SK16912001A3 - Viacstupňový spôsob výroby mikrokapsúl plnených plynom - Google Patents

Viacstupňový spôsob výroby mikrokapsúl plnených plynom Download PDF

Info

Publication number: SK16912001A3
Authority: SK; Slovakia
Prior art keywords: poly; oxyethylene; process according; carried out; microcapsules
Prior art date: 1999-05-27

Application number

SK1691-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Uwe Budde

Andreas Briel

Georg R�Ssling

Kai Lovis

Wolfgang Schmidt

Hans-Ulrich Moritz

Michael Gottfried

Jan-Peter Ingwersen

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-27

Filing date

2000-05-23

Publication date

2002-04-04

2000-05-23 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2002-04-04 Publication of SK16912001A3 publication Critical patent/SK16912001A3/sk

Links

239000003094 microcapsule Substances 0.000 title claims abstract description 69
238000004519 manufacturing process Methods 0.000 title claims abstract description 56
238000000034 method Methods 0.000 claims abstract description 54
230000008569 process Effects 0.000 claims abstract description 41
238000006116 polymerization reaction Methods 0.000 claims abstract description 36
238000003756 stirring Methods 0.000 claims abstract description 11
-1 poly (oxyethylene) sulfate Polymers 0.000 claims description 43
239000002245 particle Substances 0.000 claims description 25
238000006243 chemical reaction Methods 0.000 claims description 24
229920000642 polymer Polymers 0.000 claims description 24
239000006185 dispersion Substances 0.000 claims description 23
238000002156 mixing Methods 0.000 claims description 23
239000000178 monomer Substances 0.000 claims description 22
230000015572 biosynthetic process Effects 0.000 claims description 21
239000012429 reaction media Substances 0.000 claims description 16
235000014113 dietary fatty acids Nutrition 0.000 claims description 15
229930195729 fatty acid Natural products 0.000 claims description 15
239000000194 fatty acid Substances 0.000 claims description 15
239000004094 surface-active agent Substances 0.000 claims description 15
239000000243 solution Substances 0.000 claims description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
239000004815 dispersion polymer Substances 0.000 claims description 10
229920002451 polyvinyl alcohol Polymers 0.000 claims description 10
239000011859 microparticle Substances 0.000 claims description 9
238000010276 construction Methods 0.000 claims description 8
150000002148 esters Chemical class 0.000 claims description 8
125000006353 oxyethylene group Chemical group 0.000 claims description 8
239000011541 reaction mixture Substances 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 7
238000002309 gasification Methods 0.000 claims description 7
229920001577 copolymer Polymers 0.000 claims description 6
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 6
235000019422 polyvinyl alcohol Nutrition 0.000 claims description 6
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
108010010803 Gelatin Proteins 0.000 claims description 5
150000004665 fatty acids Chemical class 0.000 claims description 5
229920000159 gelatin Polymers 0.000 claims description 5
239000008273 gelatin Substances 0.000 claims description 5
235000019322 gelatine Nutrition 0.000 claims description 5
235000011852 gelatine desserts Nutrition 0.000 claims description 5
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
102000008100 Human Serum Albumin Human genes 0.000 claims description 4
108091006905 Human Serum Albumin Proteins 0.000 claims description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
230000002378 acidificating effect Effects 0.000 claims description 4
239000004359 castor oil Substances 0.000 claims description 4
235000019438 castor oil Nutrition 0.000 claims description 4
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
239000003929 acidic solution Substances 0.000 claims description 3
150000007513 acids Chemical class 0.000 claims description 3
239000012298 atmosphere Substances 0.000 claims description 3
239000003795 chemical substances by application Substances 0.000 claims description 3
239000008389 polyethoxylated castor oil Substances 0.000 claims description 3
229920002307 Dextran Polymers 0.000 claims description 2
229930006000 Sucrose Natural products 0.000 claims description 2
239000000654 additive Substances 0.000 claims description 2
230000002776 aggregation Effects 0.000 claims description 2
238000004220 aggregation Methods 0.000 claims description 2
150000001447 alkali salts Chemical class 0.000 claims description 2
229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
229920001400 block copolymer Polymers 0.000 claims description 2
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
150000002191 fatty alcohols Chemical class 0.000 claims description 2
235000011187 glycerol Nutrition 0.000 claims description 2
230000007062 hydrolysis Effects 0.000 claims description 2
238000006460 hydrolysis reaction Methods 0.000 claims description 2
229920000847 nonoxynol Polymers 0.000 claims description 2
SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical class CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims description 2
229920001983 poloxamer Polymers 0.000 claims description 2
230000000379 polymerizing effect Effects 0.000 claims description 2
239000005720 sucrose Substances 0.000 claims description 2
150000005846 sugar alcohols Polymers 0.000 claims description 2
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical class CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 claims description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
229920002858 MOWIOL ® 4-88 Polymers 0.000 claims 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
230000000996 additive effect Effects 0.000 claims 1
125000005250 alkyl acrylate group Chemical group 0.000 claims 1
125000002877 alkyl aryl group Chemical class 0.000 claims 1
YZFWTZACSRHJQD-UHFFFAOYSA-N ciglitazone Chemical compound C=1C=C(CC2C(NC(=O)S2)=O)C=CC=1OCC1(C)CCCCC1 YZFWTZACSRHJQD-UHFFFAOYSA-N 0.000 claims 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
229940072106 hydroxystearate Drugs 0.000 claims 1
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 1
229960003511 macrogol Drugs 0.000 claims 1
239000011780 sodium chloride Substances 0.000 claims 1
239000000126 substance Substances 0.000 abstract description 8
239000007789 gas Substances 0.000 description 50
239000002609 medium Substances 0.000 description 17
239000007788 liquid Substances 0.000 description 11
239000012071 phase Substances 0.000 description 10
239000002872 contrast media Substances 0.000 description 8
239000002904 solvent Substances 0.000 description 8
239000000725 suspension Substances 0.000 description 8
238000009826 distribution Methods 0.000 description 7
238000002604 ultrasonography Methods 0.000 description 7
238000007792 addition Methods 0.000 description 6
230000008901 benefit Effects 0.000 description 5
JJJFUHOGVZWXNQ-UHFFFAOYSA-N enbucrilate Chemical compound CCCCOC(=O)C(=C)C#N JJJFUHOGVZWXNQ-UHFFFAOYSA-N 0.000 description 5
239000011521 glass Substances 0.000 description 5
229920002113 octoxynol Polymers 0.000 description 5
229940066429 octoxynol Drugs 0.000 description 5
239000003960 organic solvent Substances 0.000 description 5
239000008215 water for injection Substances 0.000 description 5
239000011248 coating agent Substances 0.000 description 4
230000000694 effects Effects 0.000 description 4
238000005188 flotation Methods 0.000 description 4
239000006260 foam Substances 0.000 description 4
239000004816 latex Substances 0.000 description 4
229920000126 latex Polymers 0.000 description 4
239000000203 mixture Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
230000001133 acceleration Effects 0.000 description 3
238000005273 aeration Methods 0.000 description 3
238000000576 coating method Methods 0.000 description 3
238000005187 foaming Methods 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
238000012545 processing Methods 0.000 description 3
230000035484 reaction time Effects 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 description 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
208000007536 Thrombosis Diseases 0.000 description 2
150000001299 aldehydes Chemical class 0.000 description 2
125000005907 alkyl ester group Chemical group 0.000 description 2
230000000747 cardiac effect Effects 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
230000004087 circulation Effects 0.000 description 2
229940039231 contrast media Drugs 0.000 description 2
238000011161 development Methods 0.000 description 2
238000002592 echocardiography Methods 0.000 description 2
230000007717 exclusion Effects 0.000 description 2
238000001914 filtration Methods 0.000 description 2
230000006872 improvement Effects 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000000523 sample Substances 0.000 description 2
238000001694 spray drying Methods 0.000 description 2
238000011146 sterile filtration Methods 0.000 description 2
YNDGLMYLSGEDHX-UHFFFAOYSA-N 1,2,4,3-trioxathiane 3,3-dioxide Chemical compound O=S1(=O)OCCOO1 YNDGLMYLSGEDHX-UHFFFAOYSA-N 0.000 description 1
JYFREZOLRUHBAQ-UHFFFAOYSA-N 2-cyano-4-methylpent-2-enoic acid Chemical class CC(C)C=C(C#N)C(O)=O JYFREZOLRUHBAQ-UHFFFAOYSA-N 0.000 description 1
NTDQQZYCCIDJRK-UHFFFAOYSA-N 4-octylphenol Chemical compound CCCCCCCCC1=CC=C(O)C=C1 NTDQQZYCCIDJRK-UHFFFAOYSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
238000001069 Raman spectroscopy Methods 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
150000001253 acrylic acids Chemical class 0.000 description 1
239000012190 activator Substances 0.000 description 1
230000003044 adaptive effect Effects 0.000 description 1
238000013019 agitation Methods 0.000 description 1
208000026935 allergic disease Diseases 0.000 description 1
230000007815 allergy Effects 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
238000007707 calorimetry Methods 0.000 description 1
229920001688 coating polymer Polymers 0.000 description 1
238000001246 colloidal dispersion Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000007872 degassing Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
230000026058 directional locomotion Effects 0.000 description 1
239000002612 dispersion medium Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
238000011049 filling Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
239000007792 gaseous phase Substances 0.000 description 1
210000003709 heart valve Anatomy 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000033001 locomotion Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
238000004886 process control Methods 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000010802 sludge Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000005507 spraying Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000010959 steel Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
230000008685 targeting Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000002792 vascular Effects 0.000 description 1
238000012800 visualization Methods 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
- Y10T428/2987—Addition polymer from unsaturated monomers only

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Radiology & Medical Imaging (AREA)
Acoustics & Sound (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Manufacturing Of Micro-Capsules (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Polymerisation Methods In General (AREA)
Medicinal Preparation (AREA)

SK1691-2001A 1999-05-27 2000-05-23 Viacstupňový spôsob výroby mikrokapsúl plnených plynom SK16912001A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19925311A DE19925311B4 (de)	1999-05-27	1999-05-27	Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln
PCT/DE2000/001678 WO2000072888A1 (de)	1999-05-27	2000-05-23	Mehrstufen-verfahren zur herstellung von gasgefüllten mikrokapseln

Publications (1)

Publication Number	Publication Date
SK16912001A3 true SK16912001A3 (sk)	2002-04-04

Family

ID=7910041

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1691-2001A SK16912001A3 (sk)	1999-05-27	2000-05-23	Viacstupňový spôsob výroby mikrokapsúl plnených plynom

Country Status (29)

Country	Link
US (1)	US6652782B1 (no)
EP (1)	EP1180043B1 (no)
JP (1)	JP2003500458A (no)
KR (1)	KR100681369B1 (no)
CN (1)	CN1189218C (no)
AT (1)	ATE245034T1 (no)
AU (1)	AU766705B2 (no)
BG (1)	BG106137A (no)
BR (1)	BR0011543A (no)
CA (1)	CA2373869A1 (no)
CZ (1)	CZ297351B6 (no)
DE (2)	DE19925311B4 (no)
DK (1)	DK1180043T3 (no)
EA (1)	EA004220B1 (no)
EE (1)	EE200100630A (no)
ES (1)	ES2203496T3 (no)
HK (1)	HK1050492A1 (no)
HR (1)	HRP20010942A2 (no)
HU (1)	HUP0201640A2 (no)
IL (1)	IL146466A0 (no)
MX (1)	MXPA01011998A (no)
NO (1)	NO322312B1 (no)
NZ (1)	NZ515147A (no)
PL (1)	PL195106B1 (no)
PT (1)	PT1180043E (no)
SK (1)	SK16912001A3 (no)
WO (1)	WO2000072888A1 (no)
YU (1)	YU84101A (no)
ZA (1)	ZA200110482B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19952738A1 (de) *	1999-10-27	2001-05-23	Schering Ag	Verbesserte Suspensionen von Ultraschallkontrastmitteln
DE10065068A1 (de) *	2000-12-21	2002-07-04	Schering Ag	Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln mit definiert enger Größenverteilung durch definierte Fremdbegasung während des Mikrokapselaufbaus
SE0302794D0 (sv) *	2003-10-24	2003-10-24	Per Hansson	Novel microparticles for ultrasound contrast imaging and drug delivery
DE602005021057D1 (de)	2004-01-20	2010-06-17	Toronto E	Hochfrequenz-ultraschall-darstellung mit kontrastmitteln
CN1984708B (zh) *	2004-06-29	2014-01-29	皇家飞利浦电子股份有限公司	微球体
ITMI20110784A1 (it) *	2011-05-09	2012-11-10	Sipcam Spa	Processo per l'ottenimento di microcapsule

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1170569A (en) *	1980-11-17	1984-07-10	Julia S. Rasor	Microbubble precursors and methods for their production and use
DE4219724A1 (de) *	1992-06-13	1993-12-16	Schering Ag	Verwendung von Mikrokapseln als Kontrastmittel für die Farbdoppler-Sonographie
HU221485B (en) *	1988-02-05	2002-10-28	Schering Ag	Ultrasound contrast media consisting of microparticles and process for producing the same
DE4004430A1 (de)	1990-02-09	1991-08-14	Schering Ag	Aus polyaldehyden aufgebaute kontrastmittel
DE4219723A1 (de)	1992-06-13	1993-12-16	Schering Ag	Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
DE4232755A1 (de)	1992-09-26	1994-03-31	Schering Ag	Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren
US6068857A (en) *	1993-09-09	2000-05-30	Schering Aktiengesellchaft	Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production
DE4403789A1 (de) *	1994-02-03	1995-08-10	Schering Ag	Mittel zur visuellen Markierung von Körpergewebe
NO940711D0 (no) *	1994-03-01	1994-03-01	Nycomed Imaging As	Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
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DE19648663A1 (de)	1996-11-14	1998-05-28	Schering Ag	Flüssigkeitsgefüllte Mikropartikel mit neuem Wirkungsprinzip und deren Verwendung als Diagnostika und Therapeutika

1999
- 1999-05-27 DE DE19925311A patent/DE19925311B4/de not_active Expired - Fee Related
2000
- 2000-05-23 IL IL14646600A patent/IL146466A0/xx unknown
- 2000-05-23 WO PCT/DE2000/001678 patent/WO2000072888A1/de active IP Right Grant
- 2000-05-23 US US09/979,554 patent/US6652782B1/en not_active Expired - Fee Related
- 2000-05-23 DE DE50002914T patent/DE50002914D1/de not_active Expired - Fee Related
- 2000-05-23 MX MXPA01011998A patent/MXPA01011998A/es active IP Right Grant
- 2000-05-23 ES ES00945561T patent/ES2203496T3/es not_active Expired - Lifetime
- 2000-05-23 JP JP2000620994A patent/JP2003500458A/ja active Pending
- 2000-05-23 AT AT00945561T patent/ATE245034T1/de not_active IP Right Cessation
- 2000-05-23 HU HU0201640A patent/HUP0201640A2/hu unknown
- 2000-05-23 CA CA002373869A patent/CA2373869A1/en not_active Abandoned
- 2000-05-23 BR BR0011543-6A patent/BR0011543A/pt not_active IP Right Cessation
- 2000-05-23 EA EA200101154A patent/EA004220B1/ru not_active IP Right Cessation
- 2000-05-23 EP EP00945561A patent/EP1180043B1/de not_active Expired - Lifetime
- 2000-05-23 SK SK1691-2001A patent/SK16912001A3/sk unknown
- 2000-05-23 KR KR1020017015097A patent/KR100681369B1/ko not_active IP Right Cessation
- 2000-05-23 EE EEP200100630A patent/EE200100630A/xx unknown
- 2000-05-23 AU AU59627/00A patent/AU766705B2/en not_active Ceased
- 2000-05-23 YU YU84101A patent/YU84101A/sh unknown
- 2000-05-23 CZ CZ20014235A patent/CZ297351B6/cs not_active IP Right Cessation
- 2000-05-23 NZ NZ515147A patent/NZ515147A/en unknown
- 2000-05-23 PT PT00945561T patent/PT1180043E/pt unknown
- 2000-05-23 CN CNB008110212A patent/CN1189218C/zh not_active Expired - Fee Related
- 2000-05-23 DK DK00945561T patent/DK1180043T3/da active
- 2000-05-23 PL PL00351873A patent/PL195106B1/pl not_active IP Right Cessation
2001
- 2001-11-23 BG BG106137A patent/BG106137A/bg unknown
- 2001-11-26 NO NO20015745A patent/NO322312B1/no unknown
- 2001-12-20 ZA ZA200110482A patent/ZA200110482B/en unknown
- 2001-12-21 HR HR20010942A patent/HRP20010942A2/hr not_active Application Discontinuation
2003
- 2003-04-15 HK HK03102710A patent/HK1050492A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EE200100630A (et)	2003-02-17
HUP0201640A2 (en)	2002-08-28
AU5962700A (en)	2000-12-18
NZ515147A (en)	2003-07-25
DE50002914D1 (de)	2003-08-21
CZ297351B6 (cs)	2006-11-15
DE19925311A1 (de)	2000-11-30
CA2373869A1 (en)	2000-12-07
NO322312B1 (no)	2006-09-11
EP1180043A1 (de)	2002-02-20
EP1180043B1 (de)	2003-07-16
CN1377284A (zh)	2002-10-30
ES2203496T3 (es)	2004-04-16
YU84101A (sh)	2004-07-15
CN1189218C (zh)	2005-02-16
BG106137A (bg)	2002-07-31
AU766705B2 (en)	2003-10-23
DE19925311B4 (de)	2004-06-09
EA004220B1 (ru)	2004-02-26
PL195106B1 (pl)	2007-08-31
HK1050492A1 (en)	2003-06-27
NO20015745L (no)	2002-01-08
MXPA01011998A (es)	2002-06-04
CZ20014235A3 (cs)	2002-04-17
NO20015745D0 (no)	2001-11-26
KR100681369B1 (ko)	2007-02-12
EA200101154A1 (ru)	2002-06-27
PT1180043E (pt)	2003-11-28
PL351873A1 (en)	2003-06-30
ATE245034T1 (de)	2003-08-15
KR20020013894A (ko)	2002-02-21
DK1180043T3 (da)	2003-11-10
IL146466A0 (en)	2002-07-25
BR0011543A (pt)	2002-03-05
US6652782B1 (en)	2003-11-25
JP2003500458A (ja)	2003-01-07
ZA200110482B (en)	2003-04-24
HRP20010942A2 (en)	2003-12-31
WO2000072888A1 (de)	2000-12-07

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