SI2195311T1 - Derivati piridina kot modulatorji receptorja s1p1/edg1 - Google Patents

Derivati piridina kot modulatorji receptorja s1p1/edg1

Info

Publication number: SI2195311T1
Authority: SI; Slovenia
Prior art keywords: receptor modulators; pyridine derivatives; edg1 receptor; edg1; pyridine
Prior art date: 2007-08-17

Application number

SI200830269T

Other languages

English (en)

Inventor

Martin Bolli

Cyrille Lescop

Boris Mathys

Claus Mueller

Oliver Nayler

Beat Steiner

Jorg Velker

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-17

Filing date

2008-08-14

Publication date

2011-07-29

2008-08-14 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2011-07-29 Publication of SI2195311T1 publication Critical patent/SI2195311T1/sl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Otolaryngology (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

SI200830269T 2007-08-17 2008-08-14 Derivati piridina kot modulatorji receptorja s1p1/edg1 SI2195311T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2007053293		2007-08-17
EP08789611A EP2195311B1 (en)	2007-08-17	2008-08-14	Pyridine derivatives as s1p1/edg1 receptor modulators
PCT/IB2008/053269 WO2009024905A1 (en)	2007-08-17	2008-08-14	Pyridine derivatives as s1p1/edg1 receptor modulators

Publications (1)

Publication Number	Publication Date
SI2195311T1 true SI2195311T1 (sl)	2011-07-29

Family

ID=40193868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200830269T SI2195311T1 (sl)	2007-08-17	2008-08-14	Derivati piridina kot modulatorji receptorja s1p1/edg1

Country Status (27)

Country	Link
US (1)	US8598208B2 (sl)
EP (1)	EP2195311B1 (sl)
JP (1)	JP5451614B2 (sl)
KR (1)	KR101541558B1 (sl)
CN (1)	CN102648198B (sl)
AR (1)	AR067977A1 (sl)
AT (1)	ATE502938T1 (sl)
AU (1)	AU2008290233B2 (sl)
BR (1)	BRPI0815190A2 (sl)
CA (1)	CA2695509A1 (sl)
CY (1)	CY1111830T1 (sl)
DE (1)	DE602008005770D1 (sl)
DK (1)	DK2195311T3 (sl)
ES (1)	ES2361463T3 (sl)
HK (1)	HK1144809A1 (sl)
HR (1)	HRP20110449T1 (sl)
MA (1)	MA31703B1 (sl)
MX (1)	MX2010001881A (sl)
MY (1)	MY153975A (sl)
NZ (1)	NZ583957A (sl)
PL (1)	PL2195311T3 (sl)
PT (1)	PT2195311E (sl)
RU (1)	RU2492168C2 (sl)
SI (1)	SI2195311T1 (sl)
TW (1)	TWI422373B (sl)
WO (1)	WO2009024905A1 (sl)
ZA (1)	ZA201001873B (sl)

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JP5253401B2 (ja) *	2006-09-07	2013-07-31	アクテリオンファーマシューティカルズリミテッド	免疫調節薬としてのピリジン−４−イル誘導体
PT2069335E (pt)	2006-09-08	2013-03-04	Actelion Pharmaceuticals Ltd	Derivados de piridin-3-ilo como agentes imunomoduladores
EP2079734A1 (en) *	2006-10-25	2009-07-22	NeuroSearch A/S	Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators
EP2125797B1 (en) *	2007-03-16	2014-01-15	Actelion Pharmaceuticals Ltd.	Amino- pyridine derivatives as s1p1 /edg1 receptor agonists
MY183039A (en) *	2008-03-07	2021-02-08	Idorsia Pharmaceuticals Ltd	Pyridin-2-yl derivatives as immunomodulating agents
AU2009227629B2 (en)	2008-03-17	2014-09-04	Actelion Pharmaceuticals Ltd	Dosing regimen for a selective S1P1 receptor agonist
EP2427416B1 (en) *	2009-05-04	2016-03-09	Prometic Pharma Smt Limited	Substituted aromatic compounds and pharmaceutical uses thereof
WO2011007324A1 (en)	2009-07-16	2011-01-20	Actelion Pharmaceuticals Ltd	Pyridin-4-yl derivatives
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EP2844655A1 (en)	2012-05-02	2015-03-11	Lupin Limited	Substituted pyridine compounds as crac modulators
JP6322630B2 (ja)	2012-08-17	2018-05-09	アクテリオンファーマシューティカルズリミテッドＡｃｔｅｌｉｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓＬｔｄ	（２Ｚ，５Ｚ）−５−（３−クロロ−４−（（Ｒ）−２，３−ジヒドロキシプロポキシ）ベンジリデン）−２−（プロピルイミノ）−３−（ｏ−トリル）チアゾリジン−４−オンの製造方法及び前記方法において使用される中間体
BR112015023161B1 (pt)	2013-03-15	2022-11-16	Idorsia Pharmaceuticals Ltd	Derivados de piridin-4-ila
CN107667104B (zh)	2015-05-20	2022-03-22	爱杜西亚药品有限公司	(s)-3-{4-[5-(2-环戊基-6-甲氧基-吡啶-4-基)-[1,2,4]噁二唑-3-基]-2-乙基-6-甲基-苯氧基}-丙烷-1,2-二醇的结晶形式
US10111841B2 (en)	2015-06-19	2018-10-30	University Of South Florida	Stabilization of alcohol intoxication-induced cardiovascular instability
WO2017004608A1 (en)	2015-07-02	2017-01-05	Exelixis, Inc.	Oxadiazole modulators of s1p methods of making and using
WO2017004609A1 (en)	2015-07-02	2017-01-05	Exelixis, Inc.	Thiadiazole modulators of s1p and methods of making and using
WO2017004610A1 (en)	2015-07-02	2017-01-05	Exelixis, Inc.	Tercyclic s1p3-sparing, s1p1 receptor agonists
EP4148053A1 (en)	2016-03-07	2023-03-15	The Global Alliance for TB Drug Development, Inc.	Antibacterial compounds and uses thereof
TW201808906A (zh)	2016-03-16	2018-03-16	拜耳作物科學股份有限公司	作為殺蟲劑之經取代吡啶化合物
US11186556B1 (en)	2018-10-16	2021-11-30	Celgene Corporation	Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Thiazolidinone and oxazolidinone compounds and formulations
US11013723B1 (en)	2018-10-16	2021-05-25	Celgene Corporation	Solid forms of a thiazolidinone compound, compositions and methods of use thereof
WO2022053994A1 (en) *	2020-09-11	2022-03-17	Pi Industries Limited	A process for the preparation of substituted pyridine compounds and intermediates thereof

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JP5253401B2 (ja)	2006-09-07	2013-07-31	アクテリオンファーマシューティカルズリミテッド	免疫調節薬としてのピリジン−４−イル誘導体
PT2069335E (pt)	2006-09-08	2013-03-04	Actelion Pharmaceuticals Ltd	Derivados de piridin-3-ilo como agentes imunomoduladores
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EP2125797B1 (en)	2007-03-16	2014-01-15	Actelion Pharmaceuticals Ltd.	Amino- pyridine derivatives as s1p1 /edg1 receptor agonists
NZ585775A (en)	2007-11-01	2011-12-22	Actelion Pharmaceuticals Ltd	Novel pyrimidine derivatives
CA2714665A1 (en)	2008-03-06	2009-09-11	Actelion Pharmaceuticals Ltd	Pyridine compounds
US20110046170A1 (en)	2008-03-06	2011-02-24	Martin Bolli	Novel pyrimidine-pyridine derivatives
MY183039A (en)	2008-03-07	2021-02-08	Idorsia Pharmaceuticals Ltd	Pyridin-2-yl derivatives as immunomodulating agents
KR20100125380A (ko)	2008-03-07	2010-11-30	액테리온 파마슈티칼 리미티드	신규한 아미노메틸 벤젠 유도체
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WO2011007324A1 (en)	2009-07-16	2011-01-20	Actelion Pharmaceuticals Ltd	Pyridin-4-yl derivatives

2008
- 2008-08-14 AU AU2008290233A patent/AU2008290233B2/en not_active Ceased
- 2008-08-14 NZ NZ583957A patent/NZ583957A/en not_active IP Right Cessation
- 2008-08-14 US US12/673,918 patent/US8598208B2/en not_active Expired - Fee Related
- 2008-08-14 SI SI200830269T patent/SI2195311T1/sl unknown
- 2008-08-14 ES ES08789611T patent/ES2361463T3/es active Active
- 2008-08-14 WO PCT/IB2008/053269 patent/WO2009024905A1/en active Application Filing
- 2008-08-14 DE DE602008005770T patent/DE602008005770D1/de active Active
- 2008-08-14 CA CA2695509A patent/CA2695509A1/en not_active Abandoned
- 2008-08-14 EP EP08789611A patent/EP2195311B1/en not_active Not-in-force
- 2008-08-14 PT PT08789611T patent/PT2195311E/pt unknown
- 2008-08-14 PL PL08789611T patent/PL2195311T3/pl unknown
- 2008-08-14 DK DK08789611.4T patent/DK2195311T3/da active
- 2008-08-14 CN CN200880103070.2A patent/CN102648198B/zh not_active Expired - Fee Related
- 2008-08-14 MX MX2010001881A patent/MX2010001881A/es active IP Right Grant
- 2008-08-14 KR KR1020107005759A patent/KR101541558B1/ko not_active IP Right Cessation
- 2008-08-14 AT AT08789611T patent/ATE502938T1/de active
- 2008-08-14 BR BRPI0815190 patent/BRPI0815190A2/pt not_active IP Right Cessation
- 2008-08-14 RU RU2010109542/04A patent/RU2492168C2/ru not_active IP Right Cessation
- 2008-08-14 JP JP2010520670A patent/JP5451614B2/ja not_active Expired - Fee Related
- 2008-08-14 MY MYPI2010000684A patent/MY153975A/en unknown
- 2008-08-15 TW TW097131346A patent/TWI422373B/zh not_active IP Right Cessation
- 2008-08-19 AR ARP080103611A patent/AR067977A1/es not_active Application Discontinuation
2010
- 2010-03-12 MA MA32693A patent/MA31703B1/fr unknown
- 2010-03-16 ZA ZA2010/01873A patent/ZA201001873B/en unknown
- 2010-12-03 HK HK10111281.3A patent/HK1144809A1/xx not_active IP Right Cessation
2011
- 2011-05-30 CY CY20111100521T patent/CY1111830T1/el unknown
- 2011-06-16 HR HR20110449T patent/HRP20110449T1/hr unknown

Also Published As

Publication number	Publication date
KR20100058561A (ko)	2010-06-03
CA2695509A1 (en)	2009-02-26
PT2195311E (pt)	2011-05-25
NZ583957A (en)	2011-09-30
AU2008290233B2 (en)	2013-10-10
TWI422373B (zh)	2014-01-11
AR067977A1 (es)	2009-10-28
HRP20110449T1 (hr)	2011-07-31
MX2010001881A (es)	2010-03-10
US8598208B2 (en)	2013-12-03
JP5451614B2 (ja)	2014-03-26
MY153975A (en)	2015-04-30
RU2492168C2 (ru)	2013-09-10
CY1111830T1 (el)	2015-10-07
ES2361463T3 (es)	2011-06-17
DK2195311T3 (da)	2011-05-23
JP2010536741A (ja)	2010-12-02
EP2195311A1 (en)	2010-06-16
HK1144809A1 (en)	2011-03-11
CN102648198B (zh)	2015-04-01
RU2010109542A (ru)	2011-09-27
KR101541558B1 (ko)	2015-08-03
US20110212998A1 (en)	2011-09-01
EP2195311B1 (en)	2011-03-23
PL2195311T3 (pl)	2011-08-31
ATE502938T1 (de)	2011-04-15
AU2008290233A1 (en)	2009-02-26
CN102648198A (zh)	2012-08-22
ZA201001873B (en)	2012-05-30
DE602008005770D1 (de)	2011-05-05
WO2009024905A1 (en)	2009-02-26
MA31703B1 (fr)	2010-09-01
TW200918055A (en)	2009-05-01
BRPI0815190A2 (pt)	2015-03-31

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