR (1)	BR0108445A (xx)
CZ (1)	CZ296395B6 (xx)
DE (2)	DE10007203A1 (xx)
DK (1)	DK1265615T3 (xx)
ES (1)	ES2236189T3 (xx)
HK (1)	HK1053792A1 (xx)
HU (1)	HU228927B1 (xx)
IL (2)	IL151106A0 (xx)
MX (1)	MXPA02008064A (xx)
NO (1)	NO328153B1 (xx)
NZ (1)	NZ520470A (xx)
PL (1)	PL198357B1 (xx)
PT (1)	PT1265615E (xx)
RU (1)	RU2292208C2 (xx)
SK (1)	SK285990B6 (xx)
TW (1)	TWI296525B (xx)
UA (1)	UA72587C2 (xx)
WO (1)	WO2001060407A2 (xx)
ZA (1)	ZA200206575B (xx)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2373186A (en) *	2001-02-23	2002-09-18	Astrazeneca Ab	Pharmaceutical combinations of a CCR3 antagonist and a compound which is usefulreatment of asthma, allergic disease or inflammation
FR2833493B1 (fr) *	2001-12-18	2005-09-23	Ioltechnologie Production	Forme galenique solide et soluble pour l'administration occulaire de principes actifs et procede de fabrication d'un insert ophtalmique solide et soluble
WO2003101434A2 (en) *	2001-12-21	2003-12-11	Sampad Bhattacharya	Intranasal pharmaceutical compositions comprising an antihistamine and a leukotriene inhibitor
GB2389530B (en)	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
US20080293750A1 (en) *	2002-10-17	2008-11-27	Anna Helgadottir	Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20060019269A1 (en) *	2002-10-17	2006-01-26	Decode Genetics, Inc.	Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US7851486B2 (en)	2002-10-17	2010-12-14	Decode Genetics Ehf.	Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
WO2005027886A2 (en) *	2003-09-17	2005-03-31	Decode Genetics Ehf.	Methods of preventing or treating recurrence of myocardial infarction
AU2003301305A1 (en) *	2002-10-17	2004-05-04	Decode Genetics Ehf.	Susceptibility gene for myocardial infarction; methods of treatment
US7507531B2 (en)	2002-10-17	2009-03-24	Decode Genetics Chf.	Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
WO2004069338A1 (en) *	2003-01-31	2004-08-19	Schering Corporation	Use of combinations of h1 and h3 histamine receptor antagonists for the preparation of a medicament for the treatment of allergic skin and allergic ocular conditions
US20040235807A1 (en) *	2003-05-21	2004-11-25	Weinrich Karl P.	Formulations including a topical decongestant and a topical corticosteroid suitable for nasal administration and method for treating obstructive sleep apnea
WO2005030331A1 (en) *	2003-09-26	2005-04-07	Fairfield Clinical Trials, Llc	Combination antihistamine medication
US20060263350A1 (en) *	2003-09-26	2006-11-23	Fairfield Clinical Trials Llc	Combination antihistamine medication
US20100216863A1 (en) *	2004-01-30	2010-08-26	Decode Genetics Ehf.	Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
SI1713471T1 (sl) *	2004-02-06	2012-07-31	Meda Pharma Gmbh & Co Kg	Kombinacija antiholinergikov in inhibitorjev fosfodiesteraze tipa za zdravljenje respiratornih bolezni
ES2413011T3 (es) *	2004-02-06	2013-07-15	Meda Pharma Gmbh & Co. Kg	Combinación de anticolinérgicos y glucocorticoides para el tratamiento a largo plazo de asma y EPOC
PE20060484A1 (es) *	2004-07-14	2006-07-06	Ucb Farchim Sa	Preparaciones farmaceuticas liquidas que comprenden un compuesto de benzhidril piperizina
US20070020330A1 (en)	2004-11-24	2007-01-25	Medpointe Healthcare Inc.	Compositions comprising azelastine and methods of use thereof
DK2377557T3 (en)	2004-11-24	2017-02-06	Meda Pharmaceuticals Inc	Compositions comprising azelastine and methods for its use
US8758816B2 (en)	2004-11-24	2014-06-24	Meda Pharmaceuticals Inc.	Compositions comprising azelastine and methods of use thereof
RU2420285C2 (ru) *	2005-03-16	2011-06-10	Меда Фарма Гмбх Унд Ко.Кг	Комбинация r,r-гликопирролата и монтелукаста для лечения респираторных заболеваний и фармацевтическая композиция на ее основе
US7405302B2 (en) *	2005-10-11	2008-07-29	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (FLAP) inhibitors
DE602006008665D1 (de) *	2005-12-21	2009-10-01	Meda Pharma Gmbh & Co Kg	Kombination von r,r-glycopyrrolat, rolipram und budesonid zur behandlung von entzündungskrankheiten
WO2007126865A2 (en) *	2006-03-30	2007-11-08	Patrin Pharma	Leukotriene antagonists via nasal drug delivery
EP2086531A4 (en)	2006-11-30	2009-09-30	Amira Pharmaceuticals Inc	COMPOSITIONS AND TREATMENTS COMPRISING 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS AND NITRIC OXIDE MODULATORS
WO2009067317A2 (en) *	2007-11-19	2009-05-28	Bausch & Lomb Incorporated	Use of levocabastine for modulating generation of pro- inflammatory cytokines
US20100240624A1 (en) *	2009-03-17	2010-09-23	Aciex Therapeutics, Inc.	Ophthalmic Formulations of Ketotifen and Methods of Use
EP2408453B1 (en) *	2009-03-17	2022-01-05	Nicox Ophthalmics, Inc.	Ophthalmic formulations of cetirizine and methods of use
US8569273B2 (en)	2009-03-17	2013-10-29	Aciex Therapeutics, Inc.	Ophthalmic formulations of cetirizine and methods of use
CN104042617A (zh)	2009-04-29	2014-09-17	阿马里纳药物爱尔兰有限公司	含有epa和心血管剂的药物组合物以及使用其的方法
KR101418404B1 (ko) *	2012-01-06	2014-07-10	한미약품 주식회사	레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
AU2014249456B2 (en)	2013-03-13	2018-08-09	IRR, Inc.	Use of levocetirizine and montelukast in the treatment of autoimmune disorders
CN105307655B (zh)	2013-03-13	2019-05-03	弗拉特利发现实验室有限责任公司	哒嗪酮化合物及其用于制备治疗囊肿状纤维化的药物的应用
KR101555908B1 (ko) *	2013-12-19	2015-09-25	한미약품 주식회사	몬테루카스트 또는 이의 약제학적으로 허용 가능한 염을 포함하는 액상 제제 및 이의 제조방법
CN106456624B (zh)	2014-02-04	2020-05-22	生物制药合伙公司	Flap抑制剂的降低中枢神经***内的神经炎症介导的损伤的应用
JP2017526728A (ja)	2014-09-15	2017-09-14	インフラマトリー・レスポンス・リサーチ・インコーポレイテッド	炎症介在性状態の治療におけるレボセチリジン及びモンテルカスト
WO2020146822A1 (en) *	2019-01-11	2020-07-16	Naegis Pharmaceuticals Inc.	Leukotriene synthesis inhibitors
CN110721189A (zh) *	2019-11-19	2020-01-24	贵州云峰药业有限公司	一种皮肤消毒剂
BR112022015199A2 (pt)	2020-02-03	2022-10-11	Taro Pharma Ind	Formulações tópicas de montelucaste
CN116284470B (zh) *	2023-02-15	2024-08-02	广西中医药大学	一种海蛇尾多糖硫酸酯衍生物的制备方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3813384A (en)	1972-01-17	1974-05-28	Asta Werke Ag Chem Fab	Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
EP0316633B1 (de)	1987-11-13	1993-01-27	ASTA Medica Aktiengesellschaft	Azelastin enthaltende Arzneimittel zur Anwendung in der Nase und/oder am Auge
EP0402422A1 (en)	1988-04-27	1990-12-19	Schering Corporation	Certain paf antagonist antihistamine combinations and methods
GB2284351B (en) *	1992-08-03	1996-11-27	Sepracor Inc	Terfenadine metabolites and their optically pure isomers for treating allergic disorders
IL125446A0 (en) *	1996-02-08	1999-03-12	Merck & Co Inc	Pharmaceutical composition for the treatment of asthma allergy and inflammation
DE19610882A1 (de) *	1996-03-20	1997-09-25	Dresden Arzneimittel	Neue 1,3,5-trisubstituierte Indazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5900421A (en) *	1997-02-11	1999-05-04	Sepracor Inc.	Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
CA2281789A1 (en) *	1997-04-30	1998-11-05	Warner-Lambert Company	Topical nasal antiinflammatory compositions
US6242179B1 (en) *	1997-12-17	2001-06-05	Incyte Pharmaceuticals, Inc.	Human phosphatases
CZ301349B6 (cs) *	1997-12-23	2010-01-27	Schering Corporation	Prostredek k lécbe respiracních a kožních onemocnení, který obsahuje alespon jednoho antagonistu leukotrienu a alespon jedno antihistaminikum
US6194431B1 (en) *	1998-04-14	2001-02-27	Paul D. Rubin	Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors

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Also Published As

Publication number	Publication date
MXPA02008064A (es)	2004-04-05
JP5529362B2 (ja)	2014-06-25
CN1241569C (zh)	2006-02-15
HU228927B1 (en)	2013-06-28
ES2236189T3 (es)	2005-07-16
EP1265615B1 (de)	2005-01-19
AU781177B2 (en)	2005-05-12
CZ20022700A3 (cs)	2002-11-13
PL198357B1 (pl)	2008-06-30
JP2003522803A (ja)	2003-07-29
EP1265615A2 (de)	2002-12-18
US20010025040A1 (en)	2001-09-27
KR20020083161A (ko)	2002-11-01
RU2002123345A (ru)	2004-03-20
BR0108445A (pt)	2003-04-01
ATE287266T1 (de)	2005-02-15
AR027528A1 (es)	2003-04-02
IL151106A0 (en)	2003-04-10
AU4058401A (en)	2001-08-27
PT1265615E (pt)	2005-05-31
DE10007203A1 (de)	2001-08-23
NO328153B1 (no)	2009-12-21
DK1265615T3 (da)	2005-05-30
ZA200206575B (en)	2003-05-14
TWI296525B (en)	2008-05-11
IL151106A (en)	2008-06-05
DE50105126D1 (de)	2005-02-24
UA72587C2 (uk)	2005-03-15
HUP0204079A3 (en)	2006-07-28
WO2001060407A3 (de)	2002-03-07
CZ296395B6 (cs)	2006-03-15
NO20023818D0 (no)	2002-08-12
RU2292208C2 (ru)	2007-01-27
NZ520470A (en)	2004-05-28
HUP0204079A2 (hu)	2003-04-28
NO20023818L (no)	2002-08-12
CN1400903A (zh)	2003-03-05
HK1053792A1 (en)	2003-11-07
US6436924B2 (en)	2002-08-20
WO2001060407A2 (de)	2001-08-23
KR100764329B1 (ko)	2007-10-05
PL355818A1 (en)	2004-05-17
SK11752002A3 (sk)	2002-11-06

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2017-11-03	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20170205

Publication	Publication Date	Title
SK285990B6 (sk)	2008-01-07	Kombinácia nesedatívnych antihistaminík so substanciami, ktoré ovplyvňujú pôsobenie leukotriénu, naošetrovanie rinitídy/konjunktivitídy
US20020037297A1 (en)	2002-03-28	Process for the topical treatment of rhinitis, conjunctivitis cold, and cold-like and flu symptoms
JP2012001558A (ja)	2012-01-05	ロテプレドノールと抗ヒスタミン薬の新規な組み合わせ物
US20060110449A1 (en)	2006-05-25	Pharmaceutical composition
US20050222102A1 (en)	2005-10-06	Treatment of rhinitis with anticholinergics alone or in combination with antihistamines, phosphodiesterase 4 inhibitors, or corticosteroids
US20040176419A1 (en)	2004-09-09	Composition comprising a pde-4 inhibitor and h1-receptor antagonist and the use thereof for the manufacture of a medicament for the treatment of respiratory diseases
CA2688542C (en)	2016-07-12	Methods and compositions for administration of oxybutynin
WO2004019955A1 (en)	2004-03-11	The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis
CA2337571C (en)	2009-12-22	Antihistamine leukotriene combinations
AU3640999A (en)	1999-11-01	Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
MXPA06008935A (en)	2006-12-13	Treatment of rhinitis with anticholinergics alone in combination with antihistamines phosphodiesterase 4 inhibitors, or corticosteroids