SI2438060T1 - Aktivni metabolit trombin receptorskega antagonista - Google Patents

Aktivni metabolit trombin receptorskega antagonista

Info

Publication number
SI2438060T1
SI2438060T1 SI201030420T SI201030420T SI2438060T1 SI 2438060 T1 SI2438060 T1 SI 2438060T1 SI 201030420 T SI201030420 T SI 201030420T SI 201030420 T SI201030420 T SI 201030420T SI 2438060 T1 SI2438060 T1 SI 2438060T1
Authority
SI
Slovenia
Prior art keywords
receptor antagonist
active metabolite
thrombin receptor
thrombin
metabolite
Prior art date
Application number
SI201030420T
Other languages
English (en)
Inventor
Natalia A. Penner
Kimberly Nguyen Voronin
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of SI2438060T1 publication Critical patent/SI2438060T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
SI201030420T 2009-06-04 2010-06-02 Aktivni metabolit trombin receptorskega antagonista SI2438060T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18414709P 2009-06-04 2009-06-04
EP10724627.4A EP2438060B1 (en) 2009-06-04 2010-06-02 Active metabolite of a thrombin receptor antagonist
PCT/US2010/036984 WO2010141525A1 (en) 2009-06-04 2010-06-02 Active metabolite of a thrombin receptor antagonist

Publications (1)

Publication Number Publication Date
SI2438060T1 true SI2438060T1 (sl) 2014-04-30

Family

ID=43012674

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201030420T SI2438060T1 (sl) 2009-06-04 2010-06-02 Aktivni metabolit trombin receptorskega antagonista

Country Status (15)

Country Link
US (1) US8575351B2 (sl)
EP (1) EP2438060B1 (sl)
JP (1) JP5789256B2 (sl)
AR (1) AR076967A1 (sl)
AU (1) AU2010256711B2 (sl)
CA (1) CA2764159A1 (sl)
DK (1) DK2438060T3 (sl)
ES (1) ES2437100T3 (sl)
HR (1) HRP20131049T1 (sl)
MX (1) MX2011012861A (sl)
PL (1) PL2438060T3 (sl)
PT (1) PT2438060E (sl)
SI (1) SI2438060T1 (sl)
TW (1) TW201109319A (sl)
WO (1) WO2010141525A1 (sl)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5150408A (en) 1991-02-27 1992-09-22 Motorola, Inc. Key distribution communication system
US7115632B1 (en) 1999-05-12 2006-10-03 G. D. Searle & Co. Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US6063847A (en) 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
TW434220B (en) 1998-02-02 2001-05-16 Shiseido Co Ltd 1,2-di-substituted piperidine derivative, a hair growth agent, and an agent for external use to the skin
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US20040192753A1 (en) 2000-06-15 2004-09-30 Samuel Chackalamannil Methods of use of thrombin receptor antagonists
US7488742B2 (en) 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
KR100604742B1 (ko) 2000-06-15 2006-07-26 쉐링 코포레이션 트롬빈 수용체 길항제
EP1436298B1 (en) 2001-10-18 2011-09-21 Schering Corporation Himbacine analogues as thrombin receptor antagonists
ATE494284T1 (de) * 2002-04-16 2011-01-15 Schering Corp Tricyclischer thrombinrezeptorantagonist
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
JP2009521472A (ja) 2005-12-22 2009-06-04 シェーリング コーポレイション 心肺手術の合併症の予防としてのトロンビンレセプターアンタゴニスト
JP2009542677A (ja) 2006-06-30 2009-12-03 シェーリング コーポレイション トロンビン受容体拮抗薬の固形製剤
TWI367112B (en) 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
TWI343262B (en) 2006-09-26 2011-06-11 Schering Corp Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
JP2010505842A (ja) * 2006-10-04 2010-02-25 シェーリング コーポレイション トロンビン受容体拮抗薬としての二環式誘導体および三環式誘導体
EP2078012A2 (en) * 2006-10-04 2009-07-15 Schering Corporation Thrombin receptor antagonists based on the modified tricyclic unit of himbacine

Also Published As

Publication number Publication date
EP2438060A1 (en) 2012-04-11
DK2438060T3 (da) 2014-01-13
JP5789256B2 (ja) 2015-10-07
JP2012528868A (ja) 2012-11-15
US8575351B2 (en) 2013-11-05
MX2011012861A (es) 2012-01-25
HRP20131049T1 (hr) 2013-12-06
TW201109319A (en) 2011-03-16
PT2438060E (pt) 2013-12-16
EP2438060B1 (en) 2013-10-02
PL2438060T3 (pl) 2014-03-31
WO2010141525A1 (en) 2010-12-09
AU2010256711A1 (en) 2012-01-12
US20120214845A1 (en) 2012-08-23
AU2010256711B2 (en) 2014-08-28
AR076967A1 (es) 2011-07-20
ES2437100T3 (es) 2014-01-08
CA2764159A1 (en) 2010-12-09

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