SI2078022T1 - Spiro benzazepini, uporabljeni kot antagonisti vazopresina - Google Patents

Spiro benzazepini, uporabljeni kot antagonisti vazopresina

Info

Publication number: SI2078022T1
Authority: SI; Slovenia
Prior art keywords: renal; hyponatremia; hypertension; insufficiency; formula
Prior art date: 2006-09-22

Application number

SI200730800T

Other languages

English (en)

Inventor

Min A Xiang

Mona Patel

Philip Rybczynski

Joseph Gunnet

Keith T Demarest

Richard Look

Bruce Maryanoff

Michael J Costanzo

Stephen C Yabut

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-22

Filing date

2007-09-19

Publication date

2012-01-31

2007-09-19 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2012-01-31 Publication of SI2078022T1 publication Critical patent/SI2078022T1/sl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

SI200730800T 2006-09-22 2007-09-19 Spiro benzazepini, uporabljeni kot antagonisti vazopresina SI2078022T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US82665406P	2006-09-22	2006-09-22
EP07842799A EP2078022B1 (en)	2006-09-22	2007-09-19	Spiro benzazepines used as vasopressin antagonists
PCT/US2007/078917 WO2008036755A1 (en)	2006-09-22	2007-09-19	Spiro benzazepines used as vasopressin antagonists

Publications (1)

Publication Number	Publication Date
SI2078022T1 true SI2078022T1 (sl)	2012-01-31

Family

ID=39030853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200730800T SI2078022T1 (sl)	2006-09-22	2007-09-19	Spiro benzazepini, uporabljeni kot antagonisti vazopresina

Country Status (14)

Country	Link
US (1)	US7825110B2 (sl)
EP (1)	EP2078022B1 (sl)
JP (1)	JP2010504351A (sl)
CN (1)	CN101541806A (sl)
AT (1)	ATE532786T1 (sl)
AU (1)	AU2007299818B2 (sl)
CA (1)	CA2665849A1 (sl)
CY (1)	CY1112270T1 (sl)
DK (1)	DK2078022T3 (sl)
ES (1)	ES2374582T3 (sl)
PL (1)	PL2078022T3 (sl)
PT (1)	PT2078022E (sl)
SI (1)	SI2078022T1 (sl)
WO (1)	WO2008036755A1 (sl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2781521A4 (en) *	2011-10-19	2015-03-04	Kowa Co	NOVEL COMPOUND OF SPIROINDOLINE AND THERAPEUTIC AGENT CONTAINING THE SAME
US10214520B2 (en)	2014-07-15	2019-02-26	Gruenenthal Gmbh	Substituted azaspiro(4.5)decane derivatives
TW201607923A (zh)	2014-07-15	2016-03-01	歌林達有限公司	被取代之氮螺環（４．５）癸烷衍生物
EP3321271A4 (en)	2015-07-07	2020-12-16	Japan Tobacco Inc.	PROCESS FOR THE PREPARATION OF 7H-PYRROLO [2,3-D] PYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF
WO2018117152A1 (ja) *	2016-12-21	2018-06-28	日本たばこ産業株式会社	７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその合成中間体
CN111295373A (zh) *	2017-09-15	2020-06-16	阿泽凡药物公司	用于治疗脑损伤的组合物和方法
US20200337590A1 (en)	2018-01-16	2020-10-29	Bayer Aktiengesellschaft	Assistance in the treatment of cardiac insufficiency
US20240101568A1 (en) *	2020-11-26	2024-03-28	Shanghai Jemincare Pharmaceutical Co., Ltd	Novel benzazepine spiro derivative
CN112939864B (zh) *	2021-01-29	2022-05-06	中国医科大学	螺[苯并[c]氮杂-1,1’-环己基]-3-酮类化合物

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4617302A (en)	1984-10-15	1986-10-14	Eli Lilly And Company	Inotropic agents
US5985869A (en)	1989-10-20	1999-11-16	Otsuka Pharmaceutical Company, Limited	Benzoheterocyclic compounds
US5258510A (en)	1989-10-20	1993-11-02	Otsuka Pharma Co Ltd	Benzoheterocyclic compounds
JP2905909B2 (ja) *	1991-04-19	1999-06-14	大塚製薬株式会社	バソプレシン拮抗剤
ES2089033T3 (es)	1989-10-20	1996-10-01	Otsuka Pharma Co Ltd	Compuestos benzoheterociclicos.
FR2686878B1 (fr) *	1992-01-30	1995-06-30	Sanofi Elf	Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant.
US5686624A (en)	1992-01-30	1997-11-11	Sanofi	1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5663431A (en)	1992-01-30	1997-09-02	Sanofi	1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708605A1 (fr) *	1993-07-30	1995-02-10	Sanofi Sa	Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
US5849780A (en)	1992-01-30	1998-12-15	Sanofi	1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
AU5292393A (en)	1992-10-07	1994-04-26	Merck & Co., Inc.	Tocolytic oxytocin receptor antagonists
US5512563A (en)	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
FR2708606B1 (fr) *	1993-07-30	1995-10-27	Sanofi Sa	Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
US5464788A (en)	1994-03-24	1995-11-07	Merck & Co., Inc.	Tocolytic oxytocin receptor antagonists
US5753648A (en)	1995-01-17	1998-05-19	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
AUPP150098A0 (en)	1998-01-27	1998-02-19	Fujisawa Pharmaceutical Co., Ltd.	Benzamide derivatives
NZ523450A (en)	2000-07-05	2004-11-26	Ortho Mcneil Pharm Inc	Nonpeptide substituted spirobenzoazepines as vasopressin receptor antagonists
CA2432825A1 (en) *	2000-12-15	2002-06-20	Emory University	Nonpeptide agonists and antagonists of vasopressin receptors
US7011898B2 (en) *	2003-03-21	2006-03-14	Air Products And Chemicals, Inc.	Method of joining ITM materials using a partially or fully-transient liquid phase
BRPI0411598A (pt)	2003-06-17	2006-08-29	Janssen Pharmaceutica Nv	espirobenzazepinas substituìdas
AU2004252135A1 (en)	2003-06-17	2005-01-06	Janssen Pharmaceutica N.V.	Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives
CA2637838A1 (en)	2006-01-20	2007-07-26	Janssen Pharmaceutica N.V.	Novel solid forms of (4r)-1-¬4-(2-chloro-5-fluorobenzoyl)amino-3-methoxybenzoyl\|-1,2,3,5-tetrahydro-spiro¬4h-1-benzazepine-4,1'-¬2\|cyclopentene\|-3'-carboxylic acid

2007
- 2007-09-19 PT PT07842799T patent/PT2078022E/pt unknown
- 2007-09-19 DK DK07842799.4T patent/DK2078022T3/da active
- 2007-09-19 AT AT07842799T patent/ATE532786T1/de active
- 2007-09-19 PL PL07842799T patent/PL2078022T3/pl unknown
- 2007-09-19 US US11/857,891 patent/US7825110B2/en not_active Expired - Fee Related
- 2007-09-19 JP JP2009529369A patent/JP2010504351A/ja active Pending
- 2007-09-19 CA CA002665849A patent/CA2665849A1/en not_active Abandoned
- 2007-09-19 WO PCT/US2007/078917 patent/WO2008036755A1/en active Application Filing
- 2007-09-19 ES ES07842799T patent/ES2374582T3/es active Active
- 2007-09-19 CN CNA2007800432003A patent/CN101541806A/zh active Pending
- 2007-09-19 SI SI200730800T patent/SI2078022T1/sl unknown
- 2007-09-19 AU AU2007299818A patent/AU2007299818B2/en not_active Expired - Fee Related
- 2007-09-19 EP EP07842799A patent/EP2078022B1/en active Active
2012
- 2012-01-24 CY CY20121100081T patent/CY1112270T1/el unknown

Also Published As

Publication number	Publication date
PL2078022T3 (pl)	2012-04-30
CN101541806A (zh)	2009-09-23
CY1112270T1 (el)	2015-12-09
AU2007299818B2 (en)	2012-08-02
EP2078022B1 (en)	2011-11-09
ATE532786T1 (de)	2011-11-15
PT2078022E (pt)	2012-01-11
WO2008036755A1 (en)	2008-03-27
JP2010504351A (ja)	2010-02-12
EP2078022A1 (en)	2009-07-15
CA2665849A1 (en)	2008-03-27
DK2078022T3 (da)	2012-02-13
US7825110B2 (en)	2010-11-02
AU2007299818A1 (en)	2008-03-27
ES2374582T3 (es)	2012-02-20
US20080076753A1 (en)	2008-03-27

Publication	Publication Date	Title
PL2078022T3 (pl)	2012-04-30	Spirobenzoazepiny stosowane jako antagoniści wazopresyny
MY128065A (en)	2007-01-31	Tricyclic benzodiazepines as vasopressin receptor antagonists
MA33358B1 (fr)	2012-06-01	Arylpyridine en tant qu'inhibiteurs de l'aldostérone synthase
CR8168A (es)	2008-09-10	Espirobenzazepinas sustituidas
WO2009089537A3 (en)	2009-11-19	Anti-cancer compounds
MX2012012902A (es)	2012-12-17	Analogos heteroarilo biciclicos como moduladores de receptor acoplado a la proteina g gpr119.
MY147789A (en)	2013-01-31	Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
TWI316057B (en)	2009-10-21	Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
MX352548B (es)	2017-11-29	Compuestos disustituidos de tetrahidrofuranilo como antagonistas de receptor de bradiquinina b1.
MX2013004739A (es)	2013-07-02	Derivados heterociclicos de diazenodiolato.
WO2006049984A3 (en)	2006-10-19	Novel [1,4]benzodiazepines as vasopressin v2 receptor antagonists
ATE282621T1 (de)	2004-12-15	Indoloazepine als vasopressin rezeptor antagonisten
PE20140606A1 (es)	2014-05-17	Derivados de pirazol utiles como inhibidores de aldosterona sintasa
YU32702A (sh)	2005-06-10	Nepeptidni supstituisani benzotiazepini kao antagonisti vazopresina
WO2007074130A3 (de)	2007-08-16	3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1h)-on
MA34462B1 (fr)	2013-08-01	Composes de thiophene 2,3,5- trisubstitues et leurs utilisations
PE20071234A1 (es)	2008-01-14	Composiciones a base de bh4 para el tratamiento de la enfermedad vascular
JP2012526773A5 (sl)	2013-06-06
TN2013000050A1 (en)	2014-06-25	Disubstituted tetrahydrofuranyl compounds as antagonists of the bradykinin b1 receptor