SI9500270B - Rekombinantni mersacidin in postopek za izdelavo - Google Patents

Rekombinantni mersacidin in postopek za izdelavo Download PDF

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Publication number
SI9500270B
SI9500270B SI9500270A SI9500270A SI9500270B SI 9500270 B SI9500270 B SI 9500270B SI 9500270 A SI9500270 A SI 9500270A SI 9500270 A SI9500270 A SI 9500270A SI 9500270 B SI9500270 B SI 9500270B
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SI
Slovenia
Prior art keywords
amino acid
dna
premersacidin
mersacidin
promersacidin
Prior art date
Application number
SI9500270A
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English (en)
Other versions
SI9500270A (en
Inventor
Klaus-Peter Koller
Hans Georg Sahl
Gabriele Bierbaum
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of SI9500270A publication Critical patent/SI9500270A/sl
Publication of SI9500270B publication Critical patent/SI9500270B/sl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (7)

  1. PATENTNI ZAHTEVKI 1. DNA, označena s tem, da kodira premersacidin z aminokislinsko sekvenco, prikazano na sl. 2, od aminokisline št. 1 do 68 (SEQ ID NO: 1).
  2. 2. DNA, označena s tem, da kodira premersacidin z nukleinsko kislinsko sekvenco, kot je prikazana na sl. 2, od nukleinske kisline št. 22 do 225 (SEQ ID NO: 3).
  3. 3. DNA, označena s tem, da kodira promersacidin z aminokislinsko sekvenco, prikazano na sl. 2, od aminokisline št. 49 do 68 (SEQ ID NO: 2).
  4. 4. DNA, označena s tem, da kodira promersacidin z nukleinsko kislinsko sekvenco, kot je prikazana na sl. 2, od nukleinske kisline št. 166 do 225 (SEQ ID NO: 4).
  5. 5. Vektor, označen s tem, da vsebuje DNA po enem od zahtevkov 1, 2, 3 ali 4.
  6. 6. Gostiteljska celica, označena s tem, da vsebuje vektor po zahtevku 5.
  7. 7. Postopek za izdelavo premersacidina, promersacidina ali zrelega mersacidina, označen s tem, da obsega stopnje: (a) kultiviranje prikladne gostiteljske celice, ki vsebuje DNA sekvenco po zahtevkih 1-4, pri prikladnih pogojih; in (b) izoliranje premersacidina, promersacidina ali zrelega mersacidina.
SI9500270A 1994-09-12 1995-09-01 Rekombinantni mersacidin in postopek za izdelavo SI9500270B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94114298A EP0700998B1 (en) 1994-09-12 1994-09-12 Recombinant mersacidin and a method for production

Publications (2)

Publication Number Publication Date
SI9500270A SI9500270A (en) 1996-04-30
SI9500270B true SI9500270B (sl) 2002-02-28

Family

ID=8216276

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9500270A SI9500270B (sl) 1994-09-12 1995-09-01 Rekombinantni mersacidin in postopek za izdelavo

Country Status (19)

Country Link
US (1) US5667991A (sl)
EP (1) EP0700998B1 (sl)
JP (1) JPH0898695A (sl)
KR (1) KR100394289B1 (sl)
CN (1) CN1149287C (sl)
AT (1) ATE255165T1 (sl)
AU (1) AU696450B2 (sl)
CA (1) CA2157975C (sl)
CZ (1) CZ285741B6 (sl)
DE (1) DE69433357T2 (sl)
DK (1) DK0700998T3 (sl)
ES (1) ES2207636T3 (sl)
FI (1) FI120100B (sl)
HU (1) HU216619B (sl)
IL (1) IL115242A0 (sl)
NZ (1) NZ272960A (sl)
PT (1) PT700998E (sl)
RU (1) RU2198924C2 (sl)
SI (1) SI9500270B (sl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1694020B1 (en) * 1999-03-12 2008-05-28 Aware, Inc. Multicarrier modulation system and method
US6775320B1 (en) * 1999-03-12 2004-08-10 Aware, Inc. Method and a multi-carrier transceiver supporting dynamic switching between active application sets
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
US7592308B2 (en) 2004-03-26 2009-09-22 Novacta Biosystems Limited F3W variants of the lantibiotic mersacidin and its use
GB0406870D0 (en) * 2004-03-26 2004-04-28 Novacta Biosystems Ltd Improvements relating to the production of lantibiotics
JP2009509519A (ja) * 2005-09-27 2009-03-12 ノヴァクタ バイオシステムズ リミティッド ランチビオティックメルサシジンの変種およびそれらの使用
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
CA2720173A1 (en) * 2008-04-02 2009-10-08 Sanofi-Aventis Highly bridged peptides from actinomadura namibiensis
RU2506272C2 (ru) * 2008-11-24 2014-02-10 Сентинелла Фармасьютикалз, Инк. ("Сентинелла") Лантибиотические карбоксиамидные производные с усиленной антибактериальной активностью
NZ594011A (en) 2009-01-14 2013-12-20 Novacta Biosystems Ltd Deoxyactagardine derivatives
WO2010089544A1 (en) 2009-02-04 2010-08-12 Novacta Biosystems Limited Actagardine derivatives
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
CN106188253B (zh) * 2016-08-26 2020-08-18 上海交通大学 抗菌肽Lexapeptide及其制备方法和用途
CN113677799A (zh) 2019-02-05 2021-11-19 伊兰科美国公司 一种遗传修饰乳酸杆菌及其应用
CN111235119B (zh) * 2020-03-05 2021-11-23 苏州十一方生物科技有限公司 一种融合抗菌蛋白的制备及应用
CN114457102B (zh) * 2022-02-24 2023-12-26 重庆市畜牧科学院 用于编码分泌型Mersacidin的基因表达盒及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5218101A (en) * 1988-07-05 1993-06-08 The University Of Maryland Leader sequence inducing a post-translational modification of polypeptides in bacteria, and gene therefor
IN167138B (sl) * 1988-08-17 1990-09-01 Hoechst India

Also Published As

Publication number Publication date
KR960010863A (ko) 1996-04-20
CN1131192A (zh) 1996-09-18
ES2207636T3 (es) 2004-06-01
DE69433357D1 (de) 2004-01-08
AU3055495A (en) 1996-03-28
DE69433357T2 (de) 2004-09-09
EP0700998A1 (en) 1996-03-13
US5667991A (en) 1997-09-16
DK0700998T3 (da) 2004-03-29
HU9502643D0 (en) 1995-11-28
FI120100B (fi) 2009-06-30
SI9500270A (en) 1996-04-30
JPH0898695A (ja) 1996-04-16
IL115242A0 (en) 1995-12-31
HUT73800A (en) 1996-09-30
CZ231895A3 (en) 1996-03-13
KR100394289B1 (ko) 2003-10-22
CA2157975A1 (en) 1996-03-13
NZ272960A (en) 1996-05-28
ATE255165T1 (de) 2003-12-15
FI954220A0 (fi) 1995-09-08
HU216619B (hu) 1999-07-28
PT700998E (pt) 2004-03-31
RU2198924C2 (ru) 2003-02-20
CA2157975C (en) 2008-11-18
EP0700998B1 (en) 2003-11-26
AU696450B2 (en) 1998-09-10
CZ285741B6 (cs) 1999-10-13
FI954220A (fi) 1996-03-13
CN1149287C (zh) 2004-05-12

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