SI3183264T1 - Metoda pegilacije - Google Patents

Metoda pegilacije

Info

Publication number
SI3183264T1
SI3183264T1 SI201531401T SI201531401T SI3183264T1 SI 3183264 T1 SI3183264 T1 SI 3183264T1 SI 201531401 T SI201531401 T SI 201531401T SI 201531401 T SI201531401 T SI 201531401T SI 3183264 T1 SI3183264 T1 SI 3183264T1
Authority
SI
Slovenia
Prior art keywords
pegylation method
pegylation
Prior art date
Application number
SI201531401T
Other languages
English (en)
Inventor
Robert S. Gronke
Orlando Jaquez
Original Assignee
Biogen Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc. filed Critical Biogen Ma Inc.
Publication of SI3183264T1 publication Critical patent/SI3183264T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI201531401T 2014-08-19 2015-08-18 Metoda pegilacije SI3183264T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461997000P 2014-08-19 2014-08-19
PCT/US2015/045678 WO2017030563A1 (en) 2014-08-19 2015-08-18 Pegylation method
EP15763443.7A EP3183264B1 (en) 2014-08-19 2015-08-18 Pegylation method

Publications (1)

Publication Number Publication Date
SI3183264T1 true SI3183264T1 (sl) 2021-03-31

Family

ID=59559468

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531401T SI3183264T1 (sl) 2014-08-19 2015-08-18 Metoda pegilacije

Country Status (12)

Country Link
US (1) US11318207B2 (sl)
EP (2) EP3183264B1 (sl)
CO (1) CO2017002512A2 (sl)
CY (1) CY1123685T1 (sl)
DK (1) DK3183264T3 (sl)
ES (1) ES2824028T3 (sl)
HR (1) HRP20201725T1 (sl)
LT (1) LT3183264T (sl)
MX (1) MX2017002140A (sl)
RS (1) RS61128B1 (sl)
SI (1) SI3183264T1 (sl)
WO (1) WO2017030563A1 (sl)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
EP0082481B2 (en) 1981-12-23 1990-09-12 Schering Corporation Stabilised alpha-interferon formulations and their preparation
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en) 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
JP2514950B2 (ja) 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
AU691225B2 (en) 1993-11-10 1998-05-14 Schering Corporation Improved interferon polymer conjugates
PL193352B1 (pl) 1998-04-28 2007-02-28 Applied Research Systems Koniugat poliol-interferon ß, sposób jego wytwarzania i jego zastosowanie oraz kompozycja farmaceutyczna
TWI266801B (en) 1999-07-26 2006-11-21 Applied Research Systems Polyol-IFN-beta conjugates
ME00239B (me) * 2002-01-18 2011-05-10 Biogen Ma Inc Polimerna jedinjenja polialkilena i njihova upotreba
DE60313786T2 (de) * 2002-09-27 2008-01-24 F. Hoffmann-La Roche Ag Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4
US20040180054A1 (en) * 2003-03-13 2004-09-16 Hanmi Pharm. Co., Ltd. Physiologically active polypeptide conjugate having prolonged in vivo half-life
CU23556A1 (es) 2005-11-30 2010-07-20 Ct Ingenieria Genetica Biotech Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
GB0908393D0 (en) 2009-05-15 2009-06-24 Almac Sciences Scotland Ltd Labelling method
EP2512489A4 (en) * 2009-12-15 2014-04-02 Merck Sharp & Dohme METHOD OF PREPARING ACADESINE
AR080993A1 (es) 2010-04-02 2012-05-30 Hanmi Holdings Co Ltd Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina
CN102453089B (zh) 2010-10-25 2014-06-04 北京凯因科技股份有限公司 重组集成干扰素变异体聚乙二醇偶联物的制备和应用
WO2014130811A1 (en) 2013-02-22 2014-08-28 Biogen Idec Ma Inc Interferon beta formulation
CN103113466B (zh) 2013-03-01 2015-06-03 中国科学院过程工程研究所 聚乙二醇修饰的重组人干扰素β-1b及制备方法
CN103936847B (zh) 2013-12-24 2014-12-10 北京凯因科技股份有限公司 Peg-sa及其药物组合物

Also Published As

Publication number Publication date
EP3183264A1 (en) 2017-06-28
WO2017030563A1 (en) 2017-02-23
MX2017002140A (es) 2017-08-21
CY1123685T1 (el) 2022-03-24
DK3183264T3 (da) 2020-11-02
ES2824028T3 (es) 2021-05-11
BR112017003162A2 (pt) 2017-11-28
HRP20201725T1 (hr) 2021-03-05
EP3183264B1 (en) 2020-07-29
EP3782652A1 (en) 2021-02-24
CO2017002512A2 (es) 2017-05-31
LT3183264T (lt) 2021-01-11
RS61128B1 (sr) 2020-12-31
WO2017030563A8 (en) 2017-03-16
US20170232111A1 (en) 2017-08-17
US11318207B2 (en) 2022-05-03

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