SI24094B - Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba - Google Patents

Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba Download PDF

Info

Publication number
SI24094B
SI24094B SI201200204A SI201200204A SI24094B SI 24094 B SI24094 B SI 24094B SI 201200204 A SI201200204 A SI 201200204A SI 201200204 A SI201200204 A SI 201200204A SI 24094 B SI24094 B SI 24094B
Authority
SI
Slovenia
Prior art keywords
antibacterial activity
materials
composite
metal
composites
Prior art date
Application number
SI201200204A
Other languages
English (en)
Other versions
SI24094A (sl
Inventor
Marija Vukomanović
Srečo Davor Škapin
Danilo Suvorov
Original Assignee
Institut "Jožef Stefan"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut "Jožef Stefan" filed Critical Institut "Jožef Stefan"
Priority to SI201200204A priority Critical patent/SI24094B/sl
Priority to PCT/SI2013/000025 priority patent/WO2013187846A1/en
Priority to EP13735469.2A priority patent/EP2863751B1/en
Publication of SI24094A publication Critical patent/SI24094A/sl
Publication of SI24094B publication Critical patent/SI24094B/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Ceramic Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Na osnovi novega koncepta smo izdelali človeku in naravi prijazen material, ki izkazuje antibakterijsko aktivnost. Ta material je kompozit, sestavljen iz biokeramične faze (hidroksiapatit), kovinske faze (zlato) in organske faze, ki vsebuje amino in tiolne skupine (aminokisline). Biokeramični del kompozita je nosilec (angl. templating agent), ki kontrolira rast in stabilnost kovinskih nano delcev. Kovinski nano delci imajo funkcionalizirano površino in so nosilci antibakterijske aktivnosti kompozitnega materiala. Učinkovitost antibakterijske aktivnosti kompozita zavisi od izbire površinske funkcionalizacije, ki zagotavlja antibakterijsko aktivnost proti gram-pozitivnim in gram-negativnim bakterijam. Izumljeni materiali izkazujejo višjo antibakterijsko aktivnost kot HAp/Ag kompoziti, kar kaže na možnost zamenjave strupenih materialov, ki vsebujejo Ag. Materiale smo pripravljali s sonokemijsko metodo, ki je bila razvita kot nova sintezna metoda za te materiale in spada v t.i. zeleno kemijo.

Claims (2)

  1. Patentni zahtevki
    1. Antibakterijski kompozit, pripravljen s sonokemijsko precipitacijo, pri čemer kompozit vključuje:
    a) hidroksiapatitni substrat,
    b) nanodelce zlata in
    c) organske molekule, pri čemer so nanodelci zlata pritrjeni na površino hidroksiapatitnega substrata; nanodelci zlata so prekriti z organskimi molekulami; organske molekule so izbrane iz skupine, ki jo sestavljajo arginin, glicin, anilin, histidin, 4 (metiltio) anilin in 5-bromopiridin-2-tioL
  2. 2. Postopek za pripravo antibakterijskega kompozita, ki vključuje:
    a) hidroksiapatitni substrat,
    b) nanodelce zlata in
    c) organske molekule, pri čemer so nanodelci zlata pritrjeni na površino hidroksiapatitnega substrata; nanodelci zlata so prekriti z organskimi molekulam; organske molekule so izbrane iz skupine, ki jo sestavljajo arginin, glicin, anilin, histidin, 4 (metiltio) anilin in 5-bromopiridin-2-tiol; priprava pa se izvaja s sonokemično precipitacijo.
SI201200204A 2012-06-15 2012-06-15 Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba SI24094B (sl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SI201200204A SI24094B (sl) 2012-06-15 2012-06-15 Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba
PCT/SI2013/000025 WO2013187846A1 (en) 2012-06-15 2013-05-08 Functionalized hydroxyapatite/gold composites as "green" materials with antibacterial activity and the process for preparing and use thereof
EP13735469.2A EP2863751B1 (en) 2012-06-15 2013-05-08 Functionalized hydroxyapatite/gold composites as "green" materials with antibacterial activity and the process for preparing and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI201200204A SI24094B (sl) 2012-06-15 2012-06-15 Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba

Publications (2)

Publication Number Publication Date
SI24094A SI24094A (sl) 2013-12-31
SI24094B true SI24094B (sl) 2021-07-30

Family

ID=48782583

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201200204A SI24094B (sl) 2012-06-15 2012-06-15 Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba

Country Status (3)

Country Link
EP (1) EP2863751B1 (sl)
SI (1) SI24094B (sl)
WO (1) WO2013187846A1 (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2013002101A1 (es) * 2013-07-23 2014-08-29 Univ Chile Aditivo que confiere propiedades biocidas a distintos materiales que comprende un material de soporte o portador modificado con un agente bacteriano que forma estructuras nanometricas sobre la superficie externa de dicho material de soporte; y metodo para preparacion de dicho aditivo.
CN114681481B (zh) * 2021-09-30 2023-05-02 合肥工业大学 一种用于选择性对抗***的手性二维硫纳米片及其制备方法和应用
CN113826643B (zh) * 2021-11-01 2022-07-05 烟台大学 银离子空间分布可控的载银羟基磷灰石微粒及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE302621T1 (de) 1999-06-14 2005-09-15 Imp College Innovations Ltd Silberhaltige bioglas-zusammensetzungen, die von sol-gel zuständen abgeleitet werden
JPWO2002030365A1 (ja) 2000-10-06 2004-02-19 株式会社サンギ 抗菌性樹脂
EP1985675B1 (en) 2002-06-04 2009-12-09 Fujitsu Limited Antibacterial paint for materials and materials coated therewith
ITTO20040854A1 (it) 2004-12-02 2005-03-02 Torino Politecnico Procedimento di funzionamento di superfici vetrose, vetroceramiche e ceramiche per la realizzazione di dispositivi impiantabili ad azione antibatterica
EP1919507A2 (en) 2005-08-04 2008-05-14 Thomas William Rademacher Nanoparticles comprising antibacterial ligands
WO2008066965A2 (en) 2006-06-23 2008-06-05 The Regents Of The University Of California Articles comprising large-surface-area bio-compatible materials and methods for making and using them
EP2136621B1 (en) 2007-04-04 2013-05-08 Perlen Converting AG Antimicrobial material
JP2009233653A (ja) 2008-03-06 2009-10-15 Daicel Chem Ind Ltd 表面銀固定化ハイドロキシアパタイト
JP2010082776A (ja) * 2008-10-01 2010-04-15 Tohoku Univ 有機溶媒ソノケミストリーによるナノ粒子合成法
US20100104652A1 (en) 2008-10-27 2010-04-29 University Of Arkansas Use of advanced nanomaterials for increasing sepecific cell functions
EP2229962A1 (en) 2009-03-20 2010-09-22 Laura Martelli Medical-surgical devices with antibacterial coating for human or animal implant and a method for their production
GB0906999D0 (en) 2009-04-23 2009-06-03 Promethean Particles Ltd Ceramic materials and method fo production
DE102009023459B4 (de) 2009-06-02 2017-08-31 Aap Implantate Ag Osteosynthese mit Nanosilber
US9192626B2 (en) 2009-06-10 2015-11-24 American Silver, Llc Dental uses of silver hydrosol
WO2011022642A1 (en) 2009-08-21 2011-02-24 Malshe Ajay P Nanostructured hydroxyapatite coating for dental and orthopedic implants

Also Published As

Publication number Publication date
EP2863751A1 (en) 2015-04-29
WO2013187846A1 (en) 2013-12-19
EP2863751B1 (en) 2018-07-25
SI24094A (sl) 2013-12-31

Similar Documents

Publication Publication Date Title
Li et al. Aggregation and dissolution of silver nanoparticles in natural surface water
Deng et al. Preparation of melamine sponge decorated with silver nanoparticles-modified graphene for water disinfection
Kamal Aminophenols formation from nitrophenols using agar biopolymer hydrogel supported CuO nanoparticles catalyst
Xu et al. Synthesis of magnetically separable Ag3PO4/TiO2/Fe3O4 heterostructure with enhanced photocatalytic performance under visible light for photoinactivation of bacteria
Cai et al. Bacteria-adsorbed palygorskite stabilizes the quaternary phosphonium salt with specific-targeting capability, long-term antibacterial activity, and lower cytotoxicity
IN2012DN01531A (sl)
SI24094B (sl) Kompozitni materiali na osnovi keramične faze in kovine s funkcionalizirano površino, kot okolju prijazni materiali z antibakterijskim delovanjem, metoda priprave in njihova uporaba
MX2016016617A (es) Tratamiento de mielomas.
RU2018134644A (ru) Дифференцировка in vitro плюрипотентных стволовых клеток в панкреатические эндодермальные клетки (пэк) и эндокринные клетки
NZ593870A (en) Coated powder composition of molecule encapsulated cyclopropene particles
MX2013011572A (es) Composicion farmaceutica.
JP2015525275A5 (sl)
CL2013002424A1 (es) Compuestos derivados de (piridin-4-il)-bencilamidas como moduladores alostericos de nachr alfa-7; composicion farmaceutica; proceso para preparar la composicion farmaceutica; y uso en el tratamiento de enfermedades como alzheimer, ansiedad, esquizofrenia, parkinson, entre otras.
CL2012003515A1 (es) Composición herbicida sinergica que comprende flazasulfuron o su sal y por lo menos un compuesto de urea seleccionado del grupo que consiste en tebutiuron, diuron y metobromuron; metodo para controlar plantas perjudiciales o inhibir su desarrollo que comprende aplicar dicha composicion.
WO2012143679A3 (en) Coating composition for pathogen control in cotton
Marchetti et al. Preparation of polyethylene composites containing silver (I) acylpyrazolonato additives and SAR investigation of their antibacterial activity
Yontar et al. Effects of plant extracts and green-synthesized silver nanoparticles on the polyvinyl alcohol (PVA) nanocomposite films
Assis et al. Polypropylene modified with Ag-based semiconductors as a potential material against SARS-CoV-2 and other pathogens
Farooq et al. Antibacterial Activity of Molybdenum Oxide–Polyacrylonitrile Composite Membrane with Fast Silver Ion Reduction
Lomora et al. Therapeutic applications of phytoplankton, with an emphasis on diatoms and coccolithophores
FR3041650B1 (fr) Substrat luminescent contenant des particules abrasives, et son procede de preparation
do Nascimento Silva Leandro et al. [Retracted] Silver Trimolybdate (Ag2Mo3O10. 2H2O) Nanorods: Synthesis, Characterization, and Photo‐Induced Antibacterial Activity under Visible‐Light Irradiation
Cao et al. “Cleaning” the surface of hydroxyapatite nanorods by a reaction-dissolution approach
TW201725226A (zh) 抗菌樹脂及其製作方法
HRP20230980T1 (hr) Regeneracija biougljika i/ili supstrat gnojiva

Legal Events

Date Code Title Description
OO00 Grant of patent

Effective date: 20140115

OU02 Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims

Effective date: 20210616